Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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name		 GPCRdb
ID		 #Vendors

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ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
11272103 131153 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
CHEMBL363840 131153 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
11272103 131153 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.087
CHEMBL363840 131153 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.087
11272103 131153 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil at 30 nMAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil at 30 nM
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.087
CHEMBL363840 131153 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil at 30 nMAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil at 30 nM
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.087
11272103 131153 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL363840 131153 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
11272103 131153 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL363840 131153 0 None -37 8 Human 11.0 pIC50 = 11 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
44455820 102217 0 None - 1 Human 11.0 pIC50 = 11.0 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 551 11 3 7 4.9 CCC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL257074 102217 0 None - 1 Human 11.0 pIC50 = 11.0 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 551 11 3 7 4.9 CCC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 10.1016/j.bmcl.2007.11.067
10458976 101786 0 None - 1 Human 10.9 pIC50 = 10.9 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 509 9 3 7 3.4 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254930 101786 0 None - 1 Human 10.9 pIC50 = 10.9 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 509 9 3 7 3.4 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44455711 175512 0 None - 1 Human 10.9 pIC50 = 10.9 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 509 9 3 7 3.8 CCc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL437031 175512 0 None - 1 Human 10.9 pIC50 = 10.9 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 509 9 3 7 3.8 CCc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11340670 134012 0 None - 1 Human 10.8 pIC50 = 10.8 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 483 7 2 3 5.8 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F 10.1021/jm049530m
CHEMBL365820 134012 0 None - 1 Human 10.8 pIC50 = 10.8 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 483 7 2 3 5.8 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F 10.1021/jm049530m
11328714 85773 0 None - 1 Human 10.8 pIC50 = 10.8 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113074 85773 0 None - 1 Human 10.8 pIC50 = 10.8 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44455686 102267 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 523 9 3 7 4.3 CC(C)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL257293 102267 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 523 9 3 7 4.3 CC(C)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455869 104321 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 507 9 2 7 4.1 CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL270582 104321 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 507 9 2 7 4.1 CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455509 173205 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 493 9 2 6 4.4 CCc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL427728 173205 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 493 9 2 6 4.4 CCc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455485 162277 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 507 9 2 6 5.0 CC(C)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL404122 162277 0 None - 1 Human 10.7 pIC50 = 10.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 507 9 2 6 5.0 CC(C)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11329244 77891 11 None 20 7 Human 10.5 pIC50 = 10.5 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL195433 77891 11 None 20 7 Human 10.5 pIC50 = 10.5 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
11329244 77891 11 None 20 7 Human 10.5 pIC50 = 10.5 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
CHEMBL195433 77891 11 None 20 7 Human 10.5 pIC50 = 10.5 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
11227406 101120 2 None 107 4 Human 10.5 pIC50 = 10.5 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
CHEMBL250689 101120 2 None 107 4 Human 10.5 pIC50 = 10.5 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
11227406 101120 2 None 107 4 Human 10.5 pIC50 = 10.5 Functional
Antagonist activity at CCR3 assessed as inhibition of chemotaxis by cell based assayAntagonist activity at CCR3 assessed as inhibition of chemotaxis by cell based assay
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm300682j
CHEMBL250689 101120 2 None 107 4 Human 10.5 pIC50 = 10.5 Functional
Antagonist activity at CCR3 assessed as inhibition of chemotaxis by cell based assayAntagonist activity at CCR3 assessed as inhibition of chemotaxis by cell based assay
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm300682j
11227406 101120 2 None 107 4 Human 10.5 pIC50 = 10.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL250689 101120 2 None 107 4 Human 10.5 pIC50 = 10.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
11227406 101120 2 None 107 4 Human 10.5 pIC50 = 10.5 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL250689 101120 2 None 107 4 Human 10.5 pIC50 = 10.5 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
10050884 161431 14 None -1 3 Human 10.4 pIC50 = 10.4 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.087
CHEMBL399495 161431 14 None -1 3 Human 10.4 pIC50 = 10.4 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.087
11227406 101120 2 None 107 4 Human 10.4 pIC50 = 10.4 Functional
Inhibition of eotaxin-induced chemotaxis of Cynomolgus monkey eosinophilsInhibition of eotaxin-induced chemotaxis of Cynomolgus monkey eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL250689 101120 2 None 107 4 Human 10.4 pIC50 = 10.4 Functional
Inhibition of eotaxin-induced chemotaxis of Cynomolgus monkey eosinophilsInhibition of eotaxin-induced chemotaxis of Cynomolgus monkey eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
10050884 161431 14 None -1 3 Human 10.4 pIC50 = 10.4 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
CHEMBL399495 161431 14 None -1 3 Human 10.4 pIC50 = 10.4 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
11169258 147675 0 None - 1 Human 10.4 pIC50 = 10.4 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 587 8 2 10 3.8 Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1021/jm049530m
CHEMBL382108 147675 0 None - 1 Human 10.4 pIC50 = 10.4 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 587 8 2 10 3.8 Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1021/jm049530m
11488078 85776 0 None - 1 Human 10.4 pIC50 = 10.4 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113077 85776 0 None - 1 Human 10.4 pIC50 = 10.4 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44455683 161867 0 None - 1 Human 10.3 pIC50 = 10.3 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 531 9 3 7 4.4 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL401879 161867 0 None - 1 Human 10.3 pIC50 = 10.3 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 531 9 3 7 4.4 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
44455745 162080 0 None - 1 Human 10.3 pIC50 = 10.3 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 559 8 3 7 4.0 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(Br)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL402983 162080 0 None - 1 Human 10.3 pIC50 = 10.3 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 559 8 3 7 4.0 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(Br)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455793 102002 0 None - 1 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 483 9 3 5 4.4 CC(=O)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL256068 102002 0 None - 1 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 483 9 3 5 4.4 CC(=O)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
11397114 140247 0 None - 1 Human 10.2 pIC50 = 10.2 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2cn[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL3706810 140247 0 None - 1 Human 10.2 pIC50 = 10.2 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2cn[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44455766 102460 0 None - 1 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 479 8 2 6 4.3 C[C@H](C[C@@H](C)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL258156 102460 0 None - 1 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 479 8 2 6 4.3 C[C@H](C[C@@H](C)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11953409 100991 0 None 7 4 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249854 100991 0 None 7 4 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445847 101199 0 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 487 7 3 6 3.8 CC(=O)c1sc(NC(=O)N[C@@H]2CNCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251079 101199 0 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 487 7 3 6 3.8 CC(=O)c1sc(NC(=O)N[C@@H]2CNCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
11214474 78128 0 None - 1 Human 10.1 pIC50 = 10.1 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 514 6 2 4 6.7 O=C(Nc1nc2c(Cl)cccc2s1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL195790 78128 0 None - 1 Human 10.1 pIC50 = 10.1 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 514 6 2 4 6.7 O=C(Nc1nc2c(Cl)cccc2s1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44445845 101017 0 None - 1 Human 10.0 pIC50 = 10 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 487 7 3 6 3.8 CC(=O)c1sc(NC(=O)N[C@@H]2CCNC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL250056 101017 0 None - 1 Human 10.0 pIC50 = 10 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 487 7 3 6 3.8 CC(=O)c1sc(NC(=O)N[C@@H]2CCNC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455845 104235 0 None - 1 Human 10.0 pIC50 = 10 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 537 10 3 7 4.5 CC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL270146 104235 0 None - 1 Human 10.0 pIC50 = 10 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 537 10 3 7 4.5 CC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 10.1016/j.bmcl.2007.11.067
44455846 104236 0 None - 1 Human 10.0 pIC50 = 10 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 515 9 2 6 5.1 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL270147 104236 0 None - 1 Human 10.0 pIC50 = 10 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 515 9 2 6 5.1 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
44455458 174236 0 None - 1 Human 10.0 pIC50 = 10 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 533 9 3 7 5.3 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2ccon2)cc(-c2ccon2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL429846 174236 0 None - 1 Human 10.0 pIC50 = 10 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 533 9 3 7 5.3 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2ccon2)cc(-c2ccon2)c1 10.1016/j.bmcl.2007.11.067
11454941 77917 0 None - 1 Human 10.0 pIC50 = 10 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 505 7 2 6 4.7 Cc1nnnn1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL195555 77917 0 None - 1 Human 10.0 pIC50 = 10 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 505 7 2 6 4.7 Cc1nnnn1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
10050884 161431 14 None 1 3 Crab-eating macaque 9.8 pIC50 = 9.8 Functional
Antagonist activity at CCR3 receptor in cynomolgus monkey eosinophil assessed as as inhibition of chemotaxisAntagonist activity at CCR3 receptor in cynomolgus monkey eosinophil assessed as as inhibition of chemotaxis
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
CHEMBL399495 161431 14 None 1 3 Crab-eating macaque 9.8 pIC50 = 9.8 Functional
Antagonist activity at CCR3 receptor in cynomolgus monkey eosinophil assessed as as inhibition of chemotaxisAntagonist activity at CCR3 receptor in cynomolgus monkey eosinophil assessed as as inhibition of chemotaxis
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
44455459 101866 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 467 9 2 4 5.1 CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL255398 101866 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 467 9 2 4 5.1 CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
10140602 173397 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 479 7 2 6 3.4 C[C@H](CC(=O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL428071 173397 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 479 7 2 6 3.4 C[C@H](CC(=O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11398022 105407 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 10.1021/jm049530m
CHEMBL277131 105407 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 10.1021/jm049530m
44455484 174185 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 493 9 2 6 4.6 CC(C)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL429604 174185 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 493 9 2 6 4.6 CC(C)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455483 104605 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 537 10 3 7 3.8 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)(C)C(=O)O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL272068 104605 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 537 10 3 7 3.8 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)(C)C(=O)O)c1 10.1016/j.bmcl.2007.11.067
11385766 139574 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL370082 139574 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
11236950 101539 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 479 9 2 6 4.3 CN(CCCc1ccc(F)cc1)C[C@@H]1CCCC[C@H]1NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL253210 101539 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 479 9 2 6 4.3 CN(CCCc1ccc(F)cc1)C[C@@H]1CCCC[C@H]1NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
71460523 88269 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at CCR3 receptor in human eosinophils assessed as inhibition of CCL11-induced degranulation after 4 hrs by ELISAAntagonist activity at CCR3 receptor in human eosinophils assessed as inhibition of CCL11-induced degranulation after 4 hrs by ELISA
ChEMBL 423 7 3 4 3.7 O=C(Nc1ccccc1OCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160099 88269 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at CCR3 receptor in human eosinophils assessed as inhibition of CCL11-induced degranulation after 4 hrs by ELISAAntagonist activity at CCR3 receptor in human eosinophils assessed as inhibition of CCL11-induced degranulation after 4 hrs by ELISA
ChEMBL 423 7 3 4 3.7 O=C(Nc1ccccc1OCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
44455817 161957 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 538 9 3 8 3.6 CNC(=O)O[C@H](C[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)N1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
CHEMBL402331 161957 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 538 9 3 8 3.6 CNC(=O)O[C@H](C[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)N1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
10050884 161431 14 None -1 3 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-stimulated intracellular calcium fluxAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-stimulated intracellular calcium flux
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
CHEMBL399495 161431 14 None -1 3 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-stimulated intracellular calcium fluxAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-stimulated intracellular calcium flux
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
44445854 100858 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 522 7 2 7 3.3 CC(=O)c1sc(NC(=O)N[C@@H]2CS(=O)(=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249057 100858 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in human eosinophils
ChEMBL 522 7 2 7 3.3 CC(=O)c1sc(NC(=O)N[C@@H]2CS(=O)(=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
45267588 202813 0 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 501 5 2 4 4.5 Cc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c(O)c1 10.1016/j.bmc.2009.06.066
CHEMBL560275 202813 0 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 501 5 2 4 4.5 Cc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c(O)c1 10.1016/j.bmc.2009.06.066
44512617 202117 0 None 79 2 Human 9.0 pIC50 = 9 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells by functional inhibition curve analysisAntagonist activity at human CCR3 expressed in mouse B300-19 cells by functional inhibition curve analysis
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL551735 202117 0 None 79 2 Human 9.0 pIC50 = 9 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells by functional inhibition curve analysisAntagonist activity at human CCR3 expressed in mouse B300-19 cells by functional inhibition curve analysis
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
44455658 174052 0 None - 1 Human 9.0 pIC50 = 9 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 479 8 3 5 4.4 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nccn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL429323 174052 0 None - 1 Human 9.0 pIC50 = 9 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 479 8 3 5 4.4 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nccn2C)c1 10.1016/j.bmcl.2007.11.067
44289715 177014 0 None - 1 Human 9.0 pIC50 = 9 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 465 8 2 6 3.8 Cc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL444568 177014 0 None - 1 Human 9.0 pIC50 = 9 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 465 8 2 6 3.8 Cc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11272103 131153 0 None -37 8 Human 9.0 pIC50 = 9 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL363840 131153 0 None -37 8 Human 9.0 pIC50 = 9 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
11363006 77210 0 None - 1 Human 9.0 pIC50 = 9 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 453 7 2 3 5.5 COc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 10.1021/jm049530m
CHEMBL194601 77210 0 None - 1 Human 9.0 pIC50 = 9 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 453 7 2 3 5.5 COc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 10.1021/jm049530m
44455539 173761 0 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 465 8 2 6 3.9 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL428775 173761 0 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 465 8 2 6 3.9 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
45271892 202119 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 515 5 1 5 4.3 O=C(C=C1CCN(C(=O)c2ccc3c(c2)OCO3)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL551739 202119 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 515 5 1 5 4.3 O=C(C=C1CCN(C(=O)c2ccc3c(c2)OCO3)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
71460523 88269 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 423 7 3 4 3.7 O=C(Nc1ccccc1OCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160099 88269 0 None - 1 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 423 7 3 4 3.7 O=C(Nc1ccccc1OCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
45271891 202118 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 501 6 1 4 4.5 COc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)cc1 10.1016/j.bmc.2009.06.066
CHEMBL551738 202118 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 501 6 1 4 4.5 COc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)cc1 10.1016/j.bmc.2009.06.066
11363005 67280 0 None - 1 Human 8.0 pIC50 = 8 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 453 7 2 3 5.5 COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL175634 67280 0 None - 1 Human 8.0 pIC50 = 8 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 453 7 2 3 5.5 COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11329244 77891 11 None -20 7 Mouse 8.0 pIC50 = 8 Functional
Inhibition of eotaxin-induced chemotaxis of mouse eosinophilsInhibition of eotaxin-induced chemotaxis of mouse eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
CHEMBL195433 77891 11 None -20 7 Mouse 8.0 pIC50 = 8 Functional
Inhibition of eotaxin-induced chemotaxis of mouse eosinophilsInhibition of eotaxin-induced chemotaxis of mouse eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
45269392 202805 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 374 5 1 2 4.4 O=C(/C=C/c1ccccc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL560198 202805 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 374 5 1 2 4.4 O=C(/C=C/c1ccccc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
71449694 88273 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 437 8 3 4 3.9 O=C(Nc1ccccc1COCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160102 88273 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 437 8 3 4 3.9 O=C(Nc1ccccc1COCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
70694703 82922 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 578 5 2 3 6.1 O=C(Nc1cccc(Br)c1)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
CHEMBL2057764 82922 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 578 5 2 3 6.1 O=C(Nc1cccc(Br)c1)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
44451981 168050 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 454 6 1 3 6.2 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1cccc(Oc2ccccc2)c1 10.1016/j.bmc.2007.10.003
CHEMBL412061 168050 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 454 6 1 3 6.2 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1cccc(Oc2ccccc2)c1 10.1016/j.bmc.2007.10.003
44282031 126593 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 488 8 2 5 3.2 CC(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)N1CCCC1 10.1016/s0960-894x(01)00249-9
CHEMBL34839 126593 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 488 8 2 5 3.2 CC(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)N1CCCC1 10.1016/s0960-894x(01)00249-9
11363005 67280 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 453 7 2 3 5.5 COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL175634 67280 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 453 7 2 3 5.5 COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44281673 117133 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 572 10 3 5 5.6 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N[C@H](C(=O)Nc1ccccc1)c1ccccc1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL32410 117133 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 572 10 3 5 5.6 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N[C@H](C(=O)Nc1ccccc1)c1ccccc1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
76331527 110140 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 486 6 1 3 6.6 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1OC1CCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084575 110140 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 486 6 1 3 6.6 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1OC1CCCCC1 10.1016/j.bmc.2008.08.006
71458677 88245 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 423 7 3 4 3.7 O=C(Nc1ccc(OCCO)cc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2159868 88245 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 423 7 3 4 3.7 O=C(Nc1ccc(OCCO)cc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
76316939 110144 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 513 5 1 3 5.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084579 110144 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 513 5 1 3 5.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCCCCC1 10.1016/j.bmc.2008.08.006
45270978 203293 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 489 5 1 3 4.7 O=C(C=C1CCN(C(=O)c2cccc(F)c2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL563536 203293 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 489 5 1 3 4.7 O=C(C=C1CCN(C(=O)c2cccc(F)c2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
44282048 118413 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 520 9 3 5 4.2 COc1ccccc1NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(C#N)cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL32852 118413 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 520 9 3 5 4.2 COc1ccccc1NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(C#N)cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
44282385 106859 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 562 7 1 6 6.1 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1nc(C(=O)N2CCc3ccccc3C2)cs1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL287320 106859 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 562 7 1 6 6.1 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1nc(C(=O)N2CCc3ccccc3C2)cs1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
76327878 110136 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 500 5 1 4 4.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccncc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084571 110136 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 500 5 1 4 4.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccncc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
70686358 82921 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 578 5 2 3 6.1 O=C(Nc1ccccc1Br)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
CHEMBL2057763 82921 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 578 5 2 3 6.1 O=C(Nc1ccccc1Br)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
70682102 82924 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 518 5 2 3 5.4 O=C(Nc1ccccc1F)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
CHEMBL2057766 82924 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 518 5 2 3 5.4 O=C(Nc1ccccc1F)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
2729098 87270 2 None -11 2 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 362 4 1 2 4.4 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1 10.1016/j.bmc.2007.10.003
CHEMBL214726 87270 2 None -11 2 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 362 4 1 2 4.4 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1 10.1016/j.bmc.2007.10.003
76309741 110145 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 500 5 1 4 4.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ncccc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084580 110145 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 500 5 1 4 4.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ncccc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
44399469 172905 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibitory concentration against BaF3 cell line expressed recombinant human CCR3 using the LDH assayInhibitory concentration against BaF3 cell line expressed recombinant human CCR3 using the LDH assay
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL426089 172905 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibitory concentration against BaF3 cell line expressed recombinant human CCR3 using the LDH assayInhibitory concentration against BaF3 cell line expressed recombinant human CCR3 using the LDH assay
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
71449677 88240 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 448 5 2 4 2.3 CS(=O)(=O)N1CCC(NC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 10.1016/j.bmcl.2012.09.035
CHEMBL2159863 88240 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 448 5 2 4 2.3 CS(=O)(=O)N1CCC(NC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 10.1016/j.bmcl.2012.09.035
45271843 203149 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 517 6 2 5 4.2 COc1ccc(O)c(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c1 10.1016/j.bmc.2009.06.066
CHEMBL562574 203149 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 517 6 2 5 4.2 COc1ccc(O)c(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c1 10.1016/j.bmc.2009.06.066
45267629 203129 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 424 5 1 2 5.7 O=C(N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
CHEMBL562475 203129 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 424 5 1 2 5.7 O=C(N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
23509697 201729 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assay
ChEMBL 440 6 2 4 3.6 COc1cccc(NC(=O)N2CCNC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL54273 201729 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
In vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assay
ChEMBL 440 6 2 4 3.6 COc1cccc(NC(=O)N2CCNC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
44282006 130425 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 525 10 3 5 4.3 COc1ccc(C[C@H](NC(=O)c2cccc3ccccc23)C(=O)N[C@@H](C)C(=O)Nc2ccccc2OC)cc1 10.1016/s0960-894x(01)00249-9
CHEMBL36195 130425 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 525 10 3 5 4.3 COc1ccc(C[C@H](NC(=O)c2cccc3ccccc23)C(=O)N[C@@H](C)C(=O)Nc2ccccc2OC)cc1 10.1016/s0960-894x(01)00249-9
44440402 100692 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of calcium fluxAntagonist activity at human CCR3 receptor assessed as inhibition of calcium flux
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL248179 100692 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of calcium fluxAntagonist activity at human CCR3 receptor assessed as inhibition of calcium flux
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
44440402 100692 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of eotaxin-induced eosinophil shape changeAntagonist activity at human CCR3 receptor assessed as inhibition of eotaxin-induced eosinophil shape change
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL248179 100692 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of eotaxin-induced eosinophil shape changeAntagonist activity at human CCR3 receptor assessed as inhibition of eotaxin-induced eosinophil shape change
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
45270977 201930 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 409 4 1 3 3.2 CC(=O)N1CCC(=CC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 10.1016/j.bmc.2009.06.066
CHEMBL550255 201930 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 409 4 1 3 3.2 CC(=O)N1CCC(=CC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 10.1016/j.bmc.2009.06.066
70682100 82915 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 568 4 1 3 5.9 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCN(C(=O)c2c(Cl)cccc2Cl)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057757 82915 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 568 4 1 3 5.9 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCN(C(=O)c2c(Cl)cccc2Cl)CC1 10.1016/j.bmcl.2012.06.042
11430170 130611 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 423 6 2 2 5.5 O=C(Nc1ccccc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL362466 130611 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 423 6 2 2 5.5 O=C(Nc1ccccc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
45271911 201836 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 362 5 1 2 3.9 O=C(Cc1ccccc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL549514 201836 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 362 5 1 2 3.9 O=C(Cc1ccccc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
44452250 103009 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 362 4 1 2 4.8 O=C(Nc1ccccc1)C1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
CHEMBL260900 103009 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 362 4 1 2 4.8 O=C(Nc1ccccc1)C1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
44281793 106890 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 414 7 1 5 4.7 CCn1ccnc1[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL287538 106890 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 414 7 1 5 4.7 CCn1ccnc1[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
70688459 82914 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 568 5 1 3 6.7 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(Cc2c(Cl)cccc2Cl)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057756 82914 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 568 5 1 3 6.7 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(Cc2c(Cl)cccc2Cl)CC1 10.1016/j.bmcl.2012.06.042
44281891 132486 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 474 8 2 6 4.7 CCNC(=O)c1csc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 10.1016/s0960-894x(01)00249-9
CHEMBL36473 132486 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 474 8 2 6 4.7 CCNC(=O)c1csc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 10.1016/s0960-894x(01)00249-9
44281612 116402 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 510 9 3 5 4.2 C[C@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccccc1 10.1016/s0960-894x(01)00249-9
CHEMBL32224 116402 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 510 9 3 5 4.2 C[C@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccccc1 10.1016/s0960-894x(01)00249-9
10194663 88275 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 423 7 3 4 3.7 O=C(Nc1cccc(OCCO)c1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160104 88275 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 423 7 3 4 3.7 O=C(Nc1cccc(OCCO)c1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
70692659 82860 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 499 7 1 3 5.5 O=C(NCCCN1CCC(C(c2ccccc2)c2ccccc2)CC1)N1CCc2cc(F)ccc2C1=O 10.1016/j.bmcl.2012.06.042
CHEMBL2057490 82860 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 499 7 1 3 5.5 O=C(NCCCN1CCC(C(c2ccccc2)c2ccccc2)CC1)N1CCc2cc(F)ccc2C1=O 10.1016/j.bmcl.2012.06.042
11409583 76557 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 507 8 2 4 5.9 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1021/jm049530m
CHEMBL193575 76557 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 507 8 2 4 5.9 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1021/jm049530m
11454941 77917 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 505 7 2 6 4.7 Cc1nnnn1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL195555 77917 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 505 7 2 6 4.7 Cc1nnnn1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
11328714 85773 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113074 85773 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11488078 85776 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113077 85776 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11169258 147675 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 587 8 2 10 3.8 Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1021/jm049530m
CHEMBL382108 147675 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 587 8 2 10 3.8 Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1021/jm049530m
44401328 77871 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL195348 77871 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 10.1021/jm049530m
71460525 88282 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 526 6 3 5 3.4 O=C(NC1CCN(S(=O)(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160111 88282 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 526 6 3 5 3.4 O=C(NC1CCN(S(=O)(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
44290039 185581 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL46905 185581 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
11953409 100991 0 None 7 4 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at CCR3 in human eosinophils assessed as eotaxin-induced calcium mobilization by FLIPR assayAntagonist activity at CCR3 in human eosinophils assessed as eotaxin-induced calcium mobilization by FLIPR assay
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249854 100991 0 None 7 4 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at CCR3 in human eosinophils assessed as eotaxin-induced calcium mobilization by FLIPR assayAntagonist activity at CCR3 in human eosinophils assessed as eotaxin-induced calcium mobilization by FLIPR assay
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44447144 175551 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 483 11 3 7 3.0 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL437396 175551 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 483 11 3 7 3.0 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
10474776 120434 42 None - 1 Human 7.7 pIC50 = 7.7 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand, using [Ca2+] mobilization assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand, using [Ca2+] mobilization assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL33227 120434 42 None - 1 Human 7.7 pIC50 = 7.7 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand, using [Ca2+] mobilization assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand, using [Ca2+] mobilization assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
44281975 106405 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 491 8 2 6 3.9 C[C@@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)OC(C)(C)C 10.1016/s0960-894x(01)00249-9
CHEMBL284166 106405 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 491 8 2 6 3.9 C[C@@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)OC(C)(C)C 10.1016/s0960-894x(01)00249-9
44452168 102626 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 464 5 1 2 6.6 O=C(NC1C[C@@H]2CC[C@@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2007.10.003
CHEMBL258996 102626 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 464 5 1 2 6.6 O=C(NC1C[C@@H]2CC[C@@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2007.10.003
24882359 199826 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 464 5 1 2 6.6 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2008.08.006
CHEMBL522295 199826 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 464 5 1 2 6.6 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2008.08.006
70696744 82861 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 464 5 1 2 6.6 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2012.06.042
CHEMBL2057491 82861 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 464 5 1 2 6.6 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2012.06.042
24882359 199826 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 464 5 1 2 6.6 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
CHEMBL522295 199826 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 464 5 1 2 6.6 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
3492 7479 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
In vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assay
ChEMBL 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 10.1016/s0960-894x(02)00206-8
9868459 7479 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
In vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assay
ChEMBL 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 10.1016/s0960-894x(02)00206-8
CHEMBL50593 7479 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
In vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assay
ChEMBL 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 10.1016/s0960-894x(02)00206-8
11272103 131153 0 None -1995 8 Mouse 7.7 pIC50 = 7.7 Functional
Inhibition of eotaxin-induced chemotaxis of mouse eosinophilsInhibition of eotaxin-induced chemotaxis of mouse eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL363840 131153 0 None -1995 8 Mouse 7.7 pIC50 = 7.7 Functional
Inhibition of eotaxin-induced chemotaxis of mouse eosinophilsInhibition of eotaxin-induced chemotaxis of mouse eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
22393339 193515 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assay
ChEMBL 410 7 2 3 4.7 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(Cl)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL48873 193515 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assay
ChEMBL 410 7 2 3 4.7 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(Cl)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
23509693 198272 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assay
ChEMBL 540 6 1 5 5.2 COc1cccc(NC(=O)N2CCN(C(=O)OC(C)(C)C)C(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL51937 198272 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assay
ChEMBL 540 6 1 5 5.2 COc1cccc(NC(=O)N2CCN(C(=O)OC(C)(C)C)C(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
71462227 88279 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 466 4 0 3 6.6 O=C1OC2(CCN(Cc3ccc4cc(F)ccc4c3)CC2)c2ccccc2N1Cc1ccccc1 10.1016/j.bmcl.2012.09.035
CHEMBL2160108 88279 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 466 4 0 3 6.6 O=C1OC2(CCN(Cc3ccc4cc(F)ccc4c3)CC2)c2ccccc2N1Cc1ccccc1 10.1016/j.bmcl.2012.09.035
45270135 202046 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 441 5 2 4 3.6 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)NS(=O)(=O)c1ccccc1 10.1016/j.bmc.2009.06.066
CHEMBL551205 202046 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 441 5 2 4 3.6 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)NS(=O)(=O)c1ccccc1 10.1016/j.bmc.2009.06.066
45268444 202797 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 458 6 1 3 5.6 O=C(C=C1CCC(Oc2ccccc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL560135 202797 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 458 6 1 3 5.6 O=C(C=C1CCC(Oc2ccccc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
44282030 118409 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 461 8 1 7 3.5 CCOC(=O)C1COC([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)=N1 10.1016/s0960-894x(01)00249-9
CHEMBL32850 118409 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 461 8 1 7 3.5 CCOC(=O)C1COC([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)=N1 10.1016/s0960-894x(01)00249-9
76320670 110139 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 454 5 1 4 5.1 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-n1ccnc1 10.1016/j.bmc.2008.08.006
CHEMBL3084574 110139 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 454 5 1 4 5.1 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-n1ccnc1 10.1016/j.bmc.2008.08.006
45270980 201955 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 489 5 1 3 4.7 O=C(C=C1CCN(C(=O)c2ccc(F)cc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL550464 201955 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 489 5 1 3 4.7 O=C(C=C1CCN(C(=O)c2ccc(F)cc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
44447361 101728 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 453 9 4 8 1.8 C[C@@H]([C@@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254503 101728 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophilAntagonist activity at human CCR3 receptor assessed as inhibition of chemotaxis in eosinophil
ChEMBL 453 9 4 8 1.8 C[C@@H]([C@@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
23509695 196518 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assay
ChEMBL 441 6 1 4 4.0 COc1cccc(NC(=O)N2CCOC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL51584 196518 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
In vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assay
ChEMBL 441 6 1 4 4.0 COc1cccc(NC(=O)N2CCOC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
76331526 110131 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 453 5 1 3 5.7 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-n1cccc1 10.1016/j.bmc.2008.08.006
CHEMBL3084566 110131 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 453 5 1 3 5.7 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-n1cccc1 10.1016/j.bmc.2008.08.006
76327880 110143 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 485 5 1 3 5.1 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084578 110143 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 485 5 1 3 5.1 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCCC1 10.1016/j.bmc.2008.08.006
44281943 107009 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 387 6 1 5 4.5 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1cnco1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL288554 107009 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 387 6 1 5 4.5 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1cnco1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
71453334 88267 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 407 6 2 3 4.5 COCc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160097 88267 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 407 6 2 3 4.5 COCc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
76316938 110132 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 499 5 1 3 5.5 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084567 110132 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 499 5 1 3 5.5 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
44512619 110146 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 516 5 1 4 4.2 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1cc[n+]([O-])cc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084581 110146 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 516 5 1 4 4.2 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1cc[n+]([O-])cc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
45270199 203197 0 None 47 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 516 5 1 4 4.2 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1cc[n+]([O-])cc1C(=O)N1CCCCC1 10.1016/j.bmc.2009.06.066
CHEMBL562897 203197 0 None 47 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 516 5 1 4 4.2 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1cc[n+]([O-])cc1C(=O)N1CCCCC1 10.1016/j.bmc.2009.06.066
44401561 130899 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL363373 130899 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 10.1021/jm049530m
45271882 202038 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 366 4 1 2 4.1 O=C(N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccc(F)cc1 10.1016/j.bmc.2009.06.066
CHEMBL551134 202038 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 366 4 1 2 4.1 O=C(N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccc(F)cc1 10.1016/j.bmc.2009.06.066
71455029 88246 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 464 7 2 4 3.8 CN(C)C(=O)COc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2159869 88246 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 464 7 2 4 3.8 CN(C)C(=O)COc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
70696753 82920 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 500 5 2 3 5.3 O=C(Nc1ccccc1)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
CHEMBL2057762 82920 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 500 5 2 3 5.3 O=C(Nc1ccccc1)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
44452009 102722 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 392 5 1 3 4.4 COc1ccc(C(=O)NC2CCN(Cc3ccc4cc(F)ccc4c3)CC2)cc1 10.1016/j.bmc.2007.10.003
CHEMBL259409 102722 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 392 5 1 3 4.4 COc1ccc(C(=O)NC2CCN(Cc3ccc4cc(F)ccc4c3)CC2)cc1 10.1016/j.bmc.2007.10.003
10474776 120434 42 None - 1 Human 7.6 pIC50 = 7.6 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL33227 120434 42 None - 1 Human 7.6 pIC50 = 7.6 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
71453337 88281 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 540 5 2 5 3.8 O=C(NC1CCN(S(=O)(=O)c2ccccc2O)CC1)N1CCCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmcl.2012.09.035
CHEMBL2160110 88281 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 540 5 2 5 3.8 O=C(NC1CCN(S(=O)(=O)c2ccccc2O)CC1)N1CCCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmcl.2012.09.035
44290039 185581 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL46905 185581 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
44282005 130531 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 520 9 3 5 4.2 COc1ccc(C[C@H](NC(=O)c2cccc3ccccc23)C(=O)N[C@@H](C)C(=O)Nc2ccc(C#N)cc2)cc1 10.1016/s0960-894x(01)00249-9
CHEMBL36223 130531 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 520 9 3 5 4.2 COc1ccc(C[C@H](NC(=O)c2cccc3ccccc23)C(=O)N[C@@H](C)C(=O)Nc2ccc(C#N)cc2)cc1 10.1016/s0960-894x(01)00249-9
45269291 203219 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 427 5 2 4 3.2 O=C(N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)NS(=O)(=O)c1ccccc1 10.1016/j.bmc.2009.06.066
CHEMBL563019 203219 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 427 5 2 4 3.2 O=C(N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)NS(=O)(=O)c1ccccc1 10.1016/j.bmc.2009.06.066
45269385 203259 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 424 5 1 2 5.7 O=C(N[C@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
CHEMBL563319 203259 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 424 5 1 2 5.7 O=C(N[C@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
44281668 117199 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 500 8 3 4 4.4 C[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1cccnc1 10.1016/s0960-894x(01)00249-9
CHEMBL32451 117199 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 500 8 3 4 4.4 C[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1cccnc1 10.1016/s0960-894x(01)00249-9
44452168 102626 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 464 5 1 2 6.6 O=C(NC1C[C@@H]2CC[C@@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2007.10.003
CHEMBL258996 102626 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 464 5 1 2 6.6 O=C(NC1C[C@@H]2CC[C@@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2007.10.003
76320671 110141 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 471 5 1 3 5.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1N1CCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084576 110141 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 471 5 1 3 5.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1N1CCCCC1 10.1016/j.bmc.2008.08.006
71456839 88271 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 467 10 3 5 3.8 O=C(Nc1ccccc1OCCOCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160100 88271 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 467 10 3 5 3.8 O=C(Nc1ccccc1OCCOCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
44452220 168055 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 452 5 1 2 6.4 CC1(NC(=O)c2ccccc2-c2ccccc2)CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
CHEMBL412072 168055 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 452 5 1 2 6.4 CC1(NC(=O)c2ccccc2-c2ccccc2)CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
76313428 110129 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 465 5 1 3 6.0 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1cccnc1 10.1016/j.bmc.2008.08.006
CHEMBL3084564 110129 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 465 5 1 3 6.0 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1cccnc1 10.1016/j.bmc.2008.08.006
70688469 82962 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 534 5 2 3 5.9 O=C(Nc1ccccc1Cl)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
CHEMBL2058070 82962 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 534 5 2 3 5.9 O=C(Nc1ccccc1Cl)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
44452119 103129 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 380 4 1 2 4.5 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1F 10.1016/j.bmc.2007.10.003
CHEMBL261574 103129 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 380 4 1 2 4.5 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1F 10.1016/j.bmc.2007.10.003
44281859 116602 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 463 9 2 6 3.2 CCOC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL32334 116602 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 463 9 2 6 3.2 CCOC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
44289926 184338 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 453 9 2 4 4.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL46404 184338 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 453 9 2 4 4.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
44289927 175106 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL43423 175106 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
45268462 202994 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 517 6 2 5 4.2 COc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c(O)c1 10.1016/j.bmc.2009.06.066
CHEMBL561535 202994 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 517 6 2 5 4.2 COc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c(O)c1 10.1016/j.bmc.2009.06.066
45269302 202895 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 531 7 1 5 4.5 COc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)cc1OC 10.1016/j.bmc.2009.06.066
CHEMBL560995 202895 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 531 7 1 5 4.5 COc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)cc1OC 10.1016/j.bmc.2009.06.066
70688470 82965 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 542 6 2 3 6.4 CC(C)c1ccccc1NC(=O)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
CHEMBL2058073 82965 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 542 6 2 3 6.4 CC(C)c1ccccc1NC(=O)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
9892753 23272 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 516 8 3 4 5.5 CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm049530m
CHEMBL123611 23272 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 516 8 3 4 5.5 CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm049530m
44281667 122439 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 524 10 3 5 3.9 CC(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)NCc1ccccc1 10.1016/s0960-894x(01)00249-9
CHEMBL33537 122439 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 524 10 3 5 3.9 CC(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)NCc1ccccc1 10.1016/s0960-894x(01)00249-9
45273705 202577 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 376 5 1 2 4.3 O=C(Cc1ccccc1)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2009.06.066
CHEMBL557936 202577 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 376 5 1 2 4.3 O=C(Cc1ccccc1)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2009.06.066
10050884 161431 14 None -204 3 Mouse 7.5 pIC50 = 7.5 Functional
Antagonist activity at CCR3 receptor in mouse eosinophil assessed as as inhibition of chemotaxisAntagonist activity at CCR3 receptor in mouse eosinophil assessed as as inhibition of chemotaxis
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
CHEMBL399495 161431 14 None -204 3 Mouse 7.5 pIC50 = 7.5 Functional
Antagonist activity at CCR3 receptor in mouse eosinophil assessed as as inhibition of chemotaxisAntagonist activity at CCR3 receptor in mouse eosinophil assessed as as inhibition of chemotaxis
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
70684230 82964 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 530 6 2 4 5.3 COc1ccccc1NC(=O)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
CHEMBL2058072 82964 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 530 6 2 4 5.3 COc1ccccc1NC(=O)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
70682099 82910 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 532 4 1 3 5.2 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057752 82910 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 532 4 1 3 5.2 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2ccc(F)cc2)CC1 10.1016/j.bmcl.2012.06.042
10474776 120434 42 None - 1 Human 7.5 pIC50 = 7.5 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL33227 120434 42 None - 1 Human 7.5 pIC50 = 7.5 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
45268519 203052 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 409 5 0 2 6.4 O=C(c1ccccc1-c1ccccc1)C1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL561941 203052 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 409 5 0 2 6.4 O=C(c1ccccc1-c1ccccc1)C1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
44281966 106588 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 403 6 1 5 4.9 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1nccs1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL285444 106588 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 403 6 1 5 4.9 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)c1nccs1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
44452361 103283 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 338 5 1 2 3.7 O=C(NC1CCN(C/C=C/c2ccc(F)cc2)CC1)c1ccccc1 10.1016/j.bmc.2007.10.003
CHEMBL262588 103283 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 338 5 1 2 3.7 O=C(NC1CCN(C/C=C/c2ccc(F)cc2)CC1)c1ccccc1 10.1016/j.bmc.2007.10.003
10474776 120434 42 None - 1 Human 7.5 pIC50 = 7.5 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand, using [Ca2+] mobilization assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand, using [Ca2+] mobilization assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL33227 120434 42 None - 1 Human 7.5 pIC50 = 7.5 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand, using [Ca2+] mobilization assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand, using [Ca2+] mobilization assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
11442439 130835 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 455 6 2 2 5.9 Cc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1F 10.1021/jm049530m
CHEMBL363166 130835 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 455 6 2 2 5.9 Cc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1F 10.1021/jm049530m
44386406 69261 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 461 9 2 6 3.3 C=C(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)OCC 10.1016/s0960-894x(01)00249-9
CHEMBL178019 69261 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 461 9 2 6 3.3 C=C(NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)OCC 10.1016/s0960-894x(01)00249-9
6918497 120207 2 None -213 4 Mouse 6.5 pIC50 = 6.5 Functional
Inhibitory activity against I-Eotaxin induced [Ca2+] response in mouse CCR3 receptorInhibitory activity against I-Eotaxin induced [Ca2+] response in mouse CCR3 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL277930 120207 2 None -213 4 Mouse 6.5 pIC50 = 6.5 Functional
Inhibitory activity against I-Eotaxin induced [Ca2+] response in mouse CCR3 receptorInhibitory activity against I-Eotaxin induced [Ca2+] response in mouse CCR3 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL331897 120207 2 None -213 4 Mouse 6.5 pIC50 = 6.5 Functional
Inhibitory activity against I-Eotaxin induced [Ca2+] response in mouse CCR3 receptorInhibitory activity against I-Eotaxin induced [Ca2+] response in mouse CCR3 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
44452044 162866 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 392 5 1 3 4.4 COc1cccc(C(=O)NC2CCN(Cc3ccc4cc(F)ccc4c3)CC2)c1 10.1016/j.bmc.2007.10.003
CHEMBL406296 162866 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 392 5 1 3 4.4 COc1cccc(C(=O)NC2CCN(Cc3ccc4cc(F)ccc4c3)CC2)c1 10.1016/j.bmc.2007.10.003
70690518 82906 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 555 4 1 4 5.0 CN1CN(c2ccccc2)C2(CCN(C(=O)NC3C[C@H]4CC[C@H](C3)N4Cc3ccc4cc(F)ccc4c3)CC2)C1=O 10.1016/j.bmcl.2012.06.042
CHEMBL2057748 82906 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 555 4 1 4 5.0 CN1CN(c2ccccc2)C2(CCN(C(=O)NC3C[C@H]4CC[C@H](C3)N4Cc3ccc4cc(F)ccc4c3)CC2)C1=O 10.1016/j.bmcl.2012.06.042
10474776 120434 42 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using [Ca2+] mobilization assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using [Ca2+] mobilization assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL33227 120434 42 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using [Ca2+] mobilization assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using [Ca2+] mobilization assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
44451928 165942 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 438 5 1 2 6.0 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2007.10.003
CHEMBL409830 165942 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 438 5 1 2 6.0 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2007.10.003
44451928 165942 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 438 5 1 2 6.0 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
CHEMBL409830 165942 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 438 5 1 2 6.0 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
45268458 203522 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 517 6 2 5 4.2 COc1cccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c1O 10.1016/j.bmc.2009.06.066
CHEMBL565165 203522 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 517 6 2 5 4.2 COc1cccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c1O 10.1016/j.bmc.2009.06.066
71460524 88280 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 474 5 1 3 4.9 O=C(NC1CCN(Cc2ccccc2)CC1)N1CCCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmcl.2012.09.035
CHEMBL2160109 88280 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 474 5 1 3 4.9 O=C(NC1CCN(Cc2ccccc2)CC1)N1CCCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmcl.2012.09.035
70686357 82911 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 529 4 2 4 4.6 Nc1ccc(C(=O)N2CCCN(C(=O)NC3C[C@H]4CC[C@H](C3)N4Cc3ccc4cc(F)ccc4c3)CC2)cc1 10.1016/j.bmcl.2012.06.042
CHEMBL2057753 82911 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 529 4 2 4 4.6 Nc1ccc(C(=O)N2CCCN(C(=O)NC3C[C@H]4CC[C@H](C3)N4Cc3ccc4cc(F)ccc4c3)CC2)cc1 10.1016/j.bmcl.2012.06.042
44282280 127171 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 463 9 2 6 3.2 CCOC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL35341 127171 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 463 9 2 6 3.2 CCOC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
11329244 77891 11 None 20 7 Human 8.4 pIC50 = 8.4 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
CHEMBL195433 77891 11 None 20 7 Human 8.4 pIC50 = 8.4 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
11340670 134012 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 483 7 2 3 5.8 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F 10.1021/jm049530m
CHEMBL365820 134012 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 483 7 2 3 5.8 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F 10.1021/jm049530m
11397114 140247 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2cn[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL3706810 140247 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2cn[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44401123 143058 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 516 7 2 5 4.9 N#CC1=CC(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)CC=C1n1cccn1 10.1021/jm049530m
CHEMBL373347 143058 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 516 7 2 5 4.9 N#CC1=CC(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)CC=C1n1cccn1 10.1021/jm049530m
9847583 203245 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 471 5 1 3 4.5 O=C(C=C1CCN(C(=O)c2ccccc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL563189 203245 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 471 5 1 3 4.5 O=C(C=C1CCN(C(=O)c2ccccc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
45273624 202446 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 489 5 1 3 4.7 O=C(C=C1CCN(C(=O)c2ccccc2F)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL556500 202446 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 489 5 1 3 4.7 O=C(C=C1CCN(C(=O)c2ccccc2F)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
70696765 82963 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 545 6 2 5 5.2 O=C(Nc1ccccc1[N+](=O)[O-])[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
CHEMBL2058071 82963 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 545 6 2 5 5.2 O=C(Nc1ccccc1[N+](=O)[O-])[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
25024651 122814 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Inhibition of CCR3 in human eosinophil assessed as inhibition of eotaxin-induced Ca2+ influxInhibition of CCR3 in human eosinophil assessed as inhibition of eotaxin-induced Ca2+ influx
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
CHEMBL3355956 122814 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Inhibition of CCR3 in human eosinophil assessed as inhibition of eotaxin-induced Ca2+ influxInhibition of CCR3 in human eosinophil assessed as inhibition of eotaxin-induced Ca2+ influx
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
44281706 118335 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 496 9 3 5 3.8 O=C(CNC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)Nc1ccccc1 10.1016/s0960-894x(01)00249-9
CHEMBL32806 118335 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 496 9 3 5 3.8 O=C(CNC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)Nc1ccccc1 10.1016/s0960-894x(01)00249-9
11227406 101120 2 None -107 4 Mouse 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in BALB/c mouse eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in BALB/c mouse eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
CHEMBL250689 101120 2 None -107 4 Mouse 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in BALB/c mouse eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in BALB/c mouse eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
71460504 88241 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 369 4 2 2 4.2 O=C(NC1CCCCC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2159864 88241 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 369 4 2 2 4.2 O=C(NC1CCCCC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
11227406 101120 2 None -107 4 Mouse 7.4 pIC50 = 7.4 Functional
Inhibition of eotaxin-induced chemotaxis of mouse eosinophilsInhibition of eotaxin-induced chemotaxis of mouse eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL250689 101120 2 None -107 4 Mouse 7.4 pIC50 = 7.4 Functional
Inhibition of eotaxin-induced chemotaxis of mouse eosinophilsInhibition of eotaxin-induced chemotaxis of mouse eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
71456816 88243 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 407 6 3 3 3.9 O=C(Nc1ccccc1CCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2159866 88243 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 407 6 3 3 3.9 O=C(Nc1ccccc1CCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
71455044 88276 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 450 8 2 4 4.3 CN(C)CCOc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160105 88276 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 450 8 2 4 4.3 CN(C)CCOc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
71453336 88277 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 436 7 3 4 3.2 NC(=O)COc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160106 88277 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 436 7 3 4 3.2 NC(=O)COc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
76327879 110142 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 527 6 1 3 6.3 CN(C(=O)c1ccccc1C(=O)N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)C1CCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084577 110142 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 527 6 1 3 6.3 CN(C(=O)c1ccccc1C(=O)N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)C1CCCCC1 10.1016/j.bmc.2008.08.006
70682098 82908 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 545 4 2 4 5.3 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCC(n2c(=O)[nH]c3c(F)cccc32)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057750 82908 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 545 4 2 4 5.3 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCC(n2c(=O)[nH]c3c(F)cccc32)CC1 10.1016/j.bmcl.2012.06.042
70682101 82916 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 530 4 2 4 4.7 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2ccc(O)cc2)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057758 82916 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 530 4 2 4 4.7 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2ccc(O)cc2)CC1 10.1016/j.bmcl.2012.06.042
44281852 106458 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 511 8 3 3 5.1 Cc1ccc(C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](C)C(=O)Nc2ccc(Cl)cc2)c(C)c1 10.1016/s0960-894x(01)00249-9
CHEMBL284531 106458 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 511 8 3 3 5.1 Cc1ccc(C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](C)C(=O)Nc2ccc(Cl)cc2)c(C)c1 10.1016/s0960-894x(01)00249-9
44281944 128571 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 529 9 3 4 5.0 COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)c2cccc3ccccc23)cc1 10.1016/s0960-894x(01)00249-9
CHEMBL35896 128571 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 529 9 3 4 5.0 COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)c2cccc3ccccc23)cc1 10.1016/s0960-894x(01)00249-9
70692666 82918 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 554 5 1 3 5.5 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)C2(c3ccccc3)CC2)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057760 82918 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 554 5 1 3 5.5 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)C2(c3ccccc3)CC2)CC1 10.1016/j.bmcl.2012.06.042
45273639 203204 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 517 6 2 5 4.2 COc1cccc(O)c1C(=O)N1CCC(=CC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 10.1016/j.bmc.2009.06.066
CHEMBL562922 203204 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 517 6 2 5 4.2 COc1cccc(O)c1C(=O)N1CCC(=CC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 10.1016/j.bmc.2009.06.066
44452172 102627 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 378 4 1 3 5.2 O=C(Nc1ccccc1)OC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
CHEMBL258997 102627 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 378 4 1 3 5.2 O=C(Nc1ccccc1)OC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
76324312 110133 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 514 5 1 4 4.3 CN1CCN(C(=O)c2ccccc2C(=O)N[C@H]2C[C@@H]3CC[C@H](C2)N3Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2008.08.006
CHEMBL3084568 110133 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 514 5 1 4 4.3 CN1CCN(C(=O)c2ccccc2C(=O)N[C@H]2C[C@@H]3CC[C@H](C2)N3Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2008.08.006
10474776 120434 42 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL33227 120434 42 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
9957612 170041 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 499 8 3 3 5.0 C[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccccc1 10.1016/s0960-894x(01)00249-9
CHEMBL418588 170041 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 499 8 3 3 5.0 C[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccccc1 10.1016/s0960-894x(01)00249-9
45273632 202482 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2cccc(O)c2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL556916 202482 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2cccc(O)c2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
44455847 162225 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 501 9 2 6 4.7 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL403839 162225 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 501 9 2 6 4.7 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
45272697 202400 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 501 6 1 4 4.5 COc1ccccc1C(=O)N1CCC(=CC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 10.1016/j.bmc.2009.06.066
CHEMBL556227 202400 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 501 6 1 4 4.5 COc1ccccc1C(=O)N1CCC(=CC(=O)N[C@@H]2CCN(Cc3ccc4cc(F)ccc4c3)C2)CC1 10.1016/j.bmc.2009.06.066
45273698 203205 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2ccc(O)cc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL562923 203205 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2ccc(O)cc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
45273689 202505 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 501 6 1 4 4.5 COc1cccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c1 10.1016/j.bmc.2009.06.066
CHEMBL557118 202505 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 501 6 1 4 4.5 COc1cccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)c1 10.1016/j.bmc.2009.06.066
71455028 88242 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 363 4 2 2 4.4 O=C(Nc1ccccc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2159865 88242 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 363 4 2 2 4.4 O=C(Nc1ccccc1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
71453335 88274 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 437 8 3 4 4.1 O=C(Nc1ccccc1OCCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160103 88274 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 437 8 3 4 4.1 O=C(Nc1ccccc1OCCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
11179592 76367 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 501 6 2 2 6.2 O=C(Nc1ccc(Br)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL193442 76367 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 501 6 2 2 6.2 O=C(Nc1ccc(Br)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11316656 77037 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 441 6 2 2 5.6 O=C(Nc1ccc(F)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL194141 77037 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 441 6 2 2 5.6 O=C(Nc1ccc(F)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44281755 106463 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 502 9 3 6 3.8 COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2cscn2)NC(=O)c2cccc3ccccc23)cc1 10.1016/s0960-894x(01)00249-9
CHEMBL284576 106463 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 502 9 3 6 3.8 COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2cscn2)NC(=O)c2cccc3ccccc23)cc1 10.1016/s0960-894x(01)00249-9
44281999 128635 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 459 8 1 7 4.6 CCOC(=O)c1coc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 10.1016/s0960-894x(01)00249-9
CHEMBL35900 128635 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 459 8 1 7 4.6 CCOC(=O)c1coc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 10.1016/s0960-894x(01)00249-9
71462226 88268 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 421 7 3 3 4.3 O=C(Nc1ccccc1CCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160098 88268 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 421 7 3 3 4.3 O=C(Nc1ccccc1CCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
70694702 82913 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 548 4 2 4 4.9 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2c(O)cccc2F)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057755 82913 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 548 4 2 4 4.9 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2c(O)cccc2F)CC1 10.1016/j.bmcl.2012.06.042
70690519 82907 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 527 4 2 4 5.2 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057749 82907 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 527 4 2 4 5.2 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 10.1016/j.bmcl.2012.06.042
10474776 120434 42 None - 1 Human 7.3 pIC50 = 7.3 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL33227 120434 42 None - 1 Human 7.3 pIC50 = 7.3 Functional
Agonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assayAgonistic activity against C-C chemokine receptor type 3 by displacing Eotaxin radioligand, using Eosinophil chemotaxis assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
45271905 201800 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 438 5 1 2 6.0 O=C(NC1CCCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
CHEMBL549302 201800 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 438 5 1 2 6.0 O=C(NC1CCCN(Cc2ccc3cc(F)ccc3c2)C1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2009.06.066
70690520 82919 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 550 5 1 4 4.6 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(S(=O)(=O)c2ccccc2)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057761 82919 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 550 5 1 4 4.6 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(S(=O)(=O)c2ccccc2)CC1 10.1016/j.bmcl.2012.06.042
9952288 117281 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 389 6 1 5 3.5 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C1=NCCO1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL32493 117281 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 389 6 1 5 3.5 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C1=NCCO1)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
76324313 110138 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 465 5 1 3 6.0 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccn1 10.1016/j.bmc.2008.08.006
CHEMBL3084573 110138 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 465 5 1 3 6.0 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccn1 10.1016/j.bmc.2008.08.006
70690517 82905 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 541 4 2 4 4.6 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.bmcl.2012.06.042
CHEMBL2057747 82905 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 541 4 2 4 4.6 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCC2(CC1)C(=O)NCN2c1ccccc1 10.1016/j.bmcl.2012.06.042
45268467 203021 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 505 5 2 4 4.4 O=C(C=C1CCN(C(=O)c2ccc(F)cc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL561740 203021 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 505 5 2 4 4.4 O=C(C=C1CCN(C(=O)c2ccc(F)cc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
6918497 120207 2 None 1 4 Human 8.2 pIC50 = 8.2 Functional
Inhibitory activity against I-Eotaxin induced [Ca2+] response in human CCR3 receptorInhibitory activity against I-Eotaxin induced [Ca2+] response in human CCR3 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL277930 120207 2 None 1 4 Human 8.2 pIC50 = 8.2 Functional
Inhibitory activity against I-Eotaxin induced [Ca2+] response in human CCR3 receptorInhibitory activity against I-Eotaxin induced [Ca2+] response in human CCR3 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL331897 120207 2 None 1 4 Human 8.2 pIC50 = 8.2 Functional
Inhibitory activity against I-Eotaxin induced [Ca2+] response in human CCR3 receptorInhibitory activity against I-Eotaxin induced [Ca2+] response in human CCR3 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
44455872 162294 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 467 9 2 4 5.1 CC(=O)c1cc(NC(=O)N[C@@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL404202 162294 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxisAntagonist activity at human CCR3 receptor in human eosinophil assessed as inhibition of eotaxin-induced chemotaxis
ChEMBL 467 9 2 4 5.1 CC(=O)c1cc(NC(=O)N[C@@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
44281987 106424 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 542 9 3 4 5.4 C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccc(-c2ccccc2)cc1 10.1016/s0960-894x(01)00249-9
CHEMBL284313 106424 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 542 9 3 4 5.4 C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccc(-c2ccccc2)cc1 10.1016/s0960-894x(01)00249-9
44281794 174790 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 524 9 2 5 4.3 C[C@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)N(C)c1ccccc1 10.1016/s0960-894x(01)00249-9
CHEMBL432088 174790 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 524 9 2 5 4.3 C[C@H](NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12)C(=O)N(C)c1ccccc1 10.1016/s0960-894x(01)00249-9
44452304 164624 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 348 5 1 2 4.7 Fc1ccc2cc(CN3CCC(NCc4ccccc4)CC3)ccc2c1 10.1016/j.bmc.2007.10.003
CHEMBL408368 164624 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 348 5 1 2 4.7 Fc1ccc2cc(CN3CCC(NCc4ccccc4)CC3)ccc2c1 10.1016/j.bmc.2007.10.003
71449695 88278 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 416 5 0 2 5.0 O=C1N(CCc2ccccc2)CCC12CCN(Cc1ccc3cc(F)ccc3c1)CC2 10.1016/j.bmcl.2012.09.035
CHEMBL2160107 88278 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 416 5 0 2 5.0 O=C1N(CCc2ccccc2)CCC12CCN(Cc1ccc3cc(F)ccc3c1)CC2 10.1016/j.bmcl.2012.09.035
9826988 82859 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 492 7 0 7 4.2 Cc1nnc2n(CCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)c(=O)c3ccccc3n12 10.1016/j.bmcl.2012.06.042
CHEMBL2057489 82859 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 492 7 0 7 4.2 Cc1nnc2n(CCCN3CCN(C(c4ccccc4)c4ccccc4)CC3)c(=O)c3ccccc3n12 10.1016/j.bmcl.2012.06.042
76320667 110128 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 465 5 1 3 6.0 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccncc1 10.1016/j.bmc.2008.08.006
CHEMBL3084563 110128 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 465 5 1 3 6.0 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccncc1 10.1016/j.bmc.2008.08.006
24882359 199826 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 464 5 1 2 6.6 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2008.08.006
CHEMBL522295 199826 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 464 5 1 2 6.6 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1ccccc1 10.1016/j.bmc.2008.08.006
70694701 82912 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 582 4 1 3 6.3 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2c(Cl)cccc2Cl)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057754 82912 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 582 4 1 3 6.3 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2c(Cl)cccc2Cl)CC1 10.1016/j.bmcl.2012.06.042
70696752 82917 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 530 4 2 4 4.7 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2ccccc2O)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057759 82917 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 530 4 2 4 4.7 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCCN(C(=O)c2ccccc2O)CC1 10.1016/j.bmcl.2012.06.042
44452086 164666 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 380 4 1 2 4.5 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2007.10.003
CHEMBL408407 164666 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 380 4 1 2 4.5 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2007.10.003
44452086 164666 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 380 4 1 2 4.5 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2009.06.066
CHEMBL408407 164666 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 380 4 1 2 4.5 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccc(F)cc1 10.1016/j.bmc.2009.06.066
44281775 122341 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 524 9 2 5 4.6 C[C@@H](C(=O)Nc1ccccc1)N(C)C(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL33534 122341 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 524 9 2 5 4.6 C[C@@H](C(=O)Nc1ccccc1)N(C)C(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
44281951 127005 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 475 8 1 7 5.1 CCOC(=O)c1csc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 10.1016/s0960-894x(01)00249-9
CHEMBL35217 127005 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 475 8 1 7 5.1 CCOC(=O)c1csc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 10.1016/s0960-894x(01)00249-9
44281686 118803 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 462 9 3 5 2.7 CCNC(=O)C(C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
CHEMBL32895 118803 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 462 9 3 5 2.7 CCNC(=O)C(C)NC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00249-9
44452120 163008 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 380 4 1 2 4.5 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1cccc(F)c1 10.1016/j.bmc.2007.10.003
CHEMBL406468 163008 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 380 4 1 2 4.5 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1cccc(F)c1 10.1016/j.bmc.2007.10.003
76313429 110134 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 501 5 1 4 4.4 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCOCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084569 110134 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 501 5 1 4 4.4 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1C(=O)N1CCOCC1 10.1016/j.bmc.2008.08.006
11953409 100991 0 None -7 4 Mouse 8.2 pIC50 = 8.2 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in BALB/c mouse eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in BALB/c mouse eosinophils
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249854 100991 0 None -7 4 Mouse 8.2 pIC50 = 8.2 Functional
Antagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in BALB/c mouse eosinophilsAntagonist activity at CCR3 assessed as eotaxin-induced chemotaxis in BALB/c mouse eosinophils
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
45269320 203371 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 521 5 2 4 4.9 O=C(C=C1CCN(C(=O)c2ccc(Cl)cc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL564022 203371 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 521 5 2 4 4.9 O=C(C=C1CCN(C(=O)c2ccc(Cl)cc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
44281774 123445 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 501 9 3 4 5.1 COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](CC2CCCCC2)NC(=O)c2cccc3ccccc23)cc1 10.1016/s0960-894x(01)00249-9
CHEMBL33708 123445 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 501 9 3 4 5.1 COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](CC2CCCCC2)NC(=O)c2cccc3ccccc23)cc1 10.1016/s0960-894x(01)00249-9
71456840 88272 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 437 8 2 4 4.4 COCCOc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2160101 88272 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 437 8 2 4 4.4 COCCOc1ccccc1NC(=O)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
44387842 138079 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 369 5 2 3 4.2 CC(=O)c1cccc(NC(=O)NN2CCCCC2Cc2ccc(F)cc2)c1 10.1021/jm049530m
CHEMBL368683 138079 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibition of eotaxin-induced chemotaxis of human eosinophilsInhibition of eotaxin-induced chemotaxis of human eosinophils
ChEMBL 369 5 2 3 4.2 CC(=O)c1cccc(NC(=O)NN2CCCCC2Cc2ccc(F)cc2)c1 10.1021/jm049530m
44452083 102952 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 392 5 1 3 4.4 COc1ccccc1C(=O)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
CHEMBL260649 102952 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 392 5 1 3 4.4 COc1ccccc1C(=O)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
44281872 116135 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 522 8 2 6 6.2 O=C(Nc1ccccc1)c1csc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 10.1016/s0960-894x(01)00249-9
CHEMBL32191 116135 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 522 8 2 6 6.2 O=C(Nc1ccccc1)c1csc([C@H](Cc2ccc([N+](=O)[O-])cc2)NC(=O)c2cccc3ccccc23)n1 10.1016/s0960-894x(01)00249-9
70684221 82904 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 461 3 1 2 5.4 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCc2cc(F)ccc2C1 10.1016/j.bmcl.2012.06.042
CHEMBL2057746 82904 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 461 3 1 2 5.4 O=C(NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)N1CCc2cc(F)ccc2C1 10.1016/j.bmcl.2012.06.042
11227406 101120 2 None 107 4 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at CCR3 in human eosinophils assessed as eotaxin-induced calcium mobilization by FLIPR assayAntagonist activity at CCR3 in human eosinophils assessed as eotaxin-induced calcium mobilization by FLIPR assay
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
CHEMBL250689 101120 2 None 107 4 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at CCR3 in human eosinophils assessed as eotaxin-induced calcium mobilization by FLIPR assayAntagonist activity at CCR3 in human eosinophils assessed as eotaxin-induced calcium mobilization by FLIPR assay
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
70696751 82909 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 542 4 3 5 4.7 Nc1ccc2c(c1)[nH]c(=O)n2C1CCN(C(=O)NC2C[C@H]3CC[C@H](C2)N3Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmcl.2012.06.042
CHEMBL2057751 82909 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 542 4 3 5 4.7 Nc1ccc2c(c1)[nH]c(=O)n2C1CCN(C(=O)NC2C[C@H]3CC[C@H](C2)N3Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmcl.2012.06.042
11227406 101120 2 None 107 4 Human 8.1 pIC50 = 8.1 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL250689 101120 2 None 107 4 Human 8.1 pIC50 = 8.1 Functional
Inhibition of calcium mobilization in human eosinophilsInhibition of calcium mobilization in human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
44512617 202117 0 None 79 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL551735 202117 0 None 79 2 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
22393430 175481 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assay
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL43677 175481 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 activity of compound by using eotaxin induced human eosinophil chemotaxis assay
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
44281754 119955 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 506 8 3 5 4.4 C[C@H](NC(=O)[C@H](Cc1cscn1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccc(Cl)cc1 10.1016/s0960-894x(01)00249-9
CHEMBL33144 119955 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 506 8 3 5 4.4 C[C@H](NC(=O)[C@H](Cc1cscn1)NC(=O)c1cccc2ccccc12)C(=O)Nc1ccc(Cl)cc1 10.1016/s0960-894x(01)00249-9
44452248 103007 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 376 4 0 2 4.7 CN(C(=O)c1ccccc1)C1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
CHEMBL260899 103007 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 376 4 0 2 4.7 CN(C(=O)c1ccccc1)C1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
44295672 195535 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
In vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assay
ChEMBL 439 6 1 3 5.0 COc1cccc(NC(=O)N2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50535 195535 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
In vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assayIn vitro C-C chemokine receptor type 3 receptor activity of compound to inhibit eotaxin induced [Ca2+] mobilization in human eosinophil chemotaxis assay
ChEMBL 439 6 1 3 5.0 COc1cccc(NC(=O)N2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
44452280 102585 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 398 5 1 3 3.9 O=S(=O)(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1 10.1016/j.bmc.2007.10.003
CHEMBL258790 102585 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 398 5 1 3 3.9 O=S(=O)(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1 10.1016/j.bmc.2007.10.003
76313430 110137 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 500 5 1 4 4.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1cnccc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084572 110137 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 500 5 1 4 4.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1cnccc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
76320668 110130 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 471 5 1 4 6.0 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1nccs1 10.1016/j.bmc.2008.08.006
CHEMBL3084565 110130 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 471 5 1 4 6.0 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1nccs1 10.1016/j.bmc.2008.08.006
71451489 88244 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 451 9 3 4 4.5 O=C(Nc1ccccc1OCCCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
CHEMBL2159867 88244 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at CCR3 receptorAntagonist activity at CCR3 receptor
ChEMBL 451 9 3 4 4.5 O=C(Nc1ccccc1OCCCCO)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmcl.2012.09.035
44282047 169946 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 520 9 3 5 4.2 COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)c2cccc3ccccc23)cc1 10.1016/s0960-894x(01)00249-9
CHEMBL418041 169946 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against C-C chemokine receptor type 3Antagonist activity against C-C chemokine receptor type 3
ChEMBL 520 9 3 5 4.2 COc1ccc(NC(=O)[C@H](C)NC(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)c2cccc3ccccc23)cc1 10.1016/s0960-894x(01)00249-9
45273619 203257 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 485 6 1 3 4.8 O=C(/C=C/C1CCN(C(=O)c2ccccc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL563303 203257 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 485 6 1 3 4.8 O=C(/C=C/C1CCN(C(=O)c2ccccc2)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
70688460 82923 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 578 5 2 3 6.1 O=C(Nc1ccc(Br)cc1)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
CHEMBL2057765 82923 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human CCR3Antagonist activity at human CCR3
ChEMBL 578 5 2 3 6.1 O=C(Nc1ccc(Br)cc1)[C@@H]1CCCN1C(=O)NC1C[C@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1 10.1016/j.bmcl.2012.06.042
76313415 113164 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 466 5 1 4 5.4 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1cncnc1 10.1016/j.bmc.2008.08.006
CHEMBL3084359 113164 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 466 5 1 4 5.4 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1cncnc1 10.1016/j.bmc.2008.08.006
CHEMBL3139342 113164 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 466 5 1 4 5.4 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1ccccc1-c1cncnc1 10.1016/j.bmc.2008.08.006
3536 10678 0 None -9 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 assessed as inhibition of CCL11-induced chemotaxis by cell based assayAntagonist activity at CCR3 assessed as inhibition of CCL11-induced chemotaxis by cell based assay
ChEMBL 515 5 1 2 7.3 CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 10.1021/jm300682j
44560289 10678 0 None -9 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 assessed as inhibition of CCL11-induced chemotaxis by cell based assayAntagonist activity at CCR3 assessed as inhibition of CCL11-induced chemotaxis by cell based assay
ChEMBL 515 5 1 2 7.3 CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 10.1021/jm300682j
CHEMBL1186993 10678 0 None -9 2 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 assessed as inhibition of CCL11-induced chemotaxis by cell based assayAntagonist activity at CCR3 assessed as inhibition of CCL11-induced chemotaxis by cell based assay
ChEMBL 515 5 1 2 7.3 CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 10.1021/jm300682j
44451983 166141 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 454 6 1 3 6.2 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1Oc1ccccc1 10.1016/j.bmc.2007.10.003
CHEMBL410041 166141 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 454 6 1 3 6.2 O=C(NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1)c1ccccc1Oc1ccccc1 10.1016/j.bmc.2007.10.003
44452198 164751 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 388 5 1 2 4.8 O=C(/C=C/c1ccccc1)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
CHEMBL408486 164751 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influxAntagonist activity at CCR3 expressed in B300-19 cells assessed as inhibition of eotaxin-induced calcium influx
ChEMBL 388 5 1 2 4.8 O=C(/C=C/c1ccccc1)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2007.10.003
44452198 164751 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 388 5 1 2 4.8 O=C(/C=C/c1ccccc1)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2009.06.066
CHEMBL408486 164751 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium fluxAntagonist activity at human CCR3 expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium flux
ChEMBL 388 5 1 2 4.8 O=C(/C=C/c1ccccc1)NC1CCN(Cc2ccc3cc(F)ccc3c2)CC1 10.1016/j.bmc.2009.06.066
76320669 110135 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 500 5 1 4 4.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1cccnc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
CHEMBL3084570 110135 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometryAntagonist activity at CCR3 receptor expressed in mouse B300-19 cells assessed as inhibition of eotaxin-induced calcium influx by spectrophotometry
ChEMBL 500 5 1 4 4.9 O=C(N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc2cc(F)ccc2c1)c1cccnc1C(=O)N1CCCCC1 10.1016/j.bmc.2008.08.006
11753159 7335 6 None 4 2 Human 7.0 pKd = 7 Functional
Antagonist activity at CCR3 receptor in human polymorphonuclear leukocytes assessed as inhibition of eotaxin-induced CD11b expression after 15 mins by flow cytometric analysisAntagonist activity at CCR3 receptor in human polymorphonuclear leukocytes assessed as inhibition of eotaxin-induced CD11b expression after 15 mins by flow cytometric analysis
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2012.08.124
7679 7335 6 None 4 2 Human 7.0 pKd = 7 Functional
Antagonist activity at CCR3 receptor in human polymorphonuclear leukocytes assessed as inhibition of eotaxin-induced CD11b expression after 15 mins by flow cytometric analysisAntagonist activity at CCR3 receptor in human polymorphonuclear leukocytes assessed as inhibition of eotaxin-induced CD11b expression after 15 mins by flow cytometric analysis
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2012.08.124
CHEMBL2158814 7335 6 None 4 2 Human 7.0 pKd = 7 Functional
Antagonist activity at CCR3 receptor in human polymorphonuclear leukocytes assessed as inhibition of eotaxin-induced CD11b expression after 15 mins by flow cytometric analysisAntagonist activity at CCR3 receptor in human polymorphonuclear leukocytes assessed as inhibition of eotaxin-induced CD11b expression after 15 mins by flow cytometric analysis
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2012.08.124
16040671 88054 0 None - 0 Human 7.9 pKd = 7.9 Functional
Antagonist activity at CCR3 in human eosinophils assessed as inhibition of CCL24-induced morphological changes by FACS flow cytometric analysisAntagonist activity at CCR3 in human eosinophils assessed as inhibition of CCL24-induced morphological changes by FACS flow cytometric analysis
ChEMBL 502 8 1 4 5.4 Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158791 88054 0 None - 0 Human 7.9 pKd = 7.9 Functional
Antagonist activity at CCR3 in human eosinophils assessed as inhibition of CCL24-induced morphological changes by FACS flow cytometric analysisAntagonist activity at CCR3 in human eosinophils assessed as inhibition of CCL24-induced morphological changes by FACS flow cytometric analysis
ChEMBL 502 8 1 4 5.4 Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
16681693 89347 1 None - 0 Human 8.7 pKi = 8.7 Functional
Antagonist activity at human CCR3 assessed as inhibition of CCL11-induced calcium influx by cell based assayAntagonist activity at human CCR3 assessed as inhibition of CCL11-induced calcium influx by cell based assay
ChEMBL 487 5 1 5 3.6 Cc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)nn1 10.1021/jm300682j
CHEMBL2178580 89347 1 None - 0 Human 8.7 pKi = 8.7 Functional
Antagonist activity at human CCR3 assessed as inhibition of CCL11-induced calcium influx by cell based assayAntagonist activity at human CCR3 assessed as inhibition of CCL11-induced calcium influx by cell based assay
ChEMBL 487 5 1 5 3.6 Cc1ccc(C(=O)N2CCC(=CC(=O)N[C@@H]3CCN(Cc4ccc5cc(F)ccc5c4)C3)CC2)nn1 10.1021/jm300682j
44399573 74811 0 None - 0 Human 7.0 pKi = 7.0 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 465 6 1 3 5.4 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)C1CCCCC1 10.1016/j.bmcl.2005.04.054
CHEMBL191418 74811 0 None - 0 Human 7.0 pKi = 7.0 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 465 6 1 3 5.4 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)C1CCCCC1 10.1016/j.bmcl.2005.04.054
44399538 74310 0 None - 0 Human 6.8 pKi = 6.8 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 524 7 1 4 5.7 O=C(NCC1CCCN(C2CCN(CCc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL189680 74310 0 None - 0 Human 6.8 pKi = 6.8 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 524 7 1 4 5.7 O=C(NCC1CCCN(C2CCN(CCc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
44399469 172905 0 None - 1 Human 7.6 pKi = 7.6 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL426089 172905 0 None - 1 Human 7.6 pKi = 7.6 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
44399385 74401 0 None - 0 Human 7.5 pKi = 7.5 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 498 6 2 3 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2[nH]ccc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL190436 74401 0 None - 0 Human 7.5 pKi = 7.5 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 498 6 2 3 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2[nH]ccc2c1 10.1016/j.bmcl.2005.04.054
11540776 76236 0 None - 0 Human 7.5 pKi = 7.5 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2cccnc12 10.1016/j.bmcl.2005.04.054
CHEMBL193354 76236 0 None - 0 Human 7.5 pKi = 7.5 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2cccnc12 10.1016/j.bmcl.2005.04.054
44399272 74246 0 None - 0 Human 7.5 pKi = 7.5 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1nccc2ccccc12 10.1016/j.bmcl.2005.04.054
CHEMBL189206 74246 0 None - 0 Human 7.5 pKi = 7.5 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1nccc2ccccc12 10.1016/j.bmcl.2005.04.054
11540776 76236 0 None - 0 Human 7.4 pKi = 7.4 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2cccnc12 10.1016/j.bmcl.2005.04.054
CHEMBL193354 76236 0 None - 0 Human 7.4 pKi = 7.4 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2cccnc12 10.1016/j.bmcl.2005.04.054
44399482 172807 0 None - 0 Human 7.4 pKi = 7.4 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 498 6 2 3 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2[nH]ccc12 10.1016/j.bmcl.2005.04.054
CHEMBL425548 172807 0 None - 0 Human 7.4 pKi = 7.4 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 498 6 2 3 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2[nH]ccc12 10.1016/j.bmcl.2005.04.054
44399443 75955 0 None - 0 Human 6.4 pKi = 6.4 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3cc(Cl)ccc3Cl)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL192584 75955 0 None - 0 Human 6.4 pKi = 6.4 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3cc(Cl)ccc3Cl)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
44399574 74566 0 None - 0 Human 6.4 pKi = 6.4 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3cc(Cl)cc(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL190894 74566 0 None - 0 Human 6.4 pKi = 6.4 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3cc(Cl)cc(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
44399389 134284 0 None - 0 Human 7.3 pKi = 7.3 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 499 6 2 4 5.0 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2[nH]cnc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL366143 134284 0 None - 0 Human 7.3 pKi = 7.3 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 499 6 2 4 5.0 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2[nH]cnc2c1 10.1016/j.bmcl.2005.04.054
44399331 134295 0 None - 0 Human 7.3 pKi = 7.3 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 509 6 1 3 6.3 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ccccc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL366199 134295 0 None - 0 Human 7.3 pKi = 7.3 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 509 6 1 3 6.3 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ccccc2c1 10.1016/j.bmcl.2005.04.054
44399395 74366 0 None - 0 Human 7.3 pKi = 7.3 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 524 6 1 4 6.0 CC1(N2CCCC(CNC(=O)c3ccc4ncccc4c3)C2)CCN(Cc2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2005.04.054
CHEMBL190149 74366 0 None - 0 Human 7.3 pKi = 7.3 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 524 6 1 4 6.0 CC1(N2CCCC(CNC(=O)c3ccc4ncccc4c3)C2)CCN(Cc2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2005.04.054
44399552 74234 0 None - 0 Human 6.3 pKi = 6.3 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 397 5 1 3 3.8 CC(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2005.04.054
CHEMBL189158 74234 0 None - 0 Human 6.3 pKi = 6.3 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 397 5 1 3 3.8 CC(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2005.04.054
44399524 142294 0 None - 0 Human 7.2 pKi = 7.2 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 509 6 1 3 6.3 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2ccccc12 10.1016/j.bmcl.2005.04.054
CHEMBL372868 142294 0 None - 0 Human 7.2 pKi = 7.2 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 509 6 1 3 6.3 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cccc2ccccc12 10.1016/j.bmcl.2005.04.054
44399368 73968 0 None - 0 Human 7.2 pKi = 7.2 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 473 6 1 3 5.4 Cc1ccccc1C(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2005.04.054
CHEMBL187779 73968 0 None - 0 Human 7.2 pKi = 7.2 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 473 6 1 3 5.4 Cc1ccccc1C(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2005.04.054
44399303 74866 0 None - 0 Human 8.1 pKi = 8.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 524 6 1 4 5.9 CC1CN(Cc2ccc(Cl)c(Cl)c2)CCC1N1CCCC(CNC(=O)c2ccc3ncccc3c2)C1 10.1016/j.bmcl.2005.04.054
CHEMBL191464 74866 0 None - 0 Human 8.1 pKi = 8.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 524 6 1 4 5.9 CC1CN(Cc2ccc(Cl)c(Cl)c2)CCC1N1CCCC(CNC(=O)c2ccc3ncccc3c2)C1 10.1016/j.bmcl.2005.04.054
44399332 76057 0 None - 0 Human 7.1 pKi = 7.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 524 6 1 4 6.2 CC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCC(CNC(=O)c3ccc4ncccc4c3)C2)CC1 10.1016/j.bmcl.2005.04.054
CHEMBL192757 76057 0 None - 0 Human 7.1 pKi = 7.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 524 6 1 4 6.2 CC(c1ccc(Cl)c(Cl)c1)N1CCC(N2CCCC(CNC(=O)c3ccc4ncccc4c3)C2)CC1 10.1016/j.bmcl.2005.04.054
44399290 74386 0 None - 0 Human 6.1 pKi = 6.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 538 6 1 4 5.2 O=C(NCC1CCCN(C2CCN(C(=O)Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL190312 74386 0 None - 0 Human 6.1 pKi = 6.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 538 6 1 4 5.2 O=C(NCC1CCCN(C2CCN(C(=O)Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
44399567 74551 0 None - 0 Human 7.1 pKi = 7.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccnc2ccccc12 10.1016/j.bmcl.2005.04.054
CHEMBL190852 74551 0 None - 0 Human 7.1 pKi = 7.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 510 6 1 4 5.6 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1ccnc2ccccc12 10.1016/j.bmcl.2005.04.054
44399407 74342 0 None - 0 Human 7.1 pKi = 7.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 487 7 1 3 5.3 Cc1ccccc1CC(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2005.04.054
CHEMBL189917 74342 0 None - 0 Human 7.1 pKi = 7.1 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 487 7 1 3 5.3 Cc1ccccc1CC(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2005.04.054
44399442 74428 0 None - 0 Human 7.0 pKi = 7.0 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 489 7 1 4 5.1 COc1ccccc1C(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2005.04.054
CHEMBL190646 74428 0 None - 0 Human 7.0 pKi = 7.0 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 489 7 1 4 5.1 COc1ccccc1C(=O)NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2005.04.054
44399537 74393 0 None - 0 Human 7.0 pKi = 7.0 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 476 6 1 4 5.0 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)cc3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
CHEMBL190362 74393 0 None - 0 Human 7.0 pKi = 7.0 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 476 6 1 4 5.0 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)cc3)CC2)C1)c1ccc2ncccc2c1 10.1016/j.bmcl.2005.04.054
44399479 74356 0 None - 0 Human 7.0 pKi = 7 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 511 6 1 5 5.0 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cnnc2ccccc12 10.1016/j.bmcl.2005.04.054
CHEMBL190048 74356 0 None - 0 Human 7.0 pKi = 7 Functional
In vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligandIn vitro binding activity against C-C chemokine receptor type 3 using [35S]GTP-gamma-S, as radioligand
ChEMBL 511 6 1 5 5.0 O=C(NCC1CCCN(C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C1)c1cnnc2ccccc12 10.1016/j.bmcl.2005.04.054
3536 10678 0 None -9 2 Human 7.0 pIC50 = 7.0 Functional
Measuring antagonism of CCL11-induced chemotaxis <i>in vitro</i>.Measuring antagonism of CCL11-induced chemotaxis <i>in vitro</i>.
Guide to Pharmacology 515 5 1 2 7.3 CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 10854442
44560289 10678 0 None -9 2 Human 7.0 pIC50 = 7.0 Functional
Measuring antagonism of CCL11-induced chemotaxis <i>in vitro</i>.Measuring antagonism of CCL11-induced chemotaxis <i>in vitro</i>.
Guide to Pharmacology 515 5 1 2 7.3 CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 10854442
CHEMBL1186993 10678 0 None -9 2 Human 7.0 pIC50 = 7.0 Functional
Measuring antagonism of CCL11-induced chemotaxis <i>in vitro</i>.Measuring antagonism of CCL11-induced chemotaxis <i>in vitro</i>.
Guide to Pharmacology 515 5 1 2 7.3 CC[N+]1(CCC(CC1)NC(=O)C1c2cc(Cl)ccc2Oc2c1cc(Cl)cc2)CC1CCCCCC1 10854442
4382 7620 0 None 25 2 Human 7.5 pIC50 = 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23951310
9680 8679 6 None - 1 Human 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 450 7 3 4 2.8 O=C(NCc1ccc(cc1)C(=O)N)NC[C@H]1OCCN(C1)Cc1ccc(c(c1)Cl)Cl 22931505
9825034 8679 6 None - 1 Human 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 450 7 3 4 2.8 O=C(NCc1ccc(cc1)C(=O)N)NC[C@H]1OCCN(C1)Cc1ccc(c(c1)Cl)Cl 22931505
CHEMBL2178574 8679 6 None - 1 Human 8.0 pIC50 = 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 450 7 3 4 2.8 O=C(NCc1ccc(cc1)C(=O)N)NC[C@H]1OCCN(C1)Cc1ccc(c(c1)Cl)Cl 22931505
776 7640 0 None -1 2 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10488147
776 7640 0 None -1 2 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15207250
776 7640 0 None -1 2 Human 8.4 pIC50 = 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16339911
754 7617 0 None 5 2 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9346309
775 7637 0 None 316 2 Human 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15207250
775 7637 0 None 316 2 Human 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16339911
769 7613 0 None 14 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10488147
769 7613 0 None 14 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10854442
769 7613 0 None 14 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12761559
769 7613 0 None 14 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16339911
769 7613 0 None 14 3 Human 8.9 pIC50 = 8.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9276730
770 7615 0 None 7 2 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16339911
770 7615 0 None 7 2 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9276730
773 8718 0 None -12 2 Human 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9789057
10098735 10116 0 None - 1 Human 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 537 10 2 5 6.1 COc1cc(NC(=O)N[C@H](C(C)C)CN2CCC(CC2)Cc2ccc(c(c2)Cl)Cl)cc(c1OC)OC 12070060
789 10116 0 None - 1 Human 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 537 10 2 5 6.1 COc1cc(NC(=O)N[C@H](C(C)C)CN2CCC(CC2)Cc2ccc(c(c2)Cl)Cl)cc(c1OC)OC 12070060
11556309 10892 0 None - 1 Human 7.9 pIC50 None 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 502 5 2 5 3.9 O=C(C=C1CCN(CC1)C(=O)c1ncc(cc1O)C)N[C@@H]1CCN(C1)Cc1ccc2c(c1)ccc(c2)F 16339911
793 10892 0 None - 1 Human 7.9 pIC50 None 7.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 502 5 2 5 3.9 O=C(C=C1CCN(CC1)C(=O)c1ncc(cc1O)C)N[C@@H]1CCN(C1)Cc1ccc2c(c1)ccc(c2)F 16339911
788 9272 0 None - 1 Human 8.2 pIC50 None 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10640766
10304110 10122 0 None - 1 Human 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 560 11 2 7 5.3 COc1cc(ccc1OC)c1cnc(nc1)SCC(=O)NCC[C@H]1NC[C@@H](C1)Cc1ccc(c(c1)Cl)Cl 12070060
792 10122 0 None - 1 Human 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 560 11 2 7 5.3 COc1cc(ccc1OC)c1cnc(nc1)SCC(=O)NCC[C@H]1NC[C@@H](C1)Cc1ccc(c(c1)Cl)Cl 12070060
10255622 10120 0 None - 1 Human 8.4 pIC50 None 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 505 10 3 6 4.2 COc1cc(NC(=O)N[C@H](C(O)C)CN2CCC(CC2)Cc2ccc(cc2)Cl)cc(c1OC)OC 12070060
791 10120 0 None - 1 Human 8.4 pIC50 None 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 505 10 3 6 4.2 COc1cc(NC(=O)N[C@H](C(O)C)CN2CCC(CC2)Cc2ccc(cc2)Cl)cc(c1OC)OC 12070060
790 10117 0 None - 1 Human 9.0 pIC50 None 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 552 10 2 4 6.3 COc1cc(NC(=O)N[C@H](C(C)C)C[N+]2(C)CCC(CC2)Cc2ccc(c(c2)Cl)Cl)cc(c1OC)OC 12070060
9915610 10117 0 None - 1 Human 9.0 pIC50 None 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 552 10 2 4 6.3 COc1cc(NC(=O)N[C@H](C(C)C)C[N+]2(C)CCC(CC2)Cc2ccc(c(c2)Cl)Cl)cc(c1OC)OC 12070060


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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ity		 Common
name		 GPCRdb
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selectivity		 # Tested
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 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
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Type		 Assay
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38347547 153233 5 None - 0 Human 5.9 pEC50 = 5.9 Binding
Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay
ChEMBL 430 11 0 7 4.5 C=CCc1cc(OC)c(O[C@@H](C)[C@H](OC(C)=O)c2ccc(OC)c(OC)c2)c(OC)c1 10.1021/acs.jnatprod.6b00262
CHEMBL3922119 153233 5 None - 0 Human 5.9 pEC50 = 5.9 Binding
Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay
ChEMBL 430 11 0 7 4.5 C=CCc1cc(OC)c(O[C@@H](C)[C@H](OC(C)=O)c2ccc(OC)c(OC)c2)c(OC)c1 10.1021/acs.jnatprod.6b00262
25751147 156739 3 None - 0 Human 5.8 pEC50 = 5.8 Binding
Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay
ChEMBL 404 10 2 7 3.7 C=CCc1cc(OC)c(O[C@H](C)[C@@H](O)c2cc(OC)c(O)c(OC)c2)c(OC)c1 10.1021/acs.jnatprod.6b00262
CHEMBL3949874 156739 3 None - 0 Human 5.8 pEC50 = 5.8 Binding
Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay
ChEMBL 404 10 2 7 3.7 C=CCc1cc(OC)c(O[C@H](C)[C@@H](O)c2cc(OC)c(O)c(OC)c2)c(OC)c1 10.1021/acs.jnatprod.6b00262
124396489 151242 6 None - 0 Human 5.8 pEC50 = 5.8 Binding
Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay
ChEMBL 356 5 1 5 4.7 C/C=C/c1cc(OC)c2c(c1)[C@@H](C)[C@H](c1cc(OC)c(O)c(OC)c1)O2 10.1021/acs.jnatprod.6b00262
CHEMBL3906647 151242 6 None - 0 Human 5.8 pEC50 = 5.8 Binding
Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay
ChEMBL 356 5 1 5 4.7 C/C=C/c1cc(OC)c2c(c1)[C@@H](C)[C@H](c1cc(OC)c(O)c(OC)c1)O2 10.1021/acs.jnatprod.6b00262
10474776 120434 42 None - 0 Human 6.1 pEC50 = 6.1 Binding
Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1021/acs.jnatprod.6b00262
CHEMBL33227 120434 42 None - 0 Human 6.1 pEC50 = 6.1 Binding
Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assayAntagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs by PicoGreen dsDNA reagent-based assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1021/acs.jnatprod.6b00262
11272103 131153 0 None - 0 Rat 11.0 pIC50 = 11 Binding
Inhibition of eotaxin-induced chemotaxis of rat eosinophilsInhibition of eotaxin-induced chemotaxis of rat eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL363840 131153 0 None - 0 Rat 11.0 pIC50 = 11 Binding
Inhibition of eotaxin-induced chemotaxis of rat eosinophilsInhibition of eotaxin-induced chemotaxis of rat eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
44570583 197721 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 550 7 2 8 3.3 CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
CHEMBL505914 197721 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 550 7 2 8 3.3 CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
CHEMBL518571 197721 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 550 7 2 8 3.3 CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
44570583 197721 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 550 7 2 8 3.3 CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
CHEMBL505914 197721 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 550 7 2 8 3.3 CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
CHEMBL518571 197721 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 550 7 2 8 3.3 CN1CC(C)(NC(=O)Nc2cccc(-c3nnnn3C)c2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
44593547 183645 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 538 10 2 8 3.3 CCN(CCCc1ccc(F)cc1)CC1OC(=O)N(C)CC1(C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2008.11.002
CHEMBL461445 183645 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 538 10 2 8 3.3 CCN(CCCc1ccc(F)cc1)CC1OC(=O)N(C)CC1(C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2008.11.002
44447136 101327 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 469 11 3 7 2.8 CCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL251837 101327 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 469 11 3 7 2.8 CCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44447381 101666 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 511 12 3 7 3.8 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)CCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254095 101666 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 511 12 3 7 3.8 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)CCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44447137 160932 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 483 12 3 7 3.2 CCCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL398548 160932 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 483 12 3 7 3.2 CCCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44570537 184938 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 536 7 2 8 2.9 CN1C[C@@H](NC(=O)Nc2cccc(-c3nnnn3C)c2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
CHEMBL464902 184938 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 536 7 2 8 2.9 CN1C[C@@H](NC(=O)Nc2cccc(-c3nnnn3C)c2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
10050884 161431 14 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2008.11.002
CHEMBL399495 161431 14 None - 0 Human 9.5 pIC50 = 9.5 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2008.11.002
44447143 101363 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 469 11 4 7 2.7 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CNCCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL252035 101363 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 469 11 4 7 2.7 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CNCCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
10050884 161431 14 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.087
CHEMBL399495 161431 14 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.087
44447144 175551 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 483 11 3 7 3.0 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL437396 175551 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 483 11 3 7 3.0 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
10050884 161431 14 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
CHEMBL399495 161431 14 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
44455658 174052 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 8 3 5 4.4 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nccn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL429323 174052 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 8 3 5 4.4 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nccn2C)c1 10.1016/j.bmcl.2007.11.067
11488078 85776 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113077 85776 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44593553 185146 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 489 6 2 6 3.9 Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1016/j.bmcl.2008.11.002
CHEMBL465272 185146 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 489 6 2 6 3.9 Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1016/j.bmcl.2008.11.002
44447139 101328 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 495 12 3 7 3.2 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC1CC1 10.1016/j.bmcl.2007.11.087
CHEMBL251838 101328 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 495 12 3 7 3.2 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC1CC1 10.1016/j.bmcl.2007.11.087
44447135 101451 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 455 10 3 7 2.5 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)CCCc1ccc(F)cc1 10.1016/j.bmcl.2007.11.087
CHEMBL252631 101451 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 455 10 3 7 2.5 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)CCCc1ccc(F)cc1 10.1016/j.bmcl.2007.11.087
44447361 101728 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 453 9 4 8 1.8 C[C@@H]([C@@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254503 101728 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 453 9 4 8 1.8 C[C@@H]([C@@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44447138 161596 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 481 11 3 7 3.0 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)C1CC1 10.1016/j.bmcl.2007.11.087
CHEMBL400378 161596 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 481 11 3 7 3.0 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)C1CC1 10.1016/j.bmcl.2007.11.087
44447382 173392 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 497 12 3 7 3.4 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL428062 173392 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 497 12 3 7 3.4 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)CCCc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
10050884 161431 14 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3/CCR2 chimeric receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3/CCR2 chimeric receptor in CHO cells
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.087
CHEMBL399495 161431 14 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I] eotaxin from human CCR3/CCR2 chimeric receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3/CCR2 chimeric receptor in CHO cells
ChEMBL 481 8 3 7 2.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.087
44455841 162224 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 509 9 3 7 3.8 CC(C)[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL403838 162224 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 509 9 3 7 3.8 CC(C)[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11328714 85773 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113074 85773 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44593547 183645 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 538 10 2 8 3.3 CCN(CCCc1ccc(F)cc1)CC1OC(=O)N(C)CC1(C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2008.11.002
CHEMBL461445 183645 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 538 10 2 8 3.3 CCN(CCCc1ccc(F)cc1)CC1OC(=O)N(C)CC1(C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2008.11.002
44419331 89549 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 453 9 3 4 4.7 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL217987 89549 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 453 9 3 4 4.7 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
25032958 101323 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 481 10 4 8 2.4 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)[C@@H](C)[C@@H](O)c2ccccc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL251822 101323 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 481 10 4 8 2.4 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(C)[C@@H](C)[C@@H](O)c2ccccc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44447145 101752 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 511 13 3 7 3.8 CCCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cc(CC)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254676 101752 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 511 13 3 7 3.8 CCCN(CCCc1ccc(F)cc1)C[C@H](O)[C@@H](C)NC(=O)Nc1cc(CC)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44455744 102206 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 495 8 3 7 3.5 Cc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL257029 102206 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 495 8 3 7 3.5 Cc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455817 161957 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 538 9 3 8 3.6 CNC(=O)O[C@H](C[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)N1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
CHEMBL402331 161957 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 538 9 3 8 3.6 CNC(=O)O[C@H](C[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)N1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
44455788 162397 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 536 10 2 7 4.3 CCc1cc(NC(=O)N[C@H](C)C[C@@H](N(C)C)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL404585 162397 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 536 10 2 7 4.3 CCc1cc(NC(=O)N[C@H](C)C[C@@H](N(C)C)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11329244 77891 11 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]eotaxin binding to human eosinophilsInhibition of [125I]eotaxin binding to human eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
CHEMBL195433 77891 11 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]eotaxin binding to human eosinophilsInhibition of [125I]eotaxin binding to human eosinophils
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
11272103 131153 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]eotaxin binding to human eosinophilsInhibition of [125I]eotaxin binding to human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL363840 131153 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Inhibition of [125I]eotaxin binding to human eosinophilsInhibition of [125I]eotaxin binding to human eosinophils
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
6918497 120207 2 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(03)00748-0
CHEMBL277930 120207 2 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(03)00748-0
CHEMBL331897 120207 2 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(03)00748-0
6918497 120207 2 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(01)00176-7
CHEMBL277930 120207 2 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(01)00176-7
CHEMBL331897 120207 2 None - 0 Human 9.2 pIC50 = 9.2 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1016/s0960-894x(01)00176-7
6918497 120207 2 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against I-Eotaxin binding to human CCR3 receptorsInhibitory activity against I-Eotaxin binding to human CCR3 receptors
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL277930 120207 2 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against I-Eotaxin binding to human CCR3 receptorsInhibitory activity against I-Eotaxin binding to human CCR3 receptors
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL331897 120207 2 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory activity against I-Eotaxin binding to human CCR3 receptorsInhibitory activity against I-Eotaxin binding to human CCR3 receptors
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
11236950 101539 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 479 9 2 6 4.3 CN(CCCc1ccc(F)cc1)C[C@@H]1CCCC[C@H]1NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL253210 101539 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 479 9 2 6 4.3 CN(CCCc1ccc(F)cc1)C[C@@H]1CCCC[C@H]1NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44447146 101753 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 509 12 3 7 3.5 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)C2CC2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254677 101753 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 509 12 3 7 3.5 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)C2CC2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44447147 101780 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 523 13 3 7 3.8 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)CC2CC2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254881 101780 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 523 13 3 7 3.8 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)CC2CC2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44445886 100994 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 544 7 3 6 3.9 CNC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL249857 100994 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 544 7 3 6 3.9 CNC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
44455844 104191 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 509 10 3 7 4.0 CCC[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL269933 104191 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 509 10 3 7 4.0 CCC[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455791 162398 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 522 9 3 7 3.3 CC(=O)N[C@H](C[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)N1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
CHEMBL404586 162398 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 522 9 3 7 3.3 CC(=O)N[C@H](C[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)N1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1016/j.bmcl.2007.11.067
44289927 175106 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL43423 175106 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
11698698 130018 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 481 8 2 6 4.2 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3cccc(Cl)c3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL361369 130018 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 481 8 2 6 4.2 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3cccc(Cl)c3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44289927 175106 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL43423 175106 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
44390955 130468 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 493 8 2 6 4.3 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CCC2(C)C)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL362179 130468 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 493 8 2 6 4.3 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CCC2(C)C)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44419344 148551 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 495 11 2 4 5.9 CCCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL386073 148551 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 495 11 2 4 5.9 CCCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
11272103 131153 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
CHEMBL363840 131153 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
44445865 161633 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 544 7 3 6 3.9 CNC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL400589 161633 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 544 7 3 6 3.9 CNC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
44455461 162401 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 551 10 3 7 4.2 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)C(=O)O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL404618 162401 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 551 10 3 7 4.2 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)C(=O)O)c1 10.1016/j.bmcl.2007.11.067
44390838 135288 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL366710 135288 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
11398022 105407 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 10.1021/jm049530m
CHEMBL277131 105407 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 10.1021/jm049530m
11272103 131153 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL363840 131153 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
11397114 140247 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2cn[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL3706810 140247 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2cn[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
10459751 106949 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 533 9 2 10 2.7 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.01.059
CHEMBL288009 106949 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 533 9 2 10 2.7 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.01.059
44289701 107883 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 508 9 3 7 2.8 CNC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.01.059
CHEMBL295081 107883 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 508 9 3 7 2.8 CNC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.01.059
44455793 102002 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 483 9 3 5 4.4 CC(=O)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL256068 102002 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 483 9 3 5 4.4 CC(=O)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
44455625 104366 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 565 9 3 7 6.2 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nccs2)cc(-c2nccs2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL270806 104366 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 565 9 3 7 6.2 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nccs2)cc(-c2nccs2)c1 10.1016/j.bmcl.2007.11.067
11227406 101120 2 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of [125I]eotaxin binding to human eosinophilsInhibition of [125I]eotaxin binding to human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL250689 101120 2 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of [125I]eotaxin binding to human eosinophilsInhibition of [125I]eotaxin binding to human eosinophils
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
44419295 89990 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 497 11 3 5 4.4 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCO)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL218568 89990 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 497 11 3 5 4.4 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCO)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
44419298 144917 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 509 11 2 5 5.0 CC(=O)CN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL376737 144917 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 509 11 2 5 5.0 CC(=O)CN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
11329244 77891 11 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL195433 77891 11 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445863 101230 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 559 9 2 7 3.7 COCC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL251275 101230 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 559 9 2 7 3.7 COCC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
44445872 101288 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 533 9 2 6 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CCF)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251622 101288 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 533 9 2 6 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CCF)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445868 173754 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 567 9 2 7 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(Cc3ccco3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL428761 173754 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 567 9 2 7 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(Cc3ccco3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
11329244 77891 11 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
CHEMBL195433 77891 11 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1021/jm049530m
11156406 131949 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL364508 131949 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44290100 185400 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 481 9 3 7 3.0 Cn1nnnc1-c1cc(CO)cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL46747 185400 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 481 9 3 7 3.0 Cn1nnnc1-c1cc(CO)cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
44419345 89929 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 493 11 2 4 5.6 C=CCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL218262 89929 0 None - 0 Human 9.0 pIC50 = 9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 493 11 2 4 5.6 C=CCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
11272103 131153 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.087
CHEMBL363840 131153 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.087
44445842 162356 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 488 7 2 6 4.3 CC(=O)c1sc(NC(=O)N[C@@H]2COCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL404416 162356 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 488 7 2 6 4.3 CC(=O)c1sc(NC(=O)N[C@@H]2COCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455686 102267 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 523 9 3 7 4.3 CC(C)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL257293 102267 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 523 9 3 7 4.3 CC(C)c1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455871 104322 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 495 9 3 7 3.6 CC[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL270583 104322 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 495 9 3 7 3.6 CC[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11272103 131153 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL363840 131153 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
44455511 161806 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 9 2 6 4.0 CCc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL401545 161806 0 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 9 2 6 4.0 CCc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44295462 195188 0 None - 0 Human 9.0 pIC50 = 9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 519 12 3 7 4.3 CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50194 195188 0 None - 0 Human 9.0 pIC50 = 9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 519 12 3 7 4.3 CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/s0960-894x(02)00206-8
44295536 195214 0 None - 0 Human 9.0 pIC50 = 9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 479 12 3 4 5.3 CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50233 195214 0 None - 0 Human 9.0 pIC50 = 9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 479 12 3 4 5.3 CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
9892753 23272 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 516 8 3 4 5.5 CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm049530m
CHEMBL123611 23272 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 516 8 3 4 5.5 CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm049530m
11213416 140249 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2nc[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL3706812 140249 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2nc[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11169258 147675 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 587 8 2 10 3.8 Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1021/jm049530m
CHEMBL382108 147675 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 587 8 2 10 3.8 Cn1nnnc1-c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1021/jm049530m
11966688 19144 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 518 7 2 4 6.0 CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2C[N+]2(C)CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 10.1021/jm0201767
CHEMBL1185532 19144 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 518 7 2 4 6.0 CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2C[N+]2(C)CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 10.1021/jm0201767
CHEMBL419599 19144 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 518 7 2 4 6.0 CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2C[N+]2(C)CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 10.1021/jm0201767
9892753 23272 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 516 8 3 4 5.5 CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL123611 23272 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 516 8 3 4 5.5 CNC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
11730796 123606 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 499 7 3 4 5.2 CNC(=O)c1cccc(NC(=O)Nc2cccc(C#N)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL337962 123606 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 499 7 3 4 5.2 CNC(=O)c1cccc(NC(=O)Nc2cccc(C#N)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
44570617 185155 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 531 7 2 7 4.1 CC(=O)c1sc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2008.11.002
CHEMBL465291 185155 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 531 7 2 7 4.1 CC(=O)c1sc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2008.11.002
44445885 175787 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 558 8 3 6 4.3 CCNC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL439253 175787 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 558 8 3 6 4.3 CCNC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
44455483 104605 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 537 10 3 7 3.8 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)(C)C(=O)O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL272068 104605 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 537 10 3 7 3.8 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)(C)C(=O)O)c1 10.1016/j.bmcl.2007.11.067
44455458 174236 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 533 9 3 7 5.3 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2ccon2)cc(-c2ccon2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL429846 174236 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 533 9 3 7 5.3 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2ccon2)cc(-c2ccon2)c1 10.1016/j.bmcl.2007.11.067
44400941 75639 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 426 6 3 3 3.9 O=C(NC1C=CC=CN1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL192240 75639 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 426 6 3 3 3.9 O=C(NC1C=CC=CN1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11409583 76557 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 507 8 2 4 5.9 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1021/jm049530m
CHEMBL193575 76557 0 None - 0 Human 9.0 pIC50 = 9.0 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 507 8 2 4 5.9 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1021/jm049530m
44445901 166986 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 501 7 2 6 4.2 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2008.11.002
CHEMBL410959 166986 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 501 7 2 6 4.2 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2008.11.002
44447375 101545 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 527 12 4 8 2.8 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)[C@@H](O)Cc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL253244 101545 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 527 12 4 8 2.8 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)[C@@H](O)Cc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44445854 100858 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 522 7 2 7 3.3 CC(=O)c1sc(NC(=O)N[C@@H]2CS(=O)(=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249057 100858 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 522 7 2 7 3.3 CC(=O)c1sc(NC(=O)N[C@@H]2CS(=O)(=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445891 101195 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 533 9 2 6 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CCF)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251044 101195 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 533 9 2 6 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CCF)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445915 162208 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 599 8 2 7 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C3CCOCC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL403742 162208 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 599 8 2 7 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C3CCOCC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445888 162438 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 526 8 2 7 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC#N)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL404857 162438 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 526 8 2 7 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC#N)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445901 166986 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 501 7 2 6 4.2 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL410959 166986 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 501 7 2 6 4.2 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455818 102216 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 523 10 3 7 4.2 CC(C)C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL257073 102216 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 523 10 3 7 4.2 CC(C)C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455510 102365 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 8 2 6 4.2 Cc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL257737 102365 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 8 2 6 4.2 Cc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455790 102497 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 480 8 3 7 3.2 C[C@H](C[C@@H](N)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL258322 102497 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 480 8 3 7 3.2 C[C@H](C[C@@H](N)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44289926 184338 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 453 9 2 4 4.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL46404 184338 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 453 9 2 4 4.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
44390883 70848 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.8 CCc1cc(NC(=O)N[C@@H]2CCCN(CCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL180746 70848 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.8 CCc1cc(NC(=O)N[C@@H]2CCCN(CCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
11167549 85775 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 480 6 2 4 6.1 O=C(Nc1ccc2ncsc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113076 85775 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 480 6 2 4 6.1 O=C(Nc1ccc2ncsc2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44290018 173483 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 465 9 2 6 4.0 CCn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL42826 173483 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 465 9 2 6 4.0 CCn1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
44289741 177509 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 519 8 2 6 4.5 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2004.01.059
CHEMBL44522 177509 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 519 8 2 6 4.5 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2004.01.059
44289926 184338 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 453 9 2 4 4.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2004.01.059
CHEMBL46404 184338 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 453 9 2 4 4.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2004.01.059
44419296 148228 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 511 12 3 5 4.8 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCCO)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL384199 148228 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 511 12 3 5 4.8 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCCO)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
44445884 100992 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 559 9 2 7 3.7 COCC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL249855 100992 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 559 9 2 7 3.7 COCC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
44445867 101067 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 526 8 2 7 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CC#N)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL250437 101067 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 526 8 2 7 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CC#N)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
16747712 161632 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(C)=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL400588 161632 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(C)=O)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445870 174043 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 543 9 2 7 4.1 CC(=O)CN1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL429303 174043 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 543 9 2 7 4.1 CC(=O)CN1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
44455539 173761 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 465 8 2 6 3.9 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL428775 173761 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 465 8 2 6 3.9 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
10096657 71628 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 479 8 2 6 3.9 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2C)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL182086 71628 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 479 8 2 6 3.9 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2C)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
11306550 85778 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 497 6 3 3 6.0 O=C(Nc1ccc2[nH]nc(Cl)c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113079 85778 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 497 6 3 3 6.0 O=C(Nc1ccc2[nH]nc(Cl)c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44419328 90083 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 411 8 3 3 4.5 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
CHEMBL219048 90083 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 411 8 3 3 4.5 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
44445895 101224 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 584 8 2 7 4.7 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C3CCN(C)CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251220 101224 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 584 8 2 7 4.7 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C3CCN(C)CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455482 104604 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 533 9 3 9 3.2 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2ccnn2)cc(-n2ccnn2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL272067 104604 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 533 9 3 9 3.2 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2ccnn2)cc(-n2ccnn2)c1 10.1016/j.bmcl.2007.11.067
11363005 67280 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL175634 67280 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11442162 77443 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 444 6 2 4 5.2 Cc1csc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1021/jm049530m
CHEMBL195044 77443 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 444 6 2 4 5.2 Cc1csc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1021/jm049530m
11454941 77917 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cc1nnnn1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL195555 77917 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 505 7 2 6 4.7 Cc1nnnn1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
44445864 101257 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 558 8 3 6 4.3 CCNC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL251446 101257 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 558 8 3 6 4.3 CCNC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
44445916 162209 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 599 8 2 7 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C3CCOCC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL403743 162209 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 599 8 2 7 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C3CCOCC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455820 102217 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 551 11 3 7 4.9 CCC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL257074 102217 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 551 11 3 7 4.9 CCC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 10.1016/j.bmcl.2007.11.067
44455869 104321 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 507 9 2 7 4.1 CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL270582 104321 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 507 9 2 7 4.1 CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44289715 177014 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 465 8 2 6 3.8 Cc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL444568 177014 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 465 8 2 6 3.8 Cc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11340670 134012 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 483 7 2 3 5.8 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F 10.1021/jm049530m
CHEMBL365820 134012 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 483 7 2 3 5.8 CC(=O)c1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)ccc1F 10.1021/jm049530m
44289715 177014 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 465 8 2 6 3.8 Cc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.01.059
CHEMBL444568 177014 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 465 8 2 6 3.8 Cc1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.01.059
44445887 100995 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 572 9 2 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)CN(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249858 100995 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 572 9 2 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)CN(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445866 161742 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 572 9 2 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)CN(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL401159 161742 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 572 9 2 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)CN(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455847 162225 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 501 9 2 6 4.7 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL403839 162225 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 501 9 2 6 4.7 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
10322255 69301 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL178230 69301 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44390945 69723 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 507 9 2 6 4.5 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2C(C)C)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL178503 69723 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 507 9 2 6 4.5 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2C(C)C)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
11154845 67491 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 6 2 2 5.8 Cc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL176077 67491 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 6 2 2 5.8 Cc1ccccc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11454015 140250 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2cc[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL3706813 140250 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2cc[nH]c2c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
16126667 89841 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 425 8 2 3 4.9 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2C)c1 10.1016/j.bmcl.2006.08.012
CHEMBL218174 89841 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 425 8 2 3 4.9 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2C)c1 10.1016/j.bmcl.2006.08.012
44445839 162299 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 488 7 2 6 4.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCO[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL404213 162299 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 488 7 2 6 4.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCO[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455846 104236 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 515 9 2 6 5.1 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL270147 104236 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 515 9 2 6 5.1 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
44455765 162139 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 543 8 2 6 4.6 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(Br)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL403331 162139 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 543 8 2 6 4.6 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(Br)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11751629 85779 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 464 6 3 3 5.4 O=C(Nc1ccc2c(c1)CCN2)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113080 85779 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 464 6 3 3 5.4 O=C(Nc1ccc2c(c1)CCN2)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
10458976 101786 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 509 9 3 7 3.4 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254930 101786 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 509 9 3 7 3.4 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44445873 161743 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 572 9 2 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CC(=O)N(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL401160 161743 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 572 9 2 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CC(=O)N(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455766 102460 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 8 2 6 4.3 C[C@H](C[C@@H](C)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL258156 102460 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 8 2 6 4.3 C[C@H](C[C@@H](C)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455745 162080 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 559 8 3 7 4.0 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(Br)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL402983 162080 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 559 8 3 7 4.0 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(Br)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455711 175512 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 509 9 3 7 3.8 CCc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL437031 175512 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 509 9 3 7 3.8 CCc1cc(NC(=O)N[C@H](C)C[C@@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44390938 69729 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 483 8 2 6 3.8 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3F)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL178506 69729 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 483 8 2 6 3.8 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3F)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
11351206 76198 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 441 6 2 2 5.6 O=C(Nc1ccccc1F)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL193330 76198 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 441 6 2 2 5.6 O=C(Nc1ccccc1F)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11477384 140248 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 490 6 3 2 6.6 Cc1[nH]c2cc(NC(=O)N[C@@H]3CCCC[C@H]3CN3CCC[C@@H](Cc4ccc(F)cc4)C3)ccc2c1C 10.1021/jm049530m
CHEMBL3706811 140248 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 490 6 3 2 6.6 Cc1[nH]c2cc(NC(=O)N[C@@H]3CCCC[C@H]3CN3CCC[C@@H](Cc4ccc(F)cc4)C3)ccc2c1C 10.1021/jm049530m
44419301 90857 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 491 10 2 4 5.1 C#CCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL220765 90857 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 491 10 2 4 5.1 C#CCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
11953409 100991 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249854 100991 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445845 101017 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 487 7 3 6 3.8 CC(=O)c1sc(NC(=O)N[C@@H]2CCNC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL250056 101017 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 487 7 3 6 3.8 CC(=O)c1sc(NC(=O)N[C@@H]2CCNC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44390837 70322 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 479 9 2 6 4.0 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL180042 70322 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 479 9 2 6 4.0 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
11419003 77683 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 430 6 2 4 4.9 O=C(Nc1nccs1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL195129 77683 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 430 6 2 4 4.9 O=C(Nc1nccs1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44401328 77871 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL195348 77871 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 462 6 3 2 5.9 O=C(Nc1ccc2[nH]ccc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 10.1021/jm049530m
11373714 133952 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 427 6 2 4 4.2 Cn1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1021/jm049530m
CHEMBL365732 133952 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 427 6 2 4 4.2 Cn1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1021/jm049530m
9680 8679 6 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 450 7 3 4 2.8 O=C(NCc1ccc(cc1)C(=O)N)NC[C@H]1OCCN(C1)Cc1ccc(c(c1)Cl)Cl 10.1021/jm300682j
9825034 8679 6 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 450 7 3 4 2.8 O=C(NCc1ccc(cc1)C(=O)N)NC[C@H]1OCCN(C1)Cc1ccc(c(c1)Cl)Cl 10.1021/jm300682j
CHEMBL2178574 8679 6 None - 0 Human 8.0 pIC50 = 8 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 450 7 3 4 2.8 O=C(NCc1ccc(cc1)C(=O)N)NC[C@H]1OCCN(C1)Cc1ccc(c(c1)Cl)Cl 10.1021/jm300682j
22393282 107983 0 None - 1 Human 8.0 pIC50 = 8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL295832 107983 0 None - 1 Human 8.0 pIC50 = 8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
22393282 107983 0 None - 1 Human 8.0 pIC50 = 8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
CHEMBL295832 107983 0 None - 1 Human 8.0 pIC50 = 8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
11385178 131585 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 441 6 2 2 5.6 O=C(Nc1cccc(F)c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL364263 131585 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 441 6 2 2 5.6 O=C(Nc1cccc(F)c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
22393282 107983 0 None - 1 Human 8.0 pIC50 = 8 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL295832 107983 0 None - 1 Human 8.0 pIC50 = 8 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.01.059
44440398 100108 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 584 8 0 5 6.3 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(C2CCCCC2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL245310 100108 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 584 8 0 5 6.3 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(C2CCCCC2)n1C 10.1016/j.bmcl.2007.05.035
44440420 100307 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 608 9 0 6 5.8 COc1ccc(-n2c(=O)c(CN(CCc3ccc(Cl)cc3)C3CCN(C(=O)c4c(F)cccc4F)CC3)c(C)n2C)cc1 10.1016/j.bmcl.2007.05.035
CHEMBL246347 100307 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 608 9 0 6 5.8 COc1ccc(-n2c(=O)c(CN(CCc3ccc(Cl)cc3)C3CCN(C(=O)c4c(F)cccc4F)CC3)c(C)n2C)cc1 10.1016/j.bmcl.2007.05.035
44440424 156039 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 621 9 0 6 5.8 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(N(C)C)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL394443 156039 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 621 9 0 6 5.8 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(N(C)C)cc2)n1C 10.1016/j.bmcl.2007.05.035
44440426 156042 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 613 8 0 6 5.8 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2cnccc2Cl)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL394444 156042 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 613 8 0 6 5.8 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2cnccc2Cl)n1C 10.1016/j.bmcl.2007.05.035
44440411 156869 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2cccc(F)c2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL395090 156869 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2cccc(F)c2)n1C 10.1016/j.bmcl.2007.05.035
44440414 157802 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 594 8 1 6 5.5 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(O)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL395851 157802 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 594 8 1 6 5.5 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(O)cc2)n1C 10.1016/j.bmcl.2007.05.035
44440417 157805 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 623 9 0 7 5.7 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc([N+](=O)[O-])cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL395852 157805 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 623 9 0 7 5.7 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc([N+](=O)[O-])cc2)n1C 10.1016/j.bmcl.2007.05.035
44295264 194254 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 435 8 2 3 5.6 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(-c2ccco2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL49404 194254 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 435 8 2 3 5.6 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(-c2ccco2)c1 10.1016/s0960-894x(02)00206-8
44295664 195474 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 435 10 2 3 5.5 CCC[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50423 195474 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 435 10 2 3 5.5 CCC[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
44295405 195860 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 435 8 3 3 4.7 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(-c2ncc[nH]2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50988 195860 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 435 8 3 3 4.7 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(-c2ncc[nH]2)c1 10.1016/s0960-894x(02)00206-8
22393436 196089 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 375 7 2 2 4.1 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NC1CCCCC1 10.1016/s0960-894x(02)00206-8
CHEMBL51229 196089 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 375 7 2 2 4.1 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NC1CCCCC1 10.1016/s0960-894x(02)00206-8
44295567 197432 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 465 10 3 4 4.7 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@H](O)C(C)C)c1 10.1016/s0960-894x(02)00206-8
CHEMBL51815 197432 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 465 10 3 4 4.7 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@H](O)C(C)C)c1 10.1016/s0960-894x(02)00206-8
9979012 86577 0 None - 0 Human 6.0 pIC50 = 6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 411 7 1 5 4.4 O=C(CSc1nc2ccccc2s1)NCC1CCCN(Cc2ccccc2)C1 10.1016/s0960-894x(01)00176-7
CHEMBL21199 86577 0 None - 0 Human 6.0 pIC50 = 6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 411 7 1 5 4.4 O=C(CSc1nc2ccccc2s1)NCC1CCCN(Cc2ccccc2)C1 10.1016/s0960-894x(01)00176-7
44273640 105704 0 None - 0 Human 6.0 pIC50 = 6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 417 7 1 5 4.8 O=C(CSc1nc2ccccc2s1)NCC1CCCN(CC2CCCCC2)C1 10.1016/s0960-894x(01)00176-7
CHEMBL279450 105704 0 None - 0 Human 6.0 pIC50 = 6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 417 7 1 5 4.8 O=C(CSc1nc2ccccc2s1)NCC1CCCN(CC2CCCCC2)C1 10.1016/s0960-894x(01)00176-7
57401421 74640 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 486 6 1 3 5.1 O=C(NCCCN1CCC(c2ccc(F)cc2)CC1)C1=Cc2cc(Br)ccc2OCC1 10.1016/j.bmcl.2011.09.013
CHEMBL1910161 74640 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 486 6 1 3 5.1 O=C(NCCCN1CCC(c2ccc(F)cc2)CC1)C1=Cc2cc(Br)ccc2OCC1 10.1016/j.bmcl.2011.09.013
44440435 100214 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 563 8 0 6 4.6 Cc1c(CN(CCc2ccccn2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL245956 100214 0 None - 0 Human 6.0 pIC50 = 6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 563 8 0 6 4.6 Cc1c(CN(CCc2ccccn2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
44295529 194079 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 368 8 1 2 4.3 O=C(NCCCCN1CCC(Cc2ccccc2)CC1)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL49296 194079 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 368 8 1 2 4.3 O=C(NCCCCN1CCC(Cc2ccccc2)CC1)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
44349617 124896 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 336 4 0 2 4.0 Fc1ccc(CCCN2CCC3C(C2)c2cccc4c2N3CC4)cc1 10.1021/jm0201767
CHEMBL340770 124896 0 None - 0 Human 6.0 pIC50 = 6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 336 4 0 2 4.0 Fc1ccc(CCCN2CCC3C(C2)c2cccc4c2N3CC4)cc1 10.1021/jm0201767
5481702 212602 1 None - 0 Human 5.0 pIC50 = 5 Binding
Compound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR3 receptorCompound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR3 receptor
ChEMBL 556 8 0 4 5.3 CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1 10.1016/s0960-894x(00)00639-9
CHEMBL83338 212602 1 None - 0 Human 5.0 pIC50 = 5 Binding
Compound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR3 receptorCompound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR3 receptor
ChEMBL 556 8 0 4 5.3 CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1 10.1016/s0960-894x(00)00639-9
44442590 100547 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells
ChEMBL 606 11 6 5 3.8 Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)C(=O)NC(C)(C)C)c(C)c1 10.1016/j.bmcl.2007.07.028
CHEMBL247455 100547 0 None - 0 Human 5.0 pIC50 = 5 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells
ChEMBL 606 11 6 5 3.8 Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)C(=O)NC(C)(C)C)c(C)c1 10.1016/j.bmcl.2007.07.028
44295435 196432 0 None - 0 Human 5.0 pIC50 = 5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 415 6 1 4 2.7 O=S(=O)(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL51512 196432 0 None - 0 Human 5.0 pIC50 = 5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 415 6 1 4 2.7 O=S(=O)(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
44346194 22320 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 501 9 2 5 5.4 COc1cc(NC(=O)N[C@H](C)CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
CHEMBL121905 22320 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 501 9 2 5 5.4 COc1cc(NC(=O)N[C@H](C)CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
11006582 18228 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 483 6 2 4 5.5 C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL1180359 18228 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 483 6 2 4 5.5 C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL123616 18228 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 483 6 2 4 5.5 C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccccc2)CC1 10.1021/jm0201767
11059789 23544 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 472 7 3 4 5.3 N#Cc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL124438 23544 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 472 7 3 4 5.3 N#Cc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
10983981 23620 1 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 505 8 2 5 5.7 COC(=O)c1cccc(NC(=O)Nc2cccc(OC)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL124821 23620 1 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 505 8 2 5 5.7 COC(=O)c1cccc(NC(=O)Nc2cccc(OC)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
10895831 125191 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 461 8 2 3 6.0 COc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL341074 125191 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 461 8 2 3 6.0 COc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
44295486 108276 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 502 5 2 3 4.0 O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)Nc1cccc(I)c1 10.1016/s0960-894x(02)00206-8
CHEMBL297945 108276 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 502 5 2 3 4.0 O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)Nc1cccc(I)c1 10.1016/s0960-894x(02)00206-8
20576924 196018 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 364 5 0 3 4.0 O=C(CCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL51163 196018 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 364 5 0 3 4.0 O=C(CCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
45270199 203197 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Inhibition of mouse CCR3Inhibition of mouse CCR3
ChEMBL 516 5 1 4 4.2 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1cc[n+]([O-])cc1C(=O)N1CCCCC1 10.1016/j.bmc.2009.06.066
CHEMBL562897 203197 0 None - 0 Mouse 6.0 pIC50 = 6.0 Binding
Inhibition of mouse CCR3Inhibition of mouse CCR3
ChEMBL 516 5 1 4 4.2 O=C(NC1CC2CCC(C1)N2Cc1ccc2cc(F)ccc2c1)c1cc[n+]([O-])cc1C(=O)N1CCCCC1 10.1016/j.bmc.2009.06.066
44295408 195578 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 381 6 1 3 3.7 O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)C1CCCCC1 10.1016/s0960-894x(02)00206-8
CHEMBL50591 195578 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 381 6 1 3 3.7 O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)C1CCCCC1 10.1016/s0960-894x(02)00206-8
11101888 120083 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 421 5 2 2 6.0 O=C(Nc1cc(F)ccc1F)Nc1ccccc1CN1CCC(c2ccccc2)CC1 10.1021/jm0201767
CHEMBL331530 120083 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 421 5 2 2 6.0 O=C(Nc1cc(F)ccc1F)Nc1ccccc1CN1CCC(c2ccccc2)CC1 10.1021/jm0201767
10983308 24749 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 454 7 3 4 5.1 N#Cc1cccc(NC(=O)Nc2cc(CO)ccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL126174 24749 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 454 7 3 4 5.1 N#Cc1cccc(NC(=O)Nc2cc(CO)ccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
57392726 74646 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 490 8 0 5 4.2 COc1ccc(OC)c(S(=O)(=O)N2CCC(CN3CCC(Cc4ccc(F)cc4)CC3)CC2)c1 10.1016/j.bmcl.2011.09.013
CHEMBL1910167 74646 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 490 8 0 5 4.2 COc1ccc(OC)c(S(=O)(=O)N2CCC(CN3CCC(Cc4ccc(F)cc4)CC3)CC2)c1 10.1016/j.bmcl.2011.09.013
44346153 22275 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 519 8 3 5 4.1 C[C@H](O)[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 10.1016/s0960-894x(03)00748-0
CHEMBL121637 22275 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 519 8 3 5 4.1 C[C@H](O)[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 10.1016/s0960-894x(03)00748-0
44346154 175440 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorCompound was tested for its ability to inhibit C-C chemokine receptor type 3 receptor
ChEMBL 489 7 2 4 4.7 C[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 10.1016/s0960-894x(03)00748-0
CHEMBL436363 175440 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorCompound was tested for its ability to inhibit C-C chemokine receptor type 3 receptor
ChEMBL 489 7 2 4 4.7 C[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 10.1016/s0960-894x(03)00748-0
44440437 153241 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 600 9 0 8 4.9 Cc1ccnc(C)c1C(=O)N1CCC(N(CCc2ccc([N+](=O)[O-])cc2)Cc2c(C)n(C)n(-c3ccc(F)cc3)c2=O)CC1 10.1016/j.bmcl.2007.05.035
CHEMBL392218 153241 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 600 9 0 8 4.9 Cc1ccnc(C)c1C(=O)N1CCC(N(CCc2ccc([N+](=O)[O-])cc2)Cc2c(C)n(C)n(-c3ccc(F)cc3)c2=O)CC1 10.1016/j.bmcl.2007.05.035
23657036 153242 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 572 9 0 8 4.3 Cc1c(CN(CCc2ccc([N+](=O)[O-])cc2)C2CCN(C(=O)c3ccccn3)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL392219 153242 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 572 9 0 8 4.3 Cc1c(CN(CCc2ccc([N+](=O)[O-])cc2)C2CCN(C(=O)c3ccccn3)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
44390848 129168 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3cccc(F)c3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL360062 129168 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3cccc(F)c3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
9868532 67261 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
CHEMBL175502 67261 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
11396995 77077 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 459 6 2 2 5.7 O=C(Nc1ccc(F)c(F)c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL194384 77077 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 459 6 2 2 5.7 O=C(Nc1ccc(F)c(F)c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44387837 130610 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 448 6 2 3 5.3 N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
CHEMBL362465 130610 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 448 6 2 3 5.3 N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
44419303 148625 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 517 11 2 4 5.7 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(F)F)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL386493 148625 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 517 11 2 4 5.7 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(F)F)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
44390843 70953 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 477 9 2 7 3.5 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(OC)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL180860 70953 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 477 9 2 7 3.5 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(OC)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44295374 108368 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 404 9 2 3 4.8 N#Cc1cccc(NC(=O)NCCCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL298681 108368 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 404 9 2 3 4.8 N#Cc1cccc(NC(=O)NCCCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
44295352 195463 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 380 9 1 3 4.2 COc1cccc(C(=O)NCCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50400 195463 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 380 9 1 3 4.2 COc1cccc(C(=O)NCCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
44295372 195942 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 419 7 2 2 5.2 O=C(NCCCN1CCC(Cc2ccccc2)CC1)Nc1ccc(C(F)(F)F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL51113 195942 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 419 7 2 2 5.2 O=C(NCCCN1CCC(Cc2ccccc2)CC1)Nc1ccc(C(F)(F)F)cc1 10.1016/s0960-894x(02)00206-8
10623381 23674 0 None - 1 Human 4.9 pIC50 = 4.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 448 8 2 3 5.3 NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL125111 23674 0 None - 1 Human 4.9 pIC50 = 4.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 448 8 2 3 5.3 NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
44349204 23980 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 350 5 0 2 3.8 CC1C2=C(CC=CC2)C(=O)N1CC1CCN(CCc2ccccc2)CC1 10.1021/jm0201767
CHEMBL125643 23980 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 350 5 0 2 3.8 CC1C2=C(CC=CC2)C(=O)N1CC1CCN(CCc2ccccc2)CC1 10.1021/jm0201767
11037869 23495 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 459 7 2 3 6.1 CC(=O)c1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
CHEMBL124317 23495 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 459 7 2 3 6.1 CC(=O)c1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
11037869 23495 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 459 7 2 3 6.1 CC(=O)c1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL124317 23495 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 459 7 2 3 6.1 CC(=O)c1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
44419314 90076 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 376 7 3 3 4.1 N#Cc1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
CHEMBL218997 90076 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 376 7 3 3 4.1 N#Cc1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
44593553 185146 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 489 6 2 6 3.9 Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1016/j.bmcl.2008.11.002
CHEMBL465272 185146 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 489 6 2 6 3.9 Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1016/j.bmcl.2008.11.002
44390891 70748 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 7 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NC[C@H]2CCCN(CCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL180694 70748 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 7 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NC[C@H]2CCCN(CCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
44295544 195709 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 375 8 1 3 4.0 N#Cc1ccc(C(=O)NCCCCN2CCC(Cc3ccccc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL50801 195709 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 375 8 1 3 4.0 N#Cc1ccc(C(=O)NCCCCN2CCC(Cc3ccccc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
11826382 24044 1 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 443 8 2 3 5.5 COc1ccc(NC(=O)NCc2ccccc2CN2CCC(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
CHEMBL125695 24044 1 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 443 8 2 3 5.5 COc1ccc(NC(=O)NCc2ccccc2CN2CCC(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
44419305 89406 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 535 10 2 4 6.0 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(F)(F)F)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL217928 89406 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 535 10 2 4 6.0 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(F)(F)F)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
44390867 69353 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 451 7 2 6 3.4 CCc1cc(NC(=O)N[C@@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL178278 69353 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 451 7 2 6 3.4 CCc1cc(NC(=O)N[C@@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
11396851 67271 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
CHEMBL175559 67271 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
11247999 84745 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL2096763 84745 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
10972522 23902 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 456 7 2 3 5.8 N#Cc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL125549 23902 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 456 7 2 3 5.8 N#Cc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
11004663 124380 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 438 7 2 3 5.7 N#Cc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL340080 124380 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 438 7 2 3 5.7 N#Cc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
10917990 23266 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 491 7 2 5 5.7 COc1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 10.1021/jm0201767
CHEMBL123580 23266 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 491 7 2 5 5.7 COc1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 10.1021/jm0201767
11729258 23617 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 409 8 0 3 5.1 N#CC(CCCN1CCN(Cc2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL124808 23617 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 409 8 0 3 5.1 N#CC(CCCN1CCN(Cc2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
44419323 90910 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 390 8 3 3 4.5 N#Cc1cccc(NC(=O)NCCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
CHEMBL220800 90910 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 390 8 3 3 4.5 N#Cc1cccc(NC(=O)NCCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
11609863 23618 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 343 6 1 2 4.6 OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccccc2)CC1 10.1021/jm0201767
CHEMBL124813 23618 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 343 6 1 2 4.6 OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccccc2)CC1 10.1021/jm0201767
44390851 130637 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NC[C@H]2CCCN(CCCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL362613 130637 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NC[C@H]2CCCN(CCCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
44442599 100424 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells
ChEMBL 585 9 5 5 3.3 Cc1cc(Br)ccc1CNC[C@H](NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1N)C(=O)NC(C)(C)C 10.1016/j.bmcl.2007.07.028
CHEMBL246804 100424 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells
ChEMBL 585 9 5 5 3.3 Cc1cc(Br)ccc1CNC[C@H](NC(=O)CNC(=O)c1cccc(C(F)(F)F)c1N)C(=O)NC(C)(C)C 10.1016/j.bmcl.2007.07.028
44295145 198376 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 502 5 2 3 4.0 O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)Nc1ccc(I)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL51953 198376 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 502 5 2 3 4.0 O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)Nc1ccc(I)cc1 10.1016/s0960-894x(02)00206-8
11059385 165176 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 448 8 1 2 5.6 O=C(Cc1ccc(F)cc1)Nc1ccccc1CCN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL409001 165176 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 448 8 1 2 5.6 O=C(Cc1ccc(F)cc1)Nc1ccccc1CCN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
44440419 100306 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 603 8 0 6 5.6 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(C#N)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL246346 100306 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 603 8 0 6 5.6 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(C#N)cc2)n1C 10.1016/j.bmcl.2007.05.035
44440393 100691 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 586 10 0 5 6.8 Cc1c(CN(CCCCc2ccccc2)C2CCN(C(=O)c3cccc4ccccc34)CC2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL248178 100691 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 586 10 0 5 6.8 Cc1c(CN(CCCCc2ccccc2)C2CCN(C(=O)c3cccc4ccccc34)CC2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2007.05.035
44445851 161360 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 573 7 2 7 5.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)C[C@@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL399133 161360 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 573 7 2 7 5.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)C[C@@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44295354 195940 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 394 8 2 3 4.2 CN(C)c1ccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL51110 195940 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 394 8 2 3 4.2 CN(C)c1ccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
23509664 201725 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 421 6 1 3 4.9 COc1cccc(NC(=O)N2CCC(CN3CCC(Cc4ccccc4)CC3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL54251 201725 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 421 6 1 3 4.9 COc1cccc(NC(=O)N2CCC(CN3CCC(Cc4ccccc4)CC3)CC2)c1 10.1016/s0960-894x(02)00206-8
9907041 174608 2 None - 0 Human 4.8 pIC50 = 4.8 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 363 7 2 5 2.2 CCOC(=O)[C@H](Cc1ccc(O)cc1)NS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(01)00248-7
CHEMBL430745 174608 2 None - 0 Human 4.8 pIC50 = 4.8 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 363 7 2 5 2.2 CCOC(=O)[C@H](Cc1ccc(O)cc1)NS(=O)(=O)c1ccc(C)cc1 10.1016/s0960-894x(01)00248-7
10974378 121074 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 664 12 3 4 7.4 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)NC1CCN(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL333063 121074 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 664 12 3 4 7.4 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)NC1CCN(Cc2ccccc2)CC1 10.1021/jm0201767
71458114 86391 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 4.9 CC(=O)c1cccc(NC(=O)NCCCN2CC3CCC2[C@@H](Cc2ccc(F)cc2)C3)c1 10.1016/j.bmcl.2004.01.059
CHEMBL2114958 86391 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 4.9 CC(=O)c1cccc(NC(=O)NCCCN2CC3CCC2[C@@H](Cc2ccc(F)cc2)C3)c1 10.1016/j.bmcl.2004.01.059
10983419 124239 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 461 7 3 3 5.6 O=C(Nc1ccccc1)Nc1cccc(C(=O)O)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL339884 124239 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 461 7 3 3 5.6 O=C(Nc1ccccc1)Nc1cccc(C(=O)O)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
44295480 196389 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 439 6 1 3 5.2 COc1cccc(NC(=O)N2CCCCC2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL51480 196389 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 439 6 1 3 5.2 COc1cccc(NC(=O)N2CCCCC2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
20613253 120119 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 446 7 1 2 6.4 Cc1ccc(C(=O)NC(CC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
CHEMBL331702 120119 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 446 7 1 2 6.4 Cc1ccc(C(=O)NC(CC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
44281525 116480 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 314 6 2 5 1.7 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccn1 10.1016/s0960-894x(01)00248-7
CHEMBL32282 116480 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 314 6 2 5 1.7 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccn1 10.1016/s0960-894x(01)00248-7
10928228 23567 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 435 6 2 2 6.1 O=C(Nc1cc(F)ccc1F)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL124583 23567 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 435 6 2 2 6.1 O=C(Nc1cc(F)ccc1F)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
10874167 177621 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 457 7 2 4 5.2 O=C(NCc1ccc2c(c1)OCO2)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL445379 177621 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 457 7 2 4 5.2 O=C(NCc1ccc2c(c1)OCO2)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
44281789 118127 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 454 8 1 5 4.8 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)OCc1ccccc1)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL32692 118127 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 454 8 1 5 4.8 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)OCc1ccccc1)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
11026634 120108 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 443 8 2 3 5.8 COc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL331634 120108 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 443 8 2 3 5.8 COc1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
22022826 23221 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 472 7 1 2 6.5 Cc1ccc(C(=O)NC(CN2C3CCC2CC(Cc2ccc(Cl)c(Cl)c2)C3)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
CHEMBL123308 23221 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 472 7 1 2 6.5 Cc1ccc(C(=O)NC(CN2C3CCC2CC(Cc2ccc(Cl)c(Cl)c2)C3)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
44419322 91149 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 362 6 3 3 3.7 N#Cc1cccc(NC(=O)NCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
CHEMBL221901 91149 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 362 6 3 3 3.7 N#Cc1cccc(NC(=O)NCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
15907328 170142 34 None - 0 Human 4.7 pIC50 = 4.7 Binding
Evaluated for its inhibitory activity against human Chemokine receptor type 3 expressed in chinese hamster ovary cellsEvaluated for its inhibitory activity against human Chemokine receptor type 3 expressed in chinese hamster ovary cells
ChEMBL 301 3 1 2 3.8 OC1(c2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL419244 170142 34 None - 0 Human 4.7 pIC50 = 4.7 Binding
Evaluated for its inhibitory activity against human Chemokine receptor type 3 expressed in chinese hamster ovary cellsEvaluated for its inhibitory activity against human Chemokine receptor type 3 expressed in chinese hamster ovary cells
ChEMBL 301 3 1 2 3.8 OC1(c2ccc(Cl)cc2)CCN(Cc2ccccc2)CC1 10.1021/jm0201767
44447374 101504 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 499 11 4 8 2.2 CCN(C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](C)[C@@H](O)Cc1ccc(F)cc1 10.1016/j.bmcl.2007.11.087
CHEMBL253034 101504 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 499 11 4 8 2.2 CCN(C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](C)[C@@H](O)Cc1ccc(F)cc1 10.1016/j.bmcl.2007.11.087
44289763 171830 0 None - 1 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 412 7 2 3 4.3 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccc(F)cc3F)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL42264 171830 0 None - 1 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 412 7 2 3 4.3 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccc(F)cc3F)C2)c1 10.1016/j.bmcl.2004.01.059
22143196 190766 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of CCR3 at 10 uMInhibition of CCR3 at 10 uM
ChEMBL 509 7 5 6 2.0 CSc1ccc(C(=O)NC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 10.1016/j.bmcl.2008.12.062
CHEMBL481790 190766 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of CCR3 at 10 uMInhibition of CCR3 at 10 uM
ChEMBL 509 7 5 6 2.0 CSc1ccc(C(=O)NC2CCNCC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 10.1016/j.bmcl.2008.12.062
209394 123410 13 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 297 6 1 3 2.6 CCOC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
CHEMBL33693 123410 13 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 297 6 1 3 2.6 CCOC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
11814253 123733 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 635 10 3 3 8.2 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cccc(C(F)(F)F)c1 10.1021/jm0201767
CHEMBL338624 123733 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 635 10 3 3 8.2 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cccc(C(F)(F)F)c1 10.1021/jm0201767
12000105 91017 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 453 10 2 3 5.7 CCCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL221067 91017 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 453 10 2 3 5.7 CCCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
11227406 101120 2 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm300682j
CHEMBL250689 101120 2 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm300682j
11272103 131153 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2008.11.002
CHEMBL363840 131153 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2008.11.002
44445876 100862 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 501 7 2 6 4.2 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249060 100862 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 501 7 2 6 4.2 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445856 101038 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 557 8 2 6 4.7 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL250262 101038 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 557 8 2 6 4.7 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
11227406 101120 2 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
CHEMBL250689 101120 2 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
44445892 101196 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 572 9 2 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC(=O)N(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251045 101196 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 572 9 2 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC(=O)N(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445840 101226 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 488 7 2 6 4.3 CC(=O)c1sc(NC(=O)N[C@@H]2CCOC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251232 101226 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 488 7 2 6 4.3 CC(=O)c1sc(NC(=O)N[C@@H]2CCOC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445894 161510 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 612 8 2 7 4.6 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C3CCN(C(C)=O)CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL399893 161510 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 612 8 2 7 4.6 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C3CCN(C(C)=O)CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
21362425 161782 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 584 8 2 7 4.7 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C3CCN(C)CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL401394 161782 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 584 8 2 7 4.7 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C3CCN(C)CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
11227406 101120 2 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL250689 101120 2 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
44455509 173205 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 493 9 2 6 4.4 CCc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL427728 173205 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 493 9 2 6 4.4 CCc1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455560 176058 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 517 9 2 8 3.8 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2ccnn2)cc(-n2ccnn2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL441334 176058 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 517 9 2 8 3.8 C[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2ccnn2)cc(-n2ccnn2)c1 10.1016/j.bmcl.2007.11.067
11363006 77210 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 10.1021/jm049530m
CHEMBL194601 77210 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1 10.1021/jm049530m
11227406 101120 2 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL250689 101120 2 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
44401123 143058 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 516 7 2 5 4.9 N#CC1=CC(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)CC=C1n1cccn1 10.1021/jm049530m
CHEMBL373347 143058 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 516 7 2 5 4.9 N#CC1=CC(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)CC=C1n1cccn1 10.1021/jm049530m
11017618 18242 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 501 6 2 4 5.7 C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL1180385 18242 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 501 6 2 4 5.7 C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL124689 18242 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 501 6 2 4 5.7 C[N+]1(Cc2cc3c(cc2NC(=O)Nc2cccc(C#N)c2)OCO3)CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
11762511 23335 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 474 7 3 3 5.3 CNC(=O)c1cccc(NC(=O)Nc2ccccc2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL123837 23335 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 474 7 3 3 5.3 CNC(=O)c1cccc(NC(=O)Nc2ccccc2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
11134936 23517 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 504 8 3 4 5.3 CNC(=O)c1cccc(NC(=O)Nc2cccc(OC)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL124334 23517 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 504 8 3 4 5.3 CNC(=O)c1cccc(NC(=O)Nc2cccc(OC)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
11038430 23595 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 502 8 3 4 5.2 CC(=O)c1cccc(NC(=O)Nc2cccc(C(N)=O)c2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL124722 23595 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 502 8 3 4 5.2 CC(=O)c1cccc(NC(=O)Nc2cccc(C(N)=O)c2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
44570581 185195 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 536 10 2 8 3.1 CN1C[C@@H](NC(=O)Nc2cccc(-c3nnnn3C)c2)[C@H](CN(CCCc2ccc(F)cc2)C2CC2)OC1=O 10.1016/j.bmcl.2008.11.002
CHEMBL465942 185195 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 536 10 2 8 3.1 CN1C[C@@H](NC(=O)Nc2cccc(-c3nnnn3C)c2)[C@H](CN(CCCc2ccc(F)cc2)C2CC2)OC1=O 10.1016/j.bmcl.2008.11.002
44445847 101199 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 487 7 3 6 3.8 CC(=O)c1sc(NC(=O)N[C@@H]2CNCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251079 101199 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 487 7 3 6 3.8 CC(=O)c1sc(NC(=O)N[C@@H]2CNCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445878 161377 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 557 8 2 6 4.7 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL399150 161377 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 557 8 2 6 4.7 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445880 162015 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 543 8 2 6 4.5 CCC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL402707 162015 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 543 8 2 6 4.5 CCC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
21362416 100859 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 612 8 2 7 4.6 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C3CCN(C(C)=O)CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249058 100859 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 612 8 2 7 4.6 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C3CCN(C(C)=O)CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44390927 69774 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 493 9 2 6 4.3 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2CC)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL178671 69774 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 493 9 2 6 4.3 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2CC)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44390894 129138 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 479 9 2 6 4.0 CCc1cc(NC(=O)NC[C@H]2CCCN(CCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL360039 129138 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 479 9 2 6 4.0 CCc1cc(NC(=O)NC[C@H]2CCCN(CCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
11179351 131392 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 490 7 2 5 5.0 O=C(Nc1ccc(-n2cncn2)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL364068 131392 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 490 7 2 5 5.0 O=C(Nc1ccc(-n2cncn2)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44419300 90778 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 499 11 2 4 5.4 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCF)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL220713 90778 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 499 11 2 4 5.4 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCF)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
795 7362 5 None - 1 Human 8.6 pIC50 = 8.6 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 10.1016/s0960-894x(03)00748-0
796 7362 5 None - 1 Human 8.6 pIC50 = 8.6 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 10.1016/s0960-894x(03)00748-0
9913085 7362 5 None - 1 Human 8.6 pIC50 = 8.6 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 10.1016/s0960-894x(03)00748-0
CHEMBL20921 7362 5 None - 1 Human 8.6 pIC50 = 8.6 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 10.1016/s0960-894x(03)00748-0
795 7362 5 None - 1 Human 8.6 pIC50 = 8.6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 10.1016/s0960-894x(01)00176-7
796 7362 5 None - 1 Human 8.6 pIC50 = 8.6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 10.1016/s0960-894x(01)00176-7
9913085 7362 5 None - 1 Human 8.6 pIC50 = 8.6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 10.1016/s0960-894x(01)00176-7
CHEMBL20921 7362 5 None - 1 Human 8.6 pIC50 = 8.6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 10.1016/s0960-894x(01)00176-7
44445875 100860 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 531 9 3 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CCO)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249059 100860 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 531 9 3 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CCO)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445859 161565 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 545 7 2 7 4.3 COC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL400173 161565 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 545 7 2 7 4.3 COC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
44401561 130899 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL363373 130899 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 463 6 3 3 5.3 O=C(Nc1ccc2[nH]ncc2c1)N[C@@H]1CCCC[C@H]1CN1CCCC(Cc2ccc(F)cc2)C1 10.1021/jm049530m
11750808 132974 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 431 6 2 5 4.3 O=C(Nc1nncs1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL364977 132974 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 431 6 2 5 4.3 O=C(Nc1nncs1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44346210 174734 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorCompound was tested for its ability to inhibit C-C chemokine receptor type 3 receptor
ChEMBL 531 10 3 6 4.7 COc1cc(NC(=O)N[C@@H](CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)[C@H](C)O)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
CHEMBL431670 174734 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorCompound was tested for its ability to inhibit C-C chemokine receptor type 3 receptor
ChEMBL 531 10 3 6 4.7 COc1cc(NC(=O)N[C@@H](CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)[C@H](C)O)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
44455845 104235 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 537 10 3 7 4.5 CC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL270146 104235 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 537 10 3 7 4.5 CC[C@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2nnnn2C)cc(C(C)(C)O)c1 10.1016/j.bmcl.2007.11.067
44289713 172887 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 527 9 2 6 5.2 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2ccccc2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL42599 172887 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 527 9 2 6 5.2 Cn1nnnc1-c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2ccccc2)c1 10.1016/j.bmcl.2004.01.059
44419335 90916 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 465 10 2 3 5.7 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC2CC2)c1 10.1016/j.bmcl.2006.08.012
CHEMBL220819 90916 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 465 10 2 3 5.7 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC2CC2)c1 10.1016/j.bmcl.2006.08.012
44447140 101329 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 523 11 3 7 4.2 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)C1CCCCC1 10.1016/j.bmcl.2007.11.087
CHEMBL251839 101329 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 523 11 3 7 4.2 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)C1CCCCC1 10.1016/j.bmcl.2007.11.087
44447154 101467 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 559 13 3 7 4.6 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)Cc2ccccc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL252792 101467 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 559 13 3 7 4.6 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)Cc2ccccc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44447380 101665 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 483 11 3 7 3.2 CCN(C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](C)CCc1ccc(F)cc1 10.1016/j.bmcl.2007.11.087
CHEMBL254093 101665 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 483 11 3 7 3.2 CCN(C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](C)CCc1ccc(F)cc1 10.1016/j.bmcl.2007.11.087
44445907 101608 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 409 7 2 3 4.6 CC(=O)c1cccc(NC(=O)N/C=C/CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
CHEMBL253676 101608 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 409 7 2 3 4.6 CC(=O)c1cccc(NC(=O)N/C=C/CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
44445883 162016 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 555 8 2 6 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C3CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL402708 162016 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 555 8 2 6 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C3CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44290039 185581 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL46905 185581 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.11.067
11430170 130611 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 423 6 2 2 5.5 O=C(Nc1ccccc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL362466 130611 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 423 6 2 2 5.5 O=C(Nc1ccccc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11385766 139574 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL370082 139574 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
44290039 185581 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL46905 185581 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
44290039 185581 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL46905 185581 0 None - 1 Human 8.6 pIC50 = 8.6 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
44445849 101227 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 573 7 2 7 5.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251243 101227 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 573 7 2 7 5.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445889 161645 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 567 9 2 7 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CN(Cc3ccco3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL400649 161645 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 567 9 2 7 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CN(Cc3ccco3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44289919 107930 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 493 9 2 7 3.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL295415 107930 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 493 9 2 7 3.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455683 161867 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 531 9 3 7 4.4 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL401879 161867 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 531 9 3 7 4.4 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-n2cccn2)cc(-n2cccn2)c1 10.1016/j.bmcl.2007.11.067
44455485 162277 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 507 9 2 6 5.0 CC(C)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL404122 162277 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 507 9 2 6 5.0 CC(C)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44455484 174185 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 493 9 2 6 4.6 CC(C)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL429604 174185 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 493 9 2 6 4.6 CC(C)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
44387842 138079 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 369 5 2 3 4.2 CC(=O)c1cccc(NC(=O)NN2CCCCC2Cc2ccc(F)cc2)c1 10.1021/jm049530m
CHEMBL368683 138079 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 369 5 2 3 4.2 CC(=O)c1cccc(NC(=O)NN2CCCCC2Cc2ccc(F)cc2)c1 10.1021/jm049530m
10457573 123826 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 473 8 2 3 6.2 CC(=O)c1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL339110 123826 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 473 8 2 3 6.2 CC(=O)c1cccc(NC(=O)Nc2ccccc2CCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
44289919 107930 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 493 9 2 7 3.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.01.059
CHEMBL295415 107930 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 493 9 2 7 3.7 CC(=O)c1cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.01.059
44445893 161191 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 541 9 2 6 5.0 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC3CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL398889 161191 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 541 9 2 6 5.0 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CC3CC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455459 101866 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 467 9 2 4 5.1 CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL255398 101866 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 467 9 2 4 5.1 CC(=O)c1cc(NC(=O)N[C@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
44455460 101867 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 533 9 3 7 5.3 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2ncco2)cc(-c2ncco2)c1 10.1016/j.bmcl.2007.11.067
CHEMBL255399 101867 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 533 9 3 7 5.3 C[C@H](C[C@@H](O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cc(-c2ncco2)cc(-c2ncco2)c1 10.1016/j.bmcl.2007.11.067
44455767 102496 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 483 9 3 5 4.4 CC(=O)c1cc(NC(=O)N[C@@H](C)C[C@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL258309 102496 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 483 9 3 5 4.4 CC(=O)c1cc(NC(=O)N[C@@H](C)C[C@H](O)N2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
11487192 76450 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 428 6 2 4 4.8 Cc1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)no1 10.1021/jm049530m
CHEMBL193526 76450 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 428 6 2 4 4.8 Cc1cc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)no1 10.1021/jm049530m
44445896 161315 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 531 9 3 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CCO)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL399088 161315 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 531 9 3 7 3.6 CC(=O)c1sc(NC(=O)N[C@@H]2CN(CCO)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445855 161564 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 583 8 2 6 5.3 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C3CCCC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL400172 161564 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 583 8 2 6 5.3 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C3CCCC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
11113940 86357 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 509 8 1 6 5.9 CCOc1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1 10.1016/s0960-894x(01)00176-7
CHEMBL21143 86357 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 509 8 1 6 5.9 CCOc1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1 10.1016/s0960-894x(01)00176-7
44440402 100692 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL248179 100692 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
44295648 108777 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 437 9 3 4 4.1 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@H](C)O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL301601 108777 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 437 9 3 4 4.1 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@H](C)O)c1 10.1016/s0960-894x(02)00206-8
44295555 108831 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 447 8 2 4 3.7 CS(=O)(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL301974 108831 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 447 8 2 4 3.7 CS(=O)(=O)c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
22393430 175481 0 None - 1 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL43677 175481 0 None - 1 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
22393339 193515 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 410 7 2 3 4.7 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(Cl)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL48873 193515 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 410 7 2 3 4.7 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(Cl)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
44295306 195662 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 415 8 2 3 5.0 CSc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50726 195662 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 415 8 2 3 5.0 CSc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
22393469 196153 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 394 7 2 3 4.2 N#Cc1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL51286 196153 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 394 7 2 3 4.2 N#Cc1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
44295566 201493 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 479 11 3 4 5.1 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@@H](O)CC(C)C)c1 10.1016/s0960-894x(02)00206-8
CHEMBL53444 201493 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 479 11 3 4 5.1 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@@H](O)CC(C)C)c1 10.1016/s0960-894x(02)00206-8
22393430 175481 0 None - 1 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL43677 175481 0 None - 1 Human 7.7 pIC50 = 7.7 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.01.059
44440429 100418 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 580 8 0 5 5.4 Cc1c(CN(CCc2ccc(F)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL246768 100418 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 580 8 0 5 5.4 Cc1c(CN(CCc2ccc(F)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
44440445 153525 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 577 8 0 6 4.3 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3cccc[n+]3[O-])CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL392430 153525 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 577 8 0 6 4.3 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3cccc[n+]3[O-])CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
44295674 108410 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 483 10 2 3 6.0 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2Cc2ccccc2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL298999 108410 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 483 10 2 3 6.0 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2Cc2ccccc2)c1 10.1016/s0960-894x(02)00206-8
22393362 108466 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 437 7 2 2 5.3 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccccc1C(F)(F)F 10.1016/s0960-894x(02)00206-8
CHEMBL299385 108466 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 437 7 2 2 5.3 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccccc1C(F)(F)F 10.1016/s0960-894x(02)00206-8
9842640 174153 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 376 7 2 3 4.0 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL42948 174153 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 376 7 2 3 4.0 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
44295267 195011 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 431 8 2 3 4.0 C[S+]([O-])c1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL49938 195011 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 431 8 2 3 4.0 C[S+]([O-])c1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
44295406 195143 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 8 2 3 6.0 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(-c2cccs2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50129 195143 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 8 2 3 6.0 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(-c2cccs2)c1 10.1016/s0960-894x(02)00206-8
44295664 195474 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 435 10 2 3 5.5 CCC[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50423 195474 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 435 10 2 3 5.5 CCC[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
22393307 195550 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3F)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50557 195550 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3F)CC2)c1 10.1016/s0960-894x(02)00206-8
44295304 195907 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 9 3 4 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2C(C)(C)O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL51052 195907 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 9 3 4 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2C(C)(C)O)c1 10.1016/s0960-894x(02)00206-8
22393366 199299 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 411 8 2 3 4.5 CC(=O)c1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL52094 199299 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 411 8 2 3 4.5 CC(=O)c1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
9842640 174153 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 376 7 2 3 4.0 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL42948 174153 0 None - 1 Human 6.7 pIC50 = 6.7 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 376 7 2 3 4.0 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/j.bmcl.2004.01.059
44349614 125228 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 402 5 0 3 3.6 O=C1CC2(CCc3ccccc32)C(=O)N1CC1CCN(CCc2ccccc2)CC1 10.1021/jm0201767
CHEMBL341144 125228 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 402 5 0 3 3.6 O=C1CC2(CCc3ccccc32)C(=O)N1CC1CCN(CCc2ccccc2)CC1 10.1021/jm0201767
44281791 123049 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 406 7 1 5 4.0 CC(C)OC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL33589 123049 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 406 7 1 5 4.0 CC(C)OC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
11103845 18898 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 455 6 3 3 5.5 C[N+]1(Cc2cc(O)ccc2NC(=O)Nc2cccc(C#N)c2)CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL1184106 18898 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 455 6 3 3 5.5 C[N+]1(Cc2cc(O)ccc2NC(=O)Nc2cccc(C#N)c2)CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL332591 18898 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 455 6 3 3 5.5 C[N+]1(Cc2cc(O)ccc2NC(=O)Nc2cccc(C#N)c2)CCC(Cc2ccccc2)CC1 10.1021/jm0201767
11812807 23350 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 477 8 3 4 5.5 COc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL123917 23350 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 477 8 3 4 5.5 COc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
44447161 101659 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 547 12 3 8 2.3 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)S(C)(=O)=O)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254055 101659 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 547 12 3 8 2.3 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)S(C)(=O)=O)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44447153 160711 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 617 13 3 7 5.6 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)CC23CC4CC(CC(C4)C2)C3)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL398344 160711 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 617 13 3 7 5.6 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)CC23CC4CC(CC(C4)C2)C3)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44419314 90076 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 376 7 3 3 4.1 N#Cc1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
CHEMBL218997 90076 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 376 7 3 3 4.1 N#Cc1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
11828215 121237 1 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 613 12 3 3 7.1 O=C(NCCc1ccc(F)cc1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL333422 121237 1 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 613 12 3 3 7.1 O=C(NCCc1ccc(F)cc1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
11104005 124138 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 602 12 3 4 6.2 O=C(NCCN1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL339752 124138 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 602 12 3 4 6.2 O=C(NCCN1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
11813735 124923 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 562 12 3 4 5.3 CN(C)CCNC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL340797 124923 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 562 12 3 4 5.3 CN(C)CCNC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
11730610 23457 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 485 7 2 5 5.7 CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccccc4)CC2)OCO3)c1 10.1021/jm0201767
CHEMBL124272 23457 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 485 7 2 5 5.7 CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccccc4)CC2)OCO3)c1 10.1021/jm0201767
44390949 71179 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCC2CCN(CCCc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL181311 71179 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCC2CCN(CCCc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.11.006
44512617 202117 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of mouse CCR3Inhibition of mouse CCR3
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
CHEMBL551735 202117 0 None - 0 Mouse 6.6 pIC50 = 6.6 Binding
Inhibition of mouse CCR3Inhibition of mouse CCR3
ChEMBL 487 5 2 4 4.2 O=C(C=C1CCN(C(=O)c2ccccc2O)CC1)N[C@@H]1CCN(Cc2ccc3cc(F)ccc3c2)C1 10.1016/j.bmc.2009.06.066
44295686 169780 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 407 5 1 3 4.6 COc1cccc(NC(=O)N2CCC(N3CCC(Cc4ccccc4)CC3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL417547 169780 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 407 5 1 3 4.6 COc1cccc(NC(=O)N2CCC(N3CCC(Cc4ccccc4)CC3)CC2)c1 10.1016/s0960-894x(02)00206-8
10995218 23388 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 549 12 4 4 5.1 O=C(NCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL124127 23388 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 549 12 4 4 5.1 O=C(NCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
9982077 23359 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 468 6 2 5 5.4 N#Cc1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccccc4)CC2)OCO3)c1 10.1021/jm0201767
CHEMBL123962 23359 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 468 6 2 5 5.4 N#Cc1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccccc4)CC2)OCO3)c1 10.1021/jm0201767
44447373 101450 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 453 9 4 8 1.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)[C@H](C)[C@@H](O)c1ccccc1 10.1016/j.bmcl.2007.11.087
CHEMBL252628 101450 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 453 9 4 8 1.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)[C@H](C)[C@@H](O)c1ccccc1 10.1016/j.bmcl.2007.11.087
10863252 178135 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 447 7 3 3 5.5 O=C(Nc1ccccc1)Nc1ccccc1C(O)CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL446164 178135 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 447 7 3 3 5.5 O=C(Nc1ccccc1)Nc1ccccc1C(O)CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
44295479 108333 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 425 6 1 3 4.6 COc1cccc(NC(=O)N2CCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL298414 108333 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 425 6 1 3 4.6 COc1cccc(NC(=O)N2CCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
11285792 7666 34 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from CCR3 expressed in CHO cells
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/jm0509703
801 7666 34 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from CCR3 expressed in CHO cells
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/jm0509703
CHEMBL2110727 7666 34 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from CCR3 expressed in CHO cells
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/jm0509703
DB11758 7666 34 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from CCR3 expressed in CHO cells
ChEMBL 696 17 1 7 8.7 CCCCOCCOc1ccc(cc1)c1ccc2c(c1)C=C(CCCN2CC(C)C)C(=O)Nc1ccc(cc1)[S@@](=O)Cc1cncn1CCC 10.1021/jm0509703
10983106 23701 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 443 8 2 3 5.5 COc1cccc(NC(=O)NCc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL125282 23701 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 443 8 2 3 5.5 COc1cccc(NC(=O)NCc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
11124782 125247 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 587 11 3 3 7.3 O=C(NCC1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL341306 125247 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 587 11 3 3 7.3 O=C(NCC1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
22393396 175049 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3cccc(F)c3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL43391 175049 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3cccc(F)c3)C2)c1 10.1016/j.bmcl.2004.01.059
11732727 23422 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 429 7 3 3 5.3 O=C(Nc1ccccc1)Nc1ccccc1C(O)CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL124206 23422 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 429 7 3 3 5.3 O=C(Nc1ccccc1)Nc1ccccc1C(O)CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
44440396 159846 1 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 579 8 0 6 5.2 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccccn2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL397599 159846 1 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 579 8 0 6 5.2 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccccn2)n1C 10.1016/j.bmcl.2007.05.035
44440427 100417 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 609 9 0 7 5.2 COc1ccncc1-n1c(=O)c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(C)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL246766 100417 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 609 9 0 7 5.2 COc1ccncc1-n1c(=O)c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(C)n1C 10.1016/j.bmcl.2007.05.035
44295499 196136 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 453 7 1 3 5.4 COc1cccc(NC(=O)N2CCCC(CCN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL51267 196136 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 453 7 1 3 5.4 COc1cccc(NC(=O)N2CCCC(CCN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
44440422 100308 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 622 9 1 6 5.5 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(C(=O)O)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL246348 100308 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 622 9 1 6 5.5 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(C(=O)O)cc2)n1C 10.1016/j.bmcl.2007.05.035
44440440 100419 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 577 8 1 6 4.8 Cc1c(CN(CCc2ccc(N)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL246769 100419 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 577 8 1 6 4.8 Cc1c(CN(CCc2ccc(N)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
44440434 160142 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 563 8 0 6 4.6 Cc1c(CN(CCc2cccnc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL397853 160142 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 563 8 0 6 4.6 Cc1c(CN(CCc2cccnc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
44295409 108441 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 355 5 1 3 3.2 CC(C)(C)C(=O)NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3 10.1016/s0960-894x(02)00206-8
CHEMBL299226 108441 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 355 5 1 3 3.2 CC(C)(C)C(=O)NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3 10.1016/s0960-894x(02)00206-8
44295433 193839 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 441 6 1 4 4.0 COc1cccc(NC(=O)N2CCO[C@@H](CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL49117 193839 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 441 6 1 4 4.0 COc1cccc(NC(=O)N2CCO[C@@H](CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
23497297 23646 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 483 6 3 5 5.4 O=C(Nc1ccc2c[nH]nc2c1)Nc1cc2c(cc1CN1CCC(Cc3ccccc3)CC1)OCO2 10.1021/jm0201767
CHEMBL124966 23646 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 483 6 3 5 5.4 O=C(Nc1ccc2c[nH]nc2c1)Nc1cc2c(cc1CN1CCC(Cc3ccccc3)CC1)OCO2 10.1021/jm0201767
11001953 120910 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 327 7 2 4 2.2 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Cc1ccccc1 10.1016/s0960-894x(01)00248-7
CHEMBL33290 120910 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 327 7 2 4 2.2 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Cc1ccccc1 10.1016/s0960-894x(01)00248-7
11825113 23659 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 381 8 3 3 3.6 O=C(NCCCO)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL125026 23659 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 381 8 3 3 3.6 O=C(NCCCO)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
11762865 23333 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 503 9 2 2 7.1 O=C(NCC(c1ccccc1)c1ccccc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL123807 23333 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 503 9 2 2 7.1 O=C(NCC(c1ccccc1)c1ccccc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
44570714 196573 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of CCR3 at 10 uMInhibition of CCR3 at 10 uM
ChEMBL 565 9 5 6 3.6 CSc1ccc(C(=O)NC2CCC(NC(C)C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 10.1016/j.bmcl.2008.12.062
CHEMBL516224 196573 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of CCR3 at 10 uMInhibition of CCR3 at 10 uM
ChEMBL 565 9 5 6 3.6 CSc1ccc(C(=O)NC2CCC(NC(C)C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1 10.1016/j.bmcl.2008.12.062
11048458 125256 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 440 6 3 4 5.4 N#Cc1cccc(NC(=O)Nc2ccc(O)cc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL341343 125256 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 440 6 3 4 5.4 N#Cc1cccc(NC(=O)Nc2ccc(O)cc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
71449114 85722 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 435 7 2 3 5.3 COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCCC(Cc3ccccc3)C2)c1 10.1021/jm049530m
CHEMBL2112987 85722 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 435 7 2 3 5.3 COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCCC(Cc3ccccc3)C2)c1 10.1021/jm049530m
10928173 83318 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 431 6 1 5 4.8 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2cccc(Cl)c2)CC1 10.1016/s0960-894x(01)00176-7
CHEMBL20612 83318 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 431 6 1 5 4.8 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2cccc(Cl)c2)CC1 10.1016/s0960-894x(01)00176-7
10950225 124252 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 438 7 2 3 5.3 N#Cc1cccc(NC(=O)NCc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL339934 124252 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 438 7 2 3 5.3 N#Cc1cccc(NC(=O)NCc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
76316987 110312 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 9 2 6 3.9 Cn1nnnc1-c1cccc(NC(=O)NC[C@@H]2CCCN(CCCCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL3085295 110312 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 9 2 6 3.9 Cn1nnnc1-c1cccc(NC(=O)NC[C@@H]2CCCN(CCCCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
11408397 84734 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL2096695 84734 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
22393329 107903 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL295229 107903 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
44390970 70838 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 533 8 2 6 4.4 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2C(F)(F)F)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL180728 70838 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 533 8 2 6 4.4 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2C(F)(F)F)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44390971 129899 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 541 9 2 6 5.0 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2c2ccccc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL361130 129899 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 541 9 2 6 5.0 CCc1cc(NC(=O)NC[C@H]2CN(CCc3ccc(F)cc3)CC[C@@H]2c2ccccc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44387856 138220 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 447 7 2 3 5.5 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm049530m
CHEMBL369073 138220 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 447 7 2 3 5.5 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm049530m
11465468 173816 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
CHEMBL428881 173816 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
44281521 107178 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 370 7 1 5 3.1 CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1ccc(C)cc1C 10.1016/s0960-894x(01)00248-7
CHEMBL290104 107178 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 370 7 1 5 3.1 CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1ccc(C)cc1C 10.1016/s0960-894x(01)00248-7
10255492 124939 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 502 8 3 4 5.2 CC(=O)c1cccc(NC(=O)Nc2ccc(C(N)=O)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL340853 124939 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 502 8 3 4 5.2 CC(=O)c1cccc(NC(=O)Nc2ccc(C(N)=O)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
11733617 168033 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 485 7 3 4 4.9 N#Cc1cccc(NC(=O)Nc2cccc(C(N)=O)c2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL411956 168033 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 485 7 3 4 4.9 N#Cc1cccc(NC(=O)Nc2cccc(C(N)=O)c2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
44289910 107988 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 529 8 2 6 4.2 Cn1nnnc1-c1cc(Br)cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL295898 107988 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 529 8 2 6 4.2 Cn1nnnc1-c1cc(Br)cc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
44290019 107999 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 479 9 2 6 4.5 CC(C)n1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL295970 107999 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 479 9 2 6 4.5 CC(C)n1nnnc1-c1cccc(NC(=O)NCCCN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
44447149 101719 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 551 12 3 7 4.7 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)C2CCCCC2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254470 101719 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 551 12 3 7 4.7 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)C2CCCCC2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44445862 101229 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 555 8 2 6 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C3CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251274 101229 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 555 8 2 6 4.5 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)C3CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44390954 70642 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 483 8 2 6 3.8 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)c(F)c3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL180351 70642 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 483 8 2 6 3.8 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)c(F)c3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44445861 101066 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 543 8 2 6 4.5 CCC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL250436 101066 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 543 8 2 6 4.5 CCC(=O)N1CC[C@@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)[C@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)C1 10.1016/j.bmcl.2007.03.065
44447378 161618 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 527 12 4 8 2.8 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)[C@H](O)Cc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL400467 161618 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 527 12 4 8 2.8 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CC)[C@@H](C)[C@H](O)Cc2ccc(F)cc2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44390838 135288 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL366710 135288 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44419299 148468 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 510 11 3 5 3.9 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(N)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL385607 148468 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 510 11 3 5 3.9 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CC(N)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
11953409 100991 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 mins
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249854 100991 0 None - 0 Mouse 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 mins
ChEMBL 529 7 2 6 4.1 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(C)=O)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44445877 100989 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 583 8 2 6 5.3 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C3CCCC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249851 100989 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 583 8 2 6 5.3 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)C3CCCC3)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44390964 69372 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 481 8 2 6 4.2 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(Cl)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL178287 69372 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 481 8 2 6 4.2 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(Cl)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44289877 172820 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 5 4.3 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cccc(-c2nnco2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL42562 172820 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 5 4.3 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cccc(-c2nnco2)c1 10.1016/j.bmcl.2004.01.059
11213457 101538 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 465 9 3 6 3.9 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CNCCCc2ccc(F)cc2)c1 10.1016/j.bmcl.2007.11.087
CHEMBL253209 101538 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 465 9 3 6 3.9 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CNCCCc2ccc(F)cc2)c1 10.1016/j.bmcl.2007.11.087
44390919 128831 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 447 8 2 6 3.5 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccccc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL359609 128831 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 447 8 2 6 3.5 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccccc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44419306 148165 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 495 9 2 4 5.0 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL383879 148165 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 495 9 2 4 5.0 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
44295434 108345 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 441 6 1 4 4.0 COc1cccc(NC(=O)N2CCO[C@H](CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL298505 108345 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 441 6 1 4 4.0 COc1cccc(NC(=O)N2CCO[C@H](CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
44295362 169000 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 369 7 2 2 4.3 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccccc1 10.1016/s0960-894x(02)00206-8
CHEMBL416305 169000 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 369 7 2 2 4.3 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccccc1 10.1016/s0960-894x(02)00206-8
22393419 172208 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 399 8 2 3 4.3 COc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL42388 172208 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 399 8 2 3 4.3 COc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
23509697 201729 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 440 6 2 4 3.6 COc1cccc(NC(=O)N2CCNC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL54273 201729 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 440 6 2 4 3.6 COc1cccc(NC(=O)N2CCNC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
22393419 172208 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 399 8 2 3 4.3 COc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL42388 172208 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 399 8 2 3 4.3 COc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.01.059
9951883 175471 0 None - 1 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 381 8 2 3 4.2 COc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL43666 175471 0 None - 1 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 381 8 2 3 4.2 COc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
22393378 195740 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 397 9 2 2 4.0 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NCCc1ccccc1 10.1016/s0960-894x(02)00206-8
CHEMBL50829 195740 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 397 9 2 2 4.0 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NCCc1ccccc1 10.1016/s0960-894x(02)00206-8
9951883 175471 0 None - 1 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 381 8 2 3 4.2 COc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL43666 175471 0 None - 1 Human 6.5 pIC50 = 6.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 381 8 2 3 4.2 COc1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/j.bmcl.2004.01.059
11734303 175356 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 547 9 3 3 6.5 CC(C)(C)NC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL435812 175356 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 547 9 3 3 6.5 CC(C)(C)NC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
11396966 85780 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 457 6 2 2 6.1 O=C(Nc1cccc(Cl)c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL2113082 85780 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 457 6 2 2 6.1 O=C(Nc1cccc(Cl)c1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44289762 172714 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 380 7 2 3 3.8 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL42507 172714 0 None - 1 Human 7.5 pIC50 = 7.5 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 380 7 2 3 3.8 N#Cc1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
11059280 123683 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 442 6 2 3 5.8 N#Cc1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL338389 123683 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 442 6 2 3 5.8 N#Cc1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
11037958 82746 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 465 6 1 5 5.5 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 10.1021/jm300682j
CHEMBL20532 82746 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 465 6 1 5 5.5 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 10.1021/jm300682j
11037958 82746 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 465 6 1 5 5.5 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(01)00176-7
CHEMBL20532 82746 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 465 6 1 5 5.5 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(01)00176-7
44440394 100498 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 578 8 0 5 5.8 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL247160 100498 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 578 8 0 5 5.8 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2007.05.035
9927733 123678 1 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 336 6 2 3 3.1 CCOC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
CHEMBL33838 123678 1 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 336 6 2 3 3.1 CCOC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
9888454 108656 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 421 6 1 3 4.9 COc1cccc(NC(=O)N2CCCC(CN3CCC(Cc4ccccc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL300726 108656 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 421 6 1 3 4.9 COc1cccc(NC(=O)N2CCCC(CN3CCC(Cc4ccccc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
44281522 118289 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 391 6 1 4 3.2 CN(C)C(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL32784 118289 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 391 6 1 4 3.2 CN(C)C(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
11133428 23500 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 413 7 2 2 5.5 O=C(NCc1ccccc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL124321 23500 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 413 7 2 2 5.5 O=C(NCc1ccccc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
10863284 25330 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 449 7 2 2 6.1 O=C(Nc1ccc(F)cc1)Nc1ccccc1CCN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL127590 25330 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 449 7 2 2 6.1 O=C(Nc1ccc(F)cc1)Nc1ccccc1CCN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
44390931 129710 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 7 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NCC2CCN(CCc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL360653 129710 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 7 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NCC2CCN(CCc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.11.006
76320703 110313 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 423 6 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NC[C@@H]2CCCN(Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL3085296 110313 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 423 6 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NC[C@@H]2CCCN(Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
10875472 120436 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 568 10 3 4 6.6 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccncc1 10.1021/jm0201767
CHEMBL332277 120436 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 568 10 3 4 6.6 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccncc1 10.1021/jm0201767
9981262 71629 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCC2CCCN(CCCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL182087 71629 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCC2CCCN(CCCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
10874195 171135 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 459 8 3 4 5.3 COc1cccc(NC(=O)Nc2cc(CO)ccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL421273 171135 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 459 8 3 4 5.3 COc1cccc(NC(=O)Nc2cc(CO)ccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
11112528 23585 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 417 6 2 2 5.9 O=C(Nc1ccccc1)Nc1ccccc1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL124669 23585 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 417 6 2 2 5.9 O=C(Nc1ccccc1)Nc1ccccc1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
44295487 175942 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 444 5 2 3 4.5 O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)Nc1ccc(C(F)(F)F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL440477 175942 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 444 5 2 3 4.5 O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)Nc1ccc(C(F)(F)F)cc1 10.1016/s0960-894x(02)00206-8
11145481 120345 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 496 8 2 3 5.9 O=C(Nc1cccc(CN2CCC(Cc3ccccc3)CC2)c1)NC1CCN(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL332227 120345 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 496 8 2 3 5.9 O=C(Nc1cccc(CN2CCC(Cc3ccccc3)CC2)c1)NC1CCN(Cc2ccccc2)CC1 10.1021/jm0201767
22393395 175644 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccccc3F)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL43818 175644 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 394 7 2 3 4.2 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccccc3F)C2)c1 10.1016/j.bmcl.2004.01.059
44390857 70404 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 490 9 2 7 3.6 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(N(C)C)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL180082 70404 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 490 9 2 7 3.6 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(N(C)C)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
10939210 23682 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 445 8 2 2 5.6 O=C(NCCc1ccc(F)cc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL125167 23682 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 445 8 2 2 5.6 O=C(NCCc1ccc(F)cc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
11722772 105361 0 None - 1 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 307 7 0 1 5.0 c1ccc(CCCCN2CCC(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
CHEMBL276784 105361 0 None - 1 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 307 7 0 1 5.0 c1ccc(CCCCN2CCC(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
77033 120572 78 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 313 6 2 4 2.3 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
CHEMBL33242 120572 78 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 313 6 2 4 2.3 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
22966052 90999 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 376 7 3 3 4.1 N#Cc1cccc(NC(=O)NCCC[C@@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
CHEMBL220866 90999 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 376 7 3 3 4.1 N#Cc1cccc(NC(=O)NCCC[C@@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
44289959 107195 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 5.0 CC(=O)c1cccc(NC(=O)NCCCN2CC3(Cc4ccc(F)cc4)CCC2CC3)c1 10.1016/j.bmcl.2004.01.059
CHEMBL290276 107195 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 5.0 CC(=O)c1cccc(NC(=O)NCCCN2CC3(Cc4ccc(F)cc4)CCC2CC3)c1 10.1016/j.bmcl.2004.01.059
44290040 179244 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL44817 179244 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 411 8 2 3 4.5 CC(=O)c1cccc(NC(=O)NCCCN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.01.059
44295259 169334 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 393 6 1 3 3.6 O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL416835 169334 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 393 6 1 3 3.6 O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
9935588 23672 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 496 8 2 3 5.9 O=C(Nc1ccccc1CN1CCC(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL125108 23672 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 496 8 2 3 5.9 O=C(Nc1ccccc1CN1CCC(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1 10.1021/jm0201767
10874991 171137 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 517 9 2 3 6.7 O=C(NCC(c1ccccc1)c1ccccc1)Nc1ccccc1CN1CCC(C(=O)c2ccccc2)CC1 10.1021/jm0201767
CHEMBL421274 171137 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 517 9 2 3 6.7 O=C(NCC(c1ccccc1)c1ccccc1)Nc1ccccc1CN1CCC(C(=O)c2ccccc2)CC1 10.1021/jm0201767
44445874 101289 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 541 9 2 6 5.0 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CC3CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251623 101289 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 541 9 2 6 5.0 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(CC3CC3)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44455792 102498 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 465 8 2 6 3.9 C[C@@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL258323 102498 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 465 8 2 6 3.9 C[C@@H](CCN1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
11214474 78128 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 514 6 2 4 6.7 O=C(Nc1nc2c(Cl)cccc2s1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL195790 78128 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 514 6 2 4 6.7 O=C(Nc1nc2c(Cl)cccc2s1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
11442439 130835 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 455 6 2 2 5.9 Cc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1F 10.1021/jm049530m
CHEMBL363166 130835 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 455 6 2 2 5.9 Cc1ccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc1F 10.1021/jm049530m
9804542 137062 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
CHEMBL367992 137062 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm049530m
44419340 91150 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 451 10 2 3 5.4 C=CCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL221903 91150 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 451 10 2 3 5.4 C=CCN1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
10140602 173397 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 7 2 6 3.4 C[C@H](CC(=O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
CHEMBL428071 173397 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 479 7 2 6 3.4 C[C@H](CC(=O)N1CCC[C@@H](Cc2ccc(F)cc2)C1)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.067
20636465 90864 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 495 9 4 4 4.3 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2C(=N)N)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL220766 90864 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 495 9 4 4 4.3 CC(=O)c1cc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2C(=N)N)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
44346153 22275 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorCompound was tested for its ability to inhibit C-C chemokine receptor type 3 receptor
ChEMBL 519 8 3 5 4.1 C[C@H](O)[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 10.1016/s0960-894x(03)00748-0
CHEMBL121637 22275 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorCompound was tested for its ability to inhibit C-C chemokine receptor type 3 receptor
ChEMBL 519 8 3 5 4.1 C[C@H](O)[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 10.1016/s0960-894x(03)00748-0
11259591 132301 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 455 6 2 2 5.9 Cc1ccc(F)cc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL364673 132301 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 455 6 2 2 5.9 Cc1ccc(F)cc1NC(=O)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44346194 22320 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorCompound was tested for its ability to inhibit C-C chemokine receptor type 3 receptor
ChEMBL 501 9 2 5 5.4 COc1cc(NC(=O)N[C@H](C)CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
CHEMBL121905 22320 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Compound was tested for its ability to inhibit C-C chemokine receptor type 3 receptorCompound was tested for its ability to inhibit C-C chemokine receptor type 3 receptor
ChEMBL 501 9 2 5 5.4 COc1cc(NC(=O)N[C@H](C)CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
44445879 100990 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 545 7 2 7 4.3 COC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL249852 100990 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 545 7 2 7 4.3 COC(=O)N1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
44440412 157800 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccccc2F)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL395850 157800 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 596 8 0 5 5.9 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccccc2F)n1C 10.1016/j.bmcl.2007.05.035
44295554 195123 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 415 8 2 3 5.0 CSc1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL50094 195123 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 415 8 2 3 5.0 CSc1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
23509693 198272 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 540 6 1 5 5.2 COc1cccc(NC(=O)N2CCN(C(=O)OC(C)(C)C)C(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL51937 198272 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 540 6 1 5 5.2 COc1cccc(NC(=O)N2CCN(C(=O)OC(C)(C)C)C(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
10029075 123610 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 503 7 2 5 5.9 CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 10.1021/jm0201767
CHEMBL337990 123610 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 503 7 2 5 5.9 CC(=O)c1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 10.1021/jm0201767
44440423 153488 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 635 9 1 6 5.7 CC(=O)Nc1ccc(-n2c(=O)c(CN(CCc3ccc(Cl)cc3)C3CCN(C(=O)c4c(F)cccc4F)CC3)c(C)n2C)cc1 10.1016/j.bmcl.2007.05.035
CHEMBL392405 153488 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 635 9 1 6 5.7 CC(=O)Nc1ccc(-n2c(=O)c(CN(CCc3ccc(Cl)cc3)C3CCN(C(=O)c4c(F)cccc4F)CC3)c(C)n2C)cc1 10.1016/j.bmcl.2007.05.035
22393428 195433 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 383 8 2 2 4.0 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NCc1ccccc1 10.1016/s0960-894x(02)00206-8
CHEMBL50354 195433 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 383 8 2 2 4.0 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NCc1ccccc1 10.1016/s0960-894x(02)00206-8
22393333 196183 4 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 351 7 2 2 4.2 O=C(NCCCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1 10.1016/s0960-894x(02)00206-8
CHEMBL51307 196183 4 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 351 7 2 2 4.2 O=C(NCCCN1CCC(Cc2ccccc2)CC1)Nc1ccccc1 10.1016/s0960-894x(02)00206-8
44281523 106464 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 453 8 2 4 4.4 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)NCc1ccccc1)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL284577 106464 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 453 8 2 4 4.4 O=C(N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)NCc1ccccc1)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
11282712 85310 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)NC2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1021/jm049530m
CHEMBL2112049 85310 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)NC2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1021/jm049530m
22393315 175461 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 376 7 2 3 4.0 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccccc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL43655 175461 0 None - 1 Human 7.4 pIC50 = 7.4 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 376 7 2 3 4.0 N#Cc1cccc(NC(=O)NCCCN2CCCC(Cc3ccccc3)C2)c1 10.1016/j.bmcl.2004.01.059
11134412 171420 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 465 7 3 3 5.6 O=C(Nc1cc(F)ccc1F)Nc1ccccc1C(O)CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL421634 171420 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 465 7 3 3 5.6 O=C(Nc1cc(F)ccc1F)Nc1ccccc1C(O)CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
10864223 23657 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 517 8 2 5 5.9 COC(=O)c1ccc(NC(=O)Nc2cccc(C(C)=O)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL125012 23657 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 517 8 2 5 5.9 COC(=O)c1ccc(NC(=O)Nc2cccc(C(C)=O)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
44447142 101445 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 589 12 3 7 5.0 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC12CC3CC(CC(C3)C1)C2 10.1016/j.bmcl.2007.11.087
CHEMBL252610 101445 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 589 12 3 7 5.0 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC12CC3CC(CC(C3)C1)C2 10.1016/j.bmcl.2007.11.087
9845853 135253 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 435 7 2 3 5.3 COc1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm049530m
CHEMBL366654 135253 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 435 7 2 3 5.3 COc1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm049530m
44593546 185536 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 531 6 2 6 4.9 CN1CC(C)(NC(=O)Nc2nc(C(C)(C)C)cs2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
CHEMBL468695 185536 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 531 6 2 6 4.9 CN1CC(C)(NC(=O)Nc2nc(C(C)(C)C)cs2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
44445853 161361 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 473 7 3 6 3.5 CC(=O)c1sc(NC(=O)N[C@@H]2CNC[C@@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL399134 161361 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 473 7 3 6 3.5 CC(=O)c1sc(NC(=O)N[C@@H]2CNC[C@@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
11144348 23356 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 424 6 2 3 5.7 N#Cc1cccc(NC(=O)Nc2cccc(CN3CCC(Cc4ccccc4)CC3)c2)c1 10.1021/jm0201767
CHEMBL123957 23356 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 424 6 2 3 5.7 N#Cc1cccc(NC(=O)Nc2cccc(CN3CCC(Cc4ccccc4)CC3)c2)c1 10.1021/jm0201767
11048445 23538 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 439 6 3 3 5.7 O=C(Nc1ccc2[nH]ncc2c1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL124390 23538 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 439 6 3 3 5.7 O=C(Nc1ccc2[nH]ncc2c1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
11091447 176169 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 439 6 3 3 5.7 O=C(Nc1ccc2c[nH]nc2c1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL442210 176169 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 439 6 3 3 5.7 O=C(Nc1ccc2c[nH]nc2c1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
6918497 120207 2 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Inhibitory activity against I-Eotaxin alpha binding to mouse CCR3 receptorsInhibitory activity against I-Eotaxin alpha binding to mouse CCR3 receptors
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL277930 120207 2 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Inhibitory activity against I-Eotaxin alpha binding to mouse CCR3 receptorsInhibitory activity against I-Eotaxin alpha binding to mouse CCR3 receptors
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL331897 120207 2 None - 0 Mouse 6.3 pIC50 = 6.3 Binding
Inhibitory activity against I-Eotaxin alpha binding to mouse CCR3 receptorsInhibitory activity against I-Eotaxin alpha binding to mouse CCR3 receptors
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
10916572 25289 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 408 8 0 2 6.2 N#CC(CCCN1CCC(Cc2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL127395 25289 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 408 8 0 2 6.2 N#CC(CCCN1CCC(Cc2ccccc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
11102400 124872 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 449 6 2 3 5.7 O=C(Nc1cc(F)ccc1F)Nc1ccccc1CN1CCC(C(=O)c2ccccc2)CC1 10.1021/jm0201767
CHEMBL340656 124872 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 449 6 2 3 5.7 O=C(Nc1cc(F)ccc1F)Nc1ccccc1CN1CCC(C(=O)c2ccccc2)CC1 10.1021/jm0201767
10906911 24761 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 477 8 3 4 5.4 COc1cccc(NC(=O)Nc2ccc(CO)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL126220 24761 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 477 8 3 4 5.4 COc1cccc(NC(=O)Nc2ccc(CO)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
68826395 110283 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 5.0 CC(=O)c1cccc(NC(=O)NCCCN2[C@H]3CC[C@@H]2C[C@H](Cc2ccc(F)cc2)C3)c1 10.1016/j.bmcl.2004.01.059
CHEMBL3085118 110283 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 5.0 CC(=O)c1cccc(NC(=O)NCCCN2[C@H]3CC[C@@H]2C[C@H](Cc2ccc(F)cc2)C3)c1 10.1016/j.bmcl.2004.01.059
10984360 103724 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 537 8 1 7 5.7 CCOC(=O)c1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1 10.1016/s0960-894x(01)00176-7
CHEMBL266181 103724 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 537 8 1 7 5.7 CCOC(=O)c1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1 10.1016/s0960-894x(01)00176-7
44295375 174932 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 419 6 2 4 3.5 CN(C)c1ccc(NC(=O)NCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL433086 174932 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 419 6 2 4 3.5 CN(C)c1ccc(NC(=O)NCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)cc1 10.1016/s0960-894x(02)00206-8
9840971 106515 47 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 342 7 1 5 2.5 CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
CHEMBL284954 106515 47 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 342 7 1 5 2.5 CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
11733139 23676 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 454 7 3 4 5.2 N#Cc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL125132 23676 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 454 7 3 4 5.2 N#Cc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
44289699 174594 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 409 6 2 3 3.9 CC(=O)c1cccc(NC(=O)NCCCN2C[C@@H]3Cc4ccc(F)cc4C[C@H]3C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL43066 174594 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 409 6 2 3 3.9 CC(=O)c1cccc(NC(=O)NCCCN2C[C@@H]3Cc4ccc(F)cc4C[C@H]3C2)c1 10.1016/j.bmcl.2004.01.059
10474776 120434 42 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(03)00748-0
CHEMBL33227 120434 42 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(03)00748-0
44390842 130615 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 7 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL362490 130615 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 7 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
44295485 108649 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 497 12 3 4 5.4 CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccc(F)cc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL300699 108649 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 497 12 3 4 5.4 CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccc(F)cc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
22393287 174743 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL43173 174743 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
11316656 77037 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 441 6 2 2 5.6 O=C(Nc1ccc(F)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL194141 77037 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 441 6 2 2 5.6 O=C(Nc1ccc(F)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
10474776 120434 42 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL33227 120434 42 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
22393287 174743 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL43173 174743 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 451 8 2 6 3.5 Cn1nnnc1-c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.01.059
44593553 185146 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 489 6 2 6 3.9 Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1016/j.bmcl.2008.11.002
CHEMBL465272 185146 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 489 6 2 6 3.9 Cc1csc(NC(=O)NC2(C)CN(C)C(=O)OC2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)n1 10.1016/j.bmcl.2008.11.002
44593546 185536 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 531 6 2 6 4.9 CN1CC(C)(NC(=O)Nc2nc(C(C)(C)C)cs2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
CHEMBL468695 185536 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 531 6 2 6 4.9 CN1CC(C)(NC(=O)Nc2nc(C(C)(C)C)cs2)C(CN2CCC[C@@H](Cc3ccc(F)cc3)C2)OC1=O 10.1016/j.bmcl.2008.11.002
44390911 70581 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 515 8 2 6 4.8 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(Cl)cc3Cl)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL180229 70581 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 515 8 2 6 4.8 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(Cl)cc3Cl)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44390859 138568 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccccc3F)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL369331 138568 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 465 8 2 6 3.7 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccccc3F)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44447369 101386 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 453 9 4 8 1.8 C[C@@H]([C@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL252222 101386 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 453 9 4 8 1.8 C[C@@H]([C@H](O)c1ccccc1)N(C)C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44419308 148308 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 509 10 2 4 5.4 CCC(=O)N1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
CHEMBL384649 148308 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 509 10 2 4 5.4 CCC(=O)N1CC[C@@H](Cc2ccc(F)cc2)C[C@@H]1CCCNC(=O)Nc1cc(C(C)=O)cc(C(C)=O)c1 10.1016/j.bmcl.2006.08.012
44455872 162294 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 467 9 2 4 5.1 CC(=O)c1cc(NC(=O)N[C@@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
CHEMBL404202 162294 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 receptor expressed in CHO cells
ChEMBL 467 9 2 4 5.1 CC(=O)c1cc(NC(=O)N[C@@H](C)CCN2CCC[C@@H](Cc3ccc(F)cc3)C2)cc(C(C)=O)c1 10.1016/j.bmcl.2007.11.067
44295622 108268 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 465 10 3 4 4.7 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@@H](O)C(C)C)c1 10.1016/s0960-894x(02)00206-8
CHEMBL297904 108268 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 465 10 3 4 4.7 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@@H](O)C(C)C)c1 10.1016/s0960-894x(02)00206-8
44295286 195078 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 431 8 2 3 4.0 C[S+]([O-])c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50034 195078 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 431 8 2 3 4.0 C[S+]([O-])c1cccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1016/s0960-894x(02)00206-8
44295672 195535 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 439 6 1 3 5.0 COc1cccc(NC(=O)N2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50535 195535 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 439 6 1 3 5.0 COc1cccc(NC(=O)N2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
44295641 196107 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 453 9 4 5 3.4 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2C(C)(O)O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL51244 196107 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 453 9 4 5 3.4 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2C(C)(O)O)c1 10.1016/s0960-894x(02)00206-8
23509695 196518 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 441 6 1 4 4.0 COc1cccc(NC(=O)N2CCOC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL51584 196518 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 441 6 1 4 4.0 COc1cccc(NC(=O)N2CCOC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
44295364 201731 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 10 3 4 4.5 CC[C@@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL54290 201731 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 10 3 4 4.5 CC[C@@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
22257689 23353 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 446 7 1 2 6.0 Cc1ccc(C(=O)NC(CN2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
CHEMBL123943 23353 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 446 7 1 2 6.0 Cc1ccc(C(=O)NC(CN2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
44346211 170672 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 537 10 2 5 6.5 COc1cc(NC(=O)NC(CC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C(C)C)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
CHEMBL420709 170672 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 537 10 2 5 6.5 COc1cc(NC(=O)NC(CC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)C(C)C)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
44295130 107974 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 362 6 2 3 3.6 N#Cc1cccc(NC(=O)NCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL295726 107974 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 362 6 2 3 3.6 N#Cc1cccc(NC(=O)NCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
44295528 108684 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 336 4 0 2 4.0 Fc1ccc(CCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL300905 108684 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 336 4 0 2 4.0 Fc1ccc(CCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)cc1 10.1016/s0960-894x(02)00206-8
22393370 196634 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 390 7 2 3 4.3 Cc1ccc(CC2CCN(CCCNC(=O)Nc3cccc(C#N)c3)CC2)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL51676 196634 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 390 7 2 3 4.3 Cc1ccc(CC2CCN(CCCNC(=O)Nc3cccc(C#N)c3)CC2)cc1 10.1016/s0960-894x(02)00206-8
22393398 201696 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 390 8 2 3 4.4 N#Cc1cccc(NC(=O)NCCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL54143 201696 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 390 8 2 3 4.4 N#Cc1cccc(NC(=O)NCCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(02)00206-8
10979426 24735 1 None - 0 Human 4.3 pIC50 = 4.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 298 7 3 2 2.7 O=C(NCCCO)NC(Cc1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL126106 24735 1 None - 0 Human 4.3 pIC50 = 4.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 298 7 3 2 2.7 O=C(NCCCO)NC(Cc1ccccc1)c1ccccc1 10.1021/jm0201767
44295102 194730 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 405 7 1 4 3.4 COc1ccc(C(=O)NCCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL49702 194730 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 405 7 1 4 3.4 COc1ccc(C(=O)NCCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)cc1 10.1016/s0960-894x(02)00206-8
10985078 121516 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 635 10 3 3 8.2 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccc(C(F)(F)F)cc1 10.1021/jm0201767
CHEMBL333865 121516 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 635 10 3 3 8.2 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccc(C(F)(F)F)cc1 10.1021/jm0201767
11081509 25315 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 492 6 2 3 6.9 N#Cc1cccc(NC(=O)Nc2c(CN3CCC(Cc4ccc(F)cc4)CC3)ccc3ccccc23)c1 10.1021/jm0201767
CHEMBL127534 25315 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 492 6 2 3 6.9 N#Cc1cccc(NC(=O)Nc2c(CN3CCC(Cc4ccc(F)cc4)CC3)ccc3ccccc23)c1 10.1021/jm0201767
11004826 24760 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 447 7 3 3 5.4 O=C(Nc1ccccc1)Nc1cccc(CO)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL126218 24760 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 447 7 3 3 5.4 O=C(Nc1ccccc1)Nc1cccc(CO)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
44295470 195607 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 425 5 1 3 4.8 COc1cccc(NC(=O)N2CCCC(N3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50645 195607 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 425 5 1 3 4.8 COc1cccc(NC(=O)N2CCCC(N3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1016/s0960-894x(02)00206-8
22022834 120114 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 472 7 1 2 6.4 Cc1ccc(C(=O)NC(CN2CC3CCC2CC3Cc2ccc(Cl)c(Cl)c2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
CHEMBL331672 120114 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 472 7 1 2 6.4 Cc1ccc(C(=O)NC(CN2CC3CCC2CC3Cc2ccc(Cl)c(Cl)c2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
11072275 23569 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 632 10 3 5 5.9 COC(=O)N1CCC(NC(=O)NCC(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)(c2ccccc2)c2ccccc2)CC1 10.1021/jm0201767
CHEMBL124585 23569 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 632 10 3 5 5.9 COC(=O)N1CCC(NC(=O)NCC(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)(c2ccccc2)c2ccccc2)CC1 10.1021/jm0201767
25024651 122814 0 None 39 3 Human 6.3 pIC50 = 6.3 Binding
Inhibition of CCR3 in human eosinophil assessed as inhibition of shape change by autofluorescence assayInhibition of CCR3 in human eosinophil assessed as inhibition of shape change by autofluorescence assay
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
CHEMBL3355956 122814 0 None 39 3 Human 6.3 pIC50 = 6.3 Binding
Inhibition of CCR3 in human eosinophil assessed as inhibition of shape change by autofluorescence assayInhibition of CCR3 in human eosinophil assessed as inhibition of shape change by autofluorescence assay
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
10257335 107221 4 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 565 6 2 4 3.5 CCOC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
CHEMBL290565 107221 4 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 565 6 2 4 3.5 CCOC(=O)[C@H](Cc1cc(I)c(O)c(I)c1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
11227406 101120 2 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Displacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 mins
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
CHEMBL250689 101120 2 None - 0 Mouse 7.3 pIC50 = 7.3 Binding
Displacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from BALB/c mouse CCR3 expressed in CHO cells after 30 mins
ChEMBL 465 7 2 3 5.7 CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2007.03.065
44390858 70677 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 423 6 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NCC2CCN(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL180534 70677 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 423 6 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NCC2CCN(Cc3ccc(F)cc3)CC2)c1 10.1016/j.bmcl.2004.11.006
10928826 24572 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 472 7 3 4 5.3 N#Cc1cccc(NC(=O)Nc2ccc(CO)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL125884 24572 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 472 7 3 4 5.3 N#Cc1cccc(NC(=O)Nc2ccc(CO)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
9951882 185948 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 381 8 2 3 4.2 COc1cccc(NC(=O)NCCCN2CCCC(Cc3ccccc3)C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL47220 185948 0 None - 1 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 381 8 2 3 4.2 COc1cccc(NC(=O)NCCCN2CCCC(Cc3ccccc3)C2)c1 10.1016/j.bmcl.2004.01.059
44295230 195896 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 379 5 1 3 3.2 O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL51038 195896 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 379 5 1 3 3.2 O=C(NCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
44290041 179507 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 409 6 2 3 3.9 CC(=O)c1cccc(NC(=O)NCCCN2C[C@H]3Cc4ccc(F)cc4C[C@H]3C2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL45064 179507 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 409 6 2 3 3.9 CC(=O)c1cccc(NC(=O)NCCCN2C[C@H]3Cc4ccc(F)cc4C[C@H]3C2)c1 10.1016/j.bmcl.2004.01.059
44281790 175992 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 420 6 1 5 4.4 CC(C)(C)OC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL440844 175992 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 420 6 1 5 4.4 CC(C)(C)OC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
11082578 124848 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 603 10 3 3 7.5 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cc(F)ccc1F 10.1021/jm0201767
CHEMBL340491 124848 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 603 10 3 3 7.5 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cc(F)ccc1F 10.1021/jm0201767
44447366 101385 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 453 9 4 8 1.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)[C@H](C)[C@H](O)c1ccccc1 10.1016/j.bmcl.2007.11.087
CHEMBL252221 101385 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 453 9 4 8 1.8 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(C)[C@H](C)[C@H](O)c1ccccc1 10.1016/j.bmcl.2007.11.087
44447141 101362 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 523 11 3 7 3.4 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC(F)(F)F 10.1016/j.bmcl.2007.11.087
CHEMBL252034 101362 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 523 11 3 7 3.4 C[C@@H](NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](O)CN(CCCc1ccc(F)cc1)CC(F)(F)F 10.1016/j.bmcl.2007.11.087
9818195 117141 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 311 7 1 3 3.0 CCOC(=O)[C@H](CCc1ccccc1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
CHEMBL32413 117141 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 311 7 1 3 3.0 CCOC(=O)[C@H](CCc1ccccc1)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
10995329 24953 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 563 13 4 4 5.5 O=C(NCCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL126978 24953 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 563 13 4 4 5.5 O=C(NCCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
44419327 89992 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 393 8 3 3 4.4 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
CHEMBL218581 89992 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 393 8 3 3 4.4 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
44447155 161702 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 511 11 3 7 2.9 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)C(C)=O)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL401002 161702 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 511 11 3 7 2.9 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)C(C)=O)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44445843 101016 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 587 7 2 7 5.5 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)OC(C)(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL250054 101016 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 587 7 2 7 5.5 CC(=O)c1sc(NC(=O)N[C@@H]2CCN(C(=O)OC(C)(C)C)C[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44390978 71346 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 7 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NCC2CCCN(CCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
CHEMBL181575 71346 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 437 7 2 6 3.1 Cn1nnnc1-c1cccc(NC(=O)NCC2CCCN(CCc3ccc(F)cc3)C2)c1 10.1016/j.bmcl.2004.11.006
3492 7479 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 10.1016/s0960-894x(02)00206-8
9868459 7479 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 10.1016/s0960-894x(02)00206-8
CHEMBL50593 7479 0 None - 1 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 10.1016/s0960-894x(02)00206-8
11179592 76367 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 501 6 2 2 6.2 O=C(Nc1ccc(Br)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
CHEMBL193442 76367 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 501 6 2 2 6.2 O=C(Nc1ccc(Br)cc1)N[C@@H]1CCCC[C@H]1CN1CCC[C@@H](Cc2ccc(F)cc2)C1 10.1021/jm049530m
44440431 153240 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 607 9 0 7 5.2 Cc1c(CN(CCc2ccc([N+](=O)[O-])cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL392217 153240 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 607 9 0 7 5.2 Cc1c(CN(CCc2ccc([N+](=O)[O-])cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(F)cc2)n1C 10.1016/j.bmcl.2007.05.035
44445890 161728 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 543 9 2 7 4.1 CC(=O)CN1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
CHEMBL401115 161728 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 543 9 2 7 4.1 CC(=O)CN1CC[C@@H](CN2CCC[C@@H](Cc3ccc(F)cc3)C2)[C@H](NC(=O)Nc2nc(C)c(C(C)=O)s2)C1 10.1016/j.bmcl.2007.03.065
11226588 101540 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 547 10 2 6 5.2 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN(CCCc2ccc(F)cc2)CC(F)(F)F)c1 10.1016/j.bmcl.2007.11.087
CHEMBL253211 101540 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 547 10 2 6 5.2 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN(CCCc2ccc(F)cc2)CC(F)(F)F)c1 10.1016/j.bmcl.2007.11.087
44295201 178121 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 479 11 3 4 5.1 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@H](O)CC(C)C)c1 10.1016/s0960-894x(02)00206-8
CHEMBL446144 178121 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 479 11 3 4 5.1 CC(=O)c1cccc(NC(=O)NCCCN2CC[C@H](Cc3ccccc3)C[C@@H]2[C@H](O)CC(C)C)c1 10.1016/s0960-894x(02)00206-8
44295328 201526 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 437 7 2 2 5.3 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccc(C(F)(F)F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL53673 201526 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 437 7 2 2 5.3 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccc(C(F)(F)F)cc1 10.1016/s0960-894x(02)00206-8
11026367 23254 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 429 7 2 3 5.8 COc1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL123511 23254 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 429 7 2 3 5.8 COc1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
11060510 23274 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 533 10 3 3 6.1 CC(C)NC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL123622 23274 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 533 10 3 3 6.1 CC(C)NC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
11004681 23604 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 439 6 3 3 5.7 O=C(Nc1cccc(CN2CCC(Cc3ccccc3)CC2)c1)Nc1ccc2[nH]ncc2c1 10.1021/jm0201767
CHEMBL124748 23604 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 439 6 3 3 5.7 O=C(Nc1cccc(CN2CCC(Cc3ccccc3)CC2)c1)Nc1ccc2[nH]ncc2c1 10.1021/jm0201767
7072714 117233 3 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 490 11 3 6 3.5 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1016/s0960-894x(01)00248-7
CHEMBL32468 117233 3 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 490 11 3 6 3.5 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 10.1016/s0960-894x(01)00248-7
44440413 100363 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 612 8 0 5 6.4 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(Cl)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL246549 100363 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 612 8 0 5 6.4 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(Cl)cc2)n1C 10.1016/j.bmcl.2007.05.035
10983980 24818 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 505 8 2 5 5.7 COC(=O)c1ccc(NC(=O)Nc2cccc(OC)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL126520 24818 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 505 8 2 5 5.7 COC(=O)c1ccc(NC(=O)Nc2cccc(OC)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
44295463 168783 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 429 7 1 4 3.1 O=S(=O)(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL415950 168783 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 429 7 1 4 3.1 O=S(=O)(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
44419314 90076 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 376 7 3 3 4.1 N#Cc1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
CHEMBL218997 90076 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 376 7 3 3 4.1 N#Cc1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccccc3)CCN2)c1 10.1016/j.bmcl.2006.08.012
44346154 175440 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 489 7 2 4 4.7 C[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 10.1016/s0960-894x(03)00748-0
CHEMBL436363 175440 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 489 7 2 4 4.7 C[C@H](CN1C2CCC1CC(Cc1ccc(Cl)cc1)C2)NC(=O)Nc1cccc(S(C)(=O)=O)c1 10.1016/s0960-894x(03)00748-0
11511522 74642 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 491 8 0 6 3.1 COc1ccc(OC)c(S(=O)(=O)N2CCC(CN3CCN(Cc4ccc(F)cc4)CC3)CC2)c1 10.1016/j.bmcl.2011.09.013
CHEMBL1910163 74642 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 491 8 0 6 3.1 COc1ccc(OC)c(S(=O)(=O)N2CCC(CN3CCN(Cc4ccc(F)cc4)CC3)CC2)c1 10.1016/j.bmcl.2011.09.013
44295407 196420 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 433 6 1 3 4.3 O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)C12CC3CC(CC(C3)C1)C2 10.1016/s0960-894x(02)00206-8
CHEMBL51507 196420 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 433 6 1 3 4.3 O=C(NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)C12CC3CC(CC(C3)C1)C2 10.1016/s0960-894x(02)00206-8
9845853 135253 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 435 7 2 3 5.3 COc1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm049530m
CHEMBL366654 135253 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 435 7 2 3 5.3 COc1cccc(NC(=O)NC2CCCCC2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm049530m
10929194 24746 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 500 7 2 5 5.6 COC(=O)c1ccc(NC(=O)Nc2cccc(C#N)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL126163 24746 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 500 7 2 5 5.6 COC(=O)c1ccc(NC(=O)Nc2cccc(C#N)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
44295065 191070 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 405 7 1 4 3.4 COc1ccccc1C(=O)NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3 10.1016/s0960-894x(02)00206-8
CHEMBL48401 191070 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 405 7 1 4 3.4 COc1ccccc1C(=O)NCCCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3 10.1016/s0960-894x(02)00206-8
10474776 120434 42 None - 0 Human 8.2 pIC50 = 8.2 Binding
Agonistic activity against C-C chemokine receptor type 3 by displacing [125I]-MCP-4 radioligand, using CCR3 binding assayAgonistic activity against C-C chemokine receptor type 3 by displacing [125I]-MCP-4 radioligand, using CCR3 binding assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL33227 120434 42 None - 0 Human 8.2 pIC50 = 8.2 Binding
Agonistic activity against C-C chemokine receptor type 3 by displacing [125I]-MCP-4 radioligand, using CCR3 binding assayAgonistic activity against C-C chemokine receptor type 3 by displacing [125I]-MCP-4 radioligand, using CCR3 binding assay
ChEMBL 378 6 1 5 3.3 COC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
22966050 90911 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 455 10 3 4 4.2 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCO)c1 10.1016/j.bmcl.2006.08.012
CHEMBL220801 90911 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity to CCR3Binding affinity to CCR3
ChEMBL 455 10 3 4 4.2 CC(=O)c1cccc(NC(=O)NCCC[C@H]2C[C@H](Cc3ccc(F)cc3)CCN2CCO)c1 10.1016/j.bmcl.2006.08.012
44295282 108434 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 414 8 2 4 4.2 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccc([N+](=O)[O-])cc1 10.1016/s0960-894x(02)00206-8
CHEMBL299170 108434 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 414 8 2 4 4.2 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccc([N+](=O)[O-])cc1 10.1016/s0960-894x(02)00206-8
44295591 194996 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 465 11 3 4 4.9 CCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL49921 194996 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 465 11 3 4 4.9 CCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
44593555 195563 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of CCR3 at 10 uMInhibition of CCR3 at 10 uM
ChEMBL 642 10 4 6 4.9 CSc1ccc(C(=O)NC2CC(NC(=O)OCc3ccccc3)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2008.12.062
CHEMBL505722 195563 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of CCR3 at 10 uMInhibition of CCR3 at 10 uM
ChEMBL 642 10 4 6 4.9 CSc1ccc(C(=O)NC2CC(NC(=O)OCc3ccccc3)CCC2NC(=O)CNC(=O)c2cccc(C(F)(F)F)c2)cc1 10.1016/j.bmcl.2008.12.062
10874762 23576 1 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 500 7 2 5 5.6 COC(=O)c1cccc(NC(=O)Nc2cccc(C#N)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL124628 23576 1 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 500 7 2 5 5.6 COC(=O)c1cccc(NC(=O)Nc2cccc(C#N)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
44290020 185805 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 435 8 2 4 4.5 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cccc(-n2ccnc2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL47122 185805 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 435 8 2 4 4.5 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cccc(-n2ccnc2)c1 10.1016/j.bmcl.2004.01.059
68826395 110283 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 5.0 CC(=O)c1cccc(NC(=O)NCCCN2[C@H]3CC[C@@H]2C[C@H](Cc2ccc(F)cc2)C3)c1 10.1016/j.bmcl.2004.01.059
CHEMBL3085118 110283 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 5.0 CC(=O)c1cccc(NC(=O)NCCCN2[C@H]3CC[C@@H]2C[C@H](Cc2ccc(F)cc2)C3)c1 10.1016/j.bmcl.2004.01.059
44445850 100857 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 473 7 3 6 3.5 CC(=O)c1sc(NC(=O)N[C@@H]2CNC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL249056 100857 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 473 7 3 6 3.5 CC(=O)c1sc(NC(=O)N[C@@H]2CNC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44390898 71339 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 479 9 2 6 4.2 CCc1cc(NC(=O)N[C@@H]2CCCN(CCCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL181528 71339 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 479 9 2 6 4.2 CCc1cc(NC(=O)N[C@@H]2CCCN(CCCCc3ccc(F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44290029 185926 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 436 8 2 4 4.9 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cccc(-c2cnco2)c1 10.1016/j.bmcl.2004.01.059
CHEMBL47211 185926 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 436 8 2 4 4.9 O=C(NCCCN1CCC[C@@H](Cc2ccc(F)cc2)C1)Nc1cccc(-c2cnco2)c1 10.1016/j.bmcl.2004.01.059
22393474 103325 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 437 7 2 2 5.3 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(C(F)(F)F)c1 10.1016/s0960-894x(02)00206-8
CHEMBL262918 103325 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 437 7 2 2 5.3 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc(C(F)(F)F)c1 10.1016/s0960-894x(02)00206-8
44295288 196127 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 447 8 2 4 3.7 CS(=O)(=O)c1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL51259 196127 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 447 8 2 4 3.7 CS(=O)(=O)c1ccc(NC(=O)NCCCN2CCC(Cc3ccc(F)cc3)CC2)cc1 10.1016/s0960-894x(02)00206-8
44295510 108623 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 401 5 2 4 3.3 N#Cc1cccc(NC(=O)NCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)c1 10.1016/s0960-894x(02)00206-8
CHEMBL300472 108623 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 401 5 2 4 3.3 N#Cc1cccc(NC(=O)NCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)c1 10.1016/s0960-894x(02)00206-8
10591473 71661 10 None - 1 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 279 5 0 1 4.2 c1ccc(CCN2CCC(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
CHEMBL18222 71661 10 None - 1 Human 5.2 pIC50 = 5.2 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 279 5 0 1 4.2 c1ccc(CCN2CCC(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
11812728 23523 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 471 7 2 5 4.8 O=C(NCc1ccc2c(c1)OCO2)Nc1ccccc1CN1CCC(C(=O)c2ccccc2)CC1 10.1021/jm0201767
CHEMBL124336 23523 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 471 7 2 5 4.8 O=C(NCc1ccc2c(c1)OCO2)Nc1ccccc1CN1CCC(C(=O)c2ccccc2)CC1 10.1021/jm0201767
10000888 82752 3 None - 0 Human 6.1 pIC50 = 6.1 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 397 6 1 5 4.2 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccccc2)CC1 10.1016/s0960-894x(01)00176-7
CHEMBL20539 82752 3 None - 0 Human 6.1 pIC50 = 6.1 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 397 6 1 5 4.2 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccccc2)CC1 10.1016/s0960-894x(01)00176-7
10142792 100516 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells
ChEMBL 521 9 5 5 2.8 Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C(=O)NC(C)(C)C)c(C)c1 10.1016/j.bmcl.2007.07.028
CHEMBL247245 100516 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cellsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells
ChEMBL 521 9 5 5 2.8 Cc1ccc(CNC[C@H](NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)C(=O)NC(C)(C)C)c(C)c1 10.1016/j.bmcl.2007.07.028
11069916 23330 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 424 6 2 3 5.7 N#Cc1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL123791 23330 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 424 6 2 3 5.7 N#Cc1cccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
10993686 123715 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 429 7 2 3 5.8 COc1ccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
CHEMBL338543 123715 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 429 7 2 3 5.8 COc1ccc(NC(=O)Nc2ccccc2CN2CCC(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
57394442 74644 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 407 8 2 3 4.2 O=C(NCCCCN1CCC(Oc2ccc(F)cc2)C1)Nc1ccc(F)c(F)c1 10.1016/j.bmcl.2011.09.013
CHEMBL1910165 74644 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 407 8 2 3 4.2 O=C(NCCCCN1CCC(Oc2ccc(F)cc2)C1)Nc1ccc(F)c(F)c1 10.1016/j.bmcl.2011.09.013
11072063 23377 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 597 11 3 4 7.2 COc1ccc(NC(=O)NCC(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)(c2ccccc2)c2ccccc2)cc1 10.1021/jm0201767
CHEMBL124084 23377 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 597 11 3 4 7.2 COc1ccc(NC(=O)NCC(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)(c2ccccc2)c2ccccc2)cc1 10.1021/jm0201767
11026461 23712 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 434 8 2 3 4.7 O=C(NCCN1CCCCC1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL125325 23712 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 434 8 2 3 4.7 O=C(NCCN1CCCCC1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
11005432 175137 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 487 8 2 5 5.6 COC(=O)c1ccc(CN2CCC(Cc3ccccc3)CC2)c(NC(=O)Nc2cccc(OC)c2)c1 10.1021/jm0201767
CHEMBL434437 175137 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 487 8 2 5 5.6 COC(=O)c1ccc(CN2CCC(Cc3ccccc3)CC2)c(NC(=O)Nc2cccc(OC)c2)c1 10.1021/jm0201767
11385474 85311 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)NC2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1021/jm049530m
CHEMBL2112050 85311 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 453 7 2 3 5.5 COc1cccc(NC(=O)NC2CCCC(CN3CCC(Cc4ccc(F)cc4)CC3)C2)c1 10.1021/jm049530m
44346023 21867 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 406 7 1 2 5.7 Cc1ccc(C(=O)NC(CC2CCN(Cc3ccc(C)c(C)c3)CC2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
CHEMBL120957 21867 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 406 7 1 2 5.7 Cc1ccc(C(=O)NC(CC2CCN(Cc3ccc(C)c(C)c3)CC2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
10873705 106112 8 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 431 6 1 5 4.8 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)cc2)CC1 10.1016/s0960-894x(01)00176-7
CHEMBL282285 106112 8 None - 0 Human 7.1 pIC50 = 7.1 Binding
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR3 receptor expressed in CHO cells
ChEMBL 431 6 1 5 4.8 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)cc2)CC1 10.1016/s0960-894x(01)00176-7
44440421 100305 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 593 8 1 6 5.3 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(N)cc2)n1C 10.1016/j.bmcl.2007.05.035
CHEMBL246339 100305 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]eotaxin from CCR3 receptor in human eosinophilsDisplacement of [125I]eotaxin from CCR3 receptor in human eosinophils
ChEMBL 593 8 1 6 5.3 Cc1c(CN(CCc2ccc(Cl)cc2)C2CCN(C(=O)c3c(F)cccc3F)CC2)c(=O)n(-c2ccc(N)cc2)n1C 10.1016/j.bmcl.2007.05.035
3492 7479 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 10.1016/s0960-894x(02)00206-8
9868459 7479 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 10.1016/s0960-894x(02)00206-8
CHEMBL50593 7479 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 10.1016/s0960-894x(02)00206-8
9800669 116276 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 392 7 1 5 3.7 CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL32210 116276 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 392 7 1 5 3.7 CCOC(=O)[C@H](Cc1ccc([N+](=O)[O-])cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
11070954 23551 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 485 7 3 4 4.9 N#Cc1cccc(NC(=O)Nc2ccc(C(N)=O)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL124473 23551 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 485 7 3 4 4.9 N#Cc1cccc(NC(=O)Nc2ccc(C(N)=O)cc2CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
10962347 25269 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 516 8 3 4 5.5 CNC(=O)c1ccc(NC(=O)Nc2cccc(C(C)=O)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
CHEMBL127281 25269 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 516 8 3 4 5.5 CNC(=O)c1ccc(NC(=O)Nc2cccc(C(C)=O)c2)c(CN2CCC(Cc3ccc(F)cc3)CC2)c1 10.1021/jm0201767
11763035 176097 1 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 517 8 2 5 5.9 COC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL441656 176097 1 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 517 8 2 5 5.9 COC(=O)c1cccc(NC(=O)Nc2cccc(C(C)=O)c2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
11753159 7335 6 None 1 2 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at CCR3 assessed as inhibition of eotaxin bindingAntagonist activity at CCR3 assessed as inhibition of eotaxin binding
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1021/jm300682j
7679 7335 6 None 1 2 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at CCR3 assessed as inhibition of eotaxin bindingAntagonist activity at CCR3 assessed as inhibition of eotaxin binding
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1021/jm300682j
CHEMBL2158814 7335 6 None 1 2 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at CCR3 assessed as inhibition of eotaxin bindingAntagonist activity at CCR3 assessed as inhibition of eotaxin binding
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1021/jm300682j
44346210 174734 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 531 10 3 6 4.7 COc1cc(NC(=O)N[C@@H](CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)[C@H](C)O)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
CHEMBL431670 174734 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 531 10 3 6 4.7 COc1cc(NC(=O)N[C@@H](CN2C3CCC2CC(Cc2ccc(Cl)cc2)C3)[C@H](C)O)cc(OC)c1OC 10.1016/s0960-894x(03)00748-0
44295536 195214 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 479 12 3 4 5.3 CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50233 195214 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 479 12 3 4 5.3 CCCC[C@H](O)[C@H]1C[C@@H](Cc2ccccc2)CCN1CCCNC(=O)Nc1cccc(C(C)=O)c1 10.1016/s0960-894x(02)00206-8
9885355 107182 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 363 6 2 4 3.5 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
CHEMBL290119 107182 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 363 6 2 4 3.5 CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1cccc2ccccc12 10.1016/s0960-894x(01)00248-7
44295353 195464 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 350 8 1 2 4.2 O=C(NCCCCN1CCC(Cc2ccccc2)CC1)c1ccccc1 10.1016/s0960-894x(02)00206-8
CHEMBL50401 195464 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 350 8 1 2 4.2 O=C(NCCCCN1CCC(Cc2ccccc2)CC1)c1ccccc1 10.1016/s0960-894x(02)00206-8
71454583 86470 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 4.9 CC(=O)c1cccc(NC(=O)NCCCN2CC3CCC2[C@H](Cc2ccc(F)cc2)C3)c1 10.1016/j.bmcl.2004.01.059
CHEMBL2115412 86470 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.Inhibitory concentration against C-C chemokine receptor type 3 using human [125I]eotaxin.
ChEMBL 437 8 2 3 4.9 CC(=O)c1cccc(NC(=O)NCCCN2CC3CCC2[C@H](Cc2ccc(F)cc2)C3)c1 10.1016/j.bmcl.2004.01.059
11015975 23268 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 459 8 3 4 5.3 COc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
CHEMBL123585 23268 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 459 8 3 4 5.3 COc1cccc(NC(=O)Nc2ccccc2C(O)CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm0201767
44295118 195822 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 405 7 1 4 3.4 COc1cccc(C(=O)NCCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)c1 10.1016/s0960-894x(02)00206-8
CHEMBL50937 195822 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 405 7 1 4 3.4 COc1cccc(C(=O)NCCCCN2CC[C@@H]3[C@H](C2)c2cccc4c2N3CC4)c1 10.1016/s0960-894x(02)00206-8
57398008 74643 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 393 9 2 3 4.5 COc1ccc(Cl)cc1NC(=O)NCCCCN(C)Cc1ccc(F)cc1 10.1016/j.bmcl.2011.09.013
CHEMBL1910164 74643 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assayDisplacement of [125I]-eotaxin from CCR3 expressed in RBL-2H3 cells by scintillation proximity assay
ChEMBL 393 9 2 3 4.5 COc1ccc(Cl)cc1NC(=O)NCCCCN(C)Cc1ccc(F)cc1 10.1016/j.bmcl.2011.09.013
44390893 71148 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 515 8 2 6 4.5 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(C(F)(F)F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL181302 71148 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 515 8 2 6 4.5 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(C(F)(F)F)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
132072454 186503 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at human CCR3 expressed in CHO-K1 cells by PathHunter beta-arrestin assayAntagonist activity at human CCR3 expressed in CHO-K1 cells by PathHunter beta-arrestin assay
ChEMBL 558 6 2 8 4.7 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)[C@H](c3[nH]c4ccccc4c3CCn3cc(-c4cccc(Cl)c4)nn3)C[C@@H]21 10.1016/j.bmc.2020.115546
CHEMBL4744046 186503 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at human CCR3 expressed in CHO-K1 cells by PathHunter beta-arrestin assayAntagonist activity at human CCR3 expressed in CHO-K1 cells by PathHunter beta-arrestin assay
ChEMBL 558 6 2 8 4.7 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)[C@H](c3[nH]c4ccccc4c3CCn3cc(-c4cccc(Cl)c4)nn3)C[C@@H]21 10.1016/j.bmc.2020.115546
44295558 108740 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 365 4 1 3 2.8 O=C(NCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
CHEMBL301332 108740 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 365 4 1 3 2.8 O=C(NCCN1CC[C@@H]2[C@H](C1)c1cccc3c1N2CC3)c1ccc(F)cc1 10.1016/s0960-894x(02)00206-8
10934382 23548 30 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 265 4 0 1 4.1 c1ccc(CC2CCN(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
CHEMBL124457 23548 30 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 265 4 0 1 4.1 c1ccc(CC2CCN(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
11828013 24179 1 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 581 11 3 3 6.9 O=C(NCc1ccccc1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL125753 24179 1 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 581 11 3 3 6.9 O=C(NCc1ccccc1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
11049424 123884 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 505 9 3 3 5.3 CNC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL339349 123884 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 505 9 3 3 5.3 CNC(=O)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
9972570 76606 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 308 7 0 2 3.8 c1ccc(CCCCN2CCN(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
CHEMBL19375 76606 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 308 7 0 2 3.8 c1ccc(CCCCN2CCN(Cc3ccccc3)CC2)cc1 10.1021/jm0201767
10458117 23358 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 486 6 2 5 5.5 N#Cc1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 10.1021/jm0201767
CHEMBL123961 23358 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 486 6 2 5 5.5 N#Cc1cccc(NC(=O)Nc2cc3c(cc2CN2CCC(Cc4ccc(F)cc4)CC2)OCO3)c1 10.1021/jm0201767
44346178 121033 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 423 8 1 4 5.0 Cc1ccc(C(=O)NC(CC2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
CHEMBL333040 121033 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandBinding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligand
ChEMBL 423 8 1 4 5.0 Cc1ccc(C(=O)NC(CC2CCN(Cc3ccc([N+](=O)[O-])cc3)CC2)C(C)C)cc1 10.1016/s0960-894x(03)00748-0
44447377 101606 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 499 11 4 8 2.2 CCN(C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](C)[C@H](O)Cc1ccc(F)cc1 10.1016/j.bmcl.2007.11.087
CHEMBL253666 101606 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 499 11 4 8 2.2 CCN(C[C@H](O)[C@@H](C)NC(=O)Nc1cccc(-c2nnnn2C)c1)[C@@H](C)[C@H](O)Cc1ccc(F)cc1 10.1016/j.bmcl.2007.11.087
44295327 195162 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 414 8 2 4 4.2 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(02)00206-8
CHEMBL50158 195162 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 414 8 2 4 4.2 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1ccccc1[N+](=O)[O-] 10.1016/s0960-894x(02)00206-8
44447150 101720 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 551 12 3 7 3.9 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)CC(F)(F)F)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
CHEMBL254471 101720 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I] eotaxin from human CCR3 receptor in CHO cellsDisplacement of [125I] eotaxin from human CCR3 receptor in CHO cells
ChEMBL 551 12 3 7 3.9 CCc1cc(NC(=O)N[C@H](C)[C@@H](O)CN(CCCc2ccc(F)cc2)CC(F)(F)F)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2007.11.087
44295326 175855 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 414 8 2 4 4.2 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc([N+](=O)[O-])c1 10.1016/s0960-894x(02)00206-8
CHEMBL439744 175855 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 414 8 2 4 4.2 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)Nc1cccc([N+](=O)[O-])c1 10.1016/s0960-894x(02)00206-8
44387850 67288 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 430 6 2 3 5.2 N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm049530m
CHEMBL175679 67288 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 430 6 2 3 5.2 N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC(Cc3ccccc3)CC2)c1 10.1021/jm049530m
11236236 84735 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 448 6 2 3 5.3 N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL2096696 84735 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 448 6 2 3 5.3 N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
11224689 84746 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 448 6 2 3 5.3 N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
CHEMBL2096764 84746 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cellsInhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 448 6 2 3 5.3 N#Cc1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1 10.1021/jm049530m
10939698 168449 1 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 475 7 2 4 5.7 COC(=O)c1cccc(NC(=O)Nc2ccccc2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
CHEMBL413113 168449 1 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 475 7 2 4 5.7 COC(=O)c1cccc(NC(=O)Nc2ccccc2)c1CN1CCC(Cc2ccc(F)cc2)CC1 10.1021/jm0201767
44570582 185196 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 477 10 2 6 3.9 CCCN(CCCc1ccc(F)cc1)C[C@@H]1OC(=O)N(C)C[C@H]1NC(=O)Nc1nc(C)cs1 10.1016/j.bmcl.2008.11.002
CHEMBL465943 185196 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity to CCR3 receptorBinding affinity to CCR3 receptor
ChEMBL 477 10 2 6 3.9 CCCN(CCCc1ccc(F)cc1)C[C@@H]1OC(=O)N(C)C[C@H]1NC(=O)Nc1nc(C)cs1 10.1016/j.bmcl.2008.11.002
44445846 101198 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 587 7 2 7 5.5 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
CHEMBL251078 101198 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 minsDisplacement of [125I]eotaxin from human CCR3 expressed in CHO cells after 30 mins
ChEMBL 587 7 2 7 5.5 CC(=O)c1sc(NC(=O)N[C@@H]2CN(C(=O)OC(C)(C)C)CC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C 10.1016/j.bmcl.2007.03.065
44390882 129579 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 461 8 2 6 3.8 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(C)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
CHEMBL360529 129579 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Evaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cellsEvaluated for inhibition of human C-C chemokine receptor type 3 expressed in CHO cells
ChEMBL 461 8 2 6 3.8 CCc1cc(NC(=O)NC[C@@H]2CCCN(CCc3ccc(C)cc3)C2)cc(-c2nnnn2C)c1 10.1016/j.bmcl.2004.11.006
44295543 108763 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 427 7 2 2 4.7 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NC12CC3CC(CC(C3)C1)C2 10.1016/s0960-894x(02)00206-8
CHEMBL301503 108763 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxinIn vitro inhibition if C-C chemokine receptor type 3 (CCR3) using 150p M [125I]-labeled human eotaxin
ChEMBL 427 7 2 2 4.7 O=C(NCCCN1CCC(Cc2ccc(F)cc2)CC1)NC12CC3CC(CC(C3)C1)C2 10.1016/s0960-894x(02)00206-8
11811443 23389 3 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 399 6 2 2 5.8 O=C(Nc1ccccc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL124134 23389 3 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 399 6 2 2 5.8 O=C(Nc1ccccc1)Nc1ccccc1CN1CCC(Cc2ccccc2)CC1 10.1021/jm0201767
6995527 118676 6 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 221 4 1 3 1.4 CCOC(=O)[C@H](C)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
CHEMBL32878 118676 6 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandInhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligand
ChEMBL 221 4 1 3 1.4 CCOC(=O)[C@H](C)NC(=O)c1ccccc1 10.1016/s0960-894x(01)00248-7
9889700 125366 17 None - 1 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
CHEMBL34166 125366 17 None - 1 Human 5.1 pIC50 = 5.1 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm0201767
11762084 23688 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 446 8 2 3 4.5 O=C(NCCc1ccc(F)cc1)Nc1ccccc1CN1CCN(Cc2ccccc2)CC1 10.1021/jm0201767
CHEMBL125220 23688 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 446 8 2 3 4.5 O=C(NCCc1ccc(F)cc1)Nc1ccccc1CN1CCN(Cc2ccccc2)CC1 10.1021/jm0201767
11060814 23945 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 567 10 3 3 7.2 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccccc1 10.1021/jm0201767
CHEMBL125618 23945 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cellsInhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) expressed in chinese hamster ovary cells
ChEMBL 567 10 3 3 7.2 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccccc1 10.1021/jm0201767
66615627 88053 0 None 158 2 Human 9.7 pKi = 9.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 536 8 1 4 6.1 Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.08.103
CHEMBL2158790 88053 0 None 158 2 Human 9.7 pKi = 9.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 536 8 1 4 6.1 Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.08.103
59296081 90858 0 None 7 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 608 9 3 7 2.9 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)N3CCC3)ccc12 10.1016/j.bmcl.2012.09.112
CHEMBL2207654 90858 0 None 7 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 608 9 3 7 2.9 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)N3CCC3)ccc12 10.1016/j.bmcl.2012.09.112
66615619 88046 0 None 79 2 Human 9.3 pKi = 9.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 522 8 1 4 5.7 Cc1c(Cl)ccc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)c1Cl 10.1016/j.bmcl.2012.08.103
CHEMBL2158783 88046 0 None 79 2 Human 9.3 pKi = 9.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 522 8 1 4 5.7 Cc1c(Cl)ccc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)c1Cl 10.1016/j.bmcl.2012.08.103
12001832 88047 0 None 63 2 Human 9.3 pKi = 9.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 522 8 1 4 5.7 Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.08.103
CHEMBL2158784 88047 0 None 63 2 Human 9.3 pKi = 9.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 522 8 1 4 5.7 Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.08.103
16040671 88054 0 None 56 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 502 8 1 4 5.4 Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158791 88054 0 None 56 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 502 8 1 4 5.4 Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
17963201 89041 0 None 31 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 539 5 1 5 5.0 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(C)c4Cl)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171047 89041 0 None 31 2 Human 9.2 pKi = 9.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 539 5 1 5 5.0 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(C)c4Cl)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
66615702 88050 0 None 100 2 Human 9.1 pKi = 9.1 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 522 8 1 4 5.8 C[C@](Cc1ccc(F)cc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158787 88050 0 None 100 2 Human 9.1 pKi = 9.1 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 522 8 1 4 5.8 C[C@](Cc1ccc(F)cc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
59296033 90793 0 None 15 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 596 9 3 7 2.7 CN(C)S(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
CHEMBL2207286 90793 0 None 15 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 596 9 3 7 2.7 CN(C)S(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
59295968 90861 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 487 7 3 5 3.3 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3c(F)cccc23)CC1 10.1016/j.bmcl.2012.09.112
CHEMBL2207657 90861 0 None 3 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 487 7 3 5 3.3 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3c(F)cccc23)CC1 10.1016/j.bmcl.2012.09.112
59296099 90865 0 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 494 7 3 5 3.7 Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]nc3C(F)(F)F)CC2)c1Cl 10.1016/j.bmcl.2012.09.112
CHEMBL2207660 90865 0 None 50 2 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 494 7 3 5 3.7 Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]nc3C(F)(F)F)CC2)c1Cl 10.1016/j.bmcl.2012.09.112
46931923 136052 0 None - 1 Human 9.1 pKi = 9.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 537 6 1 5 4.2 Cc1cc(C(=O)N2CCCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670798 136052 0 None - 1 Human 9.1 pKi = 9.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 537 6 1 5 4.2 Cc1cc(C(=O)N2CCCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
59295928 90790 0 None 63 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 581 8 3 7 3.2 Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccc(S(C)(=O)=O)cc34)CC2)c1Cl 10.1016/j.bmcl.2012.09.112
CHEMBL2207283 90790 0 None 63 2 Human 9.0 pKi = 9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 581 8 3 7 3.2 Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccc(S(C)(=O)=O)cc34)CC2)c1Cl 10.1016/j.bmcl.2012.09.112
66615606 88048 0 None 398 2 Human 8.9 pKi = 8.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 513 8 1 5 4.9 Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(C#N)c1Cl 10.1016/j.bmcl.2012.08.103
CHEMBL2158785 88048 0 None 398 2 Human 8.9 pKi = 8.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 513 8 1 5 4.9 Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc(C#N)c1Cl 10.1016/j.bmcl.2012.08.103
71462100 88055 0 None 39 2 Human 8.9 pKi = 8.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 502 8 1 4 5.4 Cc1cc(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl 10.1016/j.bmcl.2012.08.103
CHEMBL2158792 88055 0 None 39 2 Human 8.9 pKi = 8.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 502 8 1 4 5.4 Cc1cc(OC2CCN(CC3CCN([C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl 10.1016/j.bmcl.2012.08.103
59295938 90869 0 None 7 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 521 7 3 5 3.6 Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)cc3C(F)(F)F)CC2)c1Cl 10.1016/j.bmcl.2012.09.112
CHEMBL2207664 90869 0 None 7 2 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 521 7 3 5 3.6 Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)cc3C(F)(F)F)CC2)c1Cl 10.1016/j.bmcl.2012.09.112
66615691 88052 0 None 125 2 Human 8.8 pKi = 8.8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 518 8 1 4 5.9 Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.08.103
CHEMBL2158789 88052 0 None 125 2 Human 8.8 pKi = 8.8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 518 8 1 4 5.9 Cc1c(OC2CCN(CC3CCN([C@@](C)(Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.08.103
9870185 90871 0 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 489 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.113
CHEMBL2207666 90871 0 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 489 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.113
59295931 90987 0 None 5 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 462 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c2ccccc12 10.1016/j.bmcl.2012.09.113
CHEMBL2208429 90987 0 None 5 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 462 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c2ccccc12 10.1016/j.bmcl.2012.09.113
59296010 90989 0 None 3 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 490 7 3 6 2.9 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.113
CHEMBL2208431 90989 0 None 3 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 490 7 3 6 2.9 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1n[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.113
71459762 90866 0 None 7 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 452 8 3 5 3.2 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C1CC1 10.1016/j.bmcl.2012.09.112
CHEMBL2207661 90866 0 None 7 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 452 8 3 5 3.2 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C1CC1 10.1016/j.bmcl.2012.09.112
9870185 90871 0 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 489 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.112
CHEMBL2207666 90871 0 None 2 2 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 489 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.112
56967066 136077 0 None - 1 Human 8.8 pKi = 8.8 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 525 7 1 5 4.0 CCN(C)C(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
CHEMBL3670824 136077 0 None - 1 Human 8.8 pKi = 8.8 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 525 7 1 5 4.0 CCN(C)C(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
66615617 88051 0 None 31 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.08.103
CHEMBL2158788 88051 0 None 31 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 Cc1c(OC2CCN(CC3CCN([C@@H](Cc4ccccc4)C(=O)O)CC3)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.08.103
71456722 88056 0 None 39 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 486 8 1 4 4.9 Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158793 88056 0 None 39 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 486 8 1 4 4.9 Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@](C)(Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
69262172 88068 1 None 3 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 462 6 1 4 5.5 O=C(O)c1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158822 88068 1 None 3 2 Human 8.7 pKi = 8.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 462 6 1 4 5.5 O=C(O)c1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
59295935 90785 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 507 7 3 5 3.6 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(F)ccc12 10.1016/j.bmcl.2012.09.112
CHEMBL2207278 90785 0 None 3 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 507 7 3 5 3.6 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(F)ccc12 10.1016/j.bmcl.2012.09.112
59295978 90860 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 507 7 3 5 3.6 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2c(F)cccc12 10.1016/j.bmcl.2012.09.112
CHEMBL2207656 90860 0 None 1 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 507 7 3 5 3.6 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2c(F)cccc12 10.1016/j.bmcl.2012.09.112
59296066 90868 0 None 5 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 487 7 3 5 3.0 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)cc2C(F)(F)F)CC1 10.1016/j.bmcl.2012.09.112
CHEMBL2207663 90868 0 None 5 2 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 487 7 3 5 3.0 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)cc2C(F)(F)F)CC1 10.1016/j.bmcl.2012.09.112
69347575 88067 0 None 10 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)[C@@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158821 88067 0 None 10 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)[C@@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
71072040 88082 0 None 5 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 490 8 1 4 5.2 O=C(O)[C@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158835 88082 0 None 5 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 490 8 1 4 5.2 O=C(O)[C@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
71072044 88084 0 None 5 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 524 8 1 4 5.9 O=C(O)[C@H](Cc1ccccc1Cl)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158837 88084 0 None 5 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 524 8 1 4 5.9 O=C(O)[C@H](Cc1ccccc1Cl)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
71072050 88086 0 None 5 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 508 8 1 4 5.4 O=C(O)[C@H](Cc1ccccc1F)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158839 88086 0 None 5 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 508 8 1 4 5.4 O=C(O)[C@H](Cc1ccccc1F)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
71072118 88088 0 None 5 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 508 8 1 4 5.4 O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158841 88088 0 None 5 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 508 8 1 4 5.4 O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
22397445 89014 0 None 2 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 499 4 1 4 5.0 O=C(c1c[nH]c(=O)c2ccccc12)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171020 89014 0 None 2 2 Human 8.0 pKi = 8 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 499 4 1 4 5.0 O=C(c1c[nH]c(=O)c2ccccc12)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
57718837 122790 0 None -1 3 Mouse 8.0 pKi = 8 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 414 7 1 2 6.4 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355932 122790 0 None -1 3 Mouse 8.0 pKi = 8 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 414 7 1 2 6.4 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
59295946 90788 0 None 5 2 Human 8.0 pKi = 8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 612 11 5 8 1.7 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NCCO)ccc12 10.1016/j.bmcl.2012.09.112
CHEMBL2207281 90788 0 None 5 2 Human 8.0 pKi = 8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 612 11 5 8 1.7 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NCCO)ccc12 10.1016/j.bmcl.2012.09.112
56965995 136050 0 None - 1 Human 8.0 pKi = 8.0 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 497 6 2 5 3.3 CNC(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
CHEMBL3670796 136050 0 None - 1 Human 8.0 pKi = 8.0 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 497 6 2 5 3.3 CNC(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
69260946 88069 1 None -19 2 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 462 6 1 4 5.5 O=C(O)c1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
CHEMBL2158823 88069 1 None -19 2 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 462 6 1 4 5.5 O=C(O)c1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
71462103 88077 1 None -2 2 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 492 8 1 5 5.2 O=C(O)COc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
CHEMBL2158830 88077 1 None -2 2 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 492 8 1 5 5.2 O=C(O)COc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
17963227 89006 0 None -39 2 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 539 5 0 5 5.1 Cc1ccc(S(=O)(=O)N(C)C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171013 89006 0 None -39 2 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 539 5 0 5 5.1 Cc1ccc(S(=O)(=O)N(C)C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
9910169 89011 0 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 422 7 1 4 4.3 COc1cccc(C(=O)NCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.08.124
CHEMBL2171018 89011 0 None - 1 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 422 7 1 4 4.3 COc1cccc(C(=O)NCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.08.124
17963336 89038 0 None -5 2 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 536 5 1 6 4.3 N#Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
CHEMBL2171044 89038 0 None -5 2 Human 7.0 pKi = 7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 536 5 1 6 4.3 N#Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
118721192 122799 0 None 4 2 Rat 7.0 pKi = 7 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 458 8 1 4 6.0 CCOC(=O)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355941 122799 0 None 4 2 Rat 7.0 pKi = 7 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 458 8 1 4 6.0 CCOC(=O)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
10300214 90974 0 None -6 2 Human 7.0 pKi = 7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 492 9 2 5 5.0 O=C(Nc1ccccc1OCC(O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C1CCC1 10.1016/j.bmcl.2012.09.113
CHEMBL2208416 90974 0 None -6 2 Human 7.0 pKi = 7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 492 9 2 5 5.0 O=C(Nc1ccccc1OCC(O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C1CCC1 10.1016/j.bmcl.2012.09.113
44389685 71507 0 None - 1 Human 7.0 pKi = 7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 459 4 1 2 6.3 Cc1ccccc1NC(=O)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL181894 71507 0 None - 1 Human 7.0 pKi = 7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 459 4 1 2 6.3 Cc1ccccc1NC(=O)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
17989653 88237 0 None - 1 Human 7.0 pKi = 7 Binding
Inhibition of CCR3 receptorInhibition of CCR3 receptor
ChEMBL 301 2 1 3 3.2 Fc1ccc2c(c1)nc(CC(F)(F)F)n2C1CCNCC1 10.1016/j.bmc.2012.09.013
CHEMBL2159765 88237 0 None - 1 Human 7.0 pKi = 7 Binding
Inhibition of CCR3 receptorInhibition of CCR3 receptor
ChEMBL 301 2 1 3 3.2 Fc1ccc2c(c1)nc(CC(F)(F)F)n2C1CCNCC1 10.1016/j.bmc.2012.09.013
44389678 130102 0 None - 1 Human 6.0 pKi = 6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 574 6 1 5 4.6 CS(=O)(=O)N[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL361620 130102 0 None - 1 Human 6.0 pKi = 6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 574 6 1 5 4.6 CS(=O)(=O)N[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44389669 69371 0 None - 1 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cccc(Cl)c3Cl)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178286 69371 0 None - 1 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cccc(Cl)c3Cl)CC2)CC1 10.1016/j.bmcl.2005.01.016
44401055 75457 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 454 7 2 4 4.6 COc1ccc(C(CNC(=O)Nc2ccc(F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL192162 75457 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 454 7 2 4 4.6 COc1ccc(C(CNC(=O)Nc2ccc(F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401192 77360 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 529 7 1 3 6.4 CC(C)(C)c1ccc(C(CNC(=O)Cc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL194943 77360 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 529 7 1 3 6.4 CC(C)(C)c1ccc(C(CNC(=O)Cc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401227 142019 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 421 9 1 4 4.5 COc1ccc(C(CNCCc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL372496 142019 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 421 9 1 4 4.5 COc1ccc(C(CNCCc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401173 76636 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 466 8 2 5 4.5 COc1ccc(NC(=O)NCC(c2ccccc2OC)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL193871 76636 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 466 8 2 5 4.5 COc1ccc(NC(=O)NCC(c2ccccc2OC)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44400953 76056 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 488 6 2 3 5.8 Cc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL192751 76056 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 488 6 2 3 5.8 Cc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401108 76601 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 420 5 2 3 4.1 Cc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(C)CC2)cc1 10.1021/jm040827u
CHEMBL193732 76601 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 420 5 2 3 4.1 Cc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(C)CC2)cc1 10.1021/jm040827u
44401062 76825 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 502 9 1 4 5.6 CN(C)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL193975 76825 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 502 9 1 4 5.6 CN(C)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
118721204 122822 0 None 5 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 532 9 3 2 6.7 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)[nH]c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355964 122822 0 None 5 3 Human 8.0 pKi = 8.0 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 532 9 3 2 6.7 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)[nH]c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
11477767 69801 0 None - 1 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL178818 69801 0 None - 1 Human 8.0 pKi = 8.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44391171 138574 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 294 1 0 2 4.7 Clc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
CHEMBL369351 138574 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 294 1 0 2 4.7 Clc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
25024650 122818 0 None -21 3 Mouse 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cccc(C(=O)O)n1 10.1016/j.bmcl.2014.11.063
CHEMBL3355960 122818 0 None -21 3 Mouse 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cccc(C(=O)O)n1 10.1016/j.bmcl.2014.11.063
118721203 122821 0 None -1 3 Mouse 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccnc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355963 122821 0 None -1 3 Mouse 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccnc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)c1 10.1016/j.bmcl.2014.11.063
118721194 122802 0 None -229 3 Rat 6.0 pKi = 6.0 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.4 COC(C)c1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355944 122802 0 None -229 3 Rat 6.0 pKi = 6.0 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.4 COC(C)c1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
25024651 122814 0 None -69 3 Rat 6.0 pKi = 6.0 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
CHEMBL3355956 122814 0 None -69 3 Rat 6.0 pKi = 6.0 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
44389719 69794 0 None - 1 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 408 5 0 2 4.6 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178771 69794 0 None - 1 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 408 5 0 2 4.6 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2005.01.016
44389750 172868 0 None - 1 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 469 4 1 2 6.0 O=C(c1cccc2[nH]ccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL425875 172868 0 None - 1 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 469 4 1 2 6.0 O=C(c1cccc2[nH]ccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
44401247 76200 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 492 6 2 3 5.7 O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(F)cc1 10.1021/jm040827u
CHEMBL193332 76200 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 492 6 2 3 5.7 O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(F)cc1 10.1021/jm040827u
44401111 75182 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 480 6 2 3 5.9 CC(C)(C)c1ccc(C(CNC(=O)Nc2ccc(F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL191719 75182 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 480 6 2 3 5.9 CC(C)(C)c1ccc(C(CNC(=O)Nc2ccc(F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44400945 77898 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 455 7 1 3 5.2 CC(C)(C)c1ccc(C(CNC(=O)Cc2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL195473 77898 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 455 7 1 3 5.2 CC(C)(C)c1ccc(C(CNC(=O)Cc2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
44401128 77889 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 462 6 2 3 5.8 CC(C)(C)c1ccc(C(CNC(=O)Nc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL195427 77889 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 462 6 2 3 5.8 CC(C)(C)c1ccc(C(CNC(=O)Nc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44400972 172772 0 None - 1 Human 4.9 pKi = 4.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 337 7 1 3 3.1 Cc1ccc(CCNCC(c2ccccc2)N2CCN(C)CC2)cc1 10.1021/jm040827u
CHEMBL425377 172772 0 None - 1 Human 4.9 pKi = 4.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 337 7 1 3 3.1 Cc1ccc(CCNCC(c2ccccc2)N2CCN(C)CC2)cc1 10.1021/jm040827u
44401053 77842 0 None - 1 Human 4.9 pKi = 4.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 371 8 1 4 3.0 COc1ccc(C(CNCCc2ccc(F)cc2)N2CCN(C)CC2)cc1 10.1021/jm040827u
CHEMBL195197 77842 0 None - 1 Human 4.9 pKi = 4.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 371 8 1 4 3.0 COc1ccc(C(CNCCc2ccc(F)cc2)N2CCN(C)CC2)cc1 10.1021/jm040827u
44401255 76632 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.5 COc1ccccc1CCNCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
CHEMBL193850 76632 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.5 COc1ccccc1CCNCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
44389674 69407 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 469 4 1 2 6.0 O=C(c1ccc2[nH]ccc2c1)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178367 69407 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 469 4 1 2 6.0 O=C(c1ccc2[nH]ccc2c1)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
71451391 88044 0 None 12 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 472 8 1 4 4.5 Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158781 88044 0 None 12 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 472 8 1 4 4.5 Cc1cc(F)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
10005242 88065 0 None 3 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)C(c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158819 88065 0 None 3 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)C(c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
23102749 89009 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 6 1 5 4.3 Cc1c(Cl)ccc(OC2CCN(C3CCN(S(=O)(=O)NC(=O)c4ccccc4)CC3)CC2)c1Cl 10.1016/j.bmcl.2012.08.124
CHEMBL2171016 89009 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 6 1 5 4.3 Cc1c(Cl)ccc(OC2CCN(C3CCN(S(=O)(=O)NC(=O)c4ccccc4)CC3)CC2)c1Cl 10.1016/j.bmcl.2012.08.124
59295926 90993 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 474 7 2 6 3.6 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cnnc2ccccc12 10.1016/j.bmcl.2012.09.113
CHEMBL2208435 90993 0 None -1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 474 7 2 6 3.6 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cnnc2ccccc12 10.1016/j.bmcl.2012.09.113
59295914 90859 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 638 9 4 8 2.2 CC1(O)CN(S(=O)(=O)c2ccc3c(C(=O)NC[C@@H](O)CN4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)c[nH]c(=O)c3c2)C1 10.1016/j.bmcl.2012.09.112
CHEMBL2207655 90859 0 None 1 2 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 638 9 4 8 2.2 CC1(O)CN(S(=O)(=O)c2ccc3c(C(=O)NC[C@@H](O)CN4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)c[nH]c(=O)c3c2)C1 10.1016/j.bmcl.2012.09.112
11952525 122816 0 None 21 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 562 10 0 5 8.0 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355958 122816 0 None 21 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 562 10 0 5 8.0 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)cc1 10.1016/j.bmcl.2014.11.063
11952526 122811 0 None -24 3 Mouse 6.9 pKi = 6.9 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 534 9 1 4 7.5 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355953 122811 0 None -24 3 Mouse 6.9 pKi = 6.9 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 534 9 1 4 7.5 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
44391160 130066 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 413 1 1 4 5.6 CC(C)(C)c1csc2nc3n(c(=N)c12)CC/C3=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL361430 130066 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 413 1 1 4 5.6 CC(C)(C)c1csc2nc3n(c(=N)c12)CC/C3=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
44401004 77345 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 471 8 1 3 5.5 Fc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL194885 77345 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 471 8 1 3 5.5 Fc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
44389699 70692 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 445 4 1 3 5.1 Nc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2005.01.016
CHEMBL180599 70692 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 445 4 1 3 5.1 Nc1cccc(C(=O)N2CCC(N3CCC(Cc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2005.01.016
71462102 88063 0 None -6 2 Human 6.9 pKi = 6.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 478 7 1 5 4.4 O=C(O)C(c1ccccc1)N1CCO[C@@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2012.08.103
CHEMBL2158817 88063 0 None -6 2 Human 6.9 pKi = 6.9 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 478 7 1 5 4.4 O=C(O)C(c1ccccc1)N1CCO[C@@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2012.08.103
71455217 89036 0 None -3 2 Human 6.9 pKi = 6.9 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
CHEMBL2171042 89036 0 None -3 2 Human 6.9 pKi = 6.9 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1cccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
17963141 89043 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 491 5 1 5 4.1 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171049 89043 0 None -1 2 Human 6.9 pKi = 6.9 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 491 5 1 5 4.1 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
71459825 90975 0 None 3 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 433 8 2 5 3.9 N#Cc1ccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/j.bmcl.2012.09.113
CHEMBL2208417 90975 0 None 3 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 433 8 2 5 3.9 N#Cc1ccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/j.bmcl.2012.09.113
71463288 90979 0 None -6 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 441 8 1 5 5.0 COc1cccc(SC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
CHEMBL2208421 90979 0 None -6 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 441 8 1 5 5.0 COc1cccc(SC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
44400992 76732 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 474 6 2 3 5.8 O=C(NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1)Nc1cc(Cl)cc(Cl)c1 10.1021/jm040827u
CHEMBL193931 76732 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 474 6 2 3 5.8 O=C(NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1)Nc1cc(Cl)cc(Cl)c1 10.1021/jm040827u
44389747 175982 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 424 5 0 2 5.1 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cccc(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL440750 175982 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 424 5 0 2 5.1 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cccc(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
44401135 76428 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 527 8 1 3 6.8 FC(F)(F)c1ccc(C(CNCCc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL193507 76428 0 None - 1 Human 6.9 pKi = 6.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 527 8 1 3 6.8 FC(F)(F)c1ccc(C(CNCCc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
118721187 122794 0 None -1 3 Mouse 6.9 pKi = 6.9 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(OC)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355936 122794 0 None -1 3 Mouse 6.9 pKi = 6.9 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(OC)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721188 122795 0 None -2 3 Mouse 5.9 pKi = 5.9 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C(N)=O)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355937 122795 0 None -2 3 Mouse 5.9 pKi = 5.9 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C(N)=O)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721200 122812 0 None -275 3 Rat 5.9 pKi = 5.9 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 558 9 1 6 7.0 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(-c2nnn[nH]2)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355954 122812 0 None -275 3 Rat 5.9 pKi = 5.9 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 558 9 1 6 7.0 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(-c2nnn[nH]2)cc1 10.1016/j.bmcl.2014.11.063
44401202 76904 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 542 6 2 3 6.5 O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(C(F)(F)F)cc1 10.1021/jm040827u
CHEMBL194025 76904 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 542 6 2 3 6.5 O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(C(F)(F)F)cc1 10.1021/jm040827u
44401183 76928 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 459 8 1 3 5.5 FC(F)(F)c1ccc(CCNCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL194040 76928 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 459 8 1 3 5.5 FC(F)(F)c1ccc(CCNCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44389709 70479 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 445 4 1 3 5.1 Nc1ccc(C(=O)N2CCC(N3CCC(Cc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2005.01.016
CHEMBL180122 70479 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 445 4 1 3 5.1 Nc1ccc(C(=O)N2CCC(N3CCC(Cc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2005.01.016
44389688 71319 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 495 4 0 3 6.3 C[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL181460 71319 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 495 4 0 3 6.3 C[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44391330 70795 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 322 2 0 2 5.5 CCC1C/C(=C\c2ccccc2Cl)C2=Nc3ccccc3CN21 10.1016/j.bmcl.2004.11.039
CHEMBL180721 70795 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 322 2 0 2 5.5 CCC1C/C(=C\c2ccccc2Cl)C2=Nc3ccccc3CN21 10.1016/j.bmcl.2004.11.039
44389721 71057 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1nccc2ccccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL180988 71057 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1nccc2ccccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
44391276 129731 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 278 1 0 2 4.2 Fc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
CHEMBL360738 129731 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 278 1 0 2 4.2 Fc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
44391297 139266 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 288 2 0 2 4.6 CCc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
CHEMBL369778 139266 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 288 2 0 2 4.6 CCc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
44391307 175091 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 337 2 0 3 4.7 CN(C)c1ccc(/C=C2\CCN3Cc4ccccc4N=C23)c(Cl)c1 10.1016/j.bmcl.2004.11.039
CHEMBL434151 175091 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 337 2 0 3 4.7 CN(C)c1ccc(/C=C2\CCN3Cc4ccccc4N=C23)c(Cl)c1 10.1016/j.bmcl.2004.11.039
118721191 122798 0 None -331 3 Rat 5.9 pKi = 5.9 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 444 8 1 3 6.5 COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355940 122798 0 None -331 3 Rat 5.9 pKi = 5.9 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 444 8 1 3 6.5 COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
70790201 136056 0 None - 1 Human 5.9 pKi = 5.9 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 440 5 0 4 3.7 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)N(C)c3ccccn3)CC2)ccc1Cl nan
CHEMBL3670803 136056 0 None - 1 Human 5.9 pKi = 5.9 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 440 5 0 4 3.7 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)N(C)c3ccccn3)CC2)ccc1Cl nan
44389695 70704 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 424 5 0 2 5.1 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL180651 70704 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 424 5 0 2 5.1 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2005.01.016
44389712 69870 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 442 5 0 2 5.3 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)cc3F)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178916 69870 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 442 5 0 2 5.3 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)cc3F)CC2)CC1 10.1016/j.bmcl.2005.01.016
44401086 77306 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 474 6 2 3 5.5 O=C(NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(C(F)(F)F)cc1 10.1021/jm040827u
CHEMBL194715 77306 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 474 6 2 3 5.5 O=C(NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(C(F)(F)F)cc1 10.1021/jm040827u
44401251 76201 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 498 7 2 4 5.4 COc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL193334 76201 0 None - 1 Human 4.8 pKi = 4.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 498 7 2 4 5.4 COc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
11283679 71136 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4cccnc4n3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL181273 71136 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4cccnc4n3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
17963315 89027 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 511 5 1 5 4.4 O=C(NS(=O)(=O)c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171033 89027 0 None 1 2 Human 7.8 pKi = 7.8 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 511 5 1 5 4.4 O=C(NS(=O)(=O)c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
59296109 90986 0 None 12 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 500 8 2 6 3.0 CS(=O)(=O)c1ccccc1C(=O)NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2012.09.113
CHEMBL2208428 90986 0 None 12 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 500 8 2 6 3.0 CS(=O)(=O)c1ccccc1C(=O)NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2012.09.113
59296077 90783 0 None 5 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 547 8 3 7 2.5 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(S(C)(=O)=O)ccc23)CC1 10.1016/j.bmcl.2012.09.112
CHEMBL2207276 90783 0 None 5 2 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 547 8 3 7 2.5 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(S(C)(=O)=O)ccc23)CC1 10.1016/j.bmcl.2012.09.112
44400973 134301 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.5 COc1ccc(C(CNC(=O)Nc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL366231 134301 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.5 COc1ccc(C(CNC(=O)Nc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
69260851 88070 1 None -2 2 Human 6.8 pKi = 6.8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 462 6 1 4 5.5 O=C(O)c1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
CHEMBL2158824 88070 1 None -2 2 Human 6.8 pKi = 6.8 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 462 6 1 4 5.5 O=C(O)c1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
10143016 89048 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 6 1 5 4.5 O=C(NS(=O)(=O)Cc1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171215 89048 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 6 1 5 4.5 O=C(NS(=O)(=O)Cc1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
71454365 90976 0 None 1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 465 8 2 6 4.6 O[C@@H](CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)COc1ccc2ncsc2c1 10.1016/j.bmcl.2012.09.113
CHEMBL2208418 90976 0 None 1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 465 8 2 6 4.6 O[C@@H](CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1)COc1ccc2ncsc2c1 10.1016/j.bmcl.2012.09.113
59296073 90980 0 None -1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 483 8 2 6 3.0 N#Cc1cccc(S(=O)(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
CHEMBL2208422 90980 0 None -1 2 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 483 8 2 6 3.0 N#Cc1cccc(S(=O)(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
44401172 130969 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 445 10 1 5 4.4 COc1ccccc1CCNCC(c1ccccc1OC)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
CHEMBL363409 130969 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 445 10 1 5 4.4 COc1ccccc1CCNCC(c1ccccc1OC)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
25024651 122814 0 None 39 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
CHEMBL3355956 122814 0 None 39 3 Human 7.8 pKi = 7.8 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
44391296 72077 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 328 1 0 2 5.0 FC(F)(F)c1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
CHEMBL182889 72077 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 328 1 0 2 5.0 FC(F)(F)c1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
44389722 71058 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 538 5 1 4 5.2 CC(=O)N[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL180989 71058 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 538 5 1 4 5.2 CC(=O)N[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44401052 76854 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 496 9 1 4 5.5 CN(C)c1ccc(C(CNCCc2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL193991 76854 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 496 9 1 4 5.5 CN(C)c1ccc(C(CNCCc2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
56967062 136069 0 None - 1 Human 7.8 pKi = 7.8 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 531 6 1 5 4.0 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)n1 nan
CHEMBL3670816 136069 0 None - 1 Human 7.8 pKi = 7.8 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 531 6 1 5 4.0 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)n1 nan
44391318 72476 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 328 1 0 2 5.3 Clc1ccc(/C=C2\CCN3Cc4ccccc4N=C23)c(Cl)c1 10.1016/j.bmcl.2004.11.039
CHEMBL183441 72476 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 328 1 0 2 5.3 Clc1ccc(/C=C2\CCN3Cc4ccccc4N=C23)c(Cl)c1 10.1016/j.bmcl.2004.11.039
118721199 122807 0 None 2 2 Rat 5.8 pKi = 5.8 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 440 8 2 3 5.9 CCc1[nH]c2cc(C(=O)O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355949 122807 0 None 2 2 Rat 5.8 pKi = 5.8 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 440 8 2 3 5.9 CCc1[nH]c2cc(C(=O)O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
25024650 122818 0 None -338 3 Rat 5.8 pKi = 5.8 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cccc(C(=O)O)n1 10.1016/j.bmcl.2014.11.063
CHEMBL3355960 122818 0 None -338 3 Rat 5.8 pKi = 5.8 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cccc(C(=O)O)n1 10.1016/j.bmcl.2014.11.063
44401235 76617 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.5 COc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL193810 76617 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.5 COc1ccc(NC(=O)NCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44400995 77874 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 505 7 2 4 5.9 CN(C)c1ccc(NC(=O)NCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL195353 77874 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 505 7 2 4 5.9 CN(C)c1ccc(NC(=O)NCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401188 76592 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 428 9 1 4 4.4 CN(C)c1ccc(CCNCC(c2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL193656 76592 0 None - 1 Human 5.8 pKi = 5.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 428 9 1 4 4.4 CN(C)c1ccc(CCNCC(c2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
44401047 77905 0 None - 1 Human 6.8 pKi = 6.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 462 7 2 3 5.7 Cc1ccc(NC(=O)NCC(CC(C)C)N2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1021/jm040827u
CHEMBL195495 77905 0 None - 1 Human 6.8 pKi = 6.8 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 462 7 2 3 5.7 Cc1ccc(NC(=O)NCC(CC(C)C)N2CCN(c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1021/jm040827u
118721190 122797 0 None 5 3 Mouse 7.8 pKi = 7.8 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 416 7 2 3 5.3 OCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355939 122797 0 None 5 3 Mouse 7.8 pKi = 7.8 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 416 7 2 3 5.3 OCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
11214422 130439 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3cccc4cccnc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL362040 130439 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3cccc4cccnc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44391258 129172 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 328 1 0 2 5.3 Clc1cccc(Cl)c1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
CHEMBL360075 129172 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 328 1 0 2 5.3 Clc1cccc(Cl)c1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
67114884 136055 0 None - 1 Human 7.7 pKi = 7.7 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 6 1 6 3.1 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N4CCOCC4)ccn3)CC2)ccc1Cl nan
CHEMBL3670802 136055 0 None - 1 Human 7.7 pKi = 7.7 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 6 1 6 3.1 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N4CCOCC4)ccn3)CC2)ccc1Cl nan
71072115 88033 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 515 8 1 5 5.1 N#Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
CHEMBL2158770 88033 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 515 8 1 5 5.1 N#Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
71072081 88036 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
CHEMBL2158773 88036 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 Cc1cccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
71072113 88037 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
CHEMBL2158774 88037 0 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
11444350 88040 0 None 7 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 558 8 1 4 6.3 O=C(O)[C@H](Cc1cccc(C(F)(F)F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158777 88040 0 None 7 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 558 8 1 4 6.3 O=C(O)[C@H](Cc1cccc(C(F)(F)F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
71449584 88071 1 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)Cc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158825 88071 1 None -1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)Cc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
69347719 88078 1 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)c1ccccc1CN1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158831 88078 1 None 3 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)c1ccccc1CN1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
71460419 88085 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 524 8 1 4 5.9 O=C(O)[C@H](Cc1ccc(Cl)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158838 88085 0 None 1 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 524 8 1 4 5.9 O=C(O)[C@H](Cc1ccc(Cl)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
17963334 89032 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171038 89032 0 None 2 2 Human 7.7 pKi = 7.7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
59296064 90981 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 447 7 2 5 3.5 N#Cc1cccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
CHEMBL2208423 90981 0 None -1 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 447 7 2 5 3.5 N#Cc1cccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
59295960 90872 0 None 12 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 532 8 4 6 2.6 NC(=O)c1c(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.09.112
CHEMBL2207667 90872 0 None 12 2 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 532 8 4 6 2.6 NC(=O)c1c(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)ccc(Cl)c1Cl 10.1016/j.bmcl.2012.09.112
118721197 122805 0 None 19 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(OC)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355947 122805 0 None 19 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(OC)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44389730 71372 0 None - 1 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 442 5 0 2 5.3 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)c(F)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL181678 71372 0 None - 1 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 442 5 0 2 5.3 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)c(F)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
70790198 136049 0 None - 1 Human 6.7 pKi = 6.7 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 454 6 1 4 4.2 CCc1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
CHEMBL3670795 136049 0 None - 1 Human 6.7 pKi = 6.7 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 454 6 1 4 4.2 CCc1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
44401056 76623 0 None - 1 Human 5.7 pKi = 5.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 492 7 2 4 5.8 COc1ccc(NC(=O)NCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL193827 76623 0 None - 1 Human 5.7 pKi = 5.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 492 7 2 4 5.8 COc1ccc(NC(=O)NCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
71462389 89018 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 5 1 4 4.8 O=C(O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
CHEMBL2171024 89018 0 None -1 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 5 1 4 4.8 O=C(O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
71462390 89020 0 None -6 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 500 5 1 6 4.3 O=C(c1ccc(-c2nn[nH]n2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171026 89020 0 None -6 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 500 5 1 6 4.3 O=C(c1ccc(-c2nn[nH]n2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
59296114 90983 0 None -12 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 480 7 2 6 3.4 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cn2cc(F)ccc2n1 10.1016/j.bmcl.2012.09.113
CHEMBL2208425 90983 0 None -12 2 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 480 7 2 6 3.4 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cn2cc(F)ccc2n1 10.1016/j.bmcl.2012.09.113
67114949 136063 0 None - 1 Human 8.6 pKi = 8.6 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 7 1 5 4.4 Cc1cc(C(=O)N(C)C(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670810 136063 0 None - 1 Human 8.6 pKi = 8.6 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 7 1 5 4.4 Cc1cc(C(=O)N(C)C(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
56967064 136073 0 None - 1 Human 8.6 pKi = 8.6 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 537 7 1 5 4.2 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)cc(C4CC4)n3)CC2)ccc1Cl nan
CHEMBL3670820 136073 0 None - 1 Human 8.6 pKi = 8.6 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 537 7 1 5 4.2 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)cc(C4CC4)n3)CC2)ccc1Cl nan
59295939 90988 0 None 12 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 461 7 3 4 4.1 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c2ccccc12 10.1016/j.bmcl.2012.09.113
CHEMBL2208430 90988 0 None 12 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 461 7 3 4 4.1 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c2ccccc12 10.1016/j.bmcl.2012.09.113
59296000 90990 0 None 7 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 478 6 3 6 3.1 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)n1c(=O)[nH]c2ccccc21 10.1016/j.bmcl.2012.09.113
CHEMBL2208432 90990 0 None 7 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 478 6 3 6 3.1 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)n1c(=O)[nH]c2ccccc21 10.1016/j.bmcl.2012.09.113
59296104 90991 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 503 7 2 5 3.8 CN(C[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C(=O)c1c[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.113
CHEMBL2208433 90991 0 None 1 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 503 7 2 5 3.8 CN(C[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)C(=O)c1c[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.113
59295974 90877 0 None 19 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 581 8 3 7 3.2 Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4cc(S(C)(=O)=O)ccc34)CC2)c1Cl 10.1016/j.bmcl.2012.09.112
CHEMBL2207672 90877 0 None 19 2 Human 8.6 pKi = 8.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 581 8 3 7 3.2 Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4cc(S(C)(=O)=O)ccc34)CC2)c1Cl 10.1016/j.bmcl.2012.09.112
11179794 71067 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3nccc4ccccc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL181034 71067 0 None - 1 Human 7.7 pKi = 7.7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3nccc4ccccc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44389770 130599 0 None - 1 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 552 6 1 4 5.5 CC(=O)NC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL362401 130599 0 None - 1 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 552 6 1 4 5.5 CC(=O)NC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44400954 133833 0 None - 1 Human 5.7 pKi = 5.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 518 6 2 3 7.1 CC(C)(C)c1ccc(NC(=O)NCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL365584 133833 0 None - 1 Human 5.7 pKi = 5.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 518 6 2 3 7.1 CC(C)(C)c1ccc(NC(=O)NCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
118721186 122793 0 None -2 3 Mouse 6.7 pKi = 6.7 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(O)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355935 122793 0 None -2 3 Mouse 6.7 pKi = 6.7 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(O)cc2)CC1 10.1016/j.bmcl.2014.11.063
44400982 77900 0 None - 1 Human 6.7 pKi = 6.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 477 9 1 4 5.8 COc1ccccc1CCNCC(c1ccc(C(C)(C)C)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
CHEMBL195480 77900 0 None - 1 Human 6.7 pKi = 6.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 477 9 1 4 5.8 COc1ccccc1CCNCC(c1ccc(C(C)(C)C)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
44401252 77591 0 None - 1 Human 4.7 pKi = 4.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 323 7 1 3 2.8 CN1CCN(C(CNCCc2ccccc2)c2ccccc2)CC1 10.1021/jm040827u
CHEMBL195093 77591 0 None - 1 Human 4.7 pKi = 4.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 323 7 1 3 2.8 CN1CCN(C(CNCCc2ccccc2)c2ccccc2)CC1 10.1021/jm040827u
44401225 76735 0 None - 1 Human 6.7 pKi = 6.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 515 8 1 3 7.1 CC(C)(C)c1ccc(C(CNCCc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL193938 76735 0 None - 1 Human 6.7 pKi = 6.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 515 8 1 3 7.1 CC(C)(C)c1ccc(C(CNCCc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401067 175204 0 None - 1 Human 5.7 pKi = 5.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 450 7 2 4 4.8 COc1ccc(C(CNC(=O)Nc2ccc(C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL434918 175204 0 None - 1 Human 5.7 pKi = 5.7 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 450 7 2 4 4.8 COc1ccc(C(CNC(=O)Nc2ccc(C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44389690 71441 0 None - 1 Human 5.7 pKi = 5.7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 426 5 0 2 4.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(F)cc(F)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL181827 71441 0 None - 1 Human 5.7 pKi = 5.7 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 426 5 0 2 4.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(F)cc(F)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
11386642 69864 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 507 5 0 3 6.5 C=C[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL178887 69864 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 507 5 0 3 6.5 C=C[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
56966925 136045 0 None - 1 Human 7.6 pKi = 7.6 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 483 6 2 5 3.0 CNC(=O)c1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
CHEMBL3670791 136045 0 None - 1 Human 7.6 pKi = 7.6 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 483 6 2 5 3.0 CNC(=O)c1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
24937092 122815 0 None -2 2 Mouse 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 500 10 0 5 6.4 CCOC(=O)Cn1c(CC)c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc21 10.1016/j.bmcl.2014.11.063
CHEMBL3355957 122815 0 None -2 2 Mouse 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 500 10 0 5 6.4 CCOC(=O)Cn1c(CC)c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc21 10.1016/j.bmcl.2014.11.063
118721186 122793 0 None -29 3 Rat 5.6 pKi = 5.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(O)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355935 122793 0 None -29 3 Rat 5.6 pKi = 5.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(O)cc2)CC1 10.1016/j.bmcl.2014.11.063
44401109 77856 0 None - 1 Human 6.6 pKi = 6.6 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 515 8 1 3 6.8 CC(C)(C)c1ccc(C(CNCCc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL195293 77856 0 None - 1 Human 6.6 pKi = 6.6 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 515 8 1 3 6.8 CC(C)(C)c1ccc(C(CNCCc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
56966998 136067 0 None - 1 Human 6.6 pKi = 6.6 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 527 7 1 6 3.3 COc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670814 136067 0 None - 1 Human 6.6 pKi = 6.6 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 527 7 1 6 3.3 COc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
118721194 122802 0 None -5 3 Mouse 7.6 pKi = 7.6 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.4 COC(C)c1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355944 122802 0 None -5 3 Mouse 7.6 pKi = 7.6 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.4 COC(C)c1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
71460416 88039 0 None 2 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 520 9 1 5 5.3 COc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
CHEMBL2158776 88039 0 None 2 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 520 9 1 5 5.3 COc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
71456725 88073 1 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)Cc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
CHEMBL2158827 88073 1 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)Cc1ccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
71072057 88087 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 508 8 1 4 5.4 O=C(O)[C@H](Cc1cccc(F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158840 88087 0 None 5 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 508 8 1 4 5.4 O=C(O)[C@H](Cc1cccc(F)c1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
17963332 89034 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 541 6 1 6 4.4 COc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171040 89034 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 541 6 1 6 4.4 COc1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
17963153 89040 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4Cl)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171046 89040 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4Cl)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
59295982 90789 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 568 8 4 7 2.1 NS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
CHEMBL2207282 90789 0 None -1 2 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 568 8 4 7 2.1 NS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
44391331 71608 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 394 4 0 2 6.3 CCCCC1C/C(=C\c2ccccc2Br)C2=Nc3ccccc3CN21 10.1016/j.bmcl.2004.11.039
CHEMBL181984 71608 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 394 4 0 2 6.3 CCCCC1C/C(=C\c2ccccc2Br)C2=Nc3ccccc3CN21 10.1016/j.bmcl.2004.11.039
44389698 71144 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(Cl)ccc3Cl)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL181290 71144 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(Cl)ccc3Cl)CC2)CC1 10.1016/j.bmcl.2005.01.016
69347980 88079 1 None -5 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)c1cccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
CHEMBL2158832 88079 1 None -5 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)c1cccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
71458869 89016 0 None -2 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 506 7 1 5 4.6 O=C(O)COc1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
CHEMBL2171022 89016 0 None -2 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 506 7 1 5 4.6 O=C(O)COc1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
71449857 89017 0 None -10 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 5 1 4 4.8 O=C(O)c1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171023 89017 0 None -10 2 Human 6.6 pKi = 6.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 5 1 4 4.8 O=C(O)c1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
71463287 90977 0 None -79 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 420 7 1 5 4.1 N#Cc1cccc(OC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
CHEMBL2208419 90977 0 None -79 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 420 7 1 5 4.1 N#Cc1cccc(OC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
59296085 90984 0 None -2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 506 8 2 7 3.1 CS(=O)(=O)c1ccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)s1 10.1016/j.bmcl.2012.09.113
CHEMBL2208426 90984 0 None -2 2 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 506 8 2 7 3.1 CS(=O)(=O)c1ccc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)s1 10.1016/j.bmcl.2012.09.113
71458870 89025 0 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 5 1 4 5.2 Cc1ccc(C(=O)N2CCC(N3CC[C@@H](Oc4ccc(Cl)c(C)c4Cl)C[C@H]3C(=O)O)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171031 89025 0 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 5 1 4 5.2 Cc1ccc(C(=O)N2CCC(N3CC[C@@H](Oc4ccc(Cl)c(C)c4Cl)C[C@H]3C(=O)O)CC2)cc1 10.1016/j.bmcl.2012.08.124
44389832 70698 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3ccnc4ccccc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL180621 70698 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3ccnc4ccccc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44391176 129389 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 385 1 1 4 4.9 Cc1sc2nc3n(c(=N)c2c1C)CC/C3=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL360268 129389 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 385 1 1 4 4.9 Cc1sc2nc3n(c(=N)c2c1C)CC/C3=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
57718837 122790 0 None -45 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 414 7 1 2 6.4 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355932 122790 0 None -45 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 414 7 1 2 6.4 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721189 122796 0 None -7 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 400 6 1 2 6.1 Cc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355938 122796 0 None -7 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 400 6 1 2 6.1 Cc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
11952524 122809 0 None -3 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 490 8 0 3 7.8 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccccc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355951 122809 0 None -3 3 Rat 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 490 8 0 3 7.8 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccccc1 10.1016/j.bmcl.2014.11.063
11952525 122816 0 None -21 3 Mouse 5.6 pKi = 5.6 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 562 10 0 5 8.0 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355958 122816 0 None -21 3 Mouse 5.6 pKi = 5.6 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 562 10 0 5 8.0 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)cc1 10.1016/j.bmcl.2014.11.063
118721201 122813 0 None 2 2 Rat 5.6 pKi = 5.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 548 10 1 4 7.6 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1Cc1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355955 122813 0 None 2 2 Rat 5.6 pKi = 5.6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 548 10 1 4 7.6 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1Cc1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
44389688 71319 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 495 4 0 3 6.3 C[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL181460 71319 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 495 4 0 3 6.3 C[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44401117 76980 0 None - 1 Human 4.6 pKi = 4.6 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 413 7 1 3 4.2 Cc1ccc(CC(=O)NCC(c2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL194070 76980 0 None - 1 Human 4.6 pKi = 4.6 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 413 7 1 3 4.2 Cc1ccc(CC(=O)NCC(c2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
44391277 72560 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 369 1 1 4 4.4 Cc1oc2nc3n(c(=N)c2c1C)CC/C3=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL183478 72560 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 369 1 1 4 4.4 Cc1oc2nc3n(c(=N)c2c1C)CC/C3=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
118721205 122823 0 None -67 3 Mouse 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 653 11 3 5 7.2 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)O)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355965 122823 0 None -67 3 Mouse 6.6 pKi = 6.6 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 653 11 3 5 7.2 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)O)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
44391236 129901 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 357 1 1 4 4.3 N=c1c2ccsc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL361149 129901 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 357 1 1 4 4.3 N=c1c2ccsc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
11360133 130098 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 351 1 1 3 4.2 N=c1c2ccccc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL361606 130098 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 351 1 1 3 4.2 N=c1c2ccccc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
44389704 69277 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 509 5 0 3 6.7 CC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL178136 69277 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 509 5 0 3 6.7 CC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44391252 72618 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 397 2 1 4 5.2 N=c1c2c(C3CC3)csc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL183520 72618 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 397 2 1 4 5.2 N=c1c2c(C3CC3)csc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
44391317 72276 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 336 2 0 2 5.7 C(=C1\CCN2Cc3ccccc3N=C12)\c1ccccc1-c1ccccc1 10.1016/j.bmcl.2004.11.039
CHEMBL183052 72276 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 336 2 0 2 5.7 C(=C1\CCN2Cc3ccccc3N=C12)\c1ccccc1-c1ccccc1 10.1016/j.bmcl.2004.11.039
44400990 173030 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 454 7 2 3 5.5 CC(C)CC(CNC(=O)Nc1cc(Cl)cc(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
CHEMBL426822 173030 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 454 7 2 3 5.5 CC(C)CC(CNC(=O)Nc1cc(Cl)cc(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
11466397 69653 0 None -407 4 Rat 5.5 pKi = 5.5 Binding
In vitro binding affinity against rat CC chemokine receptor 3In vitro binding affinity against rat CC chemokine receptor 3
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178447 69653 0 None -407 4 Rat 5.5 pKi = 5.5 Binding
In vitro binding affinity against rat CC chemokine receptor 3In vitro binding affinity against rat CC chemokine receptor 3
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
71451392 88049 0 None 31 2 Human 8.5 pKi = 8.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 C[C@](Cc1ccccc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158786 88049 0 None 31 2 Human 8.5 pKi = 8.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 C[C@](Cc1ccccc1)(C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
71458868 89007 0 None 6 2 Human 8.5 pKi = 8.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 568 6 1 6 4.8 Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)NS(=O)(=O)c4ccc(N(C)C)cc4)CC3)CC2)c1Cl 10.1016/j.bmcl.2012.08.124
CHEMBL2171014 89007 0 None 6 2 Human 8.5 pKi = 8.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 568 6 1 6 4.8 Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)NS(=O)(=O)c4ccc(N(C)C)cc4)CC3)CC2)c1Cl 10.1016/j.bmcl.2012.08.124
59295958 90787 0 None 1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 507 7 3 5 3.6 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccc(F)cc12 10.1016/j.bmcl.2012.09.112
CHEMBL2207280 90787 0 None 1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 507 7 3 5 3.6 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccc(F)cc12 10.1016/j.bmcl.2012.09.112
59296100 90863 0 None 7 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 460 7 3 5 3.0 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]nc2C(F)(F)F)CC1 10.1016/j.bmcl.2012.09.112
CHEMBL2207659 90863 0 None 7 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 460 7 3 5 3.0 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]nc2C(F)(F)F)CC1 10.1016/j.bmcl.2012.09.112
59296090 90867 0 None 1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 507 7 3 5 3.3 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)cc1C(F)(F)F 10.1016/j.bmcl.2012.09.112
CHEMBL2207662 90867 0 None 1 2 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 507 7 3 5 3.3 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)cc1C(F)(F)F 10.1016/j.bmcl.2012.09.112
10653 9068 12 None - 1 Human 8.5 pKi = 8.5 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 511 6 1 5 3.6 O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C nan
59534386 9068 12 None - 1 Human 8.5 pKi = 8.5 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 511 6 1 5 3.6 O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C nan
CHEMBL3670800 9068 12 None - 1 Human 8.5 pKi = 8.5 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 511 6 1 5 3.6 O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C nan
DB15269 9068 12 None - 1 Human 8.5 pKi = 8.5 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 511 6 1 5 3.6 O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C nan
11466397 69653 0 None -1 4 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178447 69653 0 None -1 4 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
11466397 69653 0 None -1 4 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178447 69653 0 None -1 4 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
56966926 136057 0 None - 1 Human 8.5 pKi = 8.5 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 537 8 2 5 4.1 Cc1cc(C(=O)NCC2CC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670804 136057 0 None - 1 Human 8.5 pKi = 8.5 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 537 8 2 5 4.1 Cc1cc(C(=O)NCC2CC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
71072104 88038 0 None 15 2 Human 8.4 pKi = 8.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 520 9 1 5 5.3 COc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158775 88038 0 None 15 2 Human 8.4 pKi = 8.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 520 9 1 5 5.3 COc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
66615678 88043 0 None 19 2 Human 8.4 pKi = 8.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 488 8 1 4 5.0 Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158780 88043 0 None 19 2 Human 8.4 pKi = 8.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 488 8 1 4 5.0 Cc1cc(Cl)ccc1OC1CCN(CC2CCN([C@@H](Cc3ccc(F)cc3)C(=O)O)CC2)CC1 10.1016/j.bmcl.2012.08.103
59296039 90985 0 None 15 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 467 8 3 6 3.2 COc1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)ccc1N 10.1016/j.bmcl.2012.09.113
CHEMBL2208427 90985 0 None 15 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 467 8 3 6 3.2 COc1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)ccc1N 10.1016/j.bmcl.2012.09.113
59295984 90786 0 None 3 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 487 7 3 5 3.3 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(F)ccc23)CC1 10.1016/j.bmcl.2012.09.112
CHEMBL2207279 90786 0 None 3 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 487 7 3 5 3.3 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3cc(F)ccc23)CC1 10.1016/j.bmcl.2012.09.112
59296048 90791 0 None 6 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 582 9 4 7 2.4 CNS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
CHEMBL2207284 90791 0 None 6 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 582 9 4 7 2.4 CNS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
59295969 90792 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 608 10 4 7 2.9 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NC3CC3)ccc12 10.1016/j.bmcl.2012.09.112
CHEMBL2207285 90792 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 608 10 4 7 2.9 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2cc(S(=O)(=O)NC3CC3)ccc12 10.1016/j.bmcl.2012.09.112
71454296 90870 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 521 7 2 6 3.3 Cn1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c(C(F)(F)F)cc1=O 10.1016/j.bmcl.2012.09.112
CHEMBL2207665 90870 0 None 1 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 521 7 2 6 3.3 Cn1cc(C(=O)NC[C@@H](O)CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c(C(F)(F)F)cc1=O 10.1016/j.bmcl.2012.09.112
59296094 90874 0 None 31 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 480 7 3 6 2.7 N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1Cl 10.1016/j.bmcl.2012.09.112
CHEMBL2207669 90874 0 None 31 2 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 480 7 3 6 2.7 N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1Cl 10.1016/j.bmcl.2012.09.112
44389737 130640 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1ccc2ncccc2c1)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL362649 130640 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1ccc2ncccc2c1)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
66906657 122800 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355942 122800 0 None 12 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
68849581 88064 0 None 3 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 478 7 1 5 4.4 O=C(O)C(c1ccccc1)N1CCO[C@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2012.08.103
CHEMBL2158818 88064 0 None 3 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 478 7 1 5 4.4 O=C(O)C(c1ccccc1)N1CCO[C@H](CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2012.08.103
69348078 88066 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)[C@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158820 88066 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)[C@H](c1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
69272932 88074 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 492 8 1 5 5.2 O=C(O)COc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158828 88074 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 492 8 1 5 5.2 O=C(O)COc1ccccc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
71072034 88083 0 None 3 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 490 8 1 4 5.2 O=C(O)[C@@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158836 88083 0 None 3 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 490 8 1 4 5.2 O=C(O)[C@@H](Cc1ccccc1)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
17963208 89028 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 529 5 1 5 4.5 O=C(NS(=O)(=O)c1ccc(F)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171034 89028 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 529 5 1 5 4.5 O=C(NS(=O)(=O)c1ccc(F)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
71453505 89035 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 554 6 1 6 4.5 CN(C)c1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171041 89035 0 None -1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 554 6 1 6 4.5 CN(C)c1ccccc1S(=O)(=O)NC(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
17963347 89039 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 579 5 1 5 5.4 O=C(NS(=O)(=O)c1cccc(C(F)(F)F)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171045 89039 0 None 1 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 579 5 1 5 5.4 O=C(NS(=O)(=O)c1cccc(C(F)(F)F)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
71452601 90982 0 None -100 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 434 8 1 5 4.5 N#Cc1cccc(OC[C@@H](O)CCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
CHEMBL2208424 90982 0 None -100 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 434 8 1 5 4.5 N#Cc1cccc(OC[C@@H](O)CCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
59296098 90873 0 None 15 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 446 7 3 6 2.0 N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1 10.1016/j.bmcl.2012.09.112
CHEMBL2207668 90873 0 None 15 2 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 446 7 3 6 2.0 N#Cc1ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]c(=O)c4ccccc34)CC2)cc1 10.1016/j.bmcl.2012.09.112
44391213 129642 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 365 1 0 3 4.3 C/N=c1/c2ccccc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL360560 129642 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 365 1 0 3 4.3 C/N=c1/c2ccccc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
118721198 122806 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(C(N)=O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355948 122806 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(C(N)=O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44401177 75175 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 490 9 1 4 5.9 CN(C)c1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL191693 75175 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 490 9 1 4 5.9 CN(C)c1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401182 77844 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 476 7 2 3 6.0 Cc1cc(C)cc(NC(=O)NCC(CC(C)C)N2CCN(c3ccc(Cl)c(Cl)c3)CC2)c1 10.1021/jm040827u
CHEMBL195202 77844 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 476 7 2 3 6.0 Cc1cc(C)cc(NC(=O)NCC(CC(C)C)N2CCN(c3ccc(Cl)c(Cl)c3)CC2)c1 10.1021/jm040827u
25056325 77952 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 496 7 2 3 6.5 Cc1ccc(NC(=O)NCC(c2ccc(-c3ccccc3)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL195610 77952 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 496 7 2 3 6.5 Cc1ccc(NC(=O)NCC(c2ccc(-c3ccccc3)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
136229178 89019 0 None -19 2 Human 6.5 pKi = 6.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 516 5 1 6 4.5 O=C(c1ccc(-c2noc(=O)[nH]2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171025 89019 0 None -19 2 Human 6.5 pKi = 6.5 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 516 5 1 6 4.5 O=C(c1ccc(-c2noc(=O)[nH]2)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
71452602 90994 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 433 8 2 5 3.9 N#Cc1cccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
CHEMBL2208436 90994 0 None 1 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 433 8 2 5 3.9 N#Cc1cccc(OC[C@@H](O)CNC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
118721185 122792 0 None 1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355934 122792 0 None 1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721204 122822 0 None -28 3 Rat 6.5 pKi = 6.5 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 532 9 3 2 6.7 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)[nH]c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355964 122822 0 None -28 3 Rat 6.5 pKi = 6.5 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 532 9 3 2 6.7 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)[nH]c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
44391329 129118 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 344 2 0 3 4.9 FC(F)(F)Oc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
CHEMBL359918 129118 0 None - 1 Human 5.5 pKi = 5.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 344 2 0 3 4.9 FC(F)(F)Oc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
11477767 69801 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL178818 69801 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44400948 77846 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 510 7 2 3 6.8 Cc1cc(C)cc(NC(=O)NCC(c2ccc(-c3ccccc3)cc2)N2CCN(C3CCCCC3)CC2)c1 10.1021/jm040827u
CHEMBL195214 77846 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 510 7 2 3 6.8 Cc1cc(C)cc(NC(=O)NCC(c2ccc(-c3ccccc3)cc2)N2CCN(C3CCCCC3)CC2)c1 10.1021/jm040827u
118721189 122796 0 None 1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 400 6 1 2 6.1 Cc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355938 122796 0 None 1 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 400 6 1 2 6.1 Cc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44389738 71245 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 525 6 0 4 6.1 CCO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL181379 71245 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 525 6 0 4 6.1 CCO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
118721206 122824 0 None -97 3 Rat 5.5 pKi = 5.5 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 667 11 2 6 7.3 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)OC)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355966 122824 0 None -97 3 Rat 5.5 pKi = 5.5 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 667 11 2 6 7.3 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)OC)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
44389868 71413 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 588 7 1 5 4.9 CS(=O)(=O)NC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL181789 71413 0 None - 1 Human 6.5 pKi = 6.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 588 7 1 5 4.9 CS(=O)(=O)NC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44401160 76240 0 None - 1 Human 5.5 pKi = 5.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 436 6 2 4 3.8 COc1ccccc1NC(=O)NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C)CC1 10.1021/jm040827u
CHEMBL193369 76240 0 None - 1 Human 5.5 pKi = 5.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 436 6 2 4 3.8 COc1ccccc1NC(=O)NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C)CC1 10.1021/jm040827u
118721206 122824 0 None 19 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 667 11 2 6 7.3 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)OC)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355966 122824 0 None 19 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 667 11 2 6 7.3 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)OC)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
44389784 71099 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3cnc4ccccc4n3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL181137 71099 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3cnc4ccccc4n3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44401083 131317 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.8 COc1ccccc1C(CNCCc1cc(Cl)cc(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
CHEMBL364047 131317 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.8 COc1ccccc1C(CNCCc1cc(Cl)cc(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
44401154 77039 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 477 9 1 4 5.8 COc1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL194161 77039 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 477 9 1 4 5.8 COc1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401031 76810 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 503 8 1 3 7.1 CC(C)(C)c1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL193973 76810 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 503 8 1 3 7.1 CC(C)(C)c1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401011 142018 0 None - 1 Human 4.5 pKi = 4.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 510 8 1 4 5.0 CN(C)c1ccc(C(CNC(=O)Cc2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL372493 142018 0 None - 1 Human 4.5 pKi = 4.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 510 8 1 4 5.0 CN(C)c1ccc(C(CNC(=O)Cc2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
44391247 130275 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 307 1 1 3 4.1 N=c1c2ccccc2nc2n1CC/C2=C\c1ccccc1Cl 10.1016/j.bmcl.2004.11.039
CHEMBL361761 130275 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 307 1 1 3 4.1 N=c1c2ccccc2nc2n1CC/C2=C\c1ccccc1Cl 10.1016/j.bmcl.2004.11.039
44389910 70130 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4cnccc4n3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL179490 70130 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4cnccc4n3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
44391177 71243 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 411 1 1 4 5.2 N=c1c2c3c(sc2nc2n1CC/C2=C\c1ccccc1Br)CCCC3 10.1016/j.bmcl.2004.11.039
CHEMBL181367 71243 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 411 1 1 4 5.2 N=c1c2c3c(sc2nc2n1CC/C2=C\c1ccccc1Br)CCCC3 10.1016/j.bmcl.2004.11.039
44401206 133834 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 447 8 1 3 5.8 CC(C)(C)c1ccc(C(CNCCc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL365596 133834 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 447 8 1 3 5.8 CC(C)(C)c1ccc(C(CNCCc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
118721205 122823 0 None -870 3 Rat 5.5 pKi = 5.5 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 653 11 3 5 7.2 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)O)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355965 122823 0 None -870 3 Rat 5.5 pKi = 5.5 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 653 11 3 5 7.2 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)O)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
44401063 139877 0 None - 1 Human 5.5 pKi = 5.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 444 7 2 4 4.7 COc1ccccc1C(CNC(=O)Nc1ccc(C)cc1)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
CHEMBL370244 139877 0 None - 1 Human 5.5 pKi = 5.5 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 444 7 2 4 4.7 COc1ccccc1C(CNC(=O)Nc1ccc(C)cc1)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
44391192 70661 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 301 2 1 3 4.0 CCc1ccccc1/C=C1\CCn2c1nc1ccccc1c2=N 10.1016/j.bmcl.2004.11.039
CHEMBL180446 70661 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 301 2 1 3 4.0 CCc1ccccc1/C=C1\CCn2c1nc1ccccc1c2=N 10.1016/j.bmcl.2004.11.039
44401248 142765 0 None - 1 Human 5.4 pKi = 5.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.5 COc1ccccc1NC(=O)NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
CHEMBL373158 142765 0 None - 1 Human 5.4 pKi = 5.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.5 COc1ccccc1NC(=O)NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
118721189 122796 0 None -1 3 Mouse 7.4 pKi = 7.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 400 6 1 2 6.1 Cc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355938 122796 0 None -1 3 Mouse 7.4 pKi = 7.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 400 6 1 2 6.1 Cc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721196 122804 0 None -4 3 Mouse 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355946 122804 0 None -4 3 Mouse 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721197 122805 0 None -19 2 Rat 5.4 pKi = 5.4 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(OC)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355947 122805 0 None -19 2 Rat 5.4 pKi = 5.4 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(OC)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
57718829 122808 0 None 2 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 428 7 0 3 6.4 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1C 10.1016/j.bmcl.2014.11.063
CHEMBL3355950 122808 0 None 2 2 Human 7.4 pKi = 7.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 428 7 0 3 6.4 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1C 10.1016/j.bmcl.2014.11.063
44389752 70882 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1ccnc2ccccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL180813 70882 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1ccnc2ccccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
118721198 122806 0 None -1 2 Mouse 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(C(N)=O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355948 122806 0 None -1 2 Mouse 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(C(N)=O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44400950 75442 0 None - 1 Human 5.4 pKi = 5.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 449 6 2 4 4.2 CN1CCN(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(N(C)C)cc2)CC1 10.1021/jm040827u
CHEMBL192045 75442 0 None - 1 Human 5.4 pKi = 5.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 449 6 2 4 4.2 CN1CCN(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(N(C)C)cc2)CC1 10.1021/jm040827u
10151756 88061 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 462 6 1 4 5.1 O=C(O)C(c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158815 88061 0 None 1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 462 6 1 4 5.1 O=C(O)C(c1ccccc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
69274365 88072 1 None -7 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)Cc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
CHEMBL2158826 88072 1 None -7 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)Cc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
71449585 88075 0 None -7 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 492 8 1 5 5.2 O=C(O)COc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
CHEMBL2158829 88075 0 None -7 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 492 8 1 5 5.2 O=C(O)COc1cccc(N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.103
17963196 89030 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 541 6 1 6 4.4 COc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171036 89030 0 None -1 2 Human 7.4 pKi = 7.4 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 541 6 1 6 4.4 COc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
118721202 122820 0 None -77 3 Rat 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cc(C(=O)O)ccn1 10.1016/j.bmcl.2014.11.063
CHEMBL3355962 122820 0 None -77 3 Rat 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cc(C(=O)O)ccn1 10.1016/j.bmcl.2014.11.063
44391212 72617 0 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 303 2 1 4 3.5 COc1ccc(/C=C2\CCn3c2nc2ccccc2c3=N)cc1 10.1016/j.bmcl.2004.11.039
CHEMBL183519 72617 0 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 303 2 1 4 3.5 COc1ccc(/C=C2\CCn3c2nc2ccccc2c3=N)cc1 10.1016/j.bmcl.2004.11.039
44401088 173129 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 483 9 1 4 5.4 COc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL427357 173129 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 483 9 1 4 5.4 COc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
44389675 69635 0 None - 1 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 525 6 0 4 6.0 COC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL178438 69635 0 None - 1 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 525 6 0 4 6.0 COC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
71449859 89023 0 None -10 2 Human 6.4 pKi = 6.4 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 600 10 1 8 5.1 O=C(O)CCCCn1nnc(-c2ccc(C(=O)N3CCC(N4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)CC3)cc2)n1 10.1016/j.bmcl.2012.08.124
CHEMBL2171029 89023 0 None -10 2 Human 6.4 pKi = 6.4 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 600 10 1 8 5.1 O=C(O)CCCCn1nnc(-c2ccc(C(=O)N3CCC(N4CCC(Oc5ccc(Cl)c(Cl)c5)CC4)CC3)cc2)n1 10.1016/j.bmcl.2012.08.124
71462391 89026 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 554 6 1 6 3.9 CS(=O)(=O)c1cccc(C(=O)N2CC[C@@H](N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)[C@H](C(=O)O)C2)c1 10.1016/j.bmcl.2012.08.124
CHEMBL2171032 89026 0 None -1 2 Human 6.4 pKi = 6.4 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 554 6 1 6 3.9 CS(=O)(=O)c1cccc(C(=O)N2CC[C@@H](N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)[C@H](C(=O)O)C2)c1 10.1016/j.bmcl.2012.08.124
118721205 122823 0 None 67 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 653 11 3 5 7.2 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)O)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355965 122823 0 None 67 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 653 11 3 5 7.2 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)O)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
67115149 136061 0 None - 1 Human 8.4 pKi = 8.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 8 2 5 4.5 CCC(C)NC(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
CHEMBL3670808 136061 0 None - 1 Human 8.4 pKi = 8.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 8 2 5 4.5 CCC(C)NC(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
68028908 136070 0 None - 1 Human 8.4 pKi = 8.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 7 1 5 4.5 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)cc(C(C)C)n3)CC2)ccc1Cl nan
CHEMBL3670817 136070 0 None - 1 Human 8.4 pKi = 8.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 7 1 5 4.5 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)cc(C(C)C)n3)CC2)ccc1Cl nan
68029259 136064 0 None - 1 Human 8.4 pKi = 8.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 537 7 2 5 4.2 Cc1cc(C(=O)NC2CCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670811 136064 0 None - 1 Human 8.4 pKi = 8.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 537 7 2 5 4.2 Cc1cc(C(=O)NC2CCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
118721191 122798 0 None 12 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 444 8 1 3 6.5 COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355940 122798 0 None 12 3 Human 8.4 pKi = 8.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 444 8 1 3 6.5 COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
67115103 136059 0 None - 1 Human 8.4 pKi = 8.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 8 2 5 4.3 Cc1cc(C(=O)NCC(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670806 136059 0 None - 1 Human 8.4 pKi = 8.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 539 8 2 5 4.3 Cc1cc(C(=O)NCC(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
56966996 136060 0 None - 1 Human 8.3 pKi = 8.3 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 547 8 2 5 3.9 Cc1cc(C(=O)NCC(F)F)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670807 136060 0 None - 1 Human 8.3 pKi = 8.3 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 547 8 2 5 3.9 Cc1cc(C(=O)NCC(F)F)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
118721200 122812 0 None 15 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 558 9 1 6 7.0 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(-c2nnn[nH]2)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355954 122812 0 None 15 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 558 9 1 6 7.0 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(-c2nnn[nH]2)cc1 10.1016/j.bmcl.2014.11.063
67115023 136054 0 None - 1 Human 8.3 pKi = 8.3 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 523 6 1 5 3.9 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N4CCCC4)ccn3)CC2)ccc1Cl nan
CHEMBL3670801 136054 0 None - 1 Human 8.3 pKi = 8.3 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 523 6 1 5 3.9 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N4CCCC4)ccn3)CC2)ccc1Cl nan
118721194 122802 0 None 5 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 426 8 1 3 6.4 COC(C)c1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355944 122802 0 None 5 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 426 8 1 3 6.4 COC(C)c1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
11952526 122811 0 None 24 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 534 9 1 4 7.5 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355953 122811 0 None 24 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 534 9 1 4 7.5 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
44389744 130651 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL362700 130651 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
66906657 122800 0 None -12 2 Mouse 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355942 122800 0 None -12 2 Mouse 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721199 122807 0 None -2 2 Human 5.4 pKi = 5.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 440 8 2 3 5.9 CCc1[nH]c2cc(C(=O)O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355949 122807 0 None -2 2 Human 5.4 pKi = 5.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 440 8 2 3 5.9 CCc1[nH]c2cc(C(=O)O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721188 122795 0 None -8 3 Rat 5.4 pKi = 5.4 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C(N)=O)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355937 122795 0 None -8 3 Rat 5.4 pKi = 5.4 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C(N)=O)cc2)CC1 10.1016/j.bmcl.2014.11.063
44401189 76618 0 None - 1 Human 4.4 pKi = 4.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 429 8 1 4 3.9 COc1ccc(C(CNC(=O)Cc2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL193818 76618 0 None - 1 Human 4.4 pKi = 4.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 429 8 1 4 3.9 COc1ccc(C(CNC(=O)Cc2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
44391800 71047 0 None - 1 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 484 6 0 3 4.9 COc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Br)cc3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL180939 71047 0 None - 1 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 484 6 0 3 4.9 COc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Br)cc3)CC2)CC1 10.1016/j.bmcl.2005.01.016
44389675 69635 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 525 6 0 4 6.0 COC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL178438 69635 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 525 6 0 4 6.0 COC[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
25024850 122819 0 None -6 3 Mouse 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1cccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)n1 10.1016/j.bmcl.2014.11.063
CHEMBL3355961 122819 0 None -6 3 Mouse 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1cccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)n1 10.1016/j.bmcl.2014.11.063
68028909 136068 0 None - 1 Human 6.4 pKi = 6.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 553 9 1 5 4.7 CCCCc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670815 136068 0 None - 1 Human 6.4 pKi = 6.4 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 553 9 1 5 4.7 CCCCc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
118721195 122803 0 None -9 3 Rat 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(C)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355945 122803 0 None -9 3 Rat 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(C)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44400977 76731 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 420 7 2 3 4.8 CC(C)CC(CNC(=O)Nc1ccc(Cl)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
CHEMBL193916 76731 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 420 7 2 3 4.8 CC(C)CC(CNC(=O)Nc1ccc(Cl)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
44400944 77091 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 442 9 1 4 4.8 Cc1ccc(CCNCC(c2ccc(N(C)C)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL194435 77091 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 442 9 1 4 4.8 Cc1ccc(CCNCC(c2ccc(N(C)C)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
118721188 122795 0 None 2 3 Human 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C(N)=O)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355937 122795 0 None 2 3 Human 6.4 pKi = 6.4 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 439 8 2 3 5.3 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C(N)=O)cc2)CC1 10.1016/j.bmcl.2014.11.063
44391312 72361 0 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 304 3 0 3 4.4 CCOc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
CHEMBL183229 72361 0 None - 1 Human 5.4 pKi = 5.4 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 304 3 0 3 4.4 CCOc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
44389735 129102 0 None - 1 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1cnc2ccccc2c1)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL359850 129102 0 None - 1 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1cnc2ccccc2c1)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
118721195 122803 0 None 1 3 Human 7.3 pKi = 7.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(C)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355945 122803 0 None 1 3 Human 7.3 pKi = 7.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(C)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44389736 69610 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 513 5 0 3 6.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CF)C2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178422 69610 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 513 5 0 3 6.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CF)C2)CC1 10.1016/j.bmcl.2005.01.016
44389725 130433 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 482 4 0 4 5.5 O=C(c1cnnc2ccccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL362017 130433 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 482 4 0 4 5.5 O=C(c1cnnc2ccccc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
56966927 136047 0 None - 1 Human 7.3 pKi = 7.3 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 456 6 1 5 3.6 COc1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
CHEMBL3670793 136047 0 None - 1 Human 7.3 pKi = 7.3 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 456 6 1 5 3.6 COc1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
118721193 122801 0 None -69 3 Rat 5.3 pKi = 5.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 398 7 2 3 5.2 OCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355943 122801 0 None -69 3 Rat 5.3 pKi = 5.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 398 7 2 3 5.2 OCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
11952525 122816 0 None -38 3 Rat 5.3 pKi = 5.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 562 10 0 5 8.0 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355958 122816 0 None -38 3 Rat 5.3 pKi = 5.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 562 10 0 5 8.0 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)cc1 10.1016/j.bmcl.2014.11.063
44401129 133555 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 391 7 1 3 3.8 CN1CCN(C(CNCCc2ccccc2)c2ccc(C(F)(F)F)cc2)CC1 10.1021/jm040827u
CHEMBL365369 133555 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 391 7 1 3 3.8 CN1CCN(C(CNCCc2ccccc2)c2ccc(C(F)(F)F)cc2)CC1 10.1021/jm040827u
44401175 134009 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.5 COc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL365806 134009 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.5 COc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401037 77855 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 474 6 2 3 5.5 O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1ccccc1 10.1021/jm040827u
CHEMBL195291 77855 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 474 6 2 3 5.5 O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1ccccc1 10.1021/jm040827u
118721195 122803 0 None -1 3 Mouse 7.3 pKi = 7.3 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(C)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355945 122803 0 None -1 3 Mouse 7.3 pKi = 7.3 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(C)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44389765 176115 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4nccnc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL441848 176115 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4nccnc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
118721192 122799 0 None -4 2 Human 6.3 pKi = 6.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 458 8 1 4 6.0 CCOC(=O)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355941 122799 0 None -4 2 Human 6.3 pKi = 6.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 458 8 1 4 6.0 CCOC(=O)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44401146 77036 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 459 8 1 3 5.5 FC(F)(F)c1ccc(C(CNCCc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL194135 77036 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 459 8 1 3 5.5 FC(F)(F)c1ccc(C(CNCCc2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401256 78009 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 471 9 1 4 5.7 COc1ccccc1CCNCC(c1ccc(C(C)(C)C)cc1)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
CHEMBL195657 78009 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 471 9 1 4 5.7 COc1ccccc1CCNCC(c1ccc(C(C)(C)C)cc1)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
25024650 122818 0 None 21 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cccc(C(=O)O)n1 10.1016/j.bmcl.2014.11.063
CHEMBL3355960 122818 0 None 21 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cccc(C(=O)O)n1 10.1016/j.bmcl.2014.11.063
118721202 122820 0 None 15 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cc(C(=O)O)ccn1 10.1016/j.bmcl.2014.11.063
CHEMBL3355962 122820 0 None 15 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cc(C(=O)O)ccn1 10.1016/j.bmcl.2014.11.063
9914506 88032 0 None 3 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 515 8 1 5 5.1 N#Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158769 88032 0 None 3 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 515 8 1 5 5.1 N#Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
68938028 88035 0 None 6 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158772 88035 0 None 6 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 8 1 4 5.6 Cc1ccccc1C[C@@H](C(=O)O)N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
66615705 88042 0 None 19 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 508 8 1 4 5.4 O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3Cl)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158779 88042 0 None 19 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 508 8 1 4 5.4 O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3Cl)CC2)CC1 10.1016/j.bmcl.2012.08.103
69826668 89015 0 None 5 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 524 5 0 5 4.9 Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)c4cccc(S(C)(=O)=O)c4)CC3)CC2)c1Cl 10.1016/j.bmcl.2012.08.124
CHEMBL2171021 89015 0 None 5 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 524 5 0 5 4.9 Cc1c(Cl)ccc(OC2CCN(C3CCN(C(=O)c4cccc(S(C)(=O)=O)c4)CC3)CC2)c1Cl 10.1016/j.bmcl.2012.08.124
71457010 89033 0 None 10 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 545 5 1 5 5.1 O=C(NS(=O)(=O)c1ccccc1Cl)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171039 89033 0 None 10 2 Human 8.3 pKi = 8.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 545 5 1 5 5.1 O=C(NS(=O)(=O)c1ccccc1Cl)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
70790202 136062 0 None - 1 Human 8.3 pKi = 8.3 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 553 8 1 5 4.8 CCC(C)N(C)C(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
CHEMBL3670809 136062 0 None - 1 Human 8.3 pKi = 8.3 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 553 8 1 5 4.8 CCC(C)N(C)C(=O)c1cc(C)nc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
57718837 122790 0 None 1 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 414 7 1 2 6.4 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355932 122790 0 None 1 3 Human 8.2 pKi = 8.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 414 7 1 2 6.4 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
56966997 136065 0 None - 1 Human 8.2 pKi = 8.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 555 6 1 5 3.8 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Br)c(C)c3)CC2)n1 nan
CHEMBL3670812 136065 0 None - 1 Human 8.2 pKi = 8.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 555 6 1 5 3.8 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Br)c(C)c3)CC2)n1 nan
11466397 69653 0 None -1 4 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178447 69653 0 None -1 4 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
10003872 77057 0 None - 1 Human 7.3 pKi = 7.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 449 9 1 4 5.1 COc1ccc(C(CNCCc2cc(C)cc(C)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL194283 77057 0 None - 1 Human 7.3 pKi = 7.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 449 9 1 4 5.1 COc1ccc(C(CNCCc2cc(C)cc(C)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
71451390 88041 0 None 7 2 Human 7.3 pKi = 7.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 474 8 1 4 4.7 O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158778 88041 0 None 7 2 Human 7.3 pKi = 7.3 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 474 8 1 4 4.7 O=C(O)[C@H](Cc1ccc(F)cc1)N1CCC(CN2CCC(Oc3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2012.08.103
22397436 89012 0 None -6 2 Human 7.3 pKi = 7.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 510 5 0 5 4.5 CS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
CHEMBL2171019 89012 0 None -6 2 Human 7.3 pKi = 7.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 510 5 0 5 4.5 CS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
17963258 89031 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 554 6 1 6 4.5 CN(C)c1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171037 89031 0 None -2 2 Human 7.3 pKi = 7.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 554 6 1 6 4.5 CN(C)c1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
71451671 89022 0 None -31 2 Human 6.3 pKi = 6.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 519 8 2 5 5.0 O=C(O)CCNc1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171028 89022 0 None -31 2 Human 6.3 pKi = 6.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 519 8 2 5 5.0 O=C(O)CCNc1ccccc1C(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
71451670 89010 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 455 7 1 4 4.2 COc1ccc(C(=O)NCCN2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)cc1Cl 10.1016/j.bmcl.2012.08.124
CHEMBL2171017 89010 0 None - 1 Human 5.3 pKi = 5.3 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 455 7 1 4 4.2 COc1ccc(C(=O)NCCN2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)cc1Cl 10.1016/j.bmcl.2012.08.124
44389751 71418 0 None - 1 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 442 5 0 2 5.3 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(F)cc(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL181794 71418 0 None - 1 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 442 5 0 2 5.3 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(F)cc(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
44401136 77551 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 495 9 1 3 6.8 Cc1cc(C)cc(CCNCC(c2ccc(-c3ccccc3)cc2)N2CCN(C3CCCCC3)CC2)c1 10.1021/jm040827u
CHEMBL195081 77551 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 495 9 1 3 6.8 Cc1cc(C)cc(CCNCC(c2ccc(-c3ccccc3)cc2)N2CCN(C3CCCCC3)CC2)c1 10.1021/jm040827u
44401132 75411 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 474 5 2 3 5.1 CN1CCN(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(C(F)(F)F)cc2)CC1 10.1021/jm040827u
CHEMBL191824 75411 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 474 5 2 3 5.1 CN1CCN(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)c2ccc(C(F)(F)F)cc2)CC1 10.1021/jm040827u
118721191 122798 0 None -12 3 Mouse 7.3 pKi = 7.3 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 444 8 1 3 6.5 COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355940 122798 0 None -12 3 Mouse 7.3 pKi = 7.3 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 444 8 1 3 6.5 COC(C)c1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
25024849 122817 0 None -97 3 Rat 5.3 pKi = 5.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)nc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355959 122817 0 None -97 3 Rat 5.3 pKi = 5.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)nc1 10.1016/j.bmcl.2014.11.063
44401012 75445 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 454 7 2 4 4.6 COc1ccccc1C(CNC(=O)Nc1ccc(F)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
CHEMBL192066 75445 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 454 7 2 4 4.6 COc1ccccc1C(CNC(=O)Nc1ccc(F)cc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
44401145 77012 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 420 6 2 3 4.8 Cc1ccc(NC(=O)NCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL194086 77012 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 420 6 2 3 4.8 Cc1ccc(NC(=O)NCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
25024849 122817 0 None 13 3 Human 7.3 pKi = 7.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)nc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355959 122817 0 None 13 3 Human 7.3 pKi = 7.3 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)nc1 10.1016/j.bmcl.2014.11.063
44401048 76624 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 473 8 1 3 5.8 Cc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL193828 76624 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 473 8 1 3 5.8 Cc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
11952526 122811 0 None -1122 3 Rat 5.3 pKi = 5.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 534 9 1 4 7.5 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355953 122811 0 None -1122 3 Rat 5.3 pKi = 5.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 534 9 1 4 7.5 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
44401209 76579 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 418 6 2 3 4.5 O=C(NCC(c1ccccc1)N1CCN(c2ccccc2)CC1)Nc1ccc(F)cc1 10.1021/jm040827u
CHEMBL193592 76579 0 None - 1 Human 5.3 pKi = 5.3 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 418 6 2 3 4.5 O=C(NCC(c1ccccc1)N1CCN(c2ccccc2)CC1)Nc1ccc(F)cc1 10.1021/jm040827u
44389683 138428 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)cc3Cl)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL369287 138428 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Cl)cc3Cl)CC2)CC1 10.1016/j.bmcl.2005.01.016
118721196 122804 0 None -6 3 Rat 6.3 pKi = 6.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355946 122804 0 None -6 3 Rat 6.3 pKi = 6.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
24937215 122810 0 None -9 3 Rat 6.3 pKi = 6.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 472 9 1 4 5.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1CC(=O)O 10.1016/j.bmcl.2014.11.063
CHEMBL3355952 122810 0 None -9 3 Rat 6.3 pKi = 6.3 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 472 9 1 4 5.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1CC(=O)O 10.1016/j.bmcl.2014.11.063
44401226 77882 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 429 9 1 4 4.7 COc1ccc(C(CNCCc2ccc(C)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL195406 77882 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 429 9 1 4 4.7 COc1ccc(C(CNCCc2ccc(C)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
56966929 136053 0 None - 1 Human 8.2 pKi = 8.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 553 6 1 6 3.4 Cc1cc(C(=O)N2CCOCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670799 136053 0 None - 1 Human 8.2 pKi = 8.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 553 6 1 6 3.4 Cc1cc(C(=O)N2CCOCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
11753159 7335 6 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2012.08.103
7679 7335 6 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2012.08.103
CHEMBL2158814 7335 6 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2012.08.103
11753159 7335 6 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2012.08.124
7679 7335 6 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2012.08.124
CHEMBL2158814 7335 6 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 10.1016/j.bmcl.2012.08.124
17963183 89037 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 545 5 1 5 5.1 O=C(NS(=O)(=O)c1cccc(Cl)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171043 89037 0 None 1 2 Human 8.2 pKi = 8.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 545 5 1 5 5.1 O=C(NS(=O)(=O)c1cccc(Cl)c1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
59296024 90784 0 None 9 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 547 8 3 7 2.5 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3ccc(S(C)(=O)=O)cc23)CC1 10.1016/j.bmcl.2012.09.112
CHEMBL2207277 90784 0 None 9 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 547 8 3 7 2.5 Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3ccc(S(C)(=O)=O)cc23)CC1 10.1016/j.bmcl.2012.09.112
59296111 90862 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 480 7 3 5 3.4 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C(F)(F)F 10.1016/j.bmcl.2012.09.112
CHEMBL2207658 90862 0 None 2 2 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 480 7 3 5 3.4 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]nc1C(F)(F)F 10.1016/j.bmcl.2012.09.112
56966995 136058 0 None - 1 Human 8.2 pKi = 8.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 523 6 1 5 3.8 Cc1cc(C(=O)N2CCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670805 136058 0 None - 1 Human 8.2 pKi = 8.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 523 6 1 5 3.8 Cc1cc(C(=O)N2CCC2)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
118721184 122791 0 None 1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccccc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355933 122791 0 None 1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccccc2)CC1 10.1016/j.bmcl.2014.11.063
25024850 122819 0 None 6 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1cccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)n1 10.1016/j.bmcl.2014.11.063
CHEMBL3355961 122819 0 None 6 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1cccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)n1 10.1016/j.bmcl.2014.11.063
44401005 77346 0 None - 1 Human 5.2 pKi = 5.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 459 9 1 5 3.9 COc1ccccc1CC(=O)NCC(c1ccccc1OC)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
CHEMBL194886 77346 0 None - 1 Human 5.2 pKi = 5.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 459 9 1 5 3.9 COc1ccccc1CC(=O)NCC(c1ccccc1OC)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
44401025 76452 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 496 9 1 4 5.5 CN(C)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL193535 76452 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 496 9 1 4 5.5 CN(C)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
11466397 69653 0 None -83 4 Mouse 6.2 pKi = 6.2 Binding
In vitro binding affinity against mouse CC chemokine receptor 3In vitro binding affinity against mouse CC chemokine receptor 3
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178447 69653 0 None -83 4 Mouse 6.2 pKi = 6.2 Binding
In vitro binding affinity against mouse CC chemokine receptor 3In vitro binding affinity against mouse CC chemokine receptor 3
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
24937215 122810 0 None 1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 472 9 1 4 5.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1CC(=O)O 10.1016/j.bmcl.2014.11.063
CHEMBL3355952 122810 0 None 1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 472 9 1 4 5.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1CC(=O)O 10.1016/j.bmcl.2014.11.063
70790203 136076 0 None - 1 Human 7.2 pKi = 7.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 525 6 1 5 4.0 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3cc(C)c(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670823 136076 0 None - 1 Human 7.2 pKi = 7.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 525 6 1 5 4.0 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3cc(C)c(Cl)c(C)c3)CC2)n1 nan
44391235 72019 0 None - 1 Human 5.2 pKi = 5.2 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 376 1 0 4 4.1 N#C/N=c1/c2ccccc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL182719 72019 0 None - 1 Human 5.2 pKi = 5.2 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 376 1 0 4 4.1 N#C/N=c1/c2ccccc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
118721185 122792 0 None -1 3 Mouse 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355934 122792 0 None -1 3 Mouse 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C)cc2)CC1 10.1016/j.bmcl.2014.11.063
25056323 78011 0 None - 1 Human 7.2 pKi = 7.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.8 COc1ccc(C(CNCCc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL195671 78011 0 None - 1 Human 7.2 pKi = 7.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.8 COc1ccc(C(CNCCc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401069 75885 0 None - 1 Human 4.2 pKi = 4.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 473 7 1 3 5.3 O=C(Cc1cc(Cl)cc(Cl)c1)NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
CHEMBL192384 75885 0 None - 1 Human 4.2 pKi = 4.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 473 7 1 3 5.3 O=C(Cc1cc(Cl)cc(Cl)c1)NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
44401110 75429 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 477 9 1 4 5.8 COc1ccc(C(CNCCc2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL191959 75429 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 477 9 1 4 5.8 COc1ccc(C(CNCCc2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
59296041 90875 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 558 8 3 8 2.1 CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(C#N)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
CHEMBL2207670 90875 0 None 3 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 558 8 3 8 2.1 CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(C#N)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
25024651 122814 0 None -39 3 Mouse 6.2 pKi = 6.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
CHEMBL3355956 122814 0 None -39 3 Mouse 6.2 pKi = 6.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(C(=O)O)cn1 10.1016/j.bmcl.2014.11.063
118721185 122792 0 None -19 3 Rat 6.2 pKi = 6.2 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355934 122792 0 None -19 3 Rat 6.2 pKi = 6.2 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 410 7 1 2 6.5 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(C)cc2)CC1 10.1016/j.bmcl.2014.11.063
69347707 88080 1 None -5 2 Human 6.2 pKi = 6.2 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)c1ccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
CHEMBL2158833 88080 1 None -5 2 Human 6.2 pKi = 6.2 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)c1ccc(CN2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
69260079 88081 2 None -63 2 Human 6.2 pKi = 6.2 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 463 6 1 5 4.8 O=C(O)c1cccnc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
CHEMBL2158834 88081 2 None -63 2 Human 6.2 pKi = 6.2 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 463 6 1 5 4.8 O=C(O)c1cccnc1N1CCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.103
71457009 89024 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 5 1 4 5.2 Cc1ccc(C(=O)N2CCC(N3CC[C@H](Oc4ccc(Cl)c(C)c4Cl)C[C@@H]3C(=O)O)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171030 89024 0 None - 1 Human 6.2 pKi = 6.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 504 5 1 4 5.2 Cc1ccc(C(=O)N2CCC(N3CC[C@H](Oc4ccc(Cl)c(C)c4Cl)C[C@@H]3C(=O)O)CC2)cc1 10.1016/j.bmcl.2012.08.124
17963199 89045 0 None 1 2 Human 6.2 pKi = 6.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 493 5 1 5 3.7 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(F)c(F)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171050 89045 0 None 1 2 Human 6.2 pKi = 6.2 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 493 5 1 5 3.7 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(F)c(F)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
44401203 76905 0 None - 1 Human 5.2 pKi = 5.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 424 6 2 3 4.6 O=C(NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(F)cc1 10.1021/jm040827u
CHEMBL194026 76905 0 None - 1 Human 5.2 pKi = 5.2 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 424 6 2 3 4.6 O=C(NCC(c1ccccc1)N1CCN(C2CCCCC2)CC1)Nc1ccc(F)cc1 10.1021/jm040827u
118721204 122822 0 None -5 3 Mouse 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 532 9 3 2 6.7 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)[nH]c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355964 122822 0 None -5 3 Mouse 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 532 9 3 2 6.7 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)[nH]c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
25024850 122819 0 None -107 3 Rat 5.2 pKi = 5.2 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1cccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)n1 10.1016/j.bmcl.2014.11.063
CHEMBL3355961 122819 0 None -107 3 Rat 5.2 pKi = 5.2 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1cccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)n1 10.1016/j.bmcl.2014.11.063
118721184 122791 0 None -1 3 Mouse 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccccc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355933 122791 0 None -1 3 Mouse 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccccc2)CC1 10.1016/j.bmcl.2014.11.063
11952524 122809 0 None -9 3 Mouse 6.2 pKi = 6.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 490 8 0 3 7.8 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccccc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355951 122809 0 None -9 3 Mouse 6.2 pKi = 6.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 490 8 0 3 7.8 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccccc1 10.1016/j.bmcl.2014.11.063
118721193 122801 0 None 1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 398 7 2 3 5.2 OCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355943 122801 0 None 1 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 398 7 2 3 5.2 OCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44389684 69756 0 None - 1 Human 7.2 pKi = 7.2 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 468 5 0 2 5.2 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Br)cc3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178576 69756 0 None - 1 Human 7.2 pKi = 7.2 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 468 5 0 2 5.2 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3ccc(Br)cc3)CC2)CC1 10.1016/j.bmcl.2005.01.016
118721206 122824 0 None -19 3 Mouse 6.2 pKi = 6.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 667 11 2 6 7.3 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)OC)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355966 122824 0 None -19 3 Mouse 6.2 pKi = 6.2 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 667 11 2 6 7.3 CCNC(=O)N[C@@H](CCN1CCC(c2c(CC)n(-c3ccc(C(=O)OC)cn3)c3cc(F)ccc23)CC1)Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2014.11.063
11952524 122809 0 None 3 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 490 8 0 3 7.8 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccccc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355951 122809 0 None 3 3 Human 7.2 pKi = 7.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 490 8 0 3 7.8 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccccc1 10.1016/j.bmcl.2014.11.063
56966928 136048 0 None - 1 Human 7.2 pKi = 7.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 440 5 1 4 3.9 Cc1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
CHEMBL3670794 136048 0 None - 1 Human 7.2 pKi = 7.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 440 5 1 4 3.9 Cc1ccnc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)c1 nan
44389677 69862 0 None - 1 Human 7.2 pKi = 7.2 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1cccc2cccnc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178875 69862 0 None - 1 Human 7.2 pKi = 7.2 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 481 4 0 3 6.1 O=C(c1cccc2cccnc12)N1CCC(N2CCC(Cc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
56965997 136046 0 None - 1 Human 7.2 pKi = 7.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 440 5 1 4 3.9 Cc1cccc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670792 136046 0 None - 1 Human 7.2 pKi = 7.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 440 5 1 4 3.9 Cc1cccc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
118721201 122813 0 None -2 2 Human 5.2 pKi = 5.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 548 10 1 4 7.6 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1Cc1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355955 122813 0 None -2 2 Human 5.2 pKi = 5.2 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 548 10 1 4 7.6 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1Cc1ccc(C(=O)O)cc1 10.1016/j.bmcl.2014.11.063
11466397 69653 0 None 1 4 Rhesus macaque 8.1 pKi = 8.1 Binding
In vitro binding affinity against monkey CC chemokine receptor 3In vitro binding affinity against monkey CC chemokine receptor 3
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL178447 69653 0 None 1 4 Rhesus macaque 8.1 pKi = 8.1 Binding
In vitro binding affinity against monkey CC chemokine receptor 3In vitro binding affinity against monkey CC chemokine receptor 3
ChEMBL 511 5 1 4 5.3 O=C(c1ccc2ncccc2c1)N1CCC(N2CC[C@H](Cc3ccc(Cl)c(Cl)c3)[C@H](CO)C2)CC1 10.1016/j.bmcl.2005.01.016
11477767 69801 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL178818 69801 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 511 5 0 4 5.7 CO[C@@H]1CN(C2CCN(C(=O)c3ccc4ncccc4c3)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
67115945 136074 0 None - 1 Human 8.1 pKi = 8.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 525 7 1 5 3.9 CCc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)cc(C)n3)CC2)ccc1Cl nan
CHEMBL3670821 136074 0 None - 1 Human 8.1 pKi = 8.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 525 7 1 5 3.9 CCc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)cc(C)n3)CC2)ccc1Cl nan
56967065 136075 0 None - 1 Human 8.1 pKi = 8.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 521 6 1 5 3.3 C#Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670822 136075 0 None - 1 Human 8.1 pKi = 8.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 521 6 1 5 3.3 C#Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
71072052 88034 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 515 8 1 5 5.1 N#Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
CHEMBL2158771 88034 0 None 1 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 515 8 1 5 5.1 N#Cc1ccc(C[C@@H](C(=O)O)N2CCC(CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.103
71453204 88045 0 None 12 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 488 8 1 4 5.0 Cc1cc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl 10.1016/j.bmcl.2012.08.103
CHEMBL2158782 88045 0 None 12 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 488 8 1 4 5.0 Cc1cc(OC2CCN(CC3CCN([C@@H](Cc4ccc(F)cc4)C(=O)O)CC3)CC2)ccc1Cl 10.1016/j.bmcl.2012.08.103
17963363 89029 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 545 5 1 5 5.1 O=C(NS(=O)(=O)c1ccc(Cl)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
CHEMBL2171035 89029 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 545 5 1 5 5.1 O=C(NS(=O)(=O)c1ccc(Cl)cc1)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2012.08.124
17963226 89042 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 505 5 1 5 4.4 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4C)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171048 89042 0 None 3 2 Human 8.1 pKi = 8.1 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 505 5 1 5 4.4 Cc1ccc(S(=O)(=O)NC(=O)N2CCC(N3CCC(Oc4ccc(Cl)cc4C)CC3)CC2)cc1 10.1016/j.bmcl.2012.08.124
59295994 90992 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 489 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cc(=O)[nH]c2ccccc12 10.1016/j.bmcl.2012.09.113
CHEMBL2208434 90992 0 None -1 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 489 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1cc(=O)[nH]c2ccccc12 10.1016/j.bmcl.2012.09.113
59295925 90876 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 567 8 3 7 2.9 CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
CHEMBL2207671 90876 0 None 2 2 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation countingDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4-(methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting
ChEMBL 567 8 3 7 2.9 CS(=O)(=O)c1ccc2c(C(=O)NC[C@@H](O)CN3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)c[nH]c(=O)c2c1 10.1016/j.bmcl.2012.09.112
56966999 136071 0 None - 1 Human 7.2 pKi = 7.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 495 6 1 5 3.1 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(F)c(C)c3)CC2)n1 nan
CHEMBL3670818 136071 0 None - 1 Human 7.2 pKi = 7.2 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 495 6 1 5 3.1 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(F)c(C)c3)CC2)n1 nan
118721200 122812 0 None -15 3 Mouse 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 558 9 1 6 7.0 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(-c2nnn[nH]2)cc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355954 122812 0 None -15 3 Mouse 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 558 9 1 6 7.0 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1ccc(-c2nnn[nH]2)cc1 10.1016/j.bmcl.2014.11.063
67115364 131215 0 None - 1 Human 7.1 pKi = 7.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 483 6 2 5 3.0 CNC(=O)c1cccc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3639696 131215 0 None - 1 Human 7.1 pKi = 7.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 483 6 2 5 3.0 CNC(=O)c1cccc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
44391319 71112 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 328 1 0 2 5.3 Clc1ccc(/C=C2\CCN3Cc4ccccc4N=C23)cc1Cl 10.1016/j.bmcl.2004.11.039
CHEMBL181195 71112 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 328 1 0 2 5.3 Clc1ccc(/C=C2\CCN3Cc4ccccc4N=C23)cc1Cl 10.1016/j.bmcl.2004.11.039
118721190 122797 0 None -40 3 Rat 6.1 pKi = 6.1 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 416 7 2 3 5.3 OCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355939 122797 0 None -40 3 Rat 6.1 pKi = 6.1 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 416 7 2 3 5.3 OCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
24937215 122810 0 None -1 3 Mouse 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 472 9 1 4 5.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1CC(=O)O 10.1016/j.bmcl.2014.11.063
CHEMBL3355952 122810 0 None -1 3 Mouse 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 472 9 1 4 5.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1CC(=O)O 10.1016/j.bmcl.2014.11.063
25024849 122817 0 None -13 3 Mouse 6.1 pKi = 6.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)nc1 10.1016/j.bmcl.2014.11.063
CHEMBL3355959 122817 0 None -13 3 Mouse 6.1 pKi = 6.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)nc1 10.1016/j.bmcl.2014.11.063
44391170 72493 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 399 1 1 3 4.1 N=c1c2ccccc2nc2n1CC/C2=C\c1ccccc1I 10.1016/j.bmcl.2004.11.039
CHEMBL183461 72493 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 399 1 1 3 4.1 N=c1c2ccccc2nc2n1CC/C2=C\c1ccccc1I 10.1016/j.bmcl.2004.11.039
44400991 76588 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 471 9 1 4 5.7 COc1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL193633 76588 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 471 9 1 4 5.7 COc1ccc(CCNCC(c2ccc(C(C)(C)C)cc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
43957010 75412 9 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 399 6 2 4 3.0 CN1CCN(C(CNC(=O)Nc2ccc(F)cc2)c2ccc(N(C)C)cc2)CC1 10.1021/jm040827u
CHEMBL191828 75412 9 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 399 6 2 4 3.0 CN1CCN(C(CNC(=O)Nc2ccc(F)cc2)c2ccc(N(C)C)cc2)CC1 10.1021/jm040827u
118721186 122793 0 None 2 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(O)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355935 122793 0 None 2 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(O)cc2)CC1 10.1016/j.bmcl.2014.11.063
44401085 142280 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 527 8 1 3 6.5 FC(F)(F)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL372858 142280 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 527 8 1 3 6.5 FC(F)(F)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
118721202 122820 0 None -15 3 Mouse 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cc(C(=O)O)ccn1 10.1016/j.bmcl.2014.11.063
CHEMBL3355962 122820 0 None -15 3 Mouse 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 535 9 1 5 6.9 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1-c1cc(C(=O)O)ccn1 10.1016/j.bmcl.2014.11.063
68846936 88062 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)C(c1ccccc1)N1CCCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2012.08.103
CHEMBL2158816 88062 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 476 7 1 4 5.4 O=C(O)C(c1ccccc1)N1CCCC(CN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/j.bmcl.2012.08.103
23102733 89008 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 511 6 1 5 4.0 O=C(NS(=O)(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1)c1ccccc1 10.1016/j.bmcl.2012.08.124
CHEMBL2171015 89008 0 None 1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 511 6 1 5 4.0 O=C(NS(=O)(=O)N1CCC(N2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)CC1)c1ccccc1 10.1016/j.bmcl.2012.08.124
71449858 89021 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 582 9 1 6 4.8 O=C(O)CCCS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
CHEMBL2171027 89021 0 None -1 2 Human 7.1 pKi = 7.1 Binding
Binding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assayBinding affinity to human CCR3 receptor expressed in CHOK1 cells by radioligand displacement assay
ChEMBL 582 9 1 6 4.8 O=C(O)CCCS(=O)(=O)c1cccc(C(=O)N2CCC(N3CCC(Oc4ccc(Cl)c(Cl)c4)CC3)CC2)c1 10.1016/j.bmcl.2012.08.124
71461541 90995 0 None 15 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 513 9 3 6 2.7 CS(=O)(=O)c1ccccc1C(=O)NCC(O)CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2012.09.113
CHEMBL2208437 90995 0 None 15 2 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 513 9 3 6 2.7 CS(=O)(=O)c1ccccc1C(=O)NCC(O)CNC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1 10.1016/j.bmcl.2012.09.113
44391240 130436 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 432 2 0 2 6.7 Fc1ccc(C2C/C(=C\c3ccccc3Br)C3=Nc4ccccc4CN32)cc1 10.1016/j.bmcl.2004.11.039
CHEMBL362032 130436 0 None - 1 Human 5.1 pKi = 5.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 432 2 0 2 6.7 Fc1ccc(C2C/C(=C\c3ccccc3Br)C3=Nc4ccccc4CN32)cc1 10.1016/j.bmcl.2004.11.039
44389732 71122 0 None - 1 Human 6.1 pKi = 6.1 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 420 6 0 3 4.5 COc1ccc(CC2CCN(C3CCN(C(=O)Cc4ccccc4C)CC3)CC2)cc1 10.1016/j.bmcl.2005.01.016
CHEMBL181230 71122 0 None - 1 Human 6.1 pKi = 6.1 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 420 6 0 3 4.5 COc1ccc(CC2CCN(C3CCN(C(=O)Cc4ccccc4C)CC3)CC2)cc1 10.1016/j.bmcl.2005.01.016
71450777 90978 0 None -63 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 404 7 0 4 5.2 N#Cc1cccc(OCCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
CHEMBL2208420 90978 0 None -63 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]-4-(2,4-dichloro-3-methylphenoxy)-l'-[4- (methylsulfonyl)benzoyl]-l,4'-bipiperidine from human recombinant CCR3 expressed in CHOK1 cells after 2 hrs by scintillation counting analysis
ChEMBL 404 7 0 4 5.2 N#Cc1cccc(OCCCN2CCC(Oc3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/j.bmcl.2012.09.113
56965994 136066 0 None - 1 Human 8.1 pKi = 8.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 525 7 1 5 3.9 CCc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
CHEMBL3670813 136066 0 None - 1 Human 8.1 pKi = 8.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 525 7 1 5 3.9 CCc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C)c3)CC2)n1 nan
56965996 136051 0 None - 1 Human 8.1 pKi = 8.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 497 6 1 5 3.3 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)ccn3)CC2)ccc1Cl nan
CHEMBL3670797 136051 0 None - 1 Human 8.1 pKi = 8.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 497 6 1 5 3.3 Cc1cc(CN2CCC(N3C(=O)CC[C@@H]3C(=O)Nc3cc(C(=O)N(C)C)ccn3)CC2)ccc1Cl nan
25056324 133723 0 None - 1 Human 7.1 pKi = 7.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 459 8 1 3 5.8 Clc1cc(Cl)cc(CCNCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)c1 10.1021/jm040827u
CHEMBL365551 133723 0 None - 1 Human 7.1 pKi = 7.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 459 8 1 3 5.8 Clc1cc(Cl)cc(CCNCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)c1 10.1021/jm040827u
44401070 75886 0 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 414 6 2 3 4.7 Cc1ccc(NC(=O)NCC(c2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
CHEMBL192385 75886 0 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 414 6 2 3 4.7 Cc1ccc(NC(=O)NCC(c2ccccc2)N2CCN(c3ccccc3)CC2)cc1 10.1021/jm040827u
24937092 122815 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 500 10 0 5 6.4 CCOC(=O)Cn1c(CC)c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc21 10.1016/j.bmcl.2014.11.063
CHEMBL3355957 122815 0 None 2 2 Human 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 500 10 0 5 6.4 CCOC(=O)Cn1c(CC)c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc21 10.1016/j.bmcl.2014.11.063
44391282 129399 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 352 1 1 4 3.6 N=c1c2cccnc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL360308 129399 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 352 1 1 4 3.6 N=c1c2cccnc2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
136216709 85741 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 341 1 2 4 2.9 N=c1c2nc[nH]c2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
CHEMBL2113024 85741 0 None - 1 Human 6.1 pKi = 6.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 341 1 2 4 2.9 N=c1c2nc[nH]c2nc2n1CC/C2=C\c1ccccc1Br 10.1016/j.bmcl.2004.11.039
44387847 67269 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.8 COc1ccc(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL175547 67269 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.8 COc1ccc(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44387853 70219 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 515 8 1 3 6.8 CC(C)(C)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL179752 70219 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 515 8 1 3 6.8 CC(C)(C)c1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
57718829 122808 0 None -2 2 Mouse 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 428 7 0 3 6.4 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1C 10.1016/j.bmcl.2014.11.063
CHEMBL3355950 122808 0 None -2 2 Mouse 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 428 7 0 3 6.4 CCc1c(C2CCN(CCCSc3ccc(F)cc3)CC2)c2ccc(F)cc2n1C 10.1016/j.bmcl.2014.11.063
118721196 122804 0 None 4 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355946 122804 0 None 4 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 412 7 2 3 5.9 CCc1[nH]c2cc(O)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44389790 71546 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3cnnc4ccccc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
CHEMBL181929 71546 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 512 5 0 5 5.1 CO[C@@H]1CN(C2CCN(C(=O)c3cnnc4ccccc34)CC2)CC[C@@H]1Cc1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2005.01.016
56967063 136072 0 None - 1 Human 7.1 pKi = 7.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 565 6 1 5 4.4 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C(F)(F)F)c3)CC2)n1 nan
CHEMBL3670819 136072 0 None - 1 Human 7.1 pKi = 7.1 Binding
Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.Scintillation Proximity Assay: The CCR3 receptor binding assay was performed in a Scintillation Proximity Assay (SPA) design with the radioligand recombinant human 125Iodine-eotaxin-1. Cell membranes of hCCR3 C1 cells were again homogenized by passing through a single use needle (Terumo, 23Gx1'') and diluted in SPA incubation buffer in suitable concentrations (0.5-10 ug protein/well) in 96 well microtiter plates (1450-514, Perkin Elmer). The SPA assay was set up in the SPA incubation buffer with a final volume of 200 ul and final concentration of 25 mM HEPES, 25 mM MgCl2 6H2O, 1 mM CaCl2 2H2O and 0.1% bovine serum albumin. The SPA assay mixture contained 60 ul of the membrane suspension, 80 ul of Wheat Germ Agglutinin coated PVT beads (organic scintillator, GE Healthcare, RPNQ-0001) 0.2 mg/well), 40 ul of recombinant human 125Jodine-eotaxin-1 (Biotrend), diluted in SPA buffer to a final concentration of 30.000 dpm per well.
ChEMBL 565 6 1 5 4.4 Cc1cc(C(=O)N(C)C)cc(NC(=O)[C@H]2CCC(=O)N2C2CCN(Cc3ccc(Cl)c(C(F)(F)F)c3)CC2)n1 nan
118721184 122791 0 None -14 3 Rat 6.1 pKi = 6.1 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccccc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355933 122791 0 None -14 3 Rat 6.1 pKi = 6.1 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 396 7 1 2 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccccc2)CC1 10.1016/j.bmcl.2014.11.063
44400974 142068 0 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 485 8 1 4 5.2 COc1ccccc1CC(=O)NCC(c1ccc(C(C)(C)C)cc1)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
CHEMBL372725 142068 0 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 485 8 1 4 5.2 COc1ccccc1CC(=O)NCC(c1ccc(C(C)(C)C)cc1)N1CCN(c2ccccc2)CC1 10.1021/jm040827u
44400949 75931 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 477 8 1 3 5.7 Fc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL192412 75931 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 477 8 1 3 5.7 Fc1ccc(CCNCC(c2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401155 76948 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.8 COc1ccccc1C(CNC(=O)Nc1cc(Cl)cc(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
CHEMBL194044 76948 0 None - 1 Human 6.1 pKi = 6.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 504 7 2 4 5.8 COc1ccccc1C(CNC(=O)Nc1cc(Cl)cc(Cl)c1)N1CCN(C2CCCCC2)CC1 10.1021/jm040827u
44401094 77904 0 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 391 7 1 3 3.8 CN1CCN(C(CNCCc2ccc(C(F)(F)F)cc2)c2ccccc2)CC1 10.1021/jm040827u
CHEMBL195488 77904 0 None - 1 Human 5.1 pKi = 5.1 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 391 7 1 3 3.8 CN1CCN(C(CNCCc2ccc(C(F)(F)F)cc2)c2ccccc2)CC1 10.1021/jm040827u
11397231 88238 0 None - 1 Human 8.1 pKi = 8.1 Binding
Inhibition of CCR3 receptorInhibition of CCR3 receptor
ChEMBL 469 7 0 4 6.2 Fc1ccc(SCCCN2CCC(n3c(CC(F)(F)F)nc4cc(F)ccc43)CC2)cc1 10.1016/j.bmc.2012.09.013
CHEMBL2159766 88238 0 None - 1 Human 8.1 pKi = 8.1 Binding
Inhibition of CCR3 receptorInhibition of CCR3 receptor
ChEMBL 469 7 0 4 6.2 Fc1ccc(SCCCN2CCC(n3c(CC(F)(F)F)nc4cc(F)ccc43)CC2)cc1 10.1016/j.bmc.2012.09.013
9797962 72448 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 338 1 0 2 4.8 Brc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
CHEMBL183429 72448 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 338 1 0 2 4.8 Brc1ccccc1/C=C1\CCN2Cc3ccccc3N=C12 10.1016/j.bmcl.2004.11.039
44401032 76903 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 492 7 2 4 5.8 COc1ccc(C(CNC(=O)Nc2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL194022 76903 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 492 7 2 4 5.8 COc1ccc(C(CNC(=O)Nc2ccc(C(C)(C)C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401234 76616 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 435 9 1 4 4.8 COc1ccc(C(CNCCc2ccc(C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL193809 76616 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 435 9 1 4 4.8 COc1ccc(C(CNCCc2ccc(C)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
118721193 122801 0 None -1 3 Mouse 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 398 7 2 3 5.2 OCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355943 122801 0 None -1 3 Mouse 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from mouse CCR3 transfected in CHO cells
ChEMBL 398 7 2 3 5.2 OCc1[nH]c2ccccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
44401089 130837 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.5 COc1ccc(C(CNCCc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL363181 130837 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 489 9 1 4 5.5 COc1ccc(C(CNCCc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44391268 70673 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 312 1 0 2 4.8 Fc1ccc(/C=C2\CCN3Cc4ccccc4N=C23)c(Cl)c1 10.1016/j.bmcl.2004.11.039
CHEMBL180493 70673 0 None - 1 Human 6.0 pKi = 6.0 Binding
Binding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membraneBinding affinity measured for human C-C chemokine receptor type 3 expressed on human K562 cell membrane
ChEMBL 312 1 0 2 4.8 Fc1ccc(/C=C2\CCN3Cc4ccccc4N=C23)c(Cl)c1 10.1016/j.bmcl.2004.11.039
44387857 67808 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 542 6 2 3 6.8 O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1cc(Cl)cc(Cl)c1 10.1021/jm040827u
CHEMBL176281 67808 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 542 6 2 3 6.8 O=C(NCC(c1ccc(C(F)(F)F)cc1)N1CCN(C2CCCCC2)CC1)Nc1cc(Cl)cc(Cl)c1 10.1021/jm040827u
44389729 71123 0 None - 1 Human 6.0 pKi = 6.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(Cl)cc(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
CHEMBL181232 71123 0 None - 1 Human 6.0 pKi = 6.0 Binding
In vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell lineIn vitro binding affinity against C-C chemokine receptor type 3 expressing in rat Y3 cell line
ChEMBL 458 5 0 2 5.8 Cc1ccccc1CC(=O)N1CCC(N2CCC(Cc3cc(Cl)cc(Cl)c3)CC2)CC1 10.1016/j.bmcl.2005.01.016
118721187 122794 0 None -10 3 Rat 6.0 pKi = 6.0 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(OC)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355936 122794 0 None -10 3 Rat 6.0 pKi = 6.0 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(OC)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721187 122794 0 None 1 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(OC)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355936 122794 0 None 1 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 426 8 1 3 6.2 CCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(OC)cc2)CC1 10.1016/j.bmcl.2014.11.063
44400978 142654 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 530 6 2 3 6.8 CC(C)(C)c1ccc(C(CNC(=O)Nc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL373092 142654 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 530 6 2 3 6.8 CC(C)(C)c1ccc(C(CNC(=O)Nc2ccc(C(F)(F)F)cc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
118721203 122821 0 None 1 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccnc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355963 122821 0 None 1 3 Human 7.0 pKi = 7.0 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccnc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)c1 10.1016/j.bmcl.2014.11.063
44400983 77913 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 436 7 2 4 4.5 COc1ccc(NC(=O)NCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL195533 77913 0 None - 1 Human 5.0 pKi = 5.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 436 7 2 4 4.5 COc1ccc(NC(=O)NCC(c2ccccc2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
44401176 75176 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 517 7 2 4 5.9 CN(C)c1ccc(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
CHEMBL191696 75176 0 None - 1 Human 6.0 pKi = 6.0 Binding
Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)Inhibition of [125I]eotaxin-1 binding to human chemokine receptor (hCCR3-C1)
ChEMBL 517 7 2 4 5.9 CN(C)c1ccc(C(CNC(=O)Nc2cc(Cl)cc(Cl)c2)N2CCN(C3CCCCC3)CC2)cc1 10.1021/jm040827u
118721190 122797 0 None -5 3 Human 7.0 pKi = 7 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 416 7 2 3 5.3 OCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
CHEMBL3355939 122797 0 None -5 3 Human 7.0 pKi = 7 Binding
Displacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cellsDisplacement of [125J]-eotaxin-1 from human CCR3 transfected in human K562 cells
ChEMBL 416 7 2 3 5.3 OCc1[nH]c2cc(F)ccc2c1C1CCN(CCCSc2ccc(F)cc2)CC1 10.1016/j.bmcl.2014.11.063
118721203 122821 0 None -10 3 Rat 6.0 pKi = 6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccnc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)c1 10.1016/j.bmcl.2014.11.063
CHEMBL3355963 122821 0 None -10 3 Rat 6.0 pKi = 6 Binding
Displacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cellsDisplacement of [125J]-eotaxin-1 from rat CCR3 transfected in CHO cells
ChEMBL 563 10 0 6 7.4 CCOC(=O)c1ccnc(-n2c(CC)c(C3CCN(CCCSc4ccc(F)cc4)CC3)c3ccc(F)cc32)c1 10.1016/j.bmcl.2014.11.063
795 7362 5 None - 1 Human 8.3 pKd None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 12450563
796 7362 5 None - 1 Human 8.3 pKd None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 12450563
9913085 7362 5 None - 1 Human 8.3 pKd None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 12450563
CHEMBL20921 7362 5 None - 1 Human 8.3 pKd None 8.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 12450563
11753159 7335 6 None 1 2 Human 8.2 pKi = 8.2 Binding
Assay using sodium salt of the compoundAssay using sodium salt of the compound
Guide to Pharmacology 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 23031591
7679 7335 6 None 1 2 Human 8.2 pKi = 8.2 Binding
Assay using sodium salt of the compoundAssay using sodium salt of the compound
Guide to Pharmacology 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 23031591
CHEMBL2158814 7335 6 None 1 2 Human 8.2 pKi = 8.2 Binding
Assay using sodium salt of the compoundAssay using sodium salt of the compound
Guide to Pharmacology 525 5 1 5 4.7 Cc1ccc(cc1)S(=O)(=O)NC(=O)N1CCC(CC1)N1CCC(CC1)Oc1ccc(c(c1)Cl)Cl 23031591
10653 9068 12 None - 1 Human 8.5 pKi = 8.5 Binding
Dissociation constant determined in a scintillation proximity binding assay using recombinant human [<sup>125</sup>]l-eotaxin-1 as radioligand and cell membranes prepared from K562 cells transfected with hCCR3.Dissociation constant determined in a scintillation proximity binding assay using recombinant human [<sup>125</sup>]l-eotaxin-1 as radioligand and cell membranes prepared from K562 cells transfected with hCCR3.
Guide to Pharmacology 511 6 1 5 3.6 O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C None
59534386 9068 12 None - 1 Human 8.5 pKi = 8.5 Binding
Dissociation constant determined in a scintillation proximity binding assay using recombinant human [<sup>125</sup>]l-eotaxin-1 as radioligand and cell membranes prepared from K562 cells transfected with hCCR3.Dissociation constant determined in a scintillation proximity binding assay using recombinant human [<sup>125</sup>]l-eotaxin-1 as radioligand and cell membranes prepared from K562 cells transfected with hCCR3.
Guide to Pharmacology 511 6 1 5 3.6 O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C None
CHEMBL3670800 9068 12 None - 1 Human 8.5 pKi = 8.5 Binding
Dissociation constant determined in a scintillation proximity binding assay using recombinant human [<sup>125</sup>]l-eotaxin-1 as radioligand and cell membranes prepared from K562 cells transfected with hCCR3.Dissociation constant determined in a scintillation proximity binding assay using recombinant human [<sup>125</sup>]l-eotaxin-1 as radioligand and cell membranes prepared from K562 cells transfected with hCCR3.
Guide to Pharmacology 511 6 1 5 3.6 O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C None
DB15269 9068 12 None - 1 Human 8.5 pKi = 8.5 Binding
Dissociation constant determined in a scintillation proximity binding assay using recombinant human [<sup>125</sup>]l-eotaxin-1 as radioligand and cell membranes prepared from K562 cells transfected with hCCR3.Dissociation constant determined in a scintillation proximity binding assay using recombinant human [<sup>125</sup>]l-eotaxin-1 as radioligand and cell membranes prepared from K562 cells transfected with hCCR3.
Guide to Pharmacology 511 6 1 5 3.6 O=C([C@H]1CCC(=O)N1C1CCN(CC1)Cc1ccc(c(c1)C)Cl)Nc1nc(C)cc(c1)C(=O)N(C)C None
3492 7479 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 12067561
9868459 7479 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 12067561
CHEMBL50593 7479 0 None - 1 Human 8.1 pKi = 8.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 451 10 3 4 4.5 CC[C@@H]([C@H]1C[C@H](CCN1CCCNC(=O)Nc1cccc(c1)C(=O)C)Cc1ccccc1)O 12067561
3530 10291 0 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 378 6 1 5 3.3 COC(=O)[C@@H](NC(=O)c1ccc2c(c1)cccc2)Cc1ccc(cc1)N(=O)=O None
5311092 10291 0 None - 1 Human 8.4 pKi = 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 378 6 1 5 3.3 COC(=O)[C@@H](NC(=O)c1ccc2c(c1)cccc2)Cc1ccc(cc1)N(=O)=O None
795 7362 5 None - 1 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 12450563
796 7362 5 None - 1 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 12450563
9913085 7362 5 None - 1 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 12450563
CHEMBL20921 7362 5 None - 1 Human 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N 12450563
758 7651 0 None -3 4 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8642344
759 7654 0 None 6 4 Human 8.9 pKi = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8642344
787 7614 0 None - 1 Human 9.8 pKi = 9.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8642344
769 7613 0 None 446 2 Human 9.9 pKi = 9.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8642344
771 7625 0 None 1 2 Human 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8642344