Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
11272103 124375 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
CHEMBL363840 124375 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
11272103 124375 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.087
CHEMBL363840 124375 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.087
11272103 124375 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil at 30 nMAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil at 30 nM
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.087
CHEMBL363840 124375 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil at 30 nMAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil at 30 nM
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.087
11272103 124375 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL363840 124375 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
11272103 124375 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL363840 124375 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
44455820 95442 0 None - 1 Human 11.0 pIC50 = 11.0 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 551 11 3 7 4.9 CCC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL257074 95442 0 None - 1 Human 11.0 pIC50 = 11.0 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 551 11 3 7 4.9 CCC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 10.1016/j.bmcl.2007.11.067
10458976 95011 0 None - 1 Human 10.9 pIC50 = 10.9 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 509 9 3 7 3.4 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254930 95011 0 None - 1 Human 10.9 pIC50 = 10.9 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 509 9 3 7 3.4 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44455711 168733 0 None - 1 Human 10.9 pIC50 = 10.9 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 509 9 3 7 3.8 CCc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL437031 168733 0 None - 1 Human 10.9 pIC50 = 10.9 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 509 9 3 7 3.8 CCc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11340670 127234 0 None - 1 Human 10.8 pIC50 = 10.8 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 483 7 2 3 5.8 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F 10.1021/jm049530m
CHEMBL365820 127234 0 None - 1 Human 10.8 pIC50 = 10.8 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 483 7 2 3 5.8 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F 10.1021/jm049530m
11328714 78998 0 None - 1 Human 10.8 pIC50 = 10.8 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113074 78998 0 None - 1 Human 10.8 pIC50 = 10.8 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44455686 95492 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 523 9 3 7 4.3 CC(C)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL257293 95492 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 523 9 3 7 4.3 CC(C)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455869 97545 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 507 9 2 7 4.1 CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL270582 97545 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 507 9 2 7 4.1 CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455509 166426 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 493 9 2 6 4.4 CCc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL427728 166426 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 493 9 2 6 4.4 CCc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455485 155498 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 507 9 2 6 5.0 CC(C)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL404122 155498 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 507 9 2 6 5.0 CC(C)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11329244 71116 11 None 20 7 Human 10.5 pIC50 = 10.5 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL195433 71116 11 None 20 7 Human 10.5 pIC50 = 10.5 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
11329244 71116 11 None 20 7 Human 10.5 pIC50 = 10.5 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
CHEMBL195433 71116 11 None 20 7 Human 10.5 pIC50 = 10.5 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
11227406 94345 2 None 107 4 Human 10.5 pIC50 = 10.5 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
CHEMBL250689 94345 2 None 107 4 Human 10.5 pIC50 = 10.5 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
11227406 94345 2 None 107 4 Human 10.5 pIC50 = 10.5 Functional
Antagonist activity at CCR3 assessed as inhibition of chemotaxis by cell based assayAntagonist activity at CCR3 assessed as inhibition of chemotaxis by cell based assay
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm300682j
CHEMBL250689 94345 2 None 107 4 Human 10.5 pIC50 = 10.5 Functional
Antagonist activity at CCR3 assessed as inhibition of chemotaxis by cell based assayAntagonist activity at CCR3 assessed as inhibition of chemotaxis by cell based assay
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm300682j
11227406 94345 2 None 107 4 Human 10.5 pIC50 = 10.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL250689 94345 2 None 107 4 Human 10.5 pIC50 = 10.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
11227406 94345 2 None 107 4 Human 10.5 pIC50 = 10.5 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL250689 94345 2 None 107 4 Human 10.5 pIC50 = 10.5 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
10050884 154652 14 None -1 3 Human 10.4 pIC50 = 10.4 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.087
CHEMBL399495 154652 14 None -1 3 Human 10.4 pIC50 = 10.4 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.087
11227406 94345 2 None 107 4 Human 10.4 pIC50 = 10.4 Functional
Inhibition of eotaxin-induced chemotaxis of Cynomolgus monkey eosinophilsInhibition of eotaxin-induced chemotaxis of Cynomolgus monkey eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL250689 94345 2 None 107 4 Human 10.4 pIC50 = 10.4 Functional
Inhibition of eotaxin-induced chemotaxis of Cynomolgus monkey eosinophilsInhibition of eotaxin-induced chemotaxis of Cynomolgus monkey eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
10050884 154652 14 None -1 3 Human 10.4 pIC50 = 10.4 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
CHEMBL399495 154652 14 None -1 3 Human 10.4 pIC50 = 10.4 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
11169258 140897 0 None - 1 Human 10.4 pIC50 = 10.4 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 587 8 2 10 3.8 Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1021/jm049530m
CHEMBL382108 140897 0 None - 1 Human 10.4 pIC50 = 10.4 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 587 8 2 10 3.8 Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1021/jm049530m
11488078 79001 0 None - 1 Human 10.4 pIC50 = 10.4 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113077 79001 0 None - 1 Human 10.4 pIC50 = 10.4 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44455683 155088 0 None - 1 Human 10.3 pIC50 = 10.3 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 531 9 3 7 4.4 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL401879 155088 0 None - 1 Human 10.3 pIC50 = 10.3 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 531 9 3 7 4.4 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
44455745 155301 0 None - 1 Human 10.3 pIC50 = 10.3 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 559 8 3 7 4.0 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(Br)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL402983 155301 0 None - 1 Human 10.3 pIC50 = 10.3 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 559 8 3 7 4.0 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(Br)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455793 95227 0 None - 1 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 483 9 3 5 4.4 CC(=O)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL256068 95227 0 None - 1 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 483 9 3 5 4.4 CC(=O)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
11397114 133469 0 None - 1 Human 10.2 pIC50 = 10.2 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2cn[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL3706810 133469 0 None - 1 Human 10.2 pIC50 = 10.2 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2cn[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44455766 95685 0 None - 1 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 479 8 2 6 4.3 C[C@H](C[C@@H](C)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL258156 95685 0 None - 1 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 479 8 2 6 4.3 C[C@H](C[C@@H](C)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11953409 94216 0 None 7 4 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249854 94216 0 None 7 4 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445847 94424 0 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 487 7 3 6 3.8 CC(=O)c1sc(NC(=O)N[C@@H]2CNCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251079 94424 0 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 487 7 3 6 3.8 CC(=O)c1sc(NC(=O)N[C@@H]2CNCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
11214474 71353 0 None - 1 Human 10.1 pIC50 = 10.1 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 514 6 2 4 6.7 O=C(Nc1nc2c(Cl)cccc2s1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL195790 71353 0 None - 1 Human 10.1 pIC50 = 10.1 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 514 6 2 4 6.7 O=C(Nc1nc2c(Cl)cccc2s1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44445845 94242 0 None - 1 Human 10.0 pIC50 = 10 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 487 7 3 6 3.8 CC(=O)c1sc(NC(=O)N[C@@H]2CCNC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL250056 94242 0 None - 1 Human 10.0 pIC50 = 10 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 487 7 3 6 3.8 CC(=O)c1sc(NC(=O)N[C@@H]2CCNC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455845 97459 0 None - 1 Human 10.0 pIC50 = 10 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 537 10 3 7 4.5 CC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL270146 97459 0 None - 1 Human 10.0 pIC50 = 10 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 537 10 3 7 4.5 CC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 10.1016/j.bmcl.2007.11.067
44455846 97460 0 None - 1 Human 10.0 pIC50 = 10 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 515 9 2 6 5.1 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL270147 97460 0 None - 1 Human 10.0 pIC50 = 10 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 515 9 2 6 5.1 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
44455458 167457 0 None - 1 Human 10.0 pIC50 = 10 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 533 9 3 7 5.3 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2ccon2)cc(-c2ccon2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL429846 167457 0 None - 1 Human 10.0 pIC50 = 10 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 533 9 3 7 5.3 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2ccon2)cc(-c2ccon2)c1 10.1016/j.bmcl.2007.11.067
11454941 71142 0 None - 1 Human 10.0 pIC50 = 10 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 505 7 2 6 4.7 Cc1nnnn1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL195555 71142 0 None - 1 Human 10.0 pIC50 = 10 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 505 7 2 6 4.7 Cc1nnnn1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
10050884 154652 14 None 1 3 Crab-eating macaque 9.8 pIC50 = 9.8 Functional
Antagonist activity at CCR3 receptor in cynomolgus monkey eosinophil assessed as as inhibition of chemotaxisAntagonist activity at CCR3 receptor in cynomolgus monkey eosinophil assessed as as inhibition of chemotaxis
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
CHEMBL399495 154652 14 None 1 3 Crab-eating macaque 9.8 pIC50 = 9.8 Functional
Antagonist activity at CCR3 receptor in cynomolgus monkey eosinophil assessed as as inhibition of chemotaxisAntagonist activity at CCR3 receptor in cynomolgus monkey eosinophil assessed as as inhibition of chemotaxis
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
44455459 95091 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 467 9 2 4 5.1 CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL255398 95091 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 467 9 2 4 5.1 CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
10140602 166618 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 479 7 2 6 3.4 C[C@H](CC(=O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL428071 166618 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 479 7 2 6 3.4 C[C@H](CC(=O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11398022 98631 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 10.1021/jm049530m
CHEMBL277131 98631 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 10.1021/jm049530m
44455484 167406 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 493 9 2 6 4.6 CC(C)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL429604 167406 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 493 9 2 6 4.6 CC(C)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455483 97829 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 537 10 3 7 3.8 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)(C)C(=O)O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL272068 97829 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 537 10 3 7 3.8 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)(C)C(=O)O)c1 10.1016/j.bmcl.2007.11.067
11385766 132796 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL370082 132796 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
11236950 94764 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 479 9 2 6 4.3 CN(CCCc1ccc(F)cc1)C[C@@H]1CCCC[C@H]1NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL253210 94764 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 479 9 2 6 4.3 CN(CCCc1ccc(F)cc1)C[C@@H]1CCCC[C@H]1NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
71460523 81494 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at CCR3 receptor in human eosinophils assessed as inhibition of CCL11-induced degranulation after 4 hrs by ELISAAntagonist activity at CCR3 receptor in human eosinophils assessed as inhibition of CCL11-induced degranulation after 4 hrs by ELISA
ChEMBL 423 7 3 4 3.7 O=C(Nc1ccccc1OCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160099 81494 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at CCR3 receptor in human eosinophils assessed as inhibition of CCL11-induced degranulation after 4 hrs by ELISAAntagonist activity at CCR3 receptor in human eosinophils assessed as inhibition of CCL11-induced degranulation after 4 hrs by ELISA
ChEMBL 423 7 3 4 3.7 O=C(Nc1ccccc1OCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
44455817 155178 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 538 9 3 8 3.6 CNC(=O)O[C@H](C[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)N1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
CHEMBL402331 155178 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 538 9 3 8 3.6 CNC(=O)O[C@H](C[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)N1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
10050884 154652 14 None -1 3 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-stimulated intracellular calcium fluxAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-stimulated intracellular calcium flux
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
CHEMBL399495 154652 14 None -1 3 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-stimulated intracellular calcium fluxAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-stimulated intracellular calcium flux
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
44445854 94083 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 522 7 2 7 3.3 CC(=O)c1sc(NC(=O)N[C@@H]2CS(=O)(=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249057 94083 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 522 7 2 7 3.3 CC(=O)c1sc(NC(=O)N[C@@H]2CS(=O)(=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
45267588 196034 0 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 501 5 2 4 4.5 Cc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c(O)c1 10.1016/j.bmc.2009.06.066
CHEMBL560275 196034 0 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 501 5 2 4 4.5 Cc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c(O)c1 10.1016/j.bmc.2009.06.066
44512617 195338 0 None 79 2 Human 9.0 pIC50 = 9 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells by functional inhibition curve analysisAntagonist activity at human CCR3 expressed in mouse B300-19 cells by functional inhibition curve analysis
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL551735 195338 0 None 79 2 Human 9.0 pIC50 = 9 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells by functional inhibition curve analysisAntagonist activity at human CCR3 expressed in mouse B300-19 cells by functional inhibition curve analysis
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
44455658 167273 0 None - 1 Human 9.0 pIC50 = 9 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 479 8 3 5 4.4 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nccn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL429323 167273 0 None - 1 Human 9.0 pIC50 = 9 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 479 8 3 5 4.4 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nccn2C)c1 10.1016/j.bmcl.2007.11.067
44289715 170235 0 None - 1 Human 9.0 pIC50 = 9 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 465 8 2 6 3.8 Cc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL444568 170235 0 None - 1 Human 9.0 pIC50 = 9 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 465 8 2 6 3.8 Cc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11272103 124375 0 None -37 8 Human 9.0 pIC50 = 9 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL363840 124375 0 None -37 8 Human 9.0 pIC50 = 9 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
11363006 70435 0 None - 1 Human 9.0 pIC50 = 9 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 453 7 2 3 5.5 COc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 10.1021/jm049530m
CHEMBL194601 70435 0 None - 1 Human 9.0 pIC50 = 9 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 453 7 2 3 5.5 COc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 10.1021/jm049530m
44455539 166982 0 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 465 8 2 6 3.9 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL428775 166982 0 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 465 8 2 6 3.9 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
45271892 195340 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 515 5 1 5 4.3 O=C(C=C1CCN(C(=O)c2ccc3c(c2)OCO3)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL551739 195340 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 515 5 1 5 4.3 O=C(C=C1CCN(C(=O)c2ccc3c(c2)OCO3)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
71460523 81494 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 423 7 3 4 3.7 O=C(Nc1ccccc1OCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160099 81494 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 423 7 3 4 3.7 O=C(Nc1ccccc1OCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
45271891 195339 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 501 6 1 4 4.5 COc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)cc1 10.1016/j.bmc.2009.06.066
CHEMBL551738 195339 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 501 6 1 4 4.5 COc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)cc1 10.1016/j.bmc.2009.06.066
11363005 60506 0 None - 1 Human 8.0 pIC50 = 8 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 453 7 2 3 5.5 COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL175634 60506 0 None - 1 Human 8.0 pIC50 = 8 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 453 7 2 3 5.5 COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11329244 71116 11 None -20 7 Mouse 8.0 pIC50 = 8 Functional
Inhibition of eotaxin-induced chemotaxis of mouse eosinophilsInhibition of eotaxin-induced chemotaxis of mouse eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
CHEMBL195433 71116 11 None -20 7 Mouse 8.0 pIC50 = 8 Functional
Inhibition of eotaxin-induced chemotaxis of mouse eosinophilsInhibition of eotaxin-induced chemotaxis of mouse eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
45269392 196026 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 374 5 1 2 4.4 O=C(/C=C/c1ccccc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL560198 196026 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 374 5 1 2 4.4 O=C(/C=C/c1ccccc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
71449694 81498 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 437 8 3 4 3.9 O=C(Nc1ccccc1COCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160102 81498 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 437 8 3 4 3.9 O=C(Nc1ccccc1COCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
70694703 76147 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 578 5 2 3 6.1 O=C(Nc1cccc(Br)c1)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
CHEMBL2057764 76147 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 578 5 2 3 6.1 O=C(Nc1cccc(Br)c1)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
44451981 161271 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 454 6 1 3 6.2 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1cccc(Oc2ccccc2)c1 10.1016/j.bmc.2007.10.003
CHEMBL412061 161271 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 454 6 1 3 6.2 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1cccc(Oc2ccccc2)c1 10.1016/j.bmc.2007.10.003
44282031 119815 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 488 8 2 5 3.2 CC(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)N1CCCC1 10.1016/s0960-894x(01)00249-9
CHEMBL34839 119815 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 488 8 2 5 3.2 CC(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)N1CCCC1 10.1016/s0960-894x(01)00249-9
11363005 60506 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 453 7 2 3 5.5 COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL175634 60506 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 453 7 2 3 5.5 COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44281673 110356 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 572 10 3 5 5.6 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N[C@H](C(=O)Nc1ccccc1)c1ccccc1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL32410 110356 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 572 10 3 5 5.6 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N[C@H](C(=O)Nc1ccccc1)c1ccccc1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
76331527 103363 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 486 6 1 3 6.6 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1OC1CCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084575 103363 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 486 6 1 3 6.6 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1OC1CCCCC1 10.1016/j.bmc.2008.08.006
71458677 81470 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 423 7 3 4 3.7 O=C(Nc1ccc(OCCO)cc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2159868 81470 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 423 7 3 4 3.7 O=C(Nc1ccc(OCCO)cc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
76316939 103367 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 513 5 1 3 5.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084579 103367 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 513 5 1 3 5.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCCCCC1 10.1016/j.bmc.2008.08.006
45270978 196514 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 489 5 1 3 4.7 O=C(C=C1CCN(C(=O)c2cccc(F)c2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL563536 196514 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 489 5 1 3 4.7 O=C(C=C1CCN(C(=O)c2cccc(F)c2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
44282048 111636 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 520 9 3 5 4.2 COc1ccccc1NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(C#N)cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL32852 111636 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 520 9 3 5 4.2 COc1ccccc1NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(C#N)cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
44282385 100083 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 562 7 1 6 6.1 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1nc(C(=O)N2CCc3ccccc3C2)cs1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL287320 100083 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 562 7 1 6 6.1 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1nc(C(=O)N2CCc3ccccc3C2)cs1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
76327878 103359 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 500 5 1 4 4.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccncc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084571 103359 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 500 5 1 4 4.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccncc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
70686358 76146 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 578 5 2 3 6.1 O=C(Nc1ccccc1Br)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
CHEMBL2057763 76146 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 578 5 2 3 6.1 O=C(Nc1ccccc1Br)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
70682102 76149 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 518 5 2 3 5.4 O=C(Nc1ccccc1F)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
CHEMBL2057766 76149 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 518 5 2 3 5.4 O=C(Nc1ccccc1F)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
2729098 80495 2 None -11 2 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 362 4 1 2 4.4 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1 10.1016/j.bmc.2007.10.003
CHEMBL214726 80495 2 None -11 2 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 362 4 1 2 4.4 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1 10.1016/j.bmc.2007.10.003
76309741 103368 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 500 5 1 4 4.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ncccc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084580 103368 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 500 5 1 4 4.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ncccc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
44399469 166126 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibitory concentration against BaF3 cell line expressed recombinant human CCR3 using the LDH assayInhibitory concentration against BaF3 cell line expressed recombinant human CCR3 using the LDH assay
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL426089 166126 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibitory concentration against BaF3 cell line expressed recombinant human CCR3 using the LDH assayInhibitory concentration against BaF3 cell line expressed recombinant human CCR3 using the LDH assay
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
71449677 81465 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 448 5 2 4 2.3 CS(=O)(=O)N1CCC(NC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 10.1016/j.bmcl.2012.09.035
CHEMBL2159863 81465 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 448 5 2 4 2.3 CS(=O)(=O)N1CCC(NC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 10.1016/j.bmcl.2012.09.035
45271843 196370 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 517 6 2 5 4.2 COc1ccc(O)c(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c1 10.1016/j.bmc.2009.06.066
CHEMBL562574 196370 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 517 6 2 5 4.2 COc1ccc(O)c(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c1 10.1016/j.bmc.2009.06.066
45267629 196350 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 424 5 1 2 5.7 O=C(N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
CHEMBL562475 196350 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 424 5 1 2 5.7 O=C(N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
23509697 194950 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assay
ChEMBL 440 6 2 4 3.6 COc1cccc(NC(=O)N2CCNC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL54273 194950 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assay
ChEMBL 440 6 2 4 3.6 COc1cccc(NC(=O)N2CCNC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
44282006 123647 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 525 10 3 5 4.3 COc1ccc(C[C@H](NC(=O)c2cccc3ccccc23)C(=O)N[C@@H](C)C(=O)Nc2ccccc2OC)cc1 10.1016/s0960-894x(01)00249-9
CHEMBL36195 123647 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 525 10 3 5 4.3 COc1ccc(C[C@H](NC(=O)c2cccc3ccccc23)C(=O)N[C@@H](C)C(=O)Nc2ccccc2OC)cc1 10.1016/s0960-894x(01)00249-9
44440402 93917 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of calcium fluxAntagonist activity at human CCR3 receptor assessed as inhibition of calcium flux
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL248179 93917 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of calcium fluxAntagonist activity at human CCR3 receptor assessed as inhibition of calcium flux
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
44440402 93917 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of eotaxin-induced eosinophil shape changeAntagonist activity at human CCR3 receptor assessed as inhibition of eotaxin-induced eosinophil shape change
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL248179 93917 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of eotaxin-induced eosinophil shape changeAntagonist activity at human CCR3 receptor assessed as inhibition of eotaxin-induced eosinophil shape change
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
45270977 195151 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 409 4 1 3 3.2 CC(=O)N1CCC(=CC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 10.1016/j.bmc.2009.06.066
CHEMBL550255 195151 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 409 4 1 3 3.2 CC(=O)N1CCC(=CC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 10.1016/j.bmc.2009.06.066
70682100 76140 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 568 4 1 3 5.9 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCN(C(=O)c2c(Cl)cccc2Cl)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057757 76140 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 568 4 1 3 5.9 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCN(C(=O)c2c(Cl)cccc2Cl)CC1 10.1016/j.bmcl.2012.06.042
11430170 123833 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 423 6 2 2 5.5 O=C(Nc1ccccc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL362466 123833 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 423 6 2 2 5.5 O=C(Nc1ccccc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
45271911 195057 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 362 5 1 2 3.9 O=C(Cc1ccccc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL549514 195057 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 362 5 1 2 3.9 O=C(Cc1ccccc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
44452250 96234 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 362 4 1 2 4.8 O=C(Nc1ccccc1)C1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
CHEMBL260900 96234 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 362 4 1 2 4.8 O=C(Nc1ccccc1)C1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
44281793 100114 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 414 7 1 5 4.7 CCn1ccnc1[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL287538 100114 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 414 7 1 5 4.7 CCn1ccnc1[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
70688459 76139 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 568 5 1 3 6.7 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(Cc2c(Cl)cccc2Cl)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057756 76139 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 568 5 1 3 6.7 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(Cc2c(Cl)cccc2Cl)CC1 10.1016/j.bmcl.2012.06.042
44281891 125708 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 474 8 2 6 4.7 CCNC(=O)c1csc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 10.1016/s0960-894x(01)00249-9
CHEMBL36473 125708 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 474 8 2 6 4.7 CCNC(=O)c1csc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 10.1016/s0960-894x(01)00249-9
44281612 109625 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 510 9 3 5 4.2 C[C@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccccc1 10.1016/s0960-894x(01)00249-9
CHEMBL32224 109625 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 510 9 3 5 4.2 C[C@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccccc1 10.1016/s0960-894x(01)00249-9
10194663 81500 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 423 7 3 4 3.7 O=C(Nc1cccc(OCCO)c1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160104 81500 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 423 7 3 4 3.7 O=C(Nc1cccc(OCCO)c1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
70692659 76085 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 499 7 1 3 5.5 O=C(NCCCN1CCC(C(c2ccccc2)c2ccccc2)CC1)N1CCc2cc(F)ccc2C1=O 10.1016/j.bmcl.2012.06.042
CHEMBL2057490 76085 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 499 7 1 3 5.5 O=C(NCCCN1CCC(C(c2ccccc2)c2ccccc2)CC1)N1CCc2cc(F)ccc2C1=O 10.1016/j.bmcl.2012.06.042
11409583 69782 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 507 8 2 4 5.9 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1021/jm049530m
CHEMBL193575 69782 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 507 8 2 4 5.9 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1021/jm049530m
11454941 71142 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 505 7 2 6 4.7 Cc1nnnn1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL195555 71142 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 505 7 2 6 4.7 Cc1nnnn1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
11328714 78998 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113074 78998 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11488078 79001 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113077 79001 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11169258 140897 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 587 8 2 10 3.8 Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1021/jm049530m
CHEMBL382108 140897 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 587 8 2 10 3.8 Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1021/jm049530m
44401328 71096 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL195348 71096 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 10.1021/jm049530m
71460525 81507 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 526 6 3 5 3.4 O=C(NC1CCN(S(=O)(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160111 81507 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 526 6 3 5 3.4 O=C(NC1CCN(S(=O)(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
44290039 178802 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL46905 178802 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
11953409 94216 0 None 7 4 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at CCR3 in human eosinophils assessed as eotaxin-induced calcium mobilization by FLIPR assayAntagonist activity at CCR3 in human eosinophils assessed as eotaxin-induced calcium mobilization by FLIPR assay
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249854 94216 0 None 7 4 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at CCR3 in human eosinophils assessed as eotaxin-induced calcium mobilization by FLIPR assayAntagonist activity at CCR3 in human eosinophils assessed as eotaxin-induced calcium mobilization by FLIPR assay
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44447144 168772 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 483 11 3 7 3.0 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL437396 168772 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 483 11 3 7 3.0 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
10474776 113657 42 None - 1 Human 7.7 pIC50 = 7.7 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand, using [Ca2+] mobilization assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand, using [Ca2+] mobilization assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL33227 113657 42 None - 1 Human 7.7 pIC50 = 7.7 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand, using [Ca2+] mobilization assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand, using [Ca2+] mobilization assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
44281975 99629 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 491 8 2 6 3.9 C[C@@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)OC(C)(C)C 10.1016/s0960-894x(01)00249-9
CHEMBL284166 99629 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 491 8 2 6 3.9 C[C@@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)OC(C)(C)C 10.1016/s0960-894x(01)00249-9
44452168 95851 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 464 5 1 2 6.6 O=C(NC1C[C@@H]2CC[C@@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2007.10.003
CHEMBL258996 95851 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 464 5 1 2 6.6 O=C(NC1C[C@@H]2CC[C@@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2007.10.003
24882359 193047 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 464 5 1 2 6.6 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2008.08.006
CHEMBL522295 193047 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 464 5 1 2 6.6 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2008.08.006
70696744 76086 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 464 5 1 2 6.6 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2012.06.042
CHEMBL2057491 76086 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 464 5 1 2 6.6 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2012.06.042
24882359 193047 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 464 5 1 2 6.6 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
CHEMBL522295 193047 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 464 5 1 2 6.6 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
3492 692 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
In vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assay
ChEMBL 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 10.1016/s0960-894x(02)00206-8
9868459 692 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
In vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assay
ChEMBL 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 10.1016/s0960-894x(02)00206-8
CHEMBL50593 692 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
In vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assay
ChEMBL 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 10.1016/s0960-894x(02)00206-8
11272103 124375 0 None -1995 8 Mouse 7.7 pIC50 = 7.7 Functional
Inhibition of eotaxin-induced chemotaxis of mouse eosinophilsInhibition of eotaxin-induced chemotaxis of mouse eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL363840 124375 0 None -1995 8 Mouse 7.7 pIC50 = 7.7 Functional
Inhibition of eotaxin-induced chemotaxis of mouse eosinophilsInhibition of eotaxin-induced chemotaxis of mouse eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
22393339 186736 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assay
ChEMBL 410 7 2 3 4.7 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(Cl)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL48873 186736 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assay
ChEMBL 410 7 2 3 4.7 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(Cl)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
23509693 191493 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assay
ChEMBL 540 6 1 5 5.2 COc1cccc(NC(=O)N2CCN(C(=O)OC(C)(C)C)C(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL51937 191493 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assay
ChEMBL 540 6 1 5 5.2 COc1cccc(NC(=O)N2CCN(C(=O)OC(C)(C)C)C(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
71462227 81504 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 466 4 0 3 6.6 O=C1OC2(CCN(Cc3ccc4cc(F)ccc4c3)CC2)c2ccccc2N1Cc1ccccc1 10.1016/j.bmcl.2012.09.035
CHEMBL2160108 81504 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 466 4 0 3 6.6 O=C1OC2(CCN(Cc3ccc4cc(F)ccc4c3)CC2)c2ccccc2N1Cc1ccccc1 10.1016/j.bmcl.2012.09.035
45270135 195267 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 441 5 2 4 3.6 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)NS(=O)(=O)c1ccccc1 10.1016/j.bmc.2009.06.066
CHEMBL551205 195267 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 441 5 2 4 3.6 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)NS(=O)(=O)c1ccccc1 10.1016/j.bmc.2009.06.066
45268444 196018 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 458 6 1 3 5.6 O=C(C=C1CCC(Oc2ccccc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL560135 196018 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 458 6 1 3 5.6 O=C(C=C1CCC(Oc2ccccc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
44282030 111632 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 461 8 1 7 3.5 CCOC(=O)C1COC([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)=N1 10.1016/s0960-894x(01)00249-9
CHEMBL32850 111632 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 461 8 1 7 3.5 CCOC(=O)C1COC([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)=N1 10.1016/s0960-894x(01)00249-9
76320670 103362 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 454 5 1 4 5.1 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-n1ccnc1 10.1016/j.bmc.2008.08.006
CHEMBL3084574 103362 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 454 5 1 4 5.1 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-n1ccnc1 10.1016/j.bmc.2008.08.006
45270980 195176 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 489 5 1 3 4.7 O=C(C=C1CCN(C(=O)c2ccc(F)cc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL550464 195176 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 489 5 1 3 4.7 O=C(C=C1CCN(C(=O)c2ccc(F)cc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
44447361 94953 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 453 9 4 8 1.8 C[C@@H]([C@@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254503 94953 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 453 9 4 8 1.8 C[C@@H]([C@@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
23509695 189739 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assay
ChEMBL 441 6 1 4 4.0 COc1cccc(NC(=O)N2CCOC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL51584 189739 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assay
ChEMBL 441 6 1 4 4.0 COc1cccc(NC(=O)N2CCOC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
76331526 103354 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 453 5 1 3 5.7 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-n1cccc1 10.1016/j.bmc.2008.08.006
CHEMBL3084566 103354 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 453 5 1 3 5.7 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-n1cccc1 10.1016/j.bmc.2008.08.006
76327880 103366 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 485 5 1 3 5.1 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084578 103366 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 485 5 1 3 5.1 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCCC1 10.1016/j.bmc.2008.08.006
44281943 100233 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 387 6 1 5 4.5 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1cnco1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL288554 100233 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 387 6 1 5 4.5 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1cnco1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
71453334 81492 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 407 6 2 3 4.5 COCc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160097 81492 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 407 6 2 3 4.5 COCc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
76316938 103355 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 499 5 1 3 5.5 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084567 103355 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 499 5 1 3 5.5 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
44512619 103369 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 516 5 1 4 4.2 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1cc[n+]([O-])cc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084581 103369 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 516 5 1 4 4.2 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1cc[n+]([O-])cc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
45270199 196418 0 None 47 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 516 5 1 4 4.2 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1cc[n+]([O-])cc1C(=O)N1CCCCC1 10.1016/j.bmc.2009.06.066
CHEMBL562897 196418 0 None 47 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 516 5 1 4 4.2 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1cc[n+]([O-])cc1C(=O)N1CCCCC1 10.1016/j.bmc.2009.06.066
44401561 124121 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL363373 124121 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 10.1021/jm049530m
45271882 195259 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 366 4 1 2 4.1 O=C(N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccc(F)cc1 10.1016/j.bmc.2009.06.066
CHEMBL551134 195259 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 366 4 1 2 4.1 O=C(N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccc(F)cc1 10.1016/j.bmc.2009.06.066
71455029 81471 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 464 7 2 4 3.8 CN(C)C(=O)COc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2159869 81471 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 464 7 2 4 3.8 CN(C)C(=O)COc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
70696753 76145 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 500 5 2 3 5.3 O=C(Nc1ccccc1)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
CHEMBL2057762 76145 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 500 5 2 3 5.3 O=C(Nc1ccccc1)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
44452009 95947 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 392 5 1 3 4.4 COc1ccc(C(=O)NC2CCN(Cc3ccc4cc(F)ccc4c3)CC2)cc1 10.1016/j.bmc.2007.10.003
CHEMBL259409 95947 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 392 5 1 3 4.4 COc1ccc(C(=O)NC2CCN(Cc3ccc4cc(F)ccc4c3)CC2)cc1 10.1016/j.bmc.2007.10.003
10474776 113657 42 None - 1 Human 7.6 pIC50 = 7.6 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL33227 113657 42 None - 1 Human 7.6 pIC50 = 7.6 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
71453337 81506 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 540 5 2 5 3.8 O=C(NC1CCN(S(=O)(=O)c2ccccc2O)CC1)N1CCCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmcl.2012.09.035
CHEMBL2160110 81506 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 540 5 2 5 3.8 O=C(NC1CCN(S(=O)(=O)c2ccccc2O)CC1)N1CCCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmcl.2012.09.035
44290039 178802 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL46905 178802 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
44282005 123753 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 520 9 3 5 4.2 COc1ccc(C[C@H](NC(=O)c2cccc3ccccc23)C(=O)N[C@@H](C)C(=O)Nc2ccc(C#N)cc2)cc1 10.1016/s0960-894x(01)00249-9
CHEMBL36223 123753 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 520 9 3 5 4.2 COc1ccc(C[C@H](NC(=O)c2cccc3ccccc23)C(=O)N[C@@H](C)C(=O)Nc2ccc(C#N)cc2)cc1 10.1016/s0960-894x(01)00249-9
45269291 196440 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 427 5 2 4 3.2 O=C(N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)NS(=O)(=O)c1ccccc1 10.1016/j.bmc.2009.06.066
CHEMBL563019 196440 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 427 5 2 4 3.2 O=C(N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)NS(=O)(=O)c1ccccc1 10.1016/j.bmc.2009.06.066
45269385 196480 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 424 5 1 2 5.7 O=C(N[C@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
CHEMBL563319 196480 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 424 5 1 2 5.7 O=C(N[C@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
44281668 110422 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 500 8 3 4 4.4 C[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1cccnc1 10.1016/s0960-894x(01)00249-9
CHEMBL32451 110422 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 500 8 3 4 4.4 C[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1cccnc1 10.1016/s0960-894x(01)00249-9
44452168 95851 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 464 5 1 2 6.6 O=C(NC1C[C@@H]2CC[C@@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2007.10.003
CHEMBL258996 95851 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 464 5 1 2 6.6 O=C(NC1C[C@@H]2CC[C@@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2007.10.003
76320671 103364 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 471 5 1 3 5.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1N1CCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084576 103364 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 471 5 1 3 5.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1N1CCCCC1 10.1016/j.bmc.2008.08.006
71456839 81496 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 467 10 3 5 3.8 O=C(Nc1ccccc1OCCOCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160100 81496 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 467 10 3 5 3.8 O=C(Nc1ccccc1OCCOCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
44452220 161276 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 452 5 1 2 6.4 CC1(NC(=O)c2ccccc2-c2ccccc2)CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
CHEMBL412072 161276 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 452 5 1 2 6.4 CC1(NC(=O)c2ccccc2-c2ccccc2)CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
76313428 103352 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 465 5 1 3 6.0 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1cccnc1 10.1016/j.bmc.2008.08.006
CHEMBL3084564 103352 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 465 5 1 3 6.0 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1cccnc1 10.1016/j.bmc.2008.08.006
70688469 76187 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 534 5 2 3 5.9 O=C(Nc1ccccc1Cl)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
CHEMBL2058070 76187 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 534 5 2 3 5.9 O=C(Nc1ccccc1Cl)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
44452119 96354 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 380 4 1 2 4.5 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1F 10.1016/j.bmc.2007.10.003
CHEMBL261574 96354 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 380 4 1 2 4.5 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1F 10.1016/j.bmc.2007.10.003
44281859 109825 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 463 9 2 6 3.2 CCOC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL32334 109825 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 463 9 2 6 3.2 CCOC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
44289926 177559 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 453 9 2 4 4.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL46404 177559 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 453 9 2 4 4.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
44289927 168327 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL43423 168327 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
45268462 196215 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 517 6 2 5 4.2 COc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c(O)c1 10.1016/j.bmc.2009.06.066
CHEMBL561535 196215 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 517 6 2 5 4.2 COc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c(O)c1 10.1016/j.bmc.2009.06.066
45269302 196116 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 531 7 1 5 4.5 COc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)cc1OC 10.1016/j.bmc.2009.06.066
CHEMBL560995 196116 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 531 7 1 5 4.5 COc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)cc1OC 10.1016/j.bmc.2009.06.066
70688470 76190 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 542 6 2 3 6.4 CC(C)c1ccccc1NC(=O)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
CHEMBL2058073 76190 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 542 6 2 3 6.4 CC(C)c1ccccc1NC(=O)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
9892753 16500 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 516 8 3 4 5.5 CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm049530m
CHEMBL123611 16500 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 516 8 3 4 5.5 CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm049530m
44281667 115661 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 524 10 3 5 3.9 CC(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)NCc1ccccc1 10.1016/s0960-894x(01)00249-9
CHEMBL33537 115661 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 524 10 3 5 3.9 CC(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)NCc1ccccc1 10.1016/s0960-894x(01)00249-9
45273705 195798 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 376 5 1 2 4.3 O=C(Cc1ccccc1)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2009.06.066
CHEMBL557936 195798 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 376 5 1 2 4.3 O=C(Cc1ccccc1)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2009.06.066
10050884 154652 14 None -204 3 Mouse 7.5 pIC50 = 7.5 Functional
Antagonist activity at CCR3 receptor in mouse eosinophil assessed as as inhibition of chemotaxisAntagonist activity at CCR3 receptor in mouse eosinophil assessed as as inhibition of chemotaxis
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
CHEMBL399495 154652 14 None -204 3 Mouse 7.5 pIC50 = 7.5 Functional
Antagonist activity at CCR3 receptor in mouse eosinophil assessed as as inhibition of chemotaxisAntagonist activity at CCR3 receptor in mouse eosinophil assessed as as inhibition of chemotaxis
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
70684230 76189 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 530 6 2 4 5.3 COc1ccccc1NC(=O)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
CHEMBL2058072 76189 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 530 6 2 4 5.3 COc1ccccc1NC(=O)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
70682099 76135 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 532 4 1 3 5.2 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057752 76135 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 532 4 1 3 5.2 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.06.042
10474776 113657 42 None - 1 Human 7.5 pIC50 = 7.5 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL33227 113657 42 None - 1 Human 7.5 pIC50 = 7.5 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
45268519 196273 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 409 5 0 2 6.4 O=C(c1ccccc1-c1ccccc1)C1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL561941 196273 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 409 5 0 2 6.4 O=C(c1ccccc1-c1ccccc1)C1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
44281966 99812 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 403 6 1 5 4.9 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1nccs1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL285444 99812 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 403 6 1 5 4.9 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1nccs1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
44452361 96508 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 338 5 1 2 3.7 O=C(NC1CCN(C/C=C/c2ccc(F)cc2)CC1)c1ccccc1 10.1016/j.bmc.2007.10.003
CHEMBL262588 96508 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 338 5 1 2 3.7 O=C(NC1CCN(C/C=C/c2ccc(F)cc2)CC1)c1ccccc1 10.1016/j.bmc.2007.10.003
10474776 113657 42 None - 1 Human 7.5 pIC50 = 7.5 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand, using [Ca2+] mobilization assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand, using [Ca2+] mobilization assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL33227 113657 42 None - 1 Human 7.5 pIC50 = 7.5 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand, using [Ca2+] mobilization assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand, using [Ca2+] mobilization assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
11442439 124057 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 455 6 2 2 5.9 Cc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1F 10.1021/jm049530m
CHEMBL363166 124057 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 455 6 2 2 5.9 Cc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1F 10.1021/jm049530m
44386406 62487 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 461 9 2 6 3.3 C=C(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)OCC 10.1016/s0960-894x(01)00249-9
CHEMBL178019 62487 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 461 9 2 6 3.3 C=C(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)OCC 10.1016/s0960-894x(01)00249-9
6918497 113430 2 None -213 4 Mouse 6.5 pIC50 = 6.5 Functional
Inhibitory activity against I-Eotaxin induced [Ca2+] response in mouse CCR3 receptorInhibitory activity against I-Eotaxin induced [Ca2+] response in mouse CCR3 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL277930 113430 2 None -213 4 Mouse 6.5 pIC50 = 6.5 Functional
Inhibitory activity against I-Eotaxin induced [Ca2+] response in mouse CCR3 receptorInhibitory activity against I-Eotaxin induced [Ca2+] response in mouse CCR3 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL331897 113430 2 None -213 4 Mouse 6.5 pIC50 = 6.5 Functional
Inhibitory activity against I-Eotaxin induced [Ca2+] response in mouse CCR3 receptorInhibitory activity against I-Eotaxin induced [Ca2+] response in mouse CCR3 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
44452044 156087 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 392 5 1 3 4.4 COc1cccc(C(=O)NC2CCN(Cc3ccc4cc(F)ccc4c3)CC2)c1 10.1016/j.bmc.2007.10.003
CHEMBL406296 156087 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 392 5 1 3 4.4 COc1cccc(C(=O)NC2CCN(Cc3ccc4cc(F)ccc4c3)CC2)c1 10.1016/j.bmc.2007.10.003
70690518 76131 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 555 4 1 4 5.0 CN1CN(c2ccccc2)C2(CCN(C(=O)NC3C[C@H]4CC[C@H](C3)N4Cc3ccc4cc(F)ccc4c3)CC2)C1=O 10.1016/j.bmcl.2012.06.042
CHEMBL2057748 76131 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 555 4 1 4 5.0 CN1CN(c2ccccc2)C2(CCN(C(=O)NC3C[C@H]4CC[C@H](C3)N4Cc3ccc4cc(F)ccc4c3)CC2)C1=O 10.1016/j.bmcl.2012.06.042
10474776 113657 42 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using [Ca2+] mobilization assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using [Ca2+] mobilization assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL33227 113657 42 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using [Ca2+] mobilization assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using [Ca2+] mobilization assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
44451928 159163 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 438 5 1 2 6.0 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2007.10.003
CHEMBL409830 159163 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 438 5 1 2 6.0 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2007.10.003
44451928 159163 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 438 5 1 2 6.0 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
CHEMBL409830 159163 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 438 5 1 2 6.0 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
45268458 196743 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 517 6 2 5 4.2 COc1cccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c1O 10.1016/j.bmc.2009.06.066
CHEMBL565165 196743 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 517 6 2 5 4.2 COc1cccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c1O 10.1016/j.bmc.2009.06.066
71460524 81505 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 474 5 1 3 4.9 O=C(NC1CCN(Cc2ccccc2)CC1)N1CCCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmcl.2012.09.035
CHEMBL2160109 81505 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 474 5 1 3 4.9 O=C(NC1CCN(Cc2ccccc2)CC1)N1CCCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmcl.2012.09.035
70686357 76136 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 529 4 2 4 4.6 Nc1ccc(C(=O)N2CCCN(C(=O)NC3C[C@H]4CC[C@H](C3)N4Cc3ccc4cc(F)ccc4c3)CC2)cc1 10.1016/j.bmcl.2012.06.042
CHEMBL2057753 76136 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 529 4 2 4 4.6 Nc1ccc(C(=O)N2CCCN(C(=O)NC3C[C@H]4CC[C@H](C3)N4Cc3ccc4cc(F)ccc4c3)CC2)cc1 10.1016/j.bmcl.2012.06.042
44282280 120393 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 463 9 2 6 3.2 CCOC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL35341 120393 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 463 9 2 6 3.2 CCOC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
11329244 71116 11 None 20 7 Human 8.4 pIC50 = 8.4 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
CHEMBL195433 71116 11 None 20 7 Human 8.4 pIC50 = 8.4 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
11340670 127234 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 483 7 2 3 5.8 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F 10.1021/jm049530m
CHEMBL365820 127234 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 483 7 2 3 5.8 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F 10.1021/jm049530m
11397114 133469 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2cn[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL3706810 133469 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2cn[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44401123 136280 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 516 7 2 5 4.9 N#CC1=CC(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)CC=C1n1cccn1 10.1021/jm049530m
CHEMBL373347 136280 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 516 7 2 5 4.9 N#CC1=CC(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)CC=C1n1cccn1 10.1021/jm049530m
9847583 196466 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 471 5 1 3 4.5 O=C(C=C1CCN(C(=O)c2ccccc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL563189 196466 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 471 5 1 3 4.5 O=C(C=C1CCN(C(=O)c2ccccc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
45273624 195667 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 489 5 1 3 4.7 O=C(C=C1CCN(C(=O)c2ccccc2F)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL556500 195667 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 489 5 1 3 4.7 O=C(C=C1CCN(C(=O)c2ccccc2F)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
70696765 76188 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 545 6 2 5 5.2 O=C(Nc1ccccc1[N+](=O)[O-])[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
CHEMBL2058071 76188 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 545 6 2 5 5.2 O=C(Nc1ccccc1[N+](=O)[O-])[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
25024651 116036 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Inhibition of CCR3 in human eosinophil assessed as inhibition of eotaxin-induced Ca2+ influxInhibition of CCR3 in human eosinophil assessed as inhibition of eotaxin-induced Ca2+ influx
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
CHEMBL3355956 116036 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Inhibition of CCR3 in human eosinophil assessed as inhibition of eotaxin-induced Ca2+ influxInhibition of CCR3 in human eosinophil assessed as inhibition of eotaxin-induced Ca2+ influx
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
44281706 111558 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 496 9 3 5 3.8 O=C(CNC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)Nc1ccccc1 10.1016/s0960-894x(01)00249-9
CHEMBL32806 111558 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 496 9 3 5 3.8 O=C(CNC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)Nc1ccccc1 10.1016/s0960-894x(01)00249-9
11227406 94345 2 None -107 4 Mouse 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in BALB/c mouse eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in BALB/c mouse eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
CHEMBL250689 94345 2 None -107 4 Mouse 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in BALB/c mouse eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in BALB/c mouse eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
71460504 81466 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 369 4 2 2 4.2 O=C(NC1CCCCC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2159864 81466 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 369 4 2 2 4.2 O=C(NC1CCCCC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
11227406 94345 2 None -107 4 Mouse 7.4 pIC50 = 7.4 Functional
Inhibition of eotaxin-induced chemotaxis of mouse eosinophilsInhibition of eotaxin-induced chemotaxis of mouse eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL250689 94345 2 None -107 4 Mouse 7.4 pIC50 = 7.4 Functional
Inhibition of eotaxin-induced chemotaxis of mouse eosinophilsInhibition of eotaxin-induced chemotaxis of mouse eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
71456816 81468 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 407 6 3 3 3.9 O=C(Nc1ccccc1CCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2159866 81468 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 407 6 3 3 3.9 O=C(Nc1ccccc1CCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
71455044 81501 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 450 8 2 4 4.3 CN(C)CCOc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160105 81501 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 450 8 2 4 4.3 CN(C)CCOc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
71453336 81502 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 436 7 3 4 3.2 NC(=O)COc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160106 81502 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 436 7 3 4 3.2 NC(=O)COc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
76327879 103365 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 527 6 1 3 6.3 CN(C(=O)c1ccccc1C(=O)N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)C1CCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084577 103365 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 527 6 1 3 6.3 CN(C(=O)c1ccccc1C(=O)N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)C1CCCCC1 10.1016/j.bmc.2008.08.006
70682098 76133 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 545 4 2 4 5.3 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCC(n2c(=O)[nH]c3c(F)cccc32)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057750 76133 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 545 4 2 4 5.3 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCC(n2c(=O)[nH]c3c(F)cccc32)CC1 10.1016/j.bmcl.2012.06.042
70682101 76141 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 530 4 2 4 4.7 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2ccc(O)cc2)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057758 76141 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 530 4 2 4 4.7 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2ccc(O)cc2)CC1 10.1016/j.bmcl.2012.06.042
44281852 99682 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 511 8 3 3 5.1 Cc1ccc(C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](C)C(=O)Nc2ccc(Cl)cc2)c(C)c1 10.1016/s0960-894x(01)00249-9
CHEMBL284531 99682 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 511 8 3 3 5.1 Cc1ccc(C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](C)C(=O)Nc2ccc(Cl)cc2)c(C)c1 10.1016/s0960-894x(01)00249-9
44281944 121793 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 529 9 3 4 5.0 COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)c2cccc3ccccc23)cc1 10.1016/s0960-894x(01)00249-9
CHEMBL35896 121793 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 529 9 3 4 5.0 COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)c2cccc3ccccc23)cc1 10.1016/s0960-894x(01)00249-9
70692666 76143 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 554 5 1 3 5.5 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)C2(c3ccccc3)CC2)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057760 76143 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 554 5 1 3 5.5 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)C2(c3ccccc3)CC2)CC1 10.1016/j.bmcl.2012.06.042
45273639 196425 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 517 6 2 5 4.2 COc1cccc(O)c1C(=O)N1CCC(=CC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 10.1016/j.bmc.2009.06.066
CHEMBL562922 196425 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 517 6 2 5 4.2 COc1cccc(O)c1C(=O)N1CCC(=CC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 10.1016/j.bmc.2009.06.066
44452172 95852 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 378 4 1 3 5.2 O=C(Nc1ccccc1)OC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
CHEMBL258997 95852 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 378 4 1 3 5.2 O=C(Nc1ccccc1)OC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
76324312 103356 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 514 5 1 4 4.3 CN1CCN(C(=O)c2ccccc2C(=O)N[C@H]2C[C@@H]3CC[C@H](C2)N3Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2008.08.006
CHEMBL3084568 103356 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 514 5 1 4 4.3 CN1CCN(C(=O)c2ccccc2C(=O)N[C@H]2C[C@@H]3CC[C@H](C2)N3Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2008.08.006
10474776 113657 42 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL33227 113657 42 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
9957612 163262 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 499 8 3 3 5.0 C[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccccc1 10.1016/s0960-894x(01)00249-9
CHEMBL418588 163262 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 499 8 3 3 5.0 C[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccccc1 10.1016/s0960-894x(01)00249-9
45273632 195703 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2cccc(O)c2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL556916 195703 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2cccc(O)c2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
44455847 155446 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 501 9 2 6 4.7 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL403839 155446 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 501 9 2 6 4.7 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
45272697 195621 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 501 6 1 4 4.5 COc1ccccc1C(=O)N1CCC(=CC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 10.1016/j.bmc.2009.06.066
CHEMBL556227 195621 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 501 6 1 4 4.5 COc1ccccc1C(=O)N1CCC(=CC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 10.1016/j.bmc.2009.06.066
45273698 196426 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2ccc(O)cc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL562923 196426 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2ccc(O)cc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
45273689 195726 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 501 6 1 4 4.5 COc1cccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c1 10.1016/j.bmc.2009.06.066
CHEMBL557118 195726 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 501 6 1 4 4.5 COc1cccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c1 10.1016/j.bmc.2009.06.066
71455028 81467 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 363 4 2 2 4.4 O=C(Nc1ccccc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2159865 81467 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 363 4 2 2 4.4 O=C(Nc1ccccc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
71453335 81499 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 437 8 3 4 4.1 O=C(Nc1ccccc1OCCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160103 81499 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 437 8 3 4 4.1 O=C(Nc1ccccc1OCCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
11179592 69592 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 501 6 2 2 6.2 O=C(Nc1ccc(Br)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL193442 69592 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 501 6 2 2 6.2 O=C(Nc1ccc(Br)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11316656 70262 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 441 6 2 2 5.6 O=C(Nc1ccc(F)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL194141 70262 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 441 6 2 2 5.6 O=C(Nc1ccc(F)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44281755 99687 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 502 9 3 6 3.8 COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2cscn2)NC(=O)c2cccc3ccccc23)cc1 10.1016/s0960-894x(01)00249-9
CHEMBL284576 99687 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 502 9 3 6 3.8 COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2cscn2)NC(=O)c2cccc3ccccc23)cc1 10.1016/s0960-894x(01)00249-9
44281999 121857 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 459 8 1 7 4.6 CCOC(=O)c1coc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 10.1016/s0960-894x(01)00249-9
CHEMBL35900 121857 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 459 8 1 7 4.6 CCOC(=O)c1coc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 10.1016/s0960-894x(01)00249-9
71462226 81493 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 421 7 3 3 4.3 O=C(Nc1ccccc1CCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160098 81493 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 421 7 3 3 4.3 O=C(Nc1ccccc1CCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
70694702 76138 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 548 4 2 4 4.9 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2c(O)cccc2F)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057755 76138 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 548 4 2 4 4.9 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2c(O)cccc2F)CC1 10.1016/j.bmcl.2012.06.042
70690519 76132 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 527 4 2 4 5.2 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057749 76132 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 527 4 2 4 5.2 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 10.1016/j.bmcl.2012.06.042
10474776 113657 42 None - 1 Human 7.3 pIC50 = 7.3 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL33227 113657 42 None - 1 Human 7.3 pIC50 = 7.3 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
45271905 195021 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 438 5 1 2 6.0 O=C(NC1CCCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
CHEMBL549302 195021 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 438 5 1 2 6.0 O=C(NC1CCCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
70690520 76144 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 550 5 1 4 4.6 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(S(=O)(=O)c2ccccc2)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057761 76144 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 550 5 1 4 4.6 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(S(=O)(=O)c2ccccc2)CC1 10.1016/j.bmcl.2012.06.042
9952288 110504 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 389 6 1 5 3.5 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C1=NCCO1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL32493 110504 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 389 6 1 5 3.5 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C1=NCCO1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
76324313 103361 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 465 5 1 3 6.0 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccn1 10.1016/j.bmc.2008.08.006
CHEMBL3084573 103361 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 465 5 1 3 6.0 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccn1 10.1016/j.bmc.2008.08.006
70690517 76130 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 541 4 2 4 4.6 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.bmcl.2012.06.042
CHEMBL2057747 76130 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 541 4 2 4 4.6 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.bmcl.2012.06.042
45268467 196242 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 505 5 2 4 4.4 O=C(C=C1CCN(C(=O)c2ccc(F)cc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL561740 196242 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 505 5 2 4 4.4 O=C(C=C1CCN(C(=O)c2ccc(F)cc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
6918497 113430 2 None 1 4 Human 8.2 pIC50 = 8.2 Functional
Inhibitory activity against I-Eotaxin induced [Ca2+] response in human CCR3 receptorInhibitory activity against I-Eotaxin induced [Ca2+] response in human CCR3 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL277930 113430 2 None 1 4 Human 8.2 pIC50 = 8.2 Functional
Inhibitory activity against I-Eotaxin induced [Ca2+] response in human CCR3 receptorInhibitory activity against I-Eotaxin induced [Ca2+] response in human CCR3 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL331897 113430 2 None 1 4 Human 8.2 pIC50 = 8.2 Functional
Inhibitory activity against I-Eotaxin induced [Ca2+] response in human CCR3 receptorInhibitory activity against I-Eotaxin induced [Ca2+] response in human CCR3 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
44455872 155515 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 467 9 2 4 5.1 CC(=O)c1cc(NC(=O)N[C@@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL404202 155515 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 467 9 2 4 5.1 CC(=O)c1cc(NC(=O)N[C@@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
44281987 99648 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 542 9 3 4 5.4 C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccc(-c2ccccc2)cc1 10.1016/s0960-894x(01)00249-9
CHEMBL284313 99648 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 542 9 3 4 5.4 C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccc(-c2ccccc2)cc1 10.1016/s0960-894x(01)00249-9
44281794 168011 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 524 9 2 5 4.3 C[C@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)N(C)c1ccccc1 10.1016/s0960-894x(01)00249-9
CHEMBL432088 168011 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 524 9 2 5 4.3 C[C@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)N(C)c1ccccc1 10.1016/s0960-894x(01)00249-9
44452304 157845 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 348 5 1 2 4.7 Fc1ccc2cc(CN3CCC(NCc4ccccc4)CC3)ccc2c1 10.1016/j.bmc.2007.10.003
CHEMBL408368 157845 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 348 5 1 2 4.7 Fc1ccc2cc(CN3CCC(NCc4ccccc4)CC3)ccc2c1 10.1016/j.bmc.2007.10.003
71449695 81503 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 416 5 0 2 5.0 O=C1N(CCc2ccccc2)CCC12CCN(Cc1ccc3cc(F)ccc3c1)CC2 10.1016/j.bmcl.2012.09.035
CHEMBL2160107 81503 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 416 5 0 2 5.0 O=C1N(CCc2ccccc2)CCC12CCN(Cc1ccc3cc(F)ccc3c1)CC2 10.1016/j.bmcl.2012.09.035
9826988 76084 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 492 7 0 7 4.2 Cc1nnc2n(CCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)c(=O)c3ccccc3n12 10.1016/j.bmcl.2012.06.042
CHEMBL2057489 76084 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 492 7 0 7 4.2 Cc1nnc2n(CCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)c(=O)c3ccccc3n12 10.1016/j.bmcl.2012.06.042
76320667 103351 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 465 5 1 3 6.0 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccncc1 10.1016/j.bmc.2008.08.006
CHEMBL3084563 103351 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 465 5 1 3 6.0 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccncc1 10.1016/j.bmc.2008.08.006
24882359 193047 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 464 5 1 2 6.6 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2008.08.006
CHEMBL522295 193047 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 464 5 1 2 6.6 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2008.08.006
70694701 76137 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 582 4 1 3 6.3 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2c(Cl)cccc2Cl)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057754 76137 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 582 4 1 3 6.3 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2c(Cl)cccc2Cl)CC1 10.1016/j.bmcl.2012.06.042
70696752 76142 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 530 4 2 4 4.7 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2ccccc2O)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057759 76142 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 530 4 2 4 4.7 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2ccccc2O)CC1 10.1016/j.bmcl.2012.06.042
44452086 157887 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 380 4 1 2 4.5 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2007.10.003
CHEMBL408407 157887 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 380 4 1 2 4.5 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2007.10.003
44452086 157887 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 380 4 1 2 4.5 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2009.06.066
CHEMBL408407 157887 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 380 4 1 2 4.5 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2009.06.066
44281775 115563 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 524 9 2 5 4.6 C[C@@H](C(=O)Nc1ccccc1)N(C)C(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL33534 115563 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 524 9 2 5 4.6 C[C@@H](C(=O)Nc1ccccc1)N(C)C(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
44281951 120227 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 475 8 1 7 5.1 CCOC(=O)c1csc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 10.1016/s0960-894x(01)00249-9
CHEMBL35217 120227 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 475 8 1 7 5.1 CCOC(=O)c1csc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 10.1016/s0960-894x(01)00249-9
44281686 112026 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 462 9 3 5 2.7 CCNC(=O)C(C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL32895 112026 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 462 9 3 5 2.7 CCNC(=O)C(C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
44452120 156229 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 380 4 1 2 4.5 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1cccc(F)c1 10.1016/j.bmc.2007.10.003
CHEMBL406468 156229 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 380 4 1 2 4.5 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1cccc(F)c1 10.1016/j.bmc.2007.10.003
76313429 103357 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 501 5 1 4 4.4 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCOCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084569 103357 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 501 5 1 4 4.4 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCOCC1 10.1016/j.bmc.2008.08.006
11953409 94216 0 None -7 4 Mouse 8.2 pIC50 = 8.2 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in BALB/c mouse eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in BALB/c mouse eosinophils
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249854 94216 0 None -7 4 Mouse 8.2 pIC50 = 8.2 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in BALB/c mouse eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in BALB/c mouse eosinophils
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
45269320 196592 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 521 5 2 4 4.9 O=C(C=C1CCN(C(=O)c2ccc(Cl)cc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL564022 196592 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 521 5 2 4 4.9 O=C(C=C1CCN(C(=O)c2ccc(Cl)cc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
44281774 116667 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 501 9 3 4 5.1 COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](CC2CCCCC2)NC(=O)c2cccc3ccccc23)cc1 10.1016/s0960-894x(01)00249-9
CHEMBL33708 116667 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 501 9 3 4 5.1 COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](CC2CCCCC2)NC(=O)c2cccc3ccccc23)cc1 10.1016/s0960-894x(01)00249-9
71456840 81497 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 437 8 2 4 4.4 COCCOc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160101 81497 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 437 8 2 4 4.4 COCCOc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
44387842 131301 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 369 5 2 3 4.2 CC(=O)c1cccc(NC(=O)NN2CCCCC2Cc2ccc(F)cc2)c1 10.1021/jm049530m
CHEMBL368683 131301 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 369 5 2 3 4.2 CC(=O)c1cccc(NC(=O)NN2CCCCC2Cc2ccc(F)cc2)c1 10.1021/jm049530m
44452083 96177 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 392 5 1 3 4.4 COc1ccccc1C(=O)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
CHEMBL260649 96177 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 392 5 1 3 4.4 COc1ccccc1C(=O)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
44281872 109358 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 522 8 2 6 6.2 O=C(Nc1ccccc1)c1csc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 10.1016/s0960-894x(01)00249-9
CHEMBL32191 109358 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 522 8 2 6 6.2 O=C(Nc1ccccc1)c1csc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 10.1016/s0960-894x(01)00249-9
70684221 76129 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 461 3 1 2 5.4 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCc2cc(F)ccc2C1 10.1016/j.bmcl.2012.06.042
CHEMBL2057746 76129 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 461 3 1 2 5.4 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCc2cc(F)ccc2C1 10.1016/j.bmcl.2012.06.042
11227406 94345 2 None 107 4 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at CCR3 in human eosinophils assessed as eotaxin-induced calcium mobilization by FLIPR assayAntagonist activity at CCR3 in human eosinophils assessed as eotaxin-induced calcium mobilization by FLIPR assay
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
CHEMBL250689 94345 2 None 107 4 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at CCR3 in human eosinophils assessed as eotaxin-induced calcium mobilization by FLIPR assayAntagonist activity at CCR3 in human eosinophils assessed as eotaxin-induced calcium mobilization by FLIPR assay
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
70696751 76134 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 542 4 3 5 4.7 Nc1ccc2c(c1)[nH]c(=O)n2C1CCN(C(=O)NC2C[C@H]3CC[C@H](C2)N3Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057751 76134 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 542 4 3 5 4.7 Nc1ccc2c(c1)[nH]c(=O)n2C1CCN(C(=O)NC2C[C@H]3CC[C@H](C2)N3Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmcl.2012.06.042
11227406 94345 2 None 107 4 Human 8.1 pIC50 = 8.1 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL250689 94345 2 None 107 4 Human 8.1 pIC50 = 8.1 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
44512617 195338 0 None 79 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL551735 195338 0 None 79 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
22393430 168702 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assay
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL43677 168702 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assay
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
44281754 113178 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 506 8 3 5 4.4 C[C@H](NC(=O)[C@H](Cc1cscn1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccc(Cl)cc1 10.1016/s0960-894x(01)00249-9
CHEMBL33144 113178 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 506 8 3 5 4.4 C[C@H](NC(=O)[C@H](Cc1cscn1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccc(Cl)cc1 10.1016/s0960-894x(01)00249-9
44452248 96232 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 376 4 0 2 4.7 CN(C(=O)c1ccccc1)C1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
CHEMBL260899 96232 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 376 4 0 2 4.7 CN(C(=O)c1ccccc1)C1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
44295672 188756 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
In vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assay
ChEMBL 439 6 1 3 5.0 COc1cccc(NC(=O)N2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50535 188756 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
In vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assay
ChEMBL 439 6 1 3 5.0 COc1cccc(NC(=O)N2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
44452280 95810 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 398 5 1 3 3.9 O=S(=O)(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1 10.1016/j.bmc.2007.10.003
CHEMBL258790 95810 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 398 5 1 3 3.9 O=S(=O)(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1 10.1016/j.bmc.2007.10.003
76313430 103360 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 500 5 1 4 4.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1cnccc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084572 103360 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 500 5 1 4 4.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1cnccc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
76320668 103353 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 471 5 1 4 6.0 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1nccs1 10.1016/j.bmc.2008.08.006
CHEMBL3084565 103353 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 471 5 1 4 6.0 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1nccs1 10.1016/j.bmc.2008.08.006
71451489 81469 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 451 9 3 4 4.5 O=C(Nc1ccccc1OCCCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2159867 81469 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 451 9 3 4 4.5 O=C(Nc1ccccc1OCCCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
44282047 163167 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 520 9 3 5 4.2 COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)c2cccc3ccccc23)cc1 10.1016/s0960-894x(01)00249-9
CHEMBL418041 163167 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 520 9 3 5 4.2 COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)c2cccc3ccccc23)cc1 10.1016/s0960-894x(01)00249-9
45273619 196478 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 485 6 1 3 4.8 O=C(/C=C/C1CCN(C(=O)c2ccccc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL563303 196478 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 485 6 1 3 4.8 O=C(/C=C/C1CCN(C(=O)c2ccccc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
70688460 76148 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 578 5 2 3 6.1 O=C(Nc1ccc(Br)cc1)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
CHEMBL2057765 76148 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 578 5 2 3 6.1 O=C(Nc1ccc(Br)cc1)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
76313415 106387 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 466 5 1 4 5.4 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1cncnc1 10.1016/j.bmc.2008.08.006
CHEMBL3084359 106387 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 466 5 1 4 5.4 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1cncnc1 10.1016/j.bmc.2008.08.006
CHEMBL3139342 106387 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 466 5 1 4 5.4 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1cncnc1 10.1016/j.bmc.2008.08.006
3536 3906 0 None -9 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 assessed as inhibition of CCL11-induced chemotaxis by cell based assayAntagonist activity at CCR3 assessed as inhibition of CCL11-induced chemotaxis by cell based assay
ChEMBL 515 5 1 2 7.3 CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 10.1021/jm300682j
44560289 3906 0 None -9 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 assessed as inhibition of CCL11-induced chemotaxis by cell based assayAntagonist activity at CCR3 assessed as inhibition of CCL11-induced chemotaxis by cell based assay
ChEMBL 515 5 1 2 7.3 CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 10.1021/jm300682j
CHEMBL1186993 3906 0 None -9 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 assessed as inhibition of CCL11-induced chemotaxis by cell based assayAntagonist activity at CCR3 assessed as inhibition of CCL11-induced chemotaxis by cell based assay
ChEMBL 515 5 1 2 7.3 CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 10.1021/jm300682j
44451983 159362 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 454 6 1 3 6.2 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1Oc1ccccc1 10.1016/j.bmc.2007.10.003
CHEMBL410041 159362 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 454 6 1 3 6.2 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1Oc1ccccc1 10.1016/j.bmc.2007.10.003
44452198 157972 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 388 5 1 2 4.8 O=C(/C=C/c1ccccc1)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
CHEMBL408486 157972 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 388 5 1 2 4.8 O=C(/C=C/c1ccccc1)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
44452198 157972 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 388 5 1 2 4.8 O=C(/C=C/c1ccccc1)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2009.06.066
CHEMBL408486 157972 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 388 5 1 2 4.8 O=C(/C=C/c1ccccc1)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2009.06.066
76320669 103358 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 500 5 1 4 4.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1cccnc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084570 103358 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 500 5 1 4 4.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1cccnc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
11753159 547 6 None 4 2 Human 7.0 pKd = 7 Functional
Antagonist activity at CCR3 receptor in human polymorphonuclear leukocytes assessed as inhibition of eotaxin-induced CD11b expression after 15 mins by flow cytometric analysisAntagonist activity at CCR3 receptor in human polymorphonuclear leukocytes assessed as inhibition of eotaxin-induced CD11b expression after 15 mins by flow cytometric analysis
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2012.08.124
7679 547 6 None 4 2 Human 7.0 pKd = 7 Functional
Antagonist activity at CCR3 receptor in human polymorphonuclear leukocytes assessed as inhibition of eotaxin-induced CD11b expression after 15 mins by flow cytometric analysisAntagonist activity at CCR3 receptor in human polymorphonuclear leukocytes assessed as inhibition of eotaxin-induced CD11b expression after 15 mins by flow cytometric analysis
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2012.08.124
CHEMBL2158814 547 6 None 4 2 Human 7.0 pKd = 7 Functional
Antagonist activity at CCR3 receptor in human polymorphonuclear leukocytes assessed as inhibition of eotaxin-induced CD11b expression after 15 mins by flow cytometric analysisAntagonist activity at CCR3 receptor in human polymorphonuclear leukocytes assessed as inhibition of eotaxin-induced CD11b expression after 15 mins by flow cytometric analysis
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2012.08.124
16040671 81279 0 None - 0 Human 7.9 pKd = 7.9 Functional
Antagonist activity at CCR3 in human eosinophils assessed as inhibition of CCL24-induced morphological changes by FACS flow cytometric analysisAntagonist activity at CCR3 in human eosinophils assessed as inhibition of CCL24-induced morphological changes by FACS flow cytometric analysis
ChEMBL 502 8 1 4 5.4 Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158791 81279 0 None - 0 Human 7.9 pKd = 7.9 Functional
Antagonist activity at CCR3 in human eosinophils assessed as inhibition of CCL24-induced morphological changes by FACS flow cytometric analysisAntagonist activity at CCR3 in human eosinophils assessed as inhibition of CCL24-induced morphological changes by FACS flow cytometric analysis
ChEMBL 502 8 1 4 5.4 Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
16681693 82572 1 None - 0 Human 8.7 pKi = 8.7 Functional
Antagonist activity at human CCR3 assessed as inhibition of CCL11-induced calcium influx by cell based assayAntagonist activity at human CCR3 assessed as inhibition of CCL11-induced calcium influx by cell based assay
ChEMBL 487 5 1 5 3.6 Cc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)nn1 10.1021/jm300682j
CHEMBL2178580 82572 1 None - 0 Human 8.7 pKi = 8.7 Functional
Antagonist activity at human CCR3 assessed as inhibition of CCL11-induced calcium influx by cell based assayAntagonist activity at human CCR3 assessed as inhibition of CCL11-induced calcium influx by cell based assay
ChEMBL 487 5 1 5 3.6 Cc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)nn1 10.1021/jm300682j
44399573 68036 0 None - 0 Human 7.0 pKi = 7.0 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 465 6 1 3 5.4 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)C1CCCCC1 10.1016/j.bmcl.2005.04.054
CHEMBL191418 68036 0 None - 0 Human 7.0 pKi = 7.0 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 465 6 1 3 5.4 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)C1CCCCC1 10.1016/j.bmcl.2005.04.054
44399538 67536 0 None - 0 Human 6.8 pKi = 6.8 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 524 7 1 4 5.7 O=C(NCC1CCCN(C2CCN(CCc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL189680 67536 0 None - 0 Human 6.8 pKi = 6.8 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 524 7 1 4 5.7 O=C(NCC1CCCN(C2CCN(CCc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
44399469 166126 0 None - 1 Human 7.6 pKi = 7.6 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL426089 166126 0 None - 1 Human 7.6 pKi = 7.6 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
44399385 67627 0 None - 0 Human 7.5 pKi = 7.5 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 498 6 2 3 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2[nH]ccc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL190436 67627 0 None - 0 Human 7.5 pKi = 7.5 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 498 6 2 3 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2[nH]ccc2c1 10.1016/j.bmcl.2005.04.054
11540776 69461 0 None - 0 Human 7.5 pKi = 7.5 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2cccnc12 10.1016/j.bmcl.2005.04.054
CHEMBL193354 69461 0 None - 0 Human 7.5 pKi = 7.5 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2cccnc12 10.1016/j.bmcl.2005.04.054
44399272 67472 0 None - 0 Human 7.5 pKi = 7.5 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1nccc2ccccc12 10.1016/j.bmcl.2005.04.054
CHEMBL189206 67472 0 None - 0 Human 7.5 pKi = 7.5 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1nccc2ccccc12 10.1016/j.bmcl.2005.04.054
11540776 69461 0 None - 0 Human 7.4 pKi = 7.4 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2cccnc12 10.1016/j.bmcl.2005.04.054
CHEMBL193354 69461 0 None - 0 Human 7.4 pKi = 7.4 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2cccnc12 10.1016/j.bmcl.2005.04.054
44399482 166028 0 None - 0 Human 7.4 pKi = 7.4 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 498 6 2 3 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2[nH]ccc12 10.1016/j.bmcl.2005.04.054
CHEMBL425548 166028 0 None - 0 Human 7.4 pKi = 7.4 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 498 6 2 3 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2[nH]ccc12 10.1016/j.bmcl.2005.04.054
44399443 69180 0 None - 0 Human 6.4 pKi = 6.4 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3cc(Cl)ccc3Cl)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL192584 69180 0 None - 0 Human 6.4 pKi = 6.4 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3cc(Cl)ccc3Cl)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
44399574 67791 0 None - 0 Human 6.4 pKi = 6.4 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3cc(Cl)cc(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL190894 67791 0 None - 0 Human 6.4 pKi = 6.4 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3cc(Cl)cc(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
44399389 127506 0 None - 0 Human 7.3 pKi = 7.3 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 499 6 2 4 5.0 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2[nH]cnc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL366143 127506 0 None - 0 Human 7.3 pKi = 7.3 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 499 6 2 4 5.0 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2[nH]cnc2c1 10.1016/j.bmcl.2005.04.054
44399331 127517 0 None - 0 Human 7.3 pKi = 7.3 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 509 6 1 3 6.3 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ccccc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL366199 127517 0 None - 0 Human 7.3 pKi = 7.3 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 509 6 1 3 6.3 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ccccc2c1 10.1016/j.bmcl.2005.04.054
44399395 67592 0 None - 0 Human 7.3 pKi = 7.3 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 524 6 1 4 6.0 CC1(N2CCCC(CNC(=O)c3ccc4ncccc4c3)C2)CCN(Cc2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2005.04.054
CHEMBL190149 67592 0 None - 0 Human 7.3 pKi = 7.3 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 524 6 1 4 6.0 CC1(N2CCCC(CNC(=O)c3ccc4ncccc4c3)C2)CCN(Cc2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2005.04.054
44399552 67460 0 None - 0 Human 6.3 pKi = 6.3 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 397 5 1 3 3.8 CC(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2005.04.054
CHEMBL189158 67460 0 None - 0 Human 6.3 pKi = 6.3 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 397 5 1 3 3.8 CC(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2005.04.054
44399524 135516 0 None - 0 Human 7.2 pKi = 7.2 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 509 6 1 3 6.3 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2ccccc12 10.1016/j.bmcl.2005.04.054
CHEMBL372868 135516 0 None - 0 Human 7.2 pKi = 7.2 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 509 6 1 3 6.3 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2ccccc12 10.1016/j.bmcl.2005.04.054
44399368 67194 0 None - 0 Human 7.2 pKi = 7.2 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 473 6 1 3 5.4 Cc1ccccc1C(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2005.04.054
CHEMBL187779 67194 0 None - 0 Human 7.2 pKi = 7.2 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 473 6 1 3 5.4 Cc1ccccc1C(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2005.04.054
44399303 68091 0 None - 0 Human 8.1 pKi = 8.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 524 6 1 4 5.9 CC1CN(Cc2ccc(Cl)c(Cl)c2)CCC1N1CCCC(CNC(=O)c2ccc3ncccc3c2)C1 10.1016/j.bmcl.2005.04.054
CHEMBL191464 68091 0 None - 0 Human 8.1 pKi = 8.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 524 6 1 4 5.9 CC1CN(Cc2ccc(Cl)c(Cl)c2)CCC1N1CCCC(CNC(=O)c2ccc3ncccc3c2)C1 10.1016/j.bmcl.2005.04.054
44399332 69282 0 None - 0 Human 7.1 pKi = 7.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 524 6 1 4 6.2 CC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCC(CNC(=O)c3ccc4ncccc4c3)C2)CC1 10.1016/j.bmcl.2005.04.054
CHEMBL192757 69282 0 None - 0 Human 7.1 pKi = 7.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 524 6 1 4 6.2 CC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCC(CNC(=O)c3ccc4ncccc4c3)C2)CC1 10.1016/j.bmcl.2005.04.054
44399290 67612 0 None - 0 Human 6.1 pKi = 6.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 538 6 1 4 5.2 O=C(NCC1CCCN(C2CCN(C(=O)Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL190312 67612 0 None - 0 Human 6.1 pKi = 6.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 538 6 1 4 5.2 O=C(NCC1CCCN(C2CCN(C(=O)Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
44399567 67777 0 None - 0 Human 7.1 pKi = 7.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccnc2ccccc12 10.1016/j.bmcl.2005.04.054
CHEMBL190852 67777 0 None - 0 Human 7.1 pKi = 7.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccnc2ccccc12 10.1016/j.bmcl.2005.04.054
44399407 67568 0 None - 0 Human 7.1 pKi = 7.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 487 7 1 3 5.3 Cc1ccccc1CC(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2005.04.054
CHEMBL189917 67568 0 None - 0 Human 7.1 pKi = 7.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 487 7 1 3 5.3 Cc1ccccc1CC(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2005.04.054
44399442 67654 0 None - 0 Human 7.0 pKi = 7.0 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 489 7 1 4 5.1 COc1ccccc1C(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2005.04.054
CHEMBL190646 67654 0 None - 0 Human 7.0 pKi = 7.0 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 489 7 1 4 5.1 COc1ccccc1C(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2005.04.054
44399537 67619 0 None - 0 Human 7.0 pKi = 7.0 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 476 6 1 4 5.0 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)cc3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL190362 67619 0 None - 0 Human 7.0 pKi = 7.0 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 476 6 1 4 5.0 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)cc3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
44399479 67582 0 None - 0 Human 7.0 pKi = 7 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 511 6 1 5 5.0 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cnnc2ccccc12 10.1016/j.bmcl.2005.04.054
CHEMBL190048 67582 0 None - 0 Human 7.0 pKi = 7 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 511 6 1 5 5.0 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cnnc2ccccc12 10.1016/j.bmcl.2005.04.054
3536 3906 0 None -9 2 Human 7.0 pIC50 = 7.0 Functional
Measuring antagonism of CCL11-induced chemotaxis <i>in vitro</i>.Measuring antagonism of CCL11-induced chemotaxis <i>in vitro</i>.
Guide to Pharmacology 515 5 1 2 7.3 CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 10854442
44560289 3906 0 None -9 2 Human 7.0 pIC50 = 7.0 Functional
Measuring antagonism of CCL11-induced chemotaxis <i>in vitro</i>.Measuring antagonism of CCL11-induced chemotaxis <i>in vitro</i>.
Guide to Pharmacology 515 5 1 2 7.3 CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 10854442
CHEMBL1186993 3906 0 None -9 2 Human 7.0 pIC50 = 7.0 Functional
Measuring antagonism of CCL11-induced chemotaxis <i>in vitro</i>.Measuring antagonism of CCL11-induced chemotaxis <i>in vitro</i>.
Guide to Pharmacology 515 5 1 2 7.3 CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 10854442
4382 833 0 None 25 2 Human 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23951310
9680 1898 6 None - 1 Human 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 450 7 3 4 2.8 O=C(NCc1ccc(cc1)C(=O)N)NC[C@H]1OCCN(C1)Cc1ccc(c(c1)Cl)Cl 22931505
9825034 1898 6 None - 1 Human 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 450 7 3 4 2.8 O=C(NCc1ccc(cc1)C(=O)N)NC[C@H]1OCCN(C1)Cc1ccc(c(c1)Cl)Cl 22931505
CHEMBL2178574 1898 6 None - 1 Human 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 450 7 3 4 2.8 O=C(NCc1ccc(cc1)C(=O)N)NC[C@H]1OCCN(C1)Cc1ccc(c(c1)Cl)Cl 22931505
776 853 0 None -1 2 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10488147
776 853 0 None -1 2 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15207250
776 853 0 None -1 2 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16339911
754 830 0 None 5 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9346309
775 849 0 None 316 2 Human 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15207250
775 849 0 None 316 2 Human 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16339911
769 827 0 None 14 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10488147
769 827 0 None 14 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10854442
769 827 0 None 14 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12761559
769 827 0 None 14 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16339911
769 827 0 None 14 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9276730
770 828 0 None 7 2 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16339911
770 828 0 None 7 2 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9276730
773 1937 0 None -12 2 Human 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9789057
10098735 3343 0 None - 1 Human 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 537 10 2 5 6.1 COc1cc(NC(=O)N[C@H](C(C)C)CN2CCC(CC2)Cc2ccc(c(c2)Cl)Cl)cc(c1OC)OC 12070060
789 3343 0 None - 1 Human 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 537 10 2 5 6.1 COc1cc(NC(=O)N[C@H](C(C)C)CN2CCC(CC2)Cc2ccc(c(c2)Cl)Cl)cc(c1OC)OC 12070060
11556309 4120 0 None - 1 Human 7.9 pIC50 None 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 502 5 2 5 3.9 O=C(C=C1CCN(CC1)C(=O)c1ncc(cc1O)C)N[C@@H]1CCN(C1)Cc1ccc2c(c1)ccc(c2)F 16339911
793 4120 0 None - 1 Human 7.9 pIC50 None 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 502 5 2 5 3.9 O=C(C=C1CCN(CC1)C(=O)c1ncc(cc1O)C)N[C@@H]1CCN(C1)Cc1ccc2c(c1)ccc(c2)F 16339911
788 2494 0 None - 1 Human 8.2 pIC50 None 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10640766
10304110 3349 0 None - 1 Human 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 560 11 2 7 5.3 COc1cc(ccc1OC)c1cnc(nc1)SCC(=O)NCC[C@H]1NC[C@@H](C1)Cc1ccc(c(c1)Cl)Cl 12070060
792 3349 0 None - 1 Human 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 560 11 2 7 5.3 COc1cc(ccc1OC)c1cnc(nc1)SCC(=O)NCC[C@H]1NC[C@@H](C1)Cc1ccc(c(c1)Cl)Cl 12070060
10255622 3347 0 None - 1 Human 8.4 pIC50 None 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 505 10 3 6 4.2 COc1cc(NC(=O)N[C@H](C(O)C)CN2CCC(CC2)Cc2ccc(cc2)Cl)cc(c1OC)OC 12070060
791 3347 0 None - 1 Human 8.4 pIC50 None 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 505 10 3 6 4.2 COc1cc(NC(=O)N[C@H](C(O)C)CN2CCC(CC2)Cc2ccc(cc2)Cl)cc(c1OC)OC 12070060
790 3344 0 None - 1 Human 9.0 pIC50 None 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 552 10 2 4 6.3 COc1cc(NC(=O)N[C@H](C(C)C)C[N+]2(C)CCC(CC2)Cc2ccc(c(c2)Cl)Cl)cc(c1OC)OC 12070060
9915610 3344 0 None - 1 Human 9.0 pIC50 None 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 552 10 2 4 6.3 COc1cc(NC(=O)N[C@H](C(C)C)C[N+]2(C)CCC(CC2)Cc2ccc(c(c2)Cl)Cl)cc(c1OC)OC 12070060


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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ity		 Common
name		 GPCRdb
ID		 #Vendors

 Reference
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selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Assay
Type		 Assay
Description		 Source

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weight		 Rot
Bonds		 H don

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38347547 146455 5 None - 0 Human 5.9 pEC50 = 5.9 Binding
Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay
ChEMBL 430 11 0 7 4.5 C=CCc1cc(OC)c(O[C@@H](C)[C@H](OC(C)=O)c2ccc(OC)c(OC)c2)c(OC)c1 10.1021/acs.jnatprod.6b00262
CHEMBL3922119 146455 5 None - 0 Human 5.9 pEC50 = 5.9 Binding
Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay
ChEMBL 430 11 0 7 4.5 C=CCc1cc(OC)c(O[C@@H](C)[C@H](OC(C)=O)c2ccc(OC)c(OC)c2)c(OC)c1 10.1021/acs.jnatprod.6b00262
25751147 149960 3 None - 0 Human 5.8 pEC50 = 5.8 Binding
Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay
ChEMBL 404 10 2 7 3.7 C=CCc1cc(OC)c(O[C@H](C)[C@@H](O)c2cc(OC)c(O)c(OC)c2)c(OC)c1 10.1021/acs.jnatprod.6b00262
CHEMBL3949874 149960 3 None - 0 Human 5.8 pEC50 = 5.8 Binding
Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay
ChEMBL 404 10 2 7 3.7 C=CCc1cc(OC)c(O[C@H](C)[C@@H](O)c2cc(OC)c(O)c(OC)c2)c(OC)c1 10.1021/acs.jnatprod.6b00262
124396489 144464 6 None - 0 Human 5.8 pEC50 = 5.8 Binding
Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay
ChEMBL 356 5 1 5 4.7 C/C=C/c1cc(OC)c2c(c1)[C@@H](C)[C@H](c1cc(OC)c(O)c(OC)c1)O2 10.1021/acs.jnatprod.6b00262
CHEMBL3906647 144464 6 None - 0 Human 5.8 pEC50 = 5.8 Binding
Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay
ChEMBL 356 5 1 5 4.7 C/C=C/c1cc(OC)c2c(c1)[C@@H](C)[C@H](c1cc(OC)c(O)c(OC)c1)O2 10.1021/acs.jnatprod.6b00262
10474776 113657 42 None - 0 Human 6.1 pEC50 = 6.1 Binding
Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1021/acs.jnatprod.6b00262
CHEMBL33227 113657 42 None - 0 Human 6.1 pEC50 = 6.1 Binding
Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1021/acs.jnatprod.6b00262
11272103 124375 0 None - 0 Rat 11.0 pIC50 = 11 Binding
Inhibition of eotaxin-induced chemotaxis of rat eosinophilsInhibition of eotaxin-induced chemotaxis of rat eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL363840 124375 0 None - 0 Rat 11.0 pIC50 = 11 Binding
Inhibition of eotaxin-induced chemotaxis of rat eosinophilsInhibition of eotaxin-induced chemotaxis of rat eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
44570583 190942 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 550 7 2 8 3.3 CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
CHEMBL505914 190942 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 550 7 2 8 3.3 CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
CHEMBL518571 190942 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 550 7 2 8 3.3 CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
44570583 190942 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 550 7 2 8 3.3 CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
CHEMBL505914 190942 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 550 7 2 8 3.3 CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
CHEMBL518571 190942 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 550 7 2 8 3.3 CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
44593547 176866 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 538 10 2 8 3.3 CCN(CCCc1ccc(F)cc1)CC1OC(=O)N(C)CC1(C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2008.11.002
CHEMBL461445 176866 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 538 10 2 8 3.3 CCN(CCCc1ccc(F)cc1)CC1OC(=O)N(C)CC1(C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2008.11.002
44447136 94552 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 469 11 3 7 2.8 CCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL251837 94552 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 469 11 3 7 2.8 CCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44447381 94891 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 511 12 3 7 3.8 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)CCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254095 94891 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 511 12 3 7 3.8 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)CCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44447137 154153 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 483 12 3 7 3.2 CCCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL398548 154153 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 483 12 3 7 3.2 CCCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44570537 178159 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 536 7 2 8 2.9 CN1C[C@@H](NC(=O)Nc2cccc(-c3nnnn3C)c2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
CHEMBL464902 178159 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 536 7 2 8 2.9 CN1C[C@@H](NC(=O)Nc2cccc(-c3nnnn3C)c2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
10050884 154652 14 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2008.11.002
CHEMBL399495 154652 14 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2008.11.002
44447143 94588 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 469 11 4 7 2.7 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CNCCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL252035 94588 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 469 11 4 7 2.7 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CNCCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
10050884 154652 14 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.087
CHEMBL399495 154652 14 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.087
44447144 168772 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 483 11 3 7 3.0 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL437396 168772 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 483 11 3 7 3.0 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
10050884 154652 14 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
CHEMBL399495 154652 14 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
44455658 167273 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 8 3 5 4.4 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nccn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL429323 167273 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 8 3 5 4.4 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nccn2C)c1 10.1016/j.bmcl.2007.11.067
11488078 79001 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113077 79001 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44593553 178367 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 489 6 2 6 3.9 Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1016/j.bmcl.2008.11.002
CHEMBL465272 178367 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 489 6 2 6 3.9 Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1016/j.bmcl.2008.11.002
44447139 94553 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 495 12 3 7 3.2 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC1CC1 10.1016/j.bmcl.2007.11.087
CHEMBL251838 94553 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 495 12 3 7 3.2 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC1CC1 10.1016/j.bmcl.2007.11.087
44447135 94676 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 455 10 3 7 2.5 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)CCCc1ccc(F)cc1 10.1016/j.bmcl.2007.11.087
CHEMBL252631 94676 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 455 10 3 7 2.5 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)CCCc1ccc(F)cc1 10.1016/j.bmcl.2007.11.087
44447361 94953 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 453 9 4 8 1.8 C[C@@H]([C@@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254503 94953 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 453 9 4 8 1.8 C[C@@H]([C@@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44447138 154817 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 481 11 3 7 3.0 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)C1CC1 10.1016/j.bmcl.2007.11.087
CHEMBL400378 154817 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 481 11 3 7 3.0 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)C1CC1 10.1016/j.bmcl.2007.11.087
44447382 166613 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 497 12 3 7 3.4 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL428062 166613 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 497 12 3 7 3.4 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
10050884 154652 14 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3/CCR2 chimeric receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3/CCR2 chimeric receptor in CHO cells
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.087
CHEMBL399495 154652 14 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3/CCR2 chimeric receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3/CCR2 chimeric receptor in CHO cells
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.087
44455841 155445 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 509 9 3 7 3.8 CC(C)[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL403838 155445 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 509 9 3 7 3.8 CC(C)[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11328714 78998 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113074 78998 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44593547 176866 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 538 10 2 8 3.3 CCN(CCCc1ccc(F)cc1)CC1OC(=O)N(C)CC1(C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2008.11.002
CHEMBL461445 176866 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 538 10 2 8 3.3 CCN(CCCc1ccc(F)cc1)CC1OC(=O)N(C)CC1(C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2008.11.002
44419331 82774 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 453 9 3 4 4.7 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL217987 82774 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 453 9 3 4 4.7 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
25032958 94548 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 481 10 4 8 2.4 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)[C@@H](C)[C@@H](O)c2ccccc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL251822 94548 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 481 10 4 8 2.4 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)[C@@H](C)[C@@H](O)c2ccccc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44447145 94977 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 511 13 3 7 3.8 CCCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cc(CC)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254676 94977 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 511 13 3 7 3.8 CCCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cc(CC)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44455744 95431 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 495 8 3 7 3.5 Cc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL257029 95431 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 495 8 3 7 3.5 Cc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455817 155178 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 538 9 3 8 3.6 CNC(=O)O[C@H](C[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)N1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
CHEMBL402331 155178 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 538 9 3 8 3.6 CNC(=O)O[C@H](C[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)N1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
44455788 155618 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 536 10 2 7 4.3 CCc1cc(NC(=O)N[C@H](C)C[C@@H](N(C)C)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL404585 155618 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 536 10 2 7 4.3 CCc1cc(NC(=O)N[C@H](C)C[C@@H](N(C)C)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11329244 71116 11 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]eotaxin binding to human eosinophilsInhibition of [125I]eotaxin binding to human eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
CHEMBL195433 71116 11 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]eotaxin binding to human eosinophilsInhibition of [125I]eotaxin binding to human eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
11272103 124375 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]eotaxin binding to human eosinophilsInhibition of [125I]eotaxin binding to human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL363840 124375 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]eotaxin binding to human eosinophilsInhibition of [125I]eotaxin binding to human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
6918497 113430 2 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(03)00748-0
CHEMBL277930 113430 2 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(03)00748-0
CHEMBL331897 113430 2 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(03)00748-0
6918497 113430 2 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(01)00176-7
CHEMBL277930 113430 2 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(01)00176-7
CHEMBL331897 113430 2 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(01)00176-7
6918497 113430 2 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against I-Eotaxin binding to human CCR3 receptorsInhibitory activity against I-Eotaxin binding to human CCR3 receptors
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL277930 113430 2 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against I-Eotaxin binding to human CCR3 receptorsInhibitory activity against I-Eotaxin binding to human CCR3 receptors
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL331897 113430 2 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against I-Eotaxin binding to human CCR3 receptorsInhibitory activity against I-Eotaxin binding to human CCR3 receptors
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
11236950 94764 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 479 9 2 6 4.3 CN(CCCc1ccc(F)cc1)C[C@@H]1CCCC[C@H]1NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL253210 94764 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 479 9 2 6 4.3 CN(CCCc1ccc(F)cc1)C[C@@H]1CCCC[C@H]1NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44447146 94978 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 509 12 3 7 3.5 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)C2CC2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254677 94978 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 509 12 3 7 3.5 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)C2CC2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44447147 95005 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 523 13 3 7 3.8 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)CC2CC2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254881 95005 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 523 13 3 7 3.8 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)CC2CC2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44445886 94219 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 544 7 3 6 3.9 CNC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL249857 94219 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 544 7 3 6 3.9 CNC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
44455844 97416 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 509 10 3 7 4.0 CCC[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL269933 97416 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 509 10 3 7 4.0 CCC[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455791 155619 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 522 9 3 7 3.3 CC(=O)N[C@H](C[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)N1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
CHEMBL404586 155619 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 522 9 3 7 3.3 CC(=O)N[C@H](C[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)N1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
44289927 168327 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL43423 168327 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
11698698 123240 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 481 8 2 6 4.2 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3cccc(Cl)c3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL361369 123240 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 481 8 2 6 4.2 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3cccc(Cl)c3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44289927 168327 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL43423 168327 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
44390955 123690 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 493 8 2 6 4.3 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CCC2(C)C)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL362179 123690 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 493 8 2 6 4.3 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CCC2(C)C)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44419344 141773 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 495 11 2 4 5.9 CCCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL386073 141773 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 495 11 2 4 5.9 CCCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
11272103 124375 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
CHEMBL363840 124375 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
44445865 154854 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 544 7 3 6 3.9 CNC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL400589 154854 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 544 7 3 6 3.9 CNC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
44455461 155622 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 551 10 3 7 4.2 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)C(=O)O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL404618 155622 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 551 10 3 7 4.2 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)C(=O)O)c1 10.1016/j.bmcl.2007.11.067
44390838 128510 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL366710 128510 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
11398022 98631 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 10.1021/jm049530m
CHEMBL277131 98631 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 10.1021/jm049530m
11272103 124375 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL363840 124375 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
11397114 133469 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2cn[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL3706810 133469 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2cn[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
10459751 100173 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 533 9 2 10 2.7 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.01.059
CHEMBL288009 100173 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 533 9 2 10 2.7 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.01.059
44289701 101106 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 508 9 3 7 2.8 CNC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.01.059
CHEMBL295081 101106 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 508 9 3 7 2.8 CNC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.01.059
44455793 95227 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 483 9 3 5 4.4 CC(=O)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL256068 95227 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 483 9 3 5 4.4 CC(=O)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
44455625 97590 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 565 9 3 7 6.2 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nccs2)cc(-c2nccs2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL270806 97590 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 565 9 3 7 6.2 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nccs2)cc(-c2nccs2)c1 10.1016/j.bmcl.2007.11.067
11227406 94345 2 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of [125I]eotaxin binding to human eosinophilsInhibition of [125I]eotaxin binding to human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL250689 94345 2 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of [125I]eotaxin binding to human eosinophilsInhibition of [125I]eotaxin binding to human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
44419295 83215 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 497 11 3 5 4.4 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCO)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL218568 83215 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 497 11 3 5 4.4 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCO)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
44419298 138139 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 509 11 2 5 5.0 CC(=O)CN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL376737 138139 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 509 11 2 5 5.0 CC(=O)CN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
11329244 71116 11 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL195433 71116 11 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445863 94455 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 559 9 2 7 3.7 COCC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL251275 94455 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 559 9 2 7 3.7 COCC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
44445872 94513 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 533 9 2 6 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CCF)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251622 94513 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 533 9 2 6 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CCF)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445868 166975 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 567 9 2 7 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(Cc3ccco3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL428761 166975 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 567 9 2 7 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(Cc3ccco3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
11329244 71116 11 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
CHEMBL195433 71116 11 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
11156406 125171 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL364508 125171 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44290100 178621 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 481 9 3 7 3.0 Cn1nnnc1-c1cc(CO)cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL46747 178621 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 481 9 3 7 3.0 Cn1nnnc1-c1cc(CO)cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
44419345 83154 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 493 11 2 4 5.6 C=CCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL218262 83154 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 493 11 2 4 5.6 C=CCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
11272103 124375 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.087
CHEMBL363840 124375 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.087
44445842 155577 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 488 7 2 6 4.3 CC(=O)c1sc(NC(=O)N[C@@H]2COCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL404416 155577 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 488 7 2 6 4.3 CC(=O)c1sc(NC(=O)N[C@@H]2COCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455686 95492 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 523 9 3 7 4.3 CC(C)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL257293 95492 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 523 9 3 7 4.3 CC(C)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455871 97546 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 495 9 3 7 3.6 CC[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL270583 97546 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 495 9 3 7 3.6 CC[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11272103 124375 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL363840 124375 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
44455511 155027 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 9 2 6 4.0 CCc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL401545 155027 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 9 2 6 4.0 CCc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44295462 188409 0 None - 0 Human 9.0 pIC50 = 9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 519 12 3 7 4.3 CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50194 188409 0 None - 0 Human 9.0 pIC50 = 9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 519 12 3 7 4.3 CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/s0960-894x(02)00206-8
44295536 188435 0 None - 0 Human 9.0 pIC50 = 9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 479 12 3 4 5.3 CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50233 188435 0 None - 0 Human 9.0 pIC50 = 9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 479 12 3 4 5.3 CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
9892753 16500 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 516 8 3 4 5.5 CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm049530m
CHEMBL123611 16500 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 516 8 3 4 5.5 CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm049530m
11213416 133471 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2nc[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL3706812 133471 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2nc[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11169258 140897 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 587 8 2 10 3.8 Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1021/jm049530m
CHEMBL382108 140897 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 587 8 2 10 3.8 Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1021/jm049530m
11966688 12372 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 518 7 2 4 6.0 CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2C[N+]2(C)CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 10.1021/jm0201767
CHEMBL1185532 12372 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 518 7 2 4 6.0 CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2C[N+]2(C)CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 10.1021/jm0201767
CHEMBL419599 12372 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 518 7 2 4 6.0 CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2C[N+]2(C)CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 10.1021/jm0201767
9892753 16500 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 516 8 3 4 5.5 CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL123611 16500 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 516 8 3 4 5.5 CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
11730796 116828 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 499 7 3 4 5.2 CNC(=O)c1cccc(NC(=O)Nc2cccc(C#N)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL337962 116828 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 499 7 3 4 5.2 CNC(=O)c1cccc(NC(=O)Nc2cccc(C#N)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
44570617 178376 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 531 7 2 7 4.1 CC(=O)c1sc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2008.11.002
CHEMBL465291 178376 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 531 7 2 7 4.1 CC(=O)c1sc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2008.11.002
44445885 169008 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 558 8 3 6 4.3 CCNC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL439253 169008 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 558 8 3 6 4.3 CCNC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
44455483 97829 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 537 10 3 7 3.8 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)(C)C(=O)O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL272068 97829 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 537 10 3 7 3.8 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)(C)C(=O)O)c1 10.1016/j.bmcl.2007.11.067
44455458 167457 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 533 9 3 7 5.3 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2ccon2)cc(-c2ccon2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL429846 167457 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 533 9 3 7 5.3 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2ccon2)cc(-c2ccon2)c1 10.1016/j.bmcl.2007.11.067
44400941 68864 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 426 6 3 3 3.9 O=C(NC1C=CC=CN1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL192240 68864 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 426 6 3 3 3.9 O=C(NC1C=CC=CN1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11409583 69782 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 507 8 2 4 5.9 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1021/jm049530m
CHEMBL193575 69782 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 507 8 2 4 5.9 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1021/jm049530m
44445901 160207 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 501 7 2 6 4.2 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2008.11.002
CHEMBL410959 160207 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 501 7 2 6 4.2 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2008.11.002
44447375 94770 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 527 12 4 8 2.8 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)[C@@H](O)Cc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL253244 94770 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 527 12 4 8 2.8 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)[C@@H](O)Cc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44445854 94083 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 522 7 2 7 3.3 CC(=O)c1sc(NC(=O)N[C@@H]2CS(=O)(=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249057 94083 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 522 7 2 7 3.3 CC(=O)c1sc(NC(=O)N[C@@H]2CS(=O)(=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445891 94420 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 533 9 2 6 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CCF)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251044 94420 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 533 9 2 6 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CCF)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445915 155429 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 599 8 2 7 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C3CCOCC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL403742 155429 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 599 8 2 7 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C3CCOCC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445888 155659 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 526 8 2 7 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC#N)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL404857 155659 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 526 8 2 7 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC#N)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445901 160207 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 501 7 2 6 4.2 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL410959 160207 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 501 7 2 6 4.2 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455818 95441 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 523 10 3 7 4.2 CC(C)C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL257073 95441 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 523 10 3 7 4.2 CC(C)C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455510 95590 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 8 2 6 4.2 Cc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL257737 95590 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 8 2 6 4.2 Cc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455790 95722 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 480 8 3 7 3.2 C[C@H](C[C@@H](N)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL258322 95722 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 480 8 3 7 3.2 C[C@H](C[C@@H](N)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44289926 177559 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 453 9 2 4 4.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL46404 177559 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 453 9 2 4 4.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
44390883 64074 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.8 CCc1cc(NC(=O)N[C@@H]2CCCN(CCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL180746 64074 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.8 CCc1cc(NC(=O)N[C@@H]2CCCN(CCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
11167549 79000 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 480 6 2 4 6.1 O=C(Nc1ccc2ncsc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113076 79000 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 480 6 2 4 6.1 O=C(Nc1ccc2ncsc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44290018 166704 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 465 9 2 6 4.0 CCn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL42826 166704 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 465 9 2 6 4.0 CCn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
44289741 170730 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 519 8 2 6 4.5 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2004.01.059
CHEMBL44522 170730 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 519 8 2 6 4.5 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2004.01.059
44289926 177559 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 453 9 2 4 4.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2004.01.059
CHEMBL46404 177559 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 453 9 2 4 4.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2004.01.059
44419296 141450 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 511 12 3 5 4.8 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCCO)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL384199 141450 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 511 12 3 5 4.8 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCCO)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
44445884 94217 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 559 9 2 7 3.7 COCC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL249855 94217 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 559 9 2 7 3.7 COCC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
44445867 94292 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 526 8 2 7 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CC#N)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL250437 94292 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 526 8 2 7 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CC#N)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
16747712 154853 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(C)=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL400588 154853 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(C)=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445870 167264 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 543 9 2 7 4.1 CC(=O)CN1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL429303 167264 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 543 9 2 7 4.1 CC(=O)CN1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
44455539 166982 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 465 8 2 6 3.9 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL428775 166982 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 465 8 2 6 3.9 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
10096657 64854 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 479 8 2 6 3.9 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2C)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL182086 64854 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 479 8 2 6 3.9 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2C)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
11306550 79003 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 497 6 3 3 6.0 O=C(Nc1ccc2[nH]nc(Cl)c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113079 79003 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 497 6 3 3 6.0 O=C(Nc1ccc2[nH]nc(Cl)c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44419328 83308 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 411 8 3 3 4.5 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
CHEMBL219048 83308 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 411 8 3 3 4.5 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
44445895 94449 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 584 8 2 7 4.7 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C3CCN(C)CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251220 94449 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 584 8 2 7 4.7 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C3CCN(C)CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455482 97828 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 533 9 3 9 3.2 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2ccnn2)cc(-n2ccnn2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL272067 97828 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 533 9 3 9 3.2 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2ccnn2)cc(-n2ccnn2)c1 10.1016/j.bmcl.2007.11.067
11363005 60506 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL175634 60506 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11442162 70668 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 444 6 2 4 5.2 Cc1csc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1021/jm049530m
CHEMBL195044 70668 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 444 6 2 4 5.2 Cc1csc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1021/jm049530m
11454941 71142 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cc1nnnn1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL195555 71142 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cc1nnnn1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
44445864 94482 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 558 8 3 6 4.3 CCNC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL251446 94482 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 558 8 3 6 4.3 CCNC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
44445916 155430 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 599 8 2 7 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C3CCOCC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL403743 155430 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 599 8 2 7 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C3CCOCC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455820 95442 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 551 11 3 7 4.9 CCC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL257074 95442 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 551 11 3 7 4.9 CCC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 10.1016/j.bmcl.2007.11.067
44455869 97545 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 507 9 2 7 4.1 CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL270582 97545 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 507 9 2 7 4.1 CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44289715 170235 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 465 8 2 6 3.8 Cc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL444568 170235 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 465 8 2 6 3.8 Cc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11340670 127234 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 483 7 2 3 5.8 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F 10.1021/jm049530m
CHEMBL365820 127234 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 483 7 2 3 5.8 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F 10.1021/jm049530m
44289715 170235 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 465 8 2 6 3.8 Cc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.01.059
CHEMBL444568 170235 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 465 8 2 6 3.8 Cc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.01.059
44445887 94220 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 572 9 2 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)CN(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249858 94220 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 572 9 2 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)CN(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445866 154963 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 572 9 2 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)CN(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL401159 154963 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 572 9 2 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)CN(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455847 155446 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 501 9 2 6 4.7 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL403839 155446 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 501 9 2 6 4.7 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
10322255 62527 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL178230 62527 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44390945 62949 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 507 9 2 6 4.5 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2C(C)C)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL178503 62949 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 507 9 2 6 4.5 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2C(C)C)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
11154845 60717 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 6 2 2 5.8 Cc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL176077 60717 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 6 2 2 5.8 Cc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11454015 133472 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2cc[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL3706813 133472 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2cc[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
16126667 83066 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 425 8 2 3 4.9 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2C)c1 10.1016/j.bmcl.2006.08.012
CHEMBL218174 83066 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 425 8 2 3 4.9 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2C)c1 10.1016/j.bmcl.2006.08.012
44445839 155520 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 488 7 2 6 4.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCO[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL404213 155520 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 488 7 2 6 4.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCO[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455846 97460 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 515 9 2 6 5.1 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL270147 97460 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 515 9 2 6 5.1 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
44455765 155360 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 543 8 2 6 4.6 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(Br)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL403331 155360 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 543 8 2 6 4.6 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(Br)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11751629 79004 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 464 6 3 3 5.4 O=C(Nc1ccc2c(c1)CCN2)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113080 79004 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 464 6 3 3 5.4 O=C(Nc1ccc2c(c1)CCN2)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
10458976 95011 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 509 9 3 7 3.4 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254930 95011 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 509 9 3 7 3.4 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44445873 154964 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 572 9 2 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CC(=O)N(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL401160 154964 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 572 9 2 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CC(=O)N(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455766 95685 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 8 2 6 4.3 C[C@H](C[C@@H](C)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL258156 95685 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 8 2 6 4.3 C[C@H](C[C@@H](C)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455745 155301 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 559 8 3 7 4.0 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(Br)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL402983 155301 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 559 8 3 7 4.0 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(Br)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455711 168733 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 509 9 3 7 3.8 CCc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL437031 168733 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 509 9 3 7 3.8 CCc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44390938 62955 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 483 8 2 6 3.8 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3F)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL178506 62955 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 483 8 2 6 3.8 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3F)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
11351206 69423 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 441 6 2 2 5.6 O=C(Nc1ccccc1F)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL193330 69423 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 441 6 2 2 5.6 O=C(Nc1ccccc1F)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11477384 133470 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 490 6 3 2 6.6 Cc1[nH]c2cc(NC(=O)N[C@@H]3CCCC[C@H]3CN3CCC[C@@H](Cc4ccc(F)cc4)C3)ccc2c1C 10.1021/jm049530m
CHEMBL3706811 133470 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 490 6 3 2 6.6 Cc1[nH]c2cc(NC(=O)N[C@@H]3CCCC[C@H]3CN3CCC[C@@H](Cc4ccc(F)cc4)C3)ccc2c1C 10.1021/jm049530m
44419301 84082 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 491 10 2 4 5.1 C#CCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL220765 84082 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 491 10 2 4 5.1 C#CCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
11953409 94216 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249854 94216 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445845 94242 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 487 7 3 6 3.8 CC(=O)c1sc(NC(=O)N[C@@H]2CCNC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL250056 94242 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 487 7 3 6 3.8 CC(=O)c1sc(NC(=O)N[C@@H]2CCNC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44390837 63548 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 479 9 2 6 4.0 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL180042 63548 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 479 9 2 6 4.0 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
11419003 70908 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 430 6 2 4 4.9 O=C(Nc1nccs1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL195129 70908 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 430 6 2 4 4.9 O=C(Nc1nccs1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44401328 71096 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL195348 71096 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 10.1021/jm049530m
11373714 127174 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 427 6 2 4 4.2 Cn1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1021/jm049530m
CHEMBL365732 127174 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 427 6 2 4 4.2 Cn1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1021/jm049530m
9680 1898 6 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 450 7 3 4 2.8 O=C(NCc1ccc(cc1)C(=O)N)NC[C@H]1OCCN(C1)Cc1ccc(c(c1)Cl)Cl 10.1021/jm300682j
9825034 1898 6 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 450 7 3 4 2.8 O=C(NCc1ccc(cc1)C(=O)N)NC[C@H]1OCCN(C1)Cc1ccc(c(c1)Cl)Cl 10.1021/jm300682j
CHEMBL2178574 1898 6 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 450 7 3 4 2.8 O=C(NCc1ccc(cc1)C(=O)N)NC[C@H]1OCCN(C1)Cc1ccc(c(c1)Cl)Cl 10.1021/jm300682j
22393282 101206 0 None - 1 Human 8.0 pIC50 = 8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL295832 101206 0 None - 1 Human 8.0 pIC50 = 8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
22393282 101206 0 None - 1 Human 8.0 pIC50 = 8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
CHEMBL295832 101206 0 None - 1 Human 8.0 pIC50 = 8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
11385178 124807 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 441 6 2 2 5.6 O=C(Nc1cccc(F)c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL364263 124807 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 441 6 2 2 5.6 O=C(Nc1cccc(F)c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
22393282 101206 0 None - 1 Human 8.0 pIC50 = 8 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL295832 101206 0 None - 1 Human 8.0 pIC50 = 8 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.01.059
44440398 93333 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 584 8 0 5 6.3 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(C2CCCCC2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL245310 93333 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 584 8 0 5 6.3 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(C2CCCCC2)n1C 10.1016/j.bmcl.2007.05.035
44440420 93532 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 608 9 0 6 5.8 COc1ccc(-n2c(=O)c(CN(CCc3ccc(Cl)cc3)C3CCN(C(=O)c4c(F)cccc4F)CC3)c(C)n2C)cc1 10.1016/j.bmcl.2007.05.035
CHEMBL246347 93532 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 608 9 0 6 5.8 COc1ccc(-n2c(=O)c(CN(CCc3ccc(Cl)cc3)C3CCN(C(=O)c4c(F)cccc4F)CC3)c(C)n2C)cc1 10.1016/j.bmcl.2007.05.035
44440424 149260 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 621 9 0 6 5.8 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(N(C)C)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL394443 149260 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 621 9 0 6 5.8 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(N(C)C)cc2)n1C 10.1016/j.bmcl.2007.05.035
44440426 149263 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 613 8 0 6 5.8 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2cnccc2Cl)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL394444 149263 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 613 8 0 6 5.8 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2cnccc2Cl)n1C 10.1016/j.bmcl.2007.05.035
44440411 150090 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2cccc(F)c2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL395090 150090 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2cccc(F)c2)n1C 10.1016/j.bmcl.2007.05.035
44440414 151023 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 594 8 1 6 5.5 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(O)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL395851 151023 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 594 8 1 6 5.5 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(O)cc2)n1C 10.1016/j.bmcl.2007.05.035
44440417 151026 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 623 9 0 7 5.7 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc([N+](=O)[O-])cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL395852 151026 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 623 9 0 7 5.7 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc([N+](=O)[O-])cc2)n1C 10.1016/j.bmcl.2007.05.035
44295264 187475 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 435 8 2 3 5.6 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(-c2ccco2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL49404 187475 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 435 8 2 3 5.6 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(-c2ccco2)c1 10.1016/s0960-894x(02)00206-8
44295664 188695 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 435 10 2 3 5.5 CCC[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50423 188695 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 435 10 2 3 5.5 CCC[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
44295405 189081 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 435 8 3 3 4.7 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(-c2ncc[nH]2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50988 189081 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 435 8 3 3 4.7 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(-c2ncc[nH]2)c1 10.1016/s0960-894x(02)00206-8
22393436 189310 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 375 7 2 2 4.1 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NC1CCCCC1 10.1016/s0960-894x(02)00206-8
CHEMBL51229 189310 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 375 7 2 2 4.1 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NC1CCCCC1 10.1016/s0960-894x(02)00206-8
44295567 190653 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 465 10 3 4 4.7 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@H](O)C(C)C)c1 10.1016/s0960-894x(02)00206-8
CHEMBL51815 190653 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 465 10 3 4 4.7 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@H](O)C(C)C)c1 10.1016/s0960-894x(02)00206-8
9979012 79802 0 None - 0 Human 6.0 pIC50 = 6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 411 7 1 5 4.4 O=C(CSc1nc2ccccc2s1)NCC1CCCN(Cc2ccccc2)C1 10.1016/s0960-894x(01)00176-7
CHEMBL21199 79802 0 None - 0 Human 6.0 pIC50 = 6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 411 7 1 5 4.4 O=C(CSc1nc2ccccc2s1)NCC1CCCN(Cc2ccccc2)C1 10.1016/s0960-894x(01)00176-7
44273640 98928 0 None - 0 Human 6.0 pIC50 = 6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 417 7 1 5 4.8 O=C(CSc1nc2ccccc2s1)NCC1CCCN(CC2CCCCC2)C1 10.1016/s0960-894x(01)00176-7
CHEMBL279450 98928 0 None - 0 Human 6.0 pIC50 = 6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 417 7 1 5 4.8 O=C(CSc1nc2ccccc2s1)NCC1CCCN(CC2CCCCC2)C1 10.1016/s0960-894x(01)00176-7
57401421 67865 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 486 6 1 3 5.1 O=C(NCCCN1CCC(c2ccc(F)cc2)CC1)C1=Cc2cc(Br)ccc2OCC1 10.1016/j.bmcl.2011.09.013
CHEMBL1910161 67865 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 486 6 1 3 5.1 O=C(NCCCN1CCC(c2ccc(F)cc2)CC1)C1=Cc2cc(Br)ccc2OCC1 10.1016/j.bmcl.2011.09.013
44440435 93439 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 563 8 0 6 4.6 Cc1c(CN(CCc2ccccn2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL245956 93439 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 563 8 0 6 4.6 Cc1c(CN(CCc2ccccn2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
44295529 187300 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 368 8 1 2 4.3 O=C(NCCCCN1CCC(Cc2ccccc2)CC1)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL49296 187300 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 368 8 1 2 4.3 O=C(NCCCCN1CCC(Cc2ccccc2)CC1)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
44349617 118118 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 336 4 0 2 4.0 Fc1ccc(CCCN2CCC3C(C2)c2cccc4c2N3CC4)cc1 10.1021/jm0201767
CHEMBL340770 118118 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 336 4 0 2 4.0 Fc1ccc(CCCN2CCC3C(C2)c2cccc4c2N3CC4)cc1 10.1021/jm0201767
5481702 205823 1 None - 0 Human 5.0 pIC50 = 5 Binding
Compound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR3 receptorCompound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR3 receptor
ChEMBL 556 8 0 4 5.3 CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1 10.1016/s0960-894x(00)00639-9
CHEMBL83338 205823 1 None - 0 Human 5.0 pIC50 = 5 Binding
Compound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR3 receptorCompound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR3 receptor
ChEMBL 556 8 0 4 5.3 CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1 10.1016/s0960-894x(00)00639-9
44442590 93772 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells
ChEMBL 606 11 6 5 3.8 Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)C(=O)NC(C)(C)C)c(C)c1 10.1016/j.bmcl.2007.07.028
CHEMBL247455 93772 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells
ChEMBL 606 11 6 5 3.8 Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)C(=O)NC(C)(C)C)c(C)c1 10.1016/j.bmcl.2007.07.028
44295435 189653 0 None - 0 Human 5.0 pIC50 = 5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 415 6 1 4 2.7 O=S(=O)(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL51512 189653 0 None - 0 Human 5.0 pIC50 = 5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 415 6 1 4 2.7 O=S(=O)(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
44346194 15548 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 501 9 2 5 5.4 COc1cc(NC(=O)N[C@H](C)CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
CHEMBL121905 15548 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 501 9 2 5 5.4 COc1cc(NC(=O)N[C@H](C)CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
11006582 11456 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 483 6 2 4 5.5 C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL1180359 11456 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 483 6 2 4 5.5 C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL123616 11456 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 483 6 2 4 5.5 C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccccc2)CC1 10.1021/jm0201767
11059789 16772 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 472 7 3 4 5.3 N#Cc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL124438 16772 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 472 7 3 4 5.3 N#Cc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
10983981 16848 1 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 505 8 2 5 5.7 COC(=O)c1cccc(NC(=O)Nc2cccc(OC)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL124821 16848 1 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 505 8 2 5 5.7 COC(=O)c1cccc(NC(=O)Nc2cccc(OC)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
10895831 118413 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 461 8 2 3 6.0 COc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL341074 118413 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 461 8 2 3 6.0 COc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
44295486 101499 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 502 5 2 3 4.0 O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)Nc1cccc(I)c1 10.1016/s0960-894x(02)00206-8
CHEMBL297945 101499 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 502 5 2 3 4.0 O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)Nc1cccc(I)c1 10.1016/s0960-894x(02)00206-8
20576924 189239 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 364 5 0 3 4.0 O=C(CCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL51163 189239 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 364 5 0 3 4.0 O=C(CCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
45270199 196418 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Inhibition of mouse CCR3Inhibition of mouse CCR3
ChEMBL 516 5 1 4 4.2 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1cc[n+]([O-])cc1C(=O)N1CCCCC1 10.1016/j.bmc.2009.06.066
CHEMBL562897 196418 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Inhibition of mouse CCR3Inhibition of mouse CCR3
ChEMBL 516 5 1 4 4.2 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1cc[n+]([O-])cc1C(=O)N1CCCCC1 10.1016/j.bmc.2009.06.066
44295408 188799 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 381 6 1 3 3.7 O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)C1CCCCC1 10.1016/s0960-894x(02)00206-8
CHEMBL50591 188799 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 381 6 1 3 3.7 O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)C1CCCCC1 10.1016/s0960-894x(02)00206-8
11101888 113306 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 421 5 2 2 6.0 O=C(Nc1cc(F)ccc1F)Nc1ccccc1CN1CCC(c2ccccc2)CC1 10.1021/jm0201767
CHEMBL331530 113306 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 421 5 2 2 6.0 O=C(Nc1cc(F)ccc1F)Nc1ccccc1CN1CCC(c2ccccc2)CC1 10.1021/jm0201767
10983308 17977 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 454 7 3 4 5.1 N#Cc1cccc(NC(=O)Nc2cc(CO)ccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL126174 17977 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 454 7 3 4 5.1 N#Cc1cccc(NC(=O)Nc2cc(CO)ccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
57392726 67871 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 490 8 0 5 4.2 COc1ccc(OC)c(S(=O)(=O)N2CCC(CN3CCC(Cc4ccc(F)cc4)CC3)CC2)c1 10.1016/j.bmcl.2011.09.013
CHEMBL1910167 67871 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 490 8 0 5 4.2 COc1ccc(OC)c(S(=O)(=O)N2CCC(CN3CCC(Cc4ccc(F)cc4)CC3)CC2)c1 10.1016/j.bmcl.2011.09.013
44346153 15503 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 519 8 3 5 4.1 C[C@H](O)[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 10.1016/s0960-894x(03)00748-0
CHEMBL121637 15503 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 519 8 3 5 4.1 C[C@H](O)[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 10.1016/s0960-894x(03)00748-0
44346154 168661 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorCompound was tested for its ability to inhibit C-C chemokine receptor type 3 receptor
ChEMBL 489 7 2 4 4.7 C[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 10.1016/s0960-894x(03)00748-0
CHEMBL436363 168661 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorCompound was tested for its ability to inhibit C-C chemokine receptor type 3 receptor
ChEMBL 489 7 2 4 4.7 C[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 10.1016/s0960-894x(03)00748-0
44440437 146463 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 600 9 0 8 4.9 Cc1ccnc(C)c1C(=O)N1CCC(N(CCc2ccc([N+](=O)[O-])cc2)Cc2c(C)n(C)n(-c3ccc(F)cc3)c2=O)CC1 10.1016/j.bmcl.2007.05.035
CHEMBL392218 146463 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 600 9 0 8 4.9 Cc1ccnc(C)c1C(=O)N1CCC(N(CCc2ccc([N+](=O)[O-])cc2)Cc2c(C)n(C)n(-c3ccc(F)cc3)c2=O)CC1 10.1016/j.bmcl.2007.05.035
23657036 146464 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 572 9 0 8 4.3 Cc1c(CN(CCc2ccc([N+](=O)[O-])cc2)C2CCN(C(=O)c3ccccn3)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL392219 146464 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 572 9 0 8 4.3 Cc1c(CN(CCc2ccc([N+](=O)[O-])cc2)C2CCN(C(=O)c3ccccn3)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
44390848 122390 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3cccc(F)c3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL360062 122390 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3cccc(F)c3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
9868532 60487 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
CHEMBL175502 60487 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
11396995 70302 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 459 6 2 2 5.7 O=C(Nc1ccc(F)c(F)c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL194384 70302 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 459 6 2 2 5.7 O=C(Nc1ccc(F)c(F)c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44387837 123832 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 448 6 2 3 5.3 N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
CHEMBL362465 123832 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 448 6 2 3 5.3 N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
44419303 141847 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 517 11 2 4 5.7 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(F)F)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL386493 141847 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 517 11 2 4 5.7 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(F)F)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
44390843 64179 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 477 9 2 7 3.5 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(OC)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL180860 64179 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 477 9 2 7 3.5 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(OC)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44295374 101591 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 404 9 2 3 4.8 N#Cc1cccc(NC(=O)NCCCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL298681 101591 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 404 9 2 3 4.8 N#Cc1cccc(NC(=O)NCCCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
44295352 188684 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 380 9 1 3 4.2 COc1cccc(C(=O)NCCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50400 188684 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 380 9 1 3 4.2 COc1cccc(C(=O)NCCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
44295372 189163 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 419 7 2 2 5.2 O=C(NCCCN1CCC(Cc2ccccc2)CC1)Nc1ccc(C(F)(F)F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL51113 189163 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 419 7 2 2 5.2 O=C(NCCCN1CCC(Cc2ccccc2)CC1)Nc1ccc(C(F)(F)F)cc1 10.1016/s0960-894x(02)00206-8
10623381 16902 0 None - 1 Human 4.9 pIC50 = 4.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 448 8 2 3 5.3 NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL125111 16902 0 None - 1 Human 4.9 pIC50 = 4.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 448 8 2 3 5.3 NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
44349204 17208 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 350 5 0 2 3.8 CC1C2=C(CC=CC2)C(=O)N1CC1CCN(CCc2ccccc2)CC1 10.1021/jm0201767
CHEMBL125643 17208 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 350 5 0 2 3.8 CC1C2=C(CC=CC2)C(=O)N1CC1CCN(CCc2ccccc2)CC1 10.1021/jm0201767
11037869 16723 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 459 7 2 3 6.1 CC(=O)c1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
CHEMBL124317 16723 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 459 7 2 3 6.1 CC(=O)c1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
11037869 16723 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 459 7 2 3 6.1 CC(=O)c1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL124317 16723 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 459 7 2 3 6.1 CC(=O)c1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
44419314 83301 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 376 7 3 3 4.1 N#Cc1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
CHEMBL218997 83301 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 376 7 3 3 4.1 N#Cc1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
44593553 178367 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 489 6 2 6 3.9 Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1016/j.bmcl.2008.11.002
CHEMBL465272 178367 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 489 6 2 6 3.9 Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1016/j.bmcl.2008.11.002
44390891 63974 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 7 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NC[C@H]2CCCN(CCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL180694 63974 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 7 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NC[C@H]2CCCN(CCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
44295544 188930 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 375 8 1 3 4.0 N#Cc1ccc(C(=O)NCCCCN2CCC(Cc3ccccc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL50801 188930 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 375 8 1 3 4.0 N#Cc1ccc(C(=O)NCCCCN2CCC(Cc3ccccc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
11826382 17272 1 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 443 8 2 3 5.5 COc1ccc(NC(=O)NCc2ccccc2CN2CCC(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
CHEMBL125695 17272 1 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 443 8 2 3 5.5 COc1ccc(NC(=O)NCc2ccccc2CN2CCC(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
44419305 82631 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 535 10 2 4 6.0 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(F)(F)F)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL217928 82631 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 535 10 2 4 6.0 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(F)(F)F)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
44390867 62579 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 451 7 2 6 3.4 CCc1cc(NC(=O)N[C@@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL178278 62579 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 451 7 2 6 3.4 CCc1cc(NC(=O)N[C@@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
11396851 60497 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
CHEMBL175559 60497 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
11247999 77970 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL2096763 77970 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
10972522 17130 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 456 7 2 3 5.8 N#Cc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL125549 17130 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 456 7 2 3 5.8 N#Cc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
11004663 117602 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 438 7 2 3 5.7 N#Cc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL340080 117602 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 438 7 2 3 5.7 N#Cc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
10917990 16494 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 491 7 2 5 5.7 COc1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 10.1021/jm0201767
CHEMBL123580 16494 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 491 7 2 5 5.7 COc1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 10.1021/jm0201767
11729258 16845 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 409 8 0 3 5.1 N#CC(CCCN1CCN(Cc2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL124808 16845 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 409 8 0 3 5.1 N#CC(CCCN1CCN(Cc2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
44419323 84135 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 390 8 3 3 4.5 N#Cc1cccc(NC(=O)NCCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
CHEMBL220800 84135 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 390 8 3 3 4.5 N#Cc1cccc(NC(=O)NCCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
11609863 16846 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 343 6 1 2 4.6 OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccccc2)CC1 10.1021/jm0201767
CHEMBL124813 16846 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 343 6 1 2 4.6 OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccccc2)CC1 10.1021/jm0201767
44390851 123859 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NC[C@H]2CCCN(CCCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL362613 123859 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NC[C@H]2CCCN(CCCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
44442599 93649 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells
ChEMBL 585 9 5 5 3.3 Cc1cc(Br)ccc1CNC[C@H](NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1N)C(=O)NC(C)(C)C 10.1016/j.bmcl.2007.07.028
CHEMBL246804 93649 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells
ChEMBL 585 9 5 5 3.3 Cc1cc(Br)ccc1CNC[C@H](NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1N)C(=O)NC(C)(C)C 10.1016/j.bmcl.2007.07.028
44295145 191597 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 502 5 2 3 4.0 O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)Nc1ccc(I)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL51953 191597 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 502 5 2 3 4.0 O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)Nc1ccc(I)cc1 10.1016/s0960-894x(02)00206-8
11059385 158397 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 448 8 1 2 5.6 O=C(Cc1ccc(F)cc1)Nc1ccccc1CCN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL409001 158397 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 448 8 1 2 5.6 O=C(Cc1ccc(F)cc1)Nc1ccccc1CCN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
44440419 93531 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 603 8 0 6 5.6 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(C#N)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL246346 93531 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 603 8 0 6 5.6 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(C#N)cc2)n1C 10.1016/j.bmcl.2007.05.035
44440393 93916 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 586 10 0 5 6.8 Cc1c(CN(CCCCc2ccccc2)C2CCN(C(=O)c3cccc4ccccc34)CC2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL248178 93916 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 586 10 0 5 6.8 Cc1c(CN(CCCCc2ccccc2)C2CCN(C(=O)c3cccc4ccccc34)CC2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2007.05.035
44445851 154581 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 573 7 2 7 5.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)C[C@@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL399133 154581 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 573 7 2 7 5.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)C[C@@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44295354 189161 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 394 8 2 3 4.2 CN(C)c1ccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL51110 189161 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 394 8 2 3 4.2 CN(C)c1ccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
23509664 194946 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 421 6 1 3 4.9 COc1cccc(NC(=O)N2CCC(CN3CCC(Cc4ccccc4)CC3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL54251 194946 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 421 6 1 3 4.9 COc1cccc(NC(=O)N2CCC(CN3CCC(Cc4ccccc4)CC3)CC2)c1 10.1016/s0960-894x(02)00206-8
9907041 167829 2 None - 0 Human 4.8 pIC50 = 4.8 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 363 7 2 5 2.2 CCOC(=O)[C@H](Cc1ccc(O)cc1)NS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(01)00248-7
CHEMBL430745 167829 2 None - 0 Human 4.8 pIC50 = 4.8 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 363 7 2 5 2.2 CCOC(=O)[C@H](Cc1ccc(O)cc1)NS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(01)00248-7
10974378 114297 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 664 12 3 4 7.4 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)NC1CCN(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL333063 114297 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 664 12 3 4 7.4 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)NC1CCN(Cc2ccccc2)CC1 10.1021/jm0201767
71458114 79616 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 4.9 CC(=O)c1cccc(NC(=O)NCCCN2CC3CCC2[C@@H](Cc2ccc(F)cc2)C3)c1 10.1016/j.bmcl.2004.01.059
CHEMBL2114958 79616 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 4.9 CC(=O)c1cccc(NC(=O)NCCCN2CC3CCC2[C@@H](Cc2ccc(F)cc2)C3)c1 10.1016/j.bmcl.2004.01.059
10983419 117461 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 461 7 3 3 5.6 O=C(Nc1ccccc1)Nc1cccc(C(=O)O)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL339884 117461 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 461 7 3 3 5.6 O=C(Nc1ccccc1)Nc1cccc(C(=O)O)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
44295480 189610 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 439 6 1 3 5.2 COc1cccc(NC(=O)N2CCCCC2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL51480 189610 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 439 6 1 3 5.2 COc1cccc(NC(=O)N2CCCCC2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
20613253 113342 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 446 7 1 2 6.4 Cc1ccc(C(=O)NC(CC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
CHEMBL331702 113342 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 446 7 1 2 6.4 Cc1ccc(C(=O)NC(CC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
44281525 109703 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 314 6 2 5 1.7 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccn1 10.1016/s0960-894x(01)00248-7
CHEMBL32282 109703 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 314 6 2 5 1.7 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccn1 10.1016/s0960-894x(01)00248-7
10928228 16795 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 435 6 2 2 6.1 O=C(Nc1cc(F)ccc1F)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL124583 16795 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 435 6 2 2 6.1 O=C(Nc1cc(F)ccc1F)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
10874167 170842 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 457 7 2 4 5.2 O=C(NCc1ccc2c(c1)OCO2)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL445379 170842 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 457 7 2 4 5.2 O=C(NCc1ccc2c(c1)OCO2)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
44281789 111350 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 454 8 1 5 4.8 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)OCc1ccccc1)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL32692 111350 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 454 8 1 5 4.8 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)OCc1ccccc1)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
11026634 113331 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 443 8 2 3 5.8 COc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL331634 113331 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 443 8 2 3 5.8 COc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
22022826 16449 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 472 7 1 2 6.5 Cc1ccc(C(=O)NC(CN2C3CCC2CC(Cc2ccc(Cl)c(Cl)c2)C3)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
CHEMBL123308 16449 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 472 7 1 2 6.5 Cc1ccc(C(=O)NC(CN2C3CCC2CC(Cc2ccc(Cl)c(Cl)c2)C3)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
44419322 84374 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 362 6 3 3 3.7 N#Cc1cccc(NC(=O)NCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
CHEMBL221901 84374 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 362 6 3 3 3.7 N#Cc1cccc(NC(=O)NCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
15907328 163363 34 None - 0 Human 4.7 pIC50 = 4.7 Binding
Evaluated for its inhibitory activity against human Chemokine receptor type 3 expressed in chinese hamster ovary cellsEvaluated for its inhibitory activity against human Chemokine receptor type 3 expressed in chinese hamster ovary cells
ChEMBL 301 3 1 2 3.8 OC1(c2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL419244 163363 34 None - 0 Human 4.7 pIC50 = 4.7 Binding
Evaluated for its inhibitory activity against human Chemokine receptor type 3 expressed in chinese hamster ovary cellsEvaluated for its inhibitory activity against human Chemokine receptor type 3 expressed in chinese hamster ovary cells
ChEMBL 301 3 1 2 3.8 OC1(c2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1 10.1021/jm0201767
44447374 94729 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 499 11 4 8 2.2 CCN(C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](C)[C@@H](O)Cc1ccc(F)cc1 10.1016/j.bmcl.2007.11.087
CHEMBL253034 94729 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 499 11 4 8 2.2 CCN(C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](C)[C@@H](O)Cc1ccc(F)cc1 10.1016/j.bmcl.2007.11.087
44289763 165051 0 None - 1 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 412 7 2 3 4.3 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccc(F)cc3F)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL42264 165051 0 None - 1 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 412 7 2 3 4.3 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccc(F)cc3F)C2)c1 10.1016/j.bmcl.2004.01.059
22143196 183987 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of CCR3 at 10 uMInhibition of CCR3 at 10 uM
ChEMBL 509 7 5 6 2.0 CSc1ccc(C(=O)NC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 10.1016/j.bmcl.2008.12.062
CHEMBL481790 183987 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of CCR3 at 10 uMInhibition of CCR3 at 10 uM
ChEMBL 509 7 5 6 2.0 CSc1ccc(C(=O)NC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 10.1016/j.bmcl.2008.12.062
209394 116632 13 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 297 6 1 3 2.6 CCOC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
CHEMBL33693 116632 13 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 297 6 1 3 2.6 CCOC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
11814253 116955 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 635 10 3 3 8.2 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cccc(C(F)(F)F)c1 10.1021/jm0201767
CHEMBL338624 116955 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 635 10 3 3 8.2 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cccc(C(F)(F)F)c1 10.1021/jm0201767
12000105 84242 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 453 10 2 3 5.7 CCCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL221067 84242 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 453 10 2 3 5.7 CCCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
11227406 94345 2 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm300682j
CHEMBL250689 94345 2 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm300682j
11272103 124375 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2008.11.002
CHEMBL363840 124375 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2008.11.002
44445876 94087 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 501 7 2 6 4.2 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249060 94087 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 501 7 2 6 4.2 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445856 94263 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 557 8 2 6 4.7 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL250262 94263 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 557 8 2 6 4.7 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
11227406 94345 2 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
CHEMBL250689 94345 2 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
44445892 94421 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 572 9 2 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC(=O)N(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251045 94421 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 572 9 2 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC(=O)N(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445840 94451 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 488 7 2 6 4.3 CC(=O)c1sc(NC(=O)N[C@@H]2CCOC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251232 94451 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 488 7 2 6 4.3 CC(=O)c1sc(NC(=O)N[C@@H]2CCOC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445894 154731 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 612 8 2 7 4.6 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C3CCN(C(C)=O)CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL399893 154731 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 612 8 2 7 4.6 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C3CCN(C(C)=O)CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
21362425 155003 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 584 8 2 7 4.7 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C3CCN(C)CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL401394 155003 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 584 8 2 7 4.7 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C3CCN(C)CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
11227406 94345 2 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL250689 94345 2 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
44455509 166426 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 493 9 2 6 4.4 CCc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL427728 166426 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 493 9 2 6 4.4 CCc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455560 169279 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 517 9 2 8 3.8 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2ccnn2)cc(-n2ccnn2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL441334 169279 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 517 9 2 8 3.8 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2ccnn2)cc(-n2ccnn2)c1 10.1016/j.bmcl.2007.11.067
11363006 70435 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 10.1021/jm049530m
CHEMBL194601 70435 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 10.1021/jm049530m
11227406 94345 2 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL250689 94345 2 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
44401123 136280 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 516 7 2 5 4.9 N#CC1=CC(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)CC=C1n1cccn1 10.1021/jm049530m
CHEMBL373347 136280 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 516 7 2 5 4.9 N#CC1=CC(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)CC=C1n1cccn1 10.1021/jm049530m
11017618 11470 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 501 6 2 4 5.7 C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL1180385 11470 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 501 6 2 4 5.7 C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL124689 11470 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 501 6 2 4 5.7 C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
11762511 16563 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 474 7 3 3 5.3 CNC(=O)c1cccc(NC(=O)Nc2ccccc2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL123837 16563 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 474 7 3 3 5.3 CNC(=O)c1cccc(NC(=O)Nc2ccccc2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
11134936 16745 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 504 8 3 4 5.3 CNC(=O)c1cccc(NC(=O)Nc2cccc(OC)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL124334 16745 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 504 8 3 4 5.3 CNC(=O)c1cccc(NC(=O)Nc2cccc(OC)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
11038430 16823 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 502 8 3 4 5.2 CC(=O)c1cccc(NC(=O)Nc2cccc(C(N)=O)c2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL124722 16823 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 502 8 3 4 5.2 CC(=O)c1cccc(NC(=O)Nc2cccc(C(N)=O)c2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
44570581 178416 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 536 10 2 8 3.1 CN1C[C@@H](NC(=O)Nc2cccc(-c3nnnn3C)c2)[C@H](CN(CCCc2ccc(F)cc2)C2CC2)OC1=O 10.1016/j.bmcl.2008.11.002
CHEMBL465942 178416 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 536 10 2 8 3.1 CN1C[C@@H](NC(=O)Nc2cccc(-c3nnnn3C)c2)[C@H](CN(CCCc2ccc(F)cc2)C2CC2)OC1=O 10.1016/j.bmcl.2008.11.002
44445847 94424 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 487 7 3 6 3.8 CC(=O)c1sc(NC(=O)N[C@@H]2CNCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251079 94424 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 487 7 3 6 3.8 CC(=O)c1sc(NC(=O)N[C@@H]2CNCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445878 154598 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 557 8 2 6 4.7 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL399150 154598 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 557 8 2 6 4.7 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445880 155236 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 543 8 2 6 4.5 CCC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL402707 155236 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 543 8 2 6 4.5 CCC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
21362416 94084 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 612 8 2 7 4.6 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C3CCN(C(C)=O)CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249058 94084 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 612 8 2 7 4.6 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C3CCN(C(C)=O)CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44390927 63000 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 493 9 2 6 4.3 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2CC)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL178671 63000 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 493 9 2 6 4.3 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2CC)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44390894 122360 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 479 9 2 6 4.0 CCc1cc(NC(=O)NC[C@H]2CCCN(CCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL360039 122360 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 479 9 2 6 4.0 CCc1cc(NC(=O)NC[C@H]2CCCN(CCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
11179351 124614 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 490 7 2 5 5.0 O=C(Nc1ccc(-n2cncn2)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL364068 124614 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 490 7 2 5 5.0 O=C(Nc1ccc(-n2cncn2)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44419300 84003 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 499 11 2 4 5.4 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCF)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL220713 84003 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 499 11 2 4 5.4 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCF)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
795 574 5 None - 1 Human 8.6 pIC50 = 8.6 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 10.1016/s0960-894x(03)00748-0
796 574 5 None - 1 Human 8.6 pIC50 = 8.6 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 10.1016/s0960-894x(03)00748-0
9913085 574 5 None - 1 Human 8.6 pIC50 = 8.6 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 10.1016/s0960-894x(03)00748-0
CHEMBL20921 574 5 None - 1 Human 8.6 pIC50 = 8.6 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 10.1016/s0960-894x(03)00748-0
795 574 5 None - 1 Human 8.6 pIC50 = 8.6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 10.1016/s0960-894x(01)00176-7
796 574 5 None - 1 Human 8.6 pIC50 = 8.6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 10.1016/s0960-894x(01)00176-7
9913085 574 5 None - 1 Human 8.6 pIC50 = 8.6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 10.1016/s0960-894x(01)00176-7
CHEMBL20921 574 5 None - 1 Human 8.6 pIC50 = 8.6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 10.1016/s0960-894x(01)00176-7
44445875 94085 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 531 9 3 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CCO)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249059 94085 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 531 9 3 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CCO)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445859 154786 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 545 7 2 7 4.3 COC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL400173 154786 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 545 7 2 7 4.3 COC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
44401561 124121 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL363373 124121 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 10.1021/jm049530m
11750808 126196 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 431 6 2 5 4.3 O=C(Nc1nncs1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL364977 126196 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 431 6 2 5 4.3 O=C(Nc1nncs1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44346210 167955 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorCompound was tested for its ability to inhibit C-C chemokine receptor type 3 receptor
ChEMBL 531 10 3 6 4.7 COc1cc(NC(=O)N[C@@H](CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)[C@H](C)O)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
CHEMBL431670 167955 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorCompound was tested for its ability to inhibit C-C chemokine receptor type 3 receptor
ChEMBL 531 10 3 6 4.7 COc1cc(NC(=O)N[C@@H](CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)[C@H](C)O)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
44455845 97459 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 537 10 3 7 4.5 CC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL270146 97459 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 537 10 3 7 4.5 CC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 10.1016/j.bmcl.2007.11.067
44289713 166108 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 527 9 2 6 5.2 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2ccccc2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL42599 166108 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 527 9 2 6 5.2 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2ccccc2)c1 10.1016/j.bmcl.2004.01.059
44419335 84141 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 465 10 2 3 5.7 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC2CC2)c1 10.1016/j.bmcl.2006.08.012
CHEMBL220819 84141 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 465 10 2 3 5.7 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC2CC2)c1 10.1016/j.bmcl.2006.08.012
44447140 94554 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 523 11 3 7 4.2 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)C1CCCCC1 10.1016/j.bmcl.2007.11.087
CHEMBL251839 94554 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 523 11 3 7 4.2 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)C1CCCCC1 10.1016/j.bmcl.2007.11.087
44447154 94692 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 559 13 3 7 4.6 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)Cc2ccccc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL252792 94692 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 559 13 3 7 4.6 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)Cc2ccccc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44447380 94890 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 483 11 3 7 3.2 CCN(C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](C)CCc1ccc(F)cc1 10.1016/j.bmcl.2007.11.087
CHEMBL254093 94890 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 483 11 3 7 3.2 CCN(C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](C)CCc1ccc(F)cc1 10.1016/j.bmcl.2007.11.087
44445907 94833 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 409 7 2 3 4.6 CC(=O)c1cccc(NC(=O)N/C=C/CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
CHEMBL253676 94833 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 409 7 2 3 4.6 CC(=O)c1cccc(NC(=O)N/C=C/CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
44445883 155237 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 555 8 2 6 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C3CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL402708 155237 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 555 8 2 6 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C3CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44290039 178802 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL46905 178802 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
11430170 123833 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 423 6 2 2 5.5 O=C(Nc1ccccc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL362466 123833 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 423 6 2 2 5.5 O=C(Nc1ccccc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11385766 132796 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL370082 132796 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
44290039 178802 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL46905 178802 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
44290039 178802 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL46905 178802 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
44445849 94452 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 573 7 2 7 5.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251243 94452 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 573 7 2 7 5.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445889 154866 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 567 9 2 7 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CN(Cc3ccco3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL400649 154866 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 567 9 2 7 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CN(Cc3ccco3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44289919 101153 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 493 9 2 7 3.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL295415 101153 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 493 9 2 7 3.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455683 155088 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 531 9 3 7 4.4 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL401879 155088 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 531 9 3 7 4.4 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
44455485 155498 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 507 9 2 6 5.0 CC(C)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL404122 155498 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 507 9 2 6 5.0 CC(C)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455484 167406 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 493 9 2 6 4.6 CC(C)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL429604 167406 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 493 9 2 6 4.6 CC(C)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44387842 131301 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 369 5 2 3 4.2 CC(=O)c1cccc(NC(=O)NN2CCCCC2Cc2ccc(F)cc2)c1 10.1021/jm049530m
CHEMBL368683 131301 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 369 5 2 3 4.2 CC(=O)c1cccc(NC(=O)NN2CCCCC2Cc2ccc(F)cc2)c1 10.1021/jm049530m
10457573 117048 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 473 8 2 3 6.2 CC(=O)c1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL339110 117048 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 473 8 2 3 6.2 CC(=O)c1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
44289919 101153 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 493 9 2 7 3.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.01.059
CHEMBL295415 101153 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 493 9 2 7 3.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.01.059
44445893 154412 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 541 9 2 6 5.0 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC3CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL398889 154412 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 541 9 2 6 5.0 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC3CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455459 95091 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 467 9 2 4 5.1 CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL255398 95091 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 467 9 2 4 5.1 CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
44455460 95092 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 533 9 3 7 5.3 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2ncco2)cc(-c2ncco2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL255399 95092 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 533 9 3 7 5.3 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2ncco2)cc(-c2ncco2)c1 10.1016/j.bmcl.2007.11.067
44455767 95721 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 483 9 3 5 4.4 CC(=O)c1cc(NC(=O)N[C@@H](C)C[C@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL258309 95721 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 483 9 3 5 4.4 CC(=O)c1cc(NC(=O)N[C@@H](C)C[C@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
11487192 69675 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 428 6 2 4 4.8 Cc1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)no1 10.1021/jm049530m
CHEMBL193526 69675 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 428 6 2 4 4.8 Cc1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)no1 10.1021/jm049530m
44445896 154536 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 531 9 3 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CCO)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL399088 154536 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 531 9 3 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CCO)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445855 154785 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 583 8 2 6 5.3 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C3CCCC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL400172 154785 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 583 8 2 6 5.3 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C3CCCC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
11113940 79582 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 509 8 1 6 5.9 CCOc1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1 10.1016/s0960-894x(01)00176-7
CHEMBL21143 79582 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 509 8 1 6 5.9 CCOc1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1 10.1016/s0960-894x(01)00176-7
44440402 93917 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL248179 93917 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
44295648 102000 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 437 9 3 4 4.1 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@H](C)O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL301601 102000 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 437 9 3 4 4.1 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@H](C)O)c1 10.1016/s0960-894x(02)00206-8
44295555 102054 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 447 8 2 4 3.7 CS(=O)(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL301974 102054 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 447 8 2 4 3.7 CS(=O)(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
22393430 168702 0 None - 1 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL43677 168702 0 None - 1 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
22393339 186736 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 410 7 2 3 4.7 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(Cl)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL48873 186736 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 410 7 2 3 4.7 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(Cl)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
44295306 188883 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 415 8 2 3 5.0 CSc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50726 188883 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 415 8 2 3 5.0 CSc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
22393469 189374 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 394 7 2 3 4.2 N#Cc1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL51286 189374 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 394 7 2 3 4.2 N#Cc1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
44295566 194714 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 479 11 3 4 5.1 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@@H](O)CC(C)C)c1 10.1016/s0960-894x(02)00206-8
CHEMBL53444 194714 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 479 11 3 4 5.1 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@@H](O)CC(C)C)c1 10.1016/s0960-894x(02)00206-8
22393430 168702 0 None - 1 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL43677 168702 0 None - 1 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.01.059
44440429 93643 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 580 8 0 5 5.4 Cc1c(CN(CCc2ccc(F)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL246768 93643 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 580 8 0 5 5.4 Cc1c(CN(CCc2ccc(F)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
44440445 146747 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 577 8 0 6 4.3 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3cccc[n+]3[O-])CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL392430 146747 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 577 8 0 6 4.3 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3cccc[n+]3[O-])CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
44295674 101633 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 483 10 2 3 6.0 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2Cc2ccccc2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL298999 101633 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 483 10 2 3 6.0 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2Cc2ccccc2)c1 10.1016/s0960-894x(02)00206-8
22393362 101689 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 437 7 2 2 5.3 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccccc1C(F)(F)F 10.1016/s0960-894x(02)00206-8
CHEMBL299385 101689 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 437 7 2 2 5.3 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccccc1C(F)(F)F 10.1016/s0960-894x(02)00206-8
9842640 167374 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 376 7 2 3 4.0 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL42948 167374 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 376 7 2 3 4.0 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
44295267 188232 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 431 8 2 3 4.0 C[S+]([O-])c1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL49938 188232 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 431 8 2 3 4.0 C[S+]([O-])c1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
44295406 188364 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 8 2 3 6.0 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(-c2cccs2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50129 188364 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 8 2 3 6.0 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(-c2cccs2)c1 10.1016/s0960-894x(02)00206-8
44295664 188695 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 435 10 2 3 5.5 CCC[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50423 188695 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 435 10 2 3 5.5 CCC[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
22393307 188771 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3F)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50557 188771 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3F)CC2)c1 10.1016/s0960-894x(02)00206-8
44295304 189128 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 9 3 4 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2C(C)(C)O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL51052 189128 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 9 3 4 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2C(C)(C)O)c1 10.1016/s0960-894x(02)00206-8
22393366 192520 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 411 8 2 3 4.5 CC(=O)c1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL52094 192520 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 411 8 2 3 4.5 CC(=O)c1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
9842640 167374 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 376 7 2 3 4.0 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL42948 167374 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 376 7 2 3 4.0 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/j.bmcl.2004.01.059
44349614 118450 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 402 5 0 3 3.6 O=C1CC2(CCc3ccccc32)C(=O)N1CC1CCN(CCc2ccccc2)CC1 10.1021/jm0201767
CHEMBL341144 118450 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 402 5 0 3 3.6 O=C1CC2(CCc3ccccc32)C(=O)N1CC1CCN(CCc2ccccc2)CC1 10.1021/jm0201767
44281791 116271 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 406 7 1 5 4.0 CC(C)OC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL33589 116271 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 406 7 1 5 4.0 CC(C)OC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
11103845 12126 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 455 6 3 3 5.5 C[N+]1(Cc2cc(O)ccc2NC(=O)Nc2cccc(C#N)c2)CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL1184106 12126 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 455 6 3 3 5.5 C[N+]1(Cc2cc(O)ccc2NC(=O)Nc2cccc(C#N)c2)CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL332591 12126 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 455 6 3 3 5.5 C[N+]1(Cc2cc(O)ccc2NC(=O)Nc2cccc(C#N)c2)CCC(Cc2ccccc2)CC1 10.1021/jm0201767
11812807 16578 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 477 8 3 4 5.5 COc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL123917 16578 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 477 8 3 4 5.5 COc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
44447161 94884 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 547 12 3 8 2.3 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)S(C)(=O)=O)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254055 94884 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 547 12 3 8 2.3 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)S(C)(=O)=O)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44447153 153932 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 617 13 3 7 5.6 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)CC23CC4CC(CC(C4)C2)C3)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL398344 153932 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 617 13 3 7 5.6 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)CC23CC4CC(CC(C4)C2)C3)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44419314 83301 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 376 7 3 3 4.1 N#Cc1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
CHEMBL218997 83301 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 376 7 3 3 4.1 N#Cc1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
11828215 114459 1 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 613 12 3 3 7.1 O=C(NCCc1ccc(F)cc1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL333422 114459 1 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 613 12 3 3 7.1 O=C(NCCc1ccc(F)cc1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
11104005 117360 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 602 12 3 4 6.2 O=C(NCCN1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL339752 117360 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 602 12 3 4 6.2 O=C(NCCN1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
11813735 118145 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 562 12 3 4 5.3 CN(C)CCNC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL340797 118145 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 562 12 3 4 5.3 CN(C)CCNC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
11730610 16685 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 485 7 2 5 5.7 CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccccc4)CC2)OCO3)c1 10.1021/jm0201767
CHEMBL124272 16685 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 485 7 2 5 5.7 CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccccc4)CC2)OCO3)c1 10.1021/jm0201767
44390949 64405 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCC2CCN(CCCc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL181311 64405 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCC2CCN(CCCc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.11.006
44512617 195338 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of mouse CCR3Inhibition of mouse CCR3
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL551735 195338 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of mouse CCR3Inhibition of mouse CCR3
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
44295686 163001 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 407 5 1 3 4.6 COc1cccc(NC(=O)N2CCC(N3CCC(Cc4ccccc4)CC3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL417547 163001 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 407 5 1 3 4.6 COc1cccc(NC(=O)N2CCC(N3CCC(Cc4ccccc4)CC3)CC2)c1 10.1016/s0960-894x(02)00206-8
10995218 16616 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 549 12 4 4 5.1 O=C(NCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL124127 16616 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 549 12 4 4 5.1 O=C(NCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
9982077 16587 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 468 6 2 5 5.4 N#Cc1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccccc4)CC2)OCO3)c1 10.1021/jm0201767
CHEMBL123962 16587 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 468 6 2 5 5.4 N#Cc1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccccc4)CC2)OCO3)c1 10.1021/jm0201767
44447373 94675 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 453 9 4 8 1.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)[C@H](C)[C@@H](O)c1ccccc1 10.1016/j.bmcl.2007.11.087
CHEMBL252628 94675 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 453 9 4 8 1.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)[C@H](C)[C@@H](O)c1ccccc1 10.1016/j.bmcl.2007.11.087
10863252 171356 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 447 7 3 3 5.5 O=C(Nc1ccccc1)Nc1ccccc1C(O)CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL446164 171356 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 447 7 3 3 5.5 O=C(Nc1ccccc1)Nc1ccccc1C(O)CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
44295479 101556 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 425 6 1 3 4.6 COc1cccc(NC(=O)N2CCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL298414 101556 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 425 6 1 3 4.6 COc1cccc(NC(=O)N2CCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
11285792 879 34 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from CCR3 expressed in CHO cells
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/jm0509703
801 879 34 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from CCR3 expressed in CHO cells
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/jm0509703
CHEMBL2110727 879 34 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from CCR3 expressed in CHO cells
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/jm0509703
DB11758 879 34 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from CCR3 expressed in CHO cells
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/jm0509703
10983106 16929 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 443 8 2 3 5.5 COc1cccc(NC(=O)NCc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL125282 16929 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 443 8 2 3 5.5 COc1cccc(NC(=O)NCc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
11124782 118469 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 587 11 3 3 7.3 O=C(NCC1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL341306 118469 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 587 11 3 3 7.3 O=C(NCC1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
22393396 168270 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3cccc(F)c3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL43391 168270 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3cccc(F)c3)C2)c1 10.1016/j.bmcl.2004.01.059
11732727 16650 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 429 7 3 3 5.3 O=C(Nc1ccccc1)Nc1ccccc1C(O)CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL124206 16650 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 429 7 3 3 5.3 O=C(Nc1ccccc1)Nc1ccccc1C(O)CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
44440396 153067 1 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 579 8 0 6 5.2 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccccn2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL397599 153067 1 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 579 8 0 6 5.2 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccccn2)n1C 10.1016/j.bmcl.2007.05.035
44440427 93642 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 609 9 0 7 5.2 COc1ccncc1-n1c(=O)c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(C)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL246766 93642 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 609 9 0 7 5.2 COc1ccncc1-n1c(=O)c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(C)n1C 10.1016/j.bmcl.2007.05.035
44295499 189357 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 453 7 1 3 5.4 COc1cccc(NC(=O)N2CCCC(CCN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL51267 189357 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 453 7 1 3 5.4 COc1cccc(NC(=O)N2CCCC(CCN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
44440422 93533 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 622 9 1 6 5.5 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(C(=O)O)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL246348 93533 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 622 9 1 6 5.5 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(C(=O)O)cc2)n1C 10.1016/j.bmcl.2007.05.035
44440440 93644 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 577 8 1 6 4.8 Cc1c(CN(CCc2ccc(N)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL246769 93644 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 577 8 1 6 4.8 Cc1c(CN(CCc2ccc(N)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
44440434 153363 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 563 8 0 6 4.6 Cc1c(CN(CCc2cccnc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL397853 153363 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 563 8 0 6 4.6 Cc1c(CN(CCc2cccnc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
44295409 101664 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 355 5 1 3 3.2 CC(C)(C)C(=O)NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3 10.1016/s0960-894x(02)00206-8
CHEMBL299226 101664 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 355 5 1 3 3.2 CC(C)(C)C(=O)NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3 10.1016/s0960-894x(02)00206-8
44295433 187060 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 441 6 1 4 4.0 COc1cccc(NC(=O)N2CCO[C@@H](CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL49117 187060 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 441 6 1 4 4.0 COc1cccc(NC(=O)N2CCO[C@@H](CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
23497297 16874 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 483 6 3 5 5.4 O=C(Nc1ccc2c[nH]nc2c1)Nc1cc2c(cc1CN1CCC(Cc3ccccc3)CC1)OCO2 10.1021/jm0201767
CHEMBL124966 16874 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 483 6 3 5 5.4 O=C(Nc1ccc2c[nH]nc2c1)Nc1cc2c(cc1CN1CCC(Cc3ccccc3)CC1)OCO2 10.1021/jm0201767
11001953 114133 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 327 7 2 4 2.2 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Cc1ccccc1 10.1016/s0960-894x(01)00248-7
CHEMBL33290 114133 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 327 7 2 4 2.2 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Cc1ccccc1 10.1016/s0960-894x(01)00248-7
11825113 16887 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 381 8 3 3 3.6 O=C(NCCCO)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL125026 16887 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 381 8 3 3 3.6 O=C(NCCCO)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
11762865 16561 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 503 9 2 2 7.1 O=C(NCC(c1ccccc1)c1ccccc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL123807 16561 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 503 9 2 2 7.1 O=C(NCC(c1ccccc1)c1ccccc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
44570714 189794 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of CCR3 at 10 uMInhibition of CCR3 at 10 uM
ChEMBL 565 9 5 6 3.6 CSc1ccc(C(=O)NC2CCC(NC(C)C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 10.1016/j.bmcl.2008.12.062
CHEMBL516224 189794 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of CCR3 at 10 uMInhibition of CCR3 at 10 uM
ChEMBL 565 9 5 6 3.6 CSc1ccc(C(=O)NC2CCC(NC(C)C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 10.1016/j.bmcl.2008.12.062
11048458 118478 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 440 6 3 4 5.4 N#Cc1cccc(NC(=O)Nc2ccc(O)cc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL341343 118478 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 440 6 3 4 5.4 N#Cc1cccc(NC(=O)Nc2ccc(O)cc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
71449114 78947 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 435 7 2 3 5.3 COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCCC(Cc3ccccc3)C2)c1 10.1021/jm049530m
CHEMBL2112987 78947 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 435 7 2 3 5.3 COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCCC(Cc3ccccc3)C2)c1 10.1021/jm049530m
10928173 76543 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 431 6 1 5 4.8 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2cccc(Cl)c2)CC1 10.1016/s0960-894x(01)00176-7
CHEMBL20612 76543 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 431 6 1 5 4.8 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2cccc(Cl)c2)CC1 10.1016/s0960-894x(01)00176-7
10950225 117474 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 438 7 2 3 5.3 N#Cc1cccc(NC(=O)NCc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL339934 117474 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 438 7 2 3 5.3 N#Cc1cccc(NC(=O)NCc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
76316987 103535 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 9 2 6 3.9 Cn1nnnc1-c1cccc(NC(=O)NC[C@@H]2CCCN(CCCCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL3085295 103535 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 9 2 6 3.9 Cn1nnnc1-c1cccc(NC(=O)NC[C@@H]2CCCN(CCCCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
11408397 77959 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL2096695 77959 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
22393329 101126 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL295229 101126 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
44390970 64064 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 533 8 2 6 4.4 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2C(F)(F)F)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL180728 64064 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 533 8 2 6 4.4 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2C(F)(F)F)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44390971 123121 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 541 9 2 6 5.0 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2c2ccccc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL361130 123121 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 541 9 2 6 5.0 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2c2ccccc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44387856 131442 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 447 7 2 3 5.5 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm049530m
CHEMBL369073 131442 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 447 7 2 3 5.5 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm049530m
11465468 167037 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
CHEMBL428881 167037 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
44281521 100402 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 370 7 1 5 3.1 CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1ccc(C)cc1C 10.1016/s0960-894x(01)00248-7
CHEMBL290104 100402 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 370 7 1 5 3.1 CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1ccc(C)cc1C 10.1016/s0960-894x(01)00248-7
10255492 118161 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 502 8 3 4 5.2 CC(=O)c1cccc(NC(=O)Nc2ccc(C(N)=O)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL340853 118161 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 502 8 3 4 5.2 CC(=O)c1cccc(NC(=O)Nc2ccc(C(N)=O)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
11733617 161254 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 485 7 3 4 4.9 N#Cc1cccc(NC(=O)Nc2cccc(C(N)=O)c2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL411956 161254 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 485 7 3 4 4.9 N#Cc1cccc(NC(=O)Nc2cccc(C(N)=O)c2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
44289910 101211 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 529 8 2 6 4.2 Cn1nnnc1-c1cc(Br)cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL295898 101211 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 529 8 2 6 4.2 Cn1nnnc1-c1cc(Br)cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
44290019 101222 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 479 9 2 6 4.5 CC(C)n1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL295970 101222 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 479 9 2 6 4.5 CC(C)n1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
44447149 94944 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 551 12 3 7 4.7 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)C2CCCCC2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254470 94944 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 551 12 3 7 4.7 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)C2CCCCC2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44445862 94454 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 555 8 2 6 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C3CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251274 94454 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 555 8 2 6 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C3CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44390954 63868 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 483 8 2 6 3.8 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)c(F)c3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL180351 63868 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 483 8 2 6 3.8 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)c(F)c3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44445861 94291 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 543 8 2 6 4.5 CCC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL250436 94291 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 543 8 2 6 4.5 CCC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
44447378 154839 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 527 12 4 8 2.8 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)[C@H](O)Cc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL400467 154839 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 527 12 4 8 2.8 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)[C@H](O)Cc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44390838 128510 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL366710 128510 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44419299 141690 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 510 11 3 5 3.9 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(N)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL385607 141690 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 510 11 3 5 3.9 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(N)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
11953409 94216 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 mins
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249854 94216 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 mins
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445877 94214 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 583 8 2 6 5.3 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C3CCCC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249851 94214 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 583 8 2 6 5.3 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C3CCCC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44390964 62598 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 481 8 2 6 4.2 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(Cl)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL178287 62598 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 481 8 2 6 4.2 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(Cl)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44289877 166041 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 5 4.3 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cccc(-c2nnco2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL42562 166041 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 5 4.3 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cccc(-c2nnco2)c1 10.1016/j.bmcl.2004.01.059
11213457 94763 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 465 9 3 6 3.9 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CNCCCc2ccc(F)cc2)c1 10.1016/j.bmcl.2007.11.087
CHEMBL253209 94763 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 465 9 3 6 3.9 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CNCCCc2ccc(F)cc2)c1 10.1016/j.bmcl.2007.11.087
44390919 122053 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 447 8 2 6 3.5 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccccc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL359609 122053 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 447 8 2 6 3.5 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccccc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44419306 141387 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 495 9 2 4 5.0 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL383879 141387 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 495 9 2 4 5.0 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
44295434 101568 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 441 6 1 4 4.0 COc1cccc(NC(=O)N2CCO[C@H](CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL298505 101568 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 441 6 1 4 4.0 COc1cccc(NC(=O)N2CCO[C@H](CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
44295362 162221 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 369 7 2 2 4.3 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccccc1 10.1016/s0960-894x(02)00206-8
CHEMBL416305 162221 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 369 7 2 2 4.3 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccccc1 10.1016/s0960-894x(02)00206-8
22393419 165429 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 399 8 2 3 4.3 COc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL42388 165429 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 399 8 2 3 4.3 COc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
23509697 194950 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 440 6 2 4 3.6 COc1cccc(NC(=O)N2CCNC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL54273 194950 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 440 6 2 4 3.6 COc1cccc(NC(=O)N2CCNC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
22393419 165429 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 399 8 2 3 4.3 COc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL42388 165429 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 399 8 2 3 4.3 COc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.01.059
9951883 168692 0 None - 1 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 381 8 2 3 4.2 COc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL43666 168692 0 None - 1 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 381 8 2 3 4.2 COc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
22393378 188961 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 397 9 2 2 4.0 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NCCc1ccccc1 10.1016/s0960-894x(02)00206-8
CHEMBL50829 188961 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 397 9 2 2 4.0 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NCCc1ccccc1 10.1016/s0960-894x(02)00206-8
9951883 168692 0 None - 1 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 381 8 2 3 4.2 COc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL43666 168692 0 None - 1 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 381 8 2 3 4.2 COc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/j.bmcl.2004.01.059
11734303 168577 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 547 9 3 3 6.5 CC(C)(C)NC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL435812 168577 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 547 9 3 3 6.5 CC(C)(C)NC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
11396966 79005 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 457 6 2 2 6.1 O=C(Nc1cccc(Cl)c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113082 79005 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 457 6 2 2 6.1 O=C(Nc1cccc(Cl)c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44289762 165935 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 380 7 2 3 3.8 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL42507 165935 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 380 7 2 3 3.8 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
11059280 116905 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 442 6 2 3 5.8 N#Cc1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL338389 116905 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 442 6 2 3 5.8 N#Cc1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
11037958 75971 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 465 6 1 5 5.5 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 10.1021/jm300682j
CHEMBL20532 75971 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 465 6 1 5 5.5 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 10.1021/jm300682j
11037958 75971 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 465 6 1 5 5.5 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(01)00176-7
CHEMBL20532 75971 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 465 6 1 5 5.5 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(01)00176-7
44440394 93723 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 578 8 0 5 5.8 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL247160 93723 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 578 8 0 5 5.8 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2007.05.035
9927733 116900 1 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 336 6 2 3 3.1 CCOC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
CHEMBL33838 116900 1 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 336 6 2 3 3.1 CCOC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
9888454 101879 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 421 6 1 3 4.9 COc1cccc(NC(=O)N2CCCC(CN3CCC(Cc4ccccc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL300726 101879 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 421 6 1 3 4.9 COc1cccc(NC(=O)N2CCCC(CN3CCC(Cc4ccccc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
44281522 111512 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 391 6 1 4 3.2 CN(C)C(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL32784 111512 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 391 6 1 4 3.2 CN(C)C(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
11133428 16728 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 413 7 2 2 5.5 O=C(NCc1ccccc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL124321 16728 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 413 7 2 2 5.5 O=C(NCc1ccccc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
10863284 18558 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 449 7 2 2 6.1 O=C(Nc1ccc(F)cc1)Nc1ccccc1CCN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL127590 18558 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 449 7 2 2 6.1 O=C(Nc1ccc(F)cc1)Nc1ccccc1CCN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
44390931 122932 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 7 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NCC2CCN(CCc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL360653 122932 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 7 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NCC2CCN(CCc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.11.006
76320703 103536 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 423 6 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NC[C@@H]2CCCN(Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL3085296 103536 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 423 6 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NC[C@@H]2CCCN(Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
10875472 113659 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 568 10 3 4 6.6 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccncc1 10.1021/jm0201767
CHEMBL332277 113659 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 568 10 3 4 6.6 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccncc1 10.1021/jm0201767
9981262 64855 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCC2CCCN(CCCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL182087 64855 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCC2CCCN(CCCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
10874195 164356 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 459 8 3 4 5.3 COc1cccc(NC(=O)Nc2cc(CO)ccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL421273 164356 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 459 8 3 4 5.3 COc1cccc(NC(=O)Nc2cc(CO)ccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
11112528 16813 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 417 6 2 2 5.9 O=C(Nc1ccccc1)Nc1ccccc1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL124669 16813 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 417 6 2 2 5.9 O=C(Nc1ccccc1)Nc1ccccc1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
44295487 169163 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 444 5 2 3 4.5 O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)Nc1ccc(C(F)(F)F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL440477 169163 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 444 5 2 3 4.5 O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)Nc1ccc(C(F)(F)F)cc1 10.1016/s0960-894x(02)00206-8
11145481 113568 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 496 8 2 3 5.9 O=C(Nc1cccc(CN2CCC(Cc3ccccc3)CC2)c1)NC1CCN(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL332227 113568 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 496 8 2 3 5.9 O=C(Nc1cccc(CN2CCC(Cc3ccccc3)CC2)c1)NC1CCN(Cc2ccccc2)CC1 10.1021/jm0201767
22393395 168865 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccccc3F)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL43818 168865 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccccc3F)C2)c1 10.1016/j.bmcl.2004.01.059
44390857 63630 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 490 9 2 7 3.6 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(N(C)C)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL180082 63630 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 490 9 2 7 3.6 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(N(C)C)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
10939210 16910 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 445 8 2 2 5.6 O=C(NCCc1ccc(F)cc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL125167 16910 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 445 8 2 2 5.6 O=C(NCCc1ccc(F)cc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
11722772 98585 0 None - 1 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 307 7 0 1 5.0 c1ccc(CCCCN2CCC(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
CHEMBL276784 98585 0 None - 1 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 307 7 0 1 5.0 c1ccc(CCCCN2CCC(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
77033 113795 78 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 313 6 2 4 2.3 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
CHEMBL33242 113795 78 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 313 6 2 4 2.3 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
22966052 84224 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 376 7 3 3 4.1 N#Cc1cccc(NC(=O)NCCC[C@@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
CHEMBL220866 84224 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 376 7 3 3 4.1 N#Cc1cccc(NC(=O)NCCC[C@@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
44289959 100419 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 5.0 CC(=O)c1cccc(NC(=O)NCCCN2CC3(Cc4ccc(F)cc4)CCC2CC3)c1 10.1016/j.bmcl.2004.01.059
CHEMBL290276 100419 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 5.0 CC(=O)c1cccc(NC(=O)NCCCN2CC3(Cc4ccc(F)cc4)CCC2CC3)c1 10.1016/j.bmcl.2004.01.059
44290040 172465 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL44817 172465 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
44295259 162555 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 393 6 1 3 3.6 O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL416835 162555 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 393 6 1 3 3.6 O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
9935588 16900 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 496 8 2 3 5.9 O=C(Nc1ccccc1CN1CCC(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL125108 16900 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 496 8 2 3 5.9 O=C(Nc1ccccc1CN1CCC(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1 10.1021/jm0201767
10874991 164358 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 517 9 2 3 6.7 O=C(NCC(c1ccccc1)c1ccccc1)Nc1ccccc1CN1CCC(C(=O)c2ccccc2)CC1 10.1021/jm0201767
CHEMBL421274 164358 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 517 9 2 3 6.7 O=C(NCC(c1ccccc1)c1ccccc1)Nc1ccccc1CN1CCC(C(=O)c2ccccc2)CC1 10.1021/jm0201767
44445874 94514 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 541 9 2 6 5.0 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CC3CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251623 94514 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 541 9 2 6 5.0 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CC3CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455792 95723 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 465 8 2 6 3.9 C[C@@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL258323 95723 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 465 8 2 6 3.9 C[C@@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11214474 71353 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 514 6 2 4 6.7 O=C(Nc1nc2c(Cl)cccc2s1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL195790 71353 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 514 6 2 4 6.7 O=C(Nc1nc2c(Cl)cccc2s1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11442439 124057 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 455 6 2 2 5.9 Cc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1F 10.1021/jm049530m
CHEMBL363166 124057 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 455 6 2 2 5.9 Cc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1F 10.1021/jm049530m
9804542 130284 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
CHEMBL367992 130284 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
44419340 84375 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 451 10 2 3 5.4 C=CCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL221903 84375 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 451 10 2 3 5.4 C=CCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
10140602 166618 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 7 2 6 3.4 C[C@H](CC(=O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL428071 166618 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 7 2 6 3.4 C[C@H](CC(=O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
20636465 84089 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 495 9 4 4 4.3 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2C(=N)N)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL220766 84089 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 495 9 4 4 4.3 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2C(=N)N)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
44346153 15503 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorCompound was tested for its ability to inhibit C-C chemokine receptor type 3 receptor
ChEMBL 519 8 3 5 4.1 C[C@H](O)[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 10.1016/s0960-894x(03)00748-0
CHEMBL121637 15503 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorCompound was tested for its ability to inhibit C-C chemokine receptor type 3 receptor
ChEMBL 519 8 3 5 4.1 C[C@H](O)[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 10.1016/s0960-894x(03)00748-0
11259591 125523 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 455 6 2 2 5.9 Cc1ccc(F)cc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL364673 125523 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 455 6 2 2 5.9 Cc1ccc(F)cc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44346194 15548 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorCompound was tested for its ability to inhibit C-C chemokine receptor type 3 receptor
ChEMBL 501 9 2 5 5.4 COc1cc(NC(=O)N[C@H](C)CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
CHEMBL121905 15548 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorCompound was tested for its ability to inhibit C-C chemokine receptor type 3 receptor
ChEMBL 501 9 2 5 5.4 COc1cc(NC(=O)N[C@H](C)CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
44445879 94215 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 545 7 2 7 4.3 COC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL249852 94215 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 545 7 2 7 4.3 COC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
44440412 151021 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccccc2F)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL395850 151021 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccccc2F)n1C 10.1016/j.bmcl.2007.05.035
44295554 188344 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 415 8 2 3 5.0 CSc1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL50094 188344 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 415 8 2 3 5.0 CSc1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
23509693 191493 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 540 6 1 5 5.2 COc1cccc(NC(=O)N2CCN(C(=O)OC(C)(C)C)C(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL51937 191493 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 540 6 1 5 5.2 COc1cccc(NC(=O)N2CCN(C(=O)OC(C)(C)C)C(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
10029075 116832 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 503 7 2 5 5.9 CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 10.1021/jm0201767
CHEMBL337990 116832 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 503 7 2 5 5.9 CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 10.1021/jm0201767
44440423 146710 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 635 9 1 6 5.7 CC(=O)Nc1ccc(-n2c(=O)c(CN(CCc3ccc(Cl)cc3)C3CCN(C(=O)c4c(F)cccc4F)CC3)c(C)n2C)cc1 10.1016/j.bmcl.2007.05.035
CHEMBL392405 146710 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 635 9 1 6 5.7 CC(=O)Nc1ccc(-n2c(=O)c(CN(CCc3ccc(Cl)cc3)C3CCN(C(=O)c4c(F)cccc4F)CC3)c(C)n2C)cc1 10.1016/j.bmcl.2007.05.035
22393428 188654 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 383 8 2 2 4.0 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NCc1ccccc1 10.1016/s0960-894x(02)00206-8
CHEMBL50354 188654 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 383 8 2 2 4.0 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NCc1ccccc1 10.1016/s0960-894x(02)00206-8
22393333 189404 4 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 351 7 2 2 4.2 O=C(NCCCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1 10.1016/s0960-894x(02)00206-8
CHEMBL51307 189404 4 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 351 7 2 2 4.2 O=C(NCCCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1 10.1016/s0960-894x(02)00206-8
44281523 99688 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 453 8 2 4 4.4 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)NCc1ccccc1)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL284577 99688 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 453 8 2 4 4.4 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)NCc1ccccc1)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
11282712 78535 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)NC2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1021/jm049530m
CHEMBL2112049 78535 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)NC2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1021/jm049530m
22393315 168682 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 376 7 2 3 4.0 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccccc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL43655 168682 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 376 7 2 3 4.0 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccccc3)C2)c1 10.1016/j.bmcl.2004.01.059
11134412 164641 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 465 7 3 3 5.6 O=C(Nc1cc(F)ccc1F)Nc1ccccc1C(O)CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL421634 164641 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 465 7 3 3 5.6 O=C(Nc1cc(F)ccc1F)Nc1ccccc1C(O)CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
10864223 16885 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 517 8 2 5 5.9 COC(=O)c1ccc(NC(=O)Nc2cccc(C(C)=O)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL125012 16885 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 517 8 2 5 5.9 COC(=O)c1ccc(NC(=O)Nc2cccc(C(C)=O)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
44447142 94670 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 589 12 3 7 5.0 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC12CC3CC(CC(C3)C1)C2 10.1016/j.bmcl.2007.11.087
CHEMBL252610 94670 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 589 12 3 7 5.0 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC12CC3CC(CC(C3)C1)C2 10.1016/j.bmcl.2007.11.087
9845853 128475 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 435 7 2 3 5.3 COc1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm049530m
CHEMBL366654 128475 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 435 7 2 3 5.3 COc1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm049530m
44593546 178757 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 531 6 2 6 4.9 CN1CC(C)(NC(=O)Nc2nc(C(C)(C)C)cs2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
CHEMBL468695 178757 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 531 6 2 6 4.9 CN1CC(C)(NC(=O)Nc2nc(C(C)(C)C)cs2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
44445853 154582 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 473 7 3 6 3.5 CC(=O)c1sc(NC(=O)N[C@@H]2CNC[C@@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL399134 154582 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 473 7 3 6 3.5 CC(=O)c1sc(NC(=O)N[C@@H]2CNC[C@@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
11144348 16584 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 424 6 2 3 5.7 N#Cc1cccc(NC(=O)Nc2cccc(CN3CCC(Cc4ccccc4)CC3)c2)c1 10.1021/jm0201767
CHEMBL123957 16584 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 424 6 2 3 5.7 N#Cc1cccc(NC(=O)Nc2cccc(CN3CCC(Cc4ccccc4)CC3)c2)c1 10.1021/jm0201767
11048445 16766 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 439 6 3 3 5.7 O=C(Nc1ccc2[nH]ncc2c1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL124390 16766 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 439 6 3 3 5.7 O=C(Nc1ccc2[nH]ncc2c1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
11091447 169390 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 439 6 3 3 5.7 O=C(Nc1ccc2c[nH]nc2c1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL442210 169390 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 439 6 3 3 5.7 O=C(Nc1ccc2c[nH]nc2c1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
6918497 113430 2 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Inhibitory activity against I-Eotaxin alpha binding to mouse CCR3 receptorsInhibitory activity against I-Eotaxin alpha binding to mouse CCR3 receptors
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL277930 113430 2 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Inhibitory activity against I-Eotaxin alpha binding to mouse CCR3 receptorsInhibitory activity against I-Eotaxin alpha binding to mouse CCR3 receptors
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL331897 113430 2 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Inhibitory activity against I-Eotaxin alpha binding to mouse CCR3 receptorsInhibitory activity against I-Eotaxin alpha binding to mouse CCR3 receptors
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
10916572 18517 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 408 8 0 2 6.2 N#CC(CCCN1CCC(Cc2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL127395 18517 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 408 8 0 2 6.2 N#CC(CCCN1CCC(Cc2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
11102400 118094 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 449 6 2 3 5.7 O=C(Nc1cc(F)ccc1F)Nc1ccccc1CN1CCC(C(=O)c2ccccc2)CC1 10.1021/jm0201767
CHEMBL340656 118094 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 449 6 2 3 5.7 O=C(Nc1cc(F)ccc1F)Nc1ccccc1CN1CCC(C(=O)c2ccccc2)CC1 10.1021/jm0201767
10906911 17989 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 477 8 3 4 5.4 COc1cccc(NC(=O)Nc2ccc(CO)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL126220 17989 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 477 8 3 4 5.4 COc1cccc(NC(=O)Nc2ccc(CO)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
68826395 103506 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 5.0 CC(=O)c1cccc(NC(=O)NCCCN2[C@H]3CC[C@@H]2C[C@H](Cc2ccc(F)cc2)C3)c1 10.1016/j.bmcl.2004.01.059
CHEMBL3085118 103506 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 5.0 CC(=O)c1cccc(NC(=O)NCCCN2[C@H]3CC[C@@H]2C[C@H](Cc2ccc(F)cc2)C3)c1 10.1016/j.bmcl.2004.01.059
10984360 96949 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 537 8 1 7 5.7 CCOC(=O)c1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1 10.1016/s0960-894x(01)00176-7
CHEMBL266181 96949 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 537 8 1 7 5.7 CCOC(=O)c1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1 10.1016/s0960-894x(01)00176-7
44295375 168153 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 419 6 2 4 3.5 CN(C)c1ccc(NC(=O)NCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL433086 168153 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 419 6 2 4 3.5 CN(C)c1ccc(NC(=O)NCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)cc1 10.1016/s0960-894x(02)00206-8
9840971 99739 47 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 342 7 1 5 2.5 CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
CHEMBL284954 99739 47 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 342 7 1 5 2.5 CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
11733139 16904 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 454 7 3 4 5.2 N#Cc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL125132 16904 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 454 7 3 4 5.2 N#Cc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
44289699 167815 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 409 6 2 3 3.9 CC(=O)c1cccc(NC(=O)NCCCN2C[C@@H]3Cc4ccc(F)cc4C[C@H]3C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL43066 167815 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 409 6 2 3 3.9 CC(=O)c1cccc(NC(=O)NCCCN2C[C@@H]3Cc4ccc(F)cc4C[C@H]3C2)c1 10.1016/j.bmcl.2004.01.059
10474776 113657 42 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(03)00748-0
CHEMBL33227 113657 42 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(03)00748-0
44390842 123837 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 7 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL362490 123837 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 7 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
44295485 101872 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 497 12 3 4 5.4 CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccc(F)cc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL300699 101872 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 497 12 3 4 5.4 CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccc(F)cc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
22393287 167964 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL43173 167964 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
11316656 70262 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 441 6 2 2 5.6 O=C(Nc1ccc(F)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL194141 70262 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 441 6 2 2 5.6 O=C(Nc1ccc(F)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
10474776 113657 42 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL33227 113657 42 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
22393287 167964 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL43173 167964 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.01.059
44593553 178367 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 489 6 2 6 3.9 Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1016/j.bmcl.2008.11.002
CHEMBL465272 178367 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 489 6 2 6 3.9 Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1016/j.bmcl.2008.11.002
44593546 178757 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 531 6 2 6 4.9 CN1CC(C)(NC(=O)Nc2nc(C(C)(C)C)cs2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
CHEMBL468695 178757 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 531 6 2 6 4.9 CN1CC(C)(NC(=O)Nc2nc(C(C)(C)C)cs2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
44390911 63807 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 515 8 2 6 4.8 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(Cl)cc3Cl)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL180229 63807 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 515 8 2 6 4.8 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(Cl)cc3Cl)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44390859 131790 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccccc3F)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL369331 131790 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccccc3F)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44447369 94611 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 453 9 4 8 1.8 C[C@@H]([C@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL252222 94611 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 453 9 4 8 1.8 C[C@@H]([C@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44419308 141530 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 509 10 2 4 5.4 CCC(=O)N1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL384649 141530 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 509 10 2 4 5.4 CCC(=O)N1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
44455872 155515 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 467 9 2 4 5.1 CC(=O)c1cc(NC(=O)N[C@@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL404202 155515 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 467 9 2 4 5.1 CC(=O)c1cc(NC(=O)N[C@@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
44295622 101491 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 465 10 3 4 4.7 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@@H](O)C(C)C)c1 10.1016/s0960-894x(02)00206-8
CHEMBL297904 101491 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 465 10 3 4 4.7 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@@H](O)C(C)C)c1 10.1016/s0960-894x(02)00206-8
44295286 188299 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 431 8 2 3 4.0 C[S+]([O-])c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50034 188299 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 431 8 2 3 4.0 C[S+]([O-])c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
44295672 188756 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 439 6 1 3 5.0 COc1cccc(NC(=O)N2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50535 188756 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 439 6 1 3 5.0 COc1cccc(NC(=O)N2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
44295641 189328 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 453 9 4 5 3.4 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2C(C)(O)O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL51244 189328 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 453 9 4 5 3.4 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2C(C)(O)O)c1 10.1016/s0960-894x(02)00206-8
23509695 189739 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 441 6 1 4 4.0 COc1cccc(NC(=O)N2CCOC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL51584 189739 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 441 6 1 4 4.0 COc1cccc(NC(=O)N2CCOC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
44295364 194952 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 10 3 4 4.5 CC[C@@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL54290 194952 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 10 3 4 4.5 CC[C@@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
22257689 16581 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 446 7 1 2 6.0 Cc1ccc(C(=O)NC(CN2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
CHEMBL123943 16581 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 446 7 1 2 6.0 Cc1ccc(C(=O)NC(CN2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
44346211 163893 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 537 10 2 5 6.5 COc1cc(NC(=O)NC(CC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C(C)C)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
CHEMBL420709 163893 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 537 10 2 5 6.5 COc1cc(NC(=O)NC(CC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C(C)C)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
44295130 101197 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 362 6 2 3 3.6 N#Cc1cccc(NC(=O)NCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL295726 101197 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 362 6 2 3 3.6 N#Cc1cccc(NC(=O)NCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
44295528 101907 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 336 4 0 2 4.0 Fc1ccc(CCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL300905 101907 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 336 4 0 2 4.0 Fc1ccc(CCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)cc1 10.1016/s0960-894x(02)00206-8
22393370 189855 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 390 7 2 3 4.3 Cc1ccc(CC2CCN(CCCNC(=O)Nc3cccc(C#N)c3)CC2)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL51676 189855 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 390 7 2 3 4.3 Cc1ccc(CC2CCN(CCCNC(=O)Nc3cccc(C#N)c3)CC2)cc1 10.1016/s0960-894x(02)00206-8
22393398 194917 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 390 8 2 3 4.4 N#Cc1cccc(NC(=O)NCCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL54143 194917 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 390 8 2 3 4.4 N#Cc1cccc(NC(=O)NCCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
10979426 17963 1 None - 0 Human 4.3 pIC50 = 4.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 298 7 3 2 2.7 O=C(NCCCO)NC(Cc1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL126106 17963 1 None - 0 Human 4.3 pIC50 = 4.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 298 7 3 2 2.7 O=C(NCCCO)NC(Cc1ccccc1)c1ccccc1 10.1021/jm0201767
44295102 187951 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 405 7 1 4 3.4 COc1ccc(C(=O)NCCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL49702 187951 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 405 7 1 4 3.4 COc1ccc(C(=O)NCCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)cc1 10.1016/s0960-894x(02)00206-8
10985078 114738 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 635 10 3 3 8.2 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccc(C(F)(F)F)cc1 10.1021/jm0201767
CHEMBL333865 114738 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 635 10 3 3 8.2 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccc(C(F)(F)F)cc1 10.1021/jm0201767
11081509 18543 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 492 6 2 3 6.9 N#Cc1cccc(NC(=O)Nc2c(CN3CCC(Cc4ccc(F)cc4)CC3)ccc3ccccc23)c1 10.1021/jm0201767
CHEMBL127534 18543 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 492 6 2 3 6.9 N#Cc1cccc(NC(=O)Nc2c(CN3CCC(Cc4ccc(F)cc4)CC3)ccc3ccccc23)c1 10.1021/jm0201767
11004826 17988 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 447 7 3 3 5.4 O=C(Nc1ccccc1)Nc1cccc(CO)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL126218 17988 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 447 7 3 3 5.4 O=C(Nc1ccccc1)Nc1cccc(CO)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
44295470 188828 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 425 5 1 3 4.8 COc1cccc(NC(=O)N2CCCC(N3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50645 188828 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 425 5 1 3 4.8 COc1cccc(NC(=O)N2CCCC(N3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
22022834 113337 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 472 7 1 2 6.4 Cc1ccc(C(=O)NC(CN2CC3CCC2CC3Cc2ccc(Cl)c(Cl)c2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
CHEMBL331672 113337 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 472 7 1 2 6.4 Cc1ccc(C(=O)NC(CN2CC3CCC2CC3Cc2ccc(Cl)c(Cl)c2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
11072275 16797 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 632 10 3 5 5.9 COC(=O)N1CCC(NC(=O)NCC(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)(c2ccccc2)c2ccccc2)CC1 10.1021/jm0201767
CHEMBL124585 16797 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 632 10 3 5 5.9 COC(=O)N1CCC(NC(=O)NCC(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)(c2ccccc2)c2ccccc2)CC1 10.1021/jm0201767
25024651 116036 0 None 39 3 Human 6.3 pIC50 = 6.3 Binding
Inhibition of CCR3 in human eosinophil assessed as inhibition of shape change by autofluorescence assayInhibition of CCR3 in human eosinophil assessed as inhibition of shape change by autofluorescence assay
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
CHEMBL3355956 116036 0 None 39 3 Human 6.3 pIC50 = 6.3 Binding
Inhibition of CCR3 in human eosinophil assessed as inhibition of shape change by autofluorescence assayInhibition of CCR3 in human eosinophil assessed as inhibition of shape change by autofluorescence assay
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
10257335 100445 4 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 565 6 2 4 3.5 CCOC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
CHEMBL290565 100445 4 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 565 6 2 4 3.5 CCOC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
11227406 94345 2 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Displacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 mins
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
CHEMBL250689 94345 2 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Displacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 mins
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
44390858 63903 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 423 6 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NCC2CCN(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL180534 63903 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 423 6 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NCC2CCN(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.11.006
10928826 17800 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 472 7 3 4 5.3 N#Cc1cccc(NC(=O)Nc2ccc(CO)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL125884 17800 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 472 7 3 4 5.3 N#Cc1cccc(NC(=O)Nc2ccc(CO)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
9951882 179169 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 381 8 2 3 4.2 COc1cccc(NC(=O)NCCCN2CCCC(Cc3ccccc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL47220 179169 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 381 8 2 3 4.2 COc1cccc(NC(=O)NCCCN2CCCC(Cc3ccccc3)C2)c1 10.1016/j.bmcl.2004.01.059
44295230 189117 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 379 5 1 3 3.2 O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL51038 189117 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 379 5 1 3 3.2 O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
44290041 172728 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 409 6 2 3 3.9 CC(=O)c1cccc(NC(=O)NCCCN2C[C@H]3Cc4ccc(F)cc4C[C@H]3C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL45064 172728 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 409 6 2 3 3.9 CC(=O)c1cccc(NC(=O)NCCCN2C[C@H]3Cc4ccc(F)cc4C[C@H]3C2)c1 10.1016/j.bmcl.2004.01.059
44281790 169213 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 420 6 1 5 4.4 CC(C)(C)OC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL440844 169213 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 420 6 1 5 4.4 CC(C)(C)OC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
11082578 118070 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 603 10 3 3 7.5 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cc(F)ccc1F 10.1021/jm0201767
CHEMBL340491 118070 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 603 10 3 3 7.5 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cc(F)ccc1F 10.1021/jm0201767
44447366 94610 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 453 9 4 8 1.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)[C@H](C)[C@H](O)c1ccccc1 10.1016/j.bmcl.2007.11.087
CHEMBL252221 94610 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 453 9 4 8 1.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)[C@H](C)[C@H](O)c1ccccc1 10.1016/j.bmcl.2007.11.087
44447141 94587 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 523 11 3 7 3.4 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC(F)(F)F 10.1016/j.bmcl.2007.11.087
CHEMBL252034 94587 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 523 11 3 7 3.4 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC(F)(F)F 10.1016/j.bmcl.2007.11.087
9818195 110364 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 311 7 1 3 3.0 CCOC(=O)[C@H](CCc1ccccc1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
CHEMBL32413 110364 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 311 7 1 3 3.0 CCOC(=O)[C@H](CCc1ccccc1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
10995329 18181 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 563 13 4 4 5.5 O=C(NCCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL126978 18181 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 563 13 4 4 5.5 O=C(NCCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
44419327 83217 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 393 8 3 3 4.4 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
CHEMBL218581 83217 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 393 8 3 3 4.4 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
44447155 154923 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 511 11 3 7 2.9 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)C(C)=O)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL401002 154923 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 511 11 3 7 2.9 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)C(C)=O)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44445843 94241 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 587 7 2 7 5.5 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)OC(C)(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL250054 94241 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 587 7 2 7 5.5 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)OC(C)(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44390978 64572 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 7 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NCC2CCCN(CCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL181575 64572 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 7 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NCC2CCCN(CCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
3492 692 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 10.1016/s0960-894x(02)00206-8
9868459 692 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 10.1016/s0960-894x(02)00206-8
CHEMBL50593 692 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 10.1016/s0960-894x(02)00206-8
11179592 69592 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 501 6 2 2 6.2 O=C(Nc1ccc(Br)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL193442 69592 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 501 6 2 2 6.2 O=C(Nc1ccc(Br)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44440431 146462 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 607 9 0 7 5.2 Cc1c(CN(CCc2ccc([N+](=O)[O-])cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL392217 146462 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 607 9 0 7 5.2 Cc1c(CN(CCc2ccc([N+](=O)[O-])cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
44445890 154949 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 543 9 2 7 4.1 CC(=O)CN1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL401115 154949 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 543 9 2 7 4.1 CC(=O)CN1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
11226588 94765 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 547 10 2 6 5.2 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN(CCCc2ccc(F)cc2)CC(F)(F)F)c1 10.1016/j.bmcl.2007.11.087
CHEMBL253211 94765 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 547 10 2 6 5.2 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN(CCCc2ccc(F)cc2)CC(F)(F)F)c1 10.1016/j.bmcl.2007.11.087
44295201 171342 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 479 11 3 4 5.1 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@H](O)CC(C)C)c1 10.1016/s0960-894x(02)00206-8
CHEMBL446144 171342 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 479 11 3 4 5.1 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@H](O)CC(C)C)c1 10.1016/s0960-894x(02)00206-8
44295328 194747 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 437 7 2 2 5.3 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccc(C(F)(F)F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL53673 194747 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 437 7 2 2 5.3 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccc(C(F)(F)F)cc1 10.1016/s0960-894x(02)00206-8
11026367 16482 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 429 7 2 3 5.8 COc1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL123511 16482 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 429 7 2 3 5.8 COc1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
11060510 16502 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 533 10 3 3 6.1 CC(C)NC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL123622 16502 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 533 10 3 3 6.1 CC(C)NC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
11004681 16832 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 439 6 3 3 5.7 O=C(Nc1cccc(CN2CCC(Cc3ccccc3)CC2)c1)Nc1ccc2[nH]ncc2c1 10.1021/jm0201767
CHEMBL124748 16832 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 439 6 3 3 5.7 O=C(Nc1cccc(CN2CCC(Cc3ccccc3)CC2)c1)Nc1ccc2[nH]ncc2c1 10.1021/jm0201767
7072714 110456 3 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 490 11 3 6 3.5 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1016/s0960-894x(01)00248-7
CHEMBL32468 110456 3 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 490 11 3 6 3.5 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1016/s0960-894x(01)00248-7
44440413 93588 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 612 8 0 5 6.4 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(Cl)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL246549 93588 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 612 8 0 5 6.4 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(Cl)cc2)n1C 10.1016/j.bmcl.2007.05.035
10983980 18046 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 505 8 2 5 5.7 COC(=O)c1ccc(NC(=O)Nc2cccc(OC)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL126520 18046 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 505 8 2 5 5.7 COC(=O)c1ccc(NC(=O)Nc2cccc(OC)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
44295463 162004 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 429 7 1 4 3.1 O=S(=O)(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL415950 162004 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 429 7 1 4 3.1 O=S(=O)(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
44419314 83301 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 376 7 3 3 4.1 N#Cc1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
CHEMBL218997 83301 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 376 7 3 3 4.1 N#Cc1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
44346154 168661 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 489 7 2 4 4.7 C[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 10.1016/s0960-894x(03)00748-0
CHEMBL436363 168661 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 489 7 2 4 4.7 C[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 10.1016/s0960-894x(03)00748-0
11511522 67867 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 491 8 0 6 3.1 COc1ccc(OC)c(S(=O)(=O)N2CCC(CN3CCN(Cc4ccc(F)cc4)CC3)CC2)c1 10.1016/j.bmcl.2011.09.013
CHEMBL1910163 67867 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 491 8 0 6 3.1 COc1ccc(OC)c(S(=O)(=O)N2CCC(CN3CCN(Cc4ccc(F)cc4)CC3)CC2)c1 10.1016/j.bmcl.2011.09.013
44295407 189641 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 433 6 1 3 4.3 O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)C12CC3CC(CC(C3)C1)C2 10.1016/s0960-894x(02)00206-8
CHEMBL51507 189641 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 433 6 1 3 4.3 O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)C12CC3CC(CC(C3)C1)C2 10.1016/s0960-894x(02)00206-8
9845853 128475 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 435 7 2 3 5.3 COc1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm049530m
CHEMBL366654 128475 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 435 7 2 3 5.3 COc1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm049530m
10929194 17974 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 500 7 2 5 5.6 COC(=O)c1ccc(NC(=O)Nc2cccc(C#N)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL126163 17974 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 500 7 2 5 5.6 COC(=O)c1ccc(NC(=O)Nc2cccc(C#N)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
44295065 184291 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 405 7 1 4 3.4 COc1ccccc1C(=O)NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3 10.1016/s0960-894x(02)00206-8
CHEMBL48401 184291 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 405 7 1 4 3.4 COc1ccccc1C(=O)NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3 10.1016/s0960-894x(02)00206-8
10474776 113657 42 None - 0 Human 8.2 pIC50 = 8.2 Binding
Agonistic activity against C-C chemokine receptor type 3 by displacing [125I]-MCP-4 radioligand, using CCR3 binding assayAgonistic activity against C-C chemokine receptor type 3 by displacing [125I]-MCP-4 radioligand, using CCR3 binding assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL33227 113657 42 None - 0 Human 8.2 pIC50 = 8.2 Binding
Agonistic activity against C-C chemokine receptor type 3 by displacing [125I]-MCP-4 radioligand, using CCR3 binding assayAgonistic activity against C-C chemokine receptor type 3 by displacing [125I]-MCP-4 radioligand, using CCR3 binding assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
22966050 84136 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 455 10 3 4 4.2 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCO)c1 10.1016/j.bmcl.2006.08.012
CHEMBL220801 84136 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 455 10 3 4 4.2 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCO)c1 10.1016/j.bmcl.2006.08.012
44295282 101657 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 414 8 2 4 4.2 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccc([N+](=O)[O-])cc1 10.1016/s0960-894x(02)00206-8
CHEMBL299170 101657 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 414 8 2 4 4.2 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccc([N+](=O)[O-])cc1 10.1016/s0960-894x(02)00206-8
44295591 188217 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 465 11 3 4 4.9 CCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL49921 188217 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 465 11 3 4 4.9 CCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
44593555 188784 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of CCR3 at 10 uMInhibition of CCR3 at 10 uM
ChEMBL 642 10 4 6 4.9 CSc1ccc(C(=O)NC2CC(NC(=O)OCc3ccccc3)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2008.12.062
CHEMBL505722 188784 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of CCR3 at 10 uMInhibition of CCR3 at 10 uM
ChEMBL 642 10 4 6 4.9 CSc1ccc(C(=O)NC2CC(NC(=O)OCc3ccccc3)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2008.12.062
10874762 16804 1 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 500 7 2 5 5.6 COC(=O)c1cccc(NC(=O)Nc2cccc(C#N)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL124628 16804 1 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 500 7 2 5 5.6 COC(=O)c1cccc(NC(=O)Nc2cccc(C#N)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
44290020 179026 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 435 8 2 4 4.5 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cccc(-n2ccnc2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL47122 179026 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 435 8 2 4 4.5 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cccc(-n2ccnc2)c1 10.1016/j.bmcl.2004.01.059
68826395 103506 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 5.0 CC(=O)c1cccc(NC(=O)NCCCN2[C@H]3CC[C@@H]2C[C@H](Cc2ccc(F)cc2)C3)c1 10.1016/j.bmcl.2004.01.059
CHEMBL3085118 103506 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 5.0 CC(=O)c1cccc(NC(=O)NCCCN2[C@H]3CC[C@@H]2C[C@H](Cc2ccc(F)cc2)C3)c1 10.1016/j.bmcl.2004.01.059
44445850 94082 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 473 7 3 6 3.5 CC(=O)c1sc(NC(=O)N[C@@H]2CNC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249056 94082 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 473 7 3 6 3.5 CC(=O)c1sc(NC(=O)N[C@@H]2CNC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44390898 64565 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 479 9 2 6 4.2 CCc1cc(NC(=O)N[C@@H]2CCCN(CCCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL181528 64565 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 479 9 2 6 4.2 CCc1cc(NC(=O)N[C@@H]2CCCN(CCCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44290029 179147 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 436 8 2 4 4.9 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cccc(-c2cnco2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL47211 179147 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 436 8 2 4 4.9 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cccc(-c2cnco2)c1 10.1016/j.bmcl.2004.01.059
22393474 96550 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 437 7 2 2 5.3 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(C(F)(F)F)c1 10.1016/s0960-894x(02)00206-8
CHEMBL262918 96550 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 437 7 2 2 5.3 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(C(F)(F)F)c1 10.1016/s0960-894x(02)00206-8
44295288 189348 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 447 8 2 4 3.7 CS(=O)(=O)c1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL51259 189348 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 447 8 2 4 3.7 CS(=O)(=O)c1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
44295510 101846 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 401 5 2 4 3.3 N#Cc1cccc(NC(=O)NCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)c1 10.1016/s0960-894x(02)00206-8
CHEMBL300472 101846 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 401 5 2 4 3.3 N#Cc1cccc(NC(=O)NCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)c1 10.1016/s0960-894x(02)00206-8
10591473 64887 10 None - 1 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 279 5 0 1 4.2 c1ccc(CCN2CCC(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
CHEMBL18222 64887 10 None - 1 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 279 5 0 1 4.2 c1ccc(CCN2CCC(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
11812728 16751 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 471 7 2 5 4.8 O=C(NCc1ccc2c(c1)OCO2)Nc1ccccc1CN1CCC(C(=O)c2ccccc2)CC1 10.1021/jm0201767
CHEMBL124336 16751 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 471 7 2 5 4.8 O=C(NCc1ccc2c(c1)OCO2)Nc1ccccc1CN1CCC(C(=O)c2ccccc2)CC1 10.1021/jm0201767
10000888 75977 3 None - 0 Human 6.1 pIC50 = 6.1 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 397 6 1 5 4.2 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccccc2)CC1 10.1016/s0960-894x(01)00176-7
CHEMBL20539 75977 3 None - 0 Human 6.1 pIC50 = 6.1 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 397 6 1 5 4.2 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccccc2)CC1 10.1016/s0960-894x(01)00176-7
10142792 93741 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells
ChEMBL 521 9 5 5 2.8 Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C(=O)NC(C)(C)C)c(C)c1 10.1016/j.bmcl.2007.07.028
CHEMBL247245 93741 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells
ChEMBL 521 9 5 5 2.8 Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C(=O)NC(C)(C)C)c(C)c1 10.1016/j.bmcl.2007.07.028
11069916 16558 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 424 6 2 3 5.7 N#Cc1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL123791 16558 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 424 6 2 3 5.7 N#Cc1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
10993686 116937 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 429 7 2 3 5.8 COc1ccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
CHEMBL338543 116937 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 429 7 2 3 5.8 COc1ccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
57394442 67869 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 407 8 2 3 4.2 O=C(NCCCCN1CCC(Oc2ccc(F)cc2)C1)Nc1ccc(F)c(F)c1 10.1016/j.bmcl.2011.09.013
CHEMBL1910165 67869 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 407 8 2 3 4.2 O=C(NCCCCN1CCC(Oc2ccc(F)cc2)C1)Nc1ccc(F)c(F)c1 10.1016/j.bmcl.2011.09.013
11072063 16605 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 597 11 3 4 7.2 COc1ccc(NC(=O)NCC(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)(c2ccccc2)c2ccccc2)cc1 10.1021/jm0201767
CHEMBL124084 16605 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 597 11 3 4 7.2 COc1ccc(NC(=O)NCC(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)(c2ccccc2)c2ccccc2)cc1 10.1021/jm0201767
11026461 16940 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 434 8 2 3 4.7 O=C(NCCN1CCCCC1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL125325 16940 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 434 8 2 3 4.7 O=C(NCCN1CCCCC1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
11005432 168358 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 487 8 2 5 5.6 COC(=O)c1ccc(CN2CCC(Cc3ccccc3)CC2)c(NC(=O)Nc2cccc(OC)c2)c1 10.1021/jm0201767
CHEMBL434437 168358 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 487 8 2 5 5.6 COC(=O)c1ccc(CN2CCC(Cc3ccccc3)CC2)c(NC(=O)Nc2cccc(OC)c2)c1 10.1021/jm0201767
11385474 78536 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)NC2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1021/jm049530m
CHEMBL2112050 78536 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)NC2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1021/jm049530m
44346023 15095 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 406 7 1 2 5.7 Cc1ccc(C(=O)NC(CC2CCN(Cc3ccc(C)c(C)c3)CC2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
CHEMBL120957 15095 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 406 7 1 2 5.7 Cc1ccc(C(=O)NC(CC2CCN(Cc3ccc(C)c(C)c3)CC2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
10873705 99336 8 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 431 6 1 5 4.8 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)cc2)CC1 10.1016/s0960-894x(01)00176-7
CHEMBL282285 99336 8 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 431 6 1 5 4.8 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)cc2)CC1 10.1016/s0960-894x(01)00176-7
44440421 93530 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 593 8 1 6 5.3 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(N)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL246339 93530 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 593 8 1 6 5.3 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(N)cc2)n1C 10.1016/j.bmcl.2007.05.035
3492 692 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 10.1016/s0960-894x(02)00206-8
9868459 692 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 10.1016/s0960-894x(02)00206-8
CHEMBL50593 692 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 10.1016/s0960-894x(02)00206-8
9800669 109499 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 392 7 1 5 3.7 CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL32210 109499 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 392 7 1 5 3.7 CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
11070954 16779 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 485 7 3 4 4.9 N#Cc1cccc(NC(=O)Nc2ccc(C(N)=O)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL124473 16779 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 485 7 3 4 4.9 N#Cc1cccc(NC(=O)Nc2ccc(C(N)=O)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
10962347 18497 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 516 8 3 4 5.5 CNC(=O)c1ccc(NC(=O)Nc2cccc(C(C)=O)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL127281 18497 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 516 8 3 4 5.5 CNC(=O)c1ccc(NC(=O)Nc2cccc(C(C)=O)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
11763035 169318 1 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 517 8 2 5 5.9 COC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL441656 169318 1 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 517 8 2 5 5.9 COC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
11753159 547 6 None 1 2 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at CCR3 assessed as inhibition of eotaxin bindingAntagonist activity at CCR3 assessed as inhibition of eotaxin binding
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1021/jm300682j
7679 547 6 None 1 2 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at CCR3 assessed as inhibition of eotaxin bindingAntagonist activity at CCR3 assessed as inhibition of eotaxin binding
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1021/jm300682j
CHEMBL2158814 547 6 None 1 2 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at CCR3 assessed as inhibition of eotaxin bindingAntagonist activity at CCR3 assessed as inhibition of eotaxin binding
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1021/jm300682j
44346210 167955 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 531 10 3 6 4.7 COc1cc(NC(=O)N[C@@H](CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)[C@H](C)O)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
CHEMBL431670 167955 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 531 10 3 6 4.7 COc1cc(NC(=O)N[C@@H](CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)[C@H](C)O)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
44295536 188435 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 479 12 3 4 5.3 CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50233 188435 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 479 12 3 4 5.3 CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
9885355 100406 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 363 6 2 4 3.5 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL290119 100406 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 363 6 2 4 3.5 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
44295353 188685 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 350 8 1 2 4.2 O=C(NCCCCN1CCC(Cc2ccccc2)CC1)c1ccccc1 10.1016/s0960-894x(02)00206-8
CHEMBL50401 188685 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 350 8 1 2 4.2 O=C(NCCCCN1CCC(Cc2ccccc2)CC1)c1ccccc1 10.1016/s0960-894x(02)00206-8
71454583 79695 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 4.9 CC(=O)c1cccc(NC(=O)NCCCN2CC3CCC2[C@H](Cc2ccc(F)cc2)C3)c1 10.1016/j.bmcl.2004.01.059
CHEMBL2115412 79695 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 4.9 CC(=O)c1cccc(NC(=O)NCCCN2CC3CCC2[C@H](Cc2ccc(F)cc2)C3)c1 10.1016/j.bmcl.2004.01.059
11015975 16496 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 459 8 3 4 5.3 COc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL123585 16496 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 459 8 3 4 5.3 COc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
44295118 189043 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 405 7 1 4 3.4 COc1cccc(C(=O)NCCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50937 189043 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 405 7 1 4 3.4 COc1cccc(C(=O)NCCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)c1 10.1016/s0960-894x(02)00206-8
57398008 67868 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 393 9 2 3 4.5 COc1ccc(Cl)cc1NC(=O)NCCCCN(C)Cc1ccc(F)cc1 10.1016/j.bmcl.2011.09.013
CHEMBL1910164 67868 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 393 9 2 3 4.5 COc1ccc(Cl)cc1NC(=O)NCCCCN(C)Cc1ccc(F)cc1 10.1016/j.bmcl.2011.09.013
44390893 64374 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 515 8 2 6 4.5 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(C(F)(F)F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL181302 64374 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 515 8 2 6 4.5 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(C(F)(F)F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
132072454 179724 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at human CCR3 expressed in CHO-K1 cells by PathHunter beta-arrestin assayAntagonist activity at human CCR3 expressed in CHO-K1 cells by PathHunter beta-arrestin assay
ChEMBL 558 6 2 8 4.7 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)[C@H](c3[nH]c4ccccc4c3CCn3cc(-c4cccc(Cl)c4)nn3)C[C@@H]21 10.1016/j.bmc.2020.115546
CHEMBL4744046 179724 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at human CCR3 expressed in CHO-K1 cells by PathHunter beta-arrestin assayAntagonist activity at human CCR3 expressed in CHO-K1 cells by PathHunter beta-arrestin assay
ChEMBL 558 6 2 8 4.7 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)[C@H](c3[nH]c4ccccc4c3CCn3cc(-c4cccc(Cl)c4)nn3)C[C@@H]21 10.1016/j.bmc.2020.115546
44295558 101963 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 365 4 1 3 2.8 O=C(NCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL301332 101963 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 365 4 1 3 2.8 O=C(NCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
10934382 16776 30 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 265 4 0 1 4.1 c1ccc(CC2CCN(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
CHEMBL124457 16776 30 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 265 4 0 1 4.1 c1ccc(CC2CCN(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
11828013 17407 1 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 581 11 3 3 6.9 O=C(NCc1ccccc1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL125753 17407 1 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 581 11 3 3 6.9 O=C(NCc1ccccc1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
11049424 117106 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 505 9 3 3 5.3 CNC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL339349 117106 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 505 9 3 3 5.3 CNC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
9972570 69831 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 308 7 0 2 3.8 c1ccc(CCCCN2CCN(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
CHEMBL19375 69831 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 308 7 0 2 3.8 c1ccc(CCCCN2CCN(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
10458117 16586 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 486 6 2 5 5.5 N#Cc1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 10.1021/jm0201767
CHEMBL123961 16586 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 486 6 2 5 5.5 N#Cc1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 10.1021/jm0201767
44346178 114256 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 423 8 1 4 5.0 Cc1ccc(C(=O)NC(CC2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
CHEMBL333040 114256 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 423 8 1 4 5.0 Cc1ccc(C(=O)NC(CC2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
44447377 94831 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 499 11 4 8 2.2 CCN(C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](C)[C@H](O)Cc1ccc(F)cc1 10.1016/j.bmcl.2007.11.087
CHEMBL253666 94831 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 499 11 4 8 2.2 CCN(C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](C)[C@H](O)Cc1ccc(F)cc1 10.1016/j.bmcl.2007.11.087
44295327 188383 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 414 8 2 4 4.2 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(02)00206-8
CHEMBL50158 188383 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 414 8 2 4 4.2 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(02)00206-8
44447150 94945 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 551 12 3 7 3.9 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)CC(F)(F)F)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254471 94945 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 551 12 3 7 3.9 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)CC(F)(F)F)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44295326 169076 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 414 8 2 4 4.2 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc([N+](=O)[O-])c1 10.1016/s0960-894x(02)00206-8
CHEMBL439744 169076 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 414 8 2 4 4.2 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc([N+](=O)[O-])c1 10.1016/s0960-894x(02)00206-8
44387850 60514 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 430 6 2 3 5.2 N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm049530m
CHEMBL175679 60514 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 430 6 2 3 5.2 N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm049530m
11236236 77960 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 448 6 2 3 5.3 N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL2096696 77960 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 448 6 2 3 5.3 N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
11224689 77971 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 448 6 2 3 5.3 N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL2096764 77971 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 448 6 2 3 5.3 N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
10939698 161670 1 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 475 7 2 4 5.7 COC(=O)c1cccc(NC(=O)Nc2ccccc2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL413113 161670 1 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 475 7 2 4 5.7 COC(=O)c1cccc(NC(=O)Nc2ccccc2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
44570582 178417 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 477 10 2 6 3.9 CCCN(CCCc1ccc(F)cc1)C[C@@H]1OC(=O)N(C)C[C@H]1NC(=O)Nc1nc(C)cs1 10.1016/j.bmcl.2008.11.002
CHEMBL465943 178417 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 477 10 2 6 3.9 CCCN(CCCc1ccc(F)cc1)C[C@@H]1OC(=O)N(C)C[C@H]1NC(=O)Nc1nc(C)cs1 10.1016/j.bmcl.2008.11.002
44445846 94423 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 587 7 2 7 5.5 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251078 94423 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 587 7 2 7 5.5 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44390882 122801 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 461 8 2 6 3.8 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(C)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL360529 122801 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 461 8 2 6 3.8 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(C)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44295543 101986 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 427 7 2 2 4.7 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NC12CC3CC(CC(C3)C1)C2 10.1016/s0960-894x(02)00206-8
CHEMBL301503 101986 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 427 7 2 2 4.7 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NC12CC3CC(CC(C3)C1)C2 10.1016/s0960-894x(02)00206-8
11811443 16617 3 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 399 6 2 2 5.8 O=C(Nc1ccccc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL124134 16617 3 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 399 6 2 2 5.8 O=C(Nc1ccccc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
6995527 111899 6 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 221 4 1 3 1.4 CCOC(=O)[C@H](C)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
CHEMBL32878 111899 6 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 221 4 1 3 1.4 CCOC(=O)[C@H](C)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
9889700 118588 17 None - 1 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL34166 118588 17 None - 1 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
11762084 16916 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 446 8 2 3 4.5 O=C(NCCc1ccc(F)cc1)Nc1ccccc1CN1CCN(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL125220 16916 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 446 8 2 3 4.5 O=C(NCCc1ccc(F)cc1)Nc1ccccc1CN1CCN(Cc2ccccc2)CC1 10.1021/jm0201767
11060814 17173 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 567 10 3 3 7.2 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccccc1 10.1021/jm0201767
CHEMBL125618 17173 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 567 10 3 3 7.2 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccccc1 10.1021/jm0201767
66615627 81278 0 None 158 2 Human 9.7 pKi = 9.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 536 8 1 4 6.1 Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.08.103
CHEMBL2158790 81278 0 None 158 2 Human 9.7 pKi = 9.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 536 8 1 4 6.1 Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.08.103
59296081 84083 0 None 7 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 608 9 3 7 2.9 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)N3CCC3)ccc12 10.1016/j.bmcl.2012.09.112
CHEMBL2207654 84083 0 None 7 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 608 9 3 7 2.9 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)N3CCC3)ccc12 10.1016/j.bmcl.2012.09.112
66615619 81271 0 None 79 2 Human 9.3 pKi = 9.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 522 8 1 4 5.7 Cc1c(Cl)ccc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)c1Cl 10.1016/j.bmcl.2012.08.103
CHEMBL2158783 81271 0 None 79 2 Human 9.3 pKi = 9.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 522 8 1 4 5.7 Cc1c(Cl)ccc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)c1Cl 10.1016/j.bmcl.2012.08.103
12001832 81272 0 None 63 2 Human 9.3 pKi = 9.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 522 8 1 4 5.7 Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.08.103
CHEMBL2158784 81272 0 None 63 2 Human 9.3 pKi = 9.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 522 8 1 4 5.7 Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.08.103
16040671 81279 0 None 56 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 502 8 1 4 5.4 Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158791 81279 0 None 56 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 502 8 1 4 5.4 Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
17963201 82266 0 None 31 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 539 5 1 5 5.0 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(C)c4Cl)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171047 82266 0 None 31 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 539 5 1 5 5.0 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(C)c4Cl)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
66615702 81275 0 None 100 2 Human 9.1 pKi = 9.1 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 522 8 1 4 5.8 C[C@](Cc1ccc(F)cc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158787 81275 0 None 100 2 Human 9.1 pKi = 9.1 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 522 8 1 4 5.8 C[C@](Cc1ccc(F)cc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
59296033 84018 0 None 15 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 596 9 3 7 2.7 CN(C)S(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
CHEMBL2207286 84018 0 None 15 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 596 9 3 7 2.7 CN(C)S(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
59295968 84086 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 487 7 3 5 3.3 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3c(F)cccc23)CC1 10.1016/j.bmcl.2012.09.112
CHEMBL2207657 84086 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 487 7 3 5 3.3 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3c(F)cccc23)CC1 10.1016/j.bmcl.2012.09.112
59296099 84090 0 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 494 7 3 5 3.7 Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]nc3C(F)(F)F)CC2)c1Cl 10.1016/j.bmcl.2012.09.112
CHEMBL2207660 84090 0 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 494 7 3 5 3.7 Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]nc3C(F)(F)F)CC2)c1Cl 10.1016/j.bmcl.2012.09.112
46931923 129274 0 None - 1 Human 9.1 pKi = 9.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 537 6 1 5 4.2 Cc1cc(C(=O)N2CCCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670798 129274 0 None - 1 Human 9.1 pKi = 9.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 537 6 1 5 4.2 Cc1cc(C(=O)N2CCCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
59295928 84015 0 None 63 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 581 8 3 7 3.2 Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccc(S(C)(=O)=O)cc34)CC2)c1Cl 10.1016/j.bmcl.2012.09.112
CHEMBL2207283 84015 0 None 63 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 581 8 3 7 3.2 Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccc(S(C)(=O)=O)cc34)CC2)c1Cl 10.1016/j.bmcl.2012.09.112
66615606 81273 0 None 398 2 Human 8.9 pKi = 8.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 513 8 1 5 4.9 Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(C#N)c1Cl 10.1016/j.bmcl.2012.08.103
CHEMBL2158785 81273 0 None 398 2 Human 8.9 pKi = 8.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 513 8 1 5 4.9 Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(C#N)c1Cl 10.1016/j.bmcl.2012.08.103
71462100 81280 0 None 39 2 Human 8.9 pKi = 8.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 502 8 1 4 5.4 Cc1cc(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl 10.1016/j.bmcl.2012.08.103
CHEMBL2158792 81280 0 None 39 2 Human 8.9 pKi = 8.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 502 8 1 4 5.4 Cc1cc(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl 10.1016/j.bmcl.2012.08.103
59295938 84094 0 None 7 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 521 7 3 5 3.6 Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)cc3C(F)(F)F)CC2)c1Cl 10.1016/j.bmcl.2012.09.112
CHEMBL2207664 84094 0 None 7 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 521 7 3 5 3.6 Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)cc3C(F)(F)F)CC2)c1Cl 10.1016/j.bmcl.2012.09.112
66615691 81277 0 None 125 2 Human 8.8 pKi = 8.8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 518 8 1 4 5.9 Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.08.103
CHEMBL2158789 81277 0 None 125 2 Human 8.8 pKi = 8.8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 518 8 1 4 5.9 Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.08.103
9870185 84096 0 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 489 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.113
CHEMBL2207666 84096 0 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 489 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.113
59295931 84212 0 None 5 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 462 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c2ccccc12 10.1016/j.bmcl.2012.09.113
CHEMBL2208429 84212 0 None 5 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 462 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c2ccccc12 10.1016/j.bmcl.2012.09.113
59296010 84214 0 None 3 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 490 7 3 6 2.9 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.113
CHEMBL2208431 84214 0 None 3 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 490 7 3 6 2.9 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.113
71459762 84091 0 None 7 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 452 8 3 5 3.2 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C1CC1 10.1016/j.bmcl.2012.09.112
CHEMBL2207661 84091 0 None 7 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 452 8 3 5 3.2 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C1CC1 10.1016/j.bmcl.2012.09.112
9870185 84096 0 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 489 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.112
CHEMBL2207666 84096 0 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 489 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.112
56967066 129299 0 None - 1 Human 8.8 pKi = 8.8 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 525 7 1 5 4.0 CCN(C)C(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
CHEMBL3670824 129299 0 None - 1 Human 8.8 pKi = 8.8 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 525 7 1 5 4.0 CCN(C)C(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
66615617 81276 0 None 31 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.08.103
CHEMBL2158788 81276 0 None 31 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.08.103
71456722 81281 0 None 39 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 486 8 1 4 4.9 Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158793 81281 0 None 39 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 486 8 1 4 4.9 Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
69262172 81293 1 None 3 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 462 6 1 4 5.5 O=C(O)c1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158822 81293 1 None 3 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 462 6 1 4 5.5 O=C(O)c1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
59295935 84010 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 507 7 3 5 3.6 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(F)ccc12 10.1016/j.bmcl.2012.09.112
CHEMBL2207278 84010 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 507 7 3 5 3.6 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(F)ccc12 10.1016/j.bmcl.2012.09.112
59295978 84085 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 507 7 3 5 3.6 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2c(F)cccc12 10.1016/j.bmcl.2012.09.112
CHEMBL2207656 84085 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 507 7 3 5 3.6 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2c(F)cccc12 10.1016/j.bmcl.2012.09.112
59296066 84093 0 None 5 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 487 7 3 5 3.0 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)cc2C(F)(F)F)CC1 10.1016/j.bmcl.2012.09.112
CHEMBL2207663 84093 0 None 5 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 487 7 3 5 3.0 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)cc2C(F)(F)F)CC1 10.1016/j.bmcl.2012.09.112
69347575 81292 0 None 10 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)[C@@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158821 81292 0 None 10 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)[C@@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
71072040 81307 0 None 5 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 490 8 1 4 5.2 O=C(O)[C@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158835 81307 0 None 5 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 490 8 1 4 5.2 O=C(O)[C@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
71072044 81309 0 None 5 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 524 8 1 4 5.9 O=C(O)[C@H](Cc1ccccc1Cl)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158837 81309 0 None 5 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 524 8 1 4 5.9 O=C(O)[C@H](Cc1ccccc1Cl)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
71072050 81311 0 None 5 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 508 8 1 4 5.4 O=C(O)[C@H](Cc1ccccc1F)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158839 81311 0 None 5 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 508 8 1 4 5.4 O=C(O)[C@H](Cc1ccccc1F)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
71072118 81313 0 None 5 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 508 8 1 4 5.4 O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158841 81313 0 None 5 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 508 8 1 4 5.4 O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
22397445 82239 0 None 2 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 499 4 1 4 5.0 O=C(c1c[nH]c(=O)c2ccccc12)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171020 82239 0 None 2 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 499 4 1 4 5.0 O=C(c1c[nH]c(=O)c2ccccc12)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
57718837 116012 0 None -1 3 Mouse 8.0 pKi = 8 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 414 7 1 2 6.4 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355932 116012 0 None -1 3 Mouse 8.0 pKi = 8 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 414 7 1 2 6.4 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
59295946 84013 0 None 5 2 Human 8.0 pKi = 8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 612 11 5 8 1.7 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NCCO)ccc12 10.1016/j.bmcl.2012.09.112
CHEMBL2207281 84013 0 None 5 2 Human 8.0 pKi = 8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 612 11 5 8 1.7 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NCCO)ccc12 10.1016/j.bmcl.2012.09.112
56965995 129272 0 None - 1 Human 8.0 pKi = 8.0 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 497 6 2 5 3.3 CNC(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
CHEMBL3670796 129272 0 None - 1 Human 8.0 pKi = 8.0 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 497 6 2 5 3.3 CNC(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
69260946 81294 1 None -19 2 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 462 6 1 4 5.5 O=C(O)c1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
CHEMBL2158823 81294 1 None -19 2 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 462 6 1 4 5.5 O=C(O)c1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
71462103 81302 1 None -2 2 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 492 8 1 5 5.2 O=C(O)COc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
CHEMBL2158830 81302 1 None -2 2 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 492 8 1 5 5.2 O=C(O)COc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
17963227 82231 0 None -39 2 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 539 5 0 5 5.1 Cc1ccc(S(=O)(=O)N(C)C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171013 82231 0 None -39 2 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 539 5 0 5 5.1 Cc1ccc(S(=O)(=O)N(C)C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
9910169 82236 0 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 422 7 1 4 4.3 COc1cccc(C(=O)NCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.08.124
CHEMBL2171018 82236 0 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 422 7 1 4 4.3 COc1cccc(C(=O)NCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.08.124
17963336 82263 0 None -5 2 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 536 5 1 6 4.3 N#Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
CHEMBL2171044 82263 0 None -5 2 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 536 5 1 6 4.3 N#Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
118721192 116021 0 None 4 2 Rat 7.0 pKi = 7 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 458 8 1 4 6.0 CCOC(=O)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355941 116021 0 None 4 2 Rat 7.0 pKi = 7 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 458 8 1 4 6.0 CCOC(=O)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
10300214 84199 0 None -6 2 Human 7.0 pKi = 7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 492 9 2 5 5.0 O=C(Nc1ccccc1OCC(O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C1CCC1 10.1016/j.bmcl.2012.09.113
CHEMBL2208416 84199 0 None -6 2 Human 7.0 pKi = 7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 492 9 2 5 5.0 O=C(Nc1ccccc1OCC(O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C1CCC1 10.1016/j.bmcl.2012.09.113
44389685 64733 0 None - 1 Human 7.0 pKi = 7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 459 4 1 2 6.3 Cc1ccccc1NC(=O)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL181894 64733 0 None - 1 Human 7.0 pKi = 7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 459 4 1 2 6.3 Cc1ccccc1NC(=O)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
17989653 81462 0 None - 1 Human 7.0 pKi = 7 Binding
Inhibition of CCR3 receptorInhibition of CCR3 receptor
ChEMBL 301 2 1 3 3.2 Fc1ccc2c(c1)nc(CC(F)(F)F)n2C1CCNCC1 10.1016/j.bmc.2012.09.013
CHEMBL2159765 81462 0 None - 1 Human 7.0 pKi = 7 Binding
Inhibition of CCR3 receptorInhibition of CCR3 receptor
ChEMBL 301 2 1 3 3.2 Fc1ccc2c(c1)nc(CC(F)(F)F)n2C1CCNCC1 10.1016/j.bmc.2012.09.013
44389678 123324 0 None - 1 Human 6.0 pKi = 6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 574 6 1 5 4.6 CS(=O)(=O)N[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL361620 123324 0 None - 1 Human 6.0 pKi = 6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 574 6 1 5 4.6 CS(=O)(=O)N[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44389669 62597 0 None - 1 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cccc(Cl)c3Cl)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178286 62597 0 None - 1 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cccc(Cl)c3Cl)CC2)CC1 10.1016/j.bmcl.2005.01.016
44401055 68682 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 454 7 2 4 4.6 COc1ccc(C(CNC(=O)Nc2ccc(F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL192162 68682 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 454 7 2 4 4.6 COc1ccc(C(CNC(=O)Nc2ccc(F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401192 70585 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 529 7 1 3 6.4 CC(C)(C)c1ccc(C(CNC(=O)Cc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL194943 70585 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 529 7 1 3 6.4 CC(C)(C)c1ccc(C(CNC(=O)Cc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401227 135241 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 421 9 1 4 4.5 COc1ccc(C(CNCCc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL372496 135241 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 421 9 1 4 4.5 COc1ccc(C(CNCCc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401173 69861 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 466 8 2 5 4.5 COc1ccc(NC(=O)NCC(c2ccccc2OC)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL193871 69861 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 466 8 2 5 4.5 COc1ccc(NC(=O)NCC(c2ccccc2OC)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44400953 69281 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 488 6 2 3 5.8 Cc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL192751 69281 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 488 6 2 3 5.8 Cc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401108 69826 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 420 5 2 3 4.1 Cc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(C)CC2)cc1 10.1021/jm040827u
CHEMBL193732 69826 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 420 5 2 3 4.1 Cc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(C)CC2)cc1 10.1021/jm040827u
44401062 70050 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 502 9 1 4 5.6 CN(C)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL193975 70050 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 502 9 1 4 5.6 CN(C)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
118721204 116044 0 None 5 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 532 9 3 2 6.7 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)[nH]c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355964 116044 0 None 5 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 532 9 3 2 6.7 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)[nH]c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
11477767 63027 0 None - 1 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL178818 63027 0 None - 1 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44391171 131796 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 294 1 0 2 4.7 Clc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
CHEMBL369351 131796 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 294 1 0 2 4.7 Clc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
25024650 116040 0 None -21 3 Mouse 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cccc(C(=O)O)n1 10.1016/j.bmcl.2014.11.063
CHEMBL3355960 116040 0 None -21 3 Mouse 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cccc(C(=O)O)n1 10.1016/j.bmcl.2014.11.063
118721203 116043 0 None -1 3 Mouse 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccnc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355963 116043 0 None -1 3 Mouse 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccnc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)c1 10.1016/j.bmcl.2014.11.063
118721194 116024 0 None -229 3 Rat 6.0 pKi = 6.0 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.4 COC(C)c1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355944 116024 0 None -229 3 Rat 6.0 pKi = 6.0 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.4 COC(C)c1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
25024651 116036 0 None -69 3 Rat 6.0 pKi = 6.0 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
CHEMBL3355956 116036 0 None -69 3 Rat 6.0 pKi = 6.0 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
44389719 63020 0 None - 1 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 408 5 0 2 4.6 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178771 63020 0 None - 1 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 408 5 0 2 4.6 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2005.01.016
44389750 166089 0 None - 1 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 469 4 1 2 6.0 O=C(c1cccc2[nH]ccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL425875 166089 0 None - 1 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 469 4 1 2 6.0 O=C(c1cccc2[nH]ccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
44401247 69425 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 492 6 2 3 5.7 O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(F)cc1 10.1021/jm040827u
CHEMBL193332 69425 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 492 6 2 3 5.7 O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(F)cc1 10.1021/jm040827u
44401111 68407 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 480 6 2 3 5.9 CC(C)(C)c1ccc(C(CNC(=O)Nc2ccc(F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL191719 68407 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 480 6 2 3 5.9 CC(C)(C)c1ccc(C(CNC(=O)Nc2ccc(F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44400945 71123 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 455 7 1 3 5.2 CC(C)(C)c1ccc(C(CNC(=O)Cc2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL195473 71123 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 455 7 1 3 5.2 CC(C)(C)c1ccc(C(CNC(=O)Cc2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
44401128 71114 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 462 6 2 3 5.8 CC(C)(C)c1ccc(C(CNC(=O)Nc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL195427 71114 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 462 6 2 3 5.8 CC(C)(C)c1ccc(C(CNC(=O)Nc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44400972 165993 0 None - 1 Human 4.9 pKi = 4.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 337 7 1 3 3.1 Cc1ccc(CCNCC(c2ccccc2)N2CCN(C)CC2)cc1 10.1021/jm040827u
CHEMBL425377 165993 0 None - 1 Human 4.9 pKi = 4.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 337 7 1 3 3.1 Cc1ccc(CCNCC(c2ccccc2)N2CCN(C)CC2)cc1 10.1021/jm040827u
44401053 71067 0 None - 1 Human 4.9 pKi = 4.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 371 8 1 4 3.0 COc1ccc(C(CNCCc2ccc(F)cc2)N2CCN(C)CC2)cc1 10.1021/jm040827u
CHEMBL195197 71067 0 None - 1 Human 4.9 pKi = 4.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 371 8 1 4 3.0 COc1ccc(C(CNCCc2ccc(F)cc2)N2CCN(C)CC2)cc1 10.1021/jm040827u
44401255 69857 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.5 COc1ccccc1CCNCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
CHEMBL193850 69857 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.5 COc1ccccc1CCNCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
44389674 62633 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 469 4 1 2 6.0 O=C(c1ccc2[nH]ccc2c1)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178367 62633 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 469 4 1 2 6.0 O=C(c1ccc2[nH]ccc2c1)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
71451391 81269 0 None 12 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 472 8 1 4 4.5 Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158781 81269 0 None 12 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 472 8 1 4 4.5 Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
10005242 81290 0 None 3 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)C(c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158819 81290 0 None 3 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)C(c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
23102749 82234 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 6 1 5 4.3 Cc1c(Cl)ccc(OC2CCN(C3CCN(S(=O)(=O)NC(=O)c4ccccc4)CC3)CC2)c1Cl 10.1016/j.bmcl.2012.08.124
CHEMBL2171016 82234 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 6 1 5 4.3 Cc1c(Cl)ccc(OC2CCN(C3CCN(S(=O)(=O)NC(=O)c4ccccc4)CC3)CC2)c1Cl 10.1016/j.bmcl.2012.08.124
59295926 84218 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 474 7 2 6 3.6 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cnnc2ccccc12 10.1016/j.bmcl.2012.09.113
CHEMBL2208435 84218 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 474 7 2 6 3.6 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cnnc2ccccc12 10.1016/j.bmcl.2012.09.113
59295914 84084 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 638 9 4 8 2.2 CC1(O)CN(S(=O)(=O)c2ccc3c(C(=O)NC[C@@H](O)CN4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)c[nH]c(=O)c3c2)C1 10.1016/j.bmcl.2012.09.112
CHEMBL2207655 84084 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 638 9 4 8 2.2 CC1(O)CN(S(=O)(=O)c2ccc3c(C(=O)NC[C@@H](O)CN4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)c[nH]c(=O)c3c2)C1 10.1016/j.bmcl.2012.09.112
11952525 116038 0 None 21 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 562 10 0 5 8.0 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355958 116038 0 None 21 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 562 10 0 5 8.0 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)cc1 10.1016/j.bmcl.2014.11.063
11952526 116033 0 None -24 3 Mouse 6.9 pKi = 6.9 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 534 9 1 4 7.5 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355953 116033 0 None -24 3 Mouse 6.9 pKi = 6.9 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 534 9 1 4 7.5 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
44391160 123288 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 413 1 1 4 5.6 CC(C)(C)c1csc2nc3n(c(=N)c12)CC/C3=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL361430 123288 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 413 1 1 4 5.6 CC(C)(C)c1csc2nc3n(c(=N)c12)CC/C3=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
44401004 70570 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 471 8 1 3 5.5 Fc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL194885 70570 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 471 8 1 3 5.5 Fc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
44389699 63918 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 445 4 1 3 5.1 Nc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2005.01.016
CHEMBL180599 63918 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 445 4 1 3 5.1 Nc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2005.01.016
71462102 81288 0 None -6 2 Human 6.9 pKi = 6.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 478 7 1 5 4.4 O=C(O)C(c1ccccc1)N1CCO[C@@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2012.08.103
CHEMBL2158817 81288 0 None -6 2 Human 6.9 pKi = 6.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 478 7 1 5 4.4 O=C(O)C(c1ccccc1)N1CCO[C@@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2012.08.103
71455217 82261 0 None -3 2 Human 6.9 pKi = 6.9 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
CHEMBL2171042 82261 0 None -3 2 Human 6.9 pKi = 6.9 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
17963141 82268 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 491 5 1 5 4.1 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171049 82268 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 491 5 1 5 4.1 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
71459825 84200 0 None 3 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 433 8 2 5 3.9 N#Cc1ccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/j.bmcl.2012.09.113
CHEMBL2208417 84200 0 None 3 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 433 8 2 5 3.9 N#Cc1ccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/j.bmcl.2012.09.113
71463288 84204 0 None -6 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 441 8 1 5 5.0 COc1cccc(SC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
CHEMBL2208421 84204 0 None -6 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 441 8 1 5 5.0 COc1cccc(SC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
44400992 69957 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 474 6 2 3 5.8 O=C(NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1)Nc1cc(Cl)cc(Cl)c1 10.1021/jm040827u
CHEMBL193931 69957 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 474 6 2 3 5.8 O=C(NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1)Nc1cc(Cl)cc(Cl)c1 10.1021/jm040827u
44389747 169203 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 424 5 0 2 5.1 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cccc(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL440750 169203 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 424 5 0 2 5.1 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cccc(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
44401135 69653 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 527 8 1 3 6.8 FC(F)(F)c1ccc(C(CNCCc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL193507 69653 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 527 8 1 3 6.8 FC(F)(F)c1ccc(C(CNCCc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
118721187 116016 0 None -1 3 Mouse 6.9 pKi = 6.9 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(OC)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355936 116016 0 None -1 3 Mouse 6.9 pKi = 6.9 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(OC)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721188 116017 0 None -2 3 Mouse 5.9 pKi = 5.9 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C(N)=O)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355937 116017 0 None -2 3 Mouse 5.9 pKi = 5.9 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C(N)=O)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721200 116034 0 None -275 3 Rat 5.9 pKi = 5.9 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 558 9 1 6 7.0 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(-c2nnn[nH]2)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355954 116034 0 None -275 3 Rat 5.9 pKi = 5.9 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 558 9 1 6 7.0 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(-c2nnn[nH]2)cc1 10.1016/j.bmcl.2014.11.063
44401202 70129 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 542 6 2 3 6.5 O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(C(F)(F)F)cc1 10.1021/jm040827u
CHEMBL194025 70129 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 542 6 2 3 6.5 O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(C(F)(F)F)cc1 10.1021/jm040827u
44401183 70153 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 459 8 1 3 5.5 FC(F)(F)c1ccc(CCNCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL194040 70153 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 459 8 1 3 5.5 FC(F)(F)c1ccc(CCNCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44389709 63705 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 445 4 1 3 5.1 Nc1ccc(C(=O)N2CCC(N3CCC(Cc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2005.01.016
CHEMBL180122 63705 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 445 4 1 3 5.1 Nc1ccc(C(=O)N2CCC(N3CCC(Cc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2005.01.016
44389688 64545 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 495 4 0 3 6.3 C[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL181460 64545 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 495 4 0 3 6.3 C[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44391330 64021 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 322 2 0 2 5.5 CCC1C/C(=C\c2ccccc2Cl)C2=Nc3ccccc3CN21 10.1016/j.bmcl.2004.11.039
CHEMBL180721 64021 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 322 2 0 2 5.5 CCC1C/C(=C\c2ccccc2Cl)C2=Nc3ccccc3CN21 10.1016/j.bmcl.2004.11.039
44389721 64283 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1nccc2ccccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL180988 64283 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1nccc2ccccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
44391276 122953 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 278 1 0 2 4.2 Fc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
CHEMBL360738 122953 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 278 1 0 2 4.2 Fc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
44391297 132488 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 288 2 0 2 4.6 CCc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
CHEMBL369778 132488 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 288 2 0 2 4.6 CCc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
44391307 168312 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 337 2 0 3 4.7 CN(C)c1ccc(/C=C2\CCN3Cc4ccccc4N=C23)c(Cl)c1 10.1016/j.bmcl.2004.11.039
CHEMBL434151 168312 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 337 2 0 3 4.7 CN(C)c1ccc(/C=C2\CCN3Cc4ccccc4N=C23)c(Cl)c1 10.1016/j.bmcl.2004.11.039
118721191 116020 0 None -331 3 Rat 5.9 pKi = 5.9 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 444 8 1 3 6.5 COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355940 116020 0 None -331 3 Rat 5.9 pKi = 5.9 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 444 8 1 3 6.5 COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
70790201 129278 0 None - 1 Human 5.9 pKi = 5.9 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 440 5 0 4 3.7 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)N(C)c3ccccn3)CC2)ccc1Cl nan
CHEMBL3670803 129278 0 None - 1 Human 5.9 pKi = 5.9 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 440 5 0 4 3.7 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)N(C)c3ccccn3)CC2)ccc1Cl nan
44389695 63930 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 424 5 0 2 5.1 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL180651 63930 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 424 5 0 2 5.1 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2005.01.016
44389712 63096 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 442 5 0 2 5.3 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)cc3F)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178916 63096 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 442 5 0 2 5.3 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)cc3F)CC2)CC1 10.1016/j.bmcl.2005.01.016
44401086 70531 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 474 6 2 3 5.5 O=C(NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(C(F)(F)F)cc1 10.1021/jm040827u
CHEMBL194715 70531 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 474 6 2 3 5.5 O=C(NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(C(F)(F)F)cc1 10.1021/jm040827u
44401251 69426 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 498 7 2 4 5.4 COc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL193334 69426 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 498 7 2 4 5.4 COc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
11283679 64362 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4cccnc4n3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL181273 64362 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4cccnc4n3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
17963315 82252 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 511 5 1 5 4.4 O=C(NS(=O)(=O)c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171033 82252 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 511 5 1 5 4.4 O=C(NS(=O)(=O)c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
59296109 84211 0 None 12 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 500 8 2 6 3.0 CS(=O)(=O)c1ccccc1C(=O)NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2012.09.113
CHEMBL2208428 84211 0 None 12 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 500 8 2 6 3.0 CS(=O)(=O)c1ccccc1C(=O)NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2012.09.113
59296077 84008 0 None 5 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 547 8 3 7 2.5 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(S(C)(=O)=O)ccc23)CC1 10.1016/j.bmcl.2012.09.112
CHEMBL2207276 84008 0 None 5 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 547 8 3 7 2.5 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(S(C)(=O)=O)ccc23)CC1 10.1016/j.bmcl.2012.09.112
44400973 127523 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.5 COc1ccc(C(CNC(=O)Nc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL366231 127523 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.5 COc1ccc(C(CNC(=O)Nc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
69260851 81295 1 None -2 2 Human 6.8 pKi = 6.8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 462 6 1 4 5.5 O=C(O)c1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
CHEMBL2158824 81295 1 None -2 2 Human 6.8 pKi = 6.8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 462 6 1 4 5.5 O=C(O)c1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
10143016 82273 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 6 1 5 4.5 O=C(NS(=O)(=O)Cc1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171215 82273 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 6 1 5 4.5 O=C(NS(=O)(=O)Cc1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
71454365 84201 0 None 1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 465 8 2 6 4.6 O[C@@H](CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)COc1ccc2ncsc2c1 10.1016/j.bmcl.2012.09.113
CHEMBL2208418 84201 0 None 1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 465 8 2 6 4.6 O[C@@H](CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)COc1ccc2ncsc2c1 10.1016/j.bmcl.2012.09.113
59296073 84205 0 None -1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 483 8 2 6 3.0 N#Cc1cccc(S(=O)(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
CHEMBL2208422 84205 0 None -1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 483 8 2 6 3.0 N#Cc1cccc(S(=O)(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
44401172 124191 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 445 10 1 5 4.4 COc1ccccc1CCNCC(c1ccccc1OC)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
CHEMBL363409 124191 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 445 10 1 5 4.4 COc1ccccc1CCNCC(c1ccccc1OC)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
25024651 116036 0 None 39 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
CHEMBL3355956 116036 0 None 39 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
44391296 65303 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 328 1 0 2 5.0 FC(F)(F)c1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
CHEMBL182889 65303 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 328 1 0 2 5.0 FC(F)(F)c1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
44389722 64284 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 538 5 1 4 5.2 CC(=O)N[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL180989 64284 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 538 5 1 4 5.2 CC(=O)N[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44401052 70079 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 496 9 1 4 5.5 CN(C)c1ccc(C(CNCCc2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL193991 70079 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 496 9 1 4 5.5 CN(C)c1ccc(C(CNCCc2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
56967062 129291 0 None - 1 Human 7.8 pKi = 7.8 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 531 6 1 5 4.0 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)n1 nan
CHEMBL3670816 129291 0 None - 1 Human 7.8 pKi = 7.8 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 531 6 1 5 4.0 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)n1 nan
44391318 65702 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 328 1 0 2 5.3 Clc1ccc(/C=C2\CCN3Cc4ccccc4N=C23)c(Cl)c1 10.1016/j.bmcl.2004.11.039
CHEMBL183441 65702 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 328 1 0 2 5.3 Clc1ccc(/C=C2\CCN3Cc4ccccc4N=C23)c(Cl)c1 10.1016/j.bmcl.2004.11.039
118721199 116029 0 None 2 2 Rat 5.8 pKi = 5.8 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 440 8 2 3 5.9 CCc1[nH]c2cc(C(=O)O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355949 116029 0 None 2 2 Rat 5.8 pKi = 5.8 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 440 8 2 3 5.9 CCc1[nH]c2cc(C(=O)O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
25024650 116040 0 None -338 3 Rat 5.8 pKi = 5.8 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cccc(C(=O)O)n1 10.1016/j.bmcl.2014.11.063
CHEMBL3355960 116040 0 None -338 3 Rat 5.8 pKi = 5.8 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cccc(C(=O)O)n1 10.1016/j.bmcl.2014.11.063
44401235 69842 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.5 COc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL193810 69842 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.5 COc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44400995 71099 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 505 7 2 4 5.9 CN(C)c1ccc(NC(=O)NCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL195353 71099 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 505 7 2 4 5.9 CN(C)c1ccc(NC(=O)NCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401188 69817 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 428 9 1 4 4.4 CN(C)c1ccc(CCNCC(c2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL193656 69817 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 428 9 1 4 4.4 CN(C)c1ccc(CCNCC(c2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
44401047 71130 0 None - 1 Human 6.8 pKi = 6.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 462 7 2 3 5.7 Cc1ccc(NC(=O)NCC(CC(C)C)N2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1021/jm040827u
CHEMBL195495 71130 0 None - 1 Human 6.8 pKi = 6.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 462 7 2 3 5.7 Cc1ccc(NC(=O)NCC(CC(C)C)N2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1021/jm040827u
118721190 116019 0 None 5 3 Mouse 7.8 pKi = 7.8 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 416 7 2 3 5.3 OCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355939 116019 0 None 5 3 Mouse 7.8 pKi = 7.8 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 416 7 2 3 5.3 OCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
11214422 123661 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3cccc4cccnc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL362040 123661 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3cccc4cccnc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44391258 122394 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 328 1 0 2 5.3 Clc1cccc(Cl)c1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
CHEMBL360075 122394 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 328 1 0 2 5.3 Clc1cccc(Cl)c1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
67114884 129277 0 None - 1 Human 7.7 pKi = 7.7 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 6 1 6 3.1 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N4CCOCC4)ccn3)CC2)ccc1Cl nan
CHEMBL3670802 129277 0 None - 1 Human 7.7 pKi = 7.7 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 6 1 6 3.1 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N4CCOCC4)ccn3)CC2)ccc1Cl nan
71072115 81258 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 515 8 1 5 5.1 N#Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
CHEMBL2158770 81258 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 515 8 1 5 5.1 N#Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
71072081 81261 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
CHEMBL2158773 81261 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
71072113 81262 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
CHEMBL2158774 81262 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
11444350 81265 0 None 7 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 558 8 1 4 6.3 O=C(O)[C@H](Cc1cccc(C(F)(F)F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158777 81265 0 None 7 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 558 8 1 4 6.3 O=C(O)[C@H](Cc1cccc(C(F)(F)F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
71449584 81296 1 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)Cc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158825 81296 1 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)Cc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
69347719 81303 1 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)c1ccccc1CN1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158831 81303 1 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)c1ccccc1CN1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
71460419 81310 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 524 8 1 4 5.9 O=C(O)[C@H](Cc1ccc(Cl)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158838 81310 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 524 8 1 4 5.9 O=C(O)[C@H](Cc1ccc(Cl)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
17963334 82257 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171038 82257 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
59296064 84206 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 447 7 2 5 3.5 N#Cc1cccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
CHEMBL2208423 84206 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 447 7 2 5 3.5 N#Cc1cccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
59295960 84097 0 None 12 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 532 8 4 6 2.6 NC(=O)c1c(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.09.112
CHEMBL2207667 84097 0 None 12 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 532 8 4 6 2.6 NC(=O)c1c(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.09.112
118721197 116027 0 None 19 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(OC)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355947 116027 0 None 19 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(OC)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44389730 64598 0 None - 1 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 442 5 0 2 5.3 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)c(F)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL181678 64598 0 None - 1 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 442 5 0 2 5.3 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)c(F)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
70790198 129271 0 None - 1 Human 6.7 pKi = 6.7 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 454 6 1 4 4.2 CCc1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
CHEMBL3670795 129271 0 None - 1 Human 6.7 pKi = 6.7 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 454 6 1 4 4.2 CCc1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
44401056 69848 0 None - 1 Human 5.7 pKi = 5.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 492 7 2 4 5.8 COc1ccc(NC(=O)NCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL193827 69848 0 None - 1 Human 5.7 pKi = 5.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 492 7 2 4 5.8 COc1ccc(NC(=O)NCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
71462389 82243 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 5 1 4 4.8 O=C(O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
CHEMBL2171024 82243 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 5 1 4 4.8 O=C(O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
71462390 82245 0 None -6 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 500 5 1 6 4.3 O=C(c1ccc(-c2nn[nH]n2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171026 82245 0 None -6 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 500 5 1 6 4.3 O=C(c1ccc(-c2nn[nH]n2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
59296114 84208 0 None -12 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 480 7 2 6 3.4 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cn2cc(F)ccc2n1 10.1016/j.bmcl.2012.09.113
CHEMBL2208425 84208 0 None -12 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 480 7 2 6 3.4 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cn2cc(F)ccc2n1 10.1016/j.bmcl.2012.09.113
67114949 129285 0 None - 1 Human 8.6 pKi = 8.6 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 7 1 5 4.4 Cc1cc(C(=O)N(C)C(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670810 129285 0 None - 1 Human 8.6 pKi = 8.6 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 7 1 5 4.4 Cc1cc(C(=O)N(C)C(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
56967064 129295 0 None - 1 Human 8.6 pKi = 8.6 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 537 7 1 5 4.2 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)cc(C4CC4)n3)CC2)ccc1Cl nan
CHEMBL3670820 129295 0 None - 1 Human 8.6 pKi = 8.6 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 537 7 1 5 4.2 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)cc(C4CC4)n3)CC2)ccc1Cl nan
59295939 84213 0 None 12 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 461 7 3 4 4.1 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c2ccccc12 10.1016/j.bmcl.2012.09.113
CHEMBL2208430 84213 0 None 12 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 461 7 3 4 4.1 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c2ccccc12 10.1016/j.bmcl.2012.09.113
59296000 84215 0 None 7 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 478 6 3 6 3.1 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)n1c(=O)[nH]c2ccccc21 10.1016/j.bmcl.2012.09.113
CHEMBL2208432 84215 0 None 7 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 478 6 3 6 3.1 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)n1c(=O)[nH]c2ccccc21 10.1016/j.bmcl.2012.09.113
59296104 84216 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 503 7 2 5 3.8 CN(C[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C(=O)c1c[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.113
CHEMBL2208433 84216 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 503 7 2 5 3.8 CN(C[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C(=O)c1c[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.113
59295974 84102 0 None 19 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 581 8 3 7 3.2 Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4cc(S(C)(=O)=O)ccc34)CC2)c1Cl 10.1016/j.bmcl.2012.09.112
CHEMBL2207672 84102 0 None 19 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 581 8 3 7 3.2 Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4cc(S(C)(=O)=O)ccc34)CC2)c1Cl 10.1016/j.bmcl.2012.09.112
11179794 64293 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3nccc4ccccc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL181034 64293 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3nccc4ccccc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44389770 123821 0 None - 1 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 552 6 1 4 5.5 CC(=O)NC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL362401 123821 0 None - 1 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 552 6 1 4 5.5 CC(=O)NC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44400954 127055 0 None - 1 Human 5.7 pKi = 5.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 518 6 2 3 7.1 CC(C)(C)c1ccc(NC(=O)NCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL365584 127055 0 None - 1 Human 5.7 pKi = 5.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 518 6 2 3 7.1 CC(C)(C)c1ccc(NC(=O)NCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
118721186 116015 0 None -2 3 Mouse 6.7 pKi = 6.7 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(O)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355935 116015 0 None -2 3 Mouse 6.7 pKi = 6.7 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(O)cc2)CC1 10.1016/j.bmcl.2014.11.063
44400982 71125 0 None - 1 Human 6.7 pKi = 6.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 477 9 1 4 5.8 COc1ccccc1CCNCC(c1ccc(C(C)(C)C)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
CHEMBL195480 71125 0 None - 1 Human 6.7 pKi = 6.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 477 9 1 4 5.8 COc1ccccc1CCNCC(c1ccc(C(C)(C)C)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
44401252 70816 0 None - 1 Human 4.7 pKi = 4.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 323 7 1 3 2.8 CN1CCN(C(CNCCc2ccccc2)c2ccccc2)CC1 10.1021/jm040827u
CHEMBL195093 70816 0 None - 1 Human 4.7 pKi = 4.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 323 7 1 3 2.8 CN1CCN(C(CNCCc2ccccc2)c2ccccc2)CC1 10.1021/jm040827u
44401225 69960 0 None - 1 Human 6.7 pKi = 6.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 515 8 1 3 7.1 CC(C)(C)c1ccc(C(CNCCc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL193938 69960 0 None - 1 Human 6.7 pKi = 6.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 515 8 1 3 7.1 CC(C)(C)c1ccc(C(CNCCc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401067 168425 0 None - 1 Human 5.7 pKi = 5.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 450 7 2 4 4.8 COc1ccc(C(CNC(=O)Nc2ccc(C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL434918 168425 0 None - 1 Human 5.7 pKi = 5.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 450 7 2 4 4.8 COc1ccc(C(CNC(=O)Nc2ccc(C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44389690 64667 0 None - 1 Human 5.7 pKi = 5.7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 426 5 0 2 4.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(F)cc(F)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL181827 64667 0 None - 1 Human 5.7 pKi = 5.7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 426 5 0 2 4.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(F)cc(F)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
11386642 63090 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 507 5 0 3 6.5 C=C[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL178887 63090 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 507 5 0 3 6.5 C=C[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
56966925 129267 0 None - 1 Human 7.6 pKi = 7.6 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 483 6 2 5 3.0 CNC(=O)c1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
CHEMBL3670791 129267 0 None - 1 Human 7.6 pKi = 7.6 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 483 6 2 5 3.0 CNC(=O)c1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
24937092 116037 0 None -2 2 Mouse 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 500 10 0 5 6.4 CCOC(=O)Cn1c(CC)c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc21 10.1016/j.bmcl.2014.11.063
CHEMBL3355957 116037 0 None -2 2 Mouse 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 500 10 0 5 6.4 CCOC(=O)Cn1c(CC)c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc21 10.1016/j.bmcl.2014.11.063
118721186 116015 0 None -29 3 Rat 5.6 pKi = 5.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(O)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355935 116015 0 None -29 3 Rat 5.6 pKi = 5.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(O)cc2)CC1 10.1016/j.bmcl.2014.11.063
44401109 71081 0 None - 1 Human 6.6 pKi = 6.6 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 515 8 1 3 6.8 CC(C)(C)c1ccc(C(CNCCc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL195293 71081 0 None - 1 Human 6.6 pKi = 6.6 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 515 8 1 3 6.8 CC(C)(C)c1ccc(C(CNCCc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
56966998 129289 0 None - 1 Human 6.6 pKi = 6.6 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 527 7 1 6 3.3 COc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670814 129289 0 None - 1 Human 6.6 pKi = 6.6 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 527 7 1 6 3.3 COc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
118721194 116024 0 None -5 3 Mouse 7.6 pKi = 7.6 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.4 COC(C)c1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355944 116024 0 None -5 3 Mouse 7.6 pKi = 7.6 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.4 COC(C)c1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
71460416 81264 0 None 2 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 520 9 1 5 5.3 COc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
CHEMBL2158776 81264 0 None 2 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 520 9 1 5 5.3 COc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
71456725 81298 1 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)Cc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
CHEMBL2158827 81298 1 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)Cc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
71072057 81312 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 508 8 1 4 5.4 O=C(O)[C@H](Cc1cccc(F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158840 81312 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 508 8 1 4 5.4 O=C(O)[C@H](Cc1cccc(F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
17963332 82259 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 541 6 1 6 4.4 COc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171040 82259 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 541 6 1 6 4.4 COc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
17963153 82265 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4Cl)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171046 82265 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4Cl)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
59295982 84014 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 568 8 4 7 2.1 NS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
CHEMBL2207282 84014 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 568 8 4 7 2.1 NS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
44391331 64834 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 394 4 0 2 6.3 CCCCC1C/C(=C\c2ccccc2Br)C2=Nc3ccccc3CN21 10.1016/j.bmcl.2004.11.039
CHEMBL181984 64834 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 394 4 0 2 6.3 CCCCC1C/C(=C\c2ccccc2Br)C2=Nc3ccccc3CN21 10.1016/j.bmcl.2004.11.039
44389698 64370 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(Cl)ccc3Cl)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL181290 64370 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(Cl)ccc3Cl)CC2)CC1 10.1016/j.bmcl.2005.01.016
69347980 81304 1 None -5 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)c1cccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
CHEMBL2158832 81304 1 None -5 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)c1cccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
71458869 82241 0 None -2 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 506 7 1 5 4.6 O=C(O)COc1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
CHEMBL2171022 82241 0 None -2 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 506 7 1 5 4.6 O=C(O)COc1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
71449857 82242 0 None -10 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 5 1 4 4.8 O=C(O)c1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171023 82242 0 None -10 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 5 1 4 4.8 O=C(O)c1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
71463287 84202 0 None -79 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 420 7 1 5 4.1 N#Cc1cccc(OC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
CHEMBL2208419 84202 0 None -79 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 420 7 1 5 4.1 N#Cc1cccc(OC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
59296085 84209 0 None -2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 506 8 2 7 3.1 CS(=O)(=O)c1ccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)s1 10.1016/j.bmcl.2012.09.113
CHEMBL2208426 84209 0 None -2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 506 8 2 7 3.1 CS(=O)(=O)c1ccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)s1 10.1016/j.bmcl.2012.09.113
71458870 82250 0 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 5 1 4 5.2 Cc1ccc(C(=O)N2CCC(N3CC[C@@H](Oc4ccc(Cl)c(C)c4Cl)C[C@H]3C(=O)O)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171031 82250 0 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 5 1 4 5.2 Cc1ccc(C(=O)N2CCC(N3CC[C@@H](Oc4ccc(Cl)c(C)c4Cl)C[C@H]3C(=O)O)CC2)cc1 10.1016/j.bmcl.2012.08.124
44389832 63924 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3ccnc4ccccc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL180621 63924 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3ccnc4ccccc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44391176 122611 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 385 1 1 4 4.9 Cc1sc2nc3n(c(=N)c2c1C)CC/C3=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL360268 122611 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 385 1 1 4 4.9 Cc1sc2nc3n(c(=N)c2c1C)CC/C3=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
57718837 116012 0 None -45 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 414 7 1 2 6.4 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355932 116012 0 None -45 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 414 7 1 2 6.4 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721189 116018 0 None -7 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 400 6 1 2 6.1 Cc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355938 116018 0 None -7 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 400 6 1 2 6.1 Cc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
11952524 116031 0 None -3 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 490 8 0 3 7.8 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccccc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355951 116031 0 None -3 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 490 8 0 3 7.8 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccccc1 10.1016/j.bmcl.2014.11.063
11952525 116038 0 None -21 3 Mouse 5.6 pKi = 5.6 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 562 10 0 5 8.0 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355958 116038 0 None -21 3 Mouse 5.6 pKi = 5.6 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 562 10 0 5 8.0 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)cc1 10.1016/j.bmcl.2014.11.063
118721201 116035 0 None 2 2 Rat 5.6 pKi = 5.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 548 10 1 4 7.6 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1Cc1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355955 116035 0 None 2 2 Rat 5.6 pKi = 5.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 548 10 1 4 7.6 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1Cc1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
44389688 64545 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 495 4 0 3 6.3 C[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL181460 64545 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 495 4 0 3 6.3 C[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44401117 70205 0 None - 1 Human 4.6 pKi = 4.6 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 413 7 1 3 4.2 Cc1ccc(CC(=O)NCC(c2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL194070 70205 0 None - 1 Human 4.6 pKi = 4.6 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 413 7 1 3 4.2 Cc1ccc(CC(=O)NCC(c2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
44391277 65786 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 369 1 1 4 4.4 Cc1oc2nc3n(c(=N)c2c1C)CC/C3=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL183478 65786 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 369 1 1 4 4.4 Cc1oc2nc3n(c(=N)c2c1C)CC/C3=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
118721205 116045 0 None -67 3 Mouse 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 653 11 3 5 7.2 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)O)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355965 116045 0 None -67 3 Mouse 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 653 11 3 5 7.2 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)O)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
44391236 123123 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 357 1 1 4 4.3 N=c1c2ccsc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL361149 123123 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 357 1 1 4 4.3 N=c1c2ccsc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
11360133 123320 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 351 1 1 3 4.2 N=c1c2ccccc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL361606 123320 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 351 1 1 3 4.2 N=c1c2ccccc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
44389704 62503 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 509 5 0 3 6.7 CC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL178136 62503 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 509 5 0 3 6.7 CC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44391252 65844 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 397 2 1 4 5.2 N=c1c2c(C3CC3)csc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL183520 65844 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 397 2 1 4 5.2 N=c1c2c(C3CC3)csc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
44391317 65502 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 336 2 0 2 5.7 C(=C1\CCN2Cc3ccccc3N=C12)\c1ccccc1-c1ccccc1 10.1016/j.bmcl.2004.11.039
CHEMBL183052 65502 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 336 2 0 2 5.7 C(=C1\CCN2Cc3ccccc3N=C12)\c1ccccc1-c1ccccc1 10.1016/j.bmcl.2004.11.039
44400990 166251 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 454 7 2 3 5.5 CC(C)CC(CNC(=O)Nc1cc(Cl)cc(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
CHEMBL426822 166251 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 454 7 2 3 5.5 CC(C)CC(CNC(=O)Nc1cc(Cl)cc(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
11466397 62879 0 None -407 4 Rat 5.5 pKi = 5.5 Binding
In vitro binding affinity against rat CC chemokine receptor 3In vitro binding affinity against rat CC chemokine receptor 3
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178447 62879 0 None -407 4 Rat 5.5 pKi = 5.5 Binding
In vitro binding affinity against rat CC chemokine receptor 3In vitro binding affinity against rat CC chemokine receptor 3
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
71451392 81274 0 None 31 2 Human 8.5 pKi = 8.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 C[C@](Cc1ccccc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158786 81274 0 None 31 2 Human 8.5 pKi = 8.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 C[C@](Cc1ccccc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
71458868 82232 0 None 6 2 Human 8.5 pKi = 8.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 568 6 1 6 4.8 Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)NS(=O)(=O)c4ccc(N(C)C)cc4)CC3)CC2)c1Cl 10.1016/j.bmcl.2012.08.124
CHEMBL2171014 82232 0 None 6 2 Human 8.5 pKi = 8.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 568 6 1 6 4.8 Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)NS(=O)(=O)c4ccc(N(C)C)cc4)CC3)CC2)c1Cl 10.1016/j.bmcl.2012.08.124
59295958 84012 0 None 1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 507 7 3 5 3.6 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccc(F)cc12 10.1016/j.bmcl.2012.09.112
CHEMBL2207280 84012 0 None 1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 507 7 3 5 3.6 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccc(F)cc12 10.1016/j.bmcl.2012.09.112
59296100 84088 0 None 7 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 460 7 3 5 3.0 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]nc2C(F)(F)F)CC1 10.1016/j.bmcl.2012.09.112
CHEMBL2207659 84088 0 None 7 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 460 7 3 5 3.0 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]nc2C(F)(F)F)CC1 10.1016/j.bmcl.2012.09.112
59296090 84092 0 None 1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 507 7 3 5 3.3 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)cc1C(F)(F)F 10.1016/j.bmcl.2012.09.112
CHEMBL2207662 84092 0 None 1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 507 7 3 5 3.3 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)cc1C(F)(F)F 10.1016/j.bmcl.2012.09.112
10653 2288 12 None - 1 Human 8.5 pKi = 8.5 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 511 6 1 5 3.6 O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C nan
59534386 2288 12 None - 1 Human 8.5 pKi = 8.5 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 511 6 1 5 3.6 O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C nan
CHEMBL3670800 2288 12 None - 1 Human 8.5 pKi = 8.5 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 511 6 1 5 3.6 O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C nan
DB15269 2288 12 None - 1 Human 8.5 pKi = 8.5 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 511 6 1 5 3.6 O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C nan
11466397 62879 0 None -1 4 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178447 62879 0 None -1 4 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
11466397 62879 0 None -1 4 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178447 62879 0 None -1 4 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
56966926 129279 0 None - 1 Human 8.5 pKi = 8.5 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 537 8 2 5 4.1 Cc1cc(C(=O)NCC2CC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670804 129279 0 None - 1 Human 8.5 pKi = 8.5 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 537 8 2 5 4.1 Cc1cc(C(=O)NCC2CC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
71072104 81263 0 None 15 2 Human 8.4 pKi = 8.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 520 9 1 5 5.3 COc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158775 81263 0 None 15 2 Human 8.4 pKi = 8.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 520 9 1 5 5.3 COc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
66615678 81268 0 None 19 2 Human 8.4 pKi = 8.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 488 8 1 4 5.0 Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158780 81268 0 None 19 2 Human 8.4 pKi = 8.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 488 8 1 4 5.0 Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
59296039 84210 0 None 15 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 467 8 3 6 3.2 COc1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)ccc1N 10.1016/j.bmcl.2012.09.113
CHEMBL2208427 84210 0 None 15 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 467 8 3 6 3.2 COc1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)ccc1N 10.1016/j.bmcl.2012.09.113
59295984 84011 0 None 3 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 487 7 3 5 3.3 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(F)ccc23)CC1 10.1016/j.bmcl.2012.09.112
CHEMBL2207279 84011 0 None 3 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 487 7 3 5 3.3 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(F)ccc23)CC1 10.1016/j.bmcl.2012.09.112
59296048 84016 0 None 6 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 582 9 4 7 2.4 CNS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
CHEMBL2207284 84016 0 None 6 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 582 9 4 7 2.4 CNS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
59295969 84017 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 608 10 4 7 2.9 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NC3CC3)ccc12 10.1016/j.bmcl.2012.09.112
CHEMBL2207285 84017 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 608 10 4 7 2.9 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NC3CC3)ccc12 10.1016/j.bmcl.2012.09.112
71454296 84095 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 521 7 2 6 3.3 Cn1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c(C(F)(F)F)cc1=O 10.1016/j.bmcl.2012.09.112
CHEMBL2207665 84095 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 521 7 2 6 3.3 Cn1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c(C(F)(F)F)cc1=O 10.1016/j.bmcl.2012.09.112
59296094 84099 0 None 31 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 480 7 3 6 2.7 N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1Cl 10.1016/j.bmcl.2012.09.112
CHEMBL2207669 84099 0 None 31 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 480 7 3 6 2.7 N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1Cl 10.1016/j.bmcl.2012.09.112
44389737 123862 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1ccc2ncccc2c1)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL362649 123862 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1ccc2ncccc2c1)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
66906657 116022 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355942 116022 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
68849581 81289 0 None 3 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 478 7 1 5 4.4 O=C(O)C(c1ccccc1)N1CCO[C@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2012.08.103
CHEMBL2158818 81289 0 None 3 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 478 7 1 5 4.4 O=C(O)C(c1ccccc1)N1CCO[C@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2012.08.103
69348078 81291 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)[C@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158820 81291 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)[C@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
69272932 81299 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 492 8 1 5 5.2 O=C(O)COc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158828 81299 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 492 8 1 5 5.2 O=C(O)COc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
71072034 81308 0 None 3 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 490 8 1 4 5.2 O=C(O)[C@@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158836 81308 0 None 3 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 490 8 1 4 5.2 O=C(O)[C@@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
17963208 82253 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 529 5 1 5 4.5 O=C(NS(=O)(=O)c1ccc(F)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171034 82253 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 529 5 1 5 4.5 O=C(NS(=O)(=O)c1ccc(F)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
71453505 82260 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 554 6 1 6 4.5 CN(C)c1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171041 82260 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 554 6 1 6 4.5 CN(C)c1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
17963347 82264 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 579 5 1 5 5.4 O=C(NS(=O)(=O)c1cccc(C(F)(F)F)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171045 82264 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 579 5 1 5 5.4 O=C(NS(=O)(=O)c1cccc(C(F)(F)F)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
71452601 84207 0 None -100 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 434 8 1 5 4.5 N#Cc1cccc(OC[C@@H](O)CCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
CHEMBL2208424 84207 0 None -100 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 434 8 1 5 4.5 N#Cc1cccc(OC[C@@H](O)CCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
59296098 84098 0 None 15 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 446 7 3 6 2.0 N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1 10.1016/j.bmcl.2012.09.112
CHEMBL2207668 84098 0 None 15 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 446 7 3 6 2.0 N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1 10.1016/j.bmcl.2012.09.112
44391213 122864 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 365 1 0 3 4.3 C/N=c1/c2ccccc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL360560 122864 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 365 1 0 3 4.3 C/N=c1/c2ccccc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
118721198 116028 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(C(N)=O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355948 116028 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(C(N)=O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44401177 68400 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 490 9 1 4 5.9 CN(C)c1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL191693 68400 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 490 9 1 4 5.9 CN(C)c1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401182 71069 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 476 7 2 3 6.0 Cc1cc(C)cc(NC(=O)NCC(CC(C)C)N2CCN(c3ccc(Cl)c(Cl)c3)CC2)c1 10.1021/jm040827u
CHEMBL195202 71069 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 476 7 2 3 6.0 Cc1cc(C)cc(NC(=O)NCC(CC(C)C)N2CCN(c3ccc(Cl)c(Cl)c3)CC2)c1 10.1021/jm040827u
25056325 71177 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 496 7 2 3 6.5 Cc1ccc(NC(=O)NCC(c2ccc(-c3ccccc3)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL195610 71177 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 496 7 2 3 6.5 Cc1ccc(NC(=O)NCC(c2ccc(-c3ccccc3)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
136229178 82244 0 None -19 2 Human 6.5 pKi = 6.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 516 5 1 6 4.5 O=C(c1ccc(-c2noc(=O)[nH]2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171025 82244 0 None -19 2 Human 6.5 pKi = 6.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 516 5 1 6 4.5 O=C(c1ccc(-c2noc(=O)[nH]2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
71452602 84219 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 433 8 2 5 3.9 N#Cc1cccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
CHEMBL2208436 84219 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 433 8 2 5 3.9 N#Cc1cccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
118721185 116014 0 None 1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355934 116014 0 None 1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721204 116044 0 None -28 3 Rat 6.5 pKi = 6.5 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 532 9 3 2 6.7 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)[nH]c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355964 116044 0 None -28 3 Rat 6.5 pKi = 6.5 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 532 9 3 2 6.7 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)[nH]c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
44391329 122340 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 344 2 0 3 4.9 FC(F)(F)Oc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
CHEMBL359918 122340 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 344 2 0 3 4.9 FC(F)(F)Oc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
11477767 63027 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL178818 63027 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44400948 71071 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 510 7 2 3 6.8 Cc1cc(C)cc(NC(=O)NCC(c2ccc(-c3ccccc3)cc2)N2CCN(C3CCCCC3)CC2)c1 10.1021/jm040827u
CHEMBL195214 71071 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 510 7 2 3 6.8 Cc1cc(C)cc(NC(=O)NCC(c2ccc(-c3ccccc3)cc2)N2CCN(C3CCCCC3)CC2)c1 10.1021/jm040827u
118721189 116018 0 None 1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 400 6 1 2 6.1 Cc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355938 116018 0 None 1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 400 6 1 2 6.1 Cc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44389738 64471 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 525 6 0 4 6.1 CCO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL181379 64471 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 525 6 0 4 6.1 CCO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
118721206 116046 0 None -97 3 Rat 5.5 pKi = 5.5 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 667 11 2 6 7.3 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)OC)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355966 116046 0 None -97 3 Rat 5.5 pKi = 5.5 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 667 11 2 6 7.3 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)OC)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
44389868 64639 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 588 7 1 5 4.9 CS(=O)(=O)NC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL181789 64639 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 588 7 1 5 4.9 CS(=O)(=O)NC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44401160 69465 0 None - 1 Human 5.5 pKi = 5.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 436 6 2 4 3.8 COc1ccccc1NC(=O)NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C)CC1 10.1021/jm040827u
CHEMBL193369 69465 0 None - 1 Human 5.5 pKi = 5.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 436 6 2 4 3.8 COc1ccccc1NC(=O)NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C)CC1 10.1021/jm040827u
118721206 116046 0 None 19 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 667 11 2 6 7.3 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)OC)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355966 116046 0 None 19 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 667 11 2 6 7.3 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)OC)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
44389784 64325 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3cnc4ccccc4n3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL181137 64325 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3cnc4ccccc4n3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44401083 124539 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.8 COc1ccccc1C(CNCCc1cc(Cl)cc(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
CHEMBL364047 124539 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.8 COc1ccccc1C(CNCCc1cc(Cl)cc(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
44401154 70264 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 477 9 1 4 5.8 COc1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL194161 70264 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 477 9 1 4 5.8 COc1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401031 70035 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 503 8 1 3 7.1 CC(C)(C)c1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL193973 70035 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 503 8 1 3 7.1 CC(C)(C)c1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401011 135240 0 None - 1 Human 4.5 pKi = 4.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 510 8 1 4 5.0 CN(C)c1ccc(C(CNC(=O)Cc2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL372493 135240 0 None - 1 Human 4.5 pKi = 4.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 510 8 1 4 5.0 CN(C)c1ccc(C(CNC(=O)Cc2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
44391247 123497 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 307 1 1 3 4.1 N=c1c2ccccc2nc2n1CC/C2=C\c1ccccc1Cl 10.1016/j.bmcl.2004.11.039
CHEMBL361761 123497 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 307 1 1 3 4.1 N=c1c2ccccc2nc2n1CC/C2=C\c1ccccc1Cl 10.1016/j.bmcl.2004.11.039
44389910 63356 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4cnccc4n3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL179490 63356 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4cnccc4n3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44391177 64469 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 411 1 1 4 5.2 N=c1c2c3c(sc2nc2n1CC/C2=C\c1ccccc1Br)CCCC3 10.1016/j.bmcl.2004.11.039
CHEMBL181367 64469 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 411 1 1 4 5.2 N=c1c2c3c(sc2nc2n1CC/C2=C\c1ccccc1Br)CCCC3 10.1016/j.bmcl.2004.11.039
44401206 127056 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 447 8 1 3 5.8 CC(C)(C)c1ccc(C(CNCCc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL365596 127056 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 447 8 1 3 5.8 CC(C)(C)c1ccc(C(CNCCc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
118721205 116045 0 None -870 3 Rat 5.5 pKi = 5.5 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 653 11 3 5 7.2 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)O)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355965 116045 0 None -870 3 Rat 5.5 pKi = 5.5 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 653 11 3 5 7.2 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)O)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
44401063 133099 0 None - 1 Human 5.5 pKi = 5.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 444 7 2 4 4.7 COc1ccccc1C(CNC(=O)Nc1ccc(C)cc1)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
CHEMBL370244 133099 0 None - 1 Human 5.5 pKi = 5.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 444 7 2 4 4.7 COc1ccccc1C(CNC(=O)Nc1ccc(C)cc1)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
44391192 63887 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 301 2 1 3 4.0 CCc1ccccc1/C=C1\CCn2c1nc1ccccc1c2=N 10.1016/j.bmcl.2004.11.039
CHEMBL180446 63887 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 301 2 1 3 4.0 CCc1ccccc1/C=C1\CCn2c1nc1ccccc1c2=N 10.1016/j.bmcl.2004.11.039
44401248 135987 0 None - 1 Human 5.4 pKi = 5.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.5 COc1ccccc1NC(=O)NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
CHEMBL373158 135987 0 None - 1 Human 5.4 pKi = 5.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.5 COc1ccccc1NC(=O)NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
118721189 116018 0 None -1 3 Mouse 7.4 pKi = 7.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 400 6 1 2 6.1 Cc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355938 116018 0 None -1 3 Mouse 7.4 pKi = 7.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 400 6 1 2 6.1 Cc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721196 116026 0 None -4 3 Mouse 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355946 116026 0 None -4 3 Mouse 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721197 116027 0 None -19 2 Rat 5.4 pKi = 5.4 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(OC)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355947 116027 0 None -19 2 Rat 5.4 pKi = 5.4 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(OC)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
57718829 116030 0 None 2 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 428 7 0 3 6.4 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1C 10.1016/j.bmcl.2014.11.063
CHEMBL3355950 116030 0 None 2 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 428 7 0 3 6.4 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1C 10.1016/j.bmcl.2014.11.063
44389752 64108 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1ccnc2ccccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL180813 64108 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1ccnc2ccccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
118721198 116028 0 None -1 2 Mouse 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(C(N)=O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355948 116028 0 None -1 2 Mouse 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(C(N)=O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44400950 68667 0 None - 1 Human 5.4 pKi = 5.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 449 6 2 4 4.2 CN1CCN(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(N(C)C)cc2)CC1 10.1021/jm040827u
CHEMBL192045 68667 0 None - 1 Human 5.4 pKi = 5.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 449 6 2 4 4.2 CN1CCN(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(N(C)C)cc2)CC1 10.1021/jm040827u
10151756 81286 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 462 6 1 4 5.1 O=C(O)C(c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158815 81286 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 462 6 1 4 5.1 O=C(O)C(c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
69274365 81297 1 None -7 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)Cc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
CHEMBL2158826 81297 1 None -7 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)Cc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
71449585 81300 0 None -7 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 492 8 1 5 5.2 O=C(O)COc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
CHEMBL2158829 81300 0 None -7 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 492 8 1 5 5.2 O=C(O)COc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
17963196 82255 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 541 6 1 6 4.4 COc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171036 82255 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 541 6 1 6 4.4 COc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
118721202 116042 0 None -77 3 Rat 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cc(C(=O)O)ccn1 10.1016/j.bmcl.2014.11.063
CHEMBL3355962 116042 0 None -77 3 Rat 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cc(C(=O)O)ccn1 10.1016/j.bmcl.2014.11.063
44391212 65843 0 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 303 2 1 4 3.5 COc1ccc(/C=C2\CCn3c2nc2ccccc2c3=N)cc1 10.1016/j.bmcl.2004.11.039
CHEMBL183519 65843 0 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 303 2 1 4 3.5 COc1ccc(/C=C2\CCn3c2nc2ccccc2c3=N)cc1 10.1016/j.bmcl.2004.11.039
44401088 166350 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 483 9 1 4 5.4 COc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL427357 166350 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 483 9 1 4 5.4 COc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
44389675 62861 0 None - 1 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 525 6 0 4 6.0 COC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL178438 62861 0 None - 1 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 525 6 0 4 6.0 COC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
71449859 82248 0 None -10 2 Human 6.4 pKi = 6.4 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 600 10 1 8 5.1 O=C(O)CCCCn1nnc(-c2ccc(C(=O)N3CCC(N4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)CC3)cc2)n1 10.1016/j.bmcl.2012.08.124
CHEMBL2171029 82248 0 None -10 2 Human 6.4 pKi = 6.4 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 600 10 1 8 5.1 O=C(O)CCCCn1nnc(-c2ccc(C(=O)N3CCC(N4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)CC3)cc2)n1 10.1016/j.bmcl.2012.08.124
71462391 82251 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 554 6 1 6 3.9 CS(=O)(=O)c1cccc(C(=O)N2CC[C@@H](N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)[C@H](C(=O)O)C2)c1 10.1016/j.bmcl.2012.08.124
CHEMBL2171032 82251 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 554 6 1 6 3.9 CS(=O)(=O)c1cccc(C(=O)N2CC[C@@H](N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)[C@H](C(=O)O)C2)c1 10.1016/j.bmcl.2012.08.124
118721205 116045 0 None 67 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 653 11 3 5 7.2 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)O)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355965 116045 0 None 67 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 653 11 3 5 7.2 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)O)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
67115149 129283 0 None - 1 Human 8.4 pKi = 8.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 8 2 5 4.5 CCC(C)NC(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
CHEMBL3670808 129283 0 None - 1 Human 8.4 pKi = 8.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 8 2 5 4.5 CCC(C)NC(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
68028908 129292 0 None - 1 Human 8.4 pKi = 8.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 7 1 5 4.5 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)cc(C(C)C)n3)CC2)ccc1Cl nan
CHEMBL3670817 129292 0 None - 1 Human 8.4 pKi = 8.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 7 1 5 4.5 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)cc(C(C)C)n3)CC2)ccc1Cl nan
68029259 129286 0 None - 1 Human 8.4 pKi = 8.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 537 7 2 5 4.2 Cc1cc(C(=O)NC2CCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670811 129286 0 None - 1 Human 8.4 pKi = 8.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 537 7 2 5 4.2 Cc1cc(C(=O)NC2CCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
118721191 116020 0 None 12 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 444 8 1 3 6.5 COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355940 116020 0 None 12 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 444 8 1 3 6.5 COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
67115103 129281 0 None - 1 Human 8.4 pKi = 8.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 8 2 5 4.3 Cc1cc(C(=O)NCC(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670806 129281 0 None - 1 Human 8.4 pKi = 8.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 8 2 5 4.3 Cc1cc(C(=O)NCC(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
56966996 129282 0 None - 1 Human 8.3 pKi = 8.3 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 547 8 2 5 3.9 Cc1cc(C(=O)NCC(F)F)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670807 129282 0 None - 1 Human 8.3 pKi = 8.3 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 547 8 2 5 3.9 Cc1cc(C(=O)NCC(F)F)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
118721200 116034 0 None 15 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 558 9 1 6 7.0 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(-c2nnn[nH]2)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355954 116034 0 None 15 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 558 9 1 6 7.0 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(-c2nnn[nH]2)cc1 10.1016/j.bmcl.2014.11.063
67115023 129276 0 None - 1 Human 8.3 pKi = 8.3 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 523 6 1 5 3.9 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N4CCCC4)ccn3)CC2)ccc1Cl nan
CHEMBL3670801 129276 0 None - 1 Human 8.3 pKi = 8.3 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 523 6 1 5 3.9 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N4CCCC4)ccn3)CC2)ccc1Cl nan
118721194 116024 0 None 5 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 426 8 1 3 6.4 COC(C)c1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355944 116024 0 None 5 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 426 8 1 3 6.4 COC(C)c1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
11952526 116033 0 None 24 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 534 9 1 4 7.5 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355953 116033 0 None 24 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 534 9 1 4 7.5 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
44389744 123873 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL362700 123873 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
66906657 116022 0 None -12 2 Mouse 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355942 116022 0 None -12 2 Mouse 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721199 116029 0 None -2 2 Human 5.4 pKi = 5.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 440 8 2 3 5.9 CCc1[nH]c2cc(C(=O)O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355949 116029 0 None -2 2 Human 5.4 pKi = 5.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 440 8 2 3 5.9 CCc1[nH]c2cc(C(=O)O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721188 116017 0 None -8 3 Rat 5.4 pKi = 5.4 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C(N)=O)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355937 116017 0 None -8 3 Rat 5.4 pKi = 5.4 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C(N)=O)cc2)CC1 10.1016/j.bmcl.2014.11.063
44401189 69843 0 None - 1 Human 4.4 pKi = 4.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 429 8 1 4 3.9 COc1ccc(C(CNC(=O)Cc2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL193818 69843 0 None - 1 Human 4.4 pKi = 4.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 429 8 1 4 3.9 COc1ccc(C(CNC(=O)Cc2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
44391800 64273 0 None - 1 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 484 6 0 3 4.9 COc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Br)cc3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL180939 64273 0 None - 1 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 484 6 0 3 4.9 COc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Br)cc3)CC2)CC1 10.1016/j.bmcl.2005.01.016
44389675 62861 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 525 6 0 4 6.0 COC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL178438 62861 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 525 6 0 4 6.0 COC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
25024850 116041 0 None -6 3 Mouse 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1cccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)n1 10.1016/j.bmcl.2014.11.063
CHEMBL3355961 116041 0 None -6 3 Mouse 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1cccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)n1 10.1016/j.bmcl.2014.11.063
68028909 129290 0 None - 1 Human 6.4 pKi = 6.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 553 9 1 5 4.7 CCCCc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670815 129290 0 None - 1 Human 6.4 pKi = 6.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 553 9 1 5 4.7 CCCCc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
118721195 116025 0 None -9 3 Rat 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(C)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355945 116025 0 None -9 3 Rat 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(C)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44400977 69956 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 420 7 2 3 4.8 CC(C)CC(CNC(=O)Nc1ccc(Cl)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
CHEMBL193916 69956 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 420 7 2 3 4.8 CC(C)CC(CNC(=O)Nc1ccc(Cl)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
44400944 70316 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 442 9 1 4 4.8 Cc1ccc(CCNCC(c2ccc(N(C)C)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL194435 70316 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 442 9 1 4 4.8 Cc1ccc(CCNCC(c2ccc(N(C)C)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
118721188 116017 0 None 2 3 Human 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C(N)=O)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355937 116017 0 None 2 3 Human 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C(N)=O)cc2)CC1 10.1016/j.bmcl.2014.11.063
44391312 65587 0 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 304 3 0 3 4.4 CCOc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
CHEMBL183229 65587 0 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 304 3 0 3 4.4 CCOc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
44389735 122324 0 None - 1 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1cnc2ccccc2c1)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL359850 122324 0 None - 1 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1cnc2ccccc2c1)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
118721195 116025 0 None 1 3 Human 7.3 pKi = 7.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(C)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355945 116025 0 None 1 3 Human 7.3 pKi = 7.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(C)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44389736 62836 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 513 5 0 3 6.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CF)C2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178422 62836 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 513 5 0 3 6.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CF)C2)CC1 10.1016/j.bmcl.2005.01.016
44389725 123655 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 482 4 0 4 5.5 O=C(c1cnnc2ccccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL362017 123655 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 482 4 0 4 5.5 O=C(c1cnnc2ccccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
56966927 129269 0 None - 1 Human 7.3 pKi = 7.3 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 456 6 1 5 3.6 COc1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
CHEMBL3670793 129269 0 None - 1 Human 7.3 pKi = 7.3 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 456 6 1 5 3.6 COc1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
118721193 116023 0 None -69 3 Rat 5.3 pKi = 5.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 398 7 2 3 5.2 OCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355943 116023 0 None -69 3 Rat 5.3 pKi = 5.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 398 7 2 3 5.2 OCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
11952525 116038 0 None -38 3 Rat 5.3 pKi = 5.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 562 10 0 5 8.0 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355958 116038 0 None -38 3 Rat 5.3 pKi = 5.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 562 10 0 5 8.0 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)cc1 10.1016/j.bmcl.2014.11.063
44401129 126777 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 391 7 1 3 3.8 CN1CCN(C(CNCCc2ccccc2)c2ccc(C(F)(F)F)cc2)CC1 10.1021/jm040827u
CHEMBL365369 126777 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 391 7 1 3 3.8 CN1CCN(C(CNCCc2ccccc2)c2ccc(C(F)(F)F)cc2)CC1 10.1021/jm040827u
44401175 127231 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.5 COc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL365806 127231 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.5 COc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401037 71080 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 474 6 2 3 5.5 O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1ccccc1 10.1021/jm040827u
CHEMBL195291 71080 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 474 6 2 3 5.5 O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1ccccc1 10.1021/jm040827u
118721195 116025 0 None -1 3 Mouse 7.3 pKi = 7.3 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(C)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355945 116025 0 None -1 3 Mouse 7.3 pKi = 7.3 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(C)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44389765 169336 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4nccnc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL441848 169336 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4nccnc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
118721192 116021 0 None -4 2 Human 6.3 pKi = 6.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 458 8 1 4 6.0 CCOC(=O)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355941 116021 0 None -4 2 Human 6.3 pKi = 6.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 458 8 1 4 6.0 CCOC(=O)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44401146 70261 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 459 8 1 3 5.5 FC(F)(F)c1ccc(C(CNCCc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL194135 70261 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 459 8 1 3 5.5 FC(F)(F)c1ccc(C(CNCCc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401256 71234 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 471 9 1 4 5.7 COc1ccccc1CCNCC(c1ccc(C(C)(C)C)cc1)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
CHEMBL195657 71234 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 471 9 1 4 5.7 COc1ccccc1CCNCC(c1ccc(C(C)(C)C)cc1)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
25024650 116040 0 None 21 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cccc(C(=O)O)n1 10.1016/j.bmcl.2014.11.063
CHEMBL3355960 116040 0 None 21 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cccc(C(=O)O)n1 10.1016/j.bmcl.2014.11.063
118721202 116042 0 None 15 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cc(C(=O)O)ccn1 10.1016/j.bmcl.2014.11.063
CHEMBL3355962 116042 0 None 15 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cc(C(=O)O)ccn1 10.1016/j.bmcl.2014.11.063
9914506 81257 0 None 3 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 515 8 1 5 5.1 N#Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158769 81257 0 None 3 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 515 8 1 5 5.1 N#Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
68938028 81260 0 None 6 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158772 81260 0 None 6 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
66615705 81267 0 None 19 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 508 8 1 4 5.4 O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3Cl)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158779 81267 0 None 19 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 508 8 1 4 5.4 O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3Cl)CC2)CC1 10.1016/j.bmcl.2012.08.103
69826668 82240 0 None 5 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 524 5 0 5 4.9 Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)c4cccc(S(C)(=O)=O)c4)CC3)CC2)c1Cl 10.1016/j.bmcl.2012.08.124
CHEMBL2171021 82240 0 None 5 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 524 5 0 5 4.9 Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)c4cccc(S(C)(=O)=O)c4)CC3)CC2)c1Cl 10.1016/j.bmcl.2012.08.124
71457010 82258 0 None 10 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 545 5 1 5 5.1 O=C(NS(=O)(=O)c1ccccc1Cl)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171039 82258 0 None 10 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 545 5 1 5 5.1 O=C(NS(=O)(=O)c1ccccc1Cl)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
70790202 129284 0 None - 1 Human 8.3 pKi = 8.3 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 553 8 1 5 4.8 CCC(C)N(C)C(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
CHEMBL3670809 129284 0 None - 1 Human 8.3 pKi = 8.3 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 553 8 1 5 4.8 CCC(C)N(C)C(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
57718837 116012 0 None 1 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 414 7 1 2 6.4 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355932 116012 0 None 1 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 414 7 1 2 6.4 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
56966997 129287 0 None - 1 Human 8.2 pKi = 8.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 555 6 1 5 3.8 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Br)c(C)c3)CC2)n1 nan
CHEMBL3670812 129287 0 None - 1 Human 8.2 pKi = 8.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 555 6 1 5 3.8 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Br)c(C)c3)CC2)n1 nan
11466397 62879 0 None -1 4 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178447 62879 0 None -1 4 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
10003872 70282 0 None - 1 Human 7.3 pKi = 7.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 449 9 1 4 5.1 COc1ccc(C(CNCCc2cc(C)cc(C)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL194283 70282 0 None - 1 Human 7.3 pKi = 7.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 449 9 1 4 5.1 COc1ccc(C(CNCCc2cc(C)cc(C)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
71451390 81266 0 None 7 2 Human 7.3 pKi = 7.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 474 8 1 4 4.7 O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158778 81266 0 None 7 2 Human 7.3 pKi = 7.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 474 8 1 4 4.7 O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2012.08.103
22397436 82237 0 None -6 2 Human 7.3 pKi = 7.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 510 5 0 5 4.5 CS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
CHEMBL2171019 82237 0 None -6 2 Human 7.3 pKi = 7.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 510 5 0 5 4.5 CS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
17963258 82256 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 554 6 1 6 4.5 CN(C)c1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171037 82256 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 554 6 1 6 4.5 CN(C)c1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
71451671 82247 0 None -31 2 Human 6.3 pKi = 6.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 519 8 2 5 5.0 O=C(O)CCNc1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171028 82247 0 None -31 2 Human 6.3 pKi = 6.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 519 8 2 5 5.0 O=C(O)CCNc1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
71451670 82235 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 455 7 1 4 4.2 COc1ccc(C(=O)NCCN2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)cc1Cl 10.1016/j.bmcl.2012.08.124
CHEMBL2171017 82235 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 455 7 1 4 4.2 COc1ccc(C(=O)NCCN2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)cc1Cl 10.1016/j.bmcl.2012.08.124
44389751 64644 0 None - 1 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 442 5 0 2 5.3 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(F)cc(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL181794 64644 0 None - 1 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 442 5 0 2 5.3 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(F)cc(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
44401136 70776 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 495 9 1 3 6.8 Cc1cc(C)cc(CCNCC(c2ccc(-c3ccccc3)cc2)N2CCN(C3CCCCC3)CC2)c1 10.1021/jm040827u
CHEMBL195081 70776 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 495 9 1 3 6.8 Cc1cc(C)cc(CCNCC(c2ccc(-c3ccccc3)cc2)N2CCN(C3CCCCC3)CC2)c1 10.1021/jm040827u
44401132 68636 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 474 5 2 3 5.1 CN1CCN(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(C(F)(F)F)cc2)CC1 10.1021/jm040827u
CHEMBL191824 68636 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 474 5 2 3 5.1 CN1CCN(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(C(F)(F)F)cc2)CC1 10.1021/jm040827u
118721191 116020 0 None -12 3 Mouse 7.3 pKi = 7.3 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 444 8 1 3 6.5 COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355940 116020 0 None -12 3 Mouse 7.3 pKi = 7.3 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 444 8 1 3 6.5 COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
25024849 116039 0 None -97 3 Rat 5.3 pKi = 5.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)nc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355959 116039 0 None -97 3 Rat 5.3 pKi = 5.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)nc1 10.1016/j.bmcl.2014.11.063
44401012 68670 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 454 7 2 4 4.6 COc1ccccc1C(CNC(=O)Nc1ccc(F)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
CHEMBL192066 68670 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 454 7 2 4 4.6 COc1ccccc1C(CNC(=O)Nc1ccc(F)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
44401145 70237 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 420 6 2 3 4.8 Cc1ccc(NC(=O)NCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL194086 70237 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 420 6 2 3 4.8 Cc1ccc(NC(=O)NCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
25024849 116039 0 None 13 3 Human 7.3 pKi = 7.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)nc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355959 116039 0 None 13 3 Human 7.3 pKi = 7.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)nc1 10.1016/j.bmcl.2014.11.063
44401048 69849 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 473 8 1 3 5.8 Cc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL193828 69849 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 473 8 1 3 5.8 Cc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
11952526 116033 0 None -1122 3 Rat 5.3 pKi = 5.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 534 9 1 4 7.5 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355953 116033 0 None -1122 3 Rat 5.3 pKi = 5.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 534 9 1 4 7.5 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
44401209 69804 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 418 6 2 3 4.5 O=C(NCC(c1ccccc1)N1CCN(c2ccccc2)CC1)Nc1ccc(F)cc1 10.1021/jm040827u
CHEMBL193592 69804 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 418 6 2 3 4.5 O=C(NCC(c1ccccc1)N1CCN(c2ccccc2)CC1)Nc1ccc(F)cc1 10.1021/jm040827u
44389683 131650 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)cc3Cl)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL369287 131650 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)cc3Cl)CC2)CC1 10.1016/j.bmcl.2005.01.016
118721196 116026 0 None -6 3 Rat 6.3 pKi = 6.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355946 116026 0 None -6 3 Rat 6.3 pKi = 6.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
24937215 116032 0 None -9 3 Rat 6.3 pKi = 6.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 472 9 1 4 5.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1CC(=O)O 10.1016/j.bmcl.2014.11.063
CHEMBL3355952 116032 0 None -9 3 Rat 6.3 pKi = 6.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 472 9 1 4 5.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1CC(=O)O 10.1016/j.bmcl.2014.11.063
44401226 71107 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 429 9 1 4 4.7 COc1ccc(C(CNCCc2ccc(C)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL195406 71107 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 429 9 1 4 4.7 COc1ccc(C(CNCCc2ccc(C)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
56966929 129275 0 None - 1 Human 8.2 pKi = 8.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 553 6 1 6 3.4 Cc1cc(C(=O)N2CCOCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670799 129275 0 None - 1 Human 8.2 pKi = 8.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 553 6 1 6 3.4 Cc1cc(C(=O)N2CCOCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
11753159 547 6 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2012.08.103
7679 547 6 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2012.08.103
CHEMBL2158814 547 6 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2012.08.103
11753159 547 6 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2012.08.124
7679 547 6 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2012.08.124
CHEMBL2158814 547 6 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2012.08.124
17963183 82262 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 545 5 1 5 5.1 O=C(NS(=O)(=O)c1cccc(Cl)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171043 82262 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 545 5 1 5 5.1 O=C(NS(=O)(=O)c1cccc(Cl)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
59296024 84009 0 None 9 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 547 8 3 7 2.5 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3ccc(S(C)(=O)=O)cc23)CC1 10.1016/j.bmcl.2012.09.112
CHEMBL2207277 84009 0 None 9 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 547 8 3 7 2.5 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3ccc(S(C)(=O)=O)cc23)CC1 10.1016/j.bmcl.2012.09.112
59296111 84087 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 480 7 3 5 3.4 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C(F)(F)F 10.1016/j.bmcl.2012.09.112
CHEMBL2207658 84087 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 480 7 3 5 3.4 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C(F)(F)F 10.1016/j.bmcl.2012.09.112
56966995 129280 0 None - 1 Human 8.2 pKi = 8.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 523 6 1 5 3.8 Cc1cc(C(=O)N2CCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670805 129280 0 None - 1 Human 8.2 pKi = 8.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 523 6 1 5 3.8 Cc1cc(C(=O)N2CCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
118721184 116013 0 None 1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccccc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355933 116013 0 None 1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccccc2)CC1 10.1016/j.bmcl.2014.11.063
25024850 116041 0 None 6 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1cccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)n1 10.1016/j.bmcl.2014.11.063
CHEMBL3355961 116041 0 None 6 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1cccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)n1 10.1016/j.bmcl.2014.11.063
44401005 70571 0 None - 1 Human 5.2 pKi = 5.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 459 9 1 5 3.9 COc1ccccc1CC(=O)NCC(c1ccccc1OC)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
CHEMBL194886 70571 0 None - 1 Human 5.2 pKi = 5.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 459 9 1 5 3.9 COc1ccccc1CC(=O)NCC(c1ccccc1OC)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
44401025 69677 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 496 9 1 4 5.5 CN(C)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL193535 69677 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 496 9 1 4 5.5 CN(C)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
11466397 62879 0 None -83 4 Mouse 6.2 pKi = 6.2 Binding
In vitro binding affinity against mouse CC chemokine receptor 3In vitro binding affinity against mouse CC chemokine receptor 3
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178447 62879 0 None -83 4 Mouse 6.2 pKi = 6.2 Binding
In vitro binding affinity against mouse CC chemokine receptor 3In vitro binding affinity against mouse CC chemokine receptor 3
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
24937215 116032 0 None 1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 472 9 1 4 5.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1CC(=O)O 10.1016/j.bmcl.2014.11.063
CHEMBL3355952 116032 0 None 1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 472 9 1 4 5.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1CC(=O)O 10.1016/j.bmcl.2014.11.063
70790203 129298 0 None - 1 Human 7.2 pKi = 7.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 525 6 1 5 4.0 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3cc(C)c(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670823 129298 0 None - 1 Human 7.2 pKi = 7.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 525 6 1 5 4.0 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3cc(C)c(Cl)c(C)c3)CC2)n1 nan
44391235 65245 0 None - 1 Human 5.2 pKi = 5.2 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 376 1 0 4 4.1 N#C/N=c1/c2ccccc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL182719 65245 0 None - 1 Human 5.2 pKi = 5.2 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 376 1 0 4 4.1 N#C/N=c1/c2ccccc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
118721185 116014 0 None -1 3 Mouse 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355934 116014 0 None -1 3 Mouse 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C)cc2)CC1 10.1016/j.bmcl.2014.11.063
25056323 71236 0 None - 1 Human 7.2 pKi = 7.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.8 COc1ccc(C(CNCCc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL195671 71236 0 None - 1 Human 7.2 pKi = 7.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.8 COc1ccc(C(CNCCc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401069 69110 0 None - 1 Human 4.2 pKi = 4.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 473 7 1 3 5.3 O=C(Cc1cc(Cl)cc(Cl)c1)NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
CHEMBL192384 69110 0 None - 1 Human 4.2 pKi = 4.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 473 7 1 3 5.3 O=C(Cc1cc(Cl)cc(Cl)c1)NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
44401110 68654 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 477 9 1 4 5.8 COc1ccc(C(CNCCc2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL191959 68654 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 477 9 1 4 5.8 COc1ccc(C(CNCCc2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
59296041 84100 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 558 8 3 8 2.1 CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(C#N)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
CHEMBL2207670 84100 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 558 8 3 8 2.1 CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(C#N)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
25024651 116036 0 None -39 3 Mouse 6.2 pKi = 6.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
CHEMBL3355956 116036 0 None -39 3 Mouse 6.2 pKi = 6.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
118721185 116014 0 None -19 3 Rat 6.2 pKi = 6.2 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355934 116014 0 None -19 3 Rat 6.2 pKi = 6.2 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C)cc2)CC1 10.1016/j.bmcl.2014.11.063
69347707 81305 1 None -5 2 Human 6.2 pKi = 6.2 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)c1ccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
CHEMBL2158833 81305 1 None -5 2 Human 6.2 pKi = 6.2 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)c1ccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
69260079 81306 2 None -63 2 Human 6.2 pKi = 6.2 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 463 6 1 5 4.8 O=C(O)c1cccnc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158834 81306 2 None -63 2 Human 6.2 pKi = 6.2 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 463 6 1 5 4.8 O=C(O)c1cccnc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
71457009 82249 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 5 1 4 5.2 Cc1ccc(C(=O)N2CCC(N3CC[C@H](Oc4ccc(Cl)c(C)c4Cl)C[C@@H]3C(=O)O)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171030 82249 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 5 1 4 5.2 Cc1ccc(C(=O)N2CCC(N3CC[C@H](Oc4ccc(Cl)c(C)c4Cl)C[C@@H]3C(=O)O)CC2)cc1 10.1016/j.bmcl.2012.08.124
17963199 82270 0 None 1 2 Human 6.2 pKi = 6.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 493 5 1 5 3.7 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(F)c(F)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171050 82270 0 None 1 2 Human 6.2 pKi = 6.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 493 5 1 5 3.7 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(F)c(F)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
44401203 70130 0 None - 1 Human 5.2 pKi = 5.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 424 6 2 3 4.6 O=C(NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(F)cc1 10.1021/jm040827u
CHEMBL194026 70130 0 None - 1 Human 5.2 pKi = 5.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 424 6 2 3 4.6 O=C(NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(F)cc1 10.1021/jm040827u
118721204 116044 0 None -5 3 Mouse 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 532 9 3 2 6.7 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)[nH]c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355964 116044 0 None -5 3 Mouse 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 532 9 3 2 6.7 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)[nH]c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
25024850 116041 0 None -107 3 Rat 5.2 pKi = 5.2 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1cccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)n1 10.1016/j.bmcl.2014.11.063
CHEMBL3355961 116041 0 None -107 3 Rat 5.2 pKi = 5.2 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1cccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)n1 10.1016/j.bmcl.2014.11.063
118721184 116013 0 None -1 3 Mouse 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccccc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355933 116013 0 None -1 3 Mouse 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccccc2)CC1 10.1016/j.bmcl.2014.11.063
11952524 116031 0 None -9 3 Mouse 6.2 pKi = 6.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 490 8 0 3 7.8 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccccc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355951 116031 0 None -9 3 Mouse 6.2 pKi = 6.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 490 8 0 3 7.8 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccccc1 10.1016/j.bmcl.2014.11.063
118721193 116023 0 None 1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 398 7 2 3 5.2 OCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355943 116023 0 None 1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 398 7 2 3 5.2 OCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44389684 62982 0 None - 1 Human 7.2 pKi = 7.2 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 468 5 0 2 5.2 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Br)cc3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178576 62982 0 None - 1 Human 7.2 pKi = 7.2 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 468 5 0 2 5.2 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Br)cc3)CC2)CC1 10.1016/j.bmcl.2005.01.016
118721206 116046 0 None -19 3 Mouse 6.2 pKi = 6.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 667 11 2 6 7.3 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)OC)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355966 116046 0 None -19 3 Mouse 6.2 pKi = 6.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 667 11 2 6 7.3 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)OC)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
11952524 116031 0 None 3 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 490 8 0 3 7.8 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccccc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355951 116031 0 None 3 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 490 8 0 3 7.8 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccccc1 10.1016/j.bmcl.2014.11.063
56966928 129270 0 None - 1 Human 7.2 pKi = 7.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 440 5 1 4 3.9 Cc1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
CHEMBL3670794 129270 0 None - 1 Human 7.2 pKi = 7.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 440 5 1 4 3.9 Cc1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
44389677 63088 0 None - 1 Human 7.2 pKi = 7.2 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1cccc2cccnc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178875 63088 0 None - 1 Human 7.2 pKi = 7.2 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1cccc2cccnc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
56965997 129268 0 None - 1 Human 7.2 pKi = 7.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 440 5 1 4 3.9 Cc1cccc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670792 129268 0 None - 1 Human 7.2 pKi = 7.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 440 5 1 4 3.9 Cc1cccc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
118721201 116035 0 None -2 2 Human 5.2 pKi = 5.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 548 10 1 4 7.6 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1Cc1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355955 116035 0 None -2 2 Human 5.2 pKi = 5.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 548 10 1 4 7.6 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1Cc1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
11466397 62879 0 None 1 4 Rhesus macaque 8.1 pKi = 8.1 Binding
In vitro binding affinity against monkey CC chemokine receptor 3In vitro binding affinity against monkey CC chemokine receptor 3
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178447 62879 0 None 1 4 Rhesus macaque 8.1 pKi = 8.1 Binding
In vitro binding affinity against monkey CC chemokine receptor 3In vitro binding affinity against monkey CC chemokine receptor 3
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
11477767 63027 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL178818 63027 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
67115945 129296 0 None - 1 Human 8.1 pKi = 8.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 525 7 1 5 3.9 CCc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)cc(C)n3)CC2)ccc1Cl nan
CHEMBL3670821 129296 0 None - 1 Human 8.1 pKi = 8.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 525 7 1 5 3.9 CCc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)cc(C)n3)CC2)ccc1Cl nan
56967065 129297 0 None - 1 Human 8.1 pKi = 8.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 521 6 1 5 3.3 C#Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670822 129297 0 None - 1 Human 8.1 pKi = 8.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 521 6 1 5 3.3 C#Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
71072052 81259 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 515 8 1 5 5.1 N#Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
CHEMBL2158771 81259 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 515 8 1 5 5.1 N#Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
71453204 81270 0 None 12 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 488 8 1 4 5.0 Cc1cc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl 10.1016/j.bmcl.2012.08.103
CHEMBL2158782 81270 0 None 12 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 488 8 1 4 5.0 Cc1cc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl 10.1016/j.bmcl.2012.08.103
17963363 82254 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 545 5 1 5 5.1 O=C(NS(=O)(=O)c1ccc(Cl)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171035 82254 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 545 5 1 5 5.1 O=C(NS(=O)(=O)c1ccc(Cl)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
17963226 82267 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 505 5 1 5 4.4 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4C)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171048 82267 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 505 5 1 5 4.4 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4C)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
59295994 84217 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 489 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cc(=O)[nH]c2ccccc12 10.1016/j.bmcl.2012.09.113
CHEMBL2208434 84217 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 489 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cc(=O)[nH]c2ccccc12 10.1016/j.bmcl.2012.09.113
59295925 84101 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 567 8 3 7 2.9 CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
CHEMBL2207671 84101 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 567 8 3 7 2.9 CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
56966999 129293 0 None - 1 Human 7.2 pKi = 7.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 495 6 1 5 3.1 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(F)c(C)c3)CC2)n1 nan
CHEMBL3670818 129293 0 None - 1 Human 7.2 pKi = 7.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 495 6 1 5 3.1 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(F)c(C)c3)CC2)n1 nan
118721200 116034 0 None -15 3 Mouse 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 558 9 1 6 7.0 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(-c2nnn[nH]2)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355954 116034 0 None -15 3 Mouse 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 558 9 1 6 7.0 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(-c2nnn[nH]2)cc1 10.1016/j.bmcl.2014.11.063
67115364 124437 0 None - 1 Human 7.1 pKi = 7.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 483 6 2 5 3.0 CNC(=O)c1cccc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3639696 124437 0 None - 1 Human 7.1 pKi = 7.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 483 6 2 5 3.0 CNC(=O)c1cccc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
44391319 64338 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 328 1 0 2 5.3 Clc1ccc(/C=C2\CCN3Cc4ccccc4N=C23)cc1Cl 10.1016/j.bmcl.2004.11.039
CHEMBL181195 64338 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 328 1 0 2 5.3 Clc1ccc(/C=C2\CCN3Cc4ccccc4N=C23)cc1Cl 10.1016/j.bmcl.2004.11.039
118721190 116019 0 None -40 3 Rat 6.1 pKi = 6.1 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 416 7 2 3 5.3 OCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355939 116019 0 None -40 3 Rat 6.1 pKi = 6.1 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 416 7 2 3 5.3 OCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
24937215 116032 0 None -1 3 Mouse 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 472 9 1 4 5.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1CC(=O)O 10.1016/j.bmcl.2014.11.063
CHEMBL3355952 116032 0 None -1 3 Mouse 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 472 9 1 4 5.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1CC(=O)O 10.1016/j.bmcl.2014.11.063
25024849 116039 0 None -13 3 Mouse 6.1 pKi = 6.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)nc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355959 116039 0 None -13 3 Mouse 6.1 pKi = 6.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)nc1 10.1016/j.bmcl.2014.11.063
44391170 65719 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 399 1 1 3 4.1 N=c1c2ccccc2nc2n1CC/C2=C\c1ccccc1I 10.1016/j.bmcl.2004.11.039
CHEMBL183461 65719 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 399 1 1 3 4.1 N=c1c2ccccc2nc2n1CC/C2=C\c1ccccc1I 10.1016/j.bmcl.2004.11.039
44400991 69813 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 471 9 1 4 5.7 COc1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL193633 69813 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 471 9 1 4 5.7 COc1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
43957010 68637 9 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 399 6 2 4 3.0 CN1CCN(C(CNC(=O)Nc2ccc(F)cc2)c2ccc(N(C)C)cc2)CC1 10.1021/jm040827u
CHEMBL191828 68637 9 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 399 6 2 4 3.0 CN1CCN(C(CNC(=O)Nc2ccc(F)cc2)c2ccc(N(C)C)cc2)CC1 10.1021/jm040827u
118721186 116015 0 None 2 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(O)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355935 116015 0 None 2 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(O)cc2)CC1 10.1016/j.bmcl.2014.11.063
44401085 135502 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 527 8 1 3 6.5 FC(F)(F)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL372858 135502 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 527 8 1 3 6.5 FC(F)(F)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
118721202 116042 0 None -15 3 Mouse 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cc(C(=O)O)ccn1 10.1016/j.bmcl.2014.11.063
CHEMBL3355962 116042 0 None -15 3 Mouse 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cc(C(=O)O)ccn1 10.1016/j.bmcl.2014.11.063
68846936 81287 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)C(c1ccccc1)N1CCCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2012.08.103
CHEMBL2158816 81287 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)C(c1ccccc1)N1CCCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2012.08.103
23102733 82233 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 511 6 1 5 4.0 O=C(NS(=O)(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1)c1ccccc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171015 82233 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 511 6 1 5 4.0 O=C(NS(=O)(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1)c1ccccc1 10.1016/j.bmcl.2012.08.124
71449858 82246 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 582 9 1 6 4.8 O=C(O)CCCS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
CHEMBL2171027 82246 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 582 9 1 6 4.8 O=C(O)CCCS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
71461541 84220 0 None 15 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 513 9 3 6 2.7 CS(=O)(=O)c1ccccc1C(=O)NCC(O)CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2012.09.113
CHEMBL2208437 84220 0 None 15 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 513 9 3 6 2.7 CS(=O)(=O)c1ccccc1C(=O)NCC(O)CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2012.09.113
44391240 123658 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 432 2 0 2 6.7 Fc1ccc(C2C/C(=C\c3ccccc3Br)C3=Nc4ccccc4CN32)cc1 10.1016/j.bmcl.2004.11.039
CHEMBL362032 123658 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 432 2 0 2 6.7 Fc1ccc(C2C/C(=C\c3ccccc3Br)C3=Nc4ccccc4CN32)cc1 10.1016/j.bmcl.2004.11.039
44389732 64348 0 None - 1 Human 6.1 pKi = 6.1 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 420 6 0 3 4.5 COc1ccc(CC2CCN(C3CCN(C(=O)Cc4ccccc4C)CC3)CC2)cc1 10.1016/j.bmcl.2005.01.016
CHEMBL181230 64348 0 None - 1 Human 6.1 pKi = 6.1 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 420 6 0 3 4.5 COc1ccc(CC2CCN(C3CCN(C(=O)Cc4ccccc4C)CC3)CC2)cc1 10.1016/j.bmcl.2005.01.016
71450777 84203 0 None -63 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 404 7 0 4 5.2 N#Cc1cccc(OCCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
CHEMBL2208420 84203 0 None -63 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 404 7 0 4 5.2 N#Cc1cccc(OCCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
56965994 129288 0 None - 1 Human 8.1 pKi = 8.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 525 7 1 5 3.9 CCc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670813 129288 0 None - 1 Human 8.1 pKi = 8.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 525 7 1 5 3.9 CCc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
56965996 129273 0 None - 1 Human 8.1 pKi = 8.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 497 6 1 5 3.3 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)ccn3)CC2)ccc1Cl nan
CHEMBL3670797 129273 0 None - 1 Human 8.1 pKi = 8.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 497 6 1 5 3.3 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)ccn3)CC2)ccc1Cl nan
25056324 126945 0 None - 1 Human 7.1 pKi = 7.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 459 8 1 3 5.8 Clc1cc(Cl)cc(CCNCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)c1 10.1021/jm040827u
CHEMBL365551 126945 0 None - 1 Human 7.1 pKi = 7.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 459 8 1 3 5.8 Clc1cc(Cl)cc(CCNCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)c1 10.1021/jm040827u
44401070 69111 0 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 414 6 2 3 4.7 Cc1ccc(NC(=O)NCC(c2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL192385 69111 0 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 414 6 2 3 4.7 Cc1ccc(NC(=O)NCC(c2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
24937092 116037 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 500 10 0 5 6.4 CCOC(=O)Cn1c(CC)c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc21 10.1016/j.bmcl.2014.11.063
CHEMBL3355957 116037 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 500 10 0 5 6.4 CCOC(=O)Cn1c(CC)c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc21 10.1016/j.bmcl.2014.11.063
44391282 122621 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 352 1 1 4 3.6 N=c1c2cccnc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL360308 122621 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 352 1 1 4 3.6 N=c1c2cccnc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
136216709 78966 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 341 1 2 4 2.9 N=c1c2nc[nH]c2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL2113024 78966 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 341 1 2 4 2.9 N=c1c2nc[nH]c2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
44387847 60495 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.8 COc1ccc(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL175547 60495 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.8 COc1ccc(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44387853 63445 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 515 8 1 3 6.8 CC(C)(C)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL179752 63445 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 515 8 1 3 6.8 CC(C)(C)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
57718829 116030 0 None -2 2 Mouse 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 428 7 0 3 6.4 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1C 10.1016/j.bmcl.2014.11.063
CHEMBL3355950 116030 0 None -2 2 Mouse 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 428 7 0 3 6.4 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1C 10.1016/j.bmcl.2014.11.063
118721196 116026 0 None 4 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355946 116026 0 None 4 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44389790 64772 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3cnnc4ccccc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL181929 64772 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3cnnc4ccccc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
56967063 129294 0 None - 1 Human 7.1 pKi = 7.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 565 6 1 5 4.4 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C(F)(F)F)c3)CC2)n1 nan
CHEMBL3670819 129294 0 None - 1 Human 7.1 pKi = 7.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 565 6 1 5 4.4 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C(F)(F)F)c3)CC2)n1 nan
118721184 116013 0 None -14 3 Rat 6.1 pKi = 6.1 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccccc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355933 116013 0 None -14 3 Rat 6.1 pKi = 6.1 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccccc2)CC1 10.1016/j.bmcl.2014.11.063
44400974 135290 0 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 485 8 1 4 5.2 COc1ccccc1CC(=O)NCC(c1ccc(C(C)(C)C)cc1)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
CHEMBL372725 135290 0 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 485 8 1 4 5.2 COc1ccccc1CC(=O)NCC(c1ccc(C(C)(C)C)cc1)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
44400949 69156 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 477 8 1 3 5.7 Fc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL192412 69156 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 477 8 1 3 5.7 Fc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401155 70173 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.8 COc1ccccc1C(CNC(=O)Nc1cc(Cl)cc(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
CHEMBL194044 70173 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.8 COc1ccccc1C(CNC(=O)Nc1cc(Cl)cc(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
44401094 71129 0 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 391 7 1 3 3.8 CN1CCN(C(CNCCc2ccc(C(F)(F)F)cc2)c2ccccc2)CC1 10.1021/jm040827u
CHEMBL195488 71129 0 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 391 7 1 3 3.8 CN1CCN(C(CNCCc2ccc(C(F)(F)F)cc2)c2ccccc2)CC1 10.1021/jm040827u
11397231 81463 0 None - 1 Human 8.1 pKi = 8.1 Binding
Inhibition of CCR3 receptorInhibition of CCR3 receptor
ChEMBL 469 7 0 4 6.2 Fc1ccc(SCCCN2CCC(n3c(CC(F)(F)F)nc4cc(F)ccc43)CC2)cc1 10.1016/j.bmc.2012.09.013
CHEMBL2159766 81463 0 None - 1 Human 8.1 pKi = 8.1 Binding
Inhibition of CCR3 receptorInhibition of CCR3 receptor
ChEMBL 469 7 0 4 6.2 Fc1ccc(SCCCN2CCC(n3c(CC(F)(F)F)nc4cc(F)ccc43)CC2)cc1 10.1016/j.bmc.2012.09.013
9797962 65674 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 338 1 0 2 4.8 Brc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
CHEMBL183429 65674 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 338 1 0 2 4.8 Brc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
44401032 70128 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 492 7 2 4 5.8 COc1ccc(C(CNC(=O)Nc2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL194022 70128 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 492 7 2 4 5.8 COc1ccc(C(CNC(=O)Nc2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401234 69841 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 435 9 1 4 4.8 COc1ccc(C(CNCCc2ccc(C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL193809 69841 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 435 9 1 4 4.8 COc1ccc(C(CNCCc2ccc(C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
118721193 116023 0 None -1 3 Mouse 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 398 7 2 3 5.2 OCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355943 116023 0 None -1 3 Mouse 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 398 7 2 3 5.2 OCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44401089 124059 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.5 COc1ccc(C(CNCCc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL363181 124059 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.5 COc1ccc(C(CNCCc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44391268 63899 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 312 1 0 2 4.8 Fc1ccc(/C=C2\CCN3Cc4ccccc4N=C23)c(Cl)c1 10.1016/j.bmcl.2004.11.039
CHEMBL180493 63899 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 312 1 0 2 4.8 Fc1ccc(/C=C2\CCN3Cc4ccccc4N=C23)c(Cl)c1 10.1016/j.bmcl.2004.11.039
44387857 61034 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 542 6 2 3 6.8 O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1cc(Cl)cc(Cl)c1 10.1021/jm040827u
CHEMBL176281 61034 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 542 6 2 3 6.8 O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1cc(Cl)cc(Cl)c1 10.1021/jm040827u
44389729 64349 0 None - 1 Human 6.0 pKi = 6.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(Cl)cc(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL181232 64349 0 None - 1 Human 6.0 pKi = 6.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(Cl)cc(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
118721187 116016 0 None -10 3 Rat 6.0 pKi = 6.0 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(OC)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355936 116016 0 None -10 3 Rat 6.0 pKi = 6.0 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(OC)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721187 116016 0 None 1 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(OC)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355936 116016 0 None 1 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(OC)cc2)CC1 10.1016/j.bmcl.2014.11.063
44400978 135876 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 530 6 2 3 6.8 CC(C)(C)c1ccc(C(CNC(=O)Nc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL373092 135876 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 530 6 2 3 6.8 CC(C)(C)c1ccc(C(CNC(=O)Nc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
118721203 116043 0 None 1 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccnc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355963 116043 0 None 1 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccnc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)c1 10.1016/j.bmcl.2014.11.063
44400983 71138 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 436 7 2 4 4.5 COc1ccc(NC(=O)NCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL195533 71138 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 436 7 2 4 4.5 COc1ccc(NC(=O)NCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401176 68401 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 517 7 2 4 5.9 CN(C)c1ccc(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL191696 68401 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 517 7 2 4 5.9 CN(C)c1ccc(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
118721190 116019 0 None -5 3 Human 7.0 pKi = 7 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 416 7 2 3 5.3 OCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355939 116019 0 None -5 3 Human 7.0 pKi = 7 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 416 7 2 3 5.3 OCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721203 116043 0 None -10 3 Rat 6.0 pKi = 6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccnc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355963 116043 0 None -10 3 Rat 6.0 pKi = 6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccnc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)c1 10.1016/j.bmcl.2014.11.063
795 574 5 None - 1 Human 8.3 pKd None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 12450563
796 574 5 None - 1 Human 8.3 pKd None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 12450563
9913085 574 5 None - 1 Human 8.3 pKd None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 12450563
CHEMBL20921 574 5 None - 1 Human 8.3 pKd None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 12450563
11753159 547 6 None 1 2 Human 8.2 pKi = 8.2 Binding
Assay using sodium salt of the compoundAssay using sodium salt of the compound
Guide to Pharmacology 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 23031591
7679 547 6 None 1 2 Human 8.2 pKi = 8.2 Binding
Assay using sodium salt of the compoundAssay using sodium salt of the compound
Guide to Pharmacology 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 23031591
CHEMBL2158814 547 6 None 1 2 Human 8.2 pKi = 8.2 Binding
Assay using sodium salt of the compoundAssay using sodium salt of the compound
Guide to Pharmacology 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 23031591
10653 2288 12 None - 1 Human 8.5 pKi = 8.5 Binding
Dissociation constant determined in a scintillation proximity binding assay using recombinant human [<sup>125</sup>]l-eotaxin-1 as radioligand and cell membranes prepared from K562 cells transfected with hCCR3.Dissociation constant determined in a scintillation proximity binding assay using recombinant human [<sup>125</sup>]l-eotaxin-1 as radioligand and cell membranes prepared from K562 cells transfected with hCCR3.
Guide to Pharmacology 511 6 1 5 3.6 O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C None
59534386 2288 12 None - 1 Human 8.5 pKi = 8.5 Binding
Dissociation constant determined in a scintillation proximity binding assay using recombinant human [<sup>125</sup>]l-eotaxin-1 as radioligand and cell membranes prepared from K562 cells transfected with hCCR3.Dissociation constant determined in a scintillation proximity binding assay using recombinant human [<sup>125</sup>]l-eotaxin-1 as radioligand and cell membranes prepared from K562 cells transfected with hCCR3.
Guide to Pharmacology 511 6 1 5 3.6 O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C None
CHEMBL3670800 2288 12 None - 1 Human 8.5 pKi = 8.5 Binding
Dissociation constant determined in a scintillation proximity binding assay using recombinant human [<sup>125</sup>]l-eotaxin-1 as radioligand and cell membranes prepared from K562 cells transfected with hCCR3.Dissociation constant determined in a scintillation proximity binding assay using recombinant human [<sup>125</sup>]l-eotaxin-1 as radioligand and cell membranes prepared from K562 cells transfected with hCCR3.
Guide to Pharmacology 511 6 1 5 3.6 O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C None
DB15269 2288 12 None - 1 Human 8.5 pKi = 8.5 Binding
Dissociation constant determined in a scintillation proximity binding assay using recombinant human [<sup>125</sup>]l-eotaxin-1 as radioligand and cell membranes prepared from K562 cells transfected with hCCR3.Dissociation constant determined in a scintillation proximity binding assay using recombinant human [<sup>125</sup>]l-eotaxin-1 as radioligand and cell membranes prepared from K562 cells transfected with hCCR3.
Guide to Pharmacology 511 6 1 5 3.6 O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C None
3492 692 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 12067561
9868459 692 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 12067561
CHEMBL50593 692 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 12067561
3530 3518 0 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 378 6 1 5 3.3 COC(=O)[C@@H](NC(=O)c1ccc2c(c1)cccc2)Cc1ccc(cc1)N(=O)=O None
5311092 3518 0 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 378 6 1 5 3.3 COC(=O)[C@@H](NC(=O)c1ccc2c(c1)cccc2)Cc1ccc(cc1)N(=O)=O None
795 574 5 None - 1 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 12450563
796 574 5 None - 1 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 12450563
9913085 574 5 None - 1 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 12450563
CHEMBL20921 574 5 None - 1 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 12450563
758 865 0 None -3 4 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8642344
759 866 0 None 6 4 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8642344
787 826 0 None - 1 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8642344
769 827 0 None 446 2 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8642344
771 838 0 None 1 2 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8642344