Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
10099401 107986 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 562 15 1 3 6.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL295895 107986 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 562 15 1 3 6.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
10120470 182239 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 563 14 2 4 3.8 CCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL45770 182239 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 563 14 2 4 3.8 CCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
44293169 189932 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 551 14 0 5 5.5 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL47953 189932 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 551 14 0 5 5.5 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293020 187010 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 482 11 0 5 4.6 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL47500 187010 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 482 11 0 5 4.6 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
71224515 147209 0 None - 1 Human 7.0 pEC50 = 7 Functional
Positive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF assayPositive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 557 9 2 5 4.5 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2ccc(F)cc2)CC1 10.1021/acsmedchemlett.6b00082
CHEMBL3809148 147209 0 None - 1 Human 7.0 pEC50 = 7 Functional
Positive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF assayPositive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 557 9 2 5 4.5 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2ccc(F)cc2)CC1 10.1021/acsmedchemlett.6b00082
44293287 194110 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL49308 194110 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@H]1C 10.1016/j.bmcl.2004.01.043
44293019 169446 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 464 11 0 3 5.6 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(C)c(OC)c(C)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL417003 169446 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 464 11 0 3 5.6 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(C)c(OC)c(C)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
53322111 64140 0 None -125 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 482 7 4 8 3.4 C#CCNC(=O)CNc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1 10.1021/ml100229v
CHEMBL1651721 64140 0 None -125 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 482 7 4 8 3.4 C#CCNC(=O)CNc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1 10.1021/ml100229v
10164519 194628 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL49624 194628 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292938 185744 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 547 15 0 3 6.5 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL47059 185744 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 547 15 0 3 6.5 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292917 178451 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 519 13 0 3 5.7 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL44663 178451 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 519 13 0 3 5.7 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292891 194504 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL49540 194504 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@H]1C 10.1016/j.bmcl.2004.01.043
10030777 174964 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 563 15 0 4 6.7 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL433263 174964 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 563 15 0 4 6.7 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293324 108370 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 482 12 0 5 4.6 CCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL298686 108370 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 482 12 0 5 4.6 CCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
44293289 105739 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 496 12 0 5 5.0 CCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL279759 105739 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 496 12 0 5 5.0 CCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292945 169541 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 563 15 2 4 4.8 CCCCCCNC(=O)CN1C(=O)C(Cc2ccc(-c3ccc(CN(CCCC)C(=O)NC)cc3)cc2)N(C)C1=O 10.1016/j.bmcl.2004.01.042
CHEMBL417173 169541 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 563 15 2 4 4.8 CCCCCCNC(=O)CN1C(=O)C(Cc2ccc(-c3ccc(CN(CCCC)C(=O)NC)cc3)cc2)N(C)C1=O 10.1016/j.bmcl.2004.01.042
10461880 195549 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 645 13 3 4 5.4 CCCCN(Cc1cccc(-c2ccc(C(=O)NC3CCCCN(CC(=O)NCCc4ccc(Cl)cc4)C3=O)cc2)c1)C(=O)NC 10.1016/j.bmcl.2004.01.042
CHEMBL50556 195549 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 645 13 3 4 5.4 CCCCN(Cc1cccc(-c2ccc(C(=O)NC3CCCCN(CC(=O)NCCc4ccc(Cl)cc4)C3=O)cc2)c1)C(=O)NC 10.1016/j.bmcl.2004.01.042
71234037 117916 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 531 9 2 7 3.7 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCOC3=O)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263689 117916 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 531 9 2 7 3.7 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCOC3=O)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
10142987 108561 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 525 13 1 6 3.3 CCCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL300022 108561 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 525 13 1 6 3.3 CCCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
44292731 190459 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 550 14 1 4 5.1 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL48030 190459 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 550 14 1 4 5.1 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292995 195236 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 468 11 0 5 4.2 CCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL50278 195236 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 468 11 0 5 4.2 CCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
71233908 117913 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 515 8 2 6 3.5 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCN3CCCC3=O)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263683 117913 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 515 8 2 6 3.5 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCN3CCCC3=O)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
10030777 174964 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 563 15 0 4 6.7 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL433263 174964 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 563 15 0 4 6.7 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
10164519 194628 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL49624 194628 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293289 105739 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFollicle stimulating hormone receptor cell-based cAMP accumulation assayAgonistic activity in CHO-hFollicle stimulating hormone receptor cell-based cAMP accumulation assay
ChEMBL 496 12 0 5 5.0 CCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL279759 105739 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFollicle stimulating hormone receptor cell-based cAMP accumulation assayAgonistic activity in CHO-hFollicle stimulating hormone receptor cell-based cAMP accumulation assay
ChEMBL 496 12 0 5 5.0 CCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293018 186358 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 466 12 0 4 4.9 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3ccc(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL47420 186358 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 466 12 0 4 4.9 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3ccc(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
44292938 185744 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 547 15 0 3 6.5 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL47059 185744 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 547 15 0 3 6.5 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
10165009 185800 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 521 15 1 4 5.8 CCCCOC(=O)N(CC(=O)NCC1CC1)Cc1ccc(-c2ccccc2CN(CCCC)C(C)=O)cc1 10.1016/j.bmcl.2004.01.042
CHEMBL47120 185800 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 521 15 1 4 5.8 CCCCOC(=O)N(CC(=O)NCC1CC1)Cc1ccc(-c2ccccc2CN(CCCC)C(C)=O)cc1 10.1016/j.bmcl.2004.01.042
44255904 64158 0 None -79 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 682 17 4 14 3.9 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCN=[N+]=[N-])nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651828 64158 0 None -79 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 682 17 4 14 3.9 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCN=[N+]=[N-])nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
10185204 183373 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 496 13 0 5 5.0 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL45976 183373 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 496 13 0 5 5.0 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
2837084 77914 16 None - 1 Human 5.4 pEC50 = 5.4 Functional
Effective concentration for maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorEffective concentration for maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 308 1 1 2 4.1 CC(=O)N1c2ccc(N)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL195534 77914 16 None - 1 Human 5.4 pEC50 = 5.4 Functional
Effective concentration for maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorEffective concentration for maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 308 1 1 2 4.1 CC(=O)N1c2ccc(N)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
71234065 117914 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 537 8 3 6 4.2 Cc1ccccc1N1CCN(c2ccc(C(=O)NCc3cccc(C(N)=O)c3)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263685 117914 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 537 8 3 6 4.2 Cc1ccccc1N1CCN(c2ccc(C(=O)NCc3cccc(C(N)=O)c3)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
44293203 191037 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 535 13 0 4 5.9 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL48375 191037 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 535 13 0 4 5.9 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
71450781 91113 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human FSH receptor by aromatase-based assayAgonist activity at human FSH receptor by aromatase-based assay
ChEMBL 514 9 2 5 4.5 CCOc1cc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)NC2=O)ccc1OC 10.1016/j.bmc.2012.03.069
CHEMBL2216804 91113 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human FSH receptor by aromatase-based assayAgonist activity at human FSH receptor by aromatase-based assay
ChEMBL 514 9 2 5 4.5 CCOc1cc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)NC2=O)ccc1OC 10.1016/j.bmc.2012.03.069
44580873 200101 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human recombinant FSH receptorAgonist activity at human recombinant FSH receptor
ChEMBL 561 9 2 5 5.1 COc1ccc(C2SC(CC(=O)NCCC3=CCc4ccccc43)C(=O)N2c2ccc(C(N)=O)c(Cl)c2)cc1 10.1016/j.ejmech.2007.07.017
CHEMBL524348 200101 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human recombinant FSH receptorAgonist activity at human recombinant FSH receptor
ChEMBL 561 9 2 5 5.1 COc1ccc(C2SC(CC(=O)NCCC3=CCc4ccccc43)C(=O)N2c2ccc(C(N)=O)c(Cl)c2)cc1 10.1016/j.ejmech.2007.07.017
44293299 182303 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 466 12 0 4 4.9 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)cc(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL45782 182303 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 466 12 0 4 4.9 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)cc(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
71224679 117918 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 559 7 4 8 3.4 Cc1ccccc1N1CCN(c2ccc(C(=O)N[C@@H]3CCC[C@@H](O)[C@H]3O)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263692 117918 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 559 7 4 8 3.4 Cc1ccccc1N1CCN(c2ccc(C(=O)N[C@@H]3CCC[C@@H](O)[C@H]3O)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1016/j.bmcl.2014.03.018
44293203 191037 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 535 13 0 4 5.9 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL48375 191037 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 535 13 0 4 5.9 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292920 108068 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL296449 108068 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293189 194607 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 534 13 1 3 5.5 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL49608 194607 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 534 13 1 3 5.5 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
10099401 107986 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 562 15 1 3 6.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL295895 107986 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 562 15 1 3 6.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293203 191037 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 535 13 0 4 5.9 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL48375 191037 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 535 13 0 4 5.9 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
71450781 91113 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human FSH receptor by cAMP-based assayAgonist activity at human FSH receptor by cAMP-based assay
ChEMBL 514 9 2 5 4.5 CCOc1cc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)NC2=O)ccc1OC 10.1016/j.bmc.2012.03.069
CHEMBL2216804 91113 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human FSH receptor by cAMP-based assayAgonist activity at human FSH receptor by cAMP-based assay
ChEMBL 514 9 2 5 4.5 CCOc1cc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)NC2=O)ccc1OC 10.1016/j.bmc.2012.03.069
71234040 117915 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 516 9 2 6 4.7 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCC3CCOC3)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263687 117915 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 516 9 2 6 4.7 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCC3CCOC3)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
71234266 117917 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 555 10 3 9 3.3 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCc3nn[nH]n3)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263691 117917 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 555 10 3 9 3.3 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCc3nn[nH]n3)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1016/j.bmcl.2014.03.018
44293189 194607 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 534 13 1 3 5.5 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL49608 194607 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 534 13 1 3 5.5 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293172 183723 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 535 14 0 4 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL46216 183723 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 535 14 0 4 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292698 189046 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 14 0 5 5.3 CCCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL47838 189046 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 14 0 5 5.3 CCCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
44293300 174897 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 454 10 0 5 3.8 CCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL432883 174897 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 454 10 0 5 3.8 CCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
71233981 117912 0 None - 1 Human 4.0 pEC50 = 4 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 570 10 2 7 4.2 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263667 117912 0 None - 1 Human 4.0 pEC50 = 4 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 570 10 2 7 4.2 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1016/j.bmcl.2014.03.018
11260332 75454 0 None 51 2 Human 8.0 pIC50 = 8 Functional
In vitro inhibition of maximum response evoked by cAMP on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response evoked by cAMP on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL192135 75454 0 None 51 2 Human 8.0 pIC50 = 8 Functional
In vitro inhibition of maximum response evoked by cAMP on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response evoked by cAMP on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
53324743 64156 0 None -18 2 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 1313 30 5 21 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651826 64156 0 None -18 2 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 1313 30 5 21 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
11190706 142055 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 475 5 0 2 7.8 CC(=O)N1c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL372649 142055 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 475 5 0 2 7.8 CC(=O)N1c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
53324742 64155 0 None -26 2 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 1269 27 5 20 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651825 64155 0 None -26 2 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 1269 27 5 20 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
11352881 173031 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 518 5 1 3 7.5 COc1ccccc1C1(C)CC(C)(C)N(C(C)=O)c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc21 10.1021/jm049676l
CHEMBL426824 173031 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 518 5 1 3 7.5 COc1ccccc1C1(C)CC(C)(C)N(C(C)=O)c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc21 10.1021/jm049676l
11442786 77865 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 470 6 1 3 5.5 COc1ccc(CCNC(=O)c2ccc3c(c2)C(C)(c2ccccc2)CC(C)(C)N3C(C)=O)cc1 10.1021/jm049676l
CHEMBL195321 77865 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 470 6 1 3 5.5 COc1ccc(CCNC(=O)c2ccc3c(c2)C(C)(c2ccccc2)CC(C)(C)N3C(C)=O)cc1 10.1021/jm049676l
11156384 130834 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 504 4 2 3 7.2 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccc(O)cc2)CC1(C)C 10.1021/jm049676l
CHEMBL363164 130834 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 504 4 2 3 7.2 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccc(O)cc2)CC1(C)C 10.1021/jm049676l
11306348 77897 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL195469 77897 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11258158 129903 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 402 3 1 3 5.4 CC(=O)N1c2ccc(NC(=O)c3ccco3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL361167 129903 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 402 3 1 3 5.4 CC(=O)N1c2ccc(NC(=O)c3ccco3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11260332 75454 0 None 51 2 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL192135 75454 0 None 51 2 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11431176 140745 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 462 5 1 3 5.5 CC(=O)N1c2ccc(NS(=O)(=O)Cc3ccccc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL371595 140745 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 462 5 1 3 5.5 CC(=O)N1c2ccc(NS(=O)(=O)Cc3ccccc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11203161 76099 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 518 5 1 3 7.5 COc1cc(NC(=O)c2ccc(-c3ccccc3)cc2)cc2c1N(C(C)=O)C(C)(C)CC2(C)c1ccccc1 10.1021/jm049676l
CHEMBL192868 76099 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 518 5 1 3 7.5 COc1cc(NC(=O)c2ccc(-c3ccccc3)cc2)cc2c1N(C(C)=O)C(C)(C)CC2(C)c1ccccc1 10.1021/jm049676l
11224637 69938 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 446 3 1 2 6.4 CC(=O)N1c2ccc(NC(=O)c3ccc(Cl)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL178980 69938 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 446 3 1 2 6.4 CC(=O)N1c2ccc(NC(=O)c3ccc(Cl)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
53326035 64157 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 742 16 1 9 8.0 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2[C@@](C)(c2ccc(OCc3cn(CCOCCOCCN=[N+]=[N-])nn3)cc2)CC1(C)C 10.1021/ml100229v
CHEMBL1651827 64157 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 742 16 1 9 8.0 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2[C@@](C)(c2ccc(OCc3cn(CCOCCOCCN=[N+]=[N-])nn3)cc2)CC1(C)C 10.1021/ml100229v
53318154 64141 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 542 6 1 3 7.5 C#CCOc1ccc([C@@]2(C)CC(C)(C)N(C(C)=O)c3ccc(NC(=O)c4ccc(-c5ccccc5)cc4)cc32)cc1 10.1021/ml100229v
CHEMBL1651722 64141 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 542 6 1 3 7.5 C#CCOc1ccc([C@@]2(C)CC(C)(C)N(C(C)=O)c3ccc(NC(=O)c4ccc(-c5ccccc5)cc4)cc32)cc1 10.1021/ml100229v
11260332 75454 0 None 51 2 Human 8.4 pIC50 = 8.4 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL192135 75454 0 None 51 2 Human 8.4 pIC50 = 8.4 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11396885 129864 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 454 5 1 2 6.7 CCCc1ccc(C(=O)Nc2ccc3c(c2)C(C)(c2ccccc2)CC(C)(C)N3C(C)=O)cc1 10.1021/jm049676l
CHEMBL360981 129864 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 454 5 1 2 6.7 CCCc1ccc(C(=O)Nc2ccc3c(c2)C(C)(c2ccccc2)CC(C)(C)N3C(C)=O)cc1 10.1021/jm049676l
11283470 175453 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 502 4 1 2 7.8 CC(=O)N1c2cc(C)c(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL436481 175453 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 502 4 1 2 7.8 CC(=O)N1c2cc(C)c(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11375523 77870 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 502 4 1 2 7.8 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccc(C)cc2)CC1(C)C 10.1021/jm049676l
CHEMBL195347 77870 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 502 4 1 2 7.8 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccc(C)cc2)CC1(C)C 10.1021/jm049676l
11443213 75781 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 489 4 0 3 7.4 CC(=O)N1c2ccc(OC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL192334 75781 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 489 4 0 3 7.4 CC(=O)N1c2ccc(OC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11260332 75454 0 None -51 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro inhibition against maximum response evoked by cAMP in rat GFSHR-17 granulosa cell lineIn vitro inhibition against maximum response evoked by cAMP in rat GFSHR-17 granulosa cell line
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL192135 75454 0 None -51 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro inhibition against maximum response evoked by cAMP in rat GFSHR-17 granulosa cell lineIn vitro inhibition against maximum response evoked by cAMP in rat GFSHR-17 granulosa cell line
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11407702 142021 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 427 3 2 2 6.2 CC(=O)N1c2ccc(NC(=O)Nc3ccccc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL372506 142021 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 427 3 2 2 6.2 CC(=O)N1c2ccc(NC(=O)Nc3ccccc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11190814 130399 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 480 3 1 2 6.8 CC(=O)N1c2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL361847 130399 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 480 3 1 2 6.8 CC(=O)N1c2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11373573 70136 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 422 4 1 3 5.3 CC(=O)N1c2ccc(NC(=O)COC(C)(C)C)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL179505 70136 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 422 4 1 3 5.3 CC(=O)N1c2ccc(NC(=O)COC(C)(C)C)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11283209 133662 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3cccc(-c4ccccc4)c3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL365545 133662 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3cccc(-c4ccccc4)c3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
53320758 64154 0 None -21 2 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 1225 24 5 19 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651824 64154 0 None -21 2 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 1225 24 5 19 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
11224817 77399 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 454 4 1 2 7.4 CC(=O)N1c2ccc(NCc3ccc(C(C)(C)C)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL194996 77399 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 454 4 1 2 7.4 CC(=O)N1c2ccc(NCc3ccc(C(C)(C)C)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL2369814 216471 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00130a019
14557576 96150 0 None - 0 Rat 6.1 pKd = 6.1 Functional
Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL 961 26 12 11 -0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL2369794 96150 0 None - 0 Rat 6.1 pKd = 6.1 Functional
Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL 961 26 12 11 -0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00130a019
3172428 55183 4 None -158 2 Human 5.3 pPotency = 5.3 Functional
PUBCHEM_BIOASSAY: Counterscreen for Agonists of Thyroid Stimulating Hormone Receptor: HTRF Activity in a Follicle Stimulating Hormone Receptor Cell Line. (Class of assay: confirmatory) [Related pubchem assays: 926, 939, 933, 938, 953 ]PUBCHEM_BIOASSAY: Counterscreen for Agonists of Thyroid Stimulating Hormone Receptor: HTRF Activity in a Follicle Stimulating Hormone Receptor Cell Line. (Class of assay: confirmatory) [Related pubchem assays: 926, 939, 933, 938, 953 ]
ChEMBL 459 7 3 8 1.6 NC(=O)c1nsc(C(=O)N(CC(=O)NC2CCCCC2)Cc2ccc3c(c2)OCO3)c1N nan
CHEMBL1555290 55183 4 None -158 2 Human 5.3 pPotency = 5.3 Functional
PUBCHEM_BIOASSAY: Counterscreen for Agonists of Thyroid Stimulating Hormone Receptor: HTRF Activity in a Follicle Stimulating Hormone Receptor Cell Line. (Class of assay: confirmatory) [Related pubchem assays: 926, 939, 933, 938, 953 ]PUBCHEM_BIOASSAY: Counterscreen for Agonists of Thyroid Stimulating Hormone Receptor: HTRF Activity in a Follicle Stimulating Hormone Receptor Cell Line. (Class of assay: confirmatory) [Related pubchem assays: 926, 939, 933, 938, 953 ]
ChEMBL 459 7 3 8 1.6 NC(=O)c1nsc(C(=O)N(CC(=O)NC2CCCCC2)Cc2ccc3c(c2)OCO3)c1N nan


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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(-log)		 Activity
Type		 Activity
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Type		 Assay
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 DOI
71457922 91112 0 None - 0 Human 9.0 pEC50 = 9 Binding
Allosteric activation of human FSH receptorAllosteric activation of human FSH receptor
ChEMBL 653 10 2 6 5.8 COc1ccc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)N(c3ccc(C(N)=O)c(Cl)c3)C2=O)cc1OC 10.1016/j.bmc.2012.03.069
CHEMBL2216803 91112 0 None - 0 Human 9.0 pEC50 = 9 Binding
Allosteric activation of human FSH receptorAllosteric activation of human FSH receptor
ChEMBL 653 10 2 6 5.8 COc1ccc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)N(c3ccc(C(N)=O)c(Cl)c3)C2=O)cc1OC 10.1016/j.bmc.2012.03.069
71233981 117912 0 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay
ChEMBL 570 10 2 7 4.2 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1021/acsmedchemlett.6b00082
CHEMBL3263667 117912 0 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay
ChEMBL 570 10 2 7 4.2 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1021/acsmedchemlett.6b00082
71234266 117917 0 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay
ChEMBL 555 10 3 9 3.3 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCc3nn[nH]n3)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1021/acsmedchemlett.6b00082
CHEMBL3263691 117917 0 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay
ChEMBL 555 10 3 9 3.3 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCc3nn[nH]n3)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1021/acsmedchemlett.6b00082
71224515 147209 0 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay
ChEMBL 557 9 2 5 4.5 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2ccc(F)cc2)CC1 10.1021/acsmedchemlett.6b00082
CHEMBL3809148 147209 0 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay
ChEMBL 557 9 2 5 4.5 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2ccc(F)cc2)CC1 10.1021/acsmedchemlett.6b00082
CHEMBL5268829 200359 0 None - 0 Human 5.0 pIC50 = 5 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 410 1 1 5 4.4 CC(=O)N1c2cnc(NC(=O)OC(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5285143 201060 0 None - 0 Human 5.0 pIC50 = 5 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 373 3 1 4 4.6 CC(=O)N1c2cnc(NC(=O)OCC(C)C)cc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5285769 201093 0 None - 0 Human 5.0 pIC50 = 5 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 407 3 1 4 5.2 CC(=O)N1c2cnc(NC(=O)OCc3ccccc3)cc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5288869 201224 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 374 3 1 5 4.0 CC(=O)N1c2cnc(NC(=O)OCC(C)C)nc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5267037 200285 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 439 4 1 3 5.7 CC(=O)N1c2ncc(NC(=O)CCc3cccc(Cl)c3)cc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5267043 200287 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 476 3 1 5 5.0 CC(=O)N1c2cnc(NC(=O)OCC3(C(F)(F)F)CC3)nc2C2(CCC(F)(F)CC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5281228 200887 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Allosteric antagonist activity at human FSHR expressed in CHO cells assessed as inhibition of FSH-induced activity incubated for 4 hrs by CRE-luciferase assayAllosteric antagonist activity at human FSHR expressed in CHO cells assessed as inhibition of FSH-induced activity incubated for 4 hrs by CRE-luciferase assay
ChEMBL 480 5 1 2 6.3 CC(=O)N1CCC(C)(c2ccccc2)c2cc(NC(=O)CCc3cccc(C(F)(F)F)c3)ccc21 10.1016/j.bmc.2023.117258
CHEMBL5270771 200429 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 478 3 1 5 5.5 CC(=O)N1c2cnc(NC(=O)OCc3cccc(Cl)c3)nc2C2(CCC(F)(F)CC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5286556 201130 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 438 2 1 5 5.1 CC(=O)N1c2cnc(NC(=O)O[C@H](C)C(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5270266 200406 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 408 3 1 5 4.6 CC(=O)N1c2cnc(NC(=O)OCc3ccccc3)nc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5271120 200449 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 386 2 1 3 5.6 CC(=O)N1c2ccc(NC(=O)OCC(C)(C)C)cc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5290721 201288 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 438 2 1 5 5.1 CC(=O)N1c2cnc(NC(=O)O[C@@H](C)C(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5283477 200990 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 440 3 1 5 4.7 CC(=O)N1c2cnc(NC(=O)OCC3(C(F)(F)F)CC3)nc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5273361 200538 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 424 4 1 2 5.9 CC(=O)N1c2ccc(NC(=O)CCc3cccc(Cl)c3)cc2C2(CCCCC2)C1C 10.1016/j.bmc.2023.117258
CHEMBL5275619 200645 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 388 2 1 5 4.4 CC(=O)N1c2cnc(NC(=O)OCC(C)(C)C)nc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5287707 201169 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 476 4 1 4 5.3 CC(=O)N1c2cnc(NC(=O)CCc3cccc(Cl)c3)nc2C2(CCC(F)(F)CC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5280508 200851 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 438 4 1 2 6.3 CC(=O)N1c2ccc(NC(=O)CCc3cccc(Cl)c3)cc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5279687 200815 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 440 4 1 4 5.0 CC(=O)N1c2cnc(NC(=O)CCc3cccc(Cl)c3)nc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5268512 200347 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 387 2 1 4 5.0 CC(=O)N1c2ncc(NC(=O)OCC(C)(C)C)cc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5267166 200289 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 440 3 1 3 6.4 CC(=O)N1c2ccc(NC(=O)OCc3cccc(Cl)c3)cc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5275140 200619 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 438 3 1 5 5.1 CC(=O)N1c2cnc(NC(=O)OC(C)(C)C(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5285685 201087 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 442 3 1 5 5.2 CC(=O)N1c2cnc(NC(=O)OCc3cccc(Cl)c3)nc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
132072838 188776 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at human FSHR expressed in CHO-K1 cells by PathHunter beta-arrestin assayAntagonist activity at human FSHR expressed in CHO-K1 cells by PathHunter beta-arrestin assay
ChEMBL 565 4 2 6 5.1 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)CCc3c([nH]c4ccccc34)[C@H](OCc3ccc(Br)cc3)C[C@@H]21 10.1016/j.bmc.2020.115546
CHEMBL4780505 188776 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at human FSHR expressed in CHO-K1 cells by PathHunter beta-arrestin assayAntagonist activity at human FSHR expressed in CHO-K1 cells by PathHunter beta-arrestin assay
ChEMBL 565 4 2 6 5.1 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)CCc3c([nH]c4ccccc34)[C@H](OCc3ccc(Br)cc3)C[C@@H]21 10.1016/j.bmc.2020.115546
CHEMBL5288635 201215 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 387 2 1 4 5.0 CC(=O)N1c2ccc(NC(=O)OCC(C)(C)C)nc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5275472 200635 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 424 2 1 5 4.7 CC(=O)N1c2cnc(NC(=O)OCC(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C 10.1016/j.bmc.2023.117258
1158 8477 0 None - 1 Human 10.0 pKd = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8188681