Ligand source activities (1 row/activity)





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DOI

155513981 176604 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 412 3 2 4 5.3 CC1=C(C(=O)Nc2ccccc2C)C(c2cc3ccccc3o2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4439667 176604 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 412 3 2 4 5.3 CC1=C(C(=O)Nc2ccccc2C)C(c2cc3ccccc3o2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155519653 177142 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 352 4 2 3 4.5 CCC(C)C1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
CHEMBL4447610 177142 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 352 4 2 3 4.5 CCC(C)C1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
155534079 178707 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 352 4 2 3 4.5 CC1=C(C(=O)Nc2ccccc2C)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4470184 178707 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 352 4 2 3 4.5 CC1=C(C(=O)Nc2ccccc2C)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
5222465 209604 89 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at GPR41 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR41 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 110 2 0 2 -3.5 CCCC(=O)[O-].[Na+] 10.1021/acsmedchemlett.6b00025
CHEMBL62381 209604 89 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at GPR41 (unknown origin) by Fluo-4 AM dye based calcium mobilization assayAgonist activity at GPR41 (unknown origin) by Fluo-4 AM dye based calcium mobilization assay
ChEMBL 110 2 0 2 -3.5 CCCC(=O)[O-].[Na+] 10.1021/acsmedchemlett.6b00025
155518312 177052 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 366 4 2 3 4.8 CC1=C(C(=O)Nc2cccc(C)c2C)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4446176 177052 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 366 4 2 3 4.8 CC1=C(C(=O)Nc2cccc(C)c2C)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155532033 178489 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 374 4 2 3 4.5 CC1=C(C(=O)Nc2c(F)cccc2F)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4466772 178489 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 374 4 2 3 4.5 CC1=C(C(=O)Nc2c(F)cccc2F)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155521449 177333 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 358 4 2 3 4.6 CCCC1C(C(=O)Nc2cccc(Cl)c2)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
CHEMBL4450056 177333 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 358 4 2 3 4.6 CCCC1C(C(=O)Nc2cccc(Cl)c2)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
1032 9959 78 None 8 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 74 1 1 1 0.5 CCC(=O)O 10.1021/acs.jmedchem.9b02036
1062 9959 78 None 8 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 74 1 1 1 0.5 CCC(=O)O 10.1021/acs.jmedchem.9b02036
CHEMBL14021 9959 78 None 8 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 74 1 1 1 0.5 CCC(=O)O 10.1021/acs.jmedchem.9b02036
DB03766 9959 78 None 8 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 74 1 1 1 0.5 CCC(=O)O 10.1021/acs.jmedchem.9b02036
651809 177303 4 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 376 3 2 4 4.5 CC1=C(C(=O)Nc2ccccc2C)C(c2ccc(C)o2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4449702 177303 4 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 376 3 2 4 4.5 CC1=C(C(=O)Nc2ccccc2C)C(c2ccc(C)o2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155538299 179181 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 388 5 2 4 4.6 CCCC1C(C(=O)Nc2cc(OC)ccc2Cl)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
CHEMBL4476587 179181 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 388 5 2 4 4.6 CCCC1C(C(=O)Nc2cc(OC)ccc2Cl)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
155535425 178867 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 444 5 2 5 4.7 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(CCn2cccn2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4472390 178867 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 444 5 2 5 4.7 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(CCn2cccn2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
1032 9959 78 None 8 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 74 1 1 1 0.5 CCC(=O)O 10.1021/acs.jmedchem.9b02036
1062 9959 78 None 8 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 74 1 1 1 0.5 CCC(=O)O 10.1021/acs.jmedchem.9b02036
CHEMBL14021 9959 78 None 8 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 74 1 1 1 0.5 CCC(=O)O 10.1021/acs.jmedchem.9b02036
DB03766 9959 78 None 8 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 74 1 1 1 0.5 CCC(=O)O 10.1021/acs.jmedchem.9b02036
1058 7042 85 None -3 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
ChEMBL 60 0 1 1 0.1 CC(=O)O 10.1021/acs.jmedchem.7b00244
176 7042 85 None -3 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
ChEMBL 60 0 1 1 0.1 CC(=O)O 10.1021/acs.jmedchem.7b00244
21980959 7042 85 None -3 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
ChEMBL 60 0 1 1 0.1 CC(=O)O 10.1021/acs.jmedchem.7b00244
4211 7042 85 None -3 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
ChEMBL 60 0 1 1 0.1 CC(=O)O 10.1021/acs.jmedchem.7b00244
CHEMBL539 7042 85 None -3 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
ChEMBL 60 0 1 1 0.1 CC(=O)O 10.1021/acs.jmedchem.7b00244
DB03166 7042 85 None -3 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
ChEMBL 60 0 1 1 0.1 CC(=O)O 10.1021/acs.jmedchem.7b00244
1059 7537 81 None 7 3 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
ChEMBL 88 2 1 1 0.9 CCCC(=O)O 10.1021/acs.jmedchem.7b00244
264 7537 81 None 7 3 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
ChEMBL 88 2 1 1 0.9 CCCC(=O)O 10.1021/acs.jmedchem.7b00244
CHEMBL14227 7537 81 None 7 3 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
ChEMBL 88 2 1 1 0.9 CCCC(=O)O 10.1021/acs.jmedchem.7b00244
DB03568 7537 81 None 7 3 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
ChEMBL 88 2 1 1 0.9 CCCC(=O)O 10.1021/acs.jmedchem.7b00244
1032 9959 78 None 8 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
ChEMBL 74 1 1 1 0.5 CCC(=O)O 10.1021/acs.jmedchem.7b00244
1062 9959 78 None 8 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
ChEMBL 74 1 1 1 0.5 CCC(=O)O 10.1021/acs.jmedchem.7b00244
CHEMBL14021 9959 78 None 8 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
ChEMBL 74 1 1 1 0.5 CCC(=O)O 10.1021/acs.jmedchem.7b00244
DB03766 9959 78 None 8 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
ChEMBL 74 1 1 1 0.5 CCC(=O)O 10.1021/acs.jmedchem.7b00244
155526048 177868 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 338 4 2 3 4.2 CCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
CHEMBL4457531 177868 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 338 4 2 3 4.2 CCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
3142523 181948 7 None - 1 Human 5.9 pEC50 = 5.9 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 378 3 2 4 4.7 CC1=C(C(=O)Nc2ccccc2C)C(c2cccs2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4570341 181948 7 None - 1 Human 5.9 pEC50 = 5.9 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 378 3 2 4 4.7 CC1=C(C(=O)Nc2ccccc2C)C(c2cccs2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
129743659 182324 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 372 3 2 3 4.6 CC1=C(C(=O)Nc2ccccc2C)C(c2ccccc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4578663 182324 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 372 3 2 3 4.6 CC1=C(C(=O)Nc2ccccc2C)C(c2ccccc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
91885415 181681 31 None -1 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 416 3 2 4 5.2 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4564389 181681 31 None -1 3 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 416 3 2 4 5.2 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
3142525 182132 11 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 450 3 2 3 5.4 CC1=C(C(=O)Nc2ccccc2C)C(c2cccc(Br)c2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4574477 182132 11 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 450 3 2 3 5.4 CC1=C(C(=O)Nc2ccccc2C)C(c2cccc(Br)c2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155535071 178784 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 392 3 2 4 5.0 CC1=C(C(=O)Nc2ccccc2C)C(c2cc(C)cs2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4471380 178784 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 392 3 2 4 5.0 CC1=C(C(=O)Nc2ccccc2C)C(c2cc(C)cs2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155561832 182598 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 352 5 2 3 4.6 CCCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
CHEMBL4584743 182598 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 352 5 2 3 4.6 CCCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
155511466 176374 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 392 4 2 3 5.2 CCCC1C(C(=O)Nc2cc(Cl)ccc2Cl)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
CHEMBL4436229 176374 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 392 4 2 3 5.2 CCCC1C(C(=O)Nc2cc(Cl)ccc2Cl)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
155518116 177057 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 440 3 2 3 5.6 CC1=C(C(=O)Nc2ccccc2C)C(c2cccc(C(F)(F)F)c2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4446232 177057 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 440 3 2 3 5.6 CC1=C(C(=O)Nc2ccccc2C)C(c2cccc(C(F)(F)F)c2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155534056 178716 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 362 3 2 4 4.2 CC1=C(C(=O)Nc2cccc(C)c2)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4470372 178716 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 362 3 2 4 4.2 CC1=C(C(=O)Nc2cccc(C)c2)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155546001 180284 0 None 2 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 418 3 2 3 5.6 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(C2CCCC2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4530642 180284 0 None 2 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 418 3 2 3 5.6 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(C2CCCC2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
3144726 179732 11 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 450 3 2 3 5.4 CC1=C(C(=O)Nc2ccccc2C)C(c2ccc(Br)cc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4517214 179732 11 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 450 3 2 3 5.4 CC1=C(C(=O)Nc2ccccc2C)C(c2ccc(Br)cc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
3142523 181948 7 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 378 3 2 4 4.7 CC1=C(C(=O)Nc2ccccc2C)C(c2cccs2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4570341 181948 7 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 378 3 2 4 4.7 CC1=C(C(=O)Nc2ccccc2C)C(c2cccs2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155516418 176853 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 417 3 2 5 4.6 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2cocn2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4443263 176853 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 417 3 2 5 4.6 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2cocn2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155534383 178719 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 433 3 2 5 5.1 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2cncs2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4470404 178719 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 433 3 2 5 5.1 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2cncs2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
129743659 182324 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 372 3 2 3 4.6 CC1=C(C(=O)Nc2ccccc2C)C(c2ccccc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4578663 182324 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 372 3 2 3 4.6 CC1=C(C(=O)Nc2ccccc2C)C(c2ccccc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
91885415 181681 31 None -1 3 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 416 3 2 4 5.2 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4564389 181681 31 None -1 3 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 416 3 2 4 5.2 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155560774 181824 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 417 3 2 5 4.6 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2ncco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4567723 181824 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 417 3 2 5 4.6 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2ncco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155565387 182351 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 433 3 2 5 5.1 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2cscn2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4579352 182351 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 433 3 2 5 5.1 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2cscn2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155544770 181799 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 378 4 2 5 3.9 COc1ccccc1NC(=O)C1=C(C)NC2=C(C(=O)CCC2)C1c1ccco1 10.1021/acs.jmedchem.9b02036
CHEMBL4567192 181799 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 378 4 2 5 3.9 COc1ccccc1NC(=O)C1=C(C)NC2=C(C(=O)CCC2)C1c1ccco1 10.1021/acs.jmedchem.9b02036
155534079 178707 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 352 4 2 3 4.5 CC1=C(C(=O)Nc2ccccc2C)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4470184 178707 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 352 4 2 3 4.5 CC1=C(C(=O)Nc2ccccc2C)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155532033 178489 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 374 4 2 3 4.5 CC1=C(C(=O)Nc2c(F)cccc2F)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4466772 178489 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 374 4 2 3 4.5 CC1=C(C(=O)Nc2c(F)cccc2F)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
11646235 8418 16 None 1 3 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 362 3 2 4 4.2 CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 10.1021/acs.jmedchem.9b02036
12859 8418 16 None 1 3 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 362 3 2 4 4.2 CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 10.1021/acs.jmedchem.9b02036
CHEMBL4448591 8418 16 None 1 3 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 362 3 2 4 4.2 CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 10.1021/acs.jmedchem.9b02036
6500 6823 115 None 47 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 100 1 1 1 0.9 OC(=O)C1(C)CC1 10.1021/acs.jmedchem.9b02036
81326 6823 115 None 47 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 100 1 1 1 0.9 OC(=O)C1(C)CC1 10.1021/acs.jmedchem.9b02036
CHEMBL4516837 6823 115 None 47 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 100 1 1 1 0.9 OC(=O)C1(C)CC1 10.1021/acs.jmedchem.9b02036
155553285 180964 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 440 3 2 4 5.0 CC1=C(C(=O)Nc2ccccc2C)C(c2ccc(Br)o2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4547569 180964 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 440 3 2 4 5.0 CC1=C(C(=O)Nc2ccccc2C)C(c2ccc(Br)o2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155516172 176820 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 390 3 2 3 4.8 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(C2CC2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4442868 176820 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 390 3 2 3 4.8 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(C2CC2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155561259 182458 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 433 3 2 5 5.1 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2nccs2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4581781 182458 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 433 3 2 5 5.1 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2nccs2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155540222 179689 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 366 6 2 3 5.0 CCCCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
CHEMBL4516265 179689 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 366 6 2 3 5.0 CCCCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
155561832 182598 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 352 5 2 3 4.6 CCCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
CHEMBL4584743 182598 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 352 5 2 3 4.6 CCCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
155518116 177057 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 440 3 2 3 5.6 CC1=C(C(=O)Nc2ccccc2C)C(c2cccc(C(F)(F)F)c2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4446232 177057 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 440 3 2 3 5.6 CC1=C(C(=O)Nc2ccccc2C)C(c2cccc(C(F)(F)F)c2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155539179 179585 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 364 3 2 3 4.6 CC1=C(C(=O)Nc2ccccc2C)C(C2CCCC2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4513816 179585 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 364 3 2 3 4.6 CC1=C(C(=O)Nc2ccccc2C)C(C2CCCC2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
3142523 181948 7 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 378 3 2 4 4.7 CC1=C(C(=O)Nc2ccccc2C)C(c2cccs2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4570341 181948 7 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 378 3 2 4 4.7 CC1=C(C(=O)Nc2ccccc2C)C(c2cccs2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
3144722 177414 6 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 386 3 2 3 4.9 CC1=C(C(=O)Nc2ccccc2C)C(c2ccc(C)cc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4451216 177414 6 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 386 3 2 3 4.9 CC1=C(C(=O)Nc2ccccc2C)C(c2ccc(C)cc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
3142525 182132 11 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 450 3 2 3 5.4 CC1=C(C(=O)Nc2ccccc2C)C(c2cccc(Br)c2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4574477 182132 11 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 450 3 2 3 5.4 CC1=C(C(=O)Nc2ccccc2C)C(c2cccc(Br)c2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155528851 178166 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 376 4 2 4 4.6 CCC1=C(C(=O)Nc2ccccc2C)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4462079 178166 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 376 4 2 4 4.6 CCC1=C(C(=O)Nc2ccccc2C)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155536193 178929 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 324 3 2 3 3.8 CCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
CHEMBL4473184 178929 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 324 3 2 3 3.8 CCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
155514799 176672 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 348 3 2 4 3.9 CC1=C(C(=O)Nc2ccccc2)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4440699 176672 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 348 3 2 4 3.9 CC1=C(C(=O)Nc2ccccc2)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155540026 179268 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 375 3 2 4 3.9 CC1=C(C(=O)Nc2ccccc2C)C(c2cccn2C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4483052 179268 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 375 3 2 4 3.9 CC1=C(C(=O)Nc2ccccc2C)C(c2cccn2C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
3144722 177414 6 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 386 3 2 3 4.9 CC1=C(C(=O)Nc2ccccc2C)C(c2ccc(C)cc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4451216 177414 6 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 386 3 2 3 4.9 CC1=C(C(=O)Nc2ccccc2C)C(c2ccc(C)cc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155544770 181799 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 378 4 2 5 3.9 COc1ccccc1NC(=O)C1=C(C)NC2=C(C(=O)CCC2)C1c1ccco1 10.1021/acs.jmedchem.9b02036
CHEMBL4567192 181799 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 378 4 2 5 3.9 COc1ccccc1NC(=O)C1=C(C)NC2=C(C(=O)CCC2)C1c1ccco1 10.1021/acs.jmedchem.9b02036
3144726 179732 11 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 450 3 2 3 5.4 CC1=C(C(=O)Nc2ccccc2C)C(c2ccc(Br)cc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4517214 179732 11 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 450 3 2 3 5.4 CC1=C(C(=O)Nc2ccccc2C)C(c2ccc(Br)cc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155558623 181535 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 323 4 2 3 4.3 CC1=C(C#N)C(CC(C)C)C(C(=O)Nc2ccccc2C)=C(C)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4560915 181535 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 323 4 2 3 4.3 CC1=C(C#N)C(CC(C)C)C(C(=O)Nc2ccccc2C)=C(C)N1 10.1021/acs.jmedchem.9b02036
155522979 177561 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 372 4 2 3 4.8 CC1=C(C(=O)Nc2ccccc2Cl)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4452922 177561 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 372 4 2 3 4.8 CC1=C(C(=O)Nc2ccccc2Cl)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155558278 181532 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 464 4 2 3 4.8 CC1=C(C(=O)Nc2ccccc2I)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4560771 181532 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 464 4 2 3 4.8 CC1=C(C(=O)Nc2ccccc2I)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155540222 179689 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 366 6 2 3 5.0 CCCCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
CHEMBL4516265 179689 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 366 6 2 3 5.0 CCCCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
155536193 178929 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 324 3 2 3 3.8 CCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
CHEMBL4473184 178929 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 324 3 2 3 3.8 CCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
155534056 178716 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 362 3 2 4 4.2 CC1=C(C(=O)Nc2cccc(C)c2)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4470372 178716 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 362 3 2 4 4.2 CC1=C(C(=O)Nc2cccc(C)c2)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155516295 176854 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 398 4 2 3 5.1 CC1=C(C(=O)Nc2ccccc2C)C(/C=C/c2ccccc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4443269 176854 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 398 4 2 3 5.1 CC1=C(C(=O)Nc2ccccc2C)C(/C=C/c2ccccc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155536391 178926 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 440 3 2 3 5.6 CC1=C(C(=O)Nc2ccccc2C)C(c2ccc(C(F)(F)F)cc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4473169 178926 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 440 3 2 3 5.6 CC1=C(C(=O)Nc2ccccc2C)C(c2ccc(C(F)(F)F)cc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155519653 177142 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 352 4 2 3 4.5 CCC(C)C1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
CHEMBL4447610 177142 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 352 4 2 3 4.5 CCC(C)C1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
11646235 8418 16 None 1 3 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 362 3 2 4 4.2 CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 10.1021/acs.jmedchem.9b02036
12859 8418 16 None 1 3 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 362 3 2 4 4.2 CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 10.1021/acs.jmedchem.9b02036
CHEMBL4448591 8418 16 None 1 3 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 362 3 2 4 4.2 CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 10.1021/acs.jmedchem.9b02036
155534079 178707 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 352 4 2 3 4.5 CC1=C(C(=O)Nc2ccccc2C)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4470184 178707 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 352 4 2 3 4.5 CC1=C(C(=O)Nc2ccccc2C)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
11610220 181896 1 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 362 3 2 4 4.2 CC1=C(C(=O)Nc2ccccc2C)C(c2ccoc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4569482 181896 1 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 362 3 2 4 4.2 CC1=C(C(=O)Nc2ccccc2C)C(c2ccoc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
11646235 8418 16 None 1 3 Human 6.3 pEC50 = 6.3 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 362 3 2 4 4.2 CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 10.1021/acs.jmedchem.9b02036
12859 8418 16 None 1 3 Human 6.3 pEC50 = 6.3 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 362 3 2 4 4.2 CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 10.1021/acs.jmedchem.9b02036
CHEMBL4448591 8418 16 None 1 3 Human 6.3 pEC50 = 6.3 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 362 3 2 4 4.2 CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 10.1021/acs.jmedchem.9b02036
155553095 180885 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 362 3 2 4 4.2 CC1=C(C(=O)Nc2ccc(C)cc2)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4545039 180885 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 362 3 2 4 4.2 CC1=C(C(=O)Nc2ccc(C)cc2)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155518312 177052 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 366 4 2 3 4.8 CC1=C(C(=O)Nc2cccc(C)c2C)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4446176 177052 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 366 4 2 3 4.8 CC1=C(C(=O)Nc2cccc(C)c2C)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155551702 181920 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 378 3 2 3 5.0 CC1=C(C(=O)Nc2ccccc2C)C(C2CCCCC2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4569894 181920 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 378 3 2 3 5.0 CC1=C(C(=O)Nc2ccccc2C)C(C2CCCCC2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
11610220 181896 1 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 362 3 2 4 4.2 CC1=C(C(=O)Nc2ccccc2C)C(c2ccoc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4569482 181896 1 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 362 3 2 4 4.2 CC1=C(C(=O)Nc2ccccc2C)C(c2ccoc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155560731 181836 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 400 5 2 3 5.1 CC1=C(C(=O)Nc2ccccc2C)C(CCc2ccccc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4567938 181836 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 400 5 2 3 5.1 CC1=C(C(=O)Nc2ccccc2C)C(CCc2ccccc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155553549 180971 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 336 3 2 3 3.8 CC1=C(C(=O)Nc2ccccc2C)C(C2CC2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4547759 180971 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 336 3 2 3 3.8 CC1=C(C(=O)Nc2ccccc2C)C(C2CC2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155534708 178745 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 277 3 1 4 2.7 COC(=O)C1=C(C)NC2=C(C(=O)CCC2)C1CC(C)C 10.1021/acs.jmedchem.9b02036
CHEMBL4470725 178745 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 277 3 1 4 2.7 COC(=O)C1=C(C)NC2=C(C(=O)CCC2)C1CC(C)C 10.1021/acs.jmedchem.9b02036
155560731 181836 0 None - 1 Human 4.2 pEC50 = 4.2 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 400 5 2 3 5.1 CC1=C(C(=O)Nc2ccccc2C)C(CCc2ccccc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4567938 181836 0 None - 1 Human 4.2 pEC50 = 4.2 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 400 5 2 3 5.1 CC1=C(C(=O)Nc2ccccc2C)C(CCc2ccccc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155514597 176682 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 372 4 2 3 4.9 CCCC1C(C(=O)Nc2cc(C)ccc2Cl)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
CHEMBL4440835 176682 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 372 4 2 3 4.9 CCCC1C(C(=O)Nc2cc(C)ccc2Cl)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
3142521 181122 7 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 400 4 2 3 5.2 CCc1ccc(C2C(C(=O)Nc3ccccc3C)=C(C)NC3=C2C(=O)CCC3)cc1 10.1021/acs.jmedchem.9b02036
CHEMBL4551085 181122 7 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 400 4 2 3 5.2 CCc1ccc(C2C(C(=O)Nc3ccccc3C)=C(C)NC3=C2C(=O)CCC3)cc1 10.1021/acs.jmedchem.9b02036
155558278 181532 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 464 4 2 3 4.8 CC1=C(C(=O)Nc2ccccc2I)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4560771 181532 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 464 4 2 3 4.8 CC1=C(C(=O)Nc2ccccc2I)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155553095 180885 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 362 3 2 4 4.2 CC1=C(C(=O)Nc2ccc(C)cc2)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4545039 180885 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 362 3 2 4 4.2 CC1=C(C(=O)Nc2ccc(C)cc2)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155526048 177868 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 338 4 2 3 4.2 CCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
CHEMBL4457531 177868 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 338 4 2 3 4.2 CCCC1C(C(=O)Nc2ccccc2C)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
155539478 179637 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 356 5 2 4 3.9 COC(=O)C1=C(C)NC(C)=C(C(=O)Nc2ccccc2C)C1CC(C)C 10.1021/acs.jmedchem.9b02036
CHEMBL4515057 179637 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 356 5 2 4 3.9 COC(=O)C1=C(C)NC(C)=C(C(=O)Nc2ccccc2C)C1CC(C)C 10.1021/acs.jmedchem.9b02036
155522979 177561 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 372 4 2 3 4.8 CC1=C(C(=O)Nc2ccccc2Cl)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4452922 177561 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 372 4 2 3 4.8 CC1=C(C(=O)Nc2ccccc2Cl)C(CC(C)C)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155516295 176854 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 398 4 2 3 5.1 CC1=C(C(=O)Nc2ccccc2C)C(/C=C/c2ccccc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4443269 176854 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Positive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assayPositive allosteric modulation at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr in presence of 1 uM propionate by fluorescence plate reader assay
ChEMBL 398 4 2 3 5.1 CC1=C(C(=O)Nc2ccccc2C)C(/C=C/c2ccccc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155536391 178926 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 440 3 2 3 5.6 CC1=C(C(=O)Nc2ccccc2C)C(c2ccc(C(F)(F)F)cc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4473169 178926 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 440 3 2 3 5.6 CC1=C(C(=O)Nc2ccccc2C)C(c2ccc(C(F)(F)F)cc2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155514799 176672 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 348 3 2 4 3.9 CC1=C(C(=O)Nc2ccccc2)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4440699 176672 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 348 3 2 4 3.9 CC1=C(C(=O)Nc2ccccc2)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
155538420 179158 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 428 3 2 4 5.8 CC1=C(C(=O)Nc2ccccc2C)C(c2csc3ccccc23)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4476349 179158 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 428 3 2 4 5.8 CC1=C(C(=O)Nc2ccccc2C)C(c2csc3ccccc23)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
3142521 181122 7 None - 1 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 400 4 2 3 5.2 CCc1ccc(C2C(C(=O)Nc3ccccc3C)=C(C)NC3=C2C(=O)CCC3)cc1 10.1021/acs.jmedchem.9b02036
CHEMBL4551085 181122 7 None - 1 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometryAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cell membrane assessed as stimulation of [35S]-GTPgammaS binding measured after 1 hr in presence of GDP by liquid scintillation spectrometry
ChEMBL 400 4 2 3 5.2 CCc1ccc(C2C(C(=O)Nc3ccccc3C)=C(C)NC3=C2C(=O)CCC3)cc1 10.1021/acs.jmedchem.9b02036
155569134 182922 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 358 4 2 3 4.6 CCCC1C(C(=O)Nc2ccccc2Cl)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
CHEMBL4592426 182922 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assayAgonist activity at human FFA3 receptor stably expressed in Flp-In T-Rex HEK293 cells cotransfected with eYFP assessed as inhibition of forskolin-induced cAMP production measured after 1 hr by fluorescence plate reader assay
ChEMBL 358 4 2 3 4.6 CCCC1C(C(=O)Nc2ccccc2Cl)=C(C)NC2=C1C(=O)CCC2 10.1021/acs.jmedchem.9b02036
1058 7042 85 None -3 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
Drug Central 60 0 1 1 0.1 CC(=O)O None
176 7042 85 None -3 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
Drug Central 60 0 1 1 0.1 CC(=O)O None
21980959 7042 85 None -3 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
Drug Central 60 0 1 1 0.1 CC(=O)O None
4211 7042 85 None -3 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
Drug Central 60 0 1 1 0.1 CC(=O)O None
CHEMBL539 7042 85 None -3 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
Drug Central 60 0 1 1 0.1 CC(=O)O None
DB03166 7042 85 None -3 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting methodAgonist activity at human GPCR41 transfected in HEK293 cells assessed as [35S]GTPgammaS binding by scintillation counting method
Drug Central 60 0 1 1 0.1 CC(=O)O None
1058 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12496283
1058 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12711604
1058 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 14722361
1058 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 21220428
176 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12496283
176 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12711604
176 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 14722361
176 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 21220428
21980959 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12496283
21980959 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12711604
21980959 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 14722361
21980959 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 21220428
4211 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12496283
4211 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12711604
4211 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 14722361
4211 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 21220428
CHEMBL539 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12496283
CHEMBL539 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12711604
CHEMBL539 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 14722361
CHEMBL539 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 21220428
DB03166 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12496283
DB03166 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 12711604
DB03166 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 14722361
DB03166 7042 85 None -3 2 Human 3.4 pEC50 = 3.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 60 0 1 1 0.1 CC(=O)O 21220428
6500 6823 115 None 47 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 100 1 1 1 0.9 OC(=O)C1(C)CC1 21220428
81326 6823 115 None 47 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 100 1 1 1 0.9 OC(=O)C1(C)CC1 21220428
CHEMBL4516837 6823 115 None 47 2 Human 3.9 pEC50 = 3.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 100 1 1 1 0.9 OC(=O)C1(C)CC1 21220428
1059 7537 81 None 7 3 Human 4.4 pEC50 = 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12496283
1059 7537 81 None 7 3 Human 4.4 pEC50 = 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12711604
1059 7537 81 None 7 3 Human 4.4 pEC50 = 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 14722361
1059 7537 81 None 7 3 Human 4.4 pEC50 = 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 21220428
264 7537 81 None 7 3 Human 4.4 pEC50 = 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12496283
264 7537 81 None 7 3 Human 4.4 pEC50 = 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12711604
264 7537 81 None 7 3 Human 4.4 pEC50 = 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 14722361
264 7537 81 None 7 3 Human 4.4 pEC50 = 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 21220428
CHEMBL14227 7537 81 None 7 3 Human 4.4 pEC50 = 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12496283
CHEMBL14227 7537 81 None 7 3 Human 4.4 pEC50 = 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12711604
CHEMBL14227 7537 81 None 7 3 Human 4.4 pEC50 = 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 14722361
CHEMBL14227 7537 81 None 7 3 Human 4.4 pEC50 = 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 21220428
DB03568 7537 81 None 7 3 Human 4.4 pEC50 = 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12496283
DB03568 7537 81 None 7 3 Human 4.4 pEC50 = 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 12711604
DB03568 7537 81 None 7 3 Human 4.4 pEC50 = 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 14722361
DB03568 7537 81 None 7 3 Human 4.4 pEC50 = 4.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 2 1 1 0.9 CCCC(=O)O 21220428
1061 9818 0 None 50 2 Human 4.6 pEC50 = 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 102 3 1 1 1.3 CCCCC(=O)O 12496283
1061 9818 0 None 50 2 Human 4.6 pEC50 = 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 102 3 1 1 1.3 CCCCC(=O)O 14722361
7991 9818 0 None 50 2 Human 4.6 pEC50 = 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 102 3 1 1 1.3 CCCCC(=O)O 12496283
7991 9818 0 None 50 2 Human 4.6 pEC50 = 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 102 3 1 1 1.3 CCCCC(=O)O 14722361
CHEMBL268736 9818 0 None 50 2 Human 4.6 pEC50 = 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 102 3 1 1 1.3 CCCCC(=O)O 12496283
CHEMBL268736 9818 0 None 50 2 Human 4.6 pEC50 = 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 102 3 1 1 1.3 CCCCC(=O)O 14722361
DB02406 9818 0 None 50 2 Human 4.6 pEC50 = 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 102 3 1 1 1.3 CCCCC(=O)O 12496283
DB02406 9818 0 None 50 2 Human 4.6 pEC50 = 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 102 3 1 1 1.3 CCCCC(=O)O 14722361
1032 9959 78 None 8 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12496283
1032 9959 78 None 8 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12711604
1032 9959 78 None 8 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 14722361
1032 9959 78 None 8 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 21220428
1062 9959 78 None 8 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12496283
1062 9959 78 None 8 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12711604
1062 9959 78 None 8 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 14722361
1062 9959 78 None 8 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 21220428
CHEMBL14021 9959 78 None 8 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12496283
CHEMBL14021 9959 78 None 8 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12711604
CHEMBL14021 9959 78 None 8 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 14722361
CHEMBL14021 9959 78 None 8 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 21220428
DB03766 9959 78 None 8 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12496283
DB03766 9959 78 None 8 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 12711604
DB03766 9959 78 None 8 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 14722361
DB03766 9959 78 None 8 2 Human 4.8 pEC50 = 4.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 74 1 1 1 0.5 CCC(=O)O 21220428
11646235 8418 16 None 1 3 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 362 3 2 4 4.2 CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 24870406
12859 8418 16 None 1 3 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 362 3 2 4 4.2 CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 24870406
CHEMBL4448591 8418 16 None 1 3 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 362 3 2 4 4.2 CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 24870406
1060 8870 74 None 1 3 Human 4.6 pEC50 None 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 1 1 1 0.7 CC(C(=O)O)C 12496283
1060 8870 74 None 1 3 Human 4.6 pEC50 None 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 1 1 1 0.7 CC(C(=O)O)C 14722361
6590 8870 74 None 1 3 Human 4.6 pEC50 None 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 1 1 1 0.7 CC(C(=O)O)C 12496283
6590 8870 74 None 1 3 Human 4.6 pEC50 None 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 1 1 1 0.7 CC(C(=O)O)C 14722361
CHEMBL108778 8870 74 None 1 3 Human 4.6 pEC50 None 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 1 1 1 0.7 CC(C(=O)O)C 12496283
CHEMBL108778 8870 74 None 1 3 Human 4.6 pEC50 None 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 1 1 1 0.7 CC(C(=O)O)C 14722361
DB02531 8870 74 None 1 3 Human 4.6 pEC50 None 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 1 1 1 0.7 CC(C(=O)O)C 12496283
DB02531 8870 74 None 1 3 Human 4.6 pEC50 None 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 88 1 1 1 0.7 CC(C(=O)O)C 14722361




Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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DOI

23681741 153665 11 None - 0 Rat 4.0 pEC50 = 4 Binding
Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay
ChEMBL 168 5 0 2 -2.3 CCCCCCC(=O)[O-].[K+] nan
CHEMBL3925414 153665 11 None - 0 Rat 4.0 pEC50 = 4 Binding
Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay
ChEMBL 168 5 0 2 -2.3 CCCCCCC(=O)[O-].[K+] nan
155546001 180284 0 None - 0 Mouse 6.0 pEC50 = 6.0 Binding
Agonist activity at mouse FFA3 receptorAgonist activity at mouse FFA3 receptor
ChEMBL 418 3 2 3 5.6 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(C2CCCC2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4530642 180284 0 None - 0 Mouse 6.0 pEC50 = 6.0 Binding
Agonist activity at mouse FFA3 receptorAgonist activity at mouse FFA3 receptor
ChEMBL 418 3 2 3 5.6 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(C2CCCC2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
91885415 181681 31 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at mouse FFA3 receptorAgonist activity at mouse FFA3 receptor
ChEMBL 416 3 2 4 5.2 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4564389 181681 31 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at mouse FFA3 receptorAgonist activity at mouse FFA3 receptor
ChEMBL 416 3 2 4 5.2 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
11646235 8418 16 None - 0 Rat 5.9 pEC50 = 5.9 Binding
Agonist activity at rat FFA3 receptorAgonist activity at rat FFA3 receptor
ChEMBL 362 3 2 4 4.2 CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 10.1021/acs.jmedchem.9b02036
12859 8418 16 None - 0 Rat 5.9 pEC50 = 5.9 Binding
Agonist activity at rat FFA3 receptorAgonist activity at rat FFA3 receptor
ChEMBL 362 3 2 4 4.2 CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 10.1021/acs.jmedchem.9b02036
CHEMBL4448591 8418 16 None - 0 Rat 5.9 pEC50 = 5.9 Binding
Agonist activity at rat FFA3 receptorAgonist activity at rat FFA3 receptor
ChEMBL 362 3 2 4 4.2 CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 10.1021/acs.jmedchem.9b02036
53322689 64834 1 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay
ChEMBL 224 1 2 5 0.7 CCc1cc(=O)oc2nc(S)[nH]c(=O)c12 10.1039/d2md00076h
CHEMBL1672755 64834 1 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay
ChEMBL 224 1 2 5 0.7 CCc1cc(=O)oc2nc(S)[nH]c(=O)c12 10.1039/d2md00076h
15605571 82010 2 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay
ChEMBL 236 3 2 4 0.5 CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12 10.1039/d2md00076h
CHEMBL2036813 82010 2 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay
ChEMBL 236 3 2 4 0.5 CCCCc1cc(=O)oc2[nH]c(=O)[nH]c(=O)c12 10.1039/d2md00076h
CHEMBL5270112 200399 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay
ChEMBL 252 3 2 4 1.9 CCCCc1cc(=O)oc2[nH]c(=S)[nH]c(=O)c12 10.1039/d2md00076h
CHEMBL5275861 200651 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay
ChEMBL 286 4 2 4 2.1 O=c1cc(CCCCCl)c2c(=O)[nH]c(=S)[nH]c2o1 10.1039/d2md00076h
CHEMBL5277000 200700 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay
ChEMBL 238 2 2 4 1.5 CCCc1cc(=O)oc2[nH]c(=S)[nH]c(=O)c12 10.1039/d2md00076h
CHEMBL5281556 200895 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay
ChEMBL 210 0 2 4 0.8 Cc1cc(=O)oc2[nH]c(=S)[nH]c(=O)c12 10.1039/d2md00076h
CHEMBL5284951 201052 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assayAgonist activity at FFA3 (unknown origin) expressed in human Flp-In-293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Lance cAMP assay
ChEMBL 270 4 2 4 0.7 O=c1[nH]c(=O)c2c(CCCCCl)cc(=O)oc2[nH]1 10.1039/d2md00076h
23668516 114321 15 None - 0 Rat 5.5 pEC50 = 5.5 Binding
Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay
ChEMBL 140 3 0 2 -3.1 CCCCC(=O)[O-].[K+] nan
CHEMBL3188068 114321 15 None - 0 Rat 5.5 pEC50 = 5.5 Binding
Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay
ChEMBL 140 3 0 2 -3.1 CCCCC(=O)[O-].[K+] nan
1060 8870 74 None - 0 Rat 4.5 pEC50 = 4.5 Binding
Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay
ChEMBL 88 1 1 1 0.7 CC(C(=O)O)C nan
6590 8870 74 None - 0 Rat 4.5 pEC50 = 4.5 Binding
Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay
ChEMBL 88 1 1 1 0.7 CC(C(=O)O)C nan
CHEMBL108778 8870 74 None - 0 Rat 4.5 pEC50 = 4.5 Binding
Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay
ChEMBL 88 1 1 1 0.7 CC(C(=O)O)C nan
DB02531 8870 74 None - 0 Rat 4.5 pEC50 = 4.5 Binding
Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay
ChEMBL 88 1 1 1 0.7 CC(C(=O)O)C nan
61138 114273 107 None - 0 Rat 4.5 pEC50 = 4.5 Binding
Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay
ChEMBL 100 3 1 1 1.0 C=CCCC(=O)O nan
CHEMBL3185583 114273 107 None - 0 Rat 4.5 pEC50 = 4.5 Binding
Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay
ChEMBL 100 3 1 1 1.0 C=CCCC(=O)O nan
23670380 152108 10 None - 0 Rat 4.5 pEC50 = 4.5 Binding
Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay
ChEMBL 154 4 0 2 -2.7 CCCCCC(=O)[O-].[K+] nan
CHEMBL3913375 152108 10 None - 0 Rat 4.5 pEC50 = 4.5 Binding
Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay
ChEMBL 154 4 0 2 -2.7 CCCCCC(=O)[O-].[K+] nan
11646235 8418 16 None - 0 Mouse 5.4 pEC50 = 5.4 Binding
Agonist activity at mouse FFA3 receptorAgonist activity at mouse FFA3 receptor
ChEMBL 362 3 2 4 4.2 CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 10.1021/acs.jmedchem.9b02036
12859 8418 16 None - 0 Mouse 5.4 pEC50 = 5.4 Binding
Agonist activity at mouse FFA3 receptorAgonist activity at mouse FFA3 receptor
ChEMBL 362 3 2 4 4.2 CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 10.1021/acs.jmedchem.9b02036
CHEMBL4448591 8418 16 None - 0 Mouse 5.4 pEC50 = 5.4 Binding
Agonist activity at mouse FFA3 receptorAgonist activity at mouse FFA3 receptor
ChEMBL 362 3 2 4 4.2 CC1=C(C(C2=CC=CO2)C3=C(CCCC3=O)N1)C(=O)NC4=C(C)C=CC=C4 10.1021/acs.jmedchem.9b02036
155546001 180284 0 None - 0 Rat 6.4 pEC50 = 6.4 Binding
Agonist activity at rat FFA3 receptorAgonist activity at rat FFA3 receptor
ChEMBL 418 3 2 3 5.6 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(C2CCCC2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4530642 180284 0 None - 0 Rat 6.4 pEC50 = 6.4 Binding
Agonist activity at rat FFA3 receptorAgonist activity at rat FFA3 receptor
ChEMBL 418 3 2 3 5.6 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(C2CCCC2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
91885415 181681 31 None - 0 Rat 6.3 pEC50 = 6.3 Binding
Agonist activity at rat FFA3 receptorAgonist activity at rat FFA3 receptor
ChEMBL 416 3 2 4 5.2 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
CHEMBL4564389 181681 31 None - 0 Rat 6.3 pEC50 = 6.3 Binding
Agonist activity at rat FFA3 receptorAgonist activity at rat FFA3 receptor
ChEMBL 416 3 2 4 5.2 CC1=C(C(=O)Nc2cc(Cl)ccc2Cl)C(c2ccco2)C2=C(CCCC2=O)N1 10.1021/acs.jmedchem.9b02036
2723816 195114 74 None - 0 Rat 5.3 pEC50 = 5.3 Binding
Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay
ChEMBL 96 1 0 2 -3.9 CCC(=O)[O-].[Na+] nan
CHEMBL500826 195114 74 None - 0 Rat 5.3 pEC50 = 5.3 Binding
Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay
ChEMBL 96 1 0 2 -3.9 CCC(=O)[O-].[Na+] nan
23677461 149260 10 None - 0 Rat 4.3 pEC50 = 4.3 Binding
Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay
ChEMBL 126 2 0 2 -3.5 CCCC(=O)[O-].[K+] nan
CHEMBL3890404 149260 10 None - 0 Rat 4.3 pEC50 = 4.3 Binding
Agonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assayAgonist activity at rat GPR41 expressed in Saccharomyces cerevisiae MMY22 co-expressing chimeric Gpa1/Galpha0 by induction of FUSl-lacZ and FUS1-HIS3 reporter gene induction based pheromone response pathway coupled assay
ChEMBL 126 2 0 2 -3.5 CCCC(=O)[O-].[K+] nan