Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
10099401 101209 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 562 15 1 3 6.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL295895 101209 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 562 15 1 3 6.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
10120470 175460 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 563 14 2 4 3.8 CCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL45770 175460 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 563 14 2 4 3.8 CCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
44293169 183153 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 551 14 0 5 5.5 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL47953 183153 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 551 14 0 5 5.5 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293020 180231 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 482 11 0 5 4.6 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL47500 180231 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 482 11 0 5 4.6 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
71224515 140431 0 None - 1 Human 7.0 pEC50 = 7 Functional
Positive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF assayPositive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 557 9 2 5 4.5 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2ccc(F)cc2)CC1 10.1021/acsmedchemlett.6b00082
CHEMBL3809148 140431 0 None - 1 Human 7.0 pEC50 = 7 Functional
Positive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF assayPositive allosteric modulation of FSHR (unknown origin) expressed in CHO cells assessed as FSH-induced cAMP accumulation incubated for 1 hr by HTRF assay
ChEMBL 557 9 2 5 4.5 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2ccc(F)cc2)CC1 10.1021/acsmedchemlett.6b00082
44293287 187331 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL49308 187331 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@H]1C 10.1016/j.bmcl.2004.01.043
44293019 162667 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 464 11 0 3 5.6 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(C)c(OC)c(C)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL417003 162667 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 464 11 0 3 5.6 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(C)c(OC)c(C)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
53322111 57366 0 None -125 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 482 7 4 8 3.4 C#CCNC(=O)CNc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1 10.1021/ml100229v
CHEMBL1651721 57366 0 None -125 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 482 7 4 8 3.4 C#CCNC(=O)CNc1cccc(-c2nc(SC)nc3sc(C(=O)NC(C)(C)C)c(N)c23)c1 10.1021/ml100229v
10164519 187849 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL49624 187849 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292938 178965 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 547 15 0 3 6.5 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL47059 178965 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 547 15 0 3 6.5 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292917 171672 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 519 13 0 3 5.7 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL44663 171672 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 519 13 0 3 5.7 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292891 187725 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL49540 187725 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@H]1C 10.1016/j.bmcl.2004.01.043
10030777 168185 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 563 15 0 4 6.7 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL433263 168185 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 563 15 0 4 6.7 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293324 101593 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 482 12 0 5 4.6 CCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL298686 101593 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 482 12 0 5 4.6 CCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
44293289 98963 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 496 12 0 5 5.0 CCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL279759 98963 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 496 12 0 5 5.0 CCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292945 162762 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 563 15 2 4 4.8 CCCCCCNC(=O)CN1C(=O)C(Cc2ccc(-c3ccc(CN(CCCC)C(=O)NC)cc3)cc2)N(C)C1=O 10.1016/j.bmcl.2004.01.042
CHEMBL417173 162762 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 563 15 2 4 4.8 CCCCCCNC(=O)CN1C(=O)C(Cc2ccc(-c3ccc(CN(CCCC)C(=O)NC)cc3)cc2)N(C)C1=O 10.1016/j.bmcl.2004.01.042
10461880 188770 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 645 13 3 4 5.4 CCCCN(Cc1cccc(-c2ccc(C(=O)NC3CCCCN(CC(=O)NCCc4ccc(Cl)cc4)C3=O)cc2)c1)C(=O)NC 10.1016/j.bmcl.2004.01.042
CHEMBL50556 188770 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 645 13 3 4 5.4 CCCCN(Cc1cccc(-c2ccc(C(=O)NC3CCCCN(CC(=O)NCCc4ccc(Cl)cc4)C3=O)cc2)c1)C(=O)NC 10.1016/j.bmcl.2004.01.042
71234037 111139 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 531 9 2 7 3.7 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCOC3=O)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263689 111139 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 531 9 2 7 3.7 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCOC3=O)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
10142987 101784 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 525 13 1 6 3.3 CCCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL300022 101784 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 525 13 1 6 3.3 CCCCCCNC(=O)CN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
44292731 183680 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 550 14 1 4 5.1 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL48030 183680 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 550 14 1 4 5.1 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292995 188457 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 468 11 0 5 4.2 CCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL50278 188457 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 468 11 0 5 4.2 CCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
71233908 111136 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 515 8 2 6 3.5 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCN3CCCC3=O)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263683 111136 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 515 8 2 6 3.5 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCN3CCCC3=O)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
10030777 168185 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 563 15 0 4 6.7 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL433263 168185 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 563 15 0 4 6.7 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
10164519 187849 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL49624 187849 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293289 98963 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFollicle stimulating hormone receptor cell-based cAMP accumulation assayAgonistic activity in CHO-hFollicle stimulating hormone receptor cell-based cAMP accumulation assay
ChEMBL 496 12 0 5 5.0 CCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL279759 98963 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFollicle stimulating hormone receptor cell-based cAMP accumulation assayAgonistic activity in CHO-hFollicle stimulating hormone receptor cell-based cAMP accumulation assay
ChEMBL 496 12 0 5 5.0 CCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293018 179579 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 466 12 0 4 4.9 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3ccc(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL47420 179579 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 466 12 0 4 4.9 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3ccc(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
44292938 178965 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 547 15 0 3 6.5 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL47059 178965 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 547 15 0 3 6.5 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
10165009 179021 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 521 15 1 4 5.8 CCCCOC(=O)N(CC(=O)NCC1CC1)Cc1ccc(-c2ccccc2CN(CCCC)C(C)=O)cc1 10.1016/j.bmcl.2004.01.042
CHEMBL47120 179021 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)Agonistic activity against Follicle stimulating hormone receptor expressed in chinese hamster ovary cells(CHO)
ChEMBL 521 15 1 4 5.8 CCCCOC(=O)N(CC(=O)NCC1CC1)Cc1ccc(-c2ccccc2CN(CCCC)C(C)=O)cc1 10.1016/j.bmcl.2004.01.042
44255904 57384 0 None -79 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 682 17 4 14 3.9 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCN=[N+]=[N-])nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651828 57384 0 None -79 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assayAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as stimulation of luciferase activity by CRE-driven luciferase reporter gene assay
ChEMBL 682 17 4 14 3.9 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCN=[N+]=[N-])nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
10185204 176594 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 496 13 0 5 5.0 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL45976 176594 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 496 13 0 5 5.0 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
2837084 71139 16 None - 1 Human 5.4 pEC50 = 5.4 Functional
Effective concentration for maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorEffective concentration for maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 308 1 1 2 4.1 CC(=O)N1c2ccc(N)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL195534 71139 16 None - 1 Human 5.4 pEC50 = 5.4 Functional
Effective concentration for maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorEffective concentration for maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 308 1 1 2 4.1 CC(=O)N1c2ccc(N)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
71234065 111137 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 537 8 3 6 4.2 Cc1ccccc1N1CCN(c2ccc(C(=O)NCc3cccc(C(N)=O)c3)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263685 111137 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 537 8 3 6 4.2 Cc1ccccc1N1CCN(c2ccc(C(=O)NCc3cccc(C(N)=O)c3)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
44293203 184258 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 535 13 0 4 5.9 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL48375 184258 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 535 13 0 4 5.9 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
71450781 84338 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human FSH receptor by aromatase-based assayAgonist activity at human FSH receptor by aromatase-based assay
ChEMBL 514 9 2 5 4.5 CCOc1cc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)NC2=O)ccc1OC 10.1016/j.bmc.2012.03.069
CHEMBL2216804 84338 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human FSH receptor by aromatase-based assayAgonist activity at human FSH receptor by aromatase-based assay
ChEMBL 514 9 2 5 4.5 CCOc1cc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)NC2=O)ccc1OC 10.1016/j.bmc.2012.03.069
44580873 193322 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human recombinant FSH receptorAgonist activity at human recombinant FSH receptor
ChEMBL 561 9 2 5 5.1 COc1ccc(C2SC(CC(=O)NCCC3=CCc4ccccc43)C(=O)N2c2ccc(C(N)=O)c(Cl)c2)cc1 10.1016/j.ejmech.2007.07.017
CHEMBL524348 193322 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human recombinant FSH receptorAgonist activity at human recombinant FSH receptor
ChEMBL 561 9 2 5 5.1 COc1ccc(C2SC(CC(=O)NCCC3=CCc4ccccc43)C(=O)N2c2ccc(C(N)=O)c(Cl)c2)cc1 10.1016/j.ejmech.2007.07.017
44293299 175524 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 466 12 0 4 4.9 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)cc(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL45782 175524 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 466 12 0 4 4.9 CCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)cc(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
71224679 111141 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 559 7 4 8 3.4 Cc1ccccc1N1CCN(c2ccc(C(=O)N[C@@H]3CCC[C@@H](O)[C@H]3O)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263692 111141 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 559 7 4 8 3.4 Cc1ccccc1N1CCN(c2ccc(C(=O)N[C@@H]3CCC[C@@H](O)[C@H]3O)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1016/j.bmcl.2014.03.018
44293203 184258 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 535 13 0 4 5.9 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL48375 184258 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 535 13 0 4 5.9 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292920 101291 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL296449 101291 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 13 0 5 5.3 CCCCCCCCN1C(=O)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293189 187828 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 534 13 1 3 5.5 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL49608 187828 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 534 13 1 3 5.5 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
10099401 101209 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 562 15 1 3 6.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL295895 101209 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 562 15 1 3 6.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293203 184258 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 535 13 0 4 5.9 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL48375 184258 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 535 13 0 4 5.9 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)OC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
71450781 84338 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human FSH receptor by cAMP-based assayAgonist activity at human FSH receptor by cAMP-based assay
ChEMBL 514 9 2 5 4.5 CCOc1cc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)NC2=O)ccc1OC 10.1016/j.bmc.2012.03.069
CHEMBL2216804 84338 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human FSH receptor by cAMP-based assayAgonist activity at human FSH receptor by cAMP-based assay
ChEMBL 514 9 2 5 4.5 CCOc1cc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)NC2=O)ccc1OC 10.1016/j.bmc.2012.03.069
71234040 111138 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 516 9 2 6 4.7 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCC3CCOC3)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263687 111138 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 516 9 2 6 4.7 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCC3CCOC3)cc2NC(=O)c2ccco2)CC1 10.1016/j.bmcl.2014.03.018
71234266 111140 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 555 10 3 9 3.3 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCc3nn[nH]n3)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263691 111140 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 555 10 3 9 3.3 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCc3nn[nH]n3)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1016/j.bmcl.2014.03.018
44293189 187828 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 534 13 1 3 5.5 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL49608 187828 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonistic activity in CHO-hFSHR cell-based cAMP accumulation assayAgonistic activity in CHO-hFSHR cell-based cAMP accumulation assay
ChEMBL 534 13 1 3 5.5 CCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(CCCC)C(=O)NC)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44293172 176944 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 535 14 0 4 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
CHEMBL46216 176944 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 535 14 0 4 5.3 CCCCCCCCN1C(=O)[C@H](Cc2ccc(-c3cccc(CN(COC)C(C)=O)c3)cc2)N(C)C(=O)[C@@H]1C 10.1016/j.bmcl.2004.01.043
44292698 182267 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 14 0 5 5.3 CCCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL47838 182267 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 510 14 0 5 5.3 CCCCCCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
44293300 168118 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 454 10 0 5 3.8 CCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
CHEMBL432883 168118 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.Agonistic activity against human follicle stimulating hormone receptor in CHO-hFSHR-luciferase assay.
ChEMBL 454 10 0 5 3.8 CCCCCN1CC(=O)N(C)[C@@H](Cc2ccc(-c3cc(OC)c(OC)c(OC)c3)cc2)C1=O 10.1016/j.bmcl.2004.01.043
71233981 111135 0 None - 1 Human 4.0 pEC50 = 4 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 570 10 2 7 4.2 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1016/j.bmcl.2014.03.018
CHEMBL3263667 111135 0 None - 1 Human 4.0 pEC50 = 4 Functional
Positive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assayPositive allosteric modulation of human FSH receptor expressed in CHO cells assessed as effect on FSH-induced cAMP accumulation after 1 hr by HTRF assay
ChEMBL 570 10 2 7 4.2 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1016/j.bmcl.2014.03.018
11260332 68679 0 None 51 2 Human 8.0 pIC50 = 8 Functional
In vitro inhibition of maximum response evoked by cAMP on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response evoked by cAMP on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL192135 68679 0 None 51 2 Human 8.0 pIC50 = 8 Functional
In vitro inhibition of maximum response evoked by cAMP on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response evoked by cAMP on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
53324743 57382 0 None -18 2 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 1313 30 5 21 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651826 57382 0 None -18 2 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 1313 30 5 21 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
11190706 135277 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 475 5 0 2 7.8 CC(=O)N1c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL372649 135277 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 475 5 0 2 7.8 CC(=O)N1c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
53324742 57381 0 None -26 2 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 1269 27 5 20 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651825 57381 0 None -26 2 Human 5.8 pIC50 = 5.8 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 1269 27 5 20 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
11352881 166252 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 518 5 1 3 7.5 COc1ccccc1C1(C)CC(C)(C)N(C(C)=O)c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc21 10.1021/jm049676l
CHEMBL426824 166252 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 518 5 1 3 7.5 COc1ccccc1C1(C)CC(C)(C)N(C(C)=O)c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc21 10.1021/jm049676l
11442786 71090 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 470 6 1 3 5.5 COc1ccc(CCNC(=O)c2ccc3c(c2)C(C)(c2ccccc2)CC(C)(C)N3C(C)=O)cc1 10.1021/jm049676l
CHEMBL195321 71090 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 470 6 1 3 5.5 COc1ccc(CCNC(=O)c2ccc3c(c2)C(C)(c2ccccc2)CC(C)(C)N3C(C)=O)cc1 10.1021/jm049676l
11156384 124056 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 504 4 2 3 7.2 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccc(O)cc2)CC1(C)C 10.1021/jm049676l
CHEMBL363164 124056 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 504 4 2 3 7.2 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccc(O)cc2)CC1(C)C 10.1021/jm049676l
11306348 71122 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL195469 71122 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccccc3-c3ccccc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11258158 123125 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 402 3 1 3 5.4 CC(=O)N1c2ccc(NC(=O)c3ccco3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL361167 123125 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 402 3 1 3 5.4 CC(=O)N1c2ccc(NC(=O)c3ccco3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11260332 68679 0 None 51 2 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL192135 68679 0 None 51 2 Human 7.6 pIC50 = 7.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11431176 133967 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 462 5 1 3 5.5 CC(=O)N1c2ccc(NS(=O)(=O)Cc3ccccc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL371595 133967 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 462 5 1 3 5.5 CC(=O)N1c2ccc(NS(=O)(=O)Cc3ccccc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11203161 69324 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 518 5 1 3 7.5 COc1cc(NC(=O)c2ccc(-c3ccccc3)cc2)cc2c1N(C(C)=O)C(C)(C)CC2(C)c1ccccc1 10.1021/jm049676l
CHEMBL192868 69324 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 518 5 1 3 7.5 COc1cc(NC(=O)c2ccc(-c3ccccc3)cc2)cc2c1N(C(C)=O)C(C)(C)CC2(C)c1ccccc1 10.1021/jm049676l
11224637 63164 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 446 3 1 2 6.4 CC(=O)N1c2ccc(NC(=O)c3ccc(Cl)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL178980 63164 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 446 3 1 2 6.4 CC(=O)N1c2ccc(NC(=O)c3ccc(Cl)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
53326035 57383 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 742 16 1 9 8.0 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2[C@@](C)(c2ccc(OCc3cn(CCOCCOCCN=[N+]=[N-])nn3)cc2)CC1(C)C 10.1021/ml100229v
CHEMBL1651827 57383 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 742 16 1 9 8.0 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2[C@@](C)(c2ccc(OCc3cn(CCOCCOCCN=[N+]=[N-])nn3)cc2)CC1(C)C 10.1021/ml100229v
53318154 57367 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 542 6 1 3 7.5 C#CCOc1ccc([C@@]2(C)CC(C)(C)N(C(C)=O)c3ccc(NC(=O)c4ccc(-c5ccccc5)cc4)cc32)cc1 10.1021/ml100229v
CHEMBL1651722 57367 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 542 6 1 3 7.5 C#CCOc1ccc([C@@]2(C)CC(C)(C)N(C(C)=O)c3ccc(NC(=O)c4ccc(-c5ccccc5)cc4)cc32)cc1 10.1021/ml100229v
11260332 68679 0 None 51 2 Human 8.4 pIC50 = 8.4 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL192135 68679 0 None 51 2 Human 8.4 pIC50 = 8.4 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11396885 123086 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 454 5 1 2 6.7 CCCc1ccc(C(=O)Nc2ccc3c(c2)C(C)(c2ccccc2)CC(C)(C)N3C(C)=O)cc1 10.1021/jm049676l
CHEMBL360981 123086 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 454 5 1 2 6.7 CCCc1ccc(C(=O)Nc2ccc3c(c2)C(C)(c2ccccc2)CC(C)(C)N3C(C)=O)cc1 10.1021/jm049676l
11283470 168674 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 502 4 1 2 7.8 CC(=O)N1c2cc(C)c(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL436481 168674 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 502 4 1 2 7.8 CC(=O)N1c2cc(C)c(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11375523 71095 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 502 4 1 2 7.8 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccc(C)cc2)CC1(C)C 10.1021/jm049676l
CHEMBL195347 71095 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 502 4 1 2 7.8 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccc(C)cc2)CC1(C)C 10.1021/jm049676l
11443213 69006 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 489 4 0 3 7.4 CC(=O)N1c2ccc(OC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL192334 69006 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 489 4 0 3 7.4 CC(=O)N1c2ccc(OC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11260332 68679 0 None -51 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro inhibition against maximum response evoked by cAMP in rat GFSHR-17 granulosa cell lineIn vitro inhibition against maximum response evoked by cAMP in rat GFSHR-17 granulosa cell line
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL192135 68679 0 None -51 2 Rat 6.3 pIC50 = 6.3 Functional
In vitro inhibition against maximum response evoked by cAMP in rat GFSHR-17 granulosa cell lineIn vitro inhibition against maximum response evoked by cAMP in rat GFSHR-17 granulosa cell line
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3ccc(-c4ccccc4)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11407702 135243 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 427 3 2 2 6.2 CC(=O)N1c2ccc(NC(=O)Nc3ccccc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL372506 135243 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 427 3 2 2 6.2 CC(=O)N1c2ccc(NC(=O)Nc3ccccc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11190814 123621 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 480 3 1 2 6.8 CC(=O)N1c2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL361847 123621 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 480 3 1 2 6.8 CC(=O)N1c2ccc(NC(=O)c3ccc(C(F)(F)F)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11373573 63362 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 422 4 1 3 5.3 CC(=O)N1c2ccc(NC(=O)COC(C)(C)C)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL179505 63362 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 422 4 1 3 5.3 CC(=O)N1c2ccc(NC(=O)COC(C)(C)C)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
11283209 126884 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3cccc(-c4ccccc4)c3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL365545 126884 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 488 4 1 2 7.4 CC(=O)N1c2ccc(NC(=O)c3cccc(-c4ccccc4)c3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
53320758 57380 0 None -21 2 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 1225 24 5 19 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
CHEMBL1651824 57380 0 None -21 2 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to controlAgonist activity at human FSHR receptor expressed in CHO-K1 cells assessed as inhibition of FSH-induced luciferase activity by CRE-driven luciferase reporter gene assay relative to control
ChEMBL 1225 24 5 19 10.2 CSc1nc(-c2cccc(NCC(=O)NCc3cn(CCOCCOCCn4cc(COc5ccc([C@@]6(C)CC(C)(C)N(C(C)=O)c7ccc(NC(=O)c8ccc(-c9ccccc9)cc8)cc76)cc5)nn4)nn3)c2)c2c(N)c(C(=O)NC(C)(C)C)sc2n1 10.1021/ml100229v
11224817 70624 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 454 4 1 2 7.4 CC(=O)N1c2ccc(NCc3ccc(C(C)(C)C)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL194996 70624 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptorIn vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
ChEMBL 454 4 1 2 7.4 CC(=O)N1c2ccc(NCc3ccc(C(C)(C)C)cc3)cc2C(C)(c2ccccc2)CC1(C)C 10.1021/jm049676l
CHEMBL2369814 209692 0 None - 0 Rat 7.2 pKd = 7.2 Functional
Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL None None None CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00130a019
14557576 89375 0 None - 0 Rat 6.1 pKd = 6.1 Functional
Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL 961 26 12 11 -0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00130a019
CHEMBL2369794 89375 0 None - 0 Rat 6.1 pKd = 6.1 Functional
Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)Luteinizing hormone inhibiting potency in rats is expressed as negative logarithm of the concentration (antagonist)
ChEMBL 961 26 12 11 -0.3 CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1021/jm00130a019
3172428 48409 4 None -158 2 Human 5.3 pPotency = 5.3 Functional
PUBCHEM_BIOASSAY: Counterscreen for Agonists of Thyroid Stimulating Hormone Receptor: HTRF Activity in a Follicle Stimulating Hormone Receptor Cell Line. (Class of assay: confirmatory) [Related pubchem assays: 926, 939, 933, 938, 953 ]PUBCHEM_BIOASSAY: Counterscreen for Agonists of Thyroid Stimulating Hormone Receptor: HTRF Activity in a Follicle Stimulating Hormone Receptor Cell Line. (Class of assay: confirmatory) [Related pubchem assays: 926, 939, 933, 938, 953 ]
ChEMBL 459 7 3 8 1.6 NC(=O)c1nsc(C(=O)N(CC(=O)NC2CCCCC2)Cc2ccc3c(c2)OCO3)c1N nan
CHEMBL1555290 48409 4 None -158 2 Human 5.3 pPotency = 5.3 Functional
PUBCHEM_BIOASSAY: Counterscreen for Agonists of Thyroid Stimulating Hormone Receptor: HTRF Activity in a Follicle Stimulating Hormone Receptor Cell Line. (Class of assay: confirmatory) [Related pubchem assays: 926, 939, 933, 938, 953 ]PUBCHEM_BIOASSAY: Counterscreen for Agonists of Thyroid Stimulating Hormone Receptor: HTRF Activity in a Follicle Stimulating Hormone Receptor Cell Line. (Class of assay: confirmatory) [Related pubchem assays: 926, 939, 933, 938, 953 ]
ChEMBL 459 7 3 8 1.6 NC(=O)c1nsc(C(=O)N(CC(=O)NC2CCCCC2)Cc2ccc3c(c2)OCO3)c1N nan


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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 p-value
(-log)		 Activity
Type		 Activity
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Type		 Assay
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 DOI
71457922 84337 0 None - 0 Human 9.0 pEC50 = 9 Binding
Allosteric activation of human FSH receptorAllosteric activation of human FSH receptor
ChEMBL 653 10 2 6 5.8 COc1ccc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)N(c3ccc(C(N)=O)c(Cl)c3)C2=O)cc1OC 10.1016/j.bmc.2012.03.069
CHEMBL2216803 84337 0 None - 0 Human 9.0 pEC50 = 9 Binding
Allosteric activation of human FSH receptorAllosteric activation of human FSH receptor
ChEMBL 653 10 2 6 5.8 COc1ccc(CCNC(=O)C[C@H]2S[C@@H](c3ccc(C#Cc4ccccc4)cc3)N(c3ccc(C(N)=O)c(Cl)c3)C2=O)cc1OC 10.1016/j.bmc.2012.03.069
71233981 111135 0 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay
ChEMBL 570 10 2 7 4.2 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1021/acsmedchemlett.6b00082
CHEMBL3263667 111135 0 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay
ChEMBL 570 10 2 7 4.2 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1021/acsmedchemlett.6b00082
71234266 111140 0 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay
ChEMBL 555 10 3 9 3.3 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCc3nn[nH]n3)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1021/acsmedchemlett.6b00082
CHEMBL3263691 111140 0 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay
ChEMBL 555 10 3 9 3.3 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCc3nn[nH]n3)cc2NC(=O)c2coc(C3CC3)n2)CC1 10.1021/acsmedchemlett.6b00082
71224515 140431 0 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay
ChEMBL 557 9 2 5 4.5 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2ccc(F)cc2)CC1 10.1021/acsmedchemlett.6b00082
CHEMBL3809148 140431 0 None - 0 Human 7.0 pEC50 = 7 Binding
Positive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossayPositive allosteric modulation of human FSHR expressed in rat granulocytes assessed as FSH-induced estradiol production after 72 hrs by radioimmunossay
ChEMBL 557 9 2 5 4.5 Cc1ccccc1N1CCN(c2ccc(C(=O)NCCCN3CCCC3=O)cc2NC(=O)c2ccc(F)cc2)CC1 10.1021/acsmedchemlett.6b00082
CHEMBL5268829 193580 0 None - 0 Human 5.0 pIC50 = 5 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 410 1 1 5 4.4 CC(=O)N1c2cnc(NC(=O)OC(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5285143 194281 0 None - 0 Human 5.0 pIC50 = 5 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 373 3 1 4 4.6 CC(=O)N1c2cnc(NC(=O)OCC(C)C)cc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5285769 194314 0 None - 0 Human 5.0 pIC50 = 5 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 407 3 1 4 5.2 CC(=O)N1c2cnc(NC(=O)OCc3ccccc3)cc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5288869 194445 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 374 3 1 5 4.0 CC(=O)N1c2cnc(NC(=O)OCC(C)C)nc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5267037 193506 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 439 4 1 3 5.7 CC(=O)N1c2ncc(NC(=O)CCc3cccc(Cl)c3)cc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5267043 193508 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 476 3 1 5 5.0 CC(=O)N1c2cnc(NC(=O)OCC3(C(F)(F)F)CC3)nc2C2(CCC(F)(F)CC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5281228 194108 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Allosteric antagonist activity at human FSHR expressed in CHO cells assessed as inhibition of FSH-induced activity incubated for 4 hrs by CRE-luciferase assayAllosteric antagonist activity at human FSHR expressed in CHO cells assessed as inhibition of FSH-induced activity incubated for 4 hrs by CRE-luciferase assay
ChEMBL 480 5 1 2 6.3 CC(=O)N1CCC(C)(c2ccccc2)c2cc(NC(=O)CCc3cccc(C(F)(F)F)c3)ccc21 10.1016/j.bmc.2023.117258
CHEMBL5270771 193650 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 478 3 1 5 5.5 CC(=O)N1c2cnc(NC(=O)OCc3cccc(Cl)c3)nc2C2(CCC(F)(F)CC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5286556 194351 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 438 2 1 5 5.1 CC(=O)N1c2cnc(NC(=O)O[C@H](C)C(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5270266 193627 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 408 3 1 5 4.6 CC(=O)N1c2cnc(NC(=O)OCc3ccccc3)nc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5271120 193670 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 386 2 1 3 5.6 CC(=O)N1c2ccc(NC(=O)OCC(C)(C)C)cc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5290721 194509 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 438 2 1 5 5.1 CC(=O)N1c2cnc(NC(=O)O[C@@H](C)C(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5283477 194211 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 440 3 1 5 4.7 CC(=O)N1c2cnc(NC(=O)OCC3(C(F)(F)F)CC3)nc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5273361 193759 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 424 4 1 2 5.9 CC(=O)N1c2ccc(NC(=O)CCc3cccc(Cl)c3)cc2C2(CCCCC2)C1C 10.1016/j.bmc.2023.117258
CHEMBL5275619 193866 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 388 2 1 5 4.4 CC(=O)N1c2cnc(NC(=O)OCC(C)(C)C)nc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5287707 194390 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 476 4 1 4 5.3 CC(=O)N1c2cnc(NC(=O)CCc3cccc(Cl)c3)nc2C2(CCC(F)(F)CC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5280508 194072 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 438 4 1 2 6.3 CC(=O)N1c2ccc(NC(=O)CCc3cccc(Cl)c3)cc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5279687 194036 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 440 4 1 4 5.0 CC(=O)N1c2cnc(NC(=O)CCc3cccc(Cl)c3)nc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5268512 193568 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 387 2 1 4 5.0 CC(=O)N1c2ncc(NC(=O)OCC(C)(C)C)cc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5267166 193510 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 440 3 1 3 6.4 CC(=O)N1c2ccc(NC(=O)OCc3cccc(Cl)c3)cc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5275140 193840 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 438 3 1 5 5.1 CC(=O)N1c2cnc(NC(=O)OC(C)(C)C(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5285685 194308 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 442 3 1 5 5.2 CC(=O)N1c2cnc(NC(=O)OCc3cccc(Cl)c3)nc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
132072838 181997 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at human FSHR expressed in CHO-K1 cells by PathHunter beta-arrestin assayAntagonist activity at human FSHR expressed in CHO-K1 cells by PathHunter beta-arrestin assay
ChEMBL 565 4 2 6 5.1 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)CCc3c([nH]c4ccccc34)[C@H](OCc3ccc(Br)cc3)C[C@@H]21 10.1016/j.bmc.2020.115546
CHEMBL4780505 181997 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at human FSHR expressed in CHO-K1 cells by PathHunter beta-arrestin assayAntagonist activity at human FSHR expressed in CHO-K1 cells by PathHunter beta-arrestin assay
ChEMBL 565 4 2 6 5.1 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN(C#N)CCc3c([nH]c4ccccc34)[C@H](OCc3ccc(Br)cc3)C[C@@H]21 10.1016/j.bmc.2020.115546
CHEMBL5288635 194436 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 387 2 1 4 5.0 CC(=O)N1c2ccc(NC(=O)OCC(C)(C)C)nc2C2(CCCCC2)C1(C)C 10.1016/j.bmc.2023.117258
CHEMBL5275472 193856 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Antagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assayAntagonist activity at human FSHR expressed in HEK293 cells assessed as reduction in cAMP production incubated for 2 hrs by Eu-cAMP tracer based TR-FRET assay
ChEMBL 424 2 1 5 4.7 CC(=O)N1c2cnc(NC(=O)OCC(C)(C)C)nc2C2(CCC(F)(F)CC2)C1(C)C 10.1016/j.bmc.2023.117258
1158 1696 0 None - 1 Human 10.0 pKd = 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8188681