Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
156013177 177457 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 559 7 1 7 5.4 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Br)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4638895 177457 0 None - 1 Human 6.0 pIC50 = 6 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 559 7 1 7 5.4 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Br)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156011084 177095 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4633217 177095 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156021011 178051 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4647206 178051 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
71768224 177966 21 None 39 2 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4645971 177966 21 None 39 2 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156015010 177550 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4640319 177550 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012910 177446 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4638791 177446 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156019927 177949 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 441 6 2 4 4.1 COc1cccc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)c1 10.1016/j.bmcl.2019.126899
CHEMBL4645725 177949 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 441 6 2 4 4.1 COc1cccc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)c1 10.1016/j.bmcl.2019.126899
156019169 178007 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 10.1016/j.bmcl.2019.126899
CHEMBL4646463 178007 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 10.1016/j.bmcl.2019.126899
156016038 177627 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cccc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4641144 177627 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cccc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156013415 177473 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 495 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(C)ccc2C)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4639114 177473 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 495 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(C)ccc2C)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156020735 178116 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4648121 178116 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156021922 178191 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)c(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4649351 178191 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)c(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156010556 177034 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 499 7 1 7 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4632425 177034 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 499 7 1 7 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156010734 177088 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 480 7 1 6 5.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4633183 177088 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 480 7 1 6 5.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
25303824 178125 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 467 8 2 6 3.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4648327 178125 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 467 8 2 6 3.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156016810 177751 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(F)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4642662 177751 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(F)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156016430 177672 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4641681 177672 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156019204 177954 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 545 8 2 6 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Br)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4645763 177954 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 545 8 2 6 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Br)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156018695 177868 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4644405 177868 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156016371 177640 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 475 7 1 6 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3n2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4641301 177640 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 475 7 1 6 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3n2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
25303824 177396 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 467 8 2 6 3.5 COc1cc(C(=O)N[C@@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4638193 177396 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 467 8 2 6 3.5 COc1cc(C(=O)N[C@@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156020287 178085 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4647701 178085 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156014652 177234 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4635707 177234 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012554 177346 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 474 7 1 5 5.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4637473 177346 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 474 7 1 5 5.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012971 177513 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 495 7 1 7 4.9 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4639692 177513 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 495 7 1 7 4.9 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012542 177324 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 549 7 1 7 5.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4637126 177324 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 549 7 1 7 5.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156014926 177547 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1cccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)c1 10.1016/j.bmcl.2019.126899
CHEMBL4640301 177547 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1cccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)c1 10.1016/j.bmcl.2019.126899
156017591 177842 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 455 5 2 5 3.8 O=C(CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1ccc3c(c1)OCO3)C2)Nc1ccc(Cl)cc1 10.1016/j.bmcl.2019.126899
CHEMBL4644085 177842 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 455 5 2 5 3.8 O=C(CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1ccc3c(c1)OCO3)C2)Nc1ccc(Cl)cc1 10.1016/j.bmcl.2019.126899
156019124 177930 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 441 6 2 4 4.1 COc1ccc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2019.126899
CHEMBL4645432 177930 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 441 6 2 4 4.1 COc1ccc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2019.126899
156018089 177849 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2F)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4644133 177849 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2F)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156018738 177926 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 539 10 2 8 3.6 CCOC(=O)c1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 10.1016/j.bmcl.2019.126899
CHEMBL4645361 177926 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 539 10 2 8 3.6 CCOC(=O)c1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 10.1016/j.bmcl.2019.126899
156019654 178013 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)ccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4646569 178013 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)ccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156010068 177071 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 492 8 2 7 3.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C#N)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4632989 177071 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 492 8 2 7 3.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C#N)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156015077 177527 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C(F)(F)F)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4639996 177527 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C(F)(F)F)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156017102 177712 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 481 7 1 7 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4642230 177712 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 481 7 1 7 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156015991 177532 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(F)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4640101 177532 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(F)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012383 177417 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cccc(Cl)c3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4638493 177417 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cccc(Cl)c3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156015439 177556 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 545 8 2 6 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Br)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4640388 177556 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 545 8 2 6 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Br)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156019227 177984 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Cl)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4646120 177984 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Cl)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156020329 178157 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4648997 178157 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156014947 177588 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4640657 177588 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of forskolin-induced cAMP accumulation by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C)cc(OC)c1OC 10.1016/j.bmcl.2019.126899


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
Sel. page Similar-
ity		 Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Assay
Type		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
71525976 153489 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at CXCR6 (unknown origin)Antagonist activity at CXCR6 (unknown origin)
ChEMBL 453 7 3 8 3.1 Cc1ccc(C(Nc2c(Nc3cccc(C(=O)N(C)C)c3O)c(=O)c2=O)C2(C)CCCO2)o1 10.1021/acs.jmedchem.5b01337
CHEMBL3979652 153489 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Antagonist activity at CXCR6 (unknown origin)Antagonist activity at CXCR6 (unknown origin)
ChEMBL 453 7 3 8 3.1 Cc1ccc(C(Nc2c(Nc3cccc(C(=O)N(C)C)c3O)c(=O)c2=O)C2(C)CCCO2)o1 10.1021/acs.jmedchem.5b01337
156019475 177979 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 464 7 2 6 3.9 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3[nH]2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4646034 177979 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 464 7 2 6 3.9 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3[nH]2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156010556 177034 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 499 7 1 7 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4632425 177034 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 499 7 1 7 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156020287 178085 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4647701 178085 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156020779 178180 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 509 8 1 8 4.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)c2nc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4649243 178180 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 509 8 1 8 4.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)c2nc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156019227 177984 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Cl)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4646120 177984 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Cl)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156019654 178013 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)ccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4646569 178013 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)ccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
71768224 177966 21 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4645971 177966 21 None - 0 Human 6.9 pIC50 = 6.9 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012910 177446 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4638791 177446 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156015439 177556 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 545 8 2 6 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Br)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4640388 177556 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 545 8 2 6 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Br)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156020329 178157 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4648997 178157 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)cc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156018738 177926 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 539 10 2 8 3.6 CCOC(=O)c1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 10.1016/j.bmcl.2019.126899
CHEMBL4645361 177926 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 539 10 2 8 3.6 CCOC(=O)c1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 10.1016/j.bmcl.2019.126899
156016430 177672 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4641681 177672 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cc(Cl)ccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156020735 178116 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4648121 178116 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(C)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
71768224 177966 21 None - 0 Mouse 4.8 pIC50 = 4.8 Binding
Antagonist activity at mouse CXCR6 by DiscoveRx cell based beta-arrestin assayAntagonist activity at mouse CXCR6 by DiscoveRx cell based beta-arrestin assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4645971 177966 21 None - 0 Mouse 4.8 pIC50 = 4.8 Binding
Antagonist activity at mouse CXCR6 by DiscoveRx cell based beta-arrestin assayAntagonist activity at mouse CXCR6 by DiscoveRx cell based beta-arrestin assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
71768225 177863 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1ccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)cc1 10.1016/j.bmcl.2019.126899
CHEMBL4644339 177863 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1ccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)cc1 10.1016/j.bmcl.2019.126899
156019169 178007 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 10.1016/j.bmcl.2019.126899
CHEMBL4646463 178007 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1ccccc1NC(=O)CN1[C@H]2CCC[C@@H]1C[C@@H](NC(=O)c1cc(OC)c(OC)c(OC)c1)C2 10.1016/j.bmcl.2019.126899
156012542 177324 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of CXCR6-mediated cell invasion in human SKHEP1 cells after 72 hrs by transwell assayInhibition of CXCR6-mediated cell invasion in human SKHEP1 cells after 72 hrs by transwell assay
ChEMBL 549 7 1 7 5.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4637126 177324 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of CXCR6-mediated cell invasion in human SKHEP1 cells after 72 hrs by transwell assayInhibition of CXCR6-mediated cell invasion in human SKHEP1 cells after 72 hrs by transwell assay
ChEMBL 549 7 1 7 5.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156014218 177243 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 463 7 2 5 4.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3[nH]2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4635792 177243 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 463 7 2 5 4.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3[nH]2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156018695 177868 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4644405 177868 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc(Cl)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012971 177513 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 495 7 1 7 4.9 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4639692 177513 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 495 7 1 7 4.9 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012383 177417 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cccc(Cl)c3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4638493 177417 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3cccc(Cl)c3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156015010 177550 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4640319 177550 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 515 7 1 7 5.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccc(Cl)cc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156017102 177712 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 481 7 1 7 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4642230 177712 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 481 7 1 7 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156021011 178051 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4647206 178051 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(Cl)cc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156013810 177283 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 511 8 1 8 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(OC)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4636339 177283 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 511 8 1 8 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(OC)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012554 177346 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 474 7 1 5 5.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4637473 177346 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 474 7 1 5 5.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156019204 177954 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 545 8 2 6 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Br)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4645763 177954 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 545 8 2 6 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Br)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156021922 178191 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)c(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4649351 178191 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(Cl)c(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156013800 177278 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2c(Cl)cccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4636310 177278 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2c(Cl)cccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012542 177324 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 549 7 1 7 5.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4637126 177324 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 549 7 1 7 5.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156012542 177324 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 549 7 1 7 5.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4637126 177324 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 549 7 1 7 5.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(C(F)(F)F)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156014652 177234 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4635707 177234 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 501 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156014926 177547 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1cccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)c1 10.1016/j.bmcl.2019.126899
CHEMBL4640301 177547 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 497 9 2 7 3.5 COc1cccc(NC(=O)CN2[C@H]3CCC[C@@H]2C[C@@H](NC(=O)c2cc(OC)c(OC)c(OC)c2)C3)c1 10.1016/j.bmcl.2019.126899
156016810 177751 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(F)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4642662 177751 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(F)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
25303824 178125 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 467 8 2 6 3.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4648327 178125 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 467 8 2 6 3.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156013415 177473 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 495 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(C)ccc2C)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4639114 177473 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 495 8 2 6 4.1 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cc(C)ccc2C)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156018089 177849 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2F)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4644133 177849 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2F)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156015077 177527 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C(F)(F)F)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4639996 177527 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 535 8 2 6 4.5 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C(F)(F)F)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156016371 177640 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 475 7 1 6 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3n2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4641301 177640 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 475 7 1 6 4.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccc3ccccc3n2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156011084 177095 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4633217 177095 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2ccccc2Cl)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156016540 177737 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 465 7 1 7 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3o2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4642449 177737 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 465 7 1 7 4.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3ccccc3o2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156014947 177588 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4640657 177588 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156013177 177457 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 559 7 1 7 5.4 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Br)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4638895 177457 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 559 7 1 7 5.4 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2nc3c(Br)cccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156015991 177532 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(F)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4640101 177532 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 485 8 2 6 3.6 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2cccc(F)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156010734 177088 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 480 7 1 6 5.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4633183 177088 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 480 7 1 6 5.2 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cc3ccccc3s2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156010068 177071 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 492 8 2 7 3.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C#N)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4632989 177071 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 492 8 2 7 3.3 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccccc2C#N)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156016038 177627 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cccc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4641144 177627 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 458 7 1 5 4.7 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3Cc2cccc(Cl)c2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
156021218 178142 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(C)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
CHEMBL4648749 178142 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Antagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assayAntagonist activity at Prolink-tagged human CXCR6 receptor assessed as inhibition of CXCL16-induced beta-arrestin recruitment by DiscoveRx cell based assay
ChEMBL 481 8 2 6 3.8 COc1cc(C(=O)N[C@H]2C[C@@H]3CCC[C@H](C2)N3CC(=O)Nc2ccc(C)cc2)cc(OC)c1OC 10.1016/j.bmcl.2019.126899
855 1252 0 None - 1 Human 9.0 pKd = 9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11290797