Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
3352 | 9150 | 28 | None | -2041 | 4 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
5280879 | 9150 | 28 | None | -2041 | 4 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
5863 | 9150 | 28 | None | -2041 | 4 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
CHEMBL509456 | 9150 | 28 | None | -2041 | 4 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
5280878 | 107049 | 27 | None | -2 | 2 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1021/acs.jmedchem.1c01078 | ||
CHEMBL288943 | 107049 | 27 | None | -2 | 2 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1021/acs.jmedchem.1c01078 | ||
3354 | 9148 | 26 | None | -23 | 4 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
5280493 | 9148 | 26 | None | -23 | 4 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
CHEMBL451509 | 9148 | 26 | None | -23 | 4 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
DB08855 | 9148 | 26 | None | -23 | 4 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | ||
11455387 | 124697 | 0 | None | 77 | 2 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 531 | 14 | 2 | 6 | 5.6 | O=C(O)CCCN1CC(C(=O)O)Oc2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
CHEMBL3403187 | 124697 | 0 | None | 77 | 2 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 531 | 14 | 2 | 6 | 5.6 | O=C(O)CCCN1CC(C(=O)O)Oc2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
11398820 | 124565 | 0 | None | 1 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 556 | 13 | 3 | 8 | 4.7 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
CHEMBL3401689 | 124565 | 0 | None | 1 | 2 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 556 | 13 | 3 | 8 | 4.7 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
11307317 | 121809 | 0 | None | 194 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 546 | 14 | 3 | 6 | 5.2 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
CHEMBL3342959 | 121809 | 0 | None | 194 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 546 | 14 | 3 | 6 | 5.2 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
11398475 | 121814 | 4 | None | 19 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1C[C@@H](C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
CHEMBL3342964 | 121814 | 4 | None | 19 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1C[C@@H](C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
122183753 | 128992 | 0 | None | -3 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597618 | 128992 | 0 | None | -3 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
122183751 | 128990 | 0 | None | -1 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 543 | 10 | 2 | 4 | 6.4 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597616 | 128990 | 0 | None | -1 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 543 | 10 | 2 | 4 | 6.4 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
122183687 | 128967 | 0 | None | 2 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 579 | 14 | 2 | 4 | 7.4 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)ccc(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597530 | 128967 | 0 | None | 2 | 2 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 579 | 14 | 2 | 4 | 7.4 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)ccc(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
122183689 | 128969 | 0 | None | -1 | 2 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4cc(F)c(F)c(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597532 | 128969 | 0 | None | -1 | 2 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4cc(F)c(F)c(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
46830961 | 129003 | 0 | None | -3 | 3 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597628 | 129003 | 0 | None | -3 | 3 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
46830963 | 129007 | 0 | None | -3 | 3 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 641 | 14 | 2 | 4 | 7.7 | Cc1c(CCCC(=O)O)c2c(F)ccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597632 | 129007 | 0 | None | -3 | 3 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 641 | 14 | 2 | 4 | 7.7 | Cc1c(CCCC(=O)O)c2c(F)ccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
122183683 | 128963 | 0 | None | -4 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 543 | 14 | 2 | 4 | 7.2 | Cc1c(F)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)cn(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597526 | 128963 | 0 | None | -4 | 2 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 543 | 14 | 2 | 4 | 7.2 | Cc1c(F)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)cn(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
122183686 | 128966 | 0 | None | 3 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 555 | 15 | 2 | 5 | 7.0 | COc1ccccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597529 | 128966 | 0 | None | 3 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 555 | 15 | 2 | 5 | 7.0 | COc1ccccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
122183758 | 128998 | 0 | None | -19 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597623 | 128998 | 0 | None | -19 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
11353238 | 124695 | 0 | None | 2 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 541 | 14 | 2 | 7 | 5.2 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(CCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
CHEMBL3403185 | 124695 | 0 | None | 2 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 541 | 14 | 2 | 7 | 5.2 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(CCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
23124741 | 121810 | 0 | None | 1 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 520 | 12 | 3 | 7 | 3.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
CHEMBL3342960 | 121810 | 0 | None | 1 | 2 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 520 | 12 | 3 | 7 | 3.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
127043618 | 147303 | 0 | None | -2570 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1cccc2c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c(C(=O)O)[nH]c12 | 10.1021/acsmedchemlett.5b00482 | ||
CHEMBL3810210 | 147303 | 0 | None | -2570 | 2 | Human | 4.8 | pIC50 | = | 4.8 | Functional | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1cccc2c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c(C(=O)O)[nH]c12 | 10.1021/acsmedchemlett.5b00482 | ||
23124716 | 121811 | 0 | None | 18 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 534 | 13 | 3 | 7 | 4.3 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
CHEMBL3342961 | 121811 | 0 | None | 18 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 534 | 13 | 3 | 7 | 4.3 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
23124707 | 124564 | 0 | None | 5 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 517 | 14 | 2 | 5 | 5.4 | O=C(O)CCCN1CC(C(=O)O)Oc2c(CCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
CHEMBL3401688 | 124564 | 0 | None | 5 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 517 | 14 | 2 | 5 | 5.4 | O=C(O)CCCN1CC(C(=O)O)Oc2c(CCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
11227280 | 124566 | 0 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 609 | 14 | 3 | 8 | 3.8 | CS(=O)(=O)NC(=O)C1CN(CCCC(=O)O)c2cccc(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)c2O1 | 10.1016/j.bmc.2015.03.011 | ||
CHEMBL3401690 | 124566 | 0 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 609 | 14 | 3 | 8 | 3.8 | CS(=O)(=O)NC(=O)C1CN(CCCC(=O)O)c2cccc(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)c2O1 | 10.1016/j.bmc.2015.03.011 | ||
11284237 | 121812 | 0 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 548 | 14 | 3 | 7 | 4.7 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
CHEMBL3342962 | 121812 | 0 | None | 1 | 2 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 548 | 14 | 3 | 7 | 4.7 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
118716777 | 121806 | 1 | None | -3 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 546 | 14 | 3 | 6 | 5.2 | O=C(O)CCCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
CHEMBL3342956 | 121806 | 1 | None | -3 | 2 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 546 | 14 | 3 | 6 | 5.2 | O=C(O)CCCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
23124672 | 121803 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 560 | 13 | 3 | 6 | 4.8 | O=C(O)CCCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
CHEMBL3342953 | 121803 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 560 | 13 | 3 | 6 | 4.8 | O=C(O)CCCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
122183682 | 128962 | 0 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 565 | 14 | 2 | 4 | 7.1 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4c(F)ccc(F)c4F)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597525 | 128962 | 0 | None | -2 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 565 | 14 | 2 | 4 | 7.1 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4c(F)ccc(F)c4F)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
87131159 | 128970 | 0 | None | -1 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597533 | 128970 | 0 | None | -1 | 2 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
11191817 | 121805 | 2 | None | 3 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3342955 | 121805 | 2 | None | 3 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/acs.jmedchem.5b00741 | ||
11191817 | 121805 | 2 | None | 3 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
11191817 | 121805 | 2 | None | 3 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
CHEMBL3342955 | 121805 | 2 | None | 3 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
CHEMBL3342955 | 121805 | 2 | None | 3 | 2 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
122183756 | 128996 | 0 | None | -1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597621 | 128996 | 0 | None | -1 | 2 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
122183681 | 128961 | 0 | None | -7 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 545 | 14 | 2 | 4 | 7.4 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4cccc(Cl)c4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597524 | 128961 | 0 | None | -7 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 545 | 14 | 2 | 4 | 7.4 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4cccc(Cl)c4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
127043236 | 147210 | 0 | None | -660 | 2 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 467 | 5 | 3 | 3 | 6.5 | O=C(O)c1[nH]c2ccccc2c1C(=O)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
CHEMBL3809164 | 147210 | 0 | None | -660 | 2 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 467 | 5 | 3 | 3 | 6.5 | O=C(O)c1[nH]c2ccccc2c1C(=O)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
122183759 | 129000 | 0 | None | -3 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597625 | 129000 | 0 | None | -3 | 2 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
68695885 | 128960 | 0 | None | -7 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 511 | 14 | 2 | 4 | 6.7 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597523 | 128960 | 0 | None | -7 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 511 | 14 | 2 | 4 | 6.7 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
46830962 | 129009 | 21 | None | -14 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 601 | 14 | 2 | 4 | 7.6 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597634 | 129009 | 21 | None | -14 | 3 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 601 | 14 | 2 | 4 | 7.6 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
11853184 | 124700 | 3 | None | -2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCn1cc(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
CHEMBL3403190 | 124700 | 3 | None | -2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCn1cc(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
71654672 | 98657 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 510 | 19 | 2 | 5 | 7.0 | CCCCCCCCCCCCOc1cccc(/C=C/C(=O)c2cc(C(=O)O)ccc2OCC(=O)O)c1 | 10.1016/j.ejmech.2013.01.041 | ||
CHEMBL2413379 | 98657 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 510 | 19 | 2 | 5 | 7.0 | CCCCCCCCCCCCOc1cccc(/C=C/C(=O)c2cc(C(=O)O)ccc2OCC(=O)O)c1 | 10.1016/j.ejmech.2013.01.041 | ||
11853184 | 124700 | 3 | None | -2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCn1cc(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3403190 | 124700 | 3 | None | -2 | 2 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCn1cc(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1021/acs.jmedchem.5b00741 | ||
1836 | 9370 | 59 | None | -53703 | 18 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | ||
3340 | 9370 | 59 | None | -53703 | 18 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | ||
5281040 | 9370 | 59 | None | -53703 | 18 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | ||
CHEMBL787 | 9370 | 59 | None | -53703 | 18 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | ||
DB00471 | 9370 | 59 | None | -53703 | 18 | Human | 4.6 | pIC50 | = | 4.6 | Functional | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | ||
23124775 | 121807 | 0 | None | -2 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 560 | 15 | 3 | 6 | 5.6 | O=C(O)CCCCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
CHEMBL3342957 | 121807 | 0 | None | -2 | 2 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 560 | 15 | 3 | 6 | 5.6 | O=C(O)CCCCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
11261220 | 124696 | 0 | None | -5 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 539 | 13 | 2 | 7 | 5.6 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
CHEMBL3403186 | 124696 | 0 | None | -5 | 2 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 539 | 13 | 2 | 7 | 5.6 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
46830677 | 129006 | 0 | None | -1 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 623 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597631 | 129006 | 0 | None | -1 | 3 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 623 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
122183688 | 128968 | 0 | None | -1 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)c(F)cc(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597531 | 128968 | 0 | None | -1 | 2 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)c(F)cc(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
10438479 | 8693 | 23 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 595 | 16 | 3 | 6 | 6.3 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOC1CCCCC1)C(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
6197 | 8693 | 23 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 595 | 16 | 3 | 6 | 6.3 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOC1CCCCC1)C(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3342944 | 8693 | 23 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 595 | 16 | 3 | 6 | 6.3 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOC1CCCCC1)C(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
122183761 | 129002 | 0 | None | 1 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 613 | 15 | 2 | 4 | 8.4 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597627 | 129002 | 0 | None | 1 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 613 | 15 | 2 | 4 | 8.4 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
11249398 | 124562 | 0 | None | 1 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 519 | 14 | 2 | 6 | 5.2 | O=C(O)CCCN1CC(C(=O)O)Oc2c(OCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
CHEMBL3401686 | 124562 | 0 | None | 1 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 519 | 14 | 2 | 6 | 5.2 | O=C(O)CCCN1CC(C(=O)O)Oc2c(OCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
3381 | 7376 | 27 | None | -3 | 3 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1021/ml500298y | ||
5311015 | 7376 | 27 | None | -3 | 3 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1021/ml500298y | ||
CHEMBL285954 | 7376 | 27 | None | -3 | 3 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1021/ml500298y | ||
122183762 | 129004 | 0 | None | -1 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cc(F)cc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597629 | 129004 | 0 | None | -1 | 2 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cc(F)cc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
118716774 | 121800 | 0 | None | -281 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 488 | 9 | 2 | 5 | 4.5 | CC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
CHEMBL3342950 | 121800 | 0 | None | -281 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 488 | 9 | 2 | 5 | 4.5 | CC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
127043053 | 147306 | 0 | None | -537 | 2 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2cccc(Cl)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
CHEMBL3810290 | 147306 | 0 | None | -537 | 2 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2cccc(Cl)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
118729614 | 124698 | 0 | None | -1 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 541 | 14 | 2 | 6 | 6.0 | O=C(O)CCCn1cc(C(=O)O)c(=O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
CHEMBL3403188 | 124698 | 0 | None | -1 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 541 | 14 | 2 | 6 | 6.0 | O=C(O)CCCn1cc(C(=O)O)c(=O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
118716776 | 121610 | 0 | None | -12 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 516 | 11 | 2 | 5 | 5.3 | CCCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
CHEMBL3341770 | 121610 | 0 | None | -12 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 516 | 11 | 2 | 5 | 5.3 | CCCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
10438479 | 8693 | 23 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 595 | 16 | 3 | 6 | 6.3 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOC1CCCCC1)C(=O)O | 10.1021/acsmedchemlett.5b00482 | ||
6197 | 8693 | 23 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 595 | 16 | 3 | 6 | 6.3 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOC1CCCCC1)C(=O)O | 10.1021/acsmedchemlett.5b00482 | ||
CHEMBL3342944 | 8693 | 23 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 595 | 16 | 3 | 6 | 6.3 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOC1CCCCC1)C(=O)O | 10.1021/acsmedchemlett.5b00482 | ||
10438479 | 8693 | 23 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 595 | 16 | 3 | 6 | 6.3 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOC1CCCCC1)C(=O)O | 10.1021/ml500298y | ||
6197 | 8693 | 23 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 595 | 16 | 3 | 6 | 6.3 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOC1CCCCC1)C(=O)O | 10.1021/ml500298y | ||
CHEMBL3342944 | 8693 | 23 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 595 | 16 | 3 | 6 | 6.3 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOC1CCCCC1)C(=O)O | 10.1021/ml500298y | ||
122183684 | 128964 | 0 | None | -7 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 559 | 14 | 2 | 4 | 7.7 | Cc1c(Cl)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)cn(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597527 | 128964 | 0 | None | -7 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 559 | 14 | 2 | 4 | 7.7 | Cc1c(Cl)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)cn(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
122183685 | 128965 | 0 | None | -1 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 525 | 14 | 2 | 4 | 7.0 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4ccccc4)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597528 | 128965 | 0 | None | -1 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 525 | 14 | 2 | 4 | 7.0 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4ccccc4)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | ||
118729613 | 124694 | 0 | None | 1 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 518 | 13 | 3 | 6 | 4.8 | O=C(O)CCCN1CC(CO)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
CHEMBL3403184 | 124694 | 0 | None | 1 | 2 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 518 | 13 | 3 | 6 | 4.8 | O=C(O)CCCN1CC(CO)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
118728613 | 124568 | 0 | None | -2 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 488 | 12 | 2 | 5 | 5.4 | O=C(O)CCCN1CCOc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
CHEMBL3401692 | 124568 | 0 | None | -2 | 2 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 488 | 12 | 2 | 5 | 5.4 | O=C(O)CCCN1CCOc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
2237 | 9936 | 79 | None | -3630 | 10 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | ||
3634 | 9936 | 79 | None | -3630 | 10 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | ||
4887 | 9936 | 79 | None | -3630 | 10 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | ||
CHEMBL21333 | 9936 | 79 | None | -3630 | 10 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | ||
DB01411 | 9936 | 79 | None | -3630 | 10 | Human | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | ||
90871050 | 121797 | 0 | None | -85 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1cccc2c1OC(C(=O)O)CN2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | ||
CHEMBL3342947 | 121797 | 0 | None | -85 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1cccc2c1OC(C(=O)O)CN2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | ||
127043248 | 147168 | 0 | None | -1819 | 2 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1ccc2[nH]c(C(=O)O)c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c2c1 | 10.1021/acsmedchemlett.5b00482 | ||
CHEMBL3808613 | 147168 | 0 | None | -1819 | 2 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1ccc2[nH]c(C(=O)O)c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c2c1 | 10.1021/acsmedchemlett.5b00482 | ||
127043244 | 147213 | 0 | None | -5888 | 2 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 511 | 6 | 3 | 3 | 7.0 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccc(F)cc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
CHEMBL3809189 | 147213 | 0 | None | -5888 | 2 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 511 | 6 | 3 | 3 | 7.0 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccc(F)cc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
122183763 | 129005 | 0 | None | -4 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2c(F)ccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597630 | 129005 | 0 | None | -4 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2c(F)ccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
66739117 | 128972 | 0 | None | -9 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 573 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597535 | 128972 | 0 | None | -9 | 2 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 573 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
46834997 | 128999 | 0 | None | -3 | 3 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597624 | 128999 | 0 | None | -3 | 3 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
122183752 | 128991 | 0 | None | -17 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 557 | 11 | 2 | 4 | 6.8 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597617 | 128991 | 0 | None | -17 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 557 | 11 | 2 | 4 | 6.8 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
23124680 | 124563 | 0 | None | 12 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 515 | 13 | 2 | 5 | 5.8 | O=C(O)CCCN1CC(C(=O)O)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
CHEMBL3401687 | 124563 | 0 | None | 12 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 515 | 13 | 2 | 5 | 5.8 | O=C(O)CCCN1CC(C(=O)O)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
23124664 | 124567 | 0 | None | 12 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 671 | 15 | 3 | 8 | 5.3 | O=C(O)CCCN1CC(C(=O)NS(=O)(=O)c2ccccc2)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
CHEMBL3401691 | 124567 | 0 | None | 12 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 671 | 15 | 3 | 8 | 5.3 | O=C(O)CCCN1CC(C(=O)NS(=O)(=O)c2ccccc2)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | ||
127043237 | 147198 | 0 | None | -870 | 2 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 495 | 7 | 3 | 3 | 6.8 | O=C(CCc1c(C(=O)O)[nH]c2ccccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
CHEMBL3808985 | 147198 | 0 | None | -870 | 2 | Human | 4.3 | pIC50 | = | 4.3 | Functional | ChEMBL | 495 | 7 | 3 | 3 | 6.8 | O=C(CCc1c(C(=O)O)[nH]c2ccccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
118716775 | 121801 | 0 | None | -34 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 502 | 10 | 2 | 5 | 4.9 | CCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
CHEMBL3342951 | 121801 | 0 | None | -34 | 2 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 502 | 10 | 2 | 5 | 4.9 | CCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
53394034 | 7375 | 22 | None | 21 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 10.1021/acsmedchemlett.5b00482 | ||
6196 | 7375 | 22 | None | 21 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 10.1021/acsmedchemlett.5b00482 | ||
CHEMBL3342945 | 7375 | 22 | None | 21 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 10.1021/acsmedchemlett.5b00482 | ||
53394034 | 7375 | 22 | None | 21 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 10.1021/ml500298y | ||
6196 | 7375 | 22 | None | 21 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 10.1021/ml500298y | ||
CHEMBL3342945 | 7375 | 22 | None | 21 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 10.1021/ml500298y | ||
122183757 | 128997 | 0 | None | -10 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597622 | 128997 | 0 | None | -10 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
11387037 | 121813 | 0 | None | -1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1C[C@H](C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
CHEMBL3342963 | 121813 | 0 | None | -1 | 2 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1C[C@H](C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
2855 | 10904 | 104 | None | -776 | 12 | Human | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | ||
3322 | 10904 | 104 | None | -776 | 12 | Human | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | ||
5717 | 10904 | 104 | None | -776 | 12 | Human | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | ||
CHEMBL603 | 10904 | 104 | None | -776 | 12 | Human | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | ||
DB00549 | 10904 | 104 | None | -776 | 12 | Human | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | ||
127043050 | 147217 | 0 | None | -6456 | 2 | Human | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 493 | 6 | 3 | 3 | 6.9 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
CHEMBL3809230 | 147217 | 0 | None | -6456 | 2 | Human | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 493 | 6 | 3 | 3 | 6.9 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
11713438 | 128959 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597522 | 128959 | 0 | None | -3 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | ||
122183760 | 129001 | 0 | None | -2 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597626 | 129001 | 0 | None | -2 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
23124623 | 121808 | 0 | None | 19 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 518 | 12 | 3 | 6 | 4.5 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
CHEMBL3342958 | 121808 | 0 | None | 19 | 2 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 518 | 12 | 3 | 6 | 4.5 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
122183690 | 128971 | 0 | None | -6 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 557 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597534 | 128971 | 0 | None | -6 | 2 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 557 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
118729615 | 124699 | 0 | None | 6 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 542 | 15 | 2 | 7 | 6.0 | O=C(O)CCCOc1nc2cccc(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)c2nc1C(=O)O | 10.1016/j.bmc.2015.03.011 | ||
CHEMBL3403189 | 124699 | 0 | None | 6 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 542 | 15 | 2 | 7 | 6.0 | O=C(O)CCCOc1nc2cccc(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)c2nc1C(=O)O | 10.1016/j.bmc.2015.03.011 | ||
71654671 | 98656 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 524 | 14 | 2 | 6 | 5.6 | O=C(O)COc1ccc(C(=O)O)cc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.ejmech.2013.01.041 | ||
CHEMBL2413378 | 98656 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 524 | 14 | 2 | 6 | 5.6 | O=C(O)COc1ccc(C(=O)O)cc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.ejmech.2013.01.041 | ||
127043247 | 147195 | 0 | None | -1995 | 2 | Human | 4.1 | pIC50 | = | 4.1 | Functional | ChEMBL | 529 | 6 | 3 | 3 | 7.2 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(F)cc(F)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
CHEMBL3808968 | 147195 | 0 | None | -1995 | 2 | Human | 4.1 | pIC50 | = | 4.1 | Functional | ChEMBL | 529 | 6 | 3 | 3 | 7.2 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(F)cc(F)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
54677430 | 121796 | 0 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 510 | 8 | 2 | 7 | 5.1 | CCN(CC)C(=O)/C=C(\C)c1ccc2oc(C(=O)c3ccc(C#N)cc3)c(NC(=O)/C(C#N)=C(/C)O)c2c1 | 10.1021/ml500298y | ||
CHEMBL3342946 | 121796 | 0 | None | 1 | 2 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 510 | 8 | 2 | 7 | 5.1 | CCN(CC)C(=O)/C=C(\C)c1ccc2oc(C(=O)c3ccc(C#N)cc3)c(NC(=O)/C(C#N)=C(/C)O)c2c1 | 10.1021/ml500298y | ||
122183755 | 128995 | 0 | None | -7 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597620 | 128995 | 0 | None | -7 | 2 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
46835000 | 129008 | 0 | None | -7 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 583 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597633 | 129008 | 0 | None | -7 | 3 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 583 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
127043242 | 147228 | 0 | None | -3981 | 2 | Human | 4.1 | pIC50 | = | 4.1 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)ccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
CHEMBL3809333 | 147228 | 0 | None | -3981 | 2 | Human | 4.1 | pIC50 | = | 4.1 | Functional | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)ccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | ||
23124563 | 121802 | 0 | None | -630 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 546 | 12 | 3 | 6 | 4.4 | O=C(O)CCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
CHEMBL3342952 | 121802 | 0 | None | -630 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 546 | 12 | 3 | 6 | 4.4 | O=C(O)CCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
23124629 | 121804 | 0 | None | -74 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 574 | 14 | 3 | 6 | 5.2 | O=C(O)CCCCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
CHEMBL3342954 | 121804 | 0 | None | -74 | 2 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 574 | 14 | 3 | 6 | 5.2 | O=C(O)CCCCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | ||
122183754 | 128993 | 0 | None | -7 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 557 | 11 | 2 | 4 | 6.8 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
CHEMBL3597619 | 128993 | 0 | None | -7 | 2 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 557 | 11 | 2 | 4 | 6.8 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | ||
5861 | 8846 | 0 | None | - | 1 | Human | 6.8 | pA2 | = | 6.8 | Functional | Guide to Pharmacology | 710 | 16 | 3 | 8 | 8.9 | CCCc1c(OCCCC/C=C\C=C\[C@@H]([C@@H](c2cccc(c2)C(F)(F)F)O)Sc2ccc3c(c2)oc(cc3=O)C(=O)O)ccc(c1O)C(=O)C | 25839425 | ||
6913104 | 8846 | 0 | None | - | 1 | Human | 6.8 | pA2 | = | 6.8 | Functional | Guide to Pharmacology | 710 | 16 | 3 | 8 | 8.9 | CCCc1c(OCCCC/C=C\C=C\[C@@H]([C@@H](c2cccc(c2)C(F)(F)F)O)Sc2ccc3c(c2)oc(cc3=O)C(=O)O)ccc(c1O)C(=O)C | 25839425 | ||
CHEMBL1206833 | 8846 | 0 | None | - | 1 | Human | 6.8 | pA2 | = | 6.8 | Functional | Guide to Pharmacology | 710 | 16 | 3 | 8 | 8.9 | CCCc1c(OCCCC/C=C\C=C\[C@@H]([C@@H](c2cccc(c2)C(F)(F)F)O)Sc2ccc3c(c2)oc(cc3=O)C(=O)O)ccc(c1O)C(=O)C | 25839425 | ||
2855 | 10904 | 104 | None | -776 | 12 | Human | 6.9 | pA2 | = | 6.9 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 25839425 | ||
3322 | 10904 | 104 | None | -776 | 12 | Human | 6.9 | pA2 | = | 6.9 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 25839425 | ||
5717 | 10904 | 104 | None | -776 | 12 | Human | 6.9 | pA2 | = | 6.9 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 25839425 | ||
CHEMBL603 | 10904 | 104 | None | -776 | 12 | Human | 6.9 | pA2 | = | 6.9 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 25839425 | ||
DB00549 | 10904 | 104 | None | -776 | 12 | Human | 6.9 | pA2 | = | 6.9 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 25839425 | ||
3334 | 9921 | 9 | None | -48 | 2 | Human | 6.2 | pA2 | = | 6.2 | Functional | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 25839425 | ||
60842 | 9921 | 9 | None | -48 | 2 | Human | 6.2 | pA2 | = | 6.2 | Functional | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 25839425 | ||
CHEMBL22776 | 9921 | 9 | None | -48 | 2 | Human | 6.2 | pA2 | = | 6.2 | Functional | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 25839425 | ||
2237 | 9936 | 79 | None | -3630 | 10 | Human | 7.1 | pA2 | = | 7.1 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 25839425 | ||
3634 | 9936 | 79 | None | -3630 | 10 | Human | 7.1 | pA2 | = | 7.1 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 25839425 | ||
4887 | 9936 | 79 | None | -3630 | 10 | Human | 7.1 | pA2 | = | 7.1 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 25839425 | ||
CHEMBL21333 | 9936 | 79 | None | -3630 | 10 | Human | 7.1 | pA2 | = | 7.1 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 25839425 | ||
DB01411 | 9936 | 79 | None | -3630 | 10 | Human | 7.1 | pA2 | = | 7.1 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 25839425 | ||
53394034 | 7375 | 22 | None | 21 | 2 | Human | 8.4 | pA2 | = | 8.4 | Functional | Guide to Pharmacology | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 21753081 | ||
6196 | 7375 | 22 | None | 21 | 2 | Human | 8.4 | pA2 | = | 8.4 | Functional | Guide to Pharmacology | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 21753081 | ||
CHEMBL3342945 | 7375 | 22 | None | 21 | 2 | Human | 8.4 | pA2 | = | 8.4 | Functional | Guide to Pharmacology | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 21753081 | ||
3381 | 7376 | 27 | None | 3 | 3 | Rat | 7.3 | pA2 | = | 7.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 7698171 | ||
5311015 | 7376 | 27 | None | 3 | 3 | Rat | 7.3 | pA2 | = | 7.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 7698171 | ||
CHEMBL285954 | 7376 | 27 | None | 3 | 3 | Rat | 7.3 | pA2 | = | 7.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 7698171 | ||
53394034 | 7375 | 22 | None | 21 | 2 | Human | 8.3 | pA2 | = | 8.3 | Functional | Guide to Pharmacology | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 21753081 | ||
6196 | 7375 | 22 | None | 21 | 2 | Human | 8.3 | pA2 | = | 8.3 | Functional | Guide to Pharmacology | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 21753081 | ||
CHEMBL3342945 | 7375 | 22 | None | 21 | 2 | Human | 8.3 | pA2 | = | 8.3 | Functional | Guide to Pharmacology | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 21753081 | ||
3352 | 9150 | 28 | None | -2041 | 4 | Human | 5.8 | pEC50 | = | 5.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10851239 | ||
3352 | 9150 | 28 | None | -2041 | 4 | Human | 5.8 | pEC50 | = | 5.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 21078884 | ||
5280879 | 9150 | 28 | None | -2041 | 4 | Human | 5.8 | pEC50 | = | 5.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10851239 | ||
5280879 | 9150 | 28 | None | -2041 | 4 | Human | 5.8 | pEC50 | = | 5.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 21078884 | ||
5863 | 9150 | 28 | None | -2041 | 4 | Human | 5.8 | pEC50 | = | 5.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10851239 | ||
5863 | 9150 | 28 | None | -2041 | 4 | Human | 5.8 | pEC50 | = | 5.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 21078884 | ||
CHEMBL509456 | 9150 | 28 | None | -2041 | 4 | Human | 5.8 | pEC50 | = | 5.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10851239 | ||
CHEMBL509456 | 9150 | 28 | None | -2041 | 4 | Human | 5.8 | pEC50 | = | 5.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 21078884 | ||
3352 | 9150 | 28 | None | -2041 | 4 | Human | 6.8 | pEC50 | = | 6.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | ||
3352 | 9150 | 28 | None | -2041 | 4 | Human | 6.8 | pEC50 | = | 6.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | ||
5280879 | 9150 | 28 | None | -2041 | 4 | Human | 6.8 | pEC50 | = | 6.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | ||
5280879 | 9150 | 28 | None | -2041 | 4 | Human | 6.8 | pEC50 | = | 6.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | ||
5863 | 9150 | 28 | None | -2041 | 4 | Human | 6.8 | pEC50 | = | 6.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | ||
5863 | 9150 | 28 | None | -2041 | 4 | Human | 6.8 | pEC50 | = | 6.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | ||
CHEMBL509456 | 9150 | 28 | None | -2041 | 4 | Human | 6.8 | pEC50 | = | 6.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | ||
CHEMBL509456 | 9150 | 28 | None | -2041 | 4 | Human | 6.8 | pEC50 | = | 6.8 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | ||
3353 | 9149 | 0 | None | -41 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10851239 | ||
3353 | 9149 | 0 | None | -41 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21078884 | ||
3412 | 9149 | 0 | None | -41 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10851239 | ||
3412 | 9149 | 0 | None | -41 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21078884 | ||
6435286 | 9149 | 0 | None | -41 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10851239 | ||
6435286 | 9149 | 0 | None | -41 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21078884 | ||
CHEMBL1521056 | 9149 | 0 | None | -41 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10851239 | ||
CHEMBL1521056 | 9149 | 0 | None | -41 | 4 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21078884 | ||
6194 | 9610 | 0 | None | 61 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 639 | 26 | 7 | 8 | 3.0 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)NC | 21078884 | ||
73755185 | 9610 | 0 | None | 61 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | Guide to Pharmacology | 639 | 26 | 7 | 8 | 3.0 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)NC | 21078884 | ||
3381 | 7376 | 27 | None | -3 | 3 | Human | 7.0 | pEC50 | = | 7.0 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 11093801 | ||
5311015 | 7376 | 27 | None | -3 | 3 | Human | 7.0 | pEC50 | = | 7.0 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 11093801 | ||
CHEMBL285954 | 7376 | 27 | None | -3 | 3 | Human | 7.0 | pEC50 | = | 7.0 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 11093801 | ||
3354 | 9148 | 26 | None | -23 | 4 | Human | 7.1 | pEC50 | = | 7.1 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10851239 | ||
3354 | 9148 | 26 | None | -23 | 4 | Human | 7.1 | pEC50 | = | 7.1 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 21078884 | ||
5280493 | 9148 | 26 | None | -23 | 4 | Human | 7.1 | pEC50 | = | 7.1 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10851239 | ||
5280493 | 9148 | 26 | None | -23 | 4 | Human | 7.1 | pEC50 | = | 7.1 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 21078884 | ||
CHEMBL451509 | 9148 | 26 | None | -23 | 4 | Human | 7.1 | pEC50 | = | 7.1 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10851239 | ||
CHEMBL451509 | 9148 | 26 | None | -23 | 4 | Human | 7.1 | pEC50 | = | 7.1 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 21078884 | ||
DB08855 | 9148 | 26 | None | -23 | 4 | Human | 7.1 | pEC50 | = | 7.1 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10851239 | ||
DB08855 | 9148 | 26 | None | -23 | 4 | Human | 7.1 | pEC50 | = | 7.1 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 21078884 | ||
3381 | 7376 | 27 | None | -3 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 20423349 | ||
5311015 | 7376 | 27 | None | -3 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 20423349 | ||
CHEMBL285954 | 7376 | 27 | None | -3 | 3 | Human | 7.2 | pEC50 | = | 7.2 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 20423349 | ||
3354 | 9148 | 26 | None | -23 | 4 | Human | 7.2 | pEC50 | = | 7.2 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 21753081 | ||
5280493 | 9148 | 26 | None | -23 | 4 | Human | 7.2 | pEC50 | = | 7.2 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 21753081 | ||
CHEMBL451509 | 9148 | 26 | None | -23 | 4 | Human | 7.2 | pEC50 | = | 7.2 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 21753081 | ||
DB08855 | 9148 | 26 | None | -23 | 4 | Human | 7.2 | pEC50 | = | 7.2 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 21753081 | ||
3354 | 9148 | 26 | None | -23 | 4 | Human | 7.3 | pEC50 | = | 7.3 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 21078884 | ||
5280493 | 9148 | 26 | None | -23 | 4 | Human | 7.3 | pEC50 | = | 7.3 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 21078884 | ||
CHEMBL451509 | 9148 | 26 | None | -23 | 4 | Human | 7.3 | pEC50 | = | 7.3 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 21078884 | ||
DB08855 | 9148 | 26 | None | -23 | 4 | Human | 7.3 | pEC50 | = | 7.3 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 21078884 | ||
3353 | 9149 | 0 | None | -41 | 4 | Human | 7.4 | pEC50 | = | 7.4 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | ||
3412 | 9149 | 0 | None | -41 | 4 | Human | 7.4 | pEC50 | = | 7.4 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | ||
6435286 | 9149 | 0 | None | -41 | 4 | Human | 7.4 | pEC50 | = | 7.4 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | ||
CHEMBL1521056 | 9149 | 0 | None | -41 | 4 | Human | 7.4 | pEC50 | = | 7.4 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | ||
3353 | 9149 | 0 | None | -41 | 4 | Human | 7.5 | pEC50 | = | 7.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21078884 | ||
3412 | 9149 | 0 | None | -41 | 4 | Human | 7.5 | pEC50 | = | 7.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21078884 | ||
6435286 | 9149 | 0 | None | -41 | 4 | Human | 7.5 | pEC50 | = | 7.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21078884 | ||
CHEMBL1521056 | 9149 | 0 | None | -41 | 4 | Human | 7.5 | pEC50 | = | 7.5 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21078884 | ||
6194 | 9610 | 0 | None | 61 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | Guide to Pharmacology | 639 | 26 | 7 | 8 | 3.0 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)NC | 21078884 | ||
73755185 | 9610 | 0 | None | 61 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | Guide to Pharmacology | 639 | 26 | 7 | 8 | 3.0 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)NC | 21078884 | ||
3353 | 9149 | 0 | None | -41 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | ||
3353 | 9149 | 0 | None | -41 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | ||
3353 | 9149 | 0 | None | -41 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | ||
3412 | 9149 | 0 | None | -41 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | ||
3412 | 9149 | 0 | None | -41 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | ||
3412 | 9149 | 0 | None | -41 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | ||
6435286 | 9149 | 0 | None | -41 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | ||
6435286 | 9149 | 0 | None | -41 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | ||
6435286 | 9149 | 0 | None | -41 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | ||
CHEMBL1521056 | 9149 | 0 | None | -41 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | ||
CHEMBL1521056 | 9149 | 0 | None | -41 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | ||
CHEMBL1521056 | 9149 | 0 | None | -41 | 4 | Human | 8.3 | pEC50 | = | 8.3 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | ||
3354 | 9148 | 26 | None | -23 | 4 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10913337 | ||
3354 | 9148 | 26 | None | -23 | 4 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | ||
5280493 | 9148 | 26 | None | -23 | 4 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10913337 | ||
5280493 | 9148 | 26 | None | -23 | 4 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | ||
CHEMBL451509 | 9148 | 26 | None | -23 | 4 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10913337 | ||
CHEMBL451509 | 9148 | 26 | None | -23 | 4 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | ||
DB08855 | 9148 | 26 | None | -23 | 4 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10913337 | ||
DB08855 | 9148 | 26 | None | -23 | 4 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | ||
2855 | 10904 | 104 | None | -776 | 12 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
3322 | 10904 | 104 | None | -776 | 12 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
5717 | 10904 | 104 | None | -776 | 12 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
CHEMBL603 | 10904 | 104 | None | -776 | 12 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
DB00549 | 10904 | 104 | None | -776 | 12 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | ||
2237 | 9936 | 79 | None | -3630 | 10 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
3634 | 9936 | 79 | None | -3630 | 10 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
4887 | 9936 | 79 | None | -3630 | 10 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
CHEMBL21333 | 9936 | 79 | None | -3630 | 10 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
DB01411 | 9936 | 79 | None | -3630 | 10 | Human | 8.3 | pIC50 | = | 8.3 | Functional | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | ||
60490 | 214040 | 106 | None | 8 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 236 | 2 | 2 | 3 | 2.7 | CC(c1cc2ccccc2s1)N(O)C(N)=O | None | ||
CHEMBL93 | 214040 | 106 | None | 8 | 2 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 236 | 2 | 2 | 3 | 2.7 | CC(c1cc2ccccc2s1)N(O)C(N)=O | None | ||
10580 | 9705 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | 584 | 13 | 3 | 6 | 5.7 | OC(=O)CCCN1C[C@H](Oc2c1cccc2NC(=O)c1ccc(cc1)OCCCCc1cc(F)ccc1Cl)C(=O)O | 31811124 | ||
145704683 | 9705 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | Guide to Pharmacology | 584 | 13 | 3 | 6 | 5.7 | OC(=O)CCCN1C[C@H](Oc2c1cccc2NC(=O)c1ccc(cc1)OCCCCc1cc(F)ccc1Cl)C(=O)O | 31811124 | ||
10581 | 7770 | 0 | None | -1819 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | Guide to Pharmacology | 587 | 17 | 2 | 7 | 5.4 | O=C(CN1CC(Oc2c1cccc2CC(=O)c1ccc(cc1)OCCCCCc1ccccc1)C(=O)O)CCCC(=O)O | 31811124 | ||
145996520 | 7770 | 0 | None | -1819 | 2 | Human | 5.7 | pIC50 | = | 5.7 | Functional | Guide to Pharmacology | 587 | 17 | 2 | 7 | 5.4 | O=C(CN1CC(Oc2c1cccc2CC(=O)c1ccc(cc1)OCCCCCc1ccccc1)C(=O)O)CCCC(=O)O | 31811124 | ||
10582 | 7778 | 0 | None | 194 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | 573 | 17 | 2 | 6 | 6.2 | OC(=O)CCCCN1CC(Oc2c1cccc2CC(=O)c1ccc(cc1)OCCCCCCc1ccccc1)C(=O)O | 31811124 | ||
145996521 | 7778 | 0 | None | 194 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Functional | Guide to Pharmacology | 573 | 17 | 2 | 6 | 6.2 | OC(=O)CCCCN1CC(Oc2c1cccc2CC(=O)c1ccc(cc1)OCCCCCCc1ccccc1)C(=O)O | 31811124 | ||
2855 | 10904 | 104 | None | -776 | 12 | Human | 5.1 | pIC50 | = | 5.1 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10851239 | ||
3322 | 10904 | 104 | None | -776 | 12 | Human | 5.1 | pIC50 | = | 5.1 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10851239 | ||
5717 | 10904 | 104 | None | -776 | 12 | Human | 5.1 | pIC50 | = | 5.1 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10851239 | ||
CHEMBL603 | 10904 | 104 | None | -776 | 12 | Human | 5.1 | pIC50 | = | 5.1 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10851239 | ||
DB00549 | 10904 | 104 | None | -776 | 12 | Human | 5.1 | pIC50 | = | 5.1 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10851239 | ||
2855 | 10904 | 104 | None | -776 | 12 | Human | 5.2 | pIC50 | = | 5.2 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | ||
3322 | 10904 | 104 | None | -776 | 12 | Human | 5.2 | pIC50 | = | 5.2 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | ||
5717 | 10904 | 104 | None | -776 | 12 | Human | 5.2 | pIC50 | = | 5.2 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | ||
CHEMBL603 | 10904 | 104 | None | -776 | 12 | Human | 5.2 | pIC50 | = | 5.2 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | ||
DB00549 | 10904 | 104 | None | -776 | 12 | Human | 5.2 | pIC50 | = | 5.2 | Functional | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | ||
3381 | 7376 | 27 | None | -3 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 21903747 | ||
5311015 | 7376 | 27 | None | -3 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 21903747 | ||
CHEMBL285954 | 7376 | 27 | None | -3 | 3 | Human | 5.3 | pIC50 | = | 5.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 21903747 | ||
3352 | 9150 | 28 | None | -2041 | 4 | Human | 5.7 | pIC50 | = | 5.7 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | ||
5280879 | 9150 | 28 | None | -2041 | 4 | Human | 5.7 | pIC50 | = | 5.7 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | ||
5863 | 9150 | 28 | None | -2041 | 4 | Human | 5.7 | pIC50 | = | 5.7 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | ||
CHEMBL509456 | 9150 | 28 | None | -2041 | 4 | Human | 5.7 | pIC50 | = | 5.7 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | ||
3352 | 9150 | 28 | None | -2041 | 4 | Human | 6.2 | pIC50 | = | 6.2 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10851239 | ||
3352 | 9150 | 28 | None | -2041 | 4 | Human | 6.2 | pIC50 | = | 6.2 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | ||
5280879 | 9150 | 28 | None | -2041 | 4 | Human | 6.2 | pIC50 | = | 6.2 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10851239 | ||
5280879 | 9150 | 28 | None | -2041 | 4 | Human | 6.2 | pIC50 | = | 6.2 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | ||
5863 | 9150 | 28 | None | -2041 | 4 | Human | 6.2 | pIC50 | = | 6.2 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10851239 | ||
5863 | 9150 | 28 | None | -2041 | 4 | Human | 6.2 | pIC50 | = | 6.2 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | ||
CHEMBL509456 | 9150 | 28 | None | -2041 | 4 | Human | 6.2 | pIC50 | = | 6.2 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10851239 | ||
CHEMBL509456 | 9150 | 28 | None | -2041 | 4 | Human | 6.2 | pIC50 | = | 6.2 | Functional | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | ||
3381 | 7376 | 27 | None | -3 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10851239 | ||
3381 | 7376 | 27 | None | -3 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 11093801 | ||
3381 | 7376 | 27 | None | -3 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 20423349 | ||
5311015 | 7376 | 27 | None | -3 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10851239 | ||
5311015 | 7376 | 27 | None | -3 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 11093801 | ||
5311015 | 7376 | 27 | None | -3 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 20423349 | ||
CHEMBL285954 | 7376 | 27 | None | -3 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10851239 | ||
CHEMBL285954 | 7376 | 27 | None | -3 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 11093801 | ||
CHEMBL285954 | 7376 | 27 | None | -3 | 3 | Human | 6.3 | pIC50 | = | 6.3 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 20423349 | ||
3381 | 7376 | 27 | None | -3 | 3 | Human | 6.5 | pIC50 | = | 6.5 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 11093801 | ||
5311015 | 7376 | 27 | None | -3 | 3 | Human | 6.5 | pIC50 | = | 6.5 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 11093801 | ||
CHEMBL285954 | 7376 | 27 | None | -3 | 3 | Human | 6.5 | pIC50 | = | 6.5 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 11093801 | ||
3353 | 9149 | 0 | None | -41 | 4 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | ||
3412 | 9149 | 0 | None | -41 | 4 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | ||
6435286 | 9149 | 0 | None | -41 | 4 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | ||
CHEMBL1521056 | 9149 | 0 | None | -41 | 4 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | ||
3381 | 7376 | 27 | None | -3 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 20423349 | ||
5311015 | 7376 | 27 | None | -3 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 20423349 | ||
CHEMBL285954 | 7376 | 27 | None | -3 | 3 | Human | 7.7 | pIC50 | = | 7.7 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 20423349 | ||
3353 | 9149 | 0 | None | -41 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | ||
3412 | 9149 | 0 | None | -41 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | ||
6435286 | 9149 | 0 | None | -41 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | ||
CHEMBL1521056 | 9149 | 0 | None | -41 | 4 | Human | 8.2 | pIC50 | = | 8.2 | Functional | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | ||
10438479 | 8693 | 23 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 595 | 16 | 3 | 6 | 6.3 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOC1CCCCC1)C(=O)O | 20423349 | ||
6197 | 8693 | 23 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 595 | 16 | 3 | 6 | 6.3 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOC1CCCCC1)C(=O)O | 20423349 | ||
CHEMBL3342944 | 8693 | 23 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 595 | 16 | 3 | 6 | 6.3 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOC1CCCCC1)C(=O)O | 20423349 | ||
3354 | 9148 | 26 | None | -23 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10851239 | ||
3354 | 9148 | 26 | None | -23 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | ||
5280493 | 9148 | 26 | None | -23 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10851239 | ||
5280493 | 9148 | 26 | None | -23 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | ||
CHEMBL451509 | 9148 | 26 | None | -23 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10851239 | ||
CHEMBL451509 | 9148 | 26 | None | -23 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | ||
DB08855 | 9148 | 26 | None | -23 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10851239 | ||
DB08855 | 9148 | 26 | None | -23 | 4 | Human | 8.4 | pIC50 | = | 8.4 | Functional | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | ||
53394034 | 7375 | 22 | None | 21 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | Guide to Pharmacology | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 21903747 | ||
6196 | 7375 | 22 | None | 21 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | Guide to Pharmacology | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 21903747 | ||
CHEMBL3342945 | 7375 | 22 | None | 21 | 2 | Human | 6.9 | pIC50 | = | 6.9 | Functional | Guide to Pharmacology | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 21903747 | ||
10438479 | 8693 | 23 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | Guide to Pharmacology | 595 | 16 | 3 | 6 | 6.3 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOC1CCCCC1)C(=O)O | 20423349 | ||
6197 | 8693 | 23 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | Guide to Pharmacology | 595 | 16 | 3 | 6 | 6.3 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOC1CCCCC1)C(=O)O | 20423349 | ||
CHEMBL3342944 | 8693 | 23 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | Guide to Pharmacology | 595 | 16 | 3 | 6 | 6.3 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOC1CCCCC1)C(=O)O | 20423349 | ||
2237 | 9936 | 79 | None | -3630 | 10 | Human | 5.4 | pIC50 | = | 5.4 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10851239 | ||
3634 | 9936 | 79 | None | -3630 | 10 | Human | 5.4 | pIC50 | = | 5.4 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10851239 | ||
4887 | 9936 | 79 | None | -3630 | 10 | Human | 5.4 | pIC50 | = | 5.4 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10851239 | ||
CHEMBL21333 | 9936 | 79 | None | -3630 | 10 | Human | 5.4 | pIC50 | = | 5.4 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10851239 | ||
DB01411 | 9936 | 79 | None | -3630 | 10 | Human | 5.4 | pIC50 | = | 5.4 | Functional | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10851239 | ||
3381 | 7376 | 27 | None | -3 | 3 | Human | 6.6 | pKB | = | 6.6 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 1331415 | ||
5311015 | 7376 | 27 | None | -3 | 3 | Human | 6.6 | pKB | = | 6.6 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 1331415 | ||
CHEMBL285954 | 7376 | 27 | None | -3 | 3 | Human | 6.6 | pKB | = | 6.6 | Functional | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 1331415 |
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
2237 | 9936 | 79 | None | - | 3 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | |||
3634 | 9936 | 79 | None | - | 3 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | |||
4887 | 9936 | 79 | None | - | 3 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | |||
CHEMBL21333 | 9936 | 79 | None | - | 3 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | |||
DB01411 | 9936 | 79 | None | - | 3 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | |||
54746913 | 182290 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 412 | 5 | 3 | 6 | 1.5 | O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)cc3)c1=O)COC2 | 10.1021/acsmedchemlett.8b00274 | |||
CHEMBL4577928 | 182290 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 412 | 5 | 3 | 6 | 1.5 | O=C(O)CNC(=O)c1c(O)c2c(n(Cc3ccc(C(F)(F)F)cc3)c1=O)COC2 | 10.1021/acsmedchemlett.8b00274 | |||
2855 | 10904 | 104 | None | -776 | 6 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | |||
3322 | 10904 | 104 | None | -776 | 6 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | |||
5717 | 10904 | 104 | None | -776 | 6 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | |||
CHEMBL603 | 10904 | 104 | None | -776 | 6 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | |||
DB00549 | 10904 | 104 | None | -776 | 6 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | |||
115219 | 8759 | 14 | None | -251188 | 3 | Human | 5.2 | pKd | = | 5.2 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 1329767 | |||
3358 | 8759 | 14 | None | -251188 | 3 | Human | 5.2 | pKd | = | 5.2 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 1329767 | |||
3414 | 8759 | 14 | None | -251188 | 3 | Human | 5.2 | pKd | = | 5.2 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 1329767 | |||
CHEMBL22033 | 8759 | 14 | None | -251188 | 3 | Human | 5.2 | pKd | = | 5.2 | Binding | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 1329767 | |||
3353 | 9149 | 0 | None | -21 | 2 | Human | 8.4 | pKd | = | 8.4 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10851239 | |||
3412 | 9149 | 0 | None | -21 | 2 | Human | 8.4 | pKd | = | 8.4 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10851239 | |||
6435286 | 9149 | 0 | None | -21 | 2 | Human | 8.4 | pKd | = | 8.4 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10851239 | |||
CHEMBL1521056 | 9149 | 0 | None | -21 | 2 | Human | 8.4 | pKd | = | 8.4 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10851239 | |||
2855 | 10904 | 104 | 3H-LTD4 | -776 | 6 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
3322 | 10904 | 104 | 3H-LTD4 | -776 | 6 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
5717 | 10904 | 104 | 3H-LTD4 | -776 | 6 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
CHEMBL603 | 10904 | 104 | 3H-LTD4 | -776 | 6 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
DB00549 | 10904 | 104 | 3H-LTD4 | -776 | 6 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
None | 223000 | 0 | 3H-LTD4 | -95 | 2 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 514 | 11 | 1 | 5 | 6.5 | CN(C)C(=O)CCSC(C1=CC=CC(=C1)C=CC2=NC3=C(C=CC(=C3)Cl)C=C2)SCCC(=O)O | None | |||
57340263 | 222999 | 0 | 3H-LTD4 | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C/C=C/C=C/[C@H]([C@H](CCCC(=O)O)O)SC1=CC=C(C=C1)C(=O)O | None | |||
None | 222987 | 0 | 3H-LTD4 | -2187 | 4 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 473 | 7 | 2 | 3 | 7.9 | CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)S)O | None | |||
3352 | 9150 | 28 | None | -125 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 9547367 | |||
5280879 | 9150 | 28 | None | -125 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 9547367 | |||
5863 | 9150 | 28 | None | -125 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 9547367 | |||
CHEMBL509456 | 9150 | 28 | None | -125 | 3 | Human | 6.5 | pKi | = | 6.5 | Binding | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 9547367 | |||
3353 | 9149 | 0 | None | -21 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9547367 | |||
3412 | 9149 | 0 | None | -21 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9547367 | |||
6435286 | 9149 | 0 | None | -21 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9547367 | |||
CHEMBL1521056 | 9149 | 0 | None | -21 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9547367 | |||
1836 | 9370 | 59 | None | -2 | 15 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | |||
3340 | 9370 | 59 | None | -2 | 15 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | |||
5281040 | 9370 | 59 | None | -2 | 15 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | |||
CHEMBL787 | 9370 | 59 | None | -2 | 15 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | |||
DB00471 | 9370 | 59 | None | -2 | 15 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None |