Ligand source activities (1 row/activity)





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DOI

10069786 175880 0 None -147 3 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 404 7 1 3 5.3 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL439968 175880 0 None -147 3 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 404 7 1 3 5.3 CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
2541 7573 120 None -8128 10 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acsmedchemlett.1c00240
587 7573 120 None -8128 10 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acsmedchemlett.1c00240
6907 7573 120 None -8128 10 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acsmedchemlett.1c00240
CHEMBL1016 7573 120 None -8128 10 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acsmedchemlett.1c00240
DB00796 7573 120 None -8128 10 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acsmedchemlett.1c00240
DB13919 7573 120 None -8128 10 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 440 7 2 7 4.0 CCOc1nc2c(n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)c(ccc2)C(=O)O 10.1021/acsmedchemlett.1c00240
2806 10741 110 None -5623 4 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/acsmedchemlett.1c00240
3937 10741 110 None -5623 4 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/acsmedchemlett.1c00240
593 10741 110 None -5623 4 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/acsmedchemlett.1c00240
60846 10741 110 None -5623 4 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/acsmedchemlett.1c00240
CHEMBL1069 10741 110 None -5623 4 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/acsmedchemlett.1c00240
DB00177 10741 110 None -5623 4 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 435 10 2 5 4.2 CCCCC(=O)N([C@H](C(=O)O)C(C)C)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1 10.1021/acsmedchemlett.1c00240
44341650 176666 0 None -7 3 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 406 7 2 3 4.8 CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL444060 176666 0 None -7 3 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 406 7 2 3 4.8 CCCCC1NC(=O)C2(CCCC2)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
1481 8847 116 None -457 6 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
3749 8847 116 None -457 6 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
589 8847 116 None -457 6 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
6908 8847 116 None -457 6 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
CHEMBL1513 8847 116 None -457 6 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
DB01029 8847 116 None -457 6 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 428 7 1 5 4.8 CCCCC1=NC2(C(=O)N1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CCCC2 10.1021/acsmedchemlett.1c00240
164613537 191905 0 None -21 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 464 8 1 5 5.4 CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL4856425 191905 0 None -21 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 464 8 1 5 5.4 CCCCC1=NC(C)(c2ccccc2)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
164616479 192095 0 None -16 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 404 7 2 5 3.8 CCCCC1NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL4859498 192095 0 None -16 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 404 7 2 5 3.8 CCCCC1NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
44341785 16919 0 None -2 3 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 438 6 1 3 5.3 O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL115771 16919 0 None -2 3 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 438 6 1 3 5.3 O=C(O)c1ccccc1-c1ccc(CN2C(=O)C3(CCCC3)N=C2Cc2ccccc2)cc1 10.1021/acsmedchemlett.1c00240
67903280 192981 0 None -4 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 430 8 1 5 4.9 CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL4872989 192981 0 None -4 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 430 8 1 5 4.9 CCCCC1=NC(C)(C(C)C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
164611301 191797 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 416 7 1 5 3.9 CCCC[C@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@H]2CCCN21 10.1021/acsmedchemlett.1c00240
CHEMBL4854916 191797 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 416 7 1 5 3.9 CCCC[C@H]1N(Cc2ccc(-c3ccccc3-c3nnn[nH]3)cc2)C(=O)[C@H]2CCCN21 10.1021/acsmedchemlett.1c00240
67903275 193302 5 None -257 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 402 7 1 5 4.2 CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL4877651 193302 5 None -257 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 402 7 1 5 4.2 CCCCC1=NC(C)(C)C(=O)N1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1 10.1021/acsmedchemlett.1c00240
44342039 17065 0 None -117 3 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 418 7 1 3 5.7 CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
CHEMBL116170 17065 0 None -117 3 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assayAgonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay
ChEMBL 418 7 1 3 5.7 CCCCC1=NC2(CCCCC2)C(=O)N1Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acsmedchemlett.1c00240
25174150 15889 0 None -64 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099326 15889 0 None -64 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O 10.1021/jm1001919
25192022 10128 7 None -21 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
6158 10128 7 None -21 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
CHEMBL1098560 10128 7 None -21 2 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
25192471 15305 0 None -15 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094348 15305 0 None -15 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
23501721 15893 0 None -316 2 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 581 18 2 5 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099330 15893 0 None -316 2 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 581 18 2 5 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O 10.1021/jm1001919
25192021 15886 0 None -223 2 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 580 18 2 4 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099323 15886 0 None -223 2 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT2 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 580 18 2 4 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O 10.1021/jm1001919
2487 9147 36 None -7 2 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 18378794
5280492 9147 36 None -7 2 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 18378794
CHEMBL65061 9147 36 None -7 2 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 18378794
DB12961 9147 36 None -7 2 Human 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 18378794
51529932 7599 28 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 8 1 2 5.8 CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O 15866883
6161 7599 28 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 8 1 2 5.8 CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O 15866883
CHEMBL4637519 7599 28 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 387 8 1 2 5.8 CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O 15866883
5283141 6799 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 280 12 2 2 4.2 CCCCC[C@@H](/C=C/C=C/C/C=C\CCCC(=O)O)O 18378794
6159 6799 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 280 12 2 2 4.2 CCCCC[C@@H](/C=C/C=C/C/C=C\CCCC(=O)O)O 18378794
6155 7959 0 None -1318 2 Human 5.0 pEC50 > 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 11278893
9823886 7959 0 None -1318 2 Human 5.0 pEC50 > 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 11278893
CHEMBL301829 7959 0 None -1318 2 Human 5.0 pEC50 > 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 11278893
DB13053 7959 0 None -1318 2 Human 5.0 pEC50 > 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 11278893
5283130 6798 0 None - 1 Human 7.5 pEC50 > 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 11278893
6160 6798 0 None - 1 Human 7.5 pEC50 > 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 11278893
CHEMBL1742496 6798 0 None - 1 Human 7.5 pEC50 > 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 11278893
3404 6801 29 None -107 3 Human 7.5 pEC50 > 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 11278893
5283155 6801 29 None -107 3 Human 7.5 pEC50 > 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 11278893
5508 6801 29 None -107 3 Human 7.5 pEC50 > 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 11278893
CHEMBL1526258 6801 29 None -107 3 Human 7.5 pEC50 > 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 11278893
3401 6812 0 None - 1 Human 7.5 pEC50 > 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC[C@@H](/C=C/C=C\C/C=C\C/C=C\CCCC(=O)O)O 11278893
5280724 6812 0 None - 1 Human 7.5 pEC50 > 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC[C@@H](/C=C/C=C\C/C=C\C/C=C\CCCC(=O)O)O 11278893
CHEMBL594621 6812 0 None - 1 Human 7.5 pEC50 > 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC[C@@H](/C=C/C=C\C/C=C\C/C=C\CCCC(=O)O)O 11278893
6155 7959 0 None -1318 2 Human 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 11278893
9823886 7959 0 None -1318 2 Human 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 11278893
CHEMBL301829 7959 0 None -1318 2 Human 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 11278893
DB13053 7959 0 None -1318 2 Human 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 11278893
6162 10918 0 None - 1 Human 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 432 9 2 2 6.4 OC(=O)CCC/C=C/1\CCCCC1/C=C/C=C/C(C1(CCC1)CC#Cc1ccccc1)O 11278893
9824142 10918 0 None - 1 Human 6.0 pIC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 432 9 2 2 6.4 OC(=O)CCC/C=C/1\CCCCC1/C=C/C=C/C(C1(CCC1)CC#Cc1ccccc1)O 11278893
3351 9181 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 360 10 2 6 3.6 CCc1c(OCCCCCC(c2nnn[nH]2)(C)C)cc(cc1C(=O)C)O 11278893
3351 9181 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 360 10 2 6 3.6 CCc1c(OCCCCCC(c2nnn[nH]2)(C)C)cc(cc1C(=O)C)O 1316967
35025716 9181 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 360 10 2 6 3.6 CCc1c(OCCCCCC(c2nnn[nH]2)(C)C)cc(cc1C(=O)C)O 11278893
35025716 9181 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 360 10 2 6 3.6 CCc1c(OCCCCCC(c2nnn[nH]2)(C)C)cc(cc1C(=O)C)O 1316967
2487 9147 36 None -7 2 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 18378794
5280492 9147 36 None -7 2 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 18378794
CHEMBL65061 9147 36 None -7 2 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 18378794
DB12961 9147 36 None -7 2 Human 7.6 pIC50 = 7.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 18378794
5283141 6799 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 280 12 2 2 4.2 CCCCC[C@@H](/C=C/C=C/C/C=C\CCCC(=O)O)O 18378794
6159 6799 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology 280 12 2 2 4.2 CCCCC[C@@H](/C=C/C=C/C/C=C\CCCC(=O)O)O 18378794




Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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DOI

162655235 187487 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 385 7 1 2 5.4 O=C(O)c1ccccc1-c1ccc(CN(C(=O)CC2CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.0c00588
CHEMBL4755611 187487 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 385 7 1 2 5.4 O=C(O)c1ccccc1-c1ccc(CN(C(=O)CC2CC2)c2ccccc2)cc1 10.1021/acs.jmedchem.0c00588
162656403 187614 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 412 8 1 3 5.6 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(C#N)cc1 10.1021/acs.jmedchem.0c00588
CHEMBL4757022 187614 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 412 8 1 3 5.6 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(C#N)cc1 10.1021/acs.jmedchem.0c00588
162668994 189386 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 388 8 1 3 5.2 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccncc1 10.1021/acs.jmedchem.0c00588
CHEMBL4788291 189386 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 388 8 1 3 5.2 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccncc1 10.1021/acs.jmedchem.0c00588
162673156 189826 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 386 8 1 2 5.2 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(N)=O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4794074 189826 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 386 8 1 2 5.2 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(N)=O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
162666244 189139 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 464 9 1 4 4.8 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)NS(C)(=O)=O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4784810 189139 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 464 9 1 4 4.8 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)NS(C)(=O)=O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
162648208 186696 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 387 8 1 2 5.5 CCCCN(Cc1ccc(-c2ccccc2C(=O)O)cc1)C(=O)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4746093 186696 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 387 8 1 2 5.5 CCCCN(Cc1ccc(-c2ccccc2C(=O)O)cc1)C(=O)c1ccccc1 10.1021/acs.jmedchem.0c00588
162660119 188042 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 405 8 1 2 5.9 CCCCC(=O)N(Cc1ccc(-c2cc(F)ccc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4761937 188042 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 405 8 1 2 5.9 CCCCC(=O)N(Cc1ccc(-c2cc(F)ccc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
162650943 187059 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 417 9 1 3 5.8 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(OC)cc1 10.1021/acs.jmedchem.0c00588
CHEMBL4750707 187059 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 417 9 1 3 5.8 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(OC)cc1 10.1021/acs.jmedchem.0c00588
126508826 189505 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 411 8 1 4 5.3 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4789730 189505 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 411 8 1 4 5.3 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
162649472 186856 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 345 5 1 2 4.6 CC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4748013 186856 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 345 5 1 2 4.6 CC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
162644087 188549 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 447 7 1 4 5.4 CC(C)CC(=O)N(Cc1ccc(-c2cc(F)ccc2-c2nnn[nH]2)cc1)c1ccc(F)cc1 10.1021/acs.jmedchem.0c00588
CHEMBL4777675 188549 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 447 7 1 4 5.4 CC(C)CC(=O)N(Cc1ccc(-c2cc(F)ccc2-c2nnn[nH]2)cc1)c1ccc(F)cc1 10.1021/acs.jmedchem.0c00588
162654469 187361 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 401 8 1 2 6.1 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(C)cc1 10.1021/acs.jmedchem.0c00588
CHEMBL4754213 187361 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 401 8 1 2 6.1 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(C)cc1 10.1021/acs.jmedchem.0c00588
59738470 186725 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 401 9 1 2 5.8 CCCCC(=O)N(Cc1ccccc1)Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acs.jmedchem.0c00588
CHEMBL4746397 186725 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 401 9 1 2 5.8 CCCCC(=O)N(Cc1ccccc1)Cc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acs.jmedchem.0c00588
162670341 189756 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 405 8 1 2 5.9 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(F)cc1 10.1021/acs.jmedchem.0c00588
CHEMBL4793225 189756 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 405 8 1 2 5.9 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(F)cc1 10.1021/acs.jmedchem.0c00588
51529932 7599 28 None -4 2 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 387 8 1 2 5.8 CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O 10.1021/acs.jmedchem.0c00588
6161 7599 28 None -4 2 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 387 8 1 2 5.8 CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O 10.1021/acs.jmedchem.0c00588
CHEMBL4637519 7599 28 None -4 2 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 387 8 1 2 5.8 CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O 10.1021/acs.jmedchem.0c00588
162672880 189885 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 393 8 1 2 5.9 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)C1CCCCC1 10.1021/acs.jmedchem.0c00588
CHEMBL4794649 189885 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 393 8 1 2 5.9 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)C1CCCCC1 10.1021/acs.jmedchem.0c00588
162669252 189389 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 389 8 1 3 4.6 COCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4788324 189389 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 389 8 1 3 4.6 COCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
162648232 186535 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 388 8 1 3 5.2 CCCCC(=O)N(Cc1ccc(-c2cnccc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4744319 186535 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 388 8 1 3 5.2 CCCCC(=O)N(Cc1ccc(-c2cnccc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
162657757 187807 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 387 7 1 2 5.6 CC(C)CC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4759277 187807 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 387 7 1 2 5.6 CC(C)CC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
162646830 186390 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 421 7 1 2 5.8 O=C(O)c1ccccc1-c1ccc(CN(C(=O)Cc2ccccc2)c2ccccc2)cc1 10.1021/acs.jmedchem.0c00588
CHEMBL4742371 186390 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 421 7 1 2 5.8 O=C(O)c1ccccc1-c1ccc(CN(C(=O)Cc2ccccc2)c2ccccc2)cc1 10.1021/acs.jmedchem.0c00588
162665828 189167 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 359 6 1 2 5.0 CCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4785290 189167 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 359 6 1 2 5.0 CCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
162647867 186668 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 373 6 1 2 5.2 CC(C)C(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4745803 186668 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 373 6 1 2 5.2 CC(C)C(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
162646206 186252 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 415 10 1 2 5.8 CCCCN(Cc1ccc(-c2ccccc2C(=O)O)cc1)C(=O)CCc1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4740860 186252 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 415 10 1 2 5.8 CCCCN(Cc1ccc(-c2ccccc2C(=O)O)cc1)C(=O)CCc1ccccc1 10.1021/acs.jmedchem.0c00588
162653821 187265 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 373 7 1 2 5.4 CCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4753057 187265 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 373 7 1 2 5.4 CCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
162670478 189699 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 373 8 1 2 5.6 CCCCC(=O)N(Cc1ccc(-c2ccccc2CO)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4792472 189699 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 373 8 1 2 5.6 CCCCC(=O)N(Cc1ccc(-c2ccccc2CO)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
162649840 186902 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 421 8 1 2 6.4 CCCCC(=O)N(Cc1ccc(-c2ccc(Cl)cc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4748657 186902 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 421 8 1 2 6.4 CCCCC(=O)N(Cc1ccc(-c2ccc(Cl)cc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
162653410 187226 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 421 8 1 2 6.4 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(Cl)cc1 10.1021/acs.jmedchem.0c00588
CHEMBL4752602 187226 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 421 8 1 2 6.4 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(Cl)cc1 10.1021/acs.jmedchem.0c00588
162662368 188824 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 427 8 1 4 5.4 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4781057 188824 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 427 8 1 4 5.4 CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2noc(=O)[nH]2)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
162667186 189190 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 405 8 1 2 5.9 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1F)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4785658 189190 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 405 8 1 2 5.9 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1F)c1ccccc1 10.1021/acs.jmedchem.0c00588
162655314 187489 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 423 8 1 2 6.1 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(F)c(F)c1 10.1021/acs.jmedchem.0c00588
CHEMBL4755616 187489 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 423 8 1 2 6.1 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(F)c(F)c1 10.1021/acs.jmedchem.0c00588
71254998 188620 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 405 8 1 2 5.9 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1cccc(F)c1 10.1021/acs.jmedchem.0c00588
CHEMBL4778464 188620 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 405 8 1 2 5.9 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1cccc(F)c1 10.1021/acs.jmedchem.0c00588
162653581 187329 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 407 6 1 2 5.9 O=C(O)c1ccccc1-c1ccc(CN(C(=O)c2ccccc2)c2ccccc2)cc1 10.1021/acs.jmedchem.0c00588
CHEMBL4753841 187329 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 407 6 1 2 5.9 O=C(O)c1ccccc1-c1ccc(CN(C(=O)c2ccccc2)c2ccccc2)cc1 10.1021/acs.jmedchem.0c00588
118432349 186653 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 401 8 0 3 5.9 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)OC)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4745616 186653 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 401 8 0 3 5.9 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)OC)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
162647815 186611 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 405 8 1 2 5.9 CCCCC(=O)N(Cc1ccc(-c2ccc(F)cc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4745083 186611 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 405 8 1 2 5.9 CCCCC(=O)N(Cc1ccc(-c2ccc(F)cc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
162642938 188514 0 None - 0 Human 5.2 pEC50 = 5.2 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 353 8 1 2 5.0 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)C(C)C 10.1021/acs.jmedchem.0c00588
CHEMBL4777189 188514 0 None - 0 Human 5.2 pEC50 = 5.2 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 353 8 1 2 5.0 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)C(C)C 10.1021/acs.jmedchem.0c00588
144527428 187664 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 311 7 2 2 3.9 CCCCC(=O)NCc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acs.jmedchem.0c00588
CHEMBL4757499 187664 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 311 7 2 2 3.9 CCCCC(=O)NCc1ccc(-c2ccccc2C(=O)O)cc1 10.1021/acs.jmedchem.0c00588
162649935 186772 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 421 8 1 2 6.4 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1cccc(Cl)c1 10.1021/acs.jmedchem.0c00588
CHEMBL4746980 186772 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 421 8 1 2 6.4 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1cccc(Cl)c1 10.1021/acs.jmedchem.0c00588
162650402 186872 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 403 8 2 3 5.5 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(O)cc1 10.1021/acs.jmedchem.0c00588
CHEMBL4748248 186872 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 403 8 2 3 5.5 CCCCC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccc(O)cc1 10.1021/acs.jmedchem.0c00588
162666345 189124 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 401 9 1 2 5.4 CCCCN(Cc1ccc(-c2ccccc2C(=O)O)cc1)C(=O)Cc1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4784561 189124 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 401 9 1 2 5.4 CCCCN(Cc1ccc(-c2ccccc2C(=O)O)cc1)C(=O)Cc1ccccc1 10.1021/acs.jmedchem.0c00588
162648120 186712 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 402 8 2 2 5.6 CCCCNC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
CHEMBL4746259 186712 0 None - 0 Human 7.0 pEC50 = 7.0 Binding
Agonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assayAgonist activity at human BLT2 isoform 2 expressed in CHO-K1 cells over-expressing GNA14 assessed as stimulation of IP-1 accumulation incubated for 90 mins by IP-one assay
ChEMBL 402 8 2 2 5.6 CCCCNC(=O)N(Cc1ccc(-c2ccccc2C(=O)O)cc1)c1ccccc1 10.1021/acs.jmedchem.0c00588
122023 57569 60 None - 1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]LTB4 from HA-epitope tagged human BLT2 expressed in CHOK1 cells incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]LTB4 from HA-epitope tagged human BLT2 expressed in CHOK1 cells incubated for 60 mins by liquid scintillation counting method
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/acsmedchemlett.0c00065
CHEMBL15766 57569 60 None - 1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]LTB4 from HA-epitope tagged human BLT2 expressed in CHOK1 cells incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]LTB4 from HA-epitope tagged human BLT2 expressed in CHOK1 cells incubated for 60 mins by liquid scintillation counting method
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/acsmedchemlett.0c00065
CHEMBL45460 57569 60 None - 1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]LTB4 from HA-epitope tagged human BLT2 expressed in CHOK1 cells incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]LTB4 from HA-epitope tagged human BLT2 expressed in CHOK1 cells incubated for 60 mins by liquid scintillation counting method
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/acsmedchemlett.0c00065
51529932 7599 28 None -4 2 Human 7.8 pKd = 7.8 Binding
Displacement of [3H]LTB4 from HA-epitope tagged human BLT2 expressed in CHOK1 cells incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]LTB4 from HA-epitope tagged human BLT2 expressed in CHOK1 cells incubated for 60 mins by liquid scintillation counting method
ChEMBL 387 8 1 2 5.8 CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O 10.1021/acsmedchemlett.0c00065
6161 7599 28 None -4 2 Human 7.8 pKd = 7.8 Binding
Displacement of [3H]LTB4 from HA-epitope tagged human BLT2 expressed in CHOK1 cells incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]LTB4 from HA-epitope tagged human BLT2 expressed in CHOK1 cells incubated for 60 mins by liquid scintillation counting method
ChEMBL 387 8 1 2 5.8 CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O 10.1021/acsmedchemlett.0c00065
CHEMBL4637519 7599 28 None -4 2 Human 7.8 pKd = 7.8 Binding
Displacement of [3H]LTB4 from HA-epitope tagged human BLT2 expressed in CHOK1 cells incubated for 60 mins by liquid scintillation counting methodDisplacement of [3H]LTB4 from HA-epitope tagged human BLT2 expressed in CHOK1 cells incubated for 60 mins by liquid scintillation counting method
ChEMBL 387 8 1 2 5.8 CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O 10.1021/acsmedchemlett.0c00065
2487 9147 36 None -31 2 Human 7.6 pKd = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10934230
5280492 9147 36 None -31 2 Human 7.6 pKd = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10934230
CHEMBL65061 9147 36 None -31 2 Human 7.6 pKd = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10934230
DB12961 9147 36 None -31 2 Human 7.6 pKd = 7.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10934230
None 222981 0 3H-LTB4 -1 2 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 318 14 1 2 5.4 CCCCCC=CCC=CCC=CC=CC(=O)CCCC(=O)O None
None 222982 0 3H-LTB4 1 2 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 320 14 2 2 5.2 CCCCCC=CCC=CCC=CC=CC(CCCC(=O)O)O None
None 222983 0 3H-LTB4 10 2 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 320 15 2 2 5.2 C(CCC=CCC=CCC=CCC=CCCCC(=O)O)CCO None
None 222984 0 3H-LTB4 10 2 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 320 14 2 2 5.2 CCCCCC=CCC=CC=CC(CC=CCCCC(=O)O)O None
None 222985 0 3H-LTB4 -1 2 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 302 12 1 1 5.7 CCCCCC=CCC=CCC=CCC#CCCCC(=O)O None
2855 10904 104 3H-LTB4 -7762 6 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
3322 10904 104 3H-LTB4 -7762 6 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
5717 10904 104 3H-LTB4 -7762 6 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
CHEMBL603 10904 104 3H-LTB4 -7762 6 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
DB00549 10904 104 3H-LTB4 -7762 6 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
None 222987 0 3H-LTB4 -4365 4 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 473 7 2 3 7.9 CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)S)O None
None 222989 0 3H-LTB4 -2 2 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 496 20 5 6 3.4 CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N None
None 222992 0 3H-LTB4 -1 2 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 332 13 0 3 5.3 CCCCCC=CCC=CC=CC=CC1C(O1)CCCC(=O)OC None
132191096 222986 0 3H-LTB4 1 2 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 352 14 4 4 3.1 CCCCCC(C=CC=CC=CC=CC(C(CCCC(=O)O)O)O)O None
None 222979 0 3H-LTB4 6 2 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 318 14 1 2 5.4 CCCCCC=CCC(=O)C=CC=CCC=CCCCC(=O)O None
None 222978 0 3H-LTB4 57 2 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase 320 14 2 2 5.2 CCCCCC(C=CC=CCC=CCC=CCCCC(=O)O)O None
None 222976 0 3H-LTB4 -3 2 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 336 14 3 3 4.2 CCCCCC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O None
None 222982 0 3H-LTB4 1 2 Human 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 320 14 2 2 5.2 CCCCCC=CCC=CCC=CC=CC(CCCC(=O)O)O None
None 222980 0 3H-LTB4 -218 2 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 361 14 3 4 4.0 CCCCCC=CCC(C=CC1=NC(=CC=C1)CC(CCCCO)O)O None
None 222990 0 3H-LTB4 -2 2 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 439 18 4 5 4.3 CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)O)N None
None 222991 0 3H-LTB4 -1 2 Human 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 568 23 6 7 3.7 CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)O)NC(=O)CCC(C(=O)O)N None
None 222977 0 3H-LTB4 -2 2 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 334 13 3 3 3.9 CCC=CCC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O None
None 222988 0 3H-LTB4 -4 2 Human 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 625 25 7 8 2.8 CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N None
51529932 7599 28 None 4 2 Mouse 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 387 8 1 2 5.8 CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O 15866883
6161 7599 28 None 4 2 Mouse 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 387 8 1 2 5.8 CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O 15866883
CHEMBL4637519 7599 28 None 4 2 Mouse 8.5 pKi = 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 387 8 1 2 5.8 CCCCC(=O)N(c1ccccc1)Cc1ccc(cc1)c1ccccc1C(=O)O 15866883