Ligand source activities (1 row/activity)





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DOI

10367574 20717 0 None - 1 Guinea pig 9.5 pIC50 = 9.5 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 472 2 0 6 6.2 Cc1cn2c(n1)CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=Nc1cc(Cl)c(Cl)cc1-2 10.1021/jm00018a012
CHEMBL119660 20717 0 None - 1 Guinea pig 9.5 pIC50 = 9.5 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 472 2 0 6 6.2 Cc1cn2c(n1)CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=Nc1cc(Cl)c(Cl)cc1-2 10.1021/jm00018a012
10028664 170513 0 None - 1 Guinea pig 9.4 pIC50 = 9.4 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 493 3 0 7 5.6 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(C4CCCCC4)nn4c3N(CCCC4)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL420527 170513 0 None - 1 Guinea pig 9.4 pIC50 = 9.4 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 493 3 0 7 5.6 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(C4CCCCC4)nn4c3N(CCCC4)C(=O)C2)cc1 10.1021/jm00018a012
10479006 20365 0 None - 1 Guinea pig 9.3 pIC50 = 9.3 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 451 2 1 5 6.5 Cc1nc2cnccc2n1-c1ccc(C2=Nc3cc(Cl)c(Cl)cc3N=C(S)C2)cc1 10.1021/jm00018a011
CHEMBL119412 20365 0 None - 1 Guinea pig 9.3 pIC50 = 9.3 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 451 2 1 5 6.5 Cc1nc2cnccc2n1-c1ccc(C2=Nc3cc(Cl)c(Cl)cc3N=C(S)C2)cc1 10.1021/jm00018a011
10071745 117240 0 None - 1 Guinea pig 9.3 pIC50 = 9.3 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 436 2 1 4 5.7 Cc1nc2cnccc2n1-c1ccc(C2CC(=O)Nc3cc(Cl)c(Cl)cc3C2)cc1 10.1021/jm00018a011
CHEMBL324709 117240 0 None - 1 Guinea pig 9.3 pIC50 = 9.3 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 436 2 1 4 5.7 Cc1nc2cnccc2n1-c1ccc(C2CC(=O)Nc3cc(Cl)c(Cl)cc3C2)cc1 10.1021/jm00018a011
10478956 121755 0 None - 1 Guinea pig 9.3 pIC50 = 9.3 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 450 2 0 4 5.7 Cc1nc2cnccc2n1-c1ccc(C2CC(=O)N(C)c3cc(Cl)c(Cl)cc3C2)cc1 10.1021/jm00018a011
CHEMBL334275 121755 0 None - 1 Guinea pig 9.3 pIC50 = 9.3 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 450 2 0 4 5.7 Cc1nc2cnccc2n1-c1ccc(C2CC(=O)N(C)c3cc(Cl)c(Cl)cc3C2)cc1 10.1021/jm00018a011
10322057 20300 0 None - 1 Guinea pig 9.3 pIC50 = 9.3 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 461 3 0 7 4.6 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(-c4ccccc4)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL119371 20300 0 None - 1 Guinea pig 9.3 pIC50 = 9.3 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 461 3 0 7 4.6 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(-c4ccccc4)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL106908 12126 0 None - 1 Guinea pig 9.3 pIC50 = 9.3 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 586 9 1 9 6.3 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)N=C(C)/C(=C(/O)OCCOC)C1c1ccccc1Cl 10.1021/jm00095a005
10024618 175069 0 None - 1 Guinea pig 9.2 pIC50 = 9.2 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 411 2 1 5 5.8 Cc1cc2c(cc1C)N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)CC(S)=N2 10.1021/jm00018a011
CHEMBL434028 175069 0 None - 1 Guinea pig 9.2 pIC50 = 9.2 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 411 2 1 5 5.8 Cc1cc2c(cc1C)N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)CC(S)=N2 10.1021/jm00018a011
10458486 117139 0 None - 1 Guinea pig 9.2 pIC50 = 9.2 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 495 3 0 7 5.3 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(-c4ccc(Cl)cc4)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL324121 117139 0 None - 1 Guinea pig 9.2 pIC50 = 9.2 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 495 3 0 7 5.3 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(-c4ccc(Cl)cc4)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
135507267 118145 0 None - 1 Guinea pig 9.2 pIC50 = 9.2 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 447 3 1 7 4.6 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(-c4ccccc4)nn(C)c3NC(=O)C2)cc1 10.1021/jm00018a012
CHEMBL327034 118145 0 None - 1 Guinea pig 9.2 pIC50 = 9.2 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 447 3 1 7 4.6 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(-c4ccccc4)nn(C)c3NC(=O)C2)cc1 10.1021/jm00018a012
10453303 120095 0 None - 1 Guinea pig 9.2 pIC50 = 9.2 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 395 2 1 5 4.8 Cc1cc2c(cc1C)NC(=O)CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a011
CHEMBL331566 120095 0 None - 1 Guinea pig 9.2 pIC50 = 9.2 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 395 2 1 5 4.8 Cc1cc2c(cc1C)NC(=O)CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a011
10027595 20714 0 None - 1 Guinea pig 9.2 pIC50 = 9.2 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 467 3 0 7 5.0 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(C4CCCCC4)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL119659 20714 0 None - 1 Guinea pig 9.2 pIC50 = 9.2 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 467 3 0 7 5.0 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(C4CCCCC4)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
11754521 20373 0 None - 1 Guinea pig 9.1 pIC50 = 9.1 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 471 6 0 8 4.1 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(COCC(C)C)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL119417 20373 0 None - 1 Guinea pig 9.1 pIC50 = 9.1 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 471 6 0 8 4.1 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(COCC(C)C)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
10003131 16874 0 None - 1 Guinea pig 9.1 pIC50 = 9.1 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 435 2 1 5 5.5 Cc1nc2cnccc2n1-c1ccc(C2=Nc3cc(Cl)c(Cl)cc3NC(=O)C2)cc1 10.1021/jm00018a011
CHEMBL115529 16874 0 None - 1 Guinea pig 9.1 pIC50 = 9.1 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 435 2 1 5 5.5 Cc1nc2cnccc2n1-c1ccc(C2=Nc3cc(Cl)c(Cl)cc3NC(=O)C2)cc1 10.1021/jm00018a011
10068655 174732 0 None - 1 Guinea pig 9.0 pIC50 = 9 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 385 2 1 7 3.2 Cc1nn(C)c2c1NC(=O)CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a012
CHEMBL431664 174732 0 None - 1 Guinea pig 9.0 pIC50 = 9 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 385 2 1 7 3.2 Cc1nn(C)c2c1NC(=O)CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a012
10367575 68613 0 None - 1 Guinea pig 8.9 pIC50 = 8.9 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 472 2 0 6 6.2 Cc1cnc2n1-c1cc(Cl)c(Cl)cc1N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)C2 10.1021/jm00018a012
CHEMBL177351 68613 0 None - 1 Guinea pig 8.9 pIC50 = 8.9 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 472 2 0 6 6.2 Cc1cnc2n1-c1cc(Cl)c(Cl)cc1N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)C2 10.1021/jm00018a012
10386862 17827 0 None - 1 Guinea pig 8.9 pIC50 = 8.9 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 410 2 0 6 4.2 Cc1cc(C)c2c(n1)N(C)C(=O)CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a012
CHEMBL117733 17827 0 None - 1 Guinea pig 8.9 pIC50 = 8.9 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 410 2 0 6 4.2 Cc1cc(C)c2c(n1)N(C)C(=O)CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a012
10341961 20233 0 None - 1 Guinea pig 8.9 pIC50 = 8.9 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 418 2 0 6 5.2 Cc1cc2c(cc1C)-n1ccnc1CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a012
CHEMBL119317 20233 0 None - 1 Guinea pig 8.9 pIC50 = 8.9 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 418 2 0 6 5.2 Cc1cc2c(cc1C)-n1ccnc1CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a012
CHEMBL318172 114209 0 None - 1 Guinea pig 8.9 pIC50 = 8.9 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 584 6 1 8 7.5 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)N=C(C)/C(=C(/O)OC(C)(C)C)C1c1ccccc1Cl 10.1021/jm00095a005
10004469 174711 0 None - 1 Guinea pig 8.9 pIC50 = 8.9 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 460 2 0 6 4.4 Cc1nc2cnccc2n1-c1ccc(C2=Nc3cc(Br)cnc3N(C)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL431470 174711 0 None - 1 Guinea pig 8.9 pIC50 = 8.9 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 460 2 0 6 4.4 Cc1nc2cnccc2n1-c1ccc(C2=Nc3cc(Br)cnc3N(C)C(=O)C2)cc1 10.1021/jm00018a012
10096132 121365 0 None - 1 Guinea pig 8.8 pIC50 = 8.8 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 467 3 0 8 4.7 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(-c4cccs4)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL333780 121365 0 None - 1 Guinea pig 8.8 pIC50 = 8.8 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 467 3 0 8 4.7 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(-c4cccs4)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL106350 12023 0 None - 1 Guinea pig 8.8 pIC50 = 8.8 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 542 6 1 8 6.3 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)N=C(C)/C(=C(/O)OC)C1c1ccccc1Cl 10.1021/jm00095a005
10095715 20402 0 None - 1 Guinea pig 8.8 pIC50 = 8.8 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 458 2 0 6 5.9 Cc1nc2cnccc2n1-c1ccc(C2=Nc3cc(Cl)c(Cl)cc3-n3ccnc3C2)cc1 10.1021/jm00018a012
CHEMBL119439 20402 0 None - 1 Guinea pig 8.8 pIC50 = 8.8 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 458 2 0 6 5.9 Cc1nc2cnccc2n1-c1ccc(C2=Nc3cc(Cl)c(Cl)cc3-n3ccnc3C2)cc1 10.1021/jm00018a012
15005338 12041 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 564 7 2 6 6.7 CCOC(=O)C1=C(c2ccc(-c3cccnc3C)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL106475 12041 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 564 7 2 6 6.7 CCOC(=O)C1=C(c2ccc(-c3cccnc3C)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
10340604 20297 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 394 2 1 6 4.9 Cc1cc2c(cc1C)N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)CC(N)=N2 10.1021/jm00018a011
CHEMBL119366 20297 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 394 2 1 6 4.9 Cc1cc2c(cc1C)N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)CC(N)=N2 10.1021/jm00018a011
10024561 20191 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 410 5 0 4 3.8 CC(C(=O)N1CCN(C(C#N)c2cccnc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm00100a018
CHEMBL1192837 20191 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 410 5 0 4 3.8 CC(C(=O)N1CCN(C(C#N)c2cccnc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm00100a018
CHEMBL3216197 20191 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 410 5 0 4 3.8 CC(C(=O)N1CCN(C(C#N)c2cccnc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm00100a018
10319288 114074 0 None - 1 Guinea pig 8.0 pIC50 = 8 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 408 5 0 4 3.9 N#CC(c1cccnc1)N1CCN(C(=O)C=C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL317193 114074 0 None - 1 Guinea pig 8.0 pIC50 = 8 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 408 5 0 4 3.9 N#CC(c1cccnc1)N1CCN(C(=O)C=C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
9978062 122266 0 None - 1 Guinea pig 8.0 pIC50 = 8 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 396 5 0 4 3.6 N#CC(c1cccnc1)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL335113 122266 0 None - 1 Guinea pig 8.0 pIC50 = 8 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 396 5 0 4 3.6 N#CC(c1cccnc1)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
15005355 116658 0 None - 1 Guinea pig 8.0 pIC50 = 8 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 584 7 2 7 7.0 CCOC(=O)C1=C(c2ccc(-c3sc(C)nc3C)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL323429 116658 0 None - 1 Guinea pig 8.0 pIC50 = 8 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 584 7 2 7 7.0 CCOC(=O)C1=C(c2ccc(-c3sc(C)nc3C)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
10319288 114074 0 None - 1 Guinea pig 8.0 pIC50 = 8 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 408 5 0 4 3.9 N#CC(c1cccnc1)N1CCN(C(=O)C=C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL317193 114074 0 None - 1 Guinea pig 8.0 pIC50 = 8 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 408 5 0 4 3.9 N#CC(c1cccnc1)N1CCN(C(=O)C=C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
11765208 19003 0 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 539 20 0 4 7.7 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2CCC)C(C)=O)cc1OC 10.1021/jm00057a008
CHEMBL1184447 19003 0 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 539 20 0 4 7.7 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2CCC)C(C)=O)cc1OC 10.1021/jm00057a008
CHEMBL349327 19003 0 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 539 20 0 4 7.7 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2CCC)C(C)=O)cc1OC 10.1021/jm00057a008
131088 104003 5 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 588 10 0 10 3.3 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)C(C)(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL268596 104003 5 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 588 10 0 10 3.3 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)C(C)(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
3075907 104082 4 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 617 13 1 10 3.6 CCCC(C)NC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL269133 104082 4 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 617 13 1 10 3.6 CCCC(C)NC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
462400 104083 4 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 617 11 1 10 3.5 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)NCC(C)(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL269134 104083 4 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 617 11 1 10 3.5 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)NCC(C)(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
19829358 18468 0 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 598 24 1 7 7.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1csc[n+]1C)C(C)=O)OC 10.1021/jm00121a012
CHEMBL1181209 18468 0 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 598 24 1 7 7.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1csc[n+]1C)C(C)=O)OC 10.1021/jm00121a012
CHEMBL159007 18468 0 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 598 24 1 7 7.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1csc[n+]1C)C(C)=O)OC 10.1021/jm00121a012
14885631 41714 0 None - 1 Human 6.0 pIC50 = 6 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 332 0 0 2 3.9 CC(=O)N1CCC(=C2c3ccc(C)cc3CCc3cccnc32)CC1 10.1021/jm00105a069
CHEMBL143242 41714 0 None - 1 Human 6.0 pIC50 = 6 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 332 0 0 2 3.9 CC(=O)N1CCC(=C2c3ccc(C)cc3CCc3cccnc32)CC1 10.1021/jm00105a069
14554146 125897 0 None - 1 Human 6.0 pIC50 = 6 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 354 0 0 2 3.9 CC(=O)N1CCC(=C2c3cc(F)c(F)cc3CCc3cccnc32)CC1 10.1021/jm00105a069
CHEMBL342747 125897 0 None - 1 Human 6.0 pIC50 = 6 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 354 0 0 2 3.9 CC(=O)N1CCC(=C2c3cc(F)c(F)cc3CCc3cccnc32)CC1 10.1021/jm00105a069
10348471 18433 0 None - 1 Guinea pig 6.0 pIC50 = 6 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 467 18 0 2 7.1 CCCCCCCCCCCCCCOc1ccc(CN(Cc2cc[n+](C)cc2)C(C)=O)cc1 10.1021/jm00057a008
CHEMBL1181099 18433 0 None - 1 Guinea pig 6.0 pIC50 = 6 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 467 18 0 2 7.1 CCCCCCCCCCCCCCOc1ccc(CN(Cc2cc[n+](C)cc2)C(C)=O)cc1 10.1021/jm00057a008
CHEMBL155590 18433 0 None - 1 Guinea pig 6.0 pIC50 = 6 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 467 18 0 2 7.1 CCCCCCCCCCCCCCOc1ccc(CN(Cc2cc[n+](C)cc2)C(C)=O)cc1 10.1021/jm00057a008
10326369 18428 0 None - 1 Guinea pig 5.0 pIC50 = 5 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 481 13 0 3 6.5 CCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2C)C(C)=O)cc1C(C)(C)C 10.1021/jm00057a008
CHEMBL1181069 18428 0 None - 1 Guinea pig 5.0 pIC50 = 5 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 481 13 0 3 6.5 CCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2C)C(C)=O)cc1C(C)(C)C 10.1021/jm00057a008
CHEMBL154537 18428 0 None - 1 Guinea pig 5.0 pIC50 = 5 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 481 13 0 3 6.5 CCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2C)C(C)=O)cc1C(C)(C)C 10.1021/jm00057a008
14785938 18944 0 None - 1 Guinea pig 5.0 pIC50 = 5 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 526 25 0 4 8.0 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCC[N+]2(C)CCOCC2)O1 10.1021/jm00105a058
CHEMBL1184208 18944 0 None - 1 Guinea pig 5.0 pIC50 = 5 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 526 25 0 4 8.0 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCC[N+]2(C)CCOCC2)O1 10.1021/jm00105a058
CHEMBL339006 18944 0 None - 1 Guinea pig 5.0 pIC50 = 5 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 526 25 0 4 8.0 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCC[N+]2(C)CCOCC2)O1 10.1021/jm00105a058
44268122 17900 0 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL1178068 17900 0 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL12439 17900 0 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL12882 17900 0 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
10258772 168627 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 656 13 0 11 3.5 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)COc3ccc(F)cc3)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL414696 168627 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 656 13 0 11 3.5 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)COc3ccc(F)cc3)C2)cc(OC)c1OC 10.1021/jm00060a006
14992435 175972 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 575 19 0 7 7.6 CCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1OC 10.1021/jm00087a023
CHEMBL440663 175972 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 575 19 0 7 7.6 CCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1OC 10.1021/jm00087a023
44267856 17711 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 616 26 1 7 8.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COP(=O)([O-])OCC[n+]2ccsc2)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL11731 17711 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 616 26 1 7 8.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COP(=O)([O-])OCC[n+]2ccsc2)CCCC1 10.1016/0960-894X(95)00173-Q
10048003 20290 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 424 7 0 4 3.9 N#CC(c1cccnc1)N1CCN(C(=O)C(Cc2ccccc2)Cc2ccccc2)CC1 10.1021/jm00100a018
CHEMBL1193633 20290 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 424 7 0 4 3.9 N#CC(c1cccnc1)N1CCN(C(=O)C(Cc2ccccc2)Cc2ccccc2)CC1 10.1021/jm00100a018
CHEMBL3216401 20290 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 424 7 0 4 3.9 N#CC(c1cccnc1)N1CCN(C(=O)C(Cc2ccccc2)Cc2ccccc2)CC1 10.1021/jm00100a018
44344947 170664 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 420 2 0 8 4.0 Cc1cc2c(cc1C)-n1nnnc1CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a012
CHEMBL420697 170664 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 420 2 0 8 4.0 Cc1cc2c(cc1C)-n1nnnc1CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a012
20066875 18459 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 589 24 0 5 8.2 CCCCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL1181185 18459 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 589 24 0 5 8.2 CCCCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL158384 18459 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 589 24 0 5 8.2 CCCCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
10407257 11500 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 377 6 1 5 2.5 CNC(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccccc1 10.1021/jm00072a019
CHEMBL103596 11500 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 377 6 1 5 2.5 CNC(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccccc1 10.1021/jm00072a019
107757 8005 3 None -4 2 Guinea pig 8.0 pIC50 = 8.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1021/jm00105a058
1852 8005 3 None -4 2 Guinea pig 8.0 pIC50 = 8.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1021/jm00105a058
CHEMBL1180101 8005 3 None -4 2 Guinea pig 8.0 pIC50 = 8.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1021/jm00105a058
44350001 18238 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL1180380 18238 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL124534 18238 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL127678 18238 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL104978 11763 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 577 10 2 8 6.1 CCO/C(O)=C1\C(COCCn2c(C)nc(C)c2C)=NC(C)=C(C(=O)Nc2cccc(C)n2)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
44371923 18479 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 634 27 1 6 8.3 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1cccc[n+]1CCCC)C(C)=O)OC 10.1021/jm00121a012
CHEMBL1181243 18479 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 634 27 1 6 8.3 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1cccc[n+]1CCCC)C(C)=O)OC 10.1021/jm00121a012
CHEMBL160530 18479 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 634 27 1 6 8.3 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1cccc[n+]1CCCC)C(C)=O)OC 10.1021/jm00121a012
14785994 18254 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 535 20 0 6 5.9 CCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL1180405 18254 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 535 20 0 6 5.9 CCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL125465 18254 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 535 20 0 6 5.9 CCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
10484537 18424 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 537 17 0 3 8.1 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cc[n+](C)cc2)C(C)=O)cc1C(C)(C)C 10.1021/jm00057a008
CHEMBL1181064 18424 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 537 17 0 3 8.1 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cc[n+](C)cc2)C(C)=O)cc1C(C)(C)C 10.1021/jm00057a008
CHEMBL154459 18424 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 537 17 0 3 8.1 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cc[n+](C)cc2)C(C)=O)cc1C(C)(C)C 10.1021/jm00057a008
19829284 18736 1 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 598 25 1 6 7.2 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+]1(C)CCCC1)C(C)=O)OC 10.1021/jm00121a012
CHEMBL1182953 18736 1 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 598 25 1 6 7.2 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+]1(C)CCCC1)C(C)=O)OC 10.1021/jm00121a012
CHEMBL273776 18736 1 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 598 25 1 6 7.2 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+]1(C)CCCC1)C(C)=O)OC 10.1021/jm00121a012
14785912 18253 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 524 24 0 5 8.1 CCCCCCCCCCCCCCCCCC1OCC(COC(=O)CCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL1180403 18253 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 524 24 0 5 8.1 CCCCCCCCCCCCCCCCCC1OCC(COC(=O)CCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL125419 18253 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 524 24 0 5 8.1 CCCCCCCCCCCCCCCCCC1OCC(COC(=O)CCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
14785902 18291 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 482 23 0 4 7.3 CCCCCCCCCCCCOCC1COC(COCCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL1180485 18291 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 482 23 0 4 7.3 CCCCCCCCCCCCOCC1COC(COCCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL127746 18291 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 482 23 0 4 7.3 CCCCCCCCCCCCOCC1COC(COCCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
14785884 18958 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 494 24 0 3 8.9 CCCCCCCCCCCCCCC1COC(COCCCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL1184240 18958 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 494 24 0 3 8.9 CCCCCCCCCCCCCCC1COC(COCCCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL340489 18958 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 494 24 0 3 8.9 CCCCCCCCCCCCCCC1COC(COCCCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
10095482 28932 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 454 7 0 5 4.5 N#CC(c1cccc([N+](=O)[O-])c1)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL132246 28932 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 454 7 0 5 4.5 N#CC(c1cccc([N+](=O)[O-])c1)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
10048604 122045 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 435 6 0 4 3.1 O=C(CC(c1ccccc1)c1ccccc1)N1CCN(S(=O)(=O)c2ccncc2)CC1 10.1021/jm00100a018
CHEMBL334852 122045 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 435 6 0 4 3.1 O=C(CC(c1ccccc1)c1ccccc1)N1CCN(S(=O)(=O)c2ccncc2)CC1 10.1021/jm00100a018
44349949 18968 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 567 25 1 7 7.1 CCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)CCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL1184258 18968 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 567 25 1 7 7.1 CCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)CCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL341513 18968 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 567 25 1 7 7.1 CCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)CCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
20066784 23603 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 532 21 0 6 7.5 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2ccccn2)C(C)=O)C1 10.1021/jm00105a058
CHEMBL124747 23603 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 532 21 0 6 7.5 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2ccccn2)C(C)=O)C1 10.1021/jm00105a058
5556 210039 27 None -26 5 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 342 1 0 4 4.2 Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00057a008
CHEMBL646 210039 27 None -26 5 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 342 1 0 4 4.2 Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00057a008
21463389 18745 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 593 26 1 5 9.3 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCC[n+]2ccsc2)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL1183002 18745 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 593 26 1 5 9.3 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCC[n+]2ccsc2)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL275573 18745 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 593 26 1 5 9.3 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCC[n+]2ccsc2)CCCC1 10.1016/0960-894X(95)00173-Q
10439610 209654 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 687 18 0 10 5.5 CCCCCN(CCCCC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL6263 209654 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 687 18 0 10 5.5 CCCCCN(CCCCC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
14992437 176866 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 603 21 0 7 8.4 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1OC 10.1021/jm00087a023
CHEMBL44434 176866 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 603 21 0 7 8.4 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1OC 10.1021/jm00087a023
21463481 17892 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 616 24 1 5 8.6 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178051 17892 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 616 24 1 5 8.6 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCC1 10.1016/0960-894X(95)00173-Q
CHEMBL12119 17892 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 616 24 1 5 8.6 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCC1 10.1016/0960-894X(95)00173-Q
10415640 18088 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 444 13 0 5 5.1 CCCCCCOc1c(OC)cc(C(=O)Oc2ccc(CC[N+](C)(C)C)cc2)cc1OC 10.1021/jm00012a012
CHEMBL1179323 18088 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 444 13 0 5 5.1 CCCCCCOc1c(OC)cc(C(=O)Oc2ccc(CC[N+](C)(C)C)cc2)cc1OC 10.1021/jm00012a012
CHEMBL70229 18088 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 444 13 0 5 5.1 CCCCCCOc1c(OC)cc(C(=O)Oc2ccc(CC[N+](C)(C)C)cc2)cc1OC 10.1021/jm00012a012
14992463 178007 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 709 20 0 6 11.0 CCCCCCCCCCCCCCOc1c(Cl)c(Cl)c(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(Cl)c1Cl 10.1021/jm00087a023
CHEMBL44597 178007 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 709 20 0 6 11.0 CCCCCCCCCCCCCCOc1c(Cl)c(Cl)c(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(Cl)c1Cl 10.1021/jm00087a023
44268190 18721 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 655 24 0 6 9.2 CCCCCCCCCCCCCCCCOC[C@@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(=O)c2ccc(OC)cc2)S1 10.1016/0960-894X(95)00174-R
CHEMBL1182836 18721 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 655 24 0 6 9.2 CCCCCCCCCCCCCCCCOC[C@@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(=O)c2ccc(OC)cc2)S1 10.1016/0960-894X(95)00174-R
CHEMBL268965 18721 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 655 24 0 6 9.2 CCCCCCCCCCCCCCCCOC[C@@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(=O)c2ccc(OC)cc2)S1 10.1016/0960-894X(95)00174-R
107757 8005 3 None -4 2 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1021/jm00082a007
1852 8005 3 None -4 2 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1021/jm00082a007
CHEMBL1180101 8005 3 None -4 2 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1021/jm00082a007
15005341 12165 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 568 7 2 8 5.5 CCOC(=O)C1=C(c2ccc(-n3c(C)nnc3C)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL107113 12165 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 568 7 2 8 5.5 CCOC(=O)C1=C(c2ccc(-n3c(C)nnc3C)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
10364589 11504 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 416 5 0 4 3.8 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)C(F)(F)F)CC1 10.1021/jm00072a019
CHEMBL103636 11504 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 416 5 0 4 3.8 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)C(F)(F)F)CC1 10.1021/jm00072a019
10051215 11461 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 489 6 1 6 3.6 COC(=O)NC(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccc(C(F)(F)F)cc1 10.1021/jm00072a019
CHEMBL103393 11461 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 489 6 1 6 3.6 COC(=O)NC(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccc(C(F)(F)F)cc1 10.1021/jm00072a019
107757 8005 3 None -4 2 Guinea pig 7.9 pIC50 = 7.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1021/jm00105a058
1852 8005 3 None -4 2 Guinea pig 7.9 pIC50 = 7.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1021/jm00105a058
CHEMBL1180101 8005 3 None -4 2 Guinea pig 7.9 pIC50 = 7.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1021/jm00105a058
10454455 215219 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 414 4 0 4 3.7 Cc1ncccc1C(C#N)N1CCN(C(=O)/C=C(/c2ccccc2)C(F)(F)F)CC1 10.1021/jm00072a019
CHEMBL99966 215219 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 414 4 0 4 3.7 Cc1ncccc1C(C#N)N1CCN(C(=O)/C=C(/c2ccccc2)C(F)(F)F)CC1 10.1021/jm00072a019
10004065 11044 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 453 8 1 5 3.9 Cc1ncccc1C(C#N)N1CCN(C(=O)CCNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL100597 11044 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 453 8 1 5 3.9 Cc1ncccc1C(C#N)N1CCN(C(=O)CCNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
131088 104003 5 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 588 10 0 10 3.3 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)C(C)(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL268596 104003 5 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 588 10 0 10 3.3 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)C(C)(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
3075904 209590 6 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 602 11 0 10 3.7 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)CC(C)(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL6232 209590 6 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 602 11 0 10 3.7 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)CC(C)(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
10347147 105414 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.
ChEMBL 537 27 0 7 5.7 CCCCCCCCCCCC(=O)CCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)OC 10.1021/jm00007a018
CHEMBL277186 105414 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.
ChEMBL 537 27 0 7 5.7 CCCCCCCCCCCC(=O)CCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)OC 10.1021/jm00007a018
10022991 30531 2 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 385 5 0 3 4.1 CC(c1cccnc1)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL133565 30531 2 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 385 5 0 3 4.1 CC(c1cccnc1)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
14785924 17909 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 498 24 0 5 7.1 CCCCCCCCCCCCCCCCOCC1OCC(COCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL1178191 17909 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 498 24 0 5 7.1 CCCCCCCCCCCCCCCCOCC1OCC(COCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL14604 17909 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 498 24 0 5 7.1 CCCCCCCCCCCCCCCCOCC1OCC(COCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
10255055 18834 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 364 12 0 3 4.9 CCCCCCOc1c(C)cc(C(=O)OCCCC[N+](C)(C)C)cc1C 10.1021/jm00012a012
CHEMBL1183615 18834 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 364 12 0 3 4.9 CCCCCCOc1c(C)cc(C(=O)OCCCC[N+](C)(C)C)cc1C 10.1021/jm00012a012
CHEMBL307760 18834 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 364 12 0 3 4.9 CCCCCCOc1c(C)cc(C(=O)OCCCC[N+](C)(C)C)cc1C 10.1021/jm00012a012
14992317 108113 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 583 25 0 7 7.5 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2ccsc2)c1)OC 10.1021/jm00087a023
CHEMBL296785 108113 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 583 25 0 7 7.5 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2ccsc2)c1)OC 10.1021/jm00087a023
14992503 108225 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 589 21 0 7 8.1 CCCCCCCCCCCCCCOc1cc(OC)cc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1 10.1021/jm00087a023
CHEMBL297623 108225 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 589 21 0 7 8.1 CCCCCCCCCCCCCCOc1cc(OC)cc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1 10.1021/jm00087a023
14992427 185945 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 585 20 0 5 9.1 CCCCCCCCCCCCCCc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(CC)c1 10.1021/jm00087a023
CHEMBL47219 185945 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 585 20 0 5 9.1 CCCCCCCCCCCCCCc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(CC)c1 10.1021/jm00087a023
21463443 17886 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 618 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178039 17886 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 618 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL11872 17886 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 618 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL12352 17886 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 618 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
10078097 209780 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 659 16 0 10 4.7 CCCCN(CCCC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL6319 209780 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 659 16 0 10 4.7 CCCCN(CCCC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
14950809 103847 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 418 8 0 8 3.1 COc1cc(N2CCN(c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL267229 103847 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 418 8 0 8 3.1 COc1cc(N2CCN(c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC 10.1021/jm00060a006
21463406 19139 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 524 25 0 5 7.7 CCCCCCCCCCCCCCCCOCC1(COC(=O)CCCCC[n+]2ccsc2)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL1185494 19139 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 524 25 0 5 7.7 CCCCCCCCCCCCCCCCOCC1(COC(=O)CCCCC[n+]2ccsc2)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL417432 19139 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 524 25 0 5 7.7 CCCCCCCCCCCCCCCCOCC1(COC(=O)CCCCC[n+]2ccsc2)COC1 10.1016/0960-894X(95)00173-Q
21463420 21432 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 610 26 1 6 8.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COP(=O)([O-])OCC[n+]2ccccc2)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL12055 21432 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 610 26 1 6 8.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COP(=O)([O-])OCC[n+]2ccccc2)CCCC1 10.1016/0960-894X(95)00173-Q
14992377 185312 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 560 25 0 6 7.4 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[S+](C)C)c1)OC 10.1021/jm00087a023
CHEMBL46682 185312 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 560 25 0 6 7.4 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[S+](C)C)c1)OC 10.1021/jm00087a023
132115 18491 1 None -1 2 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 575 23 0 5 8.1 CCCCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL1181271 18491 1 None -1 2 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 575 23 0 5 8.1 CCCCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL161096 18491 1 None -1 2 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 575 23 0 5 8.1 CCCCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL290840 18491 1 None -1 2 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 575 23 0 5 8.1 CCCCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
15005378 12101 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 605 7 2 9 5.7 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1cccnc1Cl 10.1021/jm00095a005
CHEMBL106800 12101 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 605 7 2 9 5.7 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1cccnc1Cl 10.1021/jm00095a005
15005336 12661 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 567 7 2 7 6.1 CCOC(=O)C1=C(c2ccc(-n3cc(C)nc3C)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL107951 12661 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 567 7 2 7 6.1 CCOC(=O)C1=C(c2ccc(-n3cc(C)nc3C)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
10072623 11475 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 453 7 1 5 3.9 Cc1ncccc1C(C#N)N1CCN(C(=O)[C@H](C)NC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL103476 11475 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 453 7 1 5 3.9 Cc1ncccc1C(C#N)N1CCN(C(=O)[C@H](C)NC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
9997078 31121 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 335 5 1 5 1.9 N#CC(c1cccnc1)N1CCN(C(=O)CNc2ccccc2)CC1 10.1021/jm00100a018
CHEMBL134094 31121 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 335 5 1 5 1.9 N#CC(c1cccnc1)N1CCN(C(=O)CNc2ccccc2)CC1 10.1021/jm00100a018
11726514 117401 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 368 2 1 6 3.6 Cc1nc2cnccc2n1-c1ccc(C2=Nc3cccnc3NC(=O)C2)cc1 10.1021/jm00018a012
CHEMBL325700 117401 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 368 2 1 6 3.6 Cc1nc2cnccc2n1-c1ccc(C2=Nc3cccnc3NC(=O)C2)cc1 10.1021/jm00018a012
11755085 11163 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 484 7 2 7 2.8 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)c2ncccc2O)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL101342 11163 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 484 7 2 7 2.8 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)c2ncccc2O)c2ccccc2)CC1 10.1021/jm00072a019
44290727 179783 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 643 18 0 6 9.9 CCCCCCCCCCCCOc1cc(C(C)(C)C)c(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c(C(C)(C)C)c1 10.1021/jm00087a023
CHEMBL45182 179783 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 643 18 0 6 9.9 CCCCCCCCCCCCOc1cc(C(C)(C)C)c(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c(C(C)(C)C)c1 10.1021/jm00087a023
3075905 146963 4 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 617 13 1 10 3.6 CCC(CC)NC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL380444 146963 4 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 617 13 1 10 3.6 CCC(CC)NC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
457881 209835 3 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 603 10 1 10 3.2 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)NC(C)(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL6359 209835 3 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 603 10 1 10 3.2 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)NC(C)(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
10453683 20135 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 401 5 0 6 2.2 COc1cc(C(=O)N2CCN(C(=S)c3cccnc3)CC2)cc(OC)c1OC 10.1021/jm00100a018
CHEMBL1192429 20135 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 401 5 0 6 2.2 COc1cc(C(=O)N2CCN(C(=S)c3cccnc3)CC2)cc(OC)c1OC 10.1021/jm00100a018
CHEMBL543662 20135 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 401 5 0 6 2.2 COc1cc(C(=O)N2CCN(C(=S)c3cccnc3)CC2)cc(OC)c1OC 10.1021/jm00100a018
14785926 18295 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 526 26 0 5 7.9 CCCCCCCCCCCCCCCCOCC1OCC(COCCCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL1180490 18295 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 526 26 0 5 7.9 CCCCCCCCCCCCCCCCOCC1OCC(COCCCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL127875 18295 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 526 26 0 5 7.9 CCCCCCCCCCCCCCCCOCC1OCC(COCCCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
14785859 18933 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 480 23 0 3 8.6 CCCCCCCCCCCCCCCC1CCC(COCCCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL1184194 18933 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 480 23 0 3 8.6 CCCCCCCCCCCCCCCC1CCC(COCCCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL338476 18933 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 480 23 0 3 8.6 CCCCCCCCCCCCCCCC1CCC(COCCCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
14554138 117439 37 None - 1 Human 4.9 pIC50 = 4.9 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 338 1 0 2 3.9 O=CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 10.1021/jm00105a069
CHEMBL325909 117439 37 None - 1 Human 4.9 pIC50 = 4.9 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 338 1 0 2 3.9 O=CN1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 10.1021/jm00105a069
14992383 176022 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 611 25 0 7 8.1 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2csc(C)c2C)c1)OC 10.1021/jm00087a023
CHEMBL44110 176022 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 611 25 0 7 8.1 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2csc(C)c2C)c1)OC 10.1021/jm00087a023
14992471 185537 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 601 21 0 7 8.3 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1C(C)=O 10.1021/jm00087a023
CHEMBL46870 185537 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 601 21 0 7 8.3 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1C(C)=O 10.1021/jm00087a023
10430573 170115 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 391 13 0 5 6.0 CCCCCCOc1c(OC)cc(CCCCc2scnc2C)cc1OC 10.1021/jm00012a012
CHEMBL419071 170115 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 391 13 0 5 6.0 CCCCCCOc1c(OC)cc(CCCCc2scnc2C)cc1OC 10.1021/jm00012a012
14992380 18810 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 761 28 1 5 11.2 CCCCCCCCCCCCCCCCOCC(COP(=O)(O)Oc1cccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)c1)OC 10.1021/jm00087a023
CHEMBL1183410 18810 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 761 28 1 5 11.2 CCCCCCCCCCCCCCCCOCC(COP(=O)(O)Oc1cccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)c1)OC 10.1021/jm00087a023
CHEMBL295434 18810 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 761 28 1 5 11.2 CCCCCCCCCCCCCCCCOCC(COP(=O)(O)Oc1cccc(C[P+](c2ccccc2)(c2ccccc2)c2ccccc2)c1)OC 10.1021/jm00087a023
44268192 18732 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 721 25 1 6 8.8 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)N1C(=O)c1ccccc1 10.1016/0960-894X(95)00174-R
CHEMBL1182943 18732 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 721 25 1 6 8.8 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)N1C(=O)c1ccccc1 10.1016/0960-894X(95)00174-R
CHEMBL273638 18732 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 721 25 1 6 8.8 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)N1C(=O)c1ccccc1 10.1016/0960-894X(95)00174-R
9985049 18071 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 424 16 0 5 5.1 CCCCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL1179246 18071 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 424 16 0 5 5.1 CCCCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL66234 18071 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 424 16 0 5 5.1 CCCCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
3075900 103863 4 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 713 14 1 13 4.0 COc1cc(NC(=O)OCC2CN(C(=O)c3cc(OC)c(OC)c(OC)c3)CCN2C(=O)c2cc(OC)c(OC)c(OC)c2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL267357 103863 4 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 713 14 1 13 4.0 COc1cc(NC(=O)OCC2CN(C(=O)c3cc(OC)c(OC)c(OC)c3)CCN2C(=O)c2cc(OC)c(OC)c(OC)c2)cc(OC)c1OC 10.1021/jm00060a006
10070445 17197 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 415 3 1 8 2.4 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(CO)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL116325 17197 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 415 3 1 8 2.4 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(CO)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
10049978 18748 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 462 3 0 8 4.0 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(-c4ccccn4)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL118302 18748 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 462 3 0 8 4.0 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(-c4ccccn4)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
15005366 13235 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 528 6 2 7 5.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)O)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL108260 13235 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 528 6 2 7 5.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)O)C1c1ccccc1Cl 10.1021/jm00095a005
15005376 117725 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 571 7 2 9 5.1 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccn1 10.1021/jm00095a005
CHEMBL326201 117725 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 571 7 2 9 5.1 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccn1 10.1021/jm00095a005
10002913 11094 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 432 5 1 5 2.9 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(O)(c2ccccc2)C(F)(F)F)CC1 10.1021/jm00072a019
CHEMBL100894 11094 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 432 5 1 5 2.9 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(O)(c2ccccc2)C(F)(F)F)CC1 10.1021/jm00072a019
10003108 114274 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 435 7 1 6 3.0 CCOC(=O)NC(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccccc1 10.1021/jm00072a019
CHEMBL318563 114274 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 435 7 1 6 3.0 CCOC(=O)NC(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccccc1 10.1021/jm00072a019
44350001 18238 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL1180380 18238 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL124534 18238 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL127678 18238 0 None - 1 Guinea pig 7.9 pIC50 = 7.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
3075909 209536 7 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 617 13 1 10 3.5 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)NCCC(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL6202 209536 7 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 617 13 1 10 3.5 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)NCCC(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
14785986 18251 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 591 24 0 6 7.5 CCCCCCCCCCCCCCCCCCOCC1OCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL1180401 18251 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 591 24 0 6 7.5 CCCCCCCCCCCCCCCCCCOCC1OCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL125412 18251 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 591 24 0 6 7.5 CCCCCCCCCCCCCCCCCCOCC1OCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
14785967 18283 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 503 18 0 4 7.0 CCCCCCCCCCCCCCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL1180472 18283 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 503 18 0 4 7.0 CCCCCCCCCCCCCCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL127324 18283 0 None - 1 Guinea pig 6.9 pIC50 = 6.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 503 18 0 4 7.0 CCCCCCCCCCCCCCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
524022 38418 1 None - 1 Human 5.9 pIC50 = 5.9 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 318 0 0 2 3.6 CC(=O)N1CCC(=C2c3ccccc3CCc3cccnc32)CC1 10.1021/jm00105a069
CHEMBL140483 38418 1 None - 1 Human 5.9 pIC50 = 5.9 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 318 0 0 2 3.6 CC(=O)N1CCC(=C2c3ccccc3CCc3cccnc32)CC1 10.1021/jm00105a069
15005360 12182 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 606 7 3 9 5.7 CCOC(=O)C1=C(c2ccc(-n3c(O)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL107198 12182 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 606 7 3 9 5.7 CCOC(=O)C1=C(c2ccc(-n3c(O)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
14992513 179441 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 631 21 0 7 9.0 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3c(C)sc(C)c3C)c2)c1OC 10.1021/jm00087a023
CHEMBL44978 179441 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 631 21 0 7 9.0 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3c(C)sc(C)c3C)c2)c1OC 10.1021/jm00087a023
14785910 18271 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 510 25 0 4 8.6 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL1180448 18271 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 510 25 0 4 8.6 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL126524 18271 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 510 25 0 4 8.6 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
14785898 18292 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 496 24 0 4 7.7 CCCCCCCCCCCCCCOCC1COC(COCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL1180486 18292 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 496 24 0 4 7.7 CCCCCCCCCCCCCCOCC1COC(COCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL127766 18292 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 496 24 0 4 7.7 CCCCCCCCCCCCCCOCC1COC(COCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
14785870 18951 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 524 26 0 4 8.5 CCCCCCCCCCCCCCCCOCC1CC(COCCCCCC[n+]2ccsc2)CO1 10.1021/jm00105a058
CHEMBL1184227 18951 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 524 26 0 4 8.5 CCCCCCCCCCCCCCCCOCC1CC(COCCCCCC[n+]2ccsc2)CO1 10.1021/jm00105a058
CHEMBL340164 18951 0 None - 1 Guinea pig 5.9 pIC50 = 5.9 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 524 26 0 4 8.5 CCCCCCCCCCCCCCCCOCC1CC(COCCCCCC[n+]2ccsc2)CO1 10.1021/jm00105a058
44372248 18445 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 530 25 2 5 6.4 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)NCC[N+](C)(C)C)OC 10.1021/jm00121a012
CHEMBL1181143 18445 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 530 25 2 5 6.4 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)NCC[N+](C)(C)C)OC 10.1021/jm00121a012
CHEMBL156926 18445 0 None - 1 Guinea pig 4.9 pIC50 = 4.9 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 530 25 2 5 6.4 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)NCC[N+](C)(C)C)OC 10.1021/jm00121a012
14992525 185427 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 586 21 0 7 7.4 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccn(C)c3)c2)c1OC 10.1021/jm00087a023
CHEMBL46762 185427 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 586 21 0 7 7.4 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccn(C)c3)c2)c1OC 10.1021/jm00087a023
21463470 17895 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 587 26 1 4 9.2 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCC[n+]2ccccc2)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178059 17895 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 587 26 1 4 9.2 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCC[n+]2ccccc2)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL12337 17895 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 587 26 1 4 9.2 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCC[n+]2ccccc2)CCCC1 10.1016/0960-894X(95)00173-Q
1859 7223 62 None -1 2 Guinea pig 6.8 pIC50 = 6.8 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00095a005
1860 7223 62 None -1 2 Guinea pig 6.8 pIC50 = 6.8 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00095a005
65889 7223 62 None -1 2 Guinea pig 6.8 pIC50 = 6.8 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00095a005
CHEMBL280164 7223 62 None -1 2 Guinea pig 6.8 pIC50 = 6.8 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00095a005
44267846 17884 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 518 25 0 4 7.6 CCCCCCCCCCCCCCCCOCC1(COC(=O)CCCCC[n+]2ccccc2)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL11754 17884 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 518 25 0 4 7.6 CCCCCCCCCCCCCCCCOCC1(COC(=O)CCCCC[n+]2ccccc2)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178036 17884 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 518 25 0 4 7.6 CCCCCCCCCCCCCCCCOCC1(COC(=O)CCCCC[n+]2ccccc2)COC1 10.1016/0960-894X(95)00173-Q
44290615 108065 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 622 21 0 7 8.2 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[N+]3=CN=C4C=CC=CC43)c2)c1OC 10.1021/jm00087a023
CHEMBL296432 108065 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 622 21 0 7 8.2 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[N+]3=CN=C4C=CC=CC43)c2)c1OC 10.1021/jm00087a023
14992371 173105 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 541 14 0 8 4.6 COC(COc1ccc(OCc2ccccc2)cc1)COP(=O)([O-])Oc1cccc(C[n+]2ccsc2)c1 10.1021/jm00087a023
CHEMBL42725 173105 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 541 14 0 8 4.6 COC(COc1ccc(OCc2ccccc2)cc1)COP(=O)([O-])Oc1cccc(C[n+]2ccsc2)c1 10.1021/jm00087a023
10428978 17251 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 366 2 1 5 4.8 Cc1nc2cnccc2n1-c1ccc(C2=CCC(=O)c3ccccc3N2)cc1 10.1021/jm00018a011
CHEMBL116515 17251 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 366 2 1 5 4.8 Cc1nc2cnccc2n1-c1ccc(C2=CCC(=O)c3ccccc3N2)cc1 10.1021/jm00018a011
10476688 122564 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 410 6 1 4 4.6 N#CC1(Nc2cccnc2)CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL335432 122564 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 410 6 1 4 4.6 N#CC1(Nc2cccnc2)CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
15123192 18489 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 569 19 0 6 5.8 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCCCCCOCCCCCc2ccccc2)C1 10.1021/jm00082a007
CHEMBL1181266 18489 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 569 19 0 6 5.8 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCCCCCOCCCCCc2ccccc2)C1 10.1021/jm00082a007
CHEMBL160995 18489 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 569 19 0 6 5.8 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCCCCCOCCCCCc2ccccc2)C1 10.1021/jm00082a007
15123194 18494 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 589 16 0 6 6.3 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCCCCCOCc2ccc(-c3ccccc3)cc2)C1 10.1021/jm00082a007
CHEMBL1181278 18494 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 589 16 0 6 6.3 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCCCCCOCc2ccc(-c3ccccc3)cc2)C1 10.1021/jm00082a007
CHEMBL161597 18494 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 589 16 0 6 6.3 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCCCCCOCc2ccc(-c3ccccc3)cc2)C1 10.1021/jm00082a007
15005334 116571 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 581 7 2 7 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc(C)c3C)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL323290 116571 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 581 7 2 7 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc(C)c3C)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
44350422 18276 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 620 24 1 8 6.5 CCCCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL1180461 18276 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 620 24 1 8 6.5 CCCCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL126958 18276 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 620 24 1 8 6.5 CCCCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
14785996 18282 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 563 22 0 6 6.7 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL1180471 18282 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 563 22 0 6 6.7 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL127266 18282 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 563 22 0 6 6.7 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL338441 18282 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 563 22 0 6 6.7 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL319839 115164 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 501 9 1 8 5.0 CCO/C(O)=C1\C(COCCn2c(C)nc(C)c2C)=NC(C)=C(C(=O)OC)[C@H]1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
10390185 114261 0 None - 1 Guinea pig 6.8 pIC50 = 6.8 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 475 7 1 5 3.8 Cc1ncccc1C(C#N)N1CCN(C(=O)CNC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm00072a019
CHEMBL318460 114261 0 None - 1 Guinea pig 6.8 pIC50 = 6.8 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 475 7 1 5 3.8 Cc1ncccc1C(C#N)N1CCN(C(=O)CNC(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm00072a019
6917920 108226 2 None -69 2 Human 5.8 pIC50 = 5.8 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 404 8 0 7 4.3 COc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OC 10.1021/jm00105a069
CHEMBL297624 108226 2 None -69 2 Human 5.8 pIC50 = 5.8 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 404 8 0 7 4.3 COc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OC 10.1021/jm00105a069
44372250 18460 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 572 25 1 6 6.7 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+](C)(C)C)C(C)=O)OC 10.1021/jm00121a012
CHEMBL1181188 18460 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 572 25 1 6 6.7 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+](C)(C)C)C(C)=O)OC 10.1021/jm00121a012
CHEMBL158489 18460 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 572 25 1 6 6.7 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+](C)(C)C)C(C)=O)OC 10.1021/jm00121a012
14785868 18290 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 566 27 0 5 8.8 CCCCCCCCCCCCCCCCCCOCC1CC(COC(=O)CCCCC[n+]2ccsc2)CO1 10.1021/jm00105a058
CHEMBL1180483 18290 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 566 27 0 5 8.8 CCCCCCCCCCCCCCCCCCOCC1CC(COC(=O)CCCCC[n+]2ccsc2)CO1 10.1021/jm00105a058
CHEMBL127704 18290 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 566 27 0 5 8.8 CCCCCCCCCCCCCCCCCCOCC1CC(COC(=O)CCCCC[n+]2ccsc2)CO1 10.1021/jm00105a058
10461336 84220 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.
ChEMBL 607 32 0 6 8.7 CCCCCCC(CCCCCC)CCCCCCCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)OC 10.1021/jm00007a018
CHEMBL20869 84220 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.
ChEMBL 607 32 0 6 8.7 CCCCCCC(CCCCCC)CCCCCCCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)OC 10.1021/jm00007a018
10031400 18418 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 467 19 1 2 6.5 CCCCCCCCCCCCCCOc1ccc(CC(=O)NCCc2cccc[n+]2C)cc1 10.1021/jm00057a008
CHEMBL1181049 18418 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 467 19 1 2 6.5 CCCCCCCCCCCCCCOc1ccc(CC(=O)NCCc2cccc[n+]2C)cc1 10.1021/jm00057a008
CHEMBL153901 18418 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 467 19 1 2 6.5 CCCCCCCCCCCCCCOc1ccc(CC(=O)NCCc2cccc[n+]2C)cc1 10.1021/jm00057a008
14992475 175730 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 615 21 0 7 8.6 CCCCCCCCCCCCCCOc1ccc(C(C)=O)c(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1 10.1021/jm00087a023
CHEMBL43887 175730 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 615 21 0 7 8.6 CCCCCCCCCCCCCCOc1ccc(C(C)=O)c(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1 10.1021/jm00087a023
9978623 11487 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 405 6 1 5 2.0 CNC(=O)C(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccccc1 10.1021/jm00072a019
CHEMBL103546 11487 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 405 6 1 5 2.0 CNC(=O)C(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccccc1 10.1021/jm00072a019
10367510 11241 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 471 8 0 5 4.4 CCOC(=O)C(c1cccnc1C)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL101794 11241 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 471 8 0 5 4.4 CCOC(=O)C(c1cccnc1C)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
14992365 108096 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 633 23 0 8 7.7 CCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)OC)c1 10.1021/jm00087a023
CHEMBL29665 108096 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 633 23 0 8 7.7 CCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)OC)c1 10.1021/jm00087a023
14992398 16989 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 602 25 2 6 8.0 CCCCCCCCCCCCCCCCOCC(COP(=O)(O)Oc1cccc(CN(C)/C(S)=N\C)c1)OC 10.1021/jm00087a023
CHEMBL1160088 16989 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 602 25 2 6 8.0 CCCCCCCCCCCCCCCCOCC(COP(=O)(O)Oc1cccc(CN(C)/C(S)=N\C)c1)OC 10.1021/jm00087a023
21463443 17886 0 None - 1 Guinea pig 6.8 pIC50 = 6.8 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 618 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178039 17886 0 None - 1 Guinea pig 6.8 pIC50 = 6.8 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 618 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL11872 17886 0 None - 1 Guinea pig 6.8 pIC50 = 6.8 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 618 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL12352 17886 0 None - 1 Guinea pig 6.8 pIC50 = 6.8 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 618 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
44374445 18454 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 575 23 0 5 8.1 CCCCCCCCCCCCCCCCCCOC1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL1181172 18454 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 575 23 0 5 8.1 CCCCCCCCCCCCCCCCCCOC1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL157989 18454 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 575 23 0 5 8.1 CCCCCCCCCCCCCCCCCCOC1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
10005520 170264 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 483 7 1 6 4.0 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)Oc2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL420092 170264 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 483 7 1 6 4.0 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)Oc2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
10394508 18427 0 None - 1 Guinea pig 6.8 pIC50 = 6.8 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 525 19 0 4 7.3 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2CC)C(C)=O)cc1OC 10.1021/jm00057a008
CHEMBL1181068 18427 0 None - 1 Guinea pig 6.8 pIC50 = 6.8 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 525 19 0 4 7.3 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2CC)C(C)=O)cc1OC 10.1021/jm00057a008
CHEMBL154536 18427 0 None - 1 Guinea pig 6.8 pIC50 = 6.8 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 525 19 0 4 7.3 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2CC)C(C)=O)cc1OC 10.1021/jm00057a008
14786013 18940 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 589 24 0 5 8.2 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cc[n+](CC)cc2)C(C)=O)C1 10.1021/jm00105a058
CHEMBL1184202 18940 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 589 24 0 5 8.2 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cc[n+](CC)cc2)C(C)=O)C1 10.1021/jm00105a058
CHEMBL338828 18940 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 589 24 0 5 8.2 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cc[n+](CC)cc2)C(C)=O)C1 10.1021/jm00105a058
10099557 18083 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 444 13 0 5 5.2 CCCCCCOc1c(OC)cc(C(=O)OCc2ccccc2C[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL1179276 18083 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 444 13 0 5 5.2 CCCCCCOc1c(OC)cc(C(=O)OCc2ccccc2C[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL67396 18083 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 444 13 0 5 5.2 CCCCCCOc1c(OC)cc(C(=O)OCc2ccccc2C[N+](C)(C)C)cc1OC 10.1021/jm00012a012
14992411 175962 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 587 22 0 6 8.9 CCCCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)cc1 10.1021/jm00087a023
CHEMBL44060 175962 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 587 22 0 6 8.9 CCCCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)cc1 10.1021/jm00087a023
14992349 70269 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 619 23 0 8 7.3 CCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)OC)c1 10.1021/jm00087a023
CHEMBL17997 70269 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 619 23 0 8 7.3 CCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)OC)c1 10.1021/jm00087a023
14992417 185763 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 543 19 0 5 8.3 CCCCCCCCCCCCCCc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1 10.1021/jm00087a023
CHEMBL47073 185763 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 543 19 0 5 8.3 CCCCCCCCCCCCCCc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1 10.1021/jm00087a023
10340883 19601 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 399 2 0 7 3.3 Cc1nn(C)c2c1N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)CC(=O)N2C 10.1021/jm00018a012
CHEMBL118840 19601 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 399 2 0 7 3.3 Cc1nn(C)c2c1N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)CC(=O)N2C 10.1021/jm00018a012
9889462 11055 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 440 6 1 5 3.4 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(O)(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL100641 11055 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 440 6 1 5 3.4 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(O)(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL440149 175897 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 562 10 2 7 6.4 CCO/C(O)=C1\C(COCCn2c(C)nc(C)c2C)=NC(C)=C(C(=O)Nc2ccccc2)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
14960365 114282 0 None - 1 Guinea pig 6.8 pIC50 = 6.8 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 467 6 0 6 2.3 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)N2CCCS2(=O)=O)CC1 10.1021/jm00072a019
CHEMBL318590 114282 0 None - 1 Guinea pig 6.8 pIC50 = 6.8 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 467 6 0 6 2.3 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)N2CCCS2(=O)=O)CC1 10.1021/jm00072a019
14992327 179453 0 None - 1 Guinea pig 6.8 pIC50 = 6.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 668 27 1 8 8.3 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)([O-])Oc1cccc(C[n+]2csc(C)c2)c1)OC 10.1021/jm00087a023
CHEMBL44997 179453 0 None - 1 Guinea pig 6.8 pIC50 = 6.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 668 27 1 8 8.3 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)([O-])Oc1cccc(C[n+]2csc(C)c2)c1)OC 10.1021/jm00087a023
3075908 120904 4 None - 1 Guinea pig 6.8 pIC50 = 6.8 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 631 11 1 10 3.9 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)NC(C)C(C)(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL332848 120904 4 None - 1 Guinea pig 6.8 pIC50 = 6.8 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 631 11 1 10 3.9 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)NC(C)C(C)(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
3075899 209540 4 None - 1 Guinea pig 6.8 pIC50 = 6.8 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 642 11 0 10 4.2 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)c3ccccc3Cl)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL6203 209540 4 None - 1 Guinea pig 6.8 pIC50 = 6.8 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 642 11 0 10 4.2 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)c3ccccc3Cl)C2)cc(OC)c1OC 10.1021/jm00060a006
14785887 18237 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 508 25 0 3 9.3 CCCCCCCCCCCCCCCCC1COC(COCCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL1180379 18237 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 508 25 0 3 9.3 CCCCCCCCCCCCCCCCC1COC(COCCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL124523 18237 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 508 25 0 3 9.3 CCCCCCCCCCCCCCCCC1COC(COCCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
14785900 18241 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 510 25 0 4 8.1 CCCCCCCCCCCCCCOCC1COC(COCCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL1180384 18241 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 510 25 0 4 8.1 CCCCCCCCCCCCCCOCC1COC(COCCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL124581 18241 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 510 25 0 4 8.1 CCCCCCCCCCCCCCOCC1COC(COCCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
1116500 20643 9 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 371 6 0 6 2.1 COc1cc(C(=O)N2CCN(Cc3cccnc3)CC2)cc(OC)c1OC 10.1021/jm00100a018
CHEMBL1196032 20643 9 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 371 6 0 6 2.1 COc1cc(C(=O)N2CCN(Cc3cccnc3)CC2)cc(OC)c1OC 10.1021/jm00100a018
CHEMBL3215547 20643 9 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 371 6 0 6 2.1 COc1cc(C(=O)N2CCN(Cc3cccnc3)CC2)cc(OC)c1OC 10.1021/jm00100a018
10077214 19186 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 467 18 0 2 7.1 CCCCCCCCCCCCCCOc1cccc(CN(Cc2cccc[n+]2C)C(C)=O)c1 10.1021/jm00057a008
CHEMBL1185820 19186 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 467 18 0 2 7.1 CCCCCCCCCCCCCCOc1cccc(CN(Cc2cccc[n+]2C)C(C)=O)c1 10.1021/jm00057a008
CHEMBL434460 19186 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 467 18 0 2 7.1 CCCCCCCCCCCCCCOc1cccc(CN(Cc2cccc[n+]2C)C(C)=O)c1 10.1021/jm00057a008
14992433 108204 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 561 19 0 7 7.3 CCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1OC 10.1021/jm00087a023
CHEMBL297458 108204 0 None - 1 Guinea pig 4.8 pIC50 = 4.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 561 19 0 7 7.3 CCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1OC 10.1021/jm00087a023
120984 209617 23 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 474 8 0 8 2.3 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL6244 209617 23 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 474 8 0 8 2.3 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC 10.1021/jm00060a006
14992303 107868 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 689 27 0 8 9.2 CCCCCCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)OC)c1C 10.1021/jm00087a023
CHEMBL294983 107868 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 689 27 0 8 9.2 CCCCCCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)OC)c1C 10.1021/jm00087a023
14992419 173597 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 601 22 0 6 9.2 CCCCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1C 10.1021/jm00087a023
CHEMBL42848 173597 0 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 601 22 0 6 9.2 CCCCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1C 10.1021/jm00087a023
14960366 11444 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 503 8 1 6 3.2 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NS(=O)(=O)c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL103231 11444 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 503 8 1 6 3.2 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NS(=O)(=O)c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
9979382 11449 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 417 6 0 5 3.3 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)N2CCCC2)CC1 10.1021/jm00072a019
CHEMBL103287 11449 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 417 6 0 5 3.3 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)N2CCCC2)CC1 10.1021/jm00072a019
10048004 11056 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 424 6 0 4 4.3 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL100642 11056 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 424 6 0 4 4.3 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
10069753 11550 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 403 8 1 5 3.0 C=CCNC(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccccc1 10.1021/jm00072a019
CHEMBL103995 11550 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 403 8 1 5 3.0 C=CCNC(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccccc1 10.1021/jm00072a019
14785973 18264 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL1180435 18264 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL126302 18264 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL126981 18264 0 None - 1 Guinea pig 7.8 pIC50 = 7.8 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
14554145 37663 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 386 0 0 2 4.9 CC(=O)N1CCC(=C2c3cc(Cl)c(Cl)cc3CCc3cccnc32)CC1 10.1021/jm00105a069
CHEMBL139760 37663 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 386 0 0 2 4.9 CC(=O)N1CCC(=C2c3cc(Cl)c(Cl)cc3CCc3cccnc32)CC1 10.1021/jm00105a069
1392 106541 37 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.
ChEMBL 523 27 0 6 6.5 CCCCCCCCCCCCCCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)OC 10.1021/jm00007a018
CHEMBL28509 106541 37 None - 1 Guinea pig 5.8 pIC50 = 5.8 Functional
PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.
ChEMBL 523 27 0 6 6.5 CCCCCCCCCCCCCCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)OC 10.1021/jm00007a018
14992401 190693 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 587 22 0 6 8.9 CCCCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1 10.1021/jm00087a023
CHEMBL48129 190693 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 587 22 0 6 8.9 CCCCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1 10.1021/jm00087a023
CHEMBL105029 11777 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 501 9 1 8 5.0 CCO/C(O)=C1\C(COCCn2c(C)nc(C)c2C)=NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
44290665 189098 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 633 21 1 6 10.5 CCCCCCCCCCCCCCOc1cccc(OP(=O)(O)Oc2cccc(Cc3nccc4ccccc34)c2)c1OC 10.1021/jm00087a023
44290666 189098 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 633 21 1 6 10.5 CCCCCCCCCCCCCCOc1cccc(OP(=O)(O)Oc2cccc(Cc3nccc4ccccc34)c2)c1OC 10.1021/jm00087a023
CHEMBL47843 189098 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 633 21 1 6 10.5 CCCCCCCCCCCCCCOc1cccc(OP(=O)(O)Oc2cccc(Cc3nccc4ccccc34)c2)c1OC 10.1021/jm00087a023
14992443 107170 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 603 21 0 7 8.4 CCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)cc1OC 10.1021/jm00087a023
CHEMBL290038 107170 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 603 21 0 7 8.4 CCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)cc1OC 10.1021/jm00087a023
10485263 17889 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 631 22 1 6 6.5 CCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CN(C(C)=O)C1 10.1016/0960-894X(95)00173-Q
CHEMBL1178045 17889 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 631 22 1 6 6.5 CCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CN(C(C)=O)C1 10.1016/0960-894X(95)00173-Q
CHEMBL11989 17889 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 631 22 1 6 6.5 CCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CN(C(C)=O)C1 10.1016/0960-894X(95)00173-Q
14785996 18282 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 563 22 0 6 6.7 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL1180471 18282 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 563 22 0 6 6.7 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL127266 18282 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 563 22 0 6 6.7 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL338441 18282 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 563 22 0 6 6.7 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
9999041 104870 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 367 3 0 5 3.9 Cc1nc2cnccc2n1-c1ccc(C2=NN(c3ccccc3)C(=O)C2)cc1 10.1021/jm00018a011
CHEMBL273392 104870 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 367 3 0 5 3.9 Cc1nc2cnccc2n1-c1ccc(C2=NN(c3ccccc3)C(=O)C2)cc1 10.1021/jm00018a011
15123180 18465 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 441 10 0 5 3.5 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCCc2ccccc2)C1 10.1021/jm00082a007
CHEMBL1181205 18465 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 441 10 0 5 3.5 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCCc2ccccc2)C1 10.1021/jm00082a007
CHEMBL158908 18465 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 441 10 0 5 3.5 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCCc2ccccc2)C1 10.1021/jm00082a007
15005359 18857 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 646 10 2 8 7.4 CCCCc1nc2cnccc2n1-c1ccc(C2=C(C(=O)OCC)C(c3ccccc3Cl)C(C(=O)Nc3ccccn3)=C(C)N2)cc1 10.1021/jm00095a005
CHEMBL1183832 18857 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 646 10 2 8 7.4 CCCCc1nc2cnccc2n1-c1ccc(C2=C(C(=O)OCC)C(c3ccccc3Cl)C(C(=O)Nc3ccccn3)=C(C)N2)cc1 10.1021/jm00095a005
CHEMBL320226 18857 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 646 10 2 8 7.4 CCCCc1nc2cnccc2n1-c1ccc(C2=C(C(=O)OCC)C(c3ccccc3Cl)C(C(=O)Nc3ccccn3)=C(C)N2)cc1 10.1021/jm00095a005
10318577 20382 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 396 6 0 7 2.1 COc1cc(C(=O)N2CCN(C(C#N)c3cccnc3)CC2)cc(OC)c1OC 10.1021/jm00100a018
CHEMBL1194238 20382 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 396 6 0 7 2.1 COc1cc(C(=O)N2CCN(C(C#N)c3cccnc3)CC2)cc(OC)c1OC 10.1021/jm00100a018
CHEMBL3215728 20382 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 396 6 0 7 2.1 COc1cc(C(=O)N2CCN(C(C#N)c3cccnc3)CC2)cc(OC)c1OC 10.1021/jm00100a018
10408640 20450 2 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 399 5 0 3 3.6 O=C(CC(c1ccccc1)c1ccccc1)N1CCN(C(=O)c2ccncc2)CC1 10.1021/jm00100a018
CHEMBL1194725 20450 2 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 399 5 0 3 3.6 O=C(CC(c1ccccc1)c1ccccc1)N1CCN(C(=O)c2ccncc2)CC1 10.1021/jm00100a018
CHEMBL553152 20450 2 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 399 5 0 3 3.6 O=C(CC(c1ccccc1)c1ccccc1)N1CCN(C(=O)c2ccncc2)CC1 10.1021/jm00100a018
10070451 29950 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 415 5 0 3 2.8 O=C(CC(c1ccccc1)c1ccccc1)N1CCN(C(=O)c2cc[n+]([O-])cc2)CC1 10.1021/jm00100a018
CHEMBL133120 29950 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 415 5 0 3 2.8 O=C(CC(c1ccccc1)c1ccccc1)N1CCN(C(=O)c2cc[n+]([O-])cc2)CC1 10.1021/jm00100a018
14786021 18243 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 533 23 1 4 8.2 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)Nc2cc[n+](CC)cc2)C1 10.1021/jm00105a058
CHEMBL1180386 18243 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 533 23 1 4 8.2 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)Nc2cc[n+](CC)cc2)C1 10.1021/jm00105a058
CHEMBL124799 18243 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 533 23 1 4 8.2 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)Nc2cc[n+](CC)cc2)C1 10.1021/jm00105a058
14786027 18965 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 510 22 0 2 9.2 CCCCCCCCCCCCCCC1COC(COCCCCCC[n+]2cccc3ccccc32)C1 10.1021/jm00105a058
CHEMBL1184255 18965 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 510 22 0 2 9.2 CCCCCCCCCCCCCCC1COC(COCCCCCC[n+]2cccc3ccccc32)C1 10.1021/jm00105a058
CHEMBL341265 18965 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 510 22 0 2 9.2 CCCCCCCCCCCCCCC1COC(COCCCCCC[n+]2cccc3ccccc32)C1 10.1021/jm00105a058
14992423 107892 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 615 20 0 6 9.3 CCCCCCCCCCCCCCOc1c(C)cc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(C)c1C 10.1021/jm00087a023
CHEMBL295148 107892 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 615 20 0 6 9.3 CCCCCCCCCCCCCCOc1c(C)cc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(C)c1C 10.1021/jm00087a023
14992509 103425 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 617 21 0 7 8.7 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3c(C)csc3C)c2)c1OC 10.1021/jm00087a023
CHEMBL263675 103425 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 617 21 0 7 8.7 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3c(C)csc3C)c2)c1OC 10.1021/jm00087a023
14992519 188430 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 633 21 0 6 9.2 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3cccc4ccccc43)c2)c1OC 10.1021/jm00087a023
CHEMBL47760 188430 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 633 21 0 6 9.2 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3cccc4ccccc43)c2)c1OC 10.1021/jm00087a023
129796 107232 39 None -1 2 Human 8.7 pIC50 = 8.7 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
CHEMBL29067 107232 39 None -1 2 Human 8.7 pIC50 = 8.7 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
15123184 18467 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 577 23 0 6 7.0 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCCCCCCCCCCCCCCCOC)C1 10.1021/jm00082a007
CHEMBL1181208 18467 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 577 23 0 6 7.0 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCCCCCCCCCCCCCCCOC)C1 10.1021/jm00082a007
CHEMBL158974 18467 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 577 23 0 6 7.0 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCCCCCCCCCCCCCCCOC)C1 10.1021/jm00082a007
15005344 103338 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 603 7 2 7 6.9 CCOC(=O)C1=C(c2ccc(-c3c(C)nc4ccccn34)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL263022 103338 0 None - 1 Guinea pig 8.7 pIC50 = 8.7 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 603 7 2 7 6.9 CCOC(=O)C1=C(c2ccc(-c3c(C)nc4ccccn34)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
44344945 19571 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 419 2 0 7 4.6 Cc1cc2c(cc1C)-n1cnnc1CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a012
CHEMBL118813 19571 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 419 2 0 7 4.6 Cc1cc2c(cc1C)-n1cnnc1CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a012
15005372 116633 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 654 8 2 9 6.6 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1OC(F)(F)F 10.1021/jm00095a005
CHEMBL323382 116633 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 654 8 2 9 6.6 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1OC(F)(F)F 10.1021/jm00095a005
CHEMBL104967 11761 0 None - 1 Human 8.6 pIC50 = 8.6 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 564 9 2 7 6.2 CCO/C(O)=C1\C(COCCn2c(C)nc3ccccc32)=NC(C)=C(C(=O)NC(C)(C)C)[C@H]1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
9955997 17308 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 462 3 0 8 4.0 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(-c4cccnc4)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL116938 17308 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 462 3 0 8 4.0 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(-c4cccnc4)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
44344946 20386 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 433 2 0 7 4.9 Cc1cc2c(cc1C)-n1c(C)nnc1CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a012
CHEMBL119425 20386 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 433 2 0 7 4.9 Cc1cc2c(cc1C)-n1c(C)nnc1CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a012
10435878 20857 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 495 3 0 8 3.1 Cc1nc2cnccc2n1-c1ccc(C2=Nc3cc(C(=O)N4CCOCC4)cnc3N(C)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL119763 20857 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 495 3 0 8 3.1 Cc1nc2cnccc2n1-c1ccc(C2=Nc3cc(C(=O)N4CCOCC4)cnc3N(C)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL106819 12105 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 618 8 1 8 7.9 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)N=C(C)/C(=C(/O)OCc2ccccc2)C1c1ccccc1Cl 10.1021/jm00095a005
10455159 123797 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 426 6 1 5 3.1 N#CC(c1ccncc1)N1CCN(C(=O)CC(O)(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL338940 123797 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 426 6 1 5 3.1 N#CC(c1ccncc1)N1CCN(C(=O)CC(O)(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
10456275 21414 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 447 3 1 7 4.6 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(c(-c4ccccc4)nn3C)NC(=O)C2)cc1 10.1021/jm00018a012
CHEMBL120515 21414 0 None - 1 Guinea pig 8.6 pIC50 = 8.6 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 447 3 1 7 4.6 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(c(-c4ccccc4)nn3C)NC(=O)C2)cc1 10.1021/jm00018a012
10341520 11150 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 410 6 0 4 4.0 N#CC(c1cccnc1)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL101245 11150 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 410 6 0 4 4.0 N#CC(c1cccnc1)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
10071653 10997 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 435 6 0 6 2.9 COC(=O)N(C)C(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccccc1 10.1021/jm00072a019
CHEMBL100340 10997 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 435 6 0 6 2.9 COC(=O)N(C)C(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccccc1 10.1021/jm00072a019
9982678 11074 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 481 7 0 5 3.7 CC(=O)N(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)C(c1ccccc1)c1ccccc1 10.1021/jm00072a019
CHEMBL100809 11074 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 481 7 0 5 3.7 CC(=O)N(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)C(c1ccccc1)c1ccccc1 10.1021/jm00072a019
10341520 11150 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 410 6 0 4 4.0 N#CC(c1cccnc1)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL101245 11150 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 410 6 0 4 4.0 N#CC(c1cccnc1)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
10344531 114611 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 467 8 0 5 4.4 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)N(C)Cc2ccccc2)CC1 10.1021/jm00072a019
CHEMBL319229 114611 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 467 8 0 5 4.4 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)N(C)Cc2ccccc2)CC1 10.1021/jm00072a019
107757 8005 3 None -4 2 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1021/jm00057a008
1852 8005 3 None -4 2 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1021/jm00057a008
CHEMBL1180101 8005 3 None -4 2 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1021/jm00057a008
44344703 117598 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 373 2 2 5 3.1 Cc1nc2cnccc2n1-c1ccc(C2=CC(=O)NC3CCCCC3N2)cc1 10.1021/jm00018a011
CHEMBL326077 117598 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 373 2 2 5 3.1 Cc1nc2cnccc2n1-c1ccc(C2=CC(=O)NC3CCCCC3N2)cc1 10.1021/jm00018a011
10093925 122275 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 425 7 2 5 3.8 N#CC1(Nc2cccnc2)CCN(C(=O)CNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL335176 122275 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 425 7 2 5 3.8 N#CC1(Nc2cccnc2)CCN(C(=O)CNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
15005342 11857 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 554 7 2 7 6.3 CCOC(=O)C1=C(c2ccc(-c3ocnc3C)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL105500 11857 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 554 7 2 7 6.3 CCOC(=O)C1=C(c2ccc(-c3ocnc3C)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
14992429 108040 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 649 21 0 6 10.1 CCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(-c2ccccc2)c1 10.1021/jm00087a023
CHEMBL296238 108040 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 649 21 0 6 10.1 CCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(-c2ccccc2)c1 10.1021/jm00087a023
44371929 18450 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 592 24 1 6 7.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1cccc[n+]1C)C(C)=O)OC 10.1021/jm00121a012
CHEMBL1181154 18450 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 592 24 1 6 7.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1cccc[n+]1C)C(C)=O)OC 10.1021/jm00121a012
CHEMBL157246 18450 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 592 24 1 6 7.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1cccc[n+]1C)C(C)=O)OC 10.1021/jm00121a012
14786009 18297 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 547 21 0 5 6.9 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2C)C(C)=O)C1 10.1021/jm00105a058
CHEMBL1180492 18297 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 547 21 0 5 6.9 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2C)C(C)=O)C1 10.1021/jm00105a058
CHEMBL127890 18297 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 547 21 0 5 6.9 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2C)C(C)=O)C1 10.1021/jm00105a058
9985047 18073 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 424 16 0 5 5.1 CCCCCCCCCCOc1c(OC)cc(C(=O)OCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL1179248 18073 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 424 16 0 5 5.1 CCCCCCCCCCOc1c(OC)cc(C(=O)OCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL66344 18073 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 424 16 0 5 5.1 CCCCCCCCCCOc1c(OC)cc(C(=O)OCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
14992459 175875 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 607 20 0 6 9.1 CCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(Cl)c1 10.1021/jm00087a023
CHEMBL43993 175875 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 607 20 0 6 9.1 CCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(Cl)c1 10.1021/jm00087a023
10416972 18444 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 537 17 0 3 8.1 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2ccc[n+](C)c2)C(C)=O)cc1C(C)(C)C 10.1021/jm00057a008
CHEMBL1181140 18444 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 537 17 0 3 8.1 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2ccc[n+](C)c2)C(C)=O)cc1C(C)(C)C 10.1021/jm00057a008
CHEMBL156891 18444 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 537 17 0 3 8.1 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2ccc[n+](C)c2)C(C)=O)cc1C(C)(C)C 10.1021/jm00057a008
14785918 18288 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 468 20 0 5 6.6 CCCCCCCCCCCCCC1OCC(COC(=O)CCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL1180480 18288 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 468 20 0 5 6.6 CCCCCCCCCCCCCC1OCC(COC(=O)CCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL127464 18288 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 468 20 0 5 6.6 CCCCCCCCCCCCCC1OCC(COC(=O)CCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
10393263 84270 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.
ChEMBL 571 27 0 6 6.9 COC(COCCCCCCCCCCCCCCCCc1ccccc1)COP(=O)([O-])OCC[N+](C)(C)C 10.1021/jm00007a018
CHEMBL20873 84270 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.
ChEMBL 571 27 0 6 6.9 COC(COCCCCCCCCCCCCCCCCc1ccccc1)COP(=O)([O-])OCC[N+](C)(C)C 10.1021/jm00007a018
14992481 185412 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 677 22 0 7 9.6 CCCCCCCCCCCCCCOc1ccc(C(=O)c2ccccc2)c(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1 10.1021/jm00087a023
CHEMBL46752 185412 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 677 22 0 7 9.6 CCCCCCCCCCCCCCOc1ccc(C(=O)c2ccccc2)c(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1 10.1021/jm00087a023
10410208 11516 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 426 6 1 5 3.1 N#CC(c1cccnc1)N1CCN(C(=O)CC(O)(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL103753 11516 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 426 6 1 5 3.1 N#CC(c1cccnc1)N1CCN(C(=O)CC(O)(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
10382241 20160 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 334 4 0 4 2.6 CC(C(=O)N1CCN(C(C#N)c2cccnc2)CC1)c1ccccc1 10.1021/jm00100a018
CHEMBL1192625 20160 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 334 4 0 4 2.6 CC(C(=O)N1CCN(C(C#N)c2cccnc2)CC1)c1ccccc1 10.1021/jm00100a018
CHEMBL3216182 20160 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 334 4 0 4 2.6 CC(C(=O)N1CCN(C(C#N)c2cccnc2)CC1)c1ccccc1 10.1021/jm00100a018
10001979 123369 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 416 6 0 5 4.1 N#CC(c1cncs1)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL336612 123369 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 416 6 0 5 4.1 N#CC(c1cncs1)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
10408388 124854 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 395 5 0 3 4.8 N#CC(c1cccnc1)C1CCN(C(=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL340544 124854 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 395 5 0 3 4.8 N#CC(c1cccnc1)C1CCN(C(=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
11741454 117143 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 396 2 1 6 4.2 Cc1cc(C)c2c(n1)N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)CC(=O)N2 10.1021/jm00018a012
CHEMBL324154 117143 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 396 2 1 6 4.2 Cc1cc(C)c2c(n1)N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)CC(=O)N2 10.1021/jm00018a012
132115 18491 1 None -1 2 Guinea pig 7.7 pIC50 = 7.7 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 575 23 0 5 8.1 CCCCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL1181271 18491 1 None -1 2 Guinea pig 7.7 pIC50 = 7.7 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 575 23 0 5 8.1 CCCCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL161096 18491 1 None -1 2 Guinea pig 7.7 pIC50 = 7.7 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 575 23 0 5 8.1 CCCCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL290840 18491 1 None -1 2 Guinea pig 7.7 pIC50 = 7.7 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 575 23 0 5 8.1 CCCCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
10410208 11516 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 426 6 1 5 3.1 N#CC(c1cccnc1)N1CCN(C(=O)CC(O)(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL103753 11516 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 426 6 1 5 3.1 N#CC(c1cccnc1)N1CCN(C(=O)CC(O)(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
14960367 103587 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 441 7 1 6 1.8 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NS(C)(=O)=O)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL265057 103587 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 441 7 1 6 1.8 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NS(C)(=O)=O)c2ccccc2)CC1 10.1021/jm00072a019
44268105 17894 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 606 22 1 6 7.6 CCCCCCCCCCCCCCCCNC(=O)OC[C@@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
CHEMBL1178055 17894 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 606 22 1 6 7.6 CCCCCCCCCCCCCCCCNC(=O)OC[C@@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
CHEMBL12183 17894 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 606 22 1 6 7.6 CCCCCCCCCCCCCCCCNC(=O)OC[C@@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
13457165 201350 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 501 9 1 8 5.0 CCO/C(O)=C1\C(COCCn2c(C)nc(C)c2C)=NC(C)=C(C(=O)OC)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
CHEMBL53019 201350 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 501 9 1 8 5.0 CCO/C(O)=C1\C(COCCn2c(C)nc(C)c2C)=NC(C)=C(C(=O)OC)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
14785954 20939 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 545 21 0 4 8.1 CCCCCCCCCCCCCCCCCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL1198574 20939 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 545 21 0 4 8.1 CCCCCCCCCCCCCCCCCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL124071 20939 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 545 21 0 4 8.1 CCCCCCCCCCCCCCCCCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
14992421 107923 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 615 20 0 6 9.3 CCCCCCCCCCCCCCOc1cc(C)c(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(C)c1C 10.1021/jm00087a023
CHEMBL295379 107923 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 615 20 0 6 9.3 CCCCCCCCCCCCCCOc1cc(C)c(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(C)c1C 10.1021/jm00087a023
14785982 18939 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 547 21 0 5 7.5 CCCCCCCCCCCCCCCCCC1OCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL1184201 18939 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 547 21 0 5 7.5 CCCCCCCCCCCCCCCCCC1OCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL338689 18939 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 547 21 0 5 7.5 CCCCCCCCCCCCCCCCCC1OCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
14785954 20939 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 545 21 0 4 8.1 CCCCCCCCCCCCCCCCCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL1198574 20939 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 545 21 0 4 8.1 CCCCCCCCCCCCCCCCCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL124071 20939 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 545 21 0 4 8.1 CCCCCCCCCCCCCCCCCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
10053949 18070 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 452 18 0 5 5.9 CCCCCCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL1179244 18070 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 452 18 0 5 5.9 CCCCCCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL66185 18070 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 452 18 0 5 5.9 CCCCCCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
14785874 18239 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 466 22 0 3 8.1 CCCCCCCCCCCCCCC1COC(COCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL1180381 18239 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 466 22 0 3 8.1 CCCCCCCCCCCCCCC1COC(COCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL124535 18239 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 466 22 0 3 8.1 CCCCCCCCCCCCCCC1COC(COCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
14785866 18277 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 538 27 0 4 8.9 CCCCCCCCCCCCCCCCCCOCC1CC(COCCCCC[n+]2ccsc2)CO1 10.1021/jm00105a058
CHEMBL1180462 18277 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 538 27 0 4 8.9 CCCCCCCCCCCCCCCCCCOCC1CC(COCCCCC[n+]2ccsc2)CO1 10.1021/jm00105a058
CHEMBL127009 18277 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 538 27 0 4 8.9 CCCCCCCCCCCCCCCCCCOCC1CC(COCCCCC[n+]2ccsc2)CO1 10.1021/jm00105a058
44273696 84779 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.
ChEMBL 523 26 0 7 5.3 CCCCCC(=O)CCCCCCCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)OC 10.1021/jm00007a018
CHEMBL20974 84779 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.
ChEMBL 523 26 0 7 5.3 CCCCCC(=O)CCCCCCCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)OC 10.1021/jm00007a018
10026451 29377 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 443 6 0 3 5.3 N#CC(c1cccc(Cl)c1)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL132655 29377 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 443 6 0 3 5.3 N#CC(c1cccc(Cl)c1)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
14992501 108248 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 601 18 0 6 8.9 CCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)cc1C(C)(C)C 10.1021/jm00087a023
CHEMBL297765 108248 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 601 18 0 6 8.9 CCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)cc1C(C)(C)C 10.1021/jm00087a023
44290506 108007 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 659 26 0 7 9.1 CCCCCCCCCCCCCCCCc1ccccc1OCC(COP(=O)([O-])Oc1cccc(C[n+]2ccsc2)c1)OC 10.1021/jm00087a023
CHEMBL296047 108007 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 659 26 0 7 9.1 CCCCCCCCCCCCCCCCc1ccccc1OCC(COP(=O)([O-])Oc1cccc(C[n+]2ccsc2)c1)OC 10.1021/jm00087a023
14992431 185840 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 649 21 0 6 10.1 CCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)cc1-c1ccccc1 10.1021/jm00087a023
CHEMBL47149 185840 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 649 21 0 6 10.1 CCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)cc1-c1ccccc1 10.1021/jm00087a023
10101014 17882 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 547 22 0 5 7.0 CCCCCCCCCCCCCCCCOCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL11713 17882 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 547 22 0 5 7.0 CCCCCCCCCCCCCCCCOCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178031 17882 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 547 22 0 5 7.0 CCCCCCCCCCCCCCCCOCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
15005356 12201 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4ccncc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL107321 12201 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4ccncc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
10097385 174645 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 497 8 1 6 4.2 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)OCc2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL431049 174645 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 497 8 1 6 4.2 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)OCc2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
9939586 18423 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 537 17 0 3 8.1 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2C)C(C)=O)cc1C(C)(C)C 10.1021/jm00057a008
CHEMBL1181061 18423 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 537 17 0 3 8.1 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2C)C(C)=O)cc1C(C)(C)C 10.1021/jm00057a008
CHEMBL154282 18423 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 537 17 0 3 8.1 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2C)C(C)=O)cc1C(C)(C)C 10.1021/jm00057a008
44350001 18238 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL1180380 18238 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL124534 18238 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL127678 18238 0 None - 1 Guinea pig 7.7 pIC50 = 7.7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL105908 11933 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 542 9 2 7 5.7 CCO/C(O)=C1\C(COCCn2c(C)nc(C)c2C)=NC(C)=C(C(=O)NC(C)(C)C)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
10094738 20113 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 439 8 1 5 3.2 N#CC(c1cccnc1)N1CCN(C(=O)CNCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL1192218 20113 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 439 8 1 5 3.2 N#CC(c1cccnc1)N1CCN(C(=O)CNCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL543420 20113 0 None - 1 Guinea pig 6.7 pIC50 = 6.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 439 8 1 5 3.2 N#CC(c1cccnc1)N1CCN(C(=O)CNCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
10318313 20549 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 391 8 0 5 2.4 CN(CCCc1ccccc1)CC(=O)N1CCN(C(C#N)c2cccnc2)CC1 10.1021/jm00100a018
CHEMBL1195411 20549 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 391 8 0 5 2.4 CN(CCCc1ccccc1)CC(=O)N1CCN(C(C#N)c2cccnc2)CC1 10.1021/jm00100a018
CHEMBL3216385 20549 0 None - 1 Guinea pig 5.7 pIC50 = 5.7 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 391 8 0 5 2.4 CN(CCCc1ccccc1)CC(=O)N1CCN(C(C#N)c2cccnc2)CC1 10.1021/jm00100a018
14992491 185758 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 381 6 0 5 3.7 O=P([O-])(Oc1cccc(Cl)c1)Oc1cccc(C[n+]2ccsc2)c1 10.1021/jm00087a023
CHEMBL47069 185758 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 381 6 0 5 3.7 O=P([O-])(Oc1cccc(Cl)c1)Oc1cccc(C[n+]2ccsc2)c1 10.1021/jm00087a023
2118 210264 36 None -42 4 Guinea pig 4.7 pIC50 = 4.7 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 308 1 0 4 3.6 Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2 10.1021/jm00057a008
CHEMBL661 210264 36 None -42 4 Guinea pig 4.7 pIC50 = 4.7 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 308 1 0 4 3.6 Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2 10.1021/jm00057a008
10004583 18080 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 336 12 0 3 4.3 CCCCCCOc1ccc(C(=O)OCCCC[N+](C)(C)C)cc1 10.1021/jm00012a012
CHEMBL1179268 18080 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 336 12 0 3 4.3 CCCCCCOc1ccc(C(=O)OCCCC[N+](C)(C)C)cc1 10.1021/jm00012a012
CHEMBL67031 18080 0 None - 1 Guinea pig 4.7 pIC50 = 4.7 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 336 12 0 3 4.3 CCCCCCOc1ccc(C(=O)OCCCC[N+](C)(C)C)cc1 10.1021/jm00012a012
44267844 17881 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 605 27 1 5 8.8 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccccc2)CSC1 10.1016/0960-894X(95)00173-Q
CHEMBL11696 17881 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 605 27 1 5 8.8 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccccc2)CSC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178030 17881 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 605 27 1 5 8.8 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccccc2)CSC1 10.1016/0960-894X(95)00173-Q
10454370 123006 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 412 5 0 4 4.4 N#CC(c1cccnc1)N1CCN(C(=S)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL335853 123006 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 412 5 0 4 4.4 N#CC(c1cccnc1)N1CCN(C(=S)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
15005335 12177 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 553 7 2 7 5.8 CCOC(=O)C1=C(c2ccc(-n3ccnc3C)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL107159 12177 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 553 7 2 7 5.8 CCOC(=O)C1=C(c2ccc(-n3ccnc3C)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
10476687 122207 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 410 6 0 4 3.8 N#CC(c1cccnc1)N1CCN(C(=O)C(Cc2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL335044 122207 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 410 6 0 4 3.8 N#CC(c1cccnc1)N1CCN(C(=O)C(Cc2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
14992363 178141 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 661 24 0 8 8.3 CCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)OCC)c1C 10.1021/jm00087a023
CHEMBL44617 178141 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 661 24 0 8 8.3 CCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)OCC)c1C 10.1021/jm00087a023
10409305 29596 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 410 6 0 4 3.7 N#CC(CN1CCN(C(=O)C(c2ccccc2)c2ccccc2)CC1)c1cccnc1 10.1021/jm00100a018
CHEMBL132824 29596 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 410 6 0 4 3.7 N#CC(CN1CCN(C(=O)C(c2ccccc2)c2ccccc2)CC1)c1cccnc1 10.1021/jm00100a018
44372260 18481 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 588 25 1 7 6.9 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+](C)(C)C)C(=O)OC)OC 10.1021/jm00121a012
CHEMBL1181249 18481 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 588 25 1 7 6.9 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+](C)(C)C)C(=O)OC)OC 10.1021/jm00121a012
CHEMBL160653 18481 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 588 25 1 7 6.9 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+](C)(C)C)C(=O)OC)OC 10.1021/jm00121a012
14786025 18236 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 547 21 0 5 7.4 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(C(C)=O)c2ccc[n+](CC)c2)C1 10.1021/jm00105a058
CHEMBL1180378 18236 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 547 21 0 5 7.4 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(C(C)=O)c2ccc[n+](CC)c2)C1 10.1021/jm00105a058
CHEMBL124521 18236 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 547 21 0 5 7.4 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(C(C)=O)c2ccc[n+](CC)c2)C1 10.1021/jm00105a058
1147874 19917 14 None - 1 Guinea pig 4.6 pIC50 = 4.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 385 4 0 3 3.2 O=C(c1cccnc1)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL1190655 19917 14 None - 1 Guinea pig 4.6 pIC50 = 4.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 385 4 0 3 3.2 O=C(c1cccnc1)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL541329 19917 14 None - 1 Guinea pig 4.6 pIC50 = 4.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 385 4 0 3 3.2 O=C(c1cccnc1)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
14992389 108082 0 None - 1 Guinea pig 4.6 pIC50 = 4.6 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 627 25 0 6 8.6 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2ccc3ccccc3c2)c1)OC 10.1021/jm00087a023
CHEMBL296539 108082 0 None - 1 Guinea pig 4.6 pIC50 = 4.6 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 627 25 0 6 8.6 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2ccc3ccccc3c2)c1)OC 10.1021/jm00087a023
10002537 29627 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 425 7 0 5 3.5 N#CC(c1cccnc1)N1CCN(C(=O)CN(Cc2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL132852 29627 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 425 7 0 5 3.5 N#CC(c1cccnc1)N1CCN(C(=O)CN(Cc2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
10025386 31159 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 424 7 1 4 4.3 N#CC(c1cccnc1)C1CCN(C(=O)CNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL134123 31159 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 424 7 1 4 4.3 N#CC(c1cccnc1)C1CCN(C(=O)CNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
44350316 18226 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 547 21 0 5 7.5 CCCCCCCCCCCCCCCCCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL1180357 18226 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 547 21 0 5 7.5 CCCCCCCCCCCCCCCCCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL123570 18226 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 547 21 0 5 7.5 CCCCCCCCCCCCCCCCCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
10043426 20217 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 349 6 1 5 1.6 N#CC(c1cccnc1)N1CCN(C(=O)CNCc2ccccc2)CC1 10.1021/jm00100a018
CHEMBL1193029 20217 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 349 6 1 5 1.6 N#CC(c1cccnc1)N1CCN(C(=O)CNCc2ccccc2)CC1 10.1021/jm00100a018
CHEMBL3217094 20217 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 349 6 1 5 1.6 N#CC(c1cccnc1)N1CCN(C(=O)CNCc2ccccc2)CC1 10.1021/jm00100a018
9999670 20320 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 377 6 0 5 2.5 CC(c1ccccc1)N(C)CC(=O)N1CCN(C(C#N)c2cccnc2)CC1 10.1021/jm00100a018
CHEMBL1193836 20320 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 377 6 0 5 2.5 CC(c1ccccc1)N(C)CC(=O)N1CCN(C(C#N)c2cccnc2)CC1 10.1021/jm00100a018
CHEMBL545306 20320 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 377 6 0 5 2.5 CC(c1ccccc1)N(C)CC(=O)N1CCN(C(C#N)c2cccnc2)CC1 10.1021/jm00100a018
9981367 26391 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 453 9 1 5 3.6 N#CC(c1cccnc1)N1CCN(CC(=O)NCCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL130034 26391 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 453 9 1 5 3.6 N#CC(c1cccnc1)N1CCN(CC(=O)NCCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
10092996 30932 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 410 5 0 4 3.8 CC(C#N)(c1cccnc1)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL133921 30932 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 410 5 0 4 3.8 CC(C#N)(c1cccnc1)N1CCN(C(=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
3013157 104111 3 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 603 13 1 10 3.2 CCCCNC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL269340 104111 3 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 603 13 1 10 3.2 CCCCNC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
14554129 17307 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 366 1 0 2 4.7 CCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 10.1021/jm00105a069
CHEMBL116935 17307 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 366 1 0 2 4.7 CCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 10.1021/jm00105a069
14785936 18234 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 484 25 0 3 8.3 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCC[N+](C)(C)C)O1 10.1021/jm00105a058
CHEMBL1180375 18234 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 484 25 0 3 8.3 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCC[N+](C)(C)C)O1 10.1021/jm00105a058
CHEMBL124312 18234 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 484 25 0 3 8.3 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCC[N+](C)(C)C)O1 10.1021/jm00105a058
15123188 18492 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 533 20 0 6 5.6 C=CCCCCCCOCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL1181272 18492 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 533 20 0 6 5.6 C=CCCCCCCOCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL161127 18492 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 533 20 0 6 5.6 C=CCCCCCCOCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
15005373 115996 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 595 7 2 9 5.6 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccc(C#N)cc1 10.1021/jm00095a005
CHEMBL321722 115996 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 595 7 2 9 5.6 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccc(C#N)cc1 10.1021/jm00095a005
168283401 197669 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at PAFR (unknown origin)Antagonist activity at PAFR (unknown origin)
ChEMBL 286 0 0 2 4.4 C=C1C2=CC[C@@H](C)[C@@]1(C)CC/C(C)=C/CC[C@H]1O[C@@H]1C2=O 10.1016/j.ejmech.2020.112957
CHEMBL5184957 197669 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at PAFR (unknown origin)Antagonist activity at PAFR (unknown origin)
ChEMBL 286 0 0 2 4.4 C=C1C2=CC[C@@H](C)[C@@]1(C)CC/C(C)=C/CC[C@H]1O[C@@H]1C2=O 10.1016/j.ejmech.2020.112957
9996872 172216 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 332 4 0 4 2.5 N#CC(c1cccnc1)N1CCN(C(=O)/C=C/c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL423891 172216 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 332 4 0 4 2.5 N#CC(c1cccnc1)N1CCN(C(=O)/C=C/c2ccccc2)CC1 10.1021/jm00100a018
14786011 18284 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 589 24 0 5 8.2 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2ccc[n+](CC)c2)C(C)=O)C1 10.1021/jm00105a058
CHEMBL1180475 18284 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 589 24 0 5 8.2 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2ccc[n+](CC)c2)C(C)=O)C1 10.1021/jm00105a058
CHEMBL127374 18284 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 589 24 0 5 8.2 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2ccc[n+](CC)c2)C(C)=O)C1 10.1021/jm00105a058
10247684 20319 0 None - 1 Guinea pig 4.6 pIC50 = 4.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 356 3 0 4 3.3 N#CC(c1cccnc1)N1CCN(C(=O)c2ccc3ccccc3c2)CC1 10.1021/jm00100a018
CHEMBL1193834 20319 0 None - 1 Guinea pig 4.6 pIC50 = 4.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 356 3 0 4 3.3 N#CC(c1cccnc1)N1CCN(C(=O)c2ccc3ccccc3c2)CC1 10.1021/jm00100a018
CHEMBL3215754 20319 0 None - 1 Guinea pig 4.6 pIC50 = 4.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 356 3 0 4 3.3 N#CC(c1cccnc1)N1CCN(C(=O)c2ccc3ccccc3c2)CC1 10.1021/jm00100a018
10386994 29593 0 None - 1 Guinea pig 4.6 pIC50 = 4.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 412 6 0 4 4.0 Cn1cccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL132821 29593 0 None - 1 Guinea pig 4.6 pIC50 = 4.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 412 6 0 4 4.0 Cn1cccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
462383 209785 5 None - 1 Guinea pig 4.6 pIC50 = 4.6 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 603 12 0 10 3.2 CCN(CC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL6322 209785 5 None - 1 Guinea pig 4.6 pIC50 = 4.6 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 603 12 0 10 3.2 CCN(CC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
107681 8004 29 None -45 2 Guinea pig 4.6 pIC50 = 4.6 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 592 27 1 8 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)(OCC[n+]1ccsc1)[O-])OC 10.1021/jm00057a008
6079 8004 29 None -45 2 Guinea pig 4.6 pIC50 = 4.6 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 592 27 1 8 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)(OCC[n+]1ccsc1)[O-])OC 10.1021/jm00057a008
CHEMBL295212 8004 29 None -45 2 Guinea pig 4.6 pIC50 = 4.6 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 592 27 1 8 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)(OCC[n+]1ccsc1)[O-])OC 10.1021/jm00057a008
10025488 20641 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 426 6 0 5 4.2 N#CC(c1cccnc1)N1CCN(C(=O)OCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL1196008 20641 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 426 6 0 5 4.2 N#CC(c1cccnc1)N1CCN(C(=O)OCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL3217088 20641 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 426 6 0 5 4.2 N#CC(c1cccnc1)N1CCN(C(=O)OCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
14966970 31188 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 407 5 0 3 5.2 N#CC(=C1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1)c1cccnc1 10.1021/jm00100a018
CHEMBL134143 31188 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 407 5 0 3 5.2 N#CC(=C1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1)c1cccnc1 10.1021/jm00100a018
135492593 117443 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 385 2 1 7 3.2 Cc1nn(C)c2c1N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)CC(=O)N2 10.1021/jm00018a012
CHEMBL325928 117443 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 385 2 1 7 3.2 Cc1nn(C)c2c1N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)CC(=O)N2 10.1021/jm00018a012
10074233 115122 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 488 7 0 6 3.3 Cc1ncccc1C(C#N)N1CCN(C(=O)CS(=O)(=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL319806 115122 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 488 7 0 6 3.3 Cc1ncccc1C(C#N)N1CCN(C(=O)CS(=O)(=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
10322496 11493 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 470 6 0 4 5.0 Cc1ncccc1C(C#N)N1CCN(C(=O)C(C)(C)C(F)(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL103560 11493 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 470 6 0 4 5.0 Cc1ncccc1C(C#N)N1CCN(C(=O)C(C)(C)C(F)(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
10410007 11540 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 422 5 0 4 4.2 Cc1ncccc1C(C#N)N1CCN(C(=O)C=C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL103903 11540 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 422 5 0 4 4.2 Cc1ncccc1C(C#N)N1CCN(C(=O)C=C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
44350398 18250 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 592 22 1 8 5.8 CCCCCCCCCCCCCCCNOC(=O)CC1OCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL1180400 18250 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 592 22 1 8 5.8 CCCCCCCCCCCCCCCNOC(=O)CC1OCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL125411 18250 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 592 22 1 8 5.8 CCCCCCCCCCCCCCCNOC(=O)CC1OCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
10383132 122780 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 348 6 0 4 2.8 N#CC(c1cccnc1)N1CCN(C(=O)CCCc2ccccc2)CC1 10.1021/jm00100a018
CHEMBL335556 122780 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 348 6 0 4 2.8 N#CC(c1cccnc1)N1CCN(C(=O)CCCc2ccccc2)CC1 10.1021/jm00100a018
15123182 18464 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 517 11 0 5 5.1 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCC(c2ccccc2)c2ccccc2)C1 10.1021/jm00082a007
CHEMBL1181204 18464 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 517 11 0 5 5.1 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCC(c2ccccc2)c2ccccc2)C1 10.1021/jm00082a007
CHEMBL158907 18464 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 517 11 0 5 5.1 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCC(c2ccccc2)c2ccccc2)C1 10.1021/jm00082a007
10064545 118046 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 319 2 2 5 1.8 Cc1nc2cnccc2n1-c1ccc(C2=CC(=O)NCCN2)cc1 10.1021/jm00018a011
CHEMBL326517 118046 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 319 2 2 5 1.8 Cc1nc2cnccc2n1-c1ccc(C2=CC(=O)NCCN2)cc1 10.1021/jm00018a011
10249498 19886 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 385 5 1 5 3.1 N#CC(c1cccnc1)N1CCN(C(=O)CNc2cccc3ccccc23)CC1 10.1021/jm00100a018
CHEMBL1190421 19886 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 385 5 1 5 3.1 N#CC(c1cccnc1)N1CCN(C(=O)CNc2cccc3ccccc23)CC1 10.1021/jm00100a018
CHEMBL540829 19886 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 385 5 1 5 3.1 N#CC(c1cccnc1)N1CCN(C(=O)CNc2cccc3ccccc23)CC1 10.1021/jm00100a018
14966961 20647 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 425 7 0 5 4.9 N#CC(c1cccnc1)N1CCC(OC(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL1196065 20647 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 425 7 0 5 4.9 N#CC(c1cccnc1)N1CCC(OC(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL3216875 20647 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 425 7 0 5 4.9 N#CC(c1cccnc1)N1CCC(OC(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
1131684 30556 16 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 371 5 0 3 3.6 O=C(C(c1ccccc1)c1ccccc1)N1CCN(Cc2cccnc2)CC1 10.1021/jm00100a018
CHEMBL133586 30556 16 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 371 5 0 3 3.6 O=C(C(c1ccccc1)c1ccccc1)N1CCN(Cc2cccnc2)CC1 10.1021/jm00100a018
10025387 30981 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 424 7 0 4 4.2 N#CC(c1cccnc1)N1CCN(C(=O)C(CCc2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL133964 30981 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 424 7 0 4 4.2 N#CC(c1cccnc1)N1CCN(C(=O)C(CCc2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
10364365 32042 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 412 6 0 4 4.0 Cn1ccc(C(C#N)N2CCN(C(=O)CC(c3ccccc3)c3ccccc3)CC2)c1 10.1021/jm00100a018
CHEMBL134877 32042 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 412 6 0 4 4.0 Cn1ccc(C(C#N)N2CCN(C(=O)CC(c3ccccc3)c3ccccc3)CC2)c1 10.1021/jm00100a018
10446714 174243 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 286 5 0 4 2.0 CCCCC(=O)N1CCN(C(C#N)c2cccnc2)CC1 10.1021/jm00100a018
CHEMBL429877 174243 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 286 5 0 4 2.0 CCCCC(=O)N1CCN(C(C#N)c2cccnc2)CC1 10.1021/jm00100a018
10095628 215174 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 457 7 1 6 3.3 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)c2ccoc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL99621 215174 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 457 7 1 6 3.3 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)c2ccoc2)c2ccccc2)CC1 10.1021/jm00072a019
14992351 176234 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 647 25 0 8 8.1 CCCCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)OC)c1 10.1021/jm00087a023
CHEMBL44281 176234 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 647 25 0 8 8.1 CCCCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)OC)c1 10.1021/jm00087a023
14785874 18239 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 466 22 0 3 8.1 CCCCCCCCCCCCCCC1COC(COCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL1180381 18239 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 466 22 0 3 8.1 CCCCCCCCCCCCCCC1COC(COCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL124535 18239 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 466 22 0 3 8.1 CCCCCCCCCCCCCCC1COC(COCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
14786017 18707 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 575 23 0 5 7.4 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(CCc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL1182753 18707 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 575 23 0 5 7.4 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(CCc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL264467 18707 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 575 23 0 5 7.4 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(CCc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
14992479 108255 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 615 21 0 7 8.6 CCCCCCCCCCCCCCOc1cc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)cc(C(C)=O)c1 10.1021/jm00087a023
CHEMBL297797 108255 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 615 21 0 7 8.6 CCCCCCCCCCCCCCOc1cc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)cc(C(C)=O)c1 10.1021/jm00087a023
44350400 18930 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 618 24 1 7 7.2 CCCCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL1184190 18930 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 618 24 1 7 7.2 CCCCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL338345 18930 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 618 24 1 7 7.2 CCCCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
15005362 117978 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 635 8 2 10 5.8 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4c(OC)ncnc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL326474 117978 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 635 8 2 10 5.8 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4c(OC)ncnc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
21463453 18743 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 611 27 1 6 8.9 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccsc2)CSC1 10.1016/0960-894X(95)00173-Q
CHEMBL1182988 18743 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 611 27 1 6 8.9 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccsc2)CSC1 10.1016/0960-894X(95)00173-Q
CHEMBL274843 18743 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 611 27 1 6 8.9 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccsc2)CSC1 10.1016/0960-894X(95)00173-Q
10318877 115409 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 401 7 1 5 2.5 C#CCNC(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccccc1 10.1021/jm00072a019
CHEMBL320676 115409 0 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 401 7 1 5 2.5 C#CCNC(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccccc1 10.1021/jm00072a019
10403733 29530 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 320 4 0 4 2.0 N#CC(c1cccnc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm00100a018
CHEMBL132780 29530 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 320 4 0 4 2.0 N#CC(c1cccnc1)N1CCN(C(=O)Cc2ccccc2)CC1 10.1021/jm00100a018
10370881 168553 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 574 15 0 10 4.4 CCC(CC)C(=O)OCC1CN(Cc2cc(OC)c(OC)c(OC)c2)CCN1Cc1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL414007 168553 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 574 15 0 10 4.4 CCC(CC)C(=O)OCC1CN(Cc2cc(OC)c(OC)c(OC)c2)CCN1Cc1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
14785934 18245 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 554 25 0 3 9.7 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCC[n+]2cccc3ccccc32)O1 10.1021/jm00105a058
CHEMBL1180390 18245 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 554 25 0 3 9.7 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCC[n+]2cccc3ccccc32)O1 10.1021/jm00105a058
CHEMBL124980 18245 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 554 25 0 3 9.7 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCC[n+]2cccc3ccccc32)O1 10.1021/jm00105a058
14992499 176269 0 None - 1 Guinea pig 4.6 pIC50 = 4.6 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 403 6 0 5 4.3 CC(C)(C)c1ccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)cc1 10.1021/jm00087a023
CHEMBL44316 176269 0 None - 1 Guinea pig 4.6 pIC50 = 4.6 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 403 6 0 5 4.3 CC(C)(C)c1ccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)cc1 10.1021/jm00087a023
15005346 117466 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cccnc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL326012 117466 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cccnc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
10048850 11037 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 439 7 1 5 4.3 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(Nc2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL100547 11037 0 None - 1 Guinea pig 7.6 pIC50 = 7.6 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 439 7 1 5 4.3 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(Nc2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
460131 104081 4 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 631 13 1 10 3.9 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)NC(C)CC(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL269132 104081 4 None - 1 Guinea pig 6.6 pIC50 = 6.6 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 631 13 1 10 3.9 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)NC(C)CC(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
11450461 96305 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at PAFR (unknown origin)Antagonist activity at PAFR (unknown origin)
ChEMBL 334 0 2 4 3.1 C/C1=C\CC[C@]2(C)O[C@@H]3C[C@@H](C)[C@@](C)(CC1)C1=C3[C@](O)(OC1)[C@H]2O 10.1016/j.ejmech.2020.112957
CHEMBL2373416 96305 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at PAFR (unknown origin)Antagonist activity at PAFR (unknown origin)
ChEMBL 334 0 2 4 3.1 C/C1=C\CC[C@]2(C)O[C@@H]3C[C@@H](C)[C@@](C)(CC1)C1=C3[C@](O)(OC1)[C@H]2O 10.1016/j.ejmech.2020.112957
168273696 197187 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at PAFR (unknown origin)Antagonist activity at PAFR (unknown origin)
ChEMBL 350 0 2 5 2.1 C[C@@H]1[C@@H](O)C=C2C(=O)[C@H]3O[C@@]3(C)CCC[C@H]3O[C@@]3(C)C[C@]1(C)[C@@]2(C)O 10.1016/j.ejmech.2020.112957
CHEMBL5177763 197187 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at PAFR (unknown origin)Antagonist activity at PAFR (unknown origin)
ChEMBL 350 0 2 5 2.1 C[C@@H]1[C@@H](O)C=C2C(=O)[C@H]3O[C@@]3(C)CCC[C@H]3O[C@@]3(C)C[C@]1(C)[C@@]2(C)O 10.1016/j.ejmech.2020.112957
168271435 197382 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at PAFR (unknown origin)Antagonist activity at PAFR (unknown origin)
ChEMBL 304 0 1 3 3.4 C/C1=C\CC[C@@H]2O[C@H]2C(=O)C2=CC[C@@H](C)[C@@](C)(C[C@@H]1O)[C@@H]2C 10.1016/j.ejmech.2020.112957
CHEMBL5180736 197382 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at PAFR (unknown origin)Antagonist activity at PAFR (unknown origin)
ChEMBL 304 0 1 3 3.4 C/C1=C\CC[C@@H]2O[C@H]2C(=O)C2=CC[C@@H](C)[C@@](C)(C[C@@H]1O)[C@@H]2C 10.1016/j.ejmech.2020.112957
168280492 197532 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at PAFR (unknown origin)Antagonist activity at PAFR (unknown origin)
ChEMBL 334 0 1 4 3.2 C[C@@H]1CC=C2C(=O)[C@H]3O[C@]3(C)CC[C@@H]3O[C@@]3(C)CC[C@@]1(C)[C@@]2(C)O 10.1016/j.ejmech.2020.112957
CHEMBL5182952 197532 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at PAFR (unknown origin)Antagonist activity at PAFR (unknown origin)
ChEMBL 334 0 1 4 3.2 C[C@@H]1CC=C2C(=O)[C@H]3O[C@]3(C)CC[C@@H]3O[C@@]3(C)CC[C@@]1(C)[C@@]2(C)O 10.1016/j.ejmech.2020.112957
132820021 198883 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at PAFR (unknown origin)Antagonist activity at PAFR (unknown origin)
ChEMBL 316 0 0 3 4.0 C=C1C2=CC[C@@H](C)[C@]1(C)CC[C@]1(C)O[C@H]1CC[C@@]1(C)O[C@@H]1C2=O 10.1016/j.ejmech.2020.112957
CHEMBL5203145 198883 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at PAFR (unknown origin)Antagonist activity at PAFR (unknown origin)
ChEMBL 316 0 0 3 4.0 C=C1C2=CC[C@@H](C)[C@]1(C)CC[C@]1(C)O[C@H]1CC[C@@]1(C)O[C@@H]1C2=O 10.1016/j.ejmech.2020.112957
163112293 199279 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at PAFR (unknown origin)Antagonist activity at PAFR (unknown origin)
ChEMBL 318 0 0 3 4.1 C[C@@H]1CC=C2C(=O)[C@H]3O[C@]3(C)CC[C@@H]3O[C@@]3(C)CC[C@@]1(C)[C@@H]2C 10.1016/j.ejmech.2020.112957
CHEMBL5209111 199279 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at PAFR (unknown origin)Antagonist activity at PAFR (unknown origin)
ChEMBL 318 0 0 3 4.1 C[C@@H]1CC=C2C(=O)[C@H]3O[C@]3(C)CC[C@@H]3O[C@@]3(C)CC[C@@]1(C)[C@@H]2C 10.1016/j.ejmech.2020.112957
10042993 17646 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 342 2 1 7 3.1 Cc1nc2cnccc2n1-c1ccc(-c2cc(O)n3nccc3n2)cc1 10.1021/jm00018a011
CHEMBL117250 17646 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 342 2 1 7 3.1 Cc1nc2cnccc2n1-c1ccc(-c2cc(O)n3nccc3n2)cc1 10.1021/jm00018a011
11725381 20538 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 349 5 0 5 1.9 CN(CC(=O)N1CCN(C(C#N)c2cccnc2)CC1)c1ccccc1 10.1021/jm00100a018
CHEMBL1195359 20538 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 349 5 0 5 1.9 CN(CC(=O)N1CCN(C(C#N)c2cccnc2)CC1)c1ccccc1 10.1021/jm00100a018
CHEMBL554398 20538 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 349 5 0 5 1.9 CN(CC(=O)N1CCN(C(C#N)c2cccnc2)CC1)c1ccccc1 10.1021/jm00100a018
15123167 18470 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 351 7 0 5 1.9 CCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL1181210 18470 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 351 7 0 5 1.9 CCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL159055 18470 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 351 7 0 5 1.9 CCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
14786019 18928 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 533 23 1 4 7.2 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)NCCc2cccc[n+]2CC)C1 10.1021/jm00105a058
CHEMBL1184187 18928 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 533 23 1 4 7.2 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)NCCc2cccc[n+]2CC)C1 10.1021/jm00105a058
CHEMBL338260 18928 0 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 533 23 1 4 7.2 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)NCCc2cccc[n+]2CC)C1 10.1021/jm00105a058
14885642 38938 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 326 2 0 2 4.2 CC(=O)N1CCC(=C(c2ccc(Cl)cc2)c2ccccn2)CC1 10.1021/jm00105a069
CHEMBL140919 38938 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 326 2 0 2 4.2 CC(=O)N1CCC(=C(c2ccc(Cl)cc2)c2ccccn2)CC1 10.1021/jm00105a069
3075897 103725 9 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 658 18 0 10 5.4 CCCCCCCCCC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL266184 103725 9 None - 1 Guinea pig 5.6 pIC50 = 5.6 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 658 18 0 10 5.4 CCCCCCCCCC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
14992359 108252 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 631 24 0 7 8.3 CCCCCCCCCCCCCCc1ccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)OC)cc1 10.1021/jm00087a023
CHEMBL297778 108252 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 631 24 0 7 8.3 CCCCCCCCCCCCCCc1ccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)OC)cc1 10.1021/jm00087a023
21463436 17897 0 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 645 24 1 5 9.4 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178061 17897 0 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 645 24 1 5 9.4 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL12382 17897 0 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 645 24 1 5 9.4 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCCC1 10.1016/0960-894X(95)00173-Q
14992337 108284 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 633 23 0 8 7.7 CCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)OC)c1C 10.1021/jm00087a023
CHEMBL297988 108284 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 633 23 0 8 7.7 CCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)OC)c1C 10.1021/jm00087a023
10458039 10989 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 484 7 2 7 2.8 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)c2cccnc2O)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL100281 10989 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 484 7 2 7 2.8 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)c2cccnc2O)c2ccccc2)CC1 10.1021/jm00072a019
9987194 17904 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 659 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)N1C(C)=O 10.1016/0960-894X(95)00174-R
CHEMBL1178075 17904 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 659 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)N1C(C)=O 10.1016/0960-894X(95)00174-R
CHEMBL12558 17904 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 659 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)N1C(C)=O 10.1016/0960-894X(95)00174-R
3075902 102485 9 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 602 14 0 10 3.8 CCCCCC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL258253 102485 9 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 602 14 0 10 3.8 CCCCCC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
3075895 104004 4 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 614 11 0 10 3.8 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)C3CCCCC3)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL268597 104004 4 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 614 11 0 10 3.8 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)C3CCCCC3)C2)cc(OC)c1OC 10.1021/jm00060a006
10372227 18082 1 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 536 24 0 5 8.2 CCCCCCCCCCCCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL1179274 18082 1 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 536 24 0 5 8.2 CCCCCCCCCCCCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL67302 18082 1 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 536 24 0 5 8.2 CCCCCCCCCCCCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
14992461 179328 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 607 20 0 6 9.1 CCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)cc1Cl 10.1021/jm00087a023
CHEMBL44844 179328 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 607 20 0 6 9.1 CCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)cc1Cl 10.1021/jm00087a023
CHEMBL104290 11621 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 585 10 2 8 6.4 CCO/C(O)=C1\C(COCCn2c(C)nc3ccccc32)=NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
15005375 117477 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 626 7 2 9 6.9 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1csc2ccccc12 10.1021/jm00095a005
CHEMBL326039 117477 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 626 7 2 9 6.9 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1csc2ccccc12 10.1021/jm00095a005
10480355 19329 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 481 5 0 7 4.1 CCN(CC)C(=O)c1cnc2c(c1)N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)CC(=O)N2C 10.1021/jm00018a012
CHEMBL118672 19329 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 481 5 0 7 4.1 CCN(CC)C(=O)c1cnc2c(c1)N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)CC(=O)N2C 10.1021/jm00018a012
15005365 12053 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 583 6 2 7 6.2 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)NC(C)(C)C)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL106526 12053 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 583 6 2 7 6.2 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)NC(C)(C)C)C1c1ccccc1Cl 10.1021/jm00095a005
15005374 114239 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 614 7 2 10 5.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1cccc2c1OCO2 10.1021/jm00095a005
CHEMBL318348 114239 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 614 7 2 10 5.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1cccc2c1OCO2 10.1021/jm00095a005
15005357 116534 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 618 8 2 8 6.6 CCOC(=O)C1=C(c2ccc(-n3c(CC)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL323067 116534 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 618 8 2 8 6.6 CCOC(=O)C1=C(c2ccc(-n3c(CC)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
10339861 19092 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 382 2 0 6 3.6 Cc1nc2cnccc2n1-c1ccc(C2=Nc3cccnc3N(C)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL118511 19092 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 382 2 0 6 3.6 Cc1nc2cnccc2n1-c1ccc(C2=Nc3cccnc3N(C)C(=O)C2)cc1 10.1021/jm00018a012
10342483 19540 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 427 3 0 7 4.1 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(C(C)C)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL118793 19540 0 None - 1 Guinea pig 8.5 pIC50 = 8.5 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 427 3 0 7 4.1 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(C(C)C)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
15005358 116525 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 658 7 2 8 7.1 CCOC(=O)C1=C(c2ccc(-n3c(C(F)(F)F)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL323023 116525 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 658 7 2 8 7.1 CCOC(=O)C1=C(c2ccc(-n3c(C(F)(F)F)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
10365462 10974 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 431 6 0 5 2.9 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)N2CCCC2=O)CC1 10.1021/jm00072a019
CHEMBL100190 10974 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 431 6 0 5 2.9 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)N2CCCC2=O)CC1 10.1021/jm00072a019
10366660 11464 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 453 7 1 5 3.9 Cc1ncccc1C(C#N)N1CCN(C(=O)[C@@H](C)NC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL103408 11464 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 453 7 1 5 3.9 Cc1ncccc1C(C#N)N1CCN(C(=O)[C@@H](C)NC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
10050241 11495 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 467 8 0 5 3.3 Cc1ncccc1C(C#N)N1CCN(C(=O)CN(C=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL103571 11495 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 467 8 0 5 3.3 Cc1ncccc1C(C#N)N1CCN(C(=O)CN(C=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
14992477 185854 0 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 615 21 0 7 8.6 CCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(C(C)=O)c1 10.1021/jm00087a023
CHEMBL47159 185854 0 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 615 21 0 7 8.6 CCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(C(C)=O)c1 10.1021/jm00087a023
5312127 70093 1 None -23 2 Guinea pig 6.5 pIC50 = 6.5 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 480 10 0 8 4.5 CCCOc1c(OC)cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(C)(=O)=O 10.1021/jm00060a006
CHEMBL1793831 70093 1 None -23 2 Guinea pig 6.5 pIC50 = 6.5 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 480 10 0 8 4.5 CCCOc1c(OC)cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(C)(=O)=O 10.1021/jm00060a006
15005343 116547 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 568 7 2 8 5.5 CCOC(=O)C1=C(c2ccc(-n3nc(C)nc3C)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL323151 116547 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 568 7 2 8 5.5 CCOC(=O)C1=C(c2ccc(-n3nc(C)nc3C)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
14992515 185226 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 645 23 0 7 9.3 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3CC(C)C)c2)c1OC 10.1021/jm00087a023
CHEMBL46615 185226 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 645 23 0 7 9.3 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3CC(C)C)c2)c1OC 10.1021/jm00087a023
14785932 18232 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 504 25 0 3 8.6 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCC[n+]2ccccc2)O1 10.1021/jm00105a058
CHEMBL1180368 18232 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 504 25 0 3 8.6 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCC[n+]2ccccc2)O1 10.1021/jm00105a058
CHEMBL124184 18232 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 504 25 0 3 8.6 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCC[n+]2ccccc2)O1 10.1021/jm00105a058
14785920 18942 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 496 22 0 5 7.4 CCCCCCCCCCCCCCCC1OCC(COC(=O)CCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL1184206 18942 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 496 22 0 5 7.4 CCCCCCCCCCCCCCCC1OCC(COC(=O)CCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL338883 18942 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 496 22 0 5 7.4 CCCCCCCCCCCCCCCC1OCC(COC(=O)CCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
44374375 18488 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 575 23 0 5 8.1 CCCCCCCCCCCCCCCCCCO[C@@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL1181265 18488 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 575 23 0 5 8.1 CCCCCCCCCCCCCCCCCCO[C@@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL160994 18488 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 575 23 0 5 8.1 CCCCCCCCCCCCCCCCCCO[C@@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
10001344 11378 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 405 6 1 5 2.4 CC(=O)NC(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccccc1 10.1021/jm00072a019
CHEMBL102774 11378 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 405 6 1 5 2.4 CC(=O)NC(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccccc1 10.1021/jm00072a019
129796 107232 39 None -1 2 Human 7.5 pIC50 = 7.5 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
CHEMBL29067 107232 39 None -1 2 Human 7.5 pIC50 = 7.5 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
3075896 209553 6 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 630 16 0 10 4.6 CCCCCCCC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL6211 209553 6 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 630 16 0 10 4.6 CCCCCCCC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
23042919 18249 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 524 25 0 4 8.9 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCC[n+]2cscc2C)O1 10.1021/jm00105a058
CHEMBL1180397 18249 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 524 25 0 4 8.9 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCC[n+]2cscc2C)O1 10.1021/jm00105a058
CHEMBL125315 18249 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 524 25 0 4 8.9 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCC[n+]2cscc2C)O1 10.1021/jm00105a058
14785861 18949 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 494 22 0 4 8.2 CCCCCCCCCCCCCCCC1CCC(COC(=O)CCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL1184216 18949 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 494 22 0 4 8.2 CCCCCCCCCCCCCCCC1CCC(COC(=O)CCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL339676 18949 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 494 22 0 4 8.2 CCCCCCCCCCCCCCCC1CCC(COC(=O)CCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
10026203 20245 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 439 8 0 5 3.5 N#CC(c1cccnc1)N1CCN(C(=O)CN(Cc2ccccc2)Cc2ccccc2)CC1 10.1021/jm00100a018
CHEMBL1193235 20245 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 439 8 0 5 3.5 N#CC(c1cccnc1)N1CCN(C(=O)CN(Cc2ccccc2)Cc2ccccc2)CC1 10.1021/jm00100a018
CHEMBL544607 20245 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 439 8 0 5 3.5 N#CC(c1cccnc1)N1CCN(C(=O)CN(Cc2ccccc2)Cc2ccccc2)CC1 10.1021/jm00100a018
10411043 11034 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 441 6 1 6 2.8 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(O)(c2ccccc2)c2cccnc2)CC1 10.1021/jm00072a019
CHEMBL100522 11034 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 441 6 1 6 2.8 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(O)(c2ccccc2)c2cccnc2)CC1 10.1021/jm00072a019
10384056 114045 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 362 5 0 4 3.3 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(C)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL316969 114045 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 362 5 0 4 3.3 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(C)c2ccccc2)CC1 10.1021/jm00072a019
10461497 103809 0 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 617 12 1 10 3.6 CCC(C)(C)NC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL266886 103809 0 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 617 12 1 10 3.6 CCC(C)(C)NC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
15005377 12189 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 571 7 2 9 5.1 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1cccnc1 10.1021/jm00095a005
CHEMBL107241 12189 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 571 7 2 9 5.1 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1cccnc1 10.1021/jm00095a005
14785952 18244 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 618 24 1 7 7.3 CCCCCCCCCCCCCCCCCNOC(=O)CC1CCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL1180388 18244 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 618 24 1 7 7.3 CCCCCCCCCCCCCCCCCNOC(=O)CC1CCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL124906 18244 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 618 24 1 7 7.3 CCCCCCCCCCCCCCCCCNOC(=O)CC1CCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
14992339 36124 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 633 23 0 8 7.7 CCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2ccccc2C[n+]2ccsc2)OC)c1C 10.1021/jm00087a023
CHEMBL13835 36124 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 633 23 0 8 7.7 CCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2ccccc2C[n+]2ccsc2)OC)c1C 10.1021/jm00087a023
122159 108131 19 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 356 6 0 5 3.8 C=CCC1=C[C@@]2(OC)C(=CC1=O)O[C@H](c1ccc(OC)c(OC)c1)[C@H]2C 10.1021/jm00057a008
CHEMBL296958 108131 19 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 356 6 0 5 3.8 C=CCC1=C[C@@]2(OC)C(=CC1=O)O[C@H](c1ccc(OC)c(OC)c1)[C@H]2C 10.1021/jm00057a008
14554127 120102 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 380 2 0 2 5.1 CCCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 10.1021/jm00105a069
CHEMBL331603 120102 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 380 2 0 2 5.1 CCCC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1 10.1021/jm00105a069
14992507 108306 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 603 21 0 7 8.4 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3cscc3C)c2)c1OC 10.1021/jm00087a023
CHEMBL298209 108306 0 None - 1 Guinea pig 5.5 pIC50 = 5.5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 603 21 0 7 8.4 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3cscc3C)c2)c1OC 10.1021/jm00087a023
10389948 215196 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 469 8 2 6 2.8 Cc1ncccc1C(C#N)N1CCN(C(=O)[C@H](CO)NC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL99795 215196 0 None - 1 Guinea pig 7.5 pIC50 = 7.5 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 469 8 2 6 2.8 Cc1ncccc1C(C#N)N1CCN(C(=O)[C@H](CO)NC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
14885632 27775 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 348 1 0 3 3.6 COc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C(C)=O)CC1 10.1021/jm00105a069
CHEMBL131155 27775 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 348 1 0 3 3.6 COc1ccc2c(c1)CCc1cccnc1C2=C1CCN(C(C)=O)CC1 10.1021/jm00105a069
14885627 121598 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 352 0 0 2 4.3 CC(=O)N1CCC(=C2c3cc(Cl)ccc3CCc3cccnc32)CC1 10.1021/jm00105a069
CHEMBL334127 121598 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 352 0 0 2 4.3 CC(=O)N1CCC(=C2c3cc(Cl)ccc3CCc3cccnc32)CC1 10.1021/jm00105a069
10404046 16903 0 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 325 2 1 4 4.3 Cc1nc2cnccc2n1-c1ccc(-c2nc3ccccc3[nH]2)cc1 10.1021/jm00018a011
CHEMBL115695 16903 0 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 325 2 1 4 4.3 Cc1nc2cnccc2n1-c1ccc(-c2nc3ccccc3[nH]2)cc1 10.1021/jm00018a011
10341675 114097 0 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 413 6 0 5 3.6 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)n2cccc2)CC1 10.1021/jm00072a019
CHEMBL317380 114097 0 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 413 6 0 5 3.6 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)n2cccc2)CC1 10.1021/jm00072a019
9918334 18733 0 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 602 22 1 5 8.2 CCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL1182944 18733 0 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 602 22 1 5 8.2 CCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL273639 18733 0 None - 1 Guinea pig 6.5 pIC50 = 6.5 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 602 22 1 5 8.2 CCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCC1 10.1016/0960-894X(95)00173-Q
14992529 179530 0 None - 1 Guinea pig 4.5 pIC50 = 4.5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 605 24 0 6 9.1 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[N+](CC)(CC)CC)c2)c1OC 10.1021/jm00087a023
CHEMBL45092 179530 0 None - 1 Guinea pig 4.5 pIC50 = 4.5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 605 24 0 6 9.1 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[N+](CC)(CC)CC)c2)c1OC 10.1021/jm00087a023
10090118 20550 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 363 6 1 5 2.1 CC(NCC(=O)N1CCN(C(C#N)c2cccnc2)CC1)c1ccccc1 10.1021/jm00100a018
CHEMBL1195412 20550 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 363 6 1 5 2.1 CC(NCC(=O)N1CCN(C(C#N)c2cccnc2)CC1)c1ccccc1 10.1021/jm00100a018
CHEMBL554463 20550 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 363 6 1 5 2.1 CC(NCC(=O)N1CCN(C(C#N)c2cccnc2)CC1)c1ccccc1 10.1021/jm00100a018
10319443 20620 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 411 8 1 5 3.6 N#CC(c1ccncc1)N1CCN(CCNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL1195908 20620 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 411 8 1 5 3.6 N#CC(c1ccncc1)N1CCN(CCNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL555567 20620 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 411 8 1 5 3.6 N#CC(c1ccncc1)N1CCN(CCNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
10433324 123397 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 439 8 1 5 3.2 N#CC(c1cccnc1)N1CCN(CCNC(=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL336816 123397 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 439 8 1 5 3.2 N#CC(c1cccnc1)N1CCN(CCNC(=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
10474804 215201 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 378 5 1 5 2.4 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(C)(O)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL99833 215201 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 378 5 1 5 2.4 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(C)(O)c2ccccc2)CC1 10.1021/jm00072a019
10050053 11458 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 463 8 1 6 3.6 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)OCC(C)C)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL103368 11458 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 463 8 1 6 3.6 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)OCC(C)C)c2ccccc2)CC1 10.1021/jm00072a019
10476736 28274 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 411 5 1 4 3.8 N#CC(c1cccnc1)N1CCN(C(=O)NC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL131597 28274 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 411 5 1 4 3.8 N#CC(c1cccnc1)N1CCN(C(=O)NC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
14785891 18932 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 538 25 0 5 8.0 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)CCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL1184193 18932 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 538 25 0 5 8.0 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)CCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL338475 18932 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 538 25 0 5 8.0 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)CCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
21463468 17891 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 659 24 1 5 9.8 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178049 17891 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 659 24 1 5 9.8 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL12067 17891 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 659 24 1 5 9.8 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCCCC1 10.1016/0960-894X(95)00173-Q
10372180 100805 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 659 17 1 10 4.8 CCCCCCCCNC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL24879 100805 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 659 17 1 10 4.8 CCCCCCCCNC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
10326598 18435 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 497 17 0 4 6.4 CCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2C)C(C)=O)cc1OCCCCCCC 10.1021/jm00057a008
CHEMBL1181104 18435 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 497 17 0 4 6.4 CCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2C)C(C)=O)cc1OCCCCCCC 10.1021/jm00057a008
CHEMBL155663 18435 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 497 17 0 4 6.4 CCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2C)C(C)=O)cc1OCCCCCCC 10.1021/jm00057a008
14785914 18270 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 538 27 0 4 9.4 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL1180447 18270 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 538 27 0 4 9.4 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL126523 18270 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 538 27 0 4 9.4 CCCCCCCCCCCCCCCCCC1OCC(COCCCCCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
10024551 21319 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 410 2 0 6 4.2 Cc1cc(C)c2c(n1)N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)CC(=O)N2C 10.1021/jm00018a012
CHEMBL120322 21319 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 410 2 0 6 4.2 Cc1cc(C)c2c(n1)N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)CC(=O)N2C 10.1021/jm00018a012
10072622 11521 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 453 8 1 5 3.7 CCc1ncccc1C(C#N)N1CCN(C(=O)CNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL103773 11521 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 453 8 1 5 3.7 CCc1ncccc1C(C#N)N1CCN(C(=O)CNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
457910 104080 1 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 631 14 0 10 4.0 CCCN(CCC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL269131 104080 1 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 631 14 0 10 4.0 CCCN(CCC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
14992373 187270 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 669 23 0 8 8.5 CCCCCCCCCCCCOc1ccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)OC)c2ccccc12 10.1021/jm00087a023
CHEMBL47531 187270 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 669 23 0 8 8.5 CCCCCCCCCCCCOc1ccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)OC)c2ccccc12 10.1021/jm00087a023
21463457 17887 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 595 27 1 6 8.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccsc2)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178043 17887 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 595 27 1 6 8.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccsc2)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL11962 17887 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 595 27 1 6 8.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccsc2)COC1 10.1016/0960-894X(95)00173-Q
14992396 16986 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 588 25 3 6 7.7 CCCCCCCCCCCCCCCCOCC(COP(=O)(O)Oc1cccc(C/N=C(\S)NC)c1)OC 10.1021/jm00087a023
CHEMBL1160079 16986 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 588 25 3 6 7.7 CCCCCCCCCCCCCCCCOCC(COP(=O)(O)Oc1cccc(C/N=C(\S)NC)c1)OC 10.1021/jm00087a023
10394593 209824 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 659 16 1 10 4.6 CCCCC(CC)CNC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL6350 209824 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 659 16 1 10 4.6 CCCCC(CC)CNC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
14785872 18285 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 566 29 0 4 9.7 CCCCCCCCCCCCCCCCCCOCC1CC(COCCCCCCC[n+]2ccsc2)CO1 10.1021/jm00105a058
CHEMBL1180477 18285 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 566 29 0 4 9.7 CCCCCCCCCCCCCCCCCCOCC1CC(COCCCCCCC[n+]2ccsc2)CO1 10.1021/jm00105a058
CHEMBL127417 18285 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 566 29 0 4 9.7 CCCCCCCCCCCCCCCCCCOCC1CC(COCCCCCCC[n+]2ccsc2)CO1 10.1021/jm00105a058
14785879 18255 0 None - 1 Guinea pig 4.4 pIC50 = 4.4 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 438 20 0 3 7.3 CCCCCCCCCCCCCCC1COC(COCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL1180406 18255 0 None - 1 Guinea pig 4.4 pIC50 = 4.4 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 438 20 0 3 7.3 CCCCCCCCCCCCCCC1COC(COCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL125513 18255 0 None - 1 Guinea pig 4.4 pIC50 = 4.4 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 438 20 0 3 7.3 CCCCCCCCCCCCCCC1COC(COCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
14992321 174607 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 583 25 0 7 7.5 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1ccc(C[n+]2ccsc2)cc1)OC 10.1021/jm00087a023
CHEMBL430741 174607 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 583 25 0 7 7.5 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1ccc(C[n+]2ccsc2)cc1)OC 10.1021/jm00087a023
44267821 17890 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 604 24 1 5 8.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(C)(C)COC(=O)N(Cc1cccc[n+]1CC)C(C)=O 10.1016/0960-894X(95)00173-Q
CHEMBL1178046 17890 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 604 24 1 5 8.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(C)(C)COC(=O)N(Cc1cccc[n+]1CC)C(C)=O 10.1016/0960-894X(95)00173-Q
CHEMBL12012 17890 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 604 24 1 5 8.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(C)(C)COC(=O)N(Cc1cccc[n+]1CC)C(C)=O 10.1016/0960-894X(95)00173-Q
14992387 108283 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 577 25 0 6 7.4 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2ccccc2)c1)OC 10.1021/jm00087a023
CHEMBL297974 108283 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 577 25 0 6 7.4 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2ccccc2)c1)OC 10.1021/jm00087a023
10094543 17091 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 435 2 1 5 4.9 Cc1nc2cnccc2n1-c1ccc(C2=Nc3cc(Cl)c(Cl)cc3C(=O)NC2)cc1 10.1021/jm00018a011
CHEMBL116198 17091 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 435 2 1 5 4.9 Cc1nc2cnccc2n1-c1ccc(C2=Nc3cc(Cl)c(Cl)cc3C(=O)NC2)cc1 10.1021/jm00018a011
10367028 19515 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 460 2 0 6 4.4 Cc1nc2cnccc2n1-c1ccc(C2=Nc3ncc(Br)cc3N(C)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL118780 19515 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 460 2 0 6 4.4 Cc1nc2cnccc2n1-c1ccc(C2=Nc3ncc(Br)cc3N(C)C(=O)C2)cc1 10.1021/jm00018a012
10433727 20420 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 446 2 1 6 4.3 Cc1nc2cnccc2n1-c1ccc(C2=Nc3cc(Br)cnc3NC(=O)C2)cc1 10.1021/jm00018a012
CHEMBL119452 20420 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 446 2 1 6 4.3 Cc1nc2cnccc2n1-c1ccc(C2=Nc3cc(Br)cnc3NC(=O)C2)cc1 10.1021/jm00018a012
10253671 119791 1 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 459 3 0 7 4.5 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(-c4ccccc4)nn4c3N(CC4)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL331124 119791 1 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 459 3 0 7 4.5 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(-c4ccccc4)nn4c3N(CC4)C(=O)C2)cc1 10.1021/jm00018a012
15123186 19150 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 563 22 0 6 6.6 CCCCCCCCCCOCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL1185572 19150 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 563 22 0 6 6.6 CCCCCCCCCCOCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL421843 19150 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 563 22 0 6 6.6 CCCCCCCCCCOCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
129796 107232 39 None 1 2 Guinea pig 8.4 pIC50 = 8.4 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00018a011
CHEMBL29067 107232 39 None 1 2 Guinea pig 8.4 pIC50 = 8.4 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00018a011
129796 107232 39 None 1 2 Guinea pig 8.4 pIC50 = 8.4 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00018a012
CHEMBL29067 107232 39 None 1 2 Guinea pig 8.4 pIC50 = 8.4 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00018a012
129796 107232 39 None 1 2 Guinea pig 8.4 pIC50 = 8.4 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL29067 107232 39 None 1 2 Guinea pig 8.4 pIC50 = 8.4 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
44350391 18257 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL1180409 18257 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL125576 18257 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL128034 18257 0 None - 1 Guinea pig 8.4 pIC50 = 8.4 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
10452437 20932 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 381 2 0 5 4.2 Cc1nc2cnccc2n1-c1ccc(C2=Nc3ccccc3N(C)C(=O)C2)cc1 10.1021/jm00018a011
CHEMBL119847 20932 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 381 2 0 5 4.2 Cc1nc2cnccc2n1-c1ccc(C2=Nc3ccccc3N(C)C(=O)C2)cc1 10.1021/jm00018a011
129796 107232 39 None -1 2 Human 8.3 pIC50 = 8.3 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
CHEMBL29067 107232 39 None -1 2 Human 8.3 pIC50 = 8.3 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
1859 7223 62 None 1 2 Human 7.4 pIC50 = 7.4 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00105a069
1860 7223 62 None 1 2 Human 7.4 pIC50 = 7.4 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00105a069
65889 7223 62 None 1 2 Human 7.4 pIC50 = 7.4 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00105a069
CHEMBL280164 7223 62 None 1 2 Human 7.4 pIC50 = 7.4 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00105a069
15123178 19007 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 603 25 0 5 8.9 CCCCCCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL1184468 19007 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 603 25 0 5 8.9 CCCCCCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL350819 19007 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 603 25 0 5 8.9 CCCCCCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
9889404 11028 1 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 439 7 1 5 3.5 Cc1ncccc1C(C#N)N1CCN(C(=O)CNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL100493 11028 1 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 439 7 1 5 3.5 Cc1ncccc1C(C#N)N1CCN(C(=O)CNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
3075901 209668 4 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 602 13 0 10 3.7 CCC(CC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL6270 209668 4 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 602 13 0 10 3.7 CCC(CC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
11743095 20518 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 424 8 0 7 2.4 COc1cc(CCC(=O)N2CCN(C(C#N)c3cccnc3)CC2)cc(OC)c1OC 10.1021/jm00100a018
CHEMBL1195221 20518 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 424 8 0 7 2.4 COc1cc(CCC(=O)N2CCN(C(C#N)c3cccnc3)CC2)cc(OC)c1OC 10.1021/jm00100a018
CHEMBL3215746 20518 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 424 8 0 7 2.4 COc1cc(CCC(=O)N2CCN(C(C#N)c3cccnc3)CC2)cc(OC)c1OC 10.1021/jm00100a018
10002744 11474 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 429 7 1 4 3.8 Cc1ncccc1C(CO)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL103465 11474 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 429 7 1 4 3.8 Cc1ncccc1C(CO)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
14992345 185650 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 601 25 0 9 5.5 CCCCCCCCCCOCCOCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2csc(C)c2)c1)OC 10.1021/jm00087a023
CHEMBL46972 185650 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 601 25 0 9 5.5 CCCCCCCCCCOCCOCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2csc(C)c2)c1)OC 10.1021/jm00087a023
14992367 184483 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 661 25 0 8 8.4 CCCCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)OC)c1 10.1021/jm00087a023
CHEMBL46421 184483 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 661 25 0 8 8.4 CCCCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)OC)c1 10.1021/jm00087a023
10370152 11518 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 543 10 0 5 5.9 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)N(Cc2ccccc2)Cc2ccccc2)CC1 10.1021/jm00072a019
CHEMBL103761 11518 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 543 10 0 5 5.9 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)N(Cc2ccccc2)Cc2ccccc2)CC1 10.1021/jm00072a019
3025824 170075 14 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 421 6 1 6 2.6 COC(=O)NC(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccccc1 10.1021/jm00072a019
CHEMBL418792 170075 14 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 421 6 1 6 2.6 COC(=O)NC(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccccc1 10.1021/jm00072a019
19829203 18478 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 598 24 1 7 7.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1scc[n+]1C)C(C)=O)OC 10.1021/jm00121a012
CHEMBL1181242 18478 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 598 24 1 7 7.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1scc[n+]1C)C(C)=O)OC 10.1021/jm00121a012
CHEMBL160529 18478 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 598 24 1 7 7.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1scc[n+]1C)C(C)=O)OC 10.1021/jm00121a012
14885641 121866 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 317 0 0 1 4.2 CC(=O)N1CCC(=C2c3ccccc3CCc3ccccc32)CC1 10.1021/jm00105a069
CHEMBL334318 121866 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 317 0 0 1 4.2 CC(=O)N1CCC(=C2c3ccccc3CCc3ccccc32)CC1 10.1021/jm00105a069
14992497 108287 0 None - 1 Guinea pig 4.4 pIC50 = 4.4 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 459 6 0 5 5.6 CC(C)(C)c1cc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)cc(C(C)(C)C)c1 10.1021/jm00087a023
CHEMBL298011 108287 0 None - 1 Guinea pig 4.4 pIC50 = 4.4 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 459 6 0 5 5.6 CC(C)(C)c1cc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)cc(C(C)(C)C)c1 10.1021/jm00087a023
15045517 11689 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 531 6 2 8 5.2 COC(=O)C1=C(c2ccc(-n3ccnc3)cc2)NC(C)=C(C(=O)Nc2nccs2)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
CHEMBL104620 11689 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 531 6 2 8 5.2 COC(=O)C1=C(c2ccc(-n3ccnc3)cc2)NC(C)=C(C(=O)Nc2nccs2)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
6324617 196342 27 None -2 2 Guinea pig 6.4 pIC50 = 6.4 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 424 0 3 10 -1.4 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6O)O[C@@]4(C(=O)O5)[C@@]12O 10.1016/0960-894X(95)00174-R
CHEMBL514432 196342 27 None -2 2 Guinea pig 6.4 pIC50 = 6.4 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 424 0 3 10 -1.4 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6O)O[C@@]4(C(=O)O5)[C@@]12O 10.1016/0960-894X(95)00174-R
6324617 196342 27 None -2 2 Guinea pig 6.4 pIC50 = 6.4 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 424 0 3 10 -1.4 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6O)O[C@@]4(C(=O)O5)[C@@]12O 10.1016/0960-894X(95)00173-Q
CHEMBL514432 196342 27 None -2 2 Guinea pig 6.4 pIC50 = 6.4 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 424 0 3 10 -1.4 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6O)O[C@@]4(C(=O)O5)[C@@]12O 10.1016/0960-894X(95)00173-Q
10433384 11436 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 440 7 0 5 3.9 Cc1ncccc1C(C#N)N1CCN(C(=O)COC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL103180 11436 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 440 7 0 5 3.9 Cc1ncccc1C(C#N)N1CCN(C(=O)COC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
3075911 209816 3 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 574 12 0 10 3.0 CCCC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL6341 209816 3 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 574 12 0 10 3.0 CCCC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
3075903 209567 7 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 546 10 0 10 2.3 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(C)=O)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL6217 209567 7 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 546 10 0 10 2.3 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(C)=O)C2)cc(OC)c1OC 10.1021/jm00060a006
14992313 107235 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 589 21 0 7 8.1 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1OC 10.1021/jm00087a023
CHEMBL290693 107235 0 None - 1 Guinea pig 5.4 pIC50 = 5.4 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 589 21 0 7 8.1 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1OC 10.1021/jm00087a023
9985928 18996 0 None - 1 Guinea pig 4.4 pIC50 = 4.4 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 467 18 0 2 7.1 CCCCCCCCCCCCCCOc1ccccc1CN(Cc1cccc[n+]1C)C(C)=O 10.1021/jm00057a008
CHEMBL1184398 18996 0 None - 1 Guinea pig 4.4 pIC50 = 4.4 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 467 18 0 2 7.1 CCCCCCCCCCCCCCOc1ccccc1CN(Cc1cccc[n+]1C)C(C)=O 10.1021/jm00057a008
CHEMBL347593 18996 0 None - 1 Guinea pig 4.4 pIC50 = 4.4 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 467 18 0 2 7.1 CCCCCCCCCCCCCCOc1ccccc1CN(Cc1cccc[n+]1C)C(C)=O 10.1021/jm00057a008
10405802 18185 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 353 3 0 6 4.4 Cc1nc2cnccc2n1-c1ccc(-c2nnc(-c3ccccc3)o2)cc1 10.1021/jm00018a011
CHEMBL118017 18185 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 353 3 0 6 4.4 Cc1nc2cnccc2n1-c1ccc(-c2nnc(-c3ccccc3)o2)cc1 10.1021/jm00018a011
10254227 11497 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 472 7 0 5 3.6 Cc1ncccc1C(C#N)N1CCN(C(=O)C[S+]([O-])C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL103584 11497 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 472 7 0 5 3.6 Cc1ncccc1C(C#N)N1CCN(C(=O)C[S+]([O-])C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
9978047 20244 0 None - 1 Guinea pig 4.4 pIC50 = 4.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 396 6 0 7 2.1 COc1cc(C(=O)N2CCN(C(C#N)c3ccccn3)CC2)cc(OC)c1OC 10.1021/jm00100a018
CHEMBL1193234 20244 0 None - 1 Guinea pig 4.4 pIC50 = 4.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 396 6 0 7 2.1 COc1cc(C(=O)N2CCN(C(C#N)c3ccccn3)CC2)cc(OC)c1OC 10.1021/jm00100a018
CHEMBL544606 20244 0 None - 1 Guinea pig 4.4 pIC50 = 4.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 396 6 0 7 2.1 COc1cc(C(=O)N2CCN(C(C#N)c3ccccn3)CC2)cc(OC)c1OC 10.1021/jm00100a018
10430314 29390 0 None - 1 Guinea pig 4.4 pIC50 = 4.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 387 5 0 3 3.6 O=C(C(c1ccccc1)c1ccccc1)N1CC[N+]([O-])(Cc2cccnc2)CC1 10.1021/jm00100a018
CHEMBL132665 29390 0 None - 1 Guinea pig 4.4 pIC50 = 4.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 387 5 0 3 3.6 O=C(C(c1ccccc1)c1ccccc1)N1CC[N+]([O-])(Cc2cccnc2)CC1 10.1021/jm00100a018
9977185 120061 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 382 2 0 6 3.6 Cc1nc2cnccc2n1-c1ccc(C2=Nc3ncccc3N(C)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL331512 120061 0 None - 1 Guinea pig 7.4 pIC50 = 7.4 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 382 2 0 6 3.6 Cc1nc2cnccc2n1-c1ccc(C2=Nc3ncccc3N(C)C(=O)C2)cc1 10.1021/jm00018a012
10428543 20771 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 359 4 1 4 2.5 N#CC(c1cccnc1)N1CCN(C(=O)Cc2c[nH]c3ccccc23)CC1 10.1021/jm00100a018
CHEMBL1197021 20771 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 359 4 1 4 2.5 N#CC(c1cccnc1)N1CCN(C(=O)Cc2c[nH]c3ccccc23)CC1 10.1021/jm00100a018
CHEMBL559013 20771 0 None - 1 Guinea pig 6.4 pIC50 = 6.4 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 359 4 1 4 2.5 N#CC(c1cccnc1)N1CCN(C(=O)Cc2c[nH]c3ccccc23)CC1 10.1021/jm00100a018
3075898 92300 3 None - 1 Guinea pig 4.4 pIC50 = 4.4 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 770 26 0 10 8.5 CCCCCCCCCCCCCCCCCC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL227457 92300 3 None - 1 Guinea pig 4.4 pIC50 = 4.4 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 770 26 0 10 8.5 CCCCCCCCCCCCCCCCCC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
10345734 11486 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 496 8 0 6 4.0 CCOC(=O)C(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)(c1ccccc1)c1ccccc1 10.1021/jm00072a019
CHEMBL103533 11486 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 496 8 0 6 4.0 CCOC(=O)C(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)(c1ccccc1)c1ccccc1 10.1021/jm00072a019
10431694 30346 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 410 7 0 7 2.1 COc1cc(CC(=O)N2CCN(C(C#N)c3cccnc3)CC2)cc(OC)c1OC 10.1021/jm00100a018
CHEMBL133425 30346 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 410 7 0 7 2.1 COc1cc(CC(=O)N2CCN(C(C#N)c3cccnc3)CC2)cc(OC)c1OC 10.1021/jm00100a018
14992457 185387 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 601 18 0 6 8.9 CCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(C(C)(C)C)c1 10.1021/jm00087a023
CHEMBL46735 185387 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 601 18 0 6 8.9 CCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(C(C)(C)C)c1 10.1021/jm00087a023
10341289 171070 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 406 6 2 5 1.9 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(N)=O)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL421204 171070 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 406 6 2 5 1.9 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(N)=O)c2ccccc2)CC1 10.1021/jm00072a019
3075910 82185 7 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 617 13 1 10 3.5 CCC(C)CNC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL204022 82185 7 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 617 13 1 10 3.5 CCC(C)CNC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
14785969 18260 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 559 22 0 4 8.5 CCCCCCCCCCCCCCCCCCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL1180419 18260 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 559 22 0 4 8.5 CCCCCCCCCCCCCCCCCCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL125903 18260 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 559 22 0 4 8.5 CCCCCCCCCCCCCCCCCCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
14992361 178566 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 647 23 0 8 8.0 CCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)OC)c1C 10.1021/jm00087a023
CHEMBL44679 178566 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 647 23 0 8 8.0 CCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)OC)c1C 10.1021/jm00087a023
9972438 19694 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 306 3 0 4 2.1 N#CC(c1cccnc1)N1CCN(C(=O)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL1189101 19694 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 306 3 0 4 2.1 N#CC(c1cccnc1)N1CCN(C(=O)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL3215984 19694 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 306 3 0 4 2.1 N#CC(c1cccnc1)N1CCN(C(=O)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL320241 115340 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 586 10 2 9 5.8 CCO/C(O)=C1\C(COCCn2c(C)nc3ccncc32)=NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
14785928 18941 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 540 25 0 6 7.4 CCCCCCCCCCCCCCCCOCC1OCC(COC(=O)CCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL1184203 18941 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 540 25 0 6 7.4 CCCCCCCCCCCCCCCCOCC1OCC(COC(=O)CCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL338850 18941 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 540 25 0 6 7.4 CCCCCCCCCCCCCCCCOCC1OCC(COC(=O)CCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
10338957 121320 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 367 2 1 5 4.2 Cc1nc2cnccc2n1-c1ccc(C2=Nc3ccccc3NC(=O)C2)cc1 10.1021/jm00018a011
CHEMBL333674 121320 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 367 2 1 5 4.2 Cc1nc2cnccc2n1-c1ccc(C2=Nc3ccccc3NC(=O)C2)cc1 10.1021/jm00018a011
9978272 174888 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 399 2 0 7 3.3 Cc1nn(C)c2c1N(C)C(=O)CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a012
CHEMBL432832 174888 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 399 2 0 7 3.3 Cc1nn(C)c2c1N(C)C(=O)CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a012
15005345 115548 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 609 7 2 8 7.0 CCOC(=O)C1=C(c2ccc(-c3c(C)nc4sccn34)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL320900 115548 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 609 7 2 8 7.0 CCOC(=O)C1=C(c2ccc(-c3c(C)nc4sccn34)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
10457056 120579 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 462 3 0 8 4.0 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(-c4ccncc4)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
CHEMBL332448 120579 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 462 3 0 8 4.0 Cc1nc2cnccc2n1-c1ccc(C2=Nc3c(-c4ccncc4)nn(C)c3N(C)C(=O)C2)cc1 10.1021/jm00018a012
9981039 120581 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 446 2 1 6 4.3 Cc1nc2cnccc2n1-c1ccc(C2=Nc3ncc(Br)cc3NC(=O)C2)cc1 10.1021/jm00018a012
CHEMBL332455 120581 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 446 2 1 6 4.3 Cc1nc2cnccc2n1-c1ccc(C2=Nc3ncc(Br)cc3NC(=O)C2)cc1 10.1021/jm00018a012
15005364 116652 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 527 6 2 7 4.8 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(N)=O)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL323407 116652 0 None - 1 Guinea pig 8.3 pIC50 = 8.3 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 527 6 2 7 4.8 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(N)=O)C1c1ccccc1Cl 10.1021/jm00095a005
15005361 116470 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 632 7 2 8 7.0 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4c(C)nc(C)cc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL322772 116470 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 632 7 2 8 7.0 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4c(C)nc(C)cc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
10365929 20383 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 439 8 1 5 3.4 N#CC(c1cccnc1)N1CCN(C(=O)CNC(Cc2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL1194240 20383 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 439 8 1 5 3.4 N#CC(c1cccnc1)N1CCN(C(=O)CNC(Cc2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL545773 20383 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 439 8 1 5 3.4 N#CC(c1cccnc1)N1CCN(C(=O)CNC(Cc2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
10094623 104952 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 437 5 1 5 3.5 Cc1ncccc1C(C#N)N1CCN(C(=O)CNC2c3ccccc3-c3ccccc32)CC1 10.1021/jm00072a019
CHEMBL273945 104952 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 437 5 1 5 3.5 Cc1ncccc1C(C#N)N1CCN(C(=O)CNC2c3ccccc3-c3ccccc32)CC1 10.1021/jm00072a019
9986982 103675 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 672 13 0 11 4.0 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)COc3ccc(Cl)cc3)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL265773 103675 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 672 13 0 11 4.0 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)COc3ccc(Cl)cc3)C2)cc(OC)c1OC 10.1021/jm00060a006
10092997 20601 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 410 6 0 4 4.0 N#CC(c1ccncc1)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL1195793 20601 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 410 6 0 4 4.0 N#CC(c1ccncc1)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL3216867 20601 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 410 6 0 4 4.0 N#CC(c1ccncc1)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
15123190 18497 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 541 17 0 6 5.1 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCCCCCOCCCc2ccccc2)C1 10.1021/jm00082a007
CHEMBL1181289 18497 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 541 17 0 6 5.1 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCCCCCOCCCc2ccccc2)C1 10.1021/jm00082a007
CHEMBL162251 18497 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 541 17 0 6 5.1 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCCCCCOCCCc2ccccc2)C1 10.1021/jm00082a007
14992505 170230 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 617 22 0 7 8.7 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(CC)c3)c2)c1OC 10.1021/jm00087a023
CHEMBL41988 170230 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 617 22 0 7 8.7 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(CC)c3)c2)c1OC 10.1021/jm00087a023
15719134 185898 0 None - 1 Guinea pig 4.3 pIC50 = 4.3 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 531 18 0 6 7.3 CCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1 10.1021/jm00087a023
CHEMBL47192 185898 0 None - 1 Guinea pig 4.3 pIC50 = 4.3 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 531 18 0 6 7.3 CCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1 10.1021/jm00087a023
44268223 17901 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 563 22 0 5 7.9 CCCCCCCCCCCCCCCCOC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
CHEMBL1178072 17901 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 563 22 0 5 7.9 CCCCCCCCCCCCCCCCOC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
CHEMBL12499 17901 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 563 22 0 5 7.9 CCCCCCCCCCCCCCCCOC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
14785976 18246 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 589 24 0 5 8.2 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL1180391 18246 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 589 24 0 5 8.2 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL124985 18246 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 589 24 0 5 8.2 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
10404661 20136 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 334 5 0 4 2.4 N#CC(c1cccnc1)N1CCN(C(=O)CCc2ccccc2)CC1 10.1021/jm00100a018
CHEMBL1192430 20136 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 334 5 0 4 2.4 N#CC(c1cccnc1)N1CCN(C(=O)CCc2ccccc2)CC1 10.1021/jm00100a018
CHEMBL3215980 20136 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 334 5 0 4 2.4 N#CC(c1cccnc1)N1CCN(C(=O)CCc2ccccc2)CC1 10.1021/jm00100a018
10045642 28340 2 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 385 6 0 3 3.9 O=C(CC(c1ccccc1)c1ccccc1)N1CCN(Cc2cccnc2)CC1 10.1021/jm00100a018
CHEMBL131690 28340 2 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 385 6 0 3 3.9 O=C(CC(c1ccccc1)c1ccccc1)N1CCN(Cc2cccnc2)CC1 10.1021/jm00100a018
1114860 19918 11 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 385 5 0 6 1.7 COc1cc(C(=O)N2CCN(C(=O)c3cccnc3)CC2)cc(OC)c1OC 10.1021/jm00100a018
CHEMBL1190656 19918 11 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 385 5 0 6 1.7 COc1cc(C(=O)N2CCN(C(=O)c3cccnc3)CC2)cc(OC)c1OC 10.1021/jm00100a018
CHEMBL541330 19918 11 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 385 5 0 6 1.7 COc1cc(C(=O)N2CCN(C(=O)c3cccnc3)CC2)cc(OC)c1OC 10.1021/jm00100a018
10085405 31044 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 286 2 0 4 1.8 CC(C)(C)C(=O)N1CCN(C(C#N)c2cccnc2)CC1 10.1021/jm00100a018
CHEMBL134025 31044 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 286 2 0 4 1.8 CC(C)(C)C(=O)N1CCN(C(C#N)c2cccnc2)CC1 10.1021/jm00100a018
14992357 185227 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 675 27 0 8 8.9 CCCCCCCCCCCCCCCCOc1ccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)OC)cc1 10.1021/jm00087a023
CHEMBL46616 185227 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 675 27 0 8 8.9 CCCCCCCCCCCCCCCCOc1ccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)OC)cc1 10.1021/jm00087a023
10365930 11529 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 439 8 1 5 3.6 N#CC(c1cccnc1)N1CCN(C(=O)CCNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL103801 11529 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 439 8 1 5 3.6 N#CC(c1cccnc1)N1CCN(C(=O)CCNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
10365930 11529 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 439 8 1 5 3.6 N#CC(c1cccnc1)N1CCN(C(=O)CCNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL103801 11529 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 439 8 1 5 3.6 N#CC(c1cccnc1)N1CCN(C(=O)CCNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
10452217 29609 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 377 8 1 5 2.0 N#CC(c1cccnc1)N1CCN(C(=O)CNCCCc2ccccc2)CC1 10.1021/jm00100a018
CHEMBL1203313 29609 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 377 8 1 5 2.0 N#CC(c1cccnc1)N1CCN(C(=O)CNCCCc2ccccc2)CC1 10.1021/jm00100a018
CHEMBL132835 29609 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 377 8 1 5 2.0 N#CC(c1cccnc1)N1CCN(C(=O)CNCCCc2ccccc2)CC1 10.1021/jm00100a018
14992385 177633 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 639 27 0 7 8.7 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2ccsc2CC(C)C)c1)OC 10.1021/jm00087a023
CHEMBL44540 177633 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 639 27 0 7 8.7 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2ccsc2CC(C)C)c1)OC 10.1021/jm00087a023
14786005 18957 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 519 22 1 4 7.1 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)NCc2cccc[n+]2CC)C1 10.1021/jm00105a058
CHEMBL1184239 18957 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 519 22 1 4 7.1 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)NCc2cccc[n+]2CC)C1 10.1021/jm00105a058
CHEMBL340480 18957 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 519 22 1 4 7.1 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)NCc2cccc[n+]2CC)C1 10.1021/jm00105a058
132290 108133 13 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 631 21 0 8 8.2 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1C(=O)OC 10.1021/jm00087a023
CHEMBL296973 108133 13 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 631 21 0 8 8.2 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1C(=O)OC 10.1021/jm00087a023
132290 108133 13 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 631 21 0 8 8.2 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1C(=O)OC 10.1021/jm00057a008
CHEMBL296973 108133 13 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 631 21 0 8 8.2 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1C(=O)OC 10.1021/jm00057a008
14785889 18943 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 524 26 0 4 8.5 CCCCCCCCCCCCCCCCOCC1COC(COCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL1184207 18943 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 524 26 0 4 8.5 CCCCCCCCCCCCCCCCOCC1COC(COCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL338977 18943 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 524 26 0 4 8.5 CCCCCCCCCCCCCCCCOCC1COC(COCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
44372276 18440 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 612 25 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+]1(C)CCCCC1)C(C)=O)OC 10.1021/jm00121a012
CHEMBL1181119 18440 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 612 25 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+]1(C)CCCCC1)C(C)=O)OC 10.1021/jm00121a012
CHEMBL156397 18440 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 612 25 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+]1(C)CCCCC1)C(C)=O)OC 10.1021/jm00121a012
14992495 185912 0 None - 1 Guinea pig 4.3 pIC50 = 4.3 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 467 9 0 6 4.9 Cc1c[n+](Cc2cccc(OP(=O)([O-])Oc3ccc(OCc4ccccc4)cc3)c2)cs1 10.1021/jm00087a023
CHEMBL47199 185912 0 None - 1 Guinea pig 4.3 pIC50 = 4.3 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 467 9 0 6 4.9 Cc1c[n+](Cc2cccc(OP(=O)([O-])Oc3ccc(OCc4ccccc4)cc3)c2)cs1 10.1021/jm00087a023
10026204 30394 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 439 8 1 5 3.6 N#CC(c1ccncc1)N1CCN(C(=O)CCNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL133457 30394 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 439 8 1 5 3.6 N#CC(c1ccncc1)N1CCN(C(=O)CCNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
44344958 120595 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 435 2 1 8 4.3 Cc1cc2c(cc1C)-n1c(O)nnc1CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a012
CHEMBL332542 120595 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 435 2 1 8 4.3 Cc1cc2c(cc1C)-n1c(O)nnc1CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a012
10409530 11079 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 414 4 0 4 3.7 Cc1ncccc1C(C#N)N1CCN(C(=O)/C=C(\c2ccccc2)C(F)(F)F)CC1 10.1021/jm00072a019
CHEMBL100839 11079 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 414 4 0 4 3.7 Cc1ncccc1C(C#N)N1CCN(C(=O)/C=C(\c2ccccc2)C(F)(F)F)CC1 10.1021/jm00072a019
107757 8005 3 None -4 2 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1016/0960-894X(95)00174-R
1852 8005 3 None -4 2 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1016/0960-894X(95)00174-R
CHEMBL1180101 8005 3 None -4 2 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1016/0960-894X(95)00174-R
107757 8005 3 None -4 2 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1016/0960-894X(95)00173-Q
1852 8005 3 None -4 2 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1016/0960-894X(95)00173-Q
CHEMBL1180101 8005 3 None -4 2 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1016/0960-894X(95)00173-Q
11744660 20445 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 453 9 1 5 3.6 N#CC(c1cccnc1)N1CCN(CCNC(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL1194682 20445 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 453 9 1 5 3.6 N#CC(c1cccnc1)N1CCN(CCNC(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL553093 20445 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 453 9 1 5 3.6 N#CC(c1cccnc1)N1CCN(CCNC(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
14785922 18252 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 552 26 0 5 8.9 CCCCCCCCCCCCCCCCCCCC1OCC(COC(=O)CCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL1180402 18252 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 552 26 0 5 8.9 CCCCCCCCCCCCCCCCCCCC1OCC(COC(=O)CCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL125418 18252 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 552 26 0 5 8.9 CCCCCCCCCCCCCCCCCCCC1OCC(COC(=O)CCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
10327687 17899 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 616 24 1 5 8.5 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1016/0960-894X(95)00174-R
CHEMBL1178067 17899 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 616 24 1 5 8.5 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1016/0960-894X(95)00174-R
CHEMBL12438 17899 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 616 24 1 5 8.5 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1016/0960-894X(95)00174-R
11754151 11361 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 463 6 1 6 3.8 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)OC(C)(C)C)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL102666 11361 0 None - 1 Guinea pig 7.3 pIC50 = 7.3 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 463 6 1 6 3.8 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)OC(C)(C)C)c2ccccc2)CC1 10.1021/jm00072a019
14992465 108164 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 641 20 0 6 9.7 CCCCCCCCCCCCCCOc1cc(Cl)c(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)cc1Cl 10.1021/jm00087a023
CHEMBL297182 108164 0 None - 1 Guinea pig 6.3 pIC50 = 6.3 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 641 20 0 6 9.7 CCCCCCCCCCCCCCOc1cc(Cl)c(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)cc1Cl 10.1021/jm00087a023
44372210 18486 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 586 26 1 6 7.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+](C)(C)C)C(=O)CC)OC 10.1021/jm00121a012
CHEMBL1181261 18486 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 586 26 1 6 7.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+](C)(C)C)C(=O)CC)OC 10.1021/jm00121a012
CHEMBL160910 18486 0 None - 1 Guinea pig 5.3 pIC50 = 5.3 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 586 26 1 6 7.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+](C)(C)C)C(=O)CC)OC 10.1021/jm00121a012
44268181 17898 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 634 24 1 6 8.3 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
CHEMBL1178062 17898 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 634 24 1 6 8.3 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
CHEMBL12399 17898 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 634 24 1 6 8.3 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
9987603 17902 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL1178073 17902 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL12554 17902 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
44268128 17907 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 547 22 0 5 7.1 CCCCCCCCCCCCCCCCOC[C@@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL1178084 17907 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 547 22 0 5 7.1 CCCCCCCCCCCCCCCCOC[C@@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL12836 17907 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 547 22 0 5 7.1 CCCCCCCCCCCCCCCCOC[C@@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
44267830 17893 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 655 27 1 5 10.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2cccc3ccccc32)CSC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178052 17893 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 655 27 1 5 10.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2cccc3ccccc32)CSC1 10.1016/0960-894X(95)00173-Q
CHEMBL12125 17893 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 655 27 1 5 10.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2cccc3ccccc32)CSC1 10.1016/0960-894X(95)00173-Q
14992439 179439 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 681 21 0 7 9.2 CCCCCCCCCCCCCCOc1cc(Br)cc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1OC 10.1021/jm00087a023
CHEMBL44975 179439 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 681 21 0 7 9.2 CCCCCCCCCCCCCCOc1cc(Br)cc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1OC 10.1021/jm00087a023
10049993 32158 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 462 6 0 4 5.1 Cn1cc(C(C#N)N2CCN(C(=O)CC(c3ccccc3)c3ccccc3)CC2)c2ccccc21 10.1021/jm00100a018
CHEMBL134965 32158 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 462 6 0 4 5.1 Cn1cc(C(C#N)N2CCN(C(=O)CC(c3ccccc3)c3ccccc3)CC2)c2ccccc21 10.1021/jm00100a018
21463423 19197 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 630 24 1 5 9.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL1185897 19197 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 630 24 1 5 9.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL440088 19197 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 630 24 1 5 9.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCC1 10.1016/0960-894X(95)00173-Q
14992308 179362 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 631 24 0 7 8.3 CCCCCCCCCCCCCCc1cccc(OCC(COP(=O)([O-])Oc2ccccc2C[n+]2ccsc2)OC)c1 10.1021/jm00087a023
CHEMBL44887 179362 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 631 24 0 7 8.3 CCCCCCCCCCCCCCc1cccc(OCC(COP(=O)([O-])Oc2ccccc2C[n+]2ccsc2)OC)c1 10.1021/jm00087a023
15005337 12060 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 553 7 2 7 5.8 CCOC(=O)C1=C(c2ccc(-n3cnc(C)c3)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
CHEMBL106564 12060 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
ChEMBL 553 7 2 7 5.8 CCOC(=O)C1=C(c2ccc(-n3cnc(C)c3)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00095a005
44372258 19006 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 601 25 1 6 6.8 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+](C)(C)C)C(=O)N(C)C)OC 10.1021/jm00121a012
CHEMBL1184461 19006 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 601 25 1 6 6.8 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+](C)(C)C)C(=O)N(C)C)OC 10.1021/jm00121a012
CHEMBL350437 19006 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 601 25 1 6 6.8 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+](C)(C)C)C(=O)N(C)C)OC 10.1021/jm00121a012
14992319 169769 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 583 25 0 7 7.5 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1ccccc1C[n+]1ccsc1)OC 10.1021/jm00087a023
CHEMBL417532 169769 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 583 25 0 7 7.5 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1ccccc1C[n+]1ccsc1)OC 10.1021/jm00087a023
10073576 18664 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 473 7 0 9 3.1 COCCOCc1nn(C)c2c1N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)CC(=O)N2C 10.1021/jm00018a012
CHEMBL118247 18664 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 473 7 0 9 3.1 COCCOCc1nn(C)c2c1N=C(c1ccc(-n3c(C)nc4cnccc43)cc1)CC(=O)N2C 10.1021/jm00018a012
CHEMBL322029 116240 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 586 10 2 9 5.8 CCO/C(O)=C1\C(COCCn2c(C)nc3ncccc32)=NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
10092142 120096 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 396 2 1 6 4.2 Cc1cc(C)c2c(n1)NC(=O)CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a012
CHEMBL331567 120096 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 396 2 1 6 4.2 Cc1cc(C)c2c(n1)NC(=O)CC(c1ccc(-n3c(C)nc4cnccc43)cc1)=N2 10.1021/jm00018a012
14785956 18261 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL1180425 18261 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL126016 18261 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL419779 18261 0 None - 1 Guinea pig 8.2 pIC50 = 8.2 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
10048849 20289 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 439 7 0 5 3.5 CN(CC(=O)N1CCN(C(C#N)c2cccnc2)CC1)C(c1ccccc1)c1ccccc1 10.1021/jm00100a018
CHEMBL1193630 20289 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 439 7 0 5 3.5 CN(CC(=O)N1CCN(C(C#N)c2cccnc2)CC1)C(c1ccccc1)c1ccccc1 10.1021/jm00100a018
CHEMBL545072 20289 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 439 7 0 5 3.5 CN(CC(=O)N1CCN(C(C#N)c2cccnc2)CC1)C(c1ccccc1)c1ccccc1 10.1021/jm00100a018
3075901 209668 4 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 602 13 0 10 3.7 CCC(CC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL6270 209668 4 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 602 13 0 10 3.7 CCC(CC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL432393 174840 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 564 9 2 7 6.2 CCO/C(O)=C1\C(COCCn2c(C)nc3ccccc32)=NC(C)=C(C(=O)NC(C)(C)C)[C@@H]1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
15005363 121209 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 323 5 0 6 2.9 CCOC(=O)CC(=O)c1ccc(-n2c(C)nc3cnccc32)cc1 10.1021/jm00018a011
CHEMBL333242 121209 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 323 5 0 6 2.9 CCOC(=O)CC(=O)c1ccc(-n2c(C)nc3cnccc32)cc1 10.1021/jm00018a011
14785908 18287 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 482 23 0 4 7.8 CCCCCCCCCCCCCCCCCC1OCC(COCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL1180479 18287 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 482 23 0 4 7.8 CCCCCCCCCCCCCCCCCC1OCC(COCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
CHEMBL127446 18287 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 482 23 0 4 7.8 CCCCCCCCCCCCCCCCCC1OCC(COCCCC[n+]2ccsc2)O1 10.1021/jm00105a058
14786031 18293 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 463 22 0 3 8.0 CCCCCCCCCCCCCCC1COC(COCCCCCC[N+]2(C)C=CN=C2)C1 10.1021/jm00105a058
CHEMBL1180488 18293 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 463 22 0 3 8.0 CCCCCCCCCCCCCCC1COC(COCCCCCC[N+]2(C)C=CN=C2)C1 10.1021/jm00105a058
CHEMBL127799 18293 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 463 22 0 3 8.0 CCCCCCCCCCCCCCC1COC(COCCCCCC[N+]2(C)C=CN=C2)C1 10.1021/jm00105a058
9985407 18432 0 None - 1 Guinea pig 4.2 pIC50 = 4.2 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 439 17 1 2 6.5 CCCCCCCCCCCCCCOc1ccc(CNC(=O)c2cc[n+](C)cc2)cc1 10.1021/jm00057a008
CHEMBL1181097 18432 0 None - 1 Guinea pig 4.2 pIC50 = 4.2 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 439 17 1 2 6.5 CCCCCCCCCCCCCCOc1ccc(CNC(=O)c2cc[n+](C)cc2)cc1 10.1021/jm00057a008
CHEMBL155500 18432 0 None - 1 Guinea pig 4.2 pIC50 = 4.2 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 439 17 1 2 6.5 CCCCCCCCCCCCCCOc1ccc(CNC(=O)c2cc[n+](C)cc2)cc1 10.1021/jm00057a008
44268194 18731 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 634 24 1 6 8.3 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
CHEMBL1182938 18731 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 634 24 1 6 8.3 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
CHEMBL273445 18731 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 634 24 1 6 8.3 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
1853 10324 38 None -6 2 Human 6.2 pIC50 = 6.2 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 352 0 0 2 4.3 Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 10.1021/jm00105a069
60680 10324 38 None -6 2 Human 6.2 pIC50 = 6.2 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 352 0 0 2 4.3 Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 10.1021/jm00105a069
CHEMBL10971 10324 38 None -6 2 Human 6.2 pIC50 = 6.2 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 352 0 0 2 4.3 Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 10.1021/jm00105a069
14992325 108099 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 654 27 1 8 8.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)([O-])Oc1ccccc1C[n+]1ccsc1)OC 10.1021/jm00087a023
CHEMBL296668 108099 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 654 27 1 8 8.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)([O-])Oc1ccccc1C[n+]1ccsc1)OC 10.1021/jm00087a023
14992483 185852 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 643 23 0 7 9.4 CCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(C(=O)CCCCC)c1 10.1021/jm00087a023
CHEMBL47158 185852 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 643 23 0 7 9.4 CCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(C(=O)CCCCC)c1 10.1021/jm00087a023
14992405 107291 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 559 20 0 6 8.1 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1 10.1021/jm00087a023
CHEMBL291177 107291 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 559 20 0 6 8.1 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1 10.1021/jm00087a023
10252309 114206 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 433 6 0 6 2.7 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)N2CCOC2=O)CC1 10.1021/jm00072a019
CHEMBL318163 114206 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 433 6 0 6 2.7 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(c2ccccc2)N2CCOC2=O)CC1 10.1021/jm00072a019
10318595 20041 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 396 7 0 4 4.5 N#CC(c1cccnc1)N1CCN(CCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL1191610 20041 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 396 7 0 4 4.5 N#CC(c1cccnc1)N1CCN(CCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL542731 20041 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 396 7 0 4 4.5 N#CC(c1cccnc1)N1CCN(CCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
14992403 179514 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 587 22 0 6 8.9 CCCCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2ccccc2C[n+]2ccsc2)c1 10.1021/jm00087a023
CHEMBL45073 179514 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 587 22 0 6 8.9 CCCCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2ccccc2C[n+]2ccsc2)c1 10.1021/jm00087a023
10072971 11109 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 460 6 1 5 3.0 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)N2CCCC2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL100971 11109 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 460 6 1 5 3.0 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)N2CCCC2)c2ccccc2)CC1 10.1021/jm00072a019
10100641 18449 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 511 18 0 4 6.8 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2C)C(C)=O)cc1OC 10.1021/jm00057a008
CHEMBL1181153 18449 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 511 18 0 4 6.8 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2C)C(C)=O)cc1OC 10.1021/jm00057a008
CHEMBL157123 18449 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 511 18 0 4 6.8 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2C)C(C)=O)cc1OC 10.1021/jm00057a008
14992441 106990 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 603 21 0 7 8.4 CCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(OC)c1 10.1021/jm00087a023
CHEMBL288399 106990 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 603 21 0 7 8.4 CCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(OC)c1 10.1021/jm00087a023
14992347 185603 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 607 25 0 7 7.8 CCCCC/C=C/C/C=C/CCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2ccsc2)c1)OC 10.1021/jm00087a023
CHEMBL46928 185603 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 607 25 0 7 7.8 CCCCC/C=C/C/C=C/CCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2ccsc2)c1)OC 10.1021/jm00087a023
14992333 179329 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 631 24 0 7 8.3 CCCCCCCCCCCCCCc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)OC)c1 10.1021/jm00087a023
CHEMBL44846 179329 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 631 24 0 7 8.3 CCCCCCCCCCCCCCc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)OC)c1 10.1021/jm00087a023
15719162 108195 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 657 18 0 6 10.2 CCCCCCCCCCCCOc1cc(C(C)(C)C)c(OP(=O)([O-])Oc2ccccc2C[n+]2csc(C)c2)cc1C(C)(C)C 10.1021/jm00087a023
CHEMBL297375 108195 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 657 18 0 6 10.2 CCCCCCCCCCCCOc1cc(C(C)(C)C)c(OP(=O)([O-])Oc2ccccc2C[n+]2csc(C)c2)cc1C(C)(C)C 10.1021/jm00087a023
44267834 17855 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 584 25 0 4 9.5 CCCCCCCCCCCCCCCCOCC1(COC(=O)CCCCC[n+]2cccc3ccccc32)CSC1 10.1016/0960-894X(95)00173-Q
CHEMBL1177954 17855 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 584 25 0 4 9.5 CCCCCCCCCCCCCCCCOCC1(COC(=O)CCCCC[n+]2cccc3ccccc32)CSC1 10.1016/0960-894X(95)00173-Q
CHEMBL8529 17855 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 584 25 0 4 9.5 CCCCCCCCCCCCCCCCOCC1(COC(=O)CCCCC[n+]2cccc3ccccc32)CSC1 10.1016/0960-894X(95)00173-Q
10384391 18562 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 368 2 1 6 3.6 Cc1nc2cnccc2n1-c1ccc(C2=Nc3ncccc3NC(=O)C2)cc1 10.1021/jm00018a012
CHEMBL118182 18562 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 368 2 1 6 3.6 Cc1nc2cnccc2n1-c1ccc(C2=Nc3ncccc3NC(=O)C2)cc1 10.1021/jm00018a012
14992485 185582 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 599 20 0 6 8.8 CCCCCCCCCCCCCCc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(C(C)=O)c1 10.1021/jm00087a023
CHEMBL46907 185582 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 599 20 0 6 8.8 CCCCCCCCCCCCCCc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(C(C)=O)c1 10.1021/jm00087a023
14992381 185868 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 597 25 0 7 7.8 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2cscc2C)c1)OC 10.1021/jm00087a023
CHEMBL47167 185868 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 597 25 0 7 7.8 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2cscc2C)c1)OC 10.1021/jm00087a023
10427042 20448 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 335 1 0 3 3.3 Cc1nc2cnccc2n1-c1ccc(I)cc1 10.1021/jm00018a011
CHEMBL119470 20448 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 335 1 0 3 3.3 Cc1nc2cnccc2n1-c1ccc(I)cc1 10.1021/jm00018a011
14885628 126212 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 336 0 0 2 3.8 CC(=O)N1CCC(=C2c3ccc(F)cc3CCc3cccnc32)CC1 10.1021/jm00105a069
CHEMBL344942 126212 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 336 0 0 2 3.8 CC(=O)N1CCC(=C2c3ccc(F)cc3CCc3cccnc32)CC1 10.1021/jm00105a069
14992469 108126 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 617 21 0 8 7.9 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1C(=O)OC 10.1021/jm00087a023
CHEMBL296921 108126 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 617 21 0 8 7.9 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)c1C(=O)OC 10.1021/jm00087a023
44372057 18483 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 612 25 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC1CCC[N+]1(C)CC)C(C)=O)OC 10.1021/jm00121a012
CHEMBL1181251 18483 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 612 25 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC1CCC[N+]1(C)CC)C(C)=O)OC 10.1021/jm00121a012
CHEMBL160759 18483 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 612 25 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC1CCC[N+]1(C)CC)C(C)=O)OC 10.1021/jm00121a012
10255815 11435 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 511 8 0 6 4.5 COC(=O)N(Cc1ccccc1)C(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccccc1 10.1021/jm00072a019
CHEMBL103171 11435 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 511 8 0 6 4.5 COC(=O)N(Cc1ccccc1)C(CC(=O)N1CCN(C(C#N)c2cccnc2C)CC1)c1ccccc1 10.1021/jm00072a019
9981360 125112 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 453 7 1 5 2.7 N#CC(c1ccncc1)N1CCN(C(=O)CNC(=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL340989 125112 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 453 7 1 5 2.7 N#CC(c1ccncc1)N1CCN(C(=O)CNC(=O)C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
14992329 179450 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 597 25 0 7 7.8 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2csc(C)c2)c1)OC 10.1021/jm00087a023
CHEMBL44995 179450 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 597 25 0 7 7.8 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2csc(C)c2)c1)OC 10.1021/jm00087a023
10008846 18431 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 481 17 0 3 6.8 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2ccc[n+](C)c2)C(C)=O)cc1 10.1021/jm00057a008
CHEMBL1181092 18431 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 481 17 0 3 6.8 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2ccc[n+](C)c2)C(C)=O)cc1 10.1021/jm00057a008
CHEMBL155380 18431 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 481 17 0 3 6.8 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2ccc[n+](C)c2)C(C)=O)cc1 10.1021/jm00057a008
14992331 180331 0 None - 1 Guinea pig 4.2 pIC50 = 4.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 597 25 0 7 7.8 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1ccc(C[n+]2csc(C)c2)cc1)OC 10.1021/jm00087a023
CHEMBL45321 180331 0 None - 1 Guinea pig 4.2 pIC50 = 4.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 597 25 0 7 7.8 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1ccc(C[n+]2csc(C)c2)cc1)OC 10.1021/jm00087a023
44267841 17888 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 589 27 1 5 8.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccccc2)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178044 17888 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 589 27 1 5 8.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccccc2)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL11977 17888 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 589 27 1 5 8.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccccc2)COC1 10.1016/0960-894X(95)00173-Q
44268198 17906 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 698 24 1 7 8.9 CCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(=O)c2ccc(OC)cc2)S1 10.1016/0960-894X(95)00174-R
CHEMBL1178083 17906 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 698 24 1 7 8.9 CCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(=O)c2ccc(OC)cc2)S1 10.1016/0960-894X(95)00174-R
CHEMBL12773 17906 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 698 24 1 7 8.9 CCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(=O)c2ccc(OC)cc2)S1 10.1016/0960-894X(95)00174-R
15123169 18496 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 393 9 0 5 2.9 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCC(C)C)C1 10.1021/jm00082a007
CHEMBL1181280 18496 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 393 9 0 5 2.9 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCC(C)C)C1 10.1021/jm00082a007
CHEMBL161674 18496 0 None - 1 Guinea pig 6.2 pIC50 = 6.2 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 393 9 0 5 2.9 CC[n+]1ccccc1CN(C(C)=O)C(=O)OCC1COC(OCCC(C)C)C1 10.1021/jm00082a007
10077200 84903 0 None - 1 Guinea pig 4.2 pIC50 = 4.2 Functional
PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.
ChEMBL 593 31 0 6 8.3 CCCCCCCCC(CCCCCCCC)CCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)OC 10.1021/jm00007a018
CHEMBL21033 84903 0 None - 1 Guinea pig 4.2 pIC50 = 4.2 Functional
PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.
ChEMBL 593 31 0 6 8.3 CCCCCCCCC(CCCCCCCC)CCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)OC 10.1021/jm00007a018
14992343 108118 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 587 25 0 9 5.2 CCCCCCCCCCOCCOCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2ccsc2)c1)OC 10.1021/jm00087a023
CHEMBL296849 108118 0 None - 1 Guinea pig 5.2 pIC50 = 5.2 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 587 25 0 9 5.2 CCCCCCCCCCOCCOCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2ccsc2)c1)OC 10.1021/jm00087a023
10250897 30729 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 408 5 0 4 4.0 N#CC(c1cccnc1)N1CCN(C(=O)/C(=C/c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL133742 30729 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 408 5 0 4 4.0 N#CC(c1cccnc1)N1CCN(C(=O)/C(=C/c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
44350424 18286 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 592 22 1 8 5.8 CCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL1180478 18286 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 592 22 1 8 5.8 CCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL127419 18286 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 592 22 1 8 5.8 CCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
21276953 11742 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 564 9 2 7 6.2 CCO/C(O)=C1\C(COCCn2c(C)nc3ccccc32)=NC(C)=C(C(=O)NC(C)(C)C)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
CHEMBL104843 11742 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 564 9 2 7 6.2 CCO/C(O)=C1\C(COCCn2c(C)nc3ccccc32)=NC(C)=C(C(=O)NC(C)(C)C)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
3075901 209668 4 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 602 13 0 10 3.7 CCC(CC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL6270 209668 4 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 602 13 0 10 3.7 CCC(CC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
14785948 18934 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 545 21 0 4 8.3 CCCCCCCCCCCCCCCCCC1CCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL1184195 18934 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 545 21 0 4 8.3 CCCCCCCCCCCCCCCCCC1CCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL338519 18934 0 None - 1 Guinea pig 7.2 pIC50 = 7.2 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 545 21 0 4 8.3 CCCCCCCCCCCCCCCCCC1CCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
44350248 18235 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.6 CCCCCCCCCCCCCCCNOC(=O)CC1CCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL1180376 18235 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.6 CCCCCCCCCCCCCCCNOC(=O)CC1CCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL124394 18235 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.6 CCCCCCCCCCCCCCCNOC(=O)CC1CCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
10384542 29356 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 370 4 0 4 3.2 N#CC(c1cccnc1)N1CCN(C(=O)Cc2ccc3ccccc3c2)CC1 10.1021/jm00100a018
CHEMBL132636 29356 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 370 4 0 4 3.2 N#CC(c1cccnc1)N1CCN(C(=O)Cc2ccc3ccccc3c2)CC1 10.1021/jm00100a018
6078 7387 22 None 29 2 Guinea pig 7.1 pIC50 = 7.1 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 467 2 0 7 3.2 O=C(C1Cc2c(C1)c1c(s2)n2c(C)nnc2CN=C1c1ccccc1Cl)N1CCOCC1 10.1021/jm00018a011
65923 7387 22 None 29 2 Guinea pig 7.1 pIC50 = 7.1 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 467 2 0 7 3.2 O=C(C1Cc2c(C1)c1c(s2)n2c(C)nnc2CN=C1c1ccccc1Cl)N1CCOCC1 10.1021/jm00018a011
CHEMBL325439 7387 22 None 29 2 Guinea pig 7.1 pIC50 = 7.1 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 467 2 0 7 3.2 O=C(C1Cc2c(C1)c1c(s2)n2c(C)nnc2CN=C1c1ccccc1Cl)N1CCOCC1 10.1021/jm00018a011
6078 7387 22 None 29 2 Guinea pig 7.1 pIC50 = 7.1 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 467 2 0 7 3.2 O=C(C1Cc2c(C1)c1c(s2)n2c(C)nnc2CN=C1c1ccccc1Cl)N1CCOCC1 10.1021/jm00018a012
65923 7387 22 None 29 2 Guinea pig 7.1 pIC50 = 7.1 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 467 2 0 7 3.2 O=C(C1Cc2c(C1)c1c(s2)n2c(C)nnc2CN=C1c1ccccc1Cl)N1CCOCC1 10.1021/jm00018a012
CHEMBL325439 7387 22 None 29 2 Guinea pig 7.1 pIC50 = 7.1 Functional
In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsIn vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit platelets
ChEMBL 467 2 0 7 3.2 O=C(C1Cc2c(C1)c1c(s2)n2c(C)nnc2CN=C1c1ccccc1Cl)N1CCOCC1 10.1021/jm00018a012
14786007 18931 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 591 23 0 6 8.0 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(=O)OCC)C1 10.1021/jm00105a058
CHEMBL1184192 18931 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 591 23 0 6 8.0 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(=O)OCC)C1 10.1021/jm00105a058
CHEMBL338368 18931 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 591 23 0 6 8.0 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(=O)OCC)C1 10.1021/jm00105a058
10345945 28684 0 None - 1 Guinea pig 4.1 pIC50 = 4.1 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 502 10 0 8 2.7 COc1cc(CCC(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC 10.1021/jm00100a018
CHEMBL132028 28684 0 None - 1 Guinea pig 4.1 pIC50 = 4.1 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 502 10 0 8 2.7 COc1cc(CCC(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC 10.1021/jm00100a018
10316662 11082 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 363 5 1 5 2.2 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(N)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL100853 11082 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 363 5 1 5 2.2 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(N)c2ccccc2)CC1 10.1021/jm00072a019
6324617 196342 27 None -2 2 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 424 0 3 10 -1.4 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6O)O[C@@]4(C(=O)O5)[C@@]12O 10.1021/jm00060a006
CHEMBL514432 196342 27 None -2 2 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 424 0 3 10 -1.4 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6O)O[C@@]4(C(=O)O5)[C@@]12O 10.1021/jm00060a006
9980372 172140 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 434 6 0 4 4.5 N#Cc1cccc(C(C#N)N2CCN(C(=O)CC(c3ccccc3)c3ccccc3)CC2)c1 10.1021/jm00100a018
CHEMBL423711 172140 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 434 6 0 4 4.5 N#Cc1cccc(C(C#N)N2CCN(C(=O)CC(c3ccccc3)c3ccccc3)CC2)c1 10.1021/jm00100a018
10435103 215195 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 476 6 1 5 3.7 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(O)(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm00072a019
CHEMBL99794 215195 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 476 6 1 5 3.7 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(O)(c2ccc(F)cc2)c2ccc(F)cc2)CC1 10.1021/jm00072a019
11744704 115271 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 454 8 1 6 3.4 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NCc2cccnc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL319960 115271 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 454 8 1 6 3.4 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NCc2cccnc2)c2ccccc2)CC1 10.1021/jm00072a019
107757 8005 3 None -4 2 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1021/jm00121a012
1852 8005 3 None -4 2 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1021/jm00121a012
CHEMBL1180101 8005 3 None -4 2 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1021/jm00121a012
10361810 172112 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 370 4 0 4 3.2 N#CC(c1cccnc1)N1CCN(C(=O)Cc2cccc3ccccc23)CC1 10.1021/jm00100a018
CHEMBL423524 172112 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 370 4 0 4 3.2 N#CC(c1cccnc1)N1CCN(C(=O)Cc2cccc3ccccc23)CC1 10.1021/jm00100a018
44332558 11508 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 470 8 0 5 4.8 CO/N=C(/C)C(c1cccnc1C)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL103694 11508 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 470 8 0 5 4.8 CO/N=C(/C)C(c1cccnc1C)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
107681 8004 29 None -45 2 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 592 27 1 8 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)(OCC[n+]1ccsc1)[O-])OC 10.1021/jm00121a012
6079 8004 29 None -45 2 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 592 27 1 8 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)(OCC[n+]1ccsc1)[O-])OC 10.1021/jm00121a012
CHEMBL295212 8004 29 None -45 2 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 592 27 1 8 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)(OCC[n+]1ccsc1)[O-])OC 10.1021/jm00121a012
44372649 18434 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 600 27 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+](C)(C)C)C(=O)CCC)OC 10.1021/jm00121a012
CHEMBL1181102 18434 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 600 27 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+](C)(C)C)C(=O)CCC)OC 10.1021/jm00121a012
CHEMBL155650 18434 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 600 27 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+](C)(C)C)C(=O)CCC)OC 10.1021/jm00121a012
10321839 11476 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 456 7 0 5 4.6 Cc1ncccc1C(C#N)N1CCN(C(=O)CSC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL103477 11476 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 456 7 0 5 4.6 Cc1ncccc1C(C#N)N1CCN(C(=O)CSC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
14992445 185255 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 607 21 0 9 6.1 CCCCCCCCOCCOCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1OC 10.1021/jm00087a023
CHEMBL46643 185255 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 607 21 0 9 6.1 CCCCCCCCOCCOCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1OC 10.1021/jm00087a023
44350391 18257 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL1180409 18257 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL125576 18257 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL128034 18257 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 590 22 1 7 6.4 CCCCCCCCCCCCCCCNOC(=O)CC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL317911 114170 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 586 10 2 9 5.8 CCO/C(O)=C1\C(COCCn2c(C)nc3cnccc32)=NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
CHEMBL318391 114246 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Inhibitory effect on PAF induced platelets aggregation in rabbitInhibitory effect on PAF induced platelets aggregation in rabbit
ChEMBL 586 10 2 9 5.8 CCO/C(O)=C1\C(COCCn2c(C)nc3cccnc32)=NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1016/0960-894X(95)00542-7
14785973 18264 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL1180435 18264 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL126302 18264 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL126981 18264 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
14785956 18261 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL1180425 18261 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL126016 18261 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL419779 18261 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
14785956 18261 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL1180425 18261 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL126016 18261 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
CHEMBL419779 18261 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.4 CCCCCCCCCCCCCCCCOCC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00105a058
10457336 11270 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 468 7 1 6 3.1 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)c2cccnc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL102070 11270 0 None - 1 Guinea pig 8.1 pIC50 = 8.1 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 468 7 1 6 3.1 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)c2cccnc2)c2ccccc2)CC1 10.1021/jm00072a019
10433272 114205 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 438 7 0 4 4.7 Cc1ncccc1C(C#N)N1CCN(C(=O)CCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL318159 114205 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 438 7 0 4 4.7 Cc1ncccc1C(C#N)N1CCN(C(=O)CCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
10077575 102441 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 617 12 1 10 3.5 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)NC(C)C(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL258053 102441 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 617 12 1 10 3.5 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)NC(C)C(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
3075899 209540 4 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 642 11 0 10 4.2 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)c3ccccc3Cl)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL6203 209540 4 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 642 11 0 10 4.2 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)c3ccccc3Cl)C2)cc(OC)c1OC 10.1021/jm00060a006
14785946 19148 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 517 19 0 4 7.5 CCCCCCCCCCCCCCCC1CCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL1185567 19148 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 517 19 0 4 7.5 CCCCCCCCCCCCCCCC1CCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL421618 19148 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 517 19 0 4 7.5 CCCCCCCCCCCCCCCC1CCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
14786015 19145 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 547 24 1 4 7.9 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)NCc2cc[n+](CC)cc2)C1 10.1021/jm00105a058
CHEMBL1185534 19145 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 547 24 1 4 7.9 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)NCc2cc[n+](CC)cc2)C1 10.1021/jm00105a058
CHEMBL419786 19145 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 547 24 1 4 7.9 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)NCc2cc[n+](CC)cc2)C1 10.1021/jm00105a058
14885630 40549 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 396 0 0 2 4.4 CC(=O)N1CCC(=C2c3ccc(Br)cc3CCc3cccnc32)CC1 10.1021/jm00105a069
CHEMBL142268 40549 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 396 0 0 2 4.4 CC(=O)N1CCC(=C2c3ccc(Br)cc3CCc3cccnc32)CC1 10.1021/jm00105a069
44290499 177604 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 601 21 0 6 9.0 CCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(CC)c1 10.1021/jm00087a023
CHEMBL445355 177604 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 601 21 0 6 9.0 CCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(CC)c1 10.1021/jm00087a023
10098082 170103 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 517 8 0 6 3.2 Cc1ncccc1C(C#N)N1CCN(C(=O)CN(C(c2ccccc2)c2ccccc2)S(C)(=O)=O)CC1 10.1021/jm00072a019
CHEMBL418989 170103 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 517 8 0 6 3.2 Cc1ncccc1C(C#N)N1CCN(C(=O)CN(C(c2ccccc2)c2ccccc2)S(C)(=O)=O)CC1 10.1021/jm00072a019
14885629 41752 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 336 0 0 2 3.8 CC(=O)N1CCC(=C2c3cc(F)ccc3CCc3cccnc32)CC1 10.1021/jm00105a069
CHEMBL143272 41752 0 None - 1 Human 6.1 pIC50 = 6.1 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 336 0 0 2 3.8 CC(=O)N1CCC(=C2c3cc(F)ccc3CCc3cccnc32)CC1 10.1021/jm00105a069
10344611 11081 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 469 7 1 7 2.5 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)c2cnccn2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL100851 11081 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 469 7 1 7 2.5 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)c2cnccn2)c2ccccc2)CC1 10.1021/jm00072a019
44372028 18458 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 544 25 1 5 6.8 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C)CC[N+](C)(C)C)OC 10.1021/jm00121a012
CHEMBL1181181 18458 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 544 25 1 5 6.8 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C)CC[N+](C)(C)C)OC 10.1021/jm00121a012
CHEMBL158268 18458 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 544 25 1 5 6.8 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C)CC[N+](C)(C)C)OC 10.1021/jm00121a012
14786029 18259 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 440 22 0 2 7.8 CCCCCCCCCCCCCCC1COC(COCCCCCC[N+](C)(C)C)C1 10.1021/jm00105a058
CHEMBL1180413 18259 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 440 22 0 2 7.8 CCCCCCCCCCCCCCC1COC(COCCCCCC[N+](C)(C)C)C1 10.1021/jm00105a058
CHEMBL125680 18259 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 440 22 0 2 7.8 CCCCCCCCCCCCCCC1COC(COCCCCCC[N+](C)(C)C)C1 10.1021/jm00105a058
14785984 18953 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 563 22 0 6 6.7 CCCCCCCCCCCCCCCCOCC1OCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL1184230 18953 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 563 22 0 6 6.7 CCCCCCCCCCCCCCCCOCC1OCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL340247 18953 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 563 22 0 6 6.7 CCCCCCCCCCCCCCCCOCC1OCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
14785881 18247 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 480 23 0 3 8.5 CCCCCCCCCCCCCCC1COC(COCCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL1180392 18247 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 480 23 0 3 8.5 CCCCCCCCCCCCCCC1COC(COCCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL125078 18247 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 480 23 0 3 8.5 CCCCCCCCCCCCCCC1COC(COCCCCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
9826514 18451 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 481 19 0 2 7.6 CCCCCCCCCCCCCCOc1ccc(CN(Cc2cccc[n+]2CC)C(C)=O)cc1 10.1021/jm00057a008
CHEMBL1181156 18451 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 481 19 0 2 7.6 CCCCCCCCCCCCCCOc1ccc(CN(Cc2cccc[n+]2CC)C(C)=O)cc1 10.1021/jm00057a008
CHEMBL157330 18451 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 481 19 0 2 7.6 CCCCCCCCCCCCCCOc1ccc(CN(Cc2cccc[n+]2CC)C(C)=O)cc1 10.1021/jm00057a008
44268136 17903 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 726 26 1 7 9.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(=O)c2ccc(OC)cc2)S1 10.1016/0960-894X(95)00174-R
CHEMBL1178074 17903 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 726 26 1 7 9.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(=O)c2ccc(OC)cc2)S1 10.1016/0960-894X(95)00174-R
CHEMBL12556 17903 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 726 26 1 7 9.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(=O)c2ccc(OC)cc2)S1 10.1016/0960-894X(95)00174-R
54582516 69949 1 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H](COC(=O)N(Cc1cccc[n+]1CC)C(C)=O)OC 10.1021/jm00121a012
CHEMBL1788193 69949 1 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H](COC(=O)N(Cc1cccc[n+]1CC)C(C)=O)OC 10.1021/jm00121a012
CHEMBL1789869 69949 1 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H](COC(=O)N(Cc1cccc[n+]1CC)C(C)=O)OC 10.1021/jm00121a012
12239330 117106 2 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 209 1 0 3 2.7 Cc1nc2cnccc2n1-c1ccccc1 10.1021/jm00018a011
CHEMBL323940 117106 2 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.
ChEMBL 209 1 0 3 2.7 Cc1nc2cnccc2n1-c1ccccc1 10.1021/jm00018a011
44372031 18452 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 515 25 1 5 6.6 CCCCCCCCCCCCCCCCCCOCC(COC(=O)NCC[N+](C)(C)C)OC(C)=O 10.1021/jm00121a012
CHEMBL1181162 18452 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 515 25 1 5 6.6 CCCCCCCCCCCCCCCCCCOCC(COC(=O)NCC[N+](C)(C)C)OC(C)=O 10.1021/jm00121a012
CHEMBL157596 18452 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 515 25 1 5 6.6 CCCCCCCCCCCCCCCCCCOCC(COC(=O)NCC[N+](C)(C)C)OC(C)=O 10.1021/jm00121a012
14785971 18278 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 533 20 0 5 6.6 CCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL1180463 18278 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 533 20 0 5 6.6 CCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
CHEMBL127010 18278 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 533 20 0 5 6.6 CCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1021/jm00105a058
44371931 18988 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 586 26 1 6 7.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CCC[N+](C)(C)C)C(C)=O)OC 10.1021/jm00121a012
CHEMBL1184365 18988 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 586 26 1 6 7.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CCC[N+](C)(C)C)C(C)=O)OC 10.1021/jm00121a012
CHEMBL346367 18988 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 586 26 1 6 7.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CCC[N+](C)(C)C)C(C)=O)OC 10.1021/jm00121a012
10366659 20419 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 453 9 1 5 3.6 N#CC(c1cccnc1)N1CCN(C(=O)CNCCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL1194514 20419 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 453 9 1 5 3.6 N#CC(c1cccnc1)N1CCN(C(=O)CNCCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL552805 20419 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 453 9 1 5 3.6 N#CC(c1cccnc1)N1CCN(C(=O)CNCCC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
10095446 11494 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 453 7 1 5 3.7 Cc1ncccc1C(C#N)N1CCN(C(=O)CNC(C)(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL103561 11494 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 453 7 1 5 3.7 Cc1ncccc1C(C#N)N1CCN(C(=O)CNC(C)(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
10252596 11258 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 438 7 1 4 3.6 C#CC(c1cccnc1C)N1CCN(C(=O)CNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL101957 11258 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 438 7 1 4 3.6 C#CC(c1cccnc1C)N1CCN(C(=O)CNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
14786023 18240 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 547 21 0 5 7.4 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(C(C)=O)c2cc[n+](CC)cc2)C1 10.1021/jm00105a058
CHEMBL1180383 18240 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 547 21 0 5 7.4 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(C(C)=O)c2cc[n+](CC)cc2)C1 10.1021/jm00105a058
CHEMBL124562 18240 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 547 21 0 5 7.4 CCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(C(C)=O)c2cc[n+](CC)cc2)C1 10.1021/jm00105a058
44372256 18984 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 628 25 1 6 7.4 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+](C)(C)C)C(=O)N1CCCC1)OC 10.1021/jm00121a012
CHEMBL1184338 18984 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 628 25 1 6 7.4 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+](C)(C)C)C(=O)N1CCCC1)OC 10.1021/jm00121a012
CHEMBL345213 18984 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 628 25 1 6 7.4 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+](C)(C)C)C(=O)N1CCCC1)OC 10.1021/jm00121a012
14966971 20349 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 385 6 1 3 4.7 O=C(CC(c1ccccc1)c1ccccc1)N1CCC(Nc2cccnc2)CC1 10.1021/jm00100a018
CHEMBL1194036 20349 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 385 6 1 3 4.7 O=C(CC(c1ccccc1)c1ccccc1)N1CCC(Nc2cccnc2)CC1 10.1021/jm00100a018
CHEMBL3216628 20349 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 385 6 1 3 4.7 O=C(CC(c1ccccc1)c1ccccc1)N1CCC(Nc2cccnc2)CC1 10.1021/jm00100a018
10343902 114339 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 453 7 0 6 3.6 Cc1ncccc1C(C#N)N1CCN(C(=O)CON=C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL318908 114339 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
In vitro inhibition of PAF-induced platelet aggregation in male rabbitsIn vitro inhibition of PAF-induced platelet aggregation in male rabbits
ChEMBL 453 7 0 6 3.6 Cc1ncccc1C(C#N)N1CCN(C(=O)CON=C(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
14885633 128284 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 334 0 1 3 3.3 CC(=O)N1CCC(=C2c3ccc(O)cc3CCc3cccnc32)CC1 10.1021/jm00105a069
CHEMBL358332 128284 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when challenged with 25 nM PAF.
ChEMBL 334 0 1 3 3.3 CC(=O)N1CCC(=C2c3ccc(O)cc3CCc3cccnc32)CC1 10.1021/jm00105a069
14992473 107994 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 615 21 0 7 8.6 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1C(C)=O 10.1021/jm00087a023
CHEMBL295916 107994 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 615 21 0 7 8.6 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1C(C)=O 10.1021/jm00087a023
3075899 209540 4 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 642 11 0 10 4.2 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)c3ccccc3Cl)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL6203 209540 4 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibition of PAF-induced rabbit platelet aggregationInhibition of PAF-induced rabbit platelet aggregation
ChEMBL 642 11 0 10 4.2 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)c3ccccc3Cl)C2)cc(OC)c1OC 10.1021/jm00060a006
44372033 18457 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 557 25 0 6 6.9 CCCCCCCCCCCCCCCCCCOCC(COC(=O)N(CC[N+](C)(C)C)C(C)=O)OC(C)=O 10.1021/jm00121a012
CHEMBL1181179 18457 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 557 25 0 6 6.9 CCCCCCCCCCCCCCCCCCOCC(COC(=O)N(CC[N+](C)(C)C)C(C)=O)OC(C)=O 10.1021/jm00121a012
CHEMBL158254 18457 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 557 25 0 6 6.9 CCCCCCCCCCCCCCCCCCOCC(COC(=O)N(CC[N+](C)(C)C)C(C)=O)OC(C)=O 10.1021/jm00121a012
10410156 116323 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 425 7 1 5 3.2 N#CC(c1cccnc1)N1CCN(C(=O)CNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL322184 116323 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 425 7 1 5 3.2 N#CC(c1cccnc1)N1CCN(C(=O)CNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL545771 116323 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 425 7 1 5 3.2 N#CC(c1cccnc1)N1CCN(C(=O)CNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
10389222 11029 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 453 8 1 5 4.0 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NCc2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL100497 11029 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 453 8 1 5 4.0 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NCc2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
10344522 11400 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 467 7 1 5 3.7 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL102918 11400 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 467 7 1 5 3.7 Cc1ncccc1C(C#N)N1CCN(C(=O)CC(NC(=O)c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
10410156 116323 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 425 7 1 5 3.2 N#CC(c1cccnc1)N1CCN(C(=O)CNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL322184 116323 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 425 7 1 5 3.2 N#CC(c1cccnc1)N1CCN(C(=O)CNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
CHEMBL545771 116323 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 425 7 1 5 3.2 N#CC(c1cccnc1)N1CCN(C(=O)CNC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00072a019
15123171 19010 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 547 21 0 5 7.3 CCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL1184477 19010 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 547 21 0 5 7.3 CCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
CHEMBL351410 19010 0 None - 1 Guinea pig 8.0 pIC50 = 8.0 Functional
In vitro inhibition of PAF induced aggregation of rabbit platelets.In vitro inhibition of PAF induced aggregation of rabbit platelets.
ChEMBL 547 21 0 5 7.3 CCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1021/jm00082a007
14992453 185415 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 657 18 0 6 10.2 CCCCCCCCCCCCOc1cc(C(C)(C)C)c(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)cc1C(C)(C)C 10.1021/jm00087a023
CHEMBL46754 185415 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 657 18 0 6 10.2 CCCCCCCCCCCCOc1cc(C(C)(C)C)c(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)cc1C(C)(C)C 10.1021/jm00087a023
10482349 74537 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.
ChEMBL 537 27 0 7 5.7 CCCCCCCCCCCC(=O)CCCCCCOC[C@@H](COP(=O)([O-])OCC[N+](C)(C)C)OC 10.1021/jm00007a018
CHEMBL1907928 74537 0 None - 1 Guinea pig 7.1 pIC50 = 7.1 Functional
PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.PAF agonism was measured as the IC50 for aggregation of washed rabbit platelets after incubation for 30 min at 37 C.
ChEMBL 537 27 0 7 5.7 CCCCCCCCCCCC(=O)CCCCCCOC[C@@H](COP(=O)([O-])OCC[N+](C)(C)C)OC 10.1021/jm00007a018
44290227 108158 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 603 21 0 7 8.4 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2ccccc2C[n+]2csc(C)c2)c1OC 10.1021/jm00087a023
CHEMBL297147 108158 0 None - 1 Guinea pig 6.1 pIC50 = 6.1 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 603 21 0 7 8.4 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2ccccc2C[n+]2csc(C)c2)c1OC 10.1021/jm00087a023
10096569 30514 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 477 6 0 3 5.6 N#CC(c1cccc(C(F)(F)F)c1)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
CHEMBL133555 30514 0 None - 1 Guinea pig 5.1 pIC50 = 5.1 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 477 6 0 3 5.6 N#CC(c1cccc(C(F)(F)F)c1)N1CCN(C(=O)CC(c2ccccc2)c2ccccc2)CC1 10.1021/jm00100a018
14992353 184128 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 675 27 0 8 8.9 CCCCCCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)OC)c1 10.1021/jm00087a023
CHEMBL46375 184128 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 675 27 0 8 8.9 CCCCCCCCCCCCCCCCOc1cccc(OCC(COP(=O)([O-])Oc2cccc(C[n+]3ccsc3)c2)OC)c1 10.1021/jm00087a023
14992517 108184 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 583 21 0 6 8.0 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccccc3)c2)c1OC 10.1021/jm00087a023
CHEMBL297298 108184 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 583 21 0 6 8.0 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3ccccc3)c2)c1OC 10.1021/jm00087a023
1859 7223 62 None -1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00100a018
1860 7223 62 None -1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00100a018
65889 7223 62 None -1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00100a018
CHEMBL280164 7223 62 None -1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00100a018
1859 7223 62 None -1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00072a019
1860 7223 62 None -1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00072a019
65889 7223 62 None -1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00072a019
CHEMBL280164 7223 62 None -1 2 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of PAF-induced platelet aggregationInhibition of PAF-induced platelet aggregation
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00072a019
54050884 85124 1 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@@H](COC(=O)N(Cc1cccc[n+]1CC)C(C)=O)OC 10.1021/jm00121a012
CHEMBL2093039 85124 1 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@@H](COC(=O)N(Cc1cccc[n+]1CC)C(C)=O)OC 10.1021/jm00121a012
CHEMBL2110057 85124 1 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@@H](COC(=O)N(Cc1cccc[n+]1CC)C(C)=O)OC 10.1021/jm00121a012
14992335 107899 0 None - 1 Guinea pig 4.0 pIC50 = 4.0 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 631 24 0 7 8.3 CCCCCCCCCCCCCCc1cccc(OCC(COP(=O)([O-])Oc2ccc(C[n+]3ccsc3)cc2)OC)c1 10.1021/jm00087a023
CHEMBL295205 107899 0 None - 1 Guinea pig 4.0 pIC50 = 4.0 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 631 24 0 7 8.3 CCCCCCCCCCCCCCc1cccc(OCC(COP(=O)([O-])Oc2ccc(C[n+]3ccsc3)cc2)OC)c1 10.1021/jm00087a023
19829172 18437 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 612 25 1 7 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1csc[n+]1CC)C(C)=O)OC 10.1021/jm00121a012
CHEMBL1181108 18437 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 612 25 1 7 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1csc[n+]1CC)C(C)=O)OC 10.1021/jm00121a012
CHEMBL155821 18437 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 612 25 1 7 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1csc[n+]1CC)C(C)=O)OC 10.1021/jm00121a012
9996625 20416 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 328 8 0 4 3.2 CCCCCCCC(=O)N1CCN(C(C#N)c2cccnc2)CC1 10.1021/jm00100a018
CHEMBL1194494 20416 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 328 8 0 4 3.2 CCCCCCCC(=O)N1CCN(C(C#N)c2cccnc2)CC1 10.1021/jm00100a018
CHEMBL552771 20416 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 328 8 0 4 3.2 CCCCCCCC(=O)N1CCN(C(C#N)c2cccnc2)CC1 10.1021/jm00100a018
14992323 185656 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 654 27 1 8 8.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)([O-])Oc1cccc(C[n+]2ccsc2)c1)OC 10.1021/jm00087a023
CHEMBL46976 185656 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 654 27 1 8 8.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)([O-])Oc1cccc(C[n+]2ccsc2)c1)OC 10.1021/jm00087a023
44372274 18442 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 614 25 1 7 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+]1(C)CCOCC1)C(C)=O)OC 10.1021/jm00121a012
CHEMBL1181126 18442 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 614 25 1 7 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+]1(C)CCOCC1)C(C)=O)OC 10.1021/jm00121a012
CHEMBL156510 18442 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 614 25 1 7 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(CC[N+]1(C)CCOCC1)C(C)=O)OC 10.1021/jm00121a012
14785895 18698 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 566 27 0 5 8.8 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)CCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL1182717 18698 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 566 27 0 5 8.8 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)CCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
CHEMBL262465 18698 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 566 27 0 5 8.8 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)CCCCC[n+]2ccsc2)C1 10.1021/jm00105a058
44267808 18737 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 590 22 1 6 6.7 CCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL1182959 18737 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 590 22 1 6 6.7 CCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL274110 18737 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 590 22 1 6 6.7 CCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
14992393 107958 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 580 25 0 7 6.7 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2ccn(C)c2)c1)OC 10.1021/jm00087a023
CHEMBL295639 107958 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 580 25 0 7 6.7 CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])Oc1cccc(C[n+]2ccn(C)c2)c1)OC 10.1021/jm00087a023
44371925 18485 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 620 26 1 6 7.9 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1cccc[n+]1CCC)C(C)=O)OC 10.1021/jm00121a012
CHEMBL1181259 18485 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 620 26 1 6 7.9 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1cccc[n+]1CCC)C(C)=O)OC 10.1021/jm00121a012
CHEMBL160888 18485 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 620 26 1 6 7.9 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1cccc[n+]1CCC)C(C)=O)OC 10.1021/jm00121a012
14785999 18296 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 591 24 0 6 7.5 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL1180491 18296 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 591 24 0 6 7.5 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL127887 18296 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 591 24 0 6 7.5 CCCCCCCCCCCCCCCCCCOCC1COC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
120984 209617 23 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 474 8 0 8 2.3 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC 10.1021/jm00100a018
CHEMBL6244 209617 23 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.
ChEMBL 474 8 0 8 2.3 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC 10.1021/jm00100a018
44268145 17905 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 547 22 0 5 7.1 CCCCCCCCCCCCCCCCOC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL1178081 17905 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 547 22 0 5 7.1 CCCCCCCCCCCCCCCCOC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL12708 17905 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 547 22 0 5 7.1 CCCCCCCCCCCCCCCCOC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
21463428 17896 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 637 26 1 4 10.4 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCC[n+]2cccc3ccccc32)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178060 17896 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 637 26 1 4 10.4 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCC[n+]2cccc3ccccc32)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL12368 17896 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets.
ChEMBL 637 26 1 4 10.4 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCC[n+]2cccc3ccccc32)CCCC1 10.1016/0960-894X(95)00173-Q
9851823 18422 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 481 17 0 3 6.8 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2C)C(C)=O)cc1 10.1021/jm00057a008
CHEMBL1181058 18422 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 481 17 0 3 6.8 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2C)C(C)=O)cc1 10.1021/jm00057a008
CHEMBL154205 18422 0 None - 1 Guinea pig 6.0 pIC50 = 6.0 Functional
Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaInhibition of PAF-induced platelet aggregation in rabbit platelet rich plasma
ChEMBL 481 17 0 3 6.8 CCCCCCCCCCCCCCOc1ccc(C(=O)N(Cc2cccc[n+]2C)C(C)=O)cc1 10.1021/jm00057a008
14992511 103463 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 617 21 0 7 8.7 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3C)c2)c1OC 10.1021/jm00087a023
CHEMBL263933 103463 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 617 21 0 7 8.7 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3C)c2)c1OC 10.1021/jm00087a023
19829201 18446 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 612 25 1 7 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1scc[n+]1CC)C(C)=O)OC 10.1021/jm00121a012
CHEMBL1181146 18446 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 612 25 1 7 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1scc[n+]1CC)C(C)=O)OC 10.1021/jm00121a012
CHEMBL156972 18446 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
ChEMBL 612 25 1 7 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(Cc1scc[n+]1CC)C(C)=O)OC 10.1021/jm00121a012
10414574 18081 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 400 13 0 4 5.0 CCCCCCOc1c(Cl)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL1179271 18081 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 400 13 0 4 5.0 CCCCCCOc1c(Cl)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL67232 18081 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Activity against adenosine diphosphate (ADP) induced platelet aggregationActivity against adenosine diphosphate (ADP) induced platelet aggregation
ChEMBL 400 13 0 4 5.0 CCCCCCOc1c(Cl)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
14992413 108010 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 601 22 0 6 9.2 CCCCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)cc1 10.1021/jm00087a023
CHEMBL296072 108010 0 None - 1 Guinea pig 5.0 pIC50 = 5.0 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 601 22 0 6 9.2 CCCCCCCCCCCCCCCCOc1ccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)cc1 10.1021/jm00087a023
44268122 17900 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL1178068 17900 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL12439 17900 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL12882 17900 0 None - 1 Guinea pig 7.0 pIC50 = 7.0 Functional
In vitro inhibitory activity against PAF-induced aggregation of rabbit plateletsIn vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
14785950 18248 0 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.5 CCCCCCCCCCCCCCCCOCC1CCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL1180393 18248 0 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.5 CCCCCCCCCCCCCCCCOCC1CCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
CHEMBL125080 18248 0 None - 1 Guinea pig 7.0 pIC50 = 7 Functional
Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%Inhibitory activity expressed as the concentration required to inhibit platelet-activating factor (PAF) induced maximum aggregation by 50%
ChEMBL 561 22 0 5 7.5 CCCCCCCCCCCCCCCCOCC1CCC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1021/jm00105a058
14992467 178996 0 None - 1 Guinea pig 5.0 pIC50 = 5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 641 20 0 6 9.7 CCCCCCCCCCCCCCOc1cc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(Cl)cc1Cl 10.1021/jm00087a023
CHEMBL44740 178996 0 None - 1 Guinea pig 5.0 pIC50 = 5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 641 20 0 6 9.7 CCCCCCCCCCCCCCOc1cc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c(Cl)cc1Cl 10.1021/jm00087a023
14992407 190294 0 None - 1 Guinea pig 5.0 pIC50 = 5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 573 20 0 6 8.4 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1 10.1021/jm00087a023
CHEMBL47998 190294 0 None - 1 Guinea pig 5.0 pIC50 = 5 Functional
Inhibition of PAF induced platelet aggregation in rabbitInhibition of PAF induced platelet aggregation in rabbit
ChEMBL 573 20 0 6 8.4 CCCCCCCCCCCCCCOc1cccc(OP(=O)([O-])Oc2cccc(C[n+]3csc(C)c3)c2)c1 10.1021/jm00087a023
10344174 209764 0 None - 0 Guinea pig 9.2 pKi = 9.2 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 458 3 1 6 3.9 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(Br)cc21 10.1021/jm00039a015
CHEMBL63100 209764 0 None - 0 Guinea pig 9.2 pKi = 9.2 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 458 3 1 6 3.9 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(Br)cc21 10.1021/jm00039a015
10324525 215079 0 None - 0 Guinea pig 9.2 pKi = 9.2 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 524 6 0 6 5.8 CN(C)C(=O)Cn1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
CHEMBL99053 215079 0 None - 0 Guinea pig 9.2 pKi = 9.2 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 524 6 0 6 5.8 CN(C)C(=O)Cn1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
9999825 209899 0 None - 0 Guinea pig 9.1 pKi = 9.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 380 3 1 6 3.2 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL64057 209899 0 None - 0 Guinea pig 9.1 pKi = 9.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 380 3 1 6 3.2 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
10005564 201621 0 None - 0 Guinea pig 9.0 pKi = 9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 484 5 1 7 4.4 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(C(=O)c3ccccc3)cc21 10.1021/jm00039a015
CHEMBL539673 201621 0 None - 0 Guinea pig 9.0 pKi = 9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 484 5 1 7 4.4 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(C(=O)c3ccccc3)cc21 10.1021/jm00039a015
10070431 209435 0 None - 0 Guinea pig 9.0 pKi = 9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 414 3 1 6 3.8 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(Cl)cc21 10.1021/jm00039a015
CHEMBL61416 209435 0 None - 0 Guinea pig 9.0 pKi = 9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 414 3 1 6 3.8 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(Cl)cc21 10.1021/jm00039a015
10476623 209941 0 None - 0 Guinea pig 9.0 pKi = 9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 409 3 1 7 4.4 CC(C)(C)OC(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL64214 209941 0 None - 0 Guinea pig 9.0 pKi = 9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 409 3 1 7 4.4 CC(C)(C)OC(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
11756259 210061 0 None - 0 Guinea pig 9.0 pKi = 9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 515 6 1 8 6.0 CC(C)(C)OC(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(OCc3ccccc3)cc21 10.1021/jm00039a015
CHEMBL64691 210061 0 None - 0 Guinea pig 9.0 pKi = 9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 515 6 1 8 6.0 CC(C)(C)OC(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(OCc3ccccc3)cc21 10.1021/jm00039a015
10047478 18039 0 None - 0 Guinea pig 9.0 pKi = 9.0 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 6 2 5 4.7 O=C(c1c[nH]c2c(OCc3ccccc3)cccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL1179099 18039 0 None - 0 Guinea pig 9.0 pKi = 9.0 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 6 2 5 4.7 O=C(c1c[nH]c2c(OCc3ccccc3)cccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL60081 18039 0 None - 0 Guinea pig 9.0 pKi = 9.0 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 6 2 5 4.7 O=C(c1c[nH]c2c(OCc3ccccc3)cccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
10092094 209998 0 None - 0 Guinea pig 8.9 pKi = 8.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 395 6 1 7 3.2 CCOC(=O)Cn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL64428 209998 0 None - 0 Guinea pig 8.9 pKi = 8.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 395 6 1 7 3.2 CCOC(=O)Cn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
10480304 109588 0 None - 0 Guinea pig 8.9 pKi = 8.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 480 3 1 6 4.6 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(C#Cc3ccccc3)cc21 10.1021/jm00039a015
CHEMBL305372 109588 0 None - 0 Guinea pig 8.9 pKi = 8.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 480 3 1 6 4.6 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(C#Cc3ccccc3)cc21 10.1021/jm00039a015
10345318 18802 0 None - 0 Guinea pig 8.9 pKi = 8.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 486 6 1 7 4.7 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(OCc3ccccc3)cc21 10.1021/jm00039a015
CHEMBL1183374 18802 0 None - 0 Guinea pig 8.9 pKi = 8.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 486 6 1 7 4.7 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(OCc3ccccc3)cc21 10.1021/jm00039a015
CHEMBL293662 18802 0 None - 0 Guinea pig 8.9 pKi = 8.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 486 6 1 7 4.7 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(OCc3ccccc3)cc21 10.1021/jm00039a015
10070036 107693 0 None - 0 Guinea pig 8.9 pKi = 8.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 408 5 1 6 3.9 CCN(CC)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL293906 107693 0 None - 0 Guinea pig 8.9 pKi = 8.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 408 5 1 6 3.9 CCN(CC)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
10477335 210008 0 None - 0 Guinea pig 8.8 pKi = 8.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 422 3 1 7 2.9 O=C(c1cn(C(=O)N2CCOCC2)c2ccccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL64464 210008 0 None - 0 Guinea pig 8.8 pKi = 8.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 422 3 1 7 2.9 O=C(c1cn(C(=O)N2CCOCC2)c2ccccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
10254533 175878 0 None - 0 Guinea pig 8.8 pKi = 8.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 479 8 2 8 3.7 COc1cc(C(=O)c2cccc(NC(=O)[C@@H]3CSC(c4cccnc4)N3)c2)cc(OC)c1OC 10.1021/jm00039a015
CHEMBL439937 175878 0 None - 0 Guinea pig 8.8 pKi = 8.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 479 8 2 8 3.7 COc1cc(C(=O)c2cccc(NC(=O)[C@@H]3CSC(c4cccnc4)N3)c2)cc(OC)c1OC 10.1021/jm00039a015
10251285 209626 0 None - 0 Guinea pig 8.8 pKi = 8.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 6 2 5 4.7 O=C(c1c[nH]c2cc(OCc3ccccc3)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL62497 209626 0 None - 0 Guinea pig 8.8 pKi = 8.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 6 2 5 4.7 O=C(c1c[nH]c2cc(OCc3ccccc3)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
10048500 209703 0 None - 0 Guinea pig 8.8 pKi = 8.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 433 6 2 5 4.9 O=C(c1c[nH]c2cc(OCc3ccc(F)cc3)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL62830 209703 0 None - 0 Guinea pig 8.8 pKi = 8.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 433 6 2 5 4.9 O=C(c1c[nH]c2cc(OCc3ccc(F)cc3)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
23986866 215151 0 None - 0 Guinea pig 8.8 pKi = 8.8 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 526 5 0 7 6.3 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(Oc3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
CHEMBL99528 215151 0 None - 0 Guinea pig 8.8 pKi = 8.8 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 526 5 0 7 6.3 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(Oc3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
10255558 107318 0 None - 0 Guinea pig 8.7 pKi = 8.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 504 6 1 7 4.9 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(OCc3ccc(F)cc3)cc21 10.1021/jm00039a015
CHEMBL291372 107318 0 None - 0 Guinea pig 8.7 pKi = 8.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 504 6 1 7 4.9 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(OCc3ccc(F)cc3)cc21 10.1021/jm00039a015
10475985 209810 0 None - 0 Guinea pig 8.7 pKi = 8.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 398 3 1 6 3.3 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(F)cc21 10.1021/jm00039a015
CHEMBL63383 209810 0 None - 0 Guinea pig 8.7 pKi = 8.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 398 3 1 6 3.3 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(F)cc21 10.1021/jm00039a015
10454763 210049 0 None - 0 Guinea pig 8.7 pKi = 8.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 419 5 2 5 5.1 O=C(c1c[nH]c2cc(Oc3ccc(F)cc3)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL64636 210049 0 None - 0 Guinea pig 8.7 pKi = 8.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 419 5 2 5 5.1 O=C(c1c[nH]c2cc(Oc3ccc(F)cc3)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
10433379 107649 0 None - 0 Guinea pig 8.0 pKi = 8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 440 5 1 8 3.2 COc1cc2c(C(=O)[C@@H]3CSC(c4cccnc4)N3)cn(C(=O)N(C)C)c2cc1OC 10.1021/jm00039a015
CHEMBL293641 107649 0 None - 0 Guinea pig 8.0 pKi = 8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 440 5 1 8 3.2 COc1cc2c(C(=O)[C@@H]3CSC(c4cccnc4)N3)cn(C(=O)N(C)C)c2cc1OC 10.1021/jm00039a015
10052663 109541 0 None - 0 Guinea pig 8.0 pKi = 8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 528 6 1 8 4.5 O=C(c1cn(C(=O)N2CCOCC2)c2cc(OCc3ccccc3)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL305145 109541 0 None - 0 Guinea pig 8.0 pKi = 8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 528 6 1 8 4.5 O=C(c1cn(C(=O)N2CCOCC2)c2cc(OCc3ccccc3)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
15292722 215049 0 None - 0 Guinea pig 8.0 pKi = 8 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 496 4 1 6 5.9 CNC(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
CHEMBL98874 215049 0 None - 0 Guinea pig 8.0 pKi = 8 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 496 4 1 6 5.9 CNC(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
15292724 114092 0 None - 0 Guinea pig 8.0 pKi = 8.0 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 493 4 0 7 5.5 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3cccnc3)cc21 10.1016/0960-894X(95)00509-R
CHEMBL317357 114092 0 None - 0 Guinea pig 8.0 pKi = 8.0 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 493 4 0 7 5.5 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3cccnc3)cc21 10.1016/0960-894X(95)00509-R
15292704 215222 0 None - 0 Guinea pig 7.0 pKi = 7.0 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 445 3 0 7 5.6 CC(C)(C)OC(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccccc21 10.1016/0960-894X(95)00509-R
CHEMBL99976 215222 0 None - 0 Guinea pig 7.0 pKi = 7.0 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 445 3 0 7 5.6 CC(C)(C)OC(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccccc21 10.1016/0960-894X(95)00509-R
9998987 18050 0 None - 0 Guinea pig 7.9 pKi = 7.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 366 3 2 6 2.8 CNC(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL1179147 18050 0 None - 0 Guinea pig 7.9 pKi = 7.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 366 3 2 6 2.8 CNC(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL62308 18050 0 None - 0 Guinea pig 7.9 pKi = 7.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 366 3 2 6 2.8 CNC(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
10431597 18798 0 None - 0 Guinea pig 7.9 pKi = 7.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 408 3 1 6 3.8 Cc1ccc2c(c1)c(C(=O)[C@@H]1CSC(c3cccnc3)N1)c(C)n2C(=O)N(C)C 10.1021/jm00039a015
CHEMBL1183360 18798 0 None - 0 Guinea pig 7.9 pKi = 7.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 408 3 1 6 3.8 Cc1ccc2c(c1)c(C(=O)[C@@H]1CSC(c3cccnc3)N1)c(C)n2C(=O)N(C)C 10.1021/jm00039a015
CHEMBL292508 18798 0 None - 0 Guinea pig 7.9 pKi = 7.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 408 3 1 6 3.8 Cc1ccc2c(c1)c(C(=O)[C@@H]1CSC(c3cccnc3)N1)c(C)n2C(=O)N(C)C 10.1021/jm00039a015
15292731 215183 0 None - 0 Guinea pig 6.9 pKi = 6.9 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 522 6 0 7 6.0 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2cc(OCc3ccccc3)ccc21 10.1016/0960-894X(95)00509-R
CHEMBL99721 215183 0 None - 0 Guinea pig 6.9 pKi = 6.9 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 522 6 0 7 6.0 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2cc(OCc3ccccc3)ccc21 10.1016/0960-894X(95)00509-R
10001907 210035 0 None - 0 Guinea pig 7.9 pKi = 7.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 6 2 5 4.7 O=C(c1c[nH]c2cccc(OCc3ccccc3)c12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL64587 210035 0 None - 0 Guinea pig 7.9 pKi = 7.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 6 2 5 4.7 O=C(c1c[nH]c2cccc(OCc3ccccc3)c12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
44330289 114064 0 None - 0 Guinea pig 7.9 pKi = 7.9 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 506 5 0 6 6.0 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(Cc3ccccc3)cc21 10.1016/0960-894X(95)00509-R
CHEMBL317116 114064 0 None - 0 Guinea pig 7.9 pKi = 7.9 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 506 5 0 6 6.0 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(Cc3ccccc3)cc21 10.1016/0960-894X(95)00509-R
131925 108549 17 None - 1 Guinea pig 7.9 pKi = 7.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 510 12 1 9 3.9 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO 10.1021/jm00039a015
CHEMBL299944 108549 17 None - 1 Guinea pig 7.9 pKi = 7.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 510 12 1 9 3.9 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO 10.1021/jm00039a015
10413137 210075 0 None - 0 Guinea pig 7.9 pKi = 7.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 486 6 1 7 4.7 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2cccc(OCc3ccccc3)c21 10.1021/jm00039a015
CHEMBL64745 210075 0 None - 0 Guinea pig 7.9 pKi = 7.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 486 6 1 7 4.7 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2cccc(OCc3ccccc3)c21 10.1021/jm00039a015
10475183 107814 0 None - 0 Guinea pig 7.9 pKi = 7.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 385 4 2 4 4.8 O=C(c1c[nH]c2cc(-c3ccccc3)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL294589 107814 0 None - 0 Guinea pig 7.9 pKi = 7.9 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 385 4 2 4 4.8 O=C(c1c[nH]c2cc(-c3ccccc3)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
14941102 20413 0 None - 0 Guinea pig 7.8 pKi = 7.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 5 1 6 4.7 O=C(C1CSC(c2cccnc2)N1)n1ccc2cc(OCc3ccccc3)ccc21 10.1021/jm00039a015
CHEMBL1194456 20413 0 None - 0 Guinea pig 7.8 pKi = 7.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 5 1 6 4.7 O=C(C1CSC(c2cccnc2)N1)n1ccc2cc(OCc3ccccc3)ccc21 10.1021/jm00039a015
CHEMBL552673 20413 0 None - 0 Guinea pig 7.8 pKi = 7.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 5 1 6 4.7 O=C(C1CSC(c2cccnc2)N1)n1ccc2cc(OCc3ccccc3)ccc21 10.1021/jm00039a015
10431642 109391 0 None - 0 Guinea pig 7.8 pKi = 7.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 409 3 2 4 4.5 O=C(c1c[nH]c2cc(C#Cc3ccccc3)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL304190 109391 0 None - 0 Guinea pig 7.8 pKi = 7.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 409 3 2 4 4.5 O=C(c1c[nH]c2cc(C#Cc3ccccc3)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
15292767 215188 0 None - 0 Guinea pig 7.8 pKi = 7.8 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 494 3 0 6 5.2 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(Br)cc21 10.1016/0960-894X(95)00509-R
CHEMBL99754 215188 0 None - 0 Guinea pig 7.8 pKi = 7.8 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 494 3 0 6 5.2 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(Br)cc21 10.1016/0960-894X(95)00509-R
10025662 210079 0 None - 0 Guinea pig 7.8 pKi = 7.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 429 6 2 5 5.0 Cc1[nH]c2cc(OCc3ccccc3)ccc2c1C(=O)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL64764 210079 0 None - 0 Guinea pig 7.8 pKi = 7.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 429 6 2 5 5.0 Cc1[nH]c2cc(OCc3ccccc3)ccc2c1C(=O)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
44304077 174609 0 None - 0 Guinea pig 7.8 pKi = 7.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 453 2 0 6 4.3 Cc1nnc2n1C1=C(C(c3ccccc3Cl)=NC2C)C2CCN(C(=O)C3CC3)CC2S1 10.1021/jm00039a015
CHEMBL430748 174609 0 None - 0 Guinea pig 7.8 pKi = 7.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 453 2 0 6 4.3 Cc1nnc2n1C1=C(C(c3ccccc3Cl)=NC2C)C2CCN(C(=O)C3CC3)CC2S1 10.1021/jm00039a015
19379103 215214 0 None - 0 Guinea pig 6.8 pKi = 6.8 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 511 7 1 6 6.1 O=C(O)CCn1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
CHEMBL99920 215214 0 None - 0 Guinea pig 6.8 pKi = 6.8 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 511 7 1 6 6.1 O=C(O)CCn1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
10453930 86484 0 None - 0 Guinea pig 5.8 pKi = 5.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 405 3 1 4 4.0 O=C(c1c[nH]c2ccccc12)[C@@H]1CS[C@H](c2cccnc2)N1C(=O)C(F)(F)F 10.1021/jm00039a015
CHEMBL2115490 86484 0 None - 0 Guinea pig 5.8 pKi = 5.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 405 3 1 4 4.0 O=C(c1c[nH]c2ccccc12)[C@@H]1CS[C@H](c2cccnc2)N1C(=O)C(F)(F)F 10.1021/jm00039a015
44330263 215046 0 None - 0 Guinea pig 7.8 pKi = 7.8 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 542 5 0 7 6.7 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(Sc3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
CHEMBL98844 215046 0 None - 0 Guinea pig 7.8 pKi = 7.8 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 542 5 0 7 6.7 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(Sc3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
15292703 215132 0 None - 0 Guinea pig 7.8 pKi = 7.8 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 522 6 0 7 6.0 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(OCc3ccccc3)cc21 10.1016/0960-894X(95)00509-R
CHEMBL99413 215132 0 None - 0 Guinea pig 7.8 pKi = 7.8 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 522 6 0 7 6.0 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(OCc3ccccc3)cc21 10.1016/0960-894X(95)00509-R
15292732 10960 0 None - 0 Guinea pig 6.8 pKi = 6.8 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 522 6 0 7 6.0 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2cccc(OCc3ccccc3)c21 10.1016/0960-894X(95)00509-R
CHEMBL100145 10960 0 None - 0 Guinea pig 6.8 pKi = 6.8 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 522 6 0 7 6.0 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2cccc(OCc3ccccc3)c21 10.1016/0960-894X(95)00509-R
11725506 107517 0 None - 0 Guinea pig 4.8 pKi = 4.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 351 3 1 4 3.4 CC(=O)N1C(c2cccnc2)SC[C@H]1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a015
CHEMBL292734 107517 0 None - 0 Guinea pig 4.8 pKi = 4.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 351 3 1 4 3.4 CC(=O)N1C(c2cccnc2)SC[C@H]1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a015
10001117 209524 0 None - 0 Guinea pig 7.8 pKi = 7.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 401 5 1 7 2.8 CCS(=O)(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL61937 209524 0 None - 0 Guinea pig 7.8 pKi = 7.8 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 401 5 1 7 2.8 CCS(=O)(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
15292702 119146 0 None - 0 Guinea pig 6.8 pKi = 6.8 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 451 6 1 5 6.0 O=C(c1ccn2c1CSC2c1cccnc1)c1c[nH]c2ccc(OCc3ccccc3)cc12 10.1016/0960-894X(95)00509-R
CHEMBL329508 119146 0 None - 0 Guinea pig 6.8 pKi = 6.8 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 451 6 1 5 6.0 O=C(c1ccn2c1CSC2c1cccnc1)c1c[nH]c2ccc(OCc3ccccc3)cc12 10.1016/0960-894X(95)00509-R
44330351 10964 0 None - 0 Guinea pig 7.7 pKi = 7.7 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 510 5 1 6 6.2 CCNC(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
CHEMBL100150 10964 0 None - 0 Guinea pig 7.7 pKi = 7.7 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 510 5 1 6 6.2 CCNC(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
10338961 169793 0 None - 0 Guinea pig 8.7 pKi = 8.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 367 3 1 7 3.2 COC(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL417563 169793 0 None - 0 Guinea pig 8.7 pKi = 8.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 367 3 1 7 3.2 COC(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
10480729 107627 0 None - 0 Guinea pig 8.7 pKi = 8.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 490 5 1 7 5.1 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(Oc3ccc(F)cc3)cc21 10.1021/jm00039a015
CHEMBL293457 107627 0 None - 0 Guinea pig 8.7 pKi = 8.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 490 5 1 7 5.1 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(Oc3ccc(F)cc3)cc21 10.1021/jm00039a015
10339741 107596 0 None - 0 Guinea pig 8.6 pKi = 8.6 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 380 5 2 6 2.4 CNC(=O)Cn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL293259 107596 0 None - 0 Guinea pig 8.6 pKi = 8.6 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 380 5 2 6 2.4 CNC(=O)Cn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
10093781 107539 0 None - 0 Guinea pig 8.6 pKi = 8.6 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 423 3 1 7 4.7 Cc1ccc2c(C(=O)[C@@H]3CSC(c4cccnc4)N3)cn(C(=O)OC(C)(C)C)c2c1 10.1021/jm00039a015
CHEMBL292860 107539 0 None - 0 Guinea pig 8.6 pKi = 8.6 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 423 3 1 7 4.7 Cc1ccc2c(C(=O)[C@@H]3CSC(c4cccnc4)N3)cn(C(=O)OC(C)(C)C)c2c1 10.1021/jm00039a015
10340397 209429 0 None - 0 Guinea pig 7.7 pKi = 7.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 391 4 1 5 4.2 O=C(c1cn(CC(F)(F)F)c2ccccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL61384 209429 0 None - 0 Guinea pig 7.7 pKi = 7.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 391 4 1 5 4.2 O=C(c1cn(CC(F)(F)F)c2ccccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
10313907 210007 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 319 3 2 4 3.1 O=C(Nc1cccc(Cl)c1)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL64462 210007 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 319 3 2 4 3.1 O=C(Nc1cccc(Cl)c1)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
10403930 209930 0 None - 0 Guinea pig 7.7 pKi = 7.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 323 3 2 4 3.5 Cc1[nH]c2ccccc2c1C(=O)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL64180 209930 0 None - 0 Guinea pig 7.7 pKi = 7.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 323 3 2 4 3.5 Cc1[nH]c2ccccc2c1C(=O)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
10088444 177399 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 337 4 1 4 3.0 O=CN1C(c2cccnc2)SC[C@H]1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a015
CHEMBL445097 177399 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 337 4 1 4 3.0 O=CN1C(c2cccnc2)SC[C@H]1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a015
10245768 209584 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 325 3 3 5 2.9 O=C(c1c[nH]c2cc(O)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL62284 209584 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 325 3 3 5 2.9 O=C(c1c[nH]c2cc(O)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
19379101 215048 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 458 3 0 7 4.2 O=C(c1ccn2c1CSC2c1cccnc1)c1cn(C(=O)N2CCOCC2)c2ccccc12 10.1016/0960-894X(95)00509-R
CHEMBL98853 215048 0 None - 0 Guinea pig 6.7 pKi = 6.7 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 458 3 0 7 4.2 O=C(c1ccn2c1CSC2c1cccnc1)c1cn(C(=O)N2CCOCC2)c2ccccc12 10.1016/0960-894X(95)00509-R
15292734 118267 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 492 4 0 6 6.1 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccccc3)cc21 10.1016/0960-894X(95)00509-R
CHEMBL327732 118267 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 492 4 0 6 6.1 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccccc3)cc21 10.1016/0960-894X(95)00509-R
44304217 20552 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 343 2 1 5 3.7 O=C(C1CSC(c2cccnc2)N1)n1ccc2ccc(Cl)cc21 10.1021/jm00039a015
CHEMBL1195426 20552 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 343 2 1 5 3.7 O=C(C1CSC(c2cccnc2)N1)n1ccc2ccc(Cl)cc21 10.1021/jm00039a015
CHEMBL554536 20552 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 343 2 1 5 3.7 O=C(C1CSC(c2cccnc2)N1)n1ccc2ccc(Cl)cc21 10.1021/jm00039a015
9999890 209676 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 381 6 2 6 3.1 O=C(O)CCn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL62725 209676 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 381 6 2 6 3.1 O=C(O)CCn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
19379096 170775 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 497 4 2 7 5.1 NNC(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
CHEMBL420826 170775 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 497 4 2 7 5.1 NNC(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
9979249 209969 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 6 2 5 4.7 O=C(c1c[nH]c2ccc(OCc3ccccc3)cc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL64285 209969 0 None - 0 Guinea pig 7.6 pKi = 7.6 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 6 2 5 4.7 O=C(c1c[nH]c2ccc(OCc3ccccc3)cc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
146417 10150 12 None - 0 Guinea pig 6.6 pKi = 6.6 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 355 3 1 4 4.6 Clc1cccc(c1)NC(=O)c1ccn2c1CSC2c1cccnc1 10.1021/jm00039a015
1839 10150 12 None - 0 Guinea pig 6.6 pKi = 6.6 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 355 3 1 4 4.6 Clc1cccc(c1)NC(=O)c1ccn2c1CSC2c1cccnc1 10.1021/jm00039a015
1858 10150 12 None - 0 Guinea pig 6.6 pKi = 6.6 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 355 3 1 4 4.6 Clc1cccc(c1)NC(=O)c1ccn2c1CSC2c1cccnc1 10.1021/jm00039a015
CHEMBL64716 10150 12 None - 0 Guinea pig 6.6 pKi = 6.6 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 355 3 1 4 4.6 Clc1cccc(c1)NC(=O)c1ccn2c1CSC2c1cccnc1 10.1021/jm00039a015
6078 7387 22 None 29 2 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 467 2 0 7 3.2 O=C(C1Cc2c(C1)c1c(s2)n2c(C)nnc2CN=C1c1ccccc1Cl)N1CCOCC1 10.1021/jm00039a015
65923 7387 22 None 29 2 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 467 2 0 7 3.2 O=C(C1Cc2c(C1)c1c(s2)n2c(C)nnc2CN=C1c1ccccc1Cl)N1CCOCC1 10.1021/jm00039a015
CHEMBL325439 7387 22 None 29 2 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 467 2 0 7 3.2 O=C(C1Cc2c(C1)c1c(s2)n2c(C)nnc2CN=C1c1ccccc1Cl)N1CCOCC1 10.1021/jm00039a015
10316889 20617 0 None - 0 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 367 5 2 6 2.7 O=C(O)Cn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL1195901 20617 0 None - 0 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 367 5 2 6 2.7 O=C(O)Cn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL555553 20617 0 None - 0 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 367 5 2 6 2.7 O=C(O)Cn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
10252852 18062 0 None - 0 Guinea pig 8.5 pKi = 8.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 443 5 1 7 4.8 O=C(c1cn(C(=O)OCc2ccccc2)c2ccccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL1179208 18062 0 None - 0 Guinea pig 8.5 pKi = 8.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 443 5 1 7 4.8 O=C(c1cn(C(=O)OCc2ccccc2)c2ccccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL64860 18062 0 None - 0 Guinea pig 8.5 pKi = 8.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 443 5 1 7 4.8 O=C(c1cn(C(=O)OCc2ccccc2)c2ccccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
10004106 207989 0 None - 0 Guinea pig 8.5 pKi = 8.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 454 7 1 8 3.2 COCCOc1ccc2c(C(=O)[C@@H]3CSC(c4cccnc4)N3)cn(C(=O)N(C)C)c2c1 10.1021/jm00039a015
CHEMBL60359 207989 0 None - 0 Guinea pig 8.5 pKi = 8.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 454 7 1 8 3.2 COCCOc1ccc2c(C(=O)[C@@H]3CSC(c4cccnc4)N3)cn(C(=O)N(C)C)c2c1 10.1021/jm00039a015
9972620 18825 0 None - 0 Guinea pig 8.5 pKi = 8.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 309 3 2 4 3.1 O=C(c1c[nH]c2ccccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL1183526 18825 0 None - 0 Guinea pig 8.5 pKi = 8.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 309 3 2 4 3.1 O=C(c1c[nH]c2ccccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL302696 18825 0 None - 0 Guinea pig 8.5 pKi = 8.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 309 3 2 4 3.1 O=C(c1c[nH]c2ccccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
10019097 209699 0 None - 0 Guinea pig 8.5 pKi = 8.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 323 3 2 4 3.5 Cc1ccc2c(C(=O)[C@@H]3CSC(c4cccnc4)N3)c[nH]c2c1 10.1021/jm00039a015
CHEMBL62815 209699 0 None - 0 Guinea pig 8.5 pKi = 8.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 323 3 2 4 3.5 Cc1ccc2c(C(=O)[C@@H]3CSC(c4cccnc4)N3)c[nH]c2c1 10.1021/jm00039a015
10478813 209895 0 None - 0 Guinea pig 8.5 pKi = 8.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 447 4 1 6 5.0 O=C(c1cn(C(=O)c2ccc(Cl)cc2)c2ccccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL64035 209895 0 None - 0 Guinea pig 8.5 pKi = 8.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 447 4 1 6 5.0 O=C(c1cn(C(=O)c2ccc(Cl)cc2)c2ccccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
10411754 210042 0 None - 0 Guinea pig 8.4 pKi = 8.4 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 456 4 1 6 4.8 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(-c3ccccc3)cc21 10.1021/jm00039a015
CHEMBL64621 210042 0 None - 0 Guinea pig 8.4 pKi = 8.4 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 456 4 1 6 4.8 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(-c3ccccc3)cc21 10.1021/jm00039a015
15759421 215037 3 None - 0 Guinea pig 8.4 pKi = 8.4 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 510 4 0 6 6.2 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
CHEMBL98813 215037 3 None - 0 Guinea pig 8.4 pKi = 8.4 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 510 4 0 6 6.2 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
44304424 20369 0 None - 0 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 309 2 1 5 3.1 O=C(C1CSC(c2cccnc2)N1)n1ccc2ccccc21 10.1021/jm00039a015
CHEMBL1194159 20369 0 None - 0 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 309 2 1 5 3.1 O=C(C1CSC(c2cccnc2)N1)n1ccc2ccccc21 10.1021/jm00039a015
CHEMBL545684 20369 0 None - 0 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 309 2 1 5 3.1 O=C(C1CSC(c2cccnc2)N1)n1ccc2ccccc21 10.1021/jm00039a015
11744076 209633 0 None - 0 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 442 4 1 6 4.7 CN(C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21)c1ccccc1 10.1021/jm00039a015
CHEMBL62530 209633 0 None - 0 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 442 4 1 6 4.7 CN(C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21)c1ccccc1 10.1021/jm00039a015
10364545 209938 0 None - 0 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 5 1 7 3.2 CC(C)S(=O)(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL64209 209938 0 None - 0 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 5 1 7 3.2 CC(C)S(=O)(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
65927 210003 26 None - 0 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 425 5 1 5 5.2 O=C(c1ccccc1)c1cccc(NC(=O)c2ccn3c2CSC3c2cccnc2)c1 10.1021/jm00039a015
CHEMBL64449 210003 26 None - 0 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 425 5 1 5 5.2 O=C(c1ccccc1)c1cccc(NC(=O)c2ccn3c2CSC3c2cccnc2)c1 10.1021/jm00039a015
44304426 19767 0 None - 0 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 343 2 1 5 3.7 O=C(C1CSC(c2cccnc2)N1)n1ccc2c(Cl)cccc21 10.1021/jm00039a015
CHEMBL1189671 19767 0 None - 0 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 343 2 1 5 3.7 O=C(C1CSC(c2cccnc2)N1)n1ccc2c(Cl)cccc21 10.1021/jm00039a015
CHEMBL539263 19767 0 None - 0 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 343 2 1 5 3.7 O=C(C1CSC(c2cccnc2)N1)n1ccc2c(Cl)cccc21 10.1021/jm00039a015
44330265 215071 0 None - 0 Guinea pig 6.5 pKi = 6.5 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 361 3 2 5 4.1 O=C(c1ccn2c1CSC2c1cccnc1)c1c[nH]c2cccc(O)c12 10.1016/0960-894X(95)00509-R
CHEMBL98999 215071 0 None - 0 Guinea pig 6.5 pKi = 6.5 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 361 3 2 5 4.1 O=C(c1ccn2c1CSC2c1cccnc1)c1c[nH]c2cccc(O)c12 10.1016/0960-894X(95)00509-R
10246465 210055 0 None - 0 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 337 3 2 4 3.8 Cc1ccc2[nH]c(C)c(C(=O)[C@@H]3CSC(c4cccnc4)N3)c2c1 10.1021/jm00039a015
CHEMBL64669 210055 0 None - 0 Guinea pig 7.5 pKi = 7.5 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 337 3 2 4 3.8 Cc1ccc2[nH]c(C)c(C(=O)[C@@H]3CSC(c4cccnc4)N3)c2c1 10.1021/jm00039a015
10366513 107489 0 None - 0 Guinea pig 7.4 pKi = 7.4 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 450 3 1 7 3.5 Cc1ccc2c(c1)c(C(=O)[C@@H]1CSC(c3cccnc3)N1)c(C)n2C(=O)N1CCOCC1 10.1021/jm00039a015
CHEMBL292550 107489 0 None - 0 Guinea pig 7.4 pKi = 7.4 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 450 3 1 7 3.5 Cc1ccc2c(c1)c(C(=O)[C@@H]1CSC(c3cccnc3)N1)c(C)n2C(=O)N1CCOCC1 10.1021/jm00039a015
10024932 108988 0 None - 0 Guinea pig 7.4 pKi = 7.4 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 416 6 2 6 4.1 O=C(c1c[nH]c2cc(OCc3cccnc3)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL302900 108988 0 None - 0 Guinea pig 7.4 pKi = 7.4 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 416 6 2 6 4.1 O=C(c1c[nH]c2cc(OCc3cccnc3)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
15292764 114691 0 None - 0 Guinea pig 7.4 pKi = 7.4 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 482 6 1 6 5.6 NCCn1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
CHEMBL319325 114691 0 None - 0 Guinea pig 7.4 pKi = 7.4 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 482 6 1 6 5.6 NCCn1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
10476962 18060 0 None - 0 Guinea pig 6.4 pKi = 6.4 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 5 1 6 4.7 O=C([C@@H]1CSC(c2cccnc2)N1)n1ccc2cccc(OCc3ccccc3)c21 10.1021/jm00039a015
CHEMBL1179198 18060 0 None - 0 Guinea pig 6.4 pKi = 6.4 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 5 1 6 4.7 O=C([C@@H]1CSC(c2cccnc2)N1)n1ccc2cccc(OCc3ccccc3)c21 10.1021/jm00039a015
CHEMBL64493 18060 0 None - 0 Guinea pig 6.4 pKi = 6.4 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 5 1 6 4.7 O=C([C@@H]1CSC(c2cccnc2)N1)n1ccc2cccc(OCc3ccccc3)c21 10.1021/jm00039a015
10339808 209728 0 None - 0 Guinea pig 8.4 pKi = 8.4 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 381 4 1 7 3.6 CCOC(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL62942 209728 0 None - 0 Guinea pig 8.4 pKi = 8.4 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 381 4 1 7 3.6 CCOC(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
10092095 210001 0 None - 0 Guinea pig 8.3 pKi = 8.3 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 395 6 1 7 3.2 COC(=O)CCn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL64445 210001 0 None - 0 Guinea pig 8.3 pKi = 8.3 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 395 6 1 7 3.2 COC(=O)CCn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
10004279 209523 0 None - 0 Guinea pig 7.4 pKi = 7.4 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 457 4 1 7 4.2 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(-c3cccnc3)cc21 10.1021/jm00039a015
CHEMBL61936 209523 0 None - 0 Guinea pig 7.4 pKi = 7.4 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 457 4 1 7 4.2 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(-c3cccnc3)cc21 10.1021/jm00039a015
10318757 109431 0 None - 0 Guinea pig 7.3 pKi = 7.3 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 399 5 1 5 4.7 O=C(c1cn(Cc2ccccc2)c2ccccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL304453 109431 0 None - 0 Guinea pig 7.3 pKi = 7.3 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 399 5 1 5 4.7 O=C(c1cn(Cc2ccccc2)c2ccccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
10338907 210010 0 None - 0 Guinea pig 8.3 pKi = 8.3 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 366 5 2 6 2.1 NC(=O)Cn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL64472 210010 0 None - 0 Guinea pig 8.3 pKi = 8.3 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 366 5 2 6 2.1 NC(=O)Cn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
19379132 215043 0 None - 0 Guinea pig 8.3 pKi = 8.3 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 483 6 1 6 5.7 O=C(c1ccn2c1CSC2c1cccnc1)c1cn(CCO)c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00509-R
CHEMBL98835 215043 0 None - 0 Guinea pig 8.3 pKi = 8.3 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 483 6 1 6 5.7 O=C(c1ccn2c1CSC2c1cccnc1)c1cn(CCO)c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00509-R
10019976 109499 0 None - 0 Guinea pig 8.3 pKi = 8.3 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 337 4 1 5 3.6 CCn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL304879 109499 0 None - 0 Guinea pig 8.3 pKi = 8.3 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 337 4 1 5 3.6 CCn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
10471661 107684 0 None - 0 Guinea pig 8.3 pKi = 8.3 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 327 3 2 4 3.3 O=C(c1c[nH]c2cc(F)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL293862 107684 0 None - 0 Guinea pig 8.3 pKi = 8.3 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 327 3 2 4 3.3 O=C(c1c[nH]c2cc(F)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
10045339 169961 0 None - 0 Guinea pig 8.2 pKi = 8.2 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 380 6 2 6 2.5 NC(=O)CCn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL418125 169961 0 None - 0 Guinea pig 8.2 pKi = 8.2 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 380 6 2 6 2.5 NC(=O)CCn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
44304089 209736 0 None - 0 Guinea pig 8.2 pKi = 8.2 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 395 6 3 6 2.3 NC(=O)NCCn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL62983 209736 0 None - 0 Guinea pig 8.2 pKi = 8.2 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 395 6 3 6 2.3 NC(=O)NCCn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
10476961 209935 0 None - 0 Guinea pig 7.3 pKi = 7.3 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 5 1 6 4.7 O=C([C@@H]1CSC(c2cccnc2)N1)n1ccc2ccc(OCc3ccccc3)cc21 10.1021/jm00039a015
CHEMBL64198 209935 0 None - 0 Guinea pig 7.3 pKi = 7.3 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 415 5 1 6 4.7 O=C([C@@H]1CSC(c2cccnc2)N1)n1ccc2ccc(OCc3ccccc3)cc21 10.1021/jm00039a015
9928151 114331 0 None - 0 Guinea pig 7.3 pKi = 7.3 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 345 3 1 4 4.4 O=C(c1ccn2c1CSC2c1cccnc1)c1c[nH]c2ccccc12 10.1016/0960-894X(95)00509-R
CHEMBL318874 114331 0 None - 0 Guinea pig 7.3 pKi = 7.3 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 345 3 1 4 4.4 O=C(c1ccn2c1CSC2c1cccnc1)c1c[nH]c2ccccc12 10.1016/0960-894X(95)00509-R
19379115 10984 0 None - 0 Guinea pig 8.2 pKi = 8.2 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 482 4 1 6 5.6 NC(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
CHEMBL100251 10984 0 None - 0 Guinea pig 8.2 pKi = 8.2 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 482 4 1 6 5.6 NC(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
10452837 108947 0 None - 0 Guinea pig 8.2 pKi = 8.2 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 387 3 2 4 3.9 O=C(c1c[nH]c2cc(Br)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
CHEMBL302683 108947 0 None - 0 Guinea pig 8.2 pKi = 8.2 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 387 3 2 4 3.9 O=C(c1c[nH]c2cc(Br)ccc12)[C@@H]1CSC(c2cccnc2)N1 10.1021/jm00039a015
11723716 209572 0 None - 0 Guinea pig 8.2 pKi = 8.2 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 323 3 2 4 3.5 Cc1cccc2c(C(=O)[C@@H]3CSC(c4cccnc4)N3)c[nH]c12 10.1021/jm00039a015
CHEMBL62219 209572 0 None - 0 Guinea pig 8.2 pKi = 8.2 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 323 3 2 4 3.5 Cc1cccc2c(C(=O)[C@@H]3CSC(c4cccnc4)N3)c[nH]c12 10.1021/jm00039a015
44303983 209933 0 None - 0 Guinea pig 6.2 pKi = 6.2 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 295 3 2 3 3.5 c1cncc(C2N[C@H](Cc3c[nH]c4ccccc34)CS2)c1 10.1021/jm00039a015
CHEMBL64194 209933 0 None - 0 Guinea pig 6.2 pKi = 6.2 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 295 3 2 3 3.5 c1cncc(C2N[C@H](Cc3c[nH]c4ccccc34)CS2)c1 10.1021/jm00039a015
15292729 215216 0 None - 0 Guinea pig 7.2 pKi = 7.2 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 451 6 1 5 6.0 O=C(c1ccn2c1CSC2c1cccnc1)c1c[nH]c2cc(OCc3ccccc3)ccc12 10.1016/0960-894X(95)00509-R
CHEMBL99928 215216 0 None - 0 Guinea pig 7.2 pKi = 7.2 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 451 6 1 5 6.0 O=C(c1ccn2c1CSC2c1cccnc1)c1c[nH]c2cc(OCc3ccccc3)ccc12 10.1016/0960-894X(95)00509-R
44330350 215162 0 None - 0 Guinea pig 8.2 pKi = 8.2 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 453 4 0 5 6.2 Cn1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
CHEMBL99583 215162 0 None - 0 Guinea pig 8.2 pKi = 8.2 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 453 4 0 5 6.2 Cn1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
129796 107232 39 None 1 2 Guinea pig 8.2 pKi = 8.2 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00039a015
CHEMBL29067 107232 39 None 1 2 Guinea pig 8.2 pKi = 8.2 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1021/jm00039a015
9865147 109063 0 None - 0 Guinea pig 8.1 pKi = 8.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 389 5 2 5 3.7 O=C(c1ccccc1)c1cccc(NC(=O)[C@@H]2CSC(c3cccnc3)N2)c1 10.1021/jm00039a015
CHEMBL303357 109063 0 None - 0 Guinea pig 8.1 pKi = 8.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 389 5 2 5 3.7 O=C(c1ccccc1)c1cccc(NC(=O)[C@@H]2CSC(c3cccnc3)N2)c1 10.1021/jm00039a015
10092032 209018 0 None - 0 Guinea pig 8.1 pKi = 8.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 394 5 1 6 2.7 CN(C)C(=O)Cn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL60996 209018 0 None - 0 Guinea pig 8.1 pKi = 8.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 394 5 1 6 2.7 CN(C)C(=O)Cn1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
10431384 86375 0 None - 0 Guinea pig 5.2 pKi = 5.2 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 405 3 1 4 4.0 O=C(c1c[nH]c2ccccc12)[C@@H]1CS[C@@H](c2cccnc2)N1C(=O)C(F)(F)F 10.1021/jm00039a015
CHEMBL2114467 86375 0 None - 0 Guinea pig 5.2 pKi = 5.2 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 405 3 1 4 4.0 O=C(c1c[nH]c2ccccc12)[C@@H]1CS[C@@H](c2cccnc2)N1C(=O)C(F)(F)F 10.1021/jm00039a015
10717912 215042 0 None - 0 Guinea pig 7.1 pKi = 7.1 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 439 4 1 4 6.2 O=C(c1ccn2c1CSC2c1cccnc1)c1c[nH]c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00509-R
CHEMBL98831 215042 0 None - 0 Guinea pig 7.1 pKi = 7.1 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 439 4 1 4 6.2 O=C(c1ccn2c1CSC2c1cccnc1)c1c[nH]c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00509-R
10365807 18044 0 None - 0 Guinea pig 7.1 pKi = 7.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 437 3 1 7 5.0 Cc1ccc2c(c1)c(C(=O)[C@@H]1CSC(c3cccnc3)N1)c(C)n2C(=O)OC(C)(C)C 10.1021/jm00039a015
CHEMBL1179109 18044 0 None - 0 Guinea pig 7.1 pKi = 7.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 437 3 1 7 5.0 Cc1ccc2c(c1)c(C(=O)[C@@H]1CSC(c3cccnc3)N1)c(C)n2C(=O)OC(C)(C)C 10.1021/jm00039a015
CHEMBL60676 18044 0 None - 0 Guinea pig 7.1 pKi = 7.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 437 3 1 7 5.0 Cc1ccc2c(c1)c(C(=O)[C@@H]1CSC(c3cccnc3)N1)c(C)n2C(=O)OC(C)(C)C 10.1021/jm00039a015
10006437 209675 0 None - 0 Guinea pig 8.1 pKi = 8.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 507 8 1 8 4.4 CCS(=O)(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(OCc3ccccc3)cc21 10.1021/jm00039a015
CHEMBL62722 209675 0 None - 0 Guinea pig 8.1 pKi = 8.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 507 8 1 8 4.4 CCS(=O)(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(OCc3ccccc3)cc21 10.1021/jm00039a015
10478363 19202 0 None - 0 Guinea pig 8.1 pKi = 8.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 439 4 1 8 4.4 COc1ccc2c(C(=O)[C@@H]3CSC(c4cccnc4)N3)cn(C(=O)OC(C)(C)C)c2c1 10.1021/jm00039a015
CHEMBL1185934 19202 0 None - 0 Guinea pig 8.1 pKi = 8.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 439 4 1 8 4.4 COc1ccc2c(C(=O)[C@@H]3CSC(c4cccnc4)N3)cn(C(=O)OC(C)(C)C)c2c1 10.1021/jm00039a015
CHEMBL442170 19202 0 None - 0 Guinea pig 8.1 pKi = 8.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 439 4 1 8 4.4 COc1ccc2c(C(=O)[C@@H]3CSC(c4cccnc4)N3)cn(C(=O)OC(C)(C)C)c2c1 10.1021/jm00039a015
10475683 208203 0 None - 0 Guinea pig 8.1 pKi = 8.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 393 3 1 6 4.3 CC(C)(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL60477 208203 0 None - 0 Guinea pig 8.1 pKi = 8.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 393 3 1 6 4.3 CC(C)(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
10409191 209894 0 None - 0 Guinea pig 8.1 pKi = 8.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 408 3 2 6 4.0 CC(C)(C)NC(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
CHEMBL64034 209894 0 None - 0 Guinea pig 8.1 pKi = 8.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 408 3 2 6 4.0 CC(C)(C)NC(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc21 10.1021/jm00039a015
10474251 107654 0 None - 0 Guinea pig 7.1 pKi = 7.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 369 5 2 6 3.2 COc1cc2[nH]cc(C(=O)[C@@H]3CSC(c4cccnc4)N3)c2cc1OC 10.1021/jm00039a015
CHEMBL293653 107654 0 None - 0 Guinea pig 7.1 pKi = 7.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 369 5 2 6 3.2 COc1cc2[nH]cc(C(=O)[C@@H]3CSC(c4cccnc4)N3)c2cc1OC 10.1021/jm00039a015
10342990 107695 0 None - 0 Guinea pig 7.1 pKi = 7.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 436 3 1 7 3.2 Cc1c(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc2n1C(=O)N1CCOCC1 10.1021/jm00039a015
CHEMBL293916 107695 0 None - 0 Guinea pig 7.1 pKi = 7.1 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 436 3 1 7 3.2 Cc1c(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc2n1C(=O)N1CCOCC1 10.1021/jm00039a015
15292718 10995 0 None - 0 Guinea pig 7.1 pKi = 7.1 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 450 3 0 6 5.0 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(Cl)cc21 10.1016/0960-894X(95)00509-R
CHEMBL100321 10995 0 None - 0 Guinea pig 7.1 pKi = 7.1 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 450 3 0 6 5.0 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(Cl)cc21 10.1016/0960-894X(95)00509-R
10457611 107650 0 None - 0 Guinea pig 8.0 pKi = 8.0 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 474 4 1 6 5.0 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(-c3ccc(F)cc3)cc21 10.1021/jm00039a015
CHEMBL293642 107650 0 None - 0 Guinea pig 8.0 pKi = 8.0 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 474 4 1 6 5.0 CN(C)C(=O)n1cc(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccc(-c3ccc(F)cc3)cc21 10.1021/jm00039a015
10025326 18063 0 None - 0 Guinea pig 8.0 pKi = 8.0 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 423 3 1 7 4.7 Cc1c(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc2n1C(=O)OC(C)(C)C 10.1021/jm00039a015
CHEMBL1179209 18063 0 None - 0 Guinea pig 8.0 pKi = 8.0 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 423 3 1 7 4.7 Cc1c(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc2n1C(=O)OC(C)(C)C 10.1021/jm00039a015
CHEMBL64882 18063 0 None - 0 Guinea pig 8.0 pKi = 8.0 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 423 3 1 7 4.7 Cc1c(C(=O)[C@@H]2CSC(c3cccnc3)N2)c2ccccc2n1C(=O)OC(C)(C)C 10.1021/jm00039a015
11724774 209914 0 None - 0 Guinea pig 8.0 pKi = 8.0 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 339 4 2 5 3.2 COc1ccc2c(C(=O)[C@@H]3CSC(c4cccnc4)N3)c[nH]c2c1 10.1021/jm00039a015
CHEMBL64125 209914 0 None - 0 Guinea pig 8.0 pKi = 8.0 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 339 4 2 5 3.2 COc1ccc2c(C(=O)[C@@H]3CSC(c4cccnc4)N3)c[nH]c2c1 10.1021/jm00039a015
15292730 114191 0 None - 0 Guinea pig 7.1 pKi = 7.1 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 451 6 1 5 6.0 O=C(c1ccn2c1CSC2c1cccnc1)c1c[nH]c2c(OCc3ccccc3)cccc12 10.1016/0960-894X(95)00509-R
CHEMBL318044 114191 0 None - 0 Guinea pig 7.1 pKi = 7.1 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 451 6 1 5 6.0 O=C(c1ccn2c1CSC2c1cccnc1)c1c[nH]c2c(OCc3ccccc3)cccc12 10.1016/0960-894X(95)00509-R
15292716 11238 0 None - 0 Guinea pig 6.0 pKi = 6.0 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 546 6 0 7 5.3 CN(C)S(=O)(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
CHEMBL101760 11238 0 None - 0 Guinea pig 6.0 pKi = 6.0 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 546 6 0 7 5.3 CN(C)S(=O)(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00509-R
10341665 107508 0 None - 0 Guinea pig 7.0 pKi = 7.0 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 413 4 1 6 4.3 O=C(c1ccccc1)c1ccc2ccn(C(=O)[C@@H]3CSC(c4cccnc4)N3)c2c1 10.1021/jm00039a015
CHEMBL292704 107508 0 None - 0 Guinea pig 7.0 pKi = 7.0 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 413 4 1 6 4.3 O=C(c1ccccc1)c1ccc2ccn(C(=O)[C@@H]3CSC(c4cccnc4)N3)c2c1 10.1021/jm00039a015
15292701 114065 0 None - 0 Guinea pig 7.0 pKi = 7.0 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 416 3 0 6 4.4 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccccc21 10.1016/0960-894X(95)00509-R
CHEMBL317119 114065 0 None - 0 Guinea pig 7.0 pKi = 7.0 Functional
Tested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptorsTested in vitro for antagonistic activity to displace [3H]PAF from rabbit platelet membrane PAF receptors
ChEMBL 416 3 0 6 4.4 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CSC3c2cccnc2)c2ccccc21 10.1016/0960-894X(95)00509-R
10409251 209613 0 None - 0 Guinea pig 5.0 pKi = 5.0 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 409 3 1 5 4.8 CC(C)(C)OC(=O)N1C(c2cccnc2)SC[C@H]1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a015
CHEMBL62424 209613 0 None - 0 Guinea pig 5.0 pKi = 5.0 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 409 3 1 5 4.8 CC(C)(C)OC(=O)N1C(c2cccnc2)SC[C@H]1C(=O)c1c[nH]c2ccccc12 10.1021/jm00039a015
1859 7223 62 None -1 2 Guinea pig 7.0 pKi = 7.0 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00039a015
1860 7223 62 None -1 2 Guinea pig 7.0 pKi = 7.0 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00039a015
65889 7223 62 None -1 2 Guinea pig 7.0 pKi = 7.0 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00039a015
CHEMBL280164 7223 62 None -1 2 Guinea pig 7.0 pKi = 7.0 Functional
Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandAntagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligand
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00039a015
4698 9788 0 None - 1 Human 7.4 pA2 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 361 6 1 6 3.3 COC(=O)C1=C(C)NC(=C(C1C)C(=O)OCCSc1ccccc1)C 2170626
6080 9788 0 None - 1 Human 7.4 pA2 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 361 6 1 6 3.3 COC(=O)C1=C(C)NC(=C(C1C)C(=O)OCCSc1ccccc1)C 2170626
CHEMBL1395565 9788 0 None - 1 Human 7.4 pA2 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 361 6 1 6 3.3 COC(=O)C1=C(C)NC(=C(C1C)C(=O)OCCSc1ccccc1)C 2170626
10103 10189 72 None -28 2 Human 8.3 pIC50 = 8.3 Functional
Inhibitory concentration against platelet activating factor receptorInhibitory concentration against platelet activating factor receptor
Drug Central 415 2 0 3 5.6 Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 None
133017 10189 72 None -28 2 Human 8.3 pIC50 = 8.3 Functional
Inhibitory concentration against platelet activating factor receptorInhibitory concentration against platelet activating factor receptor
Drug Central 415 2 0 3 5.6 Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 None
2413 10189 72 None -28 2 Human 8.3 pIC50 = 8.3 Functional
Inhibitory concentration against platelet activating factor receptorInhibitory concentration against platelet activating factor receptor
Drug Central 415 2 0 3 5.6 Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 None
CHEMBL91397 10189 72 None -28 2 Human 8.3 pIC50 = 8.3 Functional
Inhibitory concentration against platelet activating factor receptorInhibitory concentration against platelet activating factor receptor
Drug Central 415 2 0 3 5.6 Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 None
DB11614 10189 72 None -28 2 Human 8.3 pIC50 = 8.3 Functional
Inhibitory concentration against platelet activating factor receptorInhibitory concentration against platelet activating factor receptor
Drug Central 415 2 0 3 5.6 Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 None
6078 7387 22 None -29 2 Human 5.1 pIC50 = 5.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 467 2 0 7 3.2 O=C(C1Cc2c(C1)c1c(s2)n2c(C)nnc2CN=C1c1ccccc1Cl)N1CCOCC1 2170626
65923 7387 22 None -29 2 Human 5.1 pIC50 = 5.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 467 2 0 7 3.2 O=C(C1Cc2c(C1)c1c(s2)n2c(C)nnc2CN=C1c1ccccc1Cl)N1CCOCC1 2170626
CHEMBL325439 7387 22 None -29 2 Human 5.1 pIC50 = 5.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 467 2 0 7 3.2 O=C(C1Cc2c(C1)c1c(s2)n2c(C)nnc2CN=C1c1ccccc1Cl)N1CCOCC1 2170626
4698 9788 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 361 6 1 6 3.3 COC(=O)C1=C(C)NC(=C(C1C)C(=O)OCCSc1ccccc1)C 2170626
6080 9788 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 361 6 1 6 3.3 COC(=O)C1=C(C)NC(=C(C1C)C(=O)OCCSc1ccccc1)C 2170626
CHEMBL1395565 9788 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 361 6 1 6 3.3 COC(=O)C1=C(C)NC(=C(C1C)C(=O)OCCSc1ccccc1)C 2170626
6078 7387 22 None -29 2 Human 6.3 pIC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 467 2 0 7 3.2 O=C(C1Cc2c(C1)c1c(s2)n2c(C)nnc2CN=C1c1ccccc1Cl)N1CCOCC1 2262914
65923 7387 22 None -29 2 Human 6.3 pIC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 467 2 0 7 3.2 O=C(C1Cc2c(C1)c1c(s2)n2c(C)nnc2CN=C1c1ccccc1Cl)N1CCOCC1 2262914
CHEMBL325439 7387 22 None -29 2 Human 6.3 pIC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 467 2 0 7 3.2 O=C(C1Cc2c(C1)c1c(s2)n2c(C)nnc2CN=C1c1ccccc1Cl)N1CCOCC1 2262914
107681 8004 29 None 45 2 Human 6.8 pIC50 = 6.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 592 27 1 8 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)(OCC[n+]1ccsc1)[O-])OC 2986648
6079 8004 29 None 45 2 Human 6.8 pIC50 = 6.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 592 27 1 8 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)(OCC[n+]1ccsc1)[O-])OC 2986648
CHEMBL295212 8004 29 None 45 2 Human 6.8 pIC50 = 6.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 592 27 1 8 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)(OCC[n+]1ccsc1)[O-])OC 2986648
107757 8005 3 None 4 2 Human 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 15922596
107757 8005 3 None 4 2 Human 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 1657923
1852 8005 3 None 4 2 Human 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 15922596
1852 8005 3 None 4 2 Human 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 1657923
CHEMBL1180101 8005 3 None 4 2 Human 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 15922596
CHEMBL1180101 8005 3 None 4 2 Human 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 1657923
108156 9767 52 None - 1 Human 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 7594622
1831 9767 52 None - 1 Human 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 7594622
1833 9767 52 None - 1 Human 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 7594622
CHEMBL1235246 9767 52 None - 1 Human 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 7594622
DB02261 9767 52 None - 1 Human 8.2 pIC50 = 8.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 7594622
1834 8339 0 None - 1 Human 5.0 pIC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOCC(OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 7594622
2499 8339 0 None - 1 Human 5.0 pIC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOCC(OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 7594622
CHEMBL17935 8339 0 None - 1 Human 5.0 pIC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOCC(OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 7594622
132181 6860 0 None - 1 Human 5.8 pIC50 None 5.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 565 27 0 7 6.7 CCCCCCCCCCCCCCCCC(COCC(OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-])C 7594622
1830 6860 0 None - 1 Human 5.8 pIC50 None 5.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 565 27 0 7 6.7 CCCCCCCCCCCCCCCCC(COCC(OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-])C 7594622
1853 10324 38 None -6 2 Human 6.2 pIC50 None 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 352 0 0 2 4.3 Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 10465415
60680 10324 38 None -6 2 Human 6.2 pIC50 None 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 352 0 0 2 4.3 Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 10465415
CHEMBL10971 10324 38 None -6 2 Human 6.2 pIC50 None 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 352 0 0 2 4.3 Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 10465415
1854 10325 7 None - 1 Human 6.2 pIC50 None 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 355 1 0 3 3.1 Clc1ccc2c(c1)CCc1c(C2N2CCN(CC2)C(=O)C)nccc1 10465415
9950564 10325 7 None - 1 Human 6.2 pIC50 None 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 355 1 0 3 3.1 Clc1ccc2c(c1)CCc1c(C2N2CCN(CC2)C(=O)C)nccc1 10465415
CHEMBL326821 10325 7 None - 1 Human 6.2 pIC50 None 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 355 1 0 3 3.1 Clc1ccc2c(c1)CCc1c(C2N2CCN(CC2)C(=O)C)nccc1 10465415
159547 10342 19 None - 1 Human 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 440 7 0 5 5.1 COc1cc(CCc2ccc(cc2)c2cc3ccccc3c3=NCCn23)cc(c1OC)OC 3183958
1855 10342 19 None - 1 Human 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 440 7 0 5 5.1 COc1cc(CCc2ccc(cc2)c2cc3ccccc3c3=NCCn23)cc(c1OC)OC 3183958
CHEMBL449395 10342 19 None - 1 Human 7.2 pIC50 None 7.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 440 7 0 5 5.1 COc1cc(CCc2ccc(cc2)c2cc3ccccc3c3=NCCn23)cc(c1OC)OC 3183958
1829 6859 0 None - 1 Human 7.7 pIC50 None 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 510 26 1 5 6.7 CCCCCCCCCCCCCCCCOCC(COP(=O)(OCC[N+](C)(C)C)O)OCC 7594622
9546625 6859 0 None - 1 Human 7.7 pIC50 None 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 510 26 1 5 6.7 CCCCCCCCCCCCCCCCOCC(COP(=O)(OCC[N+](C)(C)C)O)OCC 7594622
119175 8879 0 None - 1 Human 9.0 pIC50 None 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 488 6 0 5 7.2 CC(Cc1ccc(cc1)CCc1sc2c(c1)C(=NC(c1n2c(C)nn1)C)c1ccccc1Cl)C 1657923
1857 8879 0 None - 1 Human 9.0 pIC50 None 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 488 6 0 5 7.2 CC(Cc1ccc(cc1)CCc1sc2c(c1)C(=NC(c1n2c(C)nn1)C)c1ccccc1Cl)C 1657923
CHEMBL2107428 8879 0 None - 1 Human 9.0 pIC50 None 9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 488 6 0 5 7.2 CC(Cc1ccc(cc1)CCc1sc2c(c1)C(=NC(c1n2c(C)nn1)C)c1ccccc1Cl)C 1657923




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DOI

460131 104081 4 None - 0 Guinea pig 6.8 pEC50 = 6.8 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 631 13 1 10 3.9 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)NC(C)CC(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL269132 104081 4 None - 0 Guinea pig 6.8 pEC50 = 6.8 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 631 13 1 10 3.9 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)NC(C)CC(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
6324617 196342 27 None - 1 Guinea pig 6.8 pEC50 = 6.8 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 424 0 3 10 -1.4 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6O)O[C@@]4(C(=O)O5)[C@@]12O 10.1021/jm00060a006
CHEMBL514432 196342 27 None - 1 Guinea pig 6.8 pEC50 = 6.8 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 424 0 3 10 -1.4 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6O)O[C@@]4(C(=O)O5)[C@@]12O 10.1021/jm00060a006
3075901 209668 4 None - 0 Guinea pig 6.7 pEC50 = 6.7 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 602 13 0 10 3.7 CCC(CC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL6270 209668 4 None - 0 Guinea pig 6.7 pEC50 = 6.7 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 602 13 0 10 3.7 CCC(CC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
3075901 209668 4 None - 0 Guinea pig 6.6 pEC50 = 6.6 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 602 13 0 10 3.7 CCC(CC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL6270 209668 4 None - 0 Guinea pig 6.6 pEC50 = 6.6 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 602 13 0 10 3.7 CCC(CC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
131088 104003 5 None - 0 Guinea pig 6.5 pEC50 = 6.5 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 588 10 0 10 3.3 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)C(C)(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL268596 104003 5 None - 0 Guinea pig 6.5 pEC50 = 6.5 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 588 10 0 10 3.3 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)C(C)(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
3075903 209567 7 None - 0 Guinea pig 6.4 pEC50 = 6.4 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 546 10 0 10 2.3 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(C)=O)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL6217 209567 7 None - 0 Guinea pig 6.4 pEC50 = 6.4 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 546 10 0 10 2.3 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(C)=O)C2)cc(OC)c1OC 10.1021/jm00060a006
131088 104003 5 None - 0 Guinea pig 6.4 pEC50 = 6.4 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 588 10 0 10 3.3 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)C(C)(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL268596 104003 5 None - 0 Guinea pig 6.4 pEC50 = 6.4 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 588 10 0 10 3.3 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)C(C)(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
3075899 209540 4 None - 0 Guinea pig 6.4 pEC50 = 6.4 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 642 11 0 10 4.2 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)c3ccccc3Cl)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL6203 209540 4 None - 0 Guinea pig 6.4 pEC50 = 6.4 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 642 11 0 10 4.2 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)c3ccccc3Cl)C2)cc(OC)c1OC 10.1021/jm00060a006
3075899 209540 4 None - 0 Guinea pig 7.3 pEC50 = 7.3 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 642 11 0 10 4.2 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)c3ccccc3Cl)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL6203 209540 4 None - 0 Guinea pig 7.3 pEC50 = 7.3 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 642 11 0 10 4.2 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)c3ccccc3Cl)C2)cc(OC)c1OC 10.1021/jm00060a006
3075899 209540 4 None - 0 Guinea pig 6.2 pEC50 = 6.2 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 642 11 0 10 4.2 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)c3ccccc3Cl)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL6203 209540 4 None - 0 Guinea pig 6.2 pEC50 = 6.2 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 642 11 0 10 4.2 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)c3ccccc3Cl)C2)cc(OC)c1OC 10.1021/jm00060a006
457910 104080 1 None - 0 Guinea pig 6.2 pEC50 = 6.2 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 631 14 0 10 4.0 CCCN(CCC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL269131 104080 1 None - 0 Guinea pig 6.2 pEC50 = 6.2 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 631 14 0 10 4.0 CCCN(CCC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
10077575 102441 0 None - 0 Guinea pig 7.2 pEC50 = 7.2 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 617 12 1 10 3.5 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)NC(C)C(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
CHEMBL258053 102441 0 None - 0 Guinea pig 7.2 pEC50 = 7.2 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 617 12 1 10 3.5 COc1cc(C(=O)N2CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C(COC(=O)NC(C)C(C)C)C2)cc(OC)c1OC 10.1021/jm00060a006
3013157 104111 3 None - 0 Guinea pig 6.2 pEC50 = 6.2 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 603 13 1 10 3.2 CCCCNC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL269340 104111 3 None - 0 Guinea pig 6.2 pEC50 = 6.2 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 603 13 1 10 3.2 CCCCNC(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
3075901 209668 4 None - 0 Guinea pig 7.1 pEC50 = 7.1 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 602 13 0 10 3.7 CCC(CC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
CHEMBL6270 209668 4 None - 0 Guinea pig 7.1 pEC50 = 7.1 Binding
Inhibition of [3H]PAF binding to rabbit platelet membraneInhibition of [3H]PAF binding to rabbit platelet membrane
ChEMBL 602 13 0 10 3.7 CCC(CC)C(=O)OCC1CN(C(=O)c2cc(OC)c(OC)c(OC)c2)CCN1C(=O)c1cc(OC)c(OC)c(OC)c1 10.1021/jm00060a006
9954410 56969 1 None - 0 Human 10.8 pIC50 = 10.8 Binding
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
ChEMBL 430 10 1 6 3.5 CCOC[C@H](CC(C)C)NS(=O)(=O)c1ccc(Cn2c(C)nc3cnccc32)cc1 10.1016/S0960-894X(01)81205-1
CHEMBL157078 56969 1 None - 0 Human 10.8 pIC50 = 10.8 Binding
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
ChEMBL 430 10 1 6 3.5 CCOC[C@H](CC(C)C)NS(=O)(=O)c1ccc(Cn2c(C)nc3cnccc32)cc1 10.1016/S0960-894X(01)81205-1
14851874 105489 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 497 2 0 6 5.0 Cc1nnc2n1-c1sc(C#CCN3C(=O)CCc4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL277701 105489 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 497 2 0 6 5.0 Cc1nnc2n1-c1sc(C#CCN3C(=O)CCc4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
108156 9767 52 None - 1 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrsDisplacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrs
ChEMBL 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 10.1016/j.bmcl.2013.01.025
1831 9767 52 None - 1 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrsDisplacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrs
ChEMBL 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 10.1016/j.bmcl.2013.01.025
1833 9767 52 None - 1 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrsDisplacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrs
ChEMBL 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 10.1016/j.bmcl.2013.01.025
CHEMBL1235246 9767 52 None - 1 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrsDisplacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrs
ChEMBL 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 10.1016/j.bmcl.2013.01.025
DB02261 9767 52 None - 1 Human 9.6 pIC50 = 9.6 Binding
Displacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrsDisplacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrs
ChEMBL 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 10.1016/j.bmcl.2013.01.025
14851876 80686 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 498 2 0 8 4.3 Cc1nnc2n1-c1sc(C#CCn3c(=O)n(C)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20195 80686 0 None - 0 Human 9.5 pIC50 = 9.5 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 498 2 0 8 4.3 Cc1nnc2n1-c1sc(C#CCn3c(=O)n(C)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14851882 78449 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 526 2 0 9 3.7 Cc1nnc2n1-c1sc(C#CCn3c(=O)n(C)c(=O)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL19640 78449 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 526 2 0 9 3.7 Cc1nnc2n1-c1sc(C#CCn3c(=O)n(C)c(=O)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14851869 78785 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 499 2 0 7 4.4 Cc1nnc2n1-c1sc(C#CCN3C(=O)COc4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL19747 78785 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 499 2 0 7 4.4 Cc1nnc2n1-c1sc(C#CCN3C(=O)COc4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14851877 79611 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 523 2 1 6 5.6 Cc1nnc2n1-c1sc(C#CCC34CCCc5cccc(c53)NC4=O)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20019 79611 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 523 2 1 6 5.6 Cc1nnc2n1-c1sc(C#CCC34CCCc5cccc(c53)NC4=O)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
44297792 107671 0 None - 1 Human 9.0 pIC50 = 9 Binding
Compound was evaluated for inhibitory activity of binding of [3H]-C18 PAF to human platelet membrane Platelet activating factor receptorCompound was evaluated for inhibitory activity of binding of [3H]-C18 PAF to human platelet membrane Platelet activating factor receptor
ChEMBL 634 14 0 10 5.4 CCCS(=O)(=O)c1cc(C2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCS(=O)(=O)c1ccccc1 10.1016/S0960-894X(01)80446-7
CHEMBL293773 107671 0 None - 1 Human 9.0 pIC50 = 9 Binding
Compound was evaluated for inhibitory activity of binding of [3H]-C18 PAF to human platelet membrane Platelet activating factor receptorCompound was evaluated for inhibitory activity of binding of [3H]-C18 PAF to human platelet membrane Platelet activating factor receptor
ChEMBL 634 14 0 10 5.4 CCCS(=O)(=O)c1cc(C2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCS(=O)(=O)c1ccccc1 10.1016/S0960-894X(01)80446-7
10002808 215112 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 430 11 1 3 6.1 CCCCc1c(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)cc(OC)c2ccccc12 10.1021/jm00172a029
CHEMBL99294 215112 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 430 11 1 3 6.1 CCCCc1c(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)cc(OC)c2ccccc12 10.1021/jm00172a029
14851887 106027 0 None - 0 Human 9.0 pIC50 = 9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 560 3 0 8 5.8 Cc1nnc2n1-c1sc(C#CCn3c(=O)n(-c4ccccc4)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL281779 106027 0 None - 0 Human 9.0 pIC50 = 9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 560 3 0 8 5.8 Cc1nnc2n1-c1sc(C#CCn3c(=O)n(-c4ccccc4)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14851886 106204 0 None - 0 Human 9.0 pIC50 = 9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 495 2 0 7 5.0 Cc1nnc2n1-c1sc(C#CCn3ccc4ccccc4c3=O)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL282883 106204 0 None - 0 Human 9.0 pIC50 = 9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 495 2 0 7 5.0 Cc1nnc2n1-c1sc(C#CCn3ccc4ccccc4c3=O)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14851865 106253 0 None - 0 Human 9.0 pIC50 = 9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 468 2 0 7 5.0 Cc1nnc2n1-c1sc(C#CCn3ncc4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL283162 106253 0 None - 0 Human 9.0 pIC50 = 9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 468 2 0 7 5.0 Cc1nnc2n1-c1sc(C#CCn3ncc4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
6918268 86276 11 None - 0 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 632 13 2 9 6.7 COc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(CNC(=O)N(C)O)c1OCCSc1ccc(Cl)cc1 10.1021/jm980046r
CHEMBL2113720 86276 11 None - 0 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 632 13 2 9 6.7 COc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(CNC(=O)N(C)O)c1OCCSc1ccc(Cl)cc1 10.1021/jm980046r
9824829 115492 0 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 446 7 0 6 5.1 COc1cc(CCc2ccc(C3=Cc4ccsc4C4=NCCN34)cc2)cc(OC)c1OC 10.1021/jm00073a008
CHEMBL320835 115492 0 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 446 7 0 6 5.1 COc1cc(CCc2ccc(C3=Cc4ccsc4C4=NCCN34)cc2)cc(OC)c1OC 10.1021/jm00073a008
14851902 106701 0 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 338 1 0 5 3.6 C#Cc1cc2c(s1)-n1c(C)nnc1CN=C2c1ccccc1Cl 10.1021/jm00108a031
CHEMBL286217 106701 0 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 338 1 0 5 3.6 C#Cc1cc2c(s1)-n1c(C)nnc1CN=C2c1ccccc1Cl 10.1021/jm00108a031
44281337 174628 0 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 472 6 0 5 7.2 CCCCc1ccc(/C=C\c2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)cc1 10.1021/jm00108a031
CHEMBL430919 174628 0 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 472 6 0 5 7.2 CCCCc1ccc(/C=C\c2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)cc1 10.1021/jm00108a031
10624368 176177 0 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 474 7 0 5 6.8 CCCCc1ccc(CCc2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)cc1 10.1021/jm00108a031
CHEMBL442259 176177 0 None - 0 Human 8.0 pIC50 = 8 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 474 7 0 5 6.8 CCCCc1ccc(CCc2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)cc1 10.1021/jm00108a031
44284550 143224 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 415 6 0 5 4.8 Cc1nc2cnccc2n1CCCOC1CCC(c2ccc(Br)cc2)O1 10.1016/S0960-894X(00)80006-2
CHEMBL37357 143224 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 415 6 0 5 4.8 Cc1nc2cnccc2n1CCCOC1CCC(c2ccc(Br)cc2)O1 10.1016/S0960-894X(00)80006-2
14347400 174745 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 420 13 1 3 6.1 CCCCC/C(=C/C=C/C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1021/jm00128a026
CHEMBL431744 174745 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 420 13 1 3 6.1 CCCCC/C(=C/C=C/C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1021/jm00128a026
14347434 201347 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 462 8 1 4 6.4 COc1ccc(C(=C/C=C/C(=O)Nc2ccc(-c3cccnc3)cc2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
CHEMBL53014 201347 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 462 8 1 4 6.4 COc1ccc(C(=C/C=C/C(=O)Nc2ccc(-c3cccnc3)cc2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
14851836 78961 0 None - 0 Human 8.0 pIC50 = 8 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 475 2 0 6 3.7 Cc1nnc2n1-c1ccc(C#CCN3C(=O)c4ccccc4C3=O)cc1C(c1ccccc1F)=NC2 10.1021/jm00107a048
CHEMBL19801 78961 0 None - 0 Human 8.0 pIC50 = 8 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 475 2 0 6 3.7 Cc1nnc2n1-c1ccc(C#CCN3C(=O)c4ccccc4C3=O)cc1C(c1ccccc1F)=NC2 10.1021/jm00107a048
13557499 42329 0 None - 0 Human 7.0 pIC50 = 7 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 401 6 1 6 3.0 Cc1cc2nc3ccc(C(=O)NCCCCc4cncnc4)cn3c(=O)c2cc1C 10.1021/jm00397a034
CHEMBL143914 42329 0 None - 0 Human 7.0 pIC50 = 7 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 401 6 1 6 3.0 Cc1cc2nc3ccc(C(=O)NCCCCc4cncnc4)cn3c(=O)c2cc1C 10.1021/jm00397a034
14851906 106957 0 None - 0 Human 7.0 pIC50 = 7 Binding
Compound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog plateletsCompound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets
ChEMBL 414 1 0 5 5.0 Cc1nnc2n1-c1sc(C#Cc3ccccc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL288098 106957 0 None - 0 Human 7.0 pIC50 = 7 Binding
Compound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog plateletsCompound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets
ChEMBL 414 1 0 5 5.0 Cc1nnc2n1-c1sc(C#Cc3ccccc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
15084147 119877 0 None - 0 Human 7.0 pIC50 = 7 Binding
Compound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog plateletsCompound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets
ChEMBL 470 3 0 5 6.2 Cc1nnc2n1-c1sc(C#Cc3ccc(CC(C)C)cc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL33139 119877 0 None - 0 Human 7.0 pIC50 = 7 Binding
Compound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog plateletsCompound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets
ChEMBL 470 3 0 5 6.2 Cc1nnc2n1-c1sc(C#Cc3ccc(CC(C)C)cc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
44386405 138320 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 484 5 0 7 5.6 Cc1nnc2n1-c1sc(CCc3ccc(-n4ccnc4)cc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL369194 138320 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 484 5 0 7 5.6 Cc1nnc2n1-c1sc(CCc3ccc(-n4ccnc4)cc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
44283802 145574 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 373 9 0 6 3.9 COc1cc([C@H]2CC[C@@H](OCCCc3cccnc3)O2)cc(OC)c1OC 10.1016/S0960-894X(00)80005-0
CHEMBL37809 145574 0 None - 0 Human 7.0 pIC50 = 7 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 373 9 0 6 3.9 COc1cc([C@H]2CC[C@@H](OCCCc3cccnc3)O2)cc(OC)c1OC 10.1016/S0960-894X(00)80005-0
14547304 108622 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 384 15 1 2 6.6 CCCCCC(=C/C=C/C(=O)N[C@H](C)CCCc1cccnc1)CCCCC 10.1021/jm00128a026
CHEMBL300463 108622 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 384 15 1 2 6.6 CCCCCC(=C/C=C/C(=O)N[C@H](C)CCCc1cccnc1)CCCCC 10.1021/jm00128a026
44284467 130648 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 373 9 0 6 3.9 COc1cc([C@@H]2CC[C@H](OCCCc3cccnc3)O2)cc(OC)c1OC 10.1016/S0960-894X(00)80006-2
CHEMBL36269 130648 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 373 9 0 6 3.9 COc1cc([C@@H]2CC[C@H](OCCCc3cccnc3)O2)cc(OC)c1OC 10.1016/S0960-894X(00)80006-2
14547223 200923 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 384 10 1 2 5.4 O=C(CCC=C(c1ccccc1)c1ccccc1)NCCCCc1cccnc1 10.1021/jm00128a026
CHEMBL52821 200923 0 None - 0 Human 7.0 pIC50 = 7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 384 10 1 2 5.4 O=C(CCC=C(c1ccccc1)c1ccccc1)NCCCCc1cccnc1 10.1021/jm00128a026
122159 108131 19 None - 0 Guinea pig 7.0 pIC50 = 7 Binding
Inhibitor concentration required to block 50% of the specific [3H]PAF binding, obtained as natural product.Inhibitor concentration required to block 50% of the specific [3H]PAF binding, obtained as natural product.
ChEMBL 356 6 0 5 3.8 C=CCC1=C[C@@]2(OC)C(=CC1=O)O[C@H](c1ccc(OC)c(OC)c1)[C@H]2C 10.1021/jm00384a023
CHEMBL296958 108131 19 None - 0 Guinea pig 7.0 pIC50 = 7 Binding
Inhibitor concentration required to block 50% of the specific [3H]PAF binding, obtained as natural product.Inhibitor concentration required to block 50% of the specific [3H]PAF binding, obtained as natural product.
ChEMBL 356 6 0 5 3.8 C=CCC1=C[C@@]2(OC)C(=CC1=O)O[C@H](c1ccc(OC)c(OC)c1)[C@H]2C 10.1021/jm00384a023
14851922 80148 0 None - 0 Human 7.0 pIC50 = 7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 505 3 0 6 4.5 COC1N=C(c2ccccc2F)c2cc(C#CCN3C(=O)CCc4ccccc43)ccc2-n2c(C)nnc21 10.1021/jm00107a048
CHEMBL20141 80148 0 None - 0 Human 7.0 pIC50 = 7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 505 3 0 6 4.5 COC1N=C(c2ccccc2F)c2cc(C#CCN3C(=O)CCc4ccccc43)ccc2-n2c(C)nnc21 10.1021/jm00107a048
14851932 83121 0 None - 0 Human 7.0 pIC50 = 7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 491 2 0 5 4.9 Cc1nnc2n1-c1ccc(C#CCN3C(=O)CCc4ccccc43)cc1C(c1ccc(Cl)cc1)=NC2 10.1021/jm00107a048
CHEMBL20591 83121 0 None - 0 Human 7.0 pIC50 = 7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 491 2 0 5 4.9 Cc1nnc2n1-c1ccc(C#CCN3C(=O)CCc4ccccc43)cc1C(c1ccc(Cl)cc1)=NC2 10.1021/jm00107a048
14851895 106251 0 None - 0 Human 7.0 pIC50 = 7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 489 3 0 6 4.0 CCc1nnc2n1-c1ccc(C#CCN3C(=O)c4ccccc4C3=O)cc1C(c1ccccc1F)=NC2 10.1021/jm00107a048
CHEMBL283152 106251 0 None - 0 Human 7.0 pIC50 = 7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 489 3 0 6 4.0 CCc1nnc2n1-c1ccc(C#CCN3C(=O)c4ccccc4C3=O)cc1C(c1ccccc1F)=NC2 10.1021/jm00107a048
13557473 107609 0 None - 0 Human 6.0 pIC50 = 6 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 402 7 1 6 3.0 COc1ccc2nc3ccc(C(=O)NCCCCc4cccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
CHEMBL293362 107609 0 None - 0 Human 6.0 pIC50 = 6 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 402 7 1 6 3.0 COc1ccc2nc3ccc(C(=O)NCCCCc4cccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
13557495 204946 0 None - 0 Human 6.0 pIC50 = 6 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 406 6 1 5 3.6 O=C(NCCCCc1cccnc1)c1ccc2nc3cc(Cl)ccc3c(=O)n2c1 10.1021/jm00397a034
CHEMBL57489 204946 0 None - 0 Human 6.0 pIC50 = 6 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 406 6 1 5 3.6 O=C(NCCCCc1cccnc1)c1ccc2nc3cc(Cl)ccc3c(=O)n2c1 10.1021/jm00397a034
23214200 55677 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 558 11 2 8 6.7 CCCOc1c(NC(=O)N(O)C2CCCCC2)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
CHEMBL155975 55677 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 558 11 2 8 6.7 CCCOc1c(NC(=O)N(O)C2CCCCC2)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
15084138 116528 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 396 2 2 7 3.7 Cc1nnc2n1-c1sc(-c3cc(O)[nH]n3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL32303 116528 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 396 2 2 7 3.7 Cc1nnc2n1-c1sc(-c3cc(O)[nH]n3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
15084139 120304 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 494 3 1 9 2.9 Cc1nnc2n1-c1sc(-c3[nH]nnc3C(=O)N3CCOCC3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL33217 120304 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 494 3 1 9 2.9 Cc1nnc2n1-c1sc(-c3[nH]nnc3C(=O)N3CCOCC3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
44283932 18770 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 358 8 0 4 3.4 COc1ccc([C@H]2CC[C@@H](OCCCc3ccc[n+](C)c3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
CHEMBL1183269 18770 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 358 8 0 4 3.4 COc1ccc([C@H]2CC[C@@H](OCCCc3ccc[n+](C)c3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
CHEMBL287821 18770 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 358 8 0 4 3.4 COc1ccc([C@H]2CC[C@@H](OCCCc3ccc[n+](C)c3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
44283769 144638 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 317 6 0 3 4.6 Clc1ccc([C@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1 10.1016/S0960-894X(00)80005-0
CHEMBL37603 144638 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 317 6 0 3 4.6 Clc1ccc([C@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1 10.1016/S0960-894X(00)80005-0
10618661 213400 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 362 4 0 5 3.4 COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CC[C@]1(CO1)[C@@H]2CCC1=CCOC1=O 10.1021/jm970569j
CHEMBL89088 213400 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 362 4 0 5 3.4 COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CC[C@]1(CO1)[C@@H]2CCC1=CCOC1=O 10.1021/jm970569j
10809563 46075 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 376 3 0 4 4.9 CCC(=O)OC[C@H]1[C@H]2CC[C@@H](C)[C@]1(C)CC/C(C)=C/CC[C@@]1(C)O[C@@H]1C2=O 10.1021/jm950640q
CHEMBL147079 46075 0 None - 0 Guinea pig 6.0 pIC50 = 6 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 376 3 0 4 4.9 CCC(=O)OC[C@H]1[C@H]2CC[C@@H](C)[C@]1(C)CC/C(C)=C/CC[C@@]1(C)O[C@@H]1C2=O 10.1021/jm950640q
44340797 16354 2 None - 1 Guinea pig 6.0 pIC50 = 6 Binding
Inhibitory concentration required to inhibit PAF binding to rabbit platelet membraneInhibitory concentration required to inhibit PAF binding to rabbit platelet membrane
ChEMBL 372 6 0 5 4.8 COc1ccc([C@H]2O[C@@H](c3ccc(OC)c(OC)c3)[C@H](C)[C@H]2C)cc1OC 10.1016/S0960-894X(01)80818-0
CHEMBL112481 16354 2 None - 1 Guinea pig 6.0 pIC50 = 6 Binding
Inhibitory concentration required to inhibit PAF binding to rabbit platelet membraneInhibitory concentration required to inhibit PAF binding to rabbit platelet membrane
ChEMBL 372 6 0 5 4.8 COc1ccc([C@H]2O[C@@H](c3ccc(OC)c(OC)c3)[C@H](C)[C@H]2C)cc1OC 10.1016/S0960-894X(01)80818-0
14894667 81769 0 None - 0 Human 6.0 pIC50 = 6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 461 2 0 6 3.4 O=C1c2ccccc2C(=O)N1CC#Cc1ccc2c(c1)C(c1ccccc1F)=NCc1nncn1-2 10.1021/jm00107a048
CHEMBL20325 81769 0 None - 0 Human 6.0 pIC50 = 6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 461 2 0 6 3.4 O=C1c2ccccc2C(=O)N1CC#Cc1ccc2c(c1)C(c1ccccc1F)=NCc1nncn1-2 10.1021/jm00107a048
14851835 82903 0 None - 0 Human 6.0 pIC50 = 6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 418 1 0 4 3.7 Cc1nnc2n1-c1ccc(I)cc1C(c1ccccc1F)=NC2 10.1021/jm00107a048
CHEMBL20577 82903 0 None - 0 Human 6.0 pIC50 = 6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 418 1 0 4 3.7 Cc1nnc2n1-c1ccc(I)cc1C(c1ccccc1F)=NC2 10.1021/jm00107a048
14851894 84554 0 None - 0 Human 6.0 pIC50 = 6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 434 1 0 4 4.2 Cc1nnc2n1-c1ccc(I)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20914 84554 0 None - 0 Human 6.0 pIC50 = 6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 434 1 0 4 4.2 Cc1nnc2n1-c1ccc(I)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
44273438 105803 0 None - 0 Human 6.0 pIC50 = 6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 489 2 0 5 5.0 Cc1nnc2n1-c1ccc(C#CCN3C(=O)CCc4ccccc43)cc1C(c1ccccc1F)=N[C@@H]2C 10.1021/jm00107a048
CHEMBL280207 105803 0 None - 0 Human 6.0 pIC50 = 6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 489 2 0 5 5.0 Cc1nnc2n1-c1ccc(C#CCN3C(=O)CCc4ccccc43)cc1C(c1ccccc1F)=N[C@@H]2C 10.1021/jm00107a048
14851927 106292 0 None - 0 Human 6.0 pIC50 = 6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 545 2 0 5 5.6 O=C1CCc2ccccc2N1CC#Cc1ccc2c(c1)C(c1ccc(Cl)cc1)=NCc1nnc(C(F)(F)F)n1-2 10.1021/jm00107a048
CHEMBL283365 106292 0 None - 0 Human 6.0 pIC50 = 6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 545 2 0 5 5.6 O=C1CCc2ccccc2N1CC#Cc1ccc2c(c1)C(c1ccc(Cl)cc1)=NCc1nnc(C(F)(F)F)n1-2 10.1021/jm00107a048
44273297 170005 0 None - 0 Human 6.0 pIC50 = 6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 420 1 1 4 3.5 Cc1nnc2n1-c1ccc(I)cc1C(c1ccccc1F)NC2 10.1021/jm00107a048
CHEMBL418370 170005 0 None - 0 Human 6.0 pIC50 = 6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 420 1 1 4 3.5 Cc1nnc2n1-c1ccc(I)cc1C(c1ccccc1F)NC2 10.1021/jm00107a048
10243193 111315 1 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 236 1 0 3 2.9 C1=C(c2ccco2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
CHEMBL310425 111315 1 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 236 1 0 3 2.9 C1=C(c2ccco2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
10444655 212254 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 247 1 0 3 2.7 C1=C(c2cccnc2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
CHEMBL80505 212254 0 None - 0 Human 4.0 pIC50 = 4 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 247 1 0 3 2.7 C1=C(c2cccnc2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
44370579 126744 3 None - 0 Human 8.0 pIC50 = 8.0 Binding
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
ChEMBL 425 5 1 5 5.2 O=C(c1ccccc1)c1cccc(NC(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c1 10.1016/S0960-894X(01)81205-1
CHEMBL349811 126744 3 None - 0 Human 8.0 pIC50 = 8.0 Binding
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
ChEMBL 425 5 1 5 5.2 O=C(c1ccccc1)c1cccc(NC(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c1 10.1016/S0960-894X(01)81205-1
44281548 106782 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 456 3 0 5 6.3 Cc1nnc2n1-c1sc(/C=C\c3ccc4c(c3)CCC4)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL286762 106782 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 456 3 0 5 6.3 Cc1nnc2n1-c1sc(/C=C\c3ccc4c(c3)CCC4)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
44273266 105925 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 477 2 1 6 3.6 Cc1nnc2n1-c1ccc(C#CCN3C(=O)c4ccccc4C3=O)cc1C(c1ccccc1F)NC2 10.1021/jm00107a048
CHEMBL281139 105925 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 477 2 1 6 3.6 Cc1nnc2n1-c1ccc(C#CCN3C(=O)c4ccccc4C3=O)cc1C(c1ccccc1F)NC2 10.1021/jm00107a048
44299954 107336 0 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
Inhibition of PAF receptor binding to rabbit platelet plasma membranesInhibition of PAF receptor binding to rabbit platelet plasma membranes
ChEMBL 372 6 0 5 4.8 COc1ccc(C2O[C@@H](c3ccc(OC)c(OC)c3)[C@@H](C)[C@@H]2C)cc1OC 10.1021/jm00160a020
CHEMBL291515 107336 0 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
Inhibition of PAF receptor binding to rabbit platelet plasma membranesInhibition of PAF receptor binding to rabbit platelet plasma membranes
ChEMBL 372 6 0 5 4.8 COc1ccc(C2O[C@@H](c3ccc(OC)c(OC)c3)[C@@H](C)[C@@H]2C)cc1OC 10.1021/jm00160a020
7099836 203948 1 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
Inhibition of PAF receptor binding to rabbit platelet plasma membranesInhibition of PAF receptor binding to rabbit platelet plasma membranes
ChEMBL 372 6 0 5 4.8 COc1ccc([C@@H]2O[C@@H](c3ccc(OC)c(OC)c3)[C@H](C)[C@@H]2C)cc1OC 10.1021/jm00160a020
CHEMBL56800 203948 1 None - 0 Guinea pig 6.0 pIC50 = 6.0 Binding
Inhibition of PAF receptor binding to rabbit platelet plasma membranesInhibition of PAF receptor binding to rabbit platelet plasma membranes
ChEMBL 372 6 0 5 4.8 COc1ccc([C@@H]2O[C@@H](c3ccc(OC)c(OC)c3)[C@H](C)[C@@H]2C)cc1OC 10.1021/jm00160a020
10021505 170281 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 361 3 0 4 3.8 C1=C(c2ccc(CN3CCSCC3)cc2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
CHEMBL420208 170281 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 361 3 0 4 3.8 C1=C(c2ccc(CN3CCSCC3)cc2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
9998465 212199 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 357 3 0 3 4.6 CC1CCCCN1Cc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
CHEMBL80179 212199 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 357 3 0 3 4.6 CC1CCCCN1Cc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
10060480 212190 1 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 246 1 0 2 3.3 C1=C(c2ccccc2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
CHEMBL80130 212190 1 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 246 1 0 2 3.3 C1=C(c2ccccc2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
44399100 140391 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor in human plateletInhibition of [3H]PAF binding to platelet activating factor receptor in human platelet
ChEMBL 334 0 2 4 3.1 C/C1=C\CC[C@]2(C)O[C@H]2[C@@]2(O)OCC3=C2[C@H](O)C[C@@H](C)[C@]3(C)CC1 10.1016/j.bmcl.2005.04.048
CHEMBL371351 140391 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor in human plateletInhibition of [3H]PAF binding to platelet activating factor receptor in human platelet
ChEMBL 334 0 2 4 3.1 C/C1=C\CC[C@]2(C)O[C@H]2[C@@]2(O)OCC3=C2[C@H](O)C[C@@H](C)[C@]3(C)CC1 10.1016/j.bmcl.2005.04.048
14964730 115520 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 441 7 0 6 4.7 COc1cc(CCc2ccc(C3=Nc4ccccc4C4=NCCN34)cc2)cc(OC)c1OC 10.1021/jm00073a008
CHEMBL320871 115520 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 441 7 0 6 4.7 COc1cc(CCc2ccc(C3=Nc4ccccc4C4=NCCN34)cc2)cc(OC)c1OC 10.1021/jm00073a008
73356389 96304 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor in human plateletInhibition of [3H]PAF binding to platelet activating factor receptor in human platelet
ChEMBL 318 0 1 3 4.1 C/C1=C\[C@@]2(O)OC[C@]34O[C@@]32CC[C@@H](C)[C@@]4(C)CC/C(C)=C/CC1 10.1016/j.bmcl.2005.04.048
CHEMBL2373409 96304 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor in human plateletInhibition of [3H]PAF binding to platelet activating factor receptor in human platelet
ChEMBL 318 0 1 3 4.1 C/C1=C\[C@@]2(O)OC[C@]34O[C@@]32CC[C@@H](C)[C@@]4(C)CC/C(C)=C/CC1 10.1016/j.bmcl.2005.04.048
14347344 201333 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 472 11 1 6 5.0 O=C(/C=C/C=C(c1cccc([N+](=O)[O-])c1)c1cccc([N+](=O)[O-])c1)NCCCCc1cccnc1 10.1021/jm00128a026
CHEMBL52970 201333 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 472 11 1 6 5.0 O=C(/C=C/C=C(c1cccc([N+](=O)[O-])c1)c1cccc([N+](=O)[O-])c1)NCCCCc1cccnc1 10.1021/jm00128a026
132115 18491 1 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 575 23 0 5 8.1 CCCCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1016/S0960-894X(00)80005-0
CHEMBL1181271 18491 1 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 575 23 0 5 8.1 CCCCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1016/S0960-894X(00)80005-0
CHEMBL161096 18491 1 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 575 23 0 5 8.1 CCCCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1016/S0960-894X(00)80005-0
CHEMBL290840 18491 1 None - 0 Human 7.9 pIC50 = 7.9 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 575 23 0 5 8.1 CCCCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1 10.1016/S0960-894X(00)80005-0
14851858 105830 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 547 2 0 7 5.4 Cc1nnc2n1-c1sc(C#CCN3C(=O)c4cccc5cccc(c45)C3=O)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL280401 105830 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 547 2 0 7 5.4 Cc1nnc2n1-c1sc(C#CCN3C(=O)c4cccc5cccc(c45)C3=O)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14851880 106321 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 537 2 0 6 5.6 Cc1nnc2n1-c1sc(C#CCN3C(=O)C4(C)CCCc5cccc3c54)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL283525 106321 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 537 2 0 6 5.6 Cc1nnc2n1-c1sc(C#CCN3C(=O)C4(C)CCCc5cccc3c54)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
44273257 169611 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 525 2 0 6 5.7 Cc1nnc2n1-c1sc(C#CCN3C(=O)CC(C)(C)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL417275 169611 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 525 2 0 6 5.7 Cc1nnc2n1-c1sc(C#CCN3C(=O)CC(C)(C)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
44281549 117099 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 498 4 0 5 7.9 Cc1nnc2n1-c1sc(/C=C\c3ccc(C4CCCCC4)cc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL32389 117099 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 498 4 0 5 7.9 Cc1nnc2n1-c1sc(/C=C\c3ccc(C4CCCCC4)cc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
10018799 126607 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 318 1 0 3 4.1 C/C1=C\CC[C@@]2(C)O[C@@H]2C(=O)[C@@H]2CC[C@@H](C)[C@](C)(CC1)[C@H]2C=O 10.1021/jm950640q
CHEMBL348494 126607 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 318 1 0 3 4.1 C/C1=C\CC[C@@]2(C)O[C@@H]2C(=O)[C@@H]2CC[C@@H](C)[C@](C)(CC1)[C@H]2C=O 10.1021/jm950640q
9820228 126347 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 359 11 0 5 5.0 CCCCCCCC1CCC(OCCCn2c(C)nc3cnccc32)O1 10.1016/S0960-894X(00)80006-2
CHEMBL34612 126347 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 359 11 0 5 5.0 CCCCCCCC1CCC(OCCCn2c(C)nc3cnccc32)O1 10.1016/S0960-894X(00)80006-2
14547295 201742 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 470 12 1 4 6.0 CC[C@H](CCCc1cccnc1)NC(=O)/C=C/C=C(c1ccc(OC)cc1)c1ccc(OC)cc1 10.1021/jm00128a026
CHEMBL54482 201742 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 470 12 1 4 6.0 CC[C@H](CCCc1cccnc1)NC(=O)/C=C/C=C(c1ccc(OC)cc1)c1ccc(OC)cc1 10.1021/jm00128a026
122159 108131 19 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Inhibitor concentration required to block 50% of the specific [3H]PAF binding to rabbit platelet membranes.Inhibitor concentration required to block 50% of the specific [3H]PAF binding to rabbit platelet membranes.
ChEMBL 356 6 0 5 3.8 C=CCC1=C[C@@]2(OC)C(=CC1=O)O[C@H](c1ccc(OC)c(OC)c1)[C@H]2C 10.1021/jm00384a023
CHEMBL296958 108131 19 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Inhibitor concentration required to block 50% of the specific [3H]PAF binding to rabbit platelet membranes.Inhibitor concentration required to block 50% of the specific [3H]PAF binding to rabbit platelet membranes.
ChEMBL 356 6 0 5 3.8 C=CCC1=C[C@@]2(OC)C(=CC1=O)O[C@H](c1ccc(OC)c(OC)c1)[C@H]2C 10.1021/jm00384a023
14851878 83664 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 517 2 0 6 6.8 Cc1nnc2n1-c1sc(C#CCn3c4ccccc4c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20701 83664 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 517 2 0 6 6.8 Cc1nnc2n1-c1sc(C#CCn3c4ccccc4c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14851914 106243 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 454 1 0 5 4.8 Cc1nnc2n1-c1sc(I)cc1C(c1ccccc1Cl)=NC2C 10.1021/jm00107a048
CHEMBL283113 106243 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 454 1 0 5 4.8 Cc1nnc2n1-c1sc(I)cc1C(c1ccccc1Cl)=NC2C 10.1021/jm00107a048
13739736 108725 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 442 7 1 5 4.9 CC(C)c1ccc2nc3ccc(C(=O)NC(C)(C)CCCc4cccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
CHEMBL301215 108725 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 442 7 1 5 4.9 CC(C)c1ccc2nc3ccc(C(=O)NC(C)(C)CCCc4cccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
13557477 204932 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 388 6 2 6 2.7 O=C(NCCCCc1cccnc1)c1ccc2nc3ccc(O)cc3c(=O)n2c1 10.1021/jm00397a034
CHEMBL57480 204932 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 388 6 2 6 2.7 O=C(NCCCCc1cccnc1)c1ccc2nc3ccc(O)cc3c(=O)n2c1 10.1021/jm00397a034
10498071 213489 0 None - 0 Guinea pig 4.9 pIC50 = 4.9 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 350 6 2 4 3.6 C=C1CCC2[C@@](C)(C(=O)OC)CCC[C@]2(C)[C@H]1CC/C(=C/CO)CO 10.1021/jm970569j
CHEMBL89784 213489 0 None - 0 Guinea pig 4.9 pIC50 = 4.9 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 350 6 2 4 3.6 C=C1CCC2[C@@](C)(C(=O)OC)CCC[C@]2(C)[C@H]1CC/C(=C/CO)CO 10.1021/jm970569j
14570094 195223 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 466 10 1 4 6.2 COc1ccc(-c2ccc(C(=O)NCCCCc3cccnc3)cc2-c2ccc(OC)cc2)cc1 10.1021/jm00128a025
CHEMBL50250 195223 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 466 10 1 4 6.2 COc1ccc(-c2ccc(C(=O)NCCCCc3cccnc3)cc2-c2ccc(OC)cc2)cc1 10.1021/jm00128a025
11450461 96305 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor in human plateletInhibition of [3H]PAF binding to platelet activating factor receptor in human platelet
ChEMBL 334 0 2 4 3.1 C/C1=C\CC[C@]2(C)O[C@@H]3C[C@@H](C)[C@@](C)(CC1)C1=C3[C@](O)(OC1)[C@H]2O 10.1016/j.bmcl.2005.04.048
CHEMBL2373416 96305 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor in human plateletInhibition of [3H]PAF binding to platelet activating factor receptor in human platelet
ChEMBL 334 0 2 4 3.1 C/C1=C\CC[C@]2(C)O[C@@H]3C[C@@H](C)[C@@](C)(CC1)C1=C3[C@](O)(OC1)[C@H]2O 10.1016/j.bmcl.2005.04.048
6324617 196342 27 None - 1 Human 6.9 pIC50 = 6.9 Binding
Compound was evaluated for anti-platelet activating factor potencyCompound was evaluated for anti-platelet activating factor potency
ChEMBL 424 0 3 10 -1.4 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6O)O[C@@]4(C(=O)O5)[C@@]12O 10.1016/s0960-894x(98)00205-4
CHEMBL514432 196342 27 None - 1 Human 6.9 pIC50 = 6.9 Binding
Compound was evaluated for anti-platelet activating factor potencyCompound was evaluated for anti-platelet activating factor potency
ChEMBL 424 0 3 10 -1.4 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6O)O[C@@]4(C(=O)O5)[C@@]12O 10.1016/s0960-894x(98)00205-4
129796 107232 39 None - 1 Human 7.9 pIC50 = 7.9 Binding
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1016/S0960-894X(01)81205-1
CHEMBL29067 107232 39 None - 1 Human 7.9 pIC50 = 7.9 Binding
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1016/S0960-894X(01)81205-1
5312127 70093 1 None - 1 Human 7.9 pIC50 = 7.9 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 480 10 0 8 4.5 CCCOc1c(OC)cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(C)(=O)=O 10.1016/S0960-894X(00)80005-0
CHEMBL1793831 70093 1 None - 1 Human 7.9 pIC50 = 7.9 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 480 10 0 8 4.5 CCCOc1c(OC)cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(C)(=O)=O 10.1016/S0960-894X(00)80005-0
5312127 70093 1 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 480 10 0 8 4.5 CCCOc1c(OC)cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(C)(=O)=O 10.1016/S0960-894X(00)80006-2
CHEMBL1793831 70093 1 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 480 10 0 8 4.5 CCCOc1c(OC)cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(C)(=O)=O 10.1016/S0960-894X(00)80006-2
60775 105481 19 None - 0 Human 7.9 pIC50 = 7.9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 545 2 0 7 6.2 Cc1nnc2n1-c1sc(C#CCn3c(=O)c4ccccc4c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL277650 105481 19 None - 0 Human 7.9 pIC50 = 7.9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 545 2 0 7 6.2 Cc1nnc2n1-c1sc(C#CCn3c(=O)c4ccccc4c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
10547822 47569 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 380 2 1 5 4.5 COC(=O)OC[C@H]1[C@H]2CC[C@@H](C)[C@]1(C)CC/C(C)=C/CC[C@@]1(C)O[C@@H]1[C@@H]2O 10.1021/jm950640q
CHEMBL148549 47569 0 None - 0 Guinea pig 6.9 pIC50 = 6.9 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 380 2 1 5 4.5 COC(=O)OC[C@H]1[C@H]2CC[C@@H](C)[C@]1(C)CC/C(C)=C/CC[C@@]1(C)O[C@@H]1[C@@H]2O 10.1021/jm950640q
14851856 81804 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 439 3 0 6 4.4 Cc1nnc2n1-c1ccc(C#CCOc3cccnc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20344 81804 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 439 3 0 6 4.4 Cc1nnc2n1-c1ccc(C#CCOc3cccnc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
13557466 204402 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 414 7 1 5 4.1 CC(C)c1ccc2nc3ccc(C(=O)NCCCCc4ccncc4)cn3c(=O)c2c1 10.1021/jm00397a034
CHEMBL57072 204402 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 414 7 1 5 4.1 CC(C)c1ccc2nc3ccc(C(=O)NCCCCc4ccncc4)cn3c(=O)c2c1 10.1021/jm00397a034
10448705 126311 0 None - 0 Guinea pig 5.9 pIC50 = 5.9 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 320 1 1 3 3.9 C/C1=C\CC[C@@]2(C)O[C@@H]2C(=O)[C@@H]2CC[C@@H](C)[C@](C)(CC1)[C@H]2CO 10.1021/jm950640q
CHEMBL345748 126311 0 None - 0 Guinea pig 5.9 pIC50 = 5.9 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 320 1 1 3 3.9 C/C1=C\CC[C@@]2(C)O[C@@H]2C(=O)[C@@H]2CC[C@@H](C)[C@](C)(CC1)[C@H]2CO 10.1021/jm950640q
10048859 212288 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 439 5 0 3 6.7 C1=C(c2ccc(CN(C3CCCCC3)C3CCCCC3)cc2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
CHEMBL80774 212288 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 439 5 0 3 6.7 C1=C(c2ccc(CN(C3CCCCC3)C3CCCCC3)cc2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
23214264 126397 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 532 13 2 8 6.1 CCCCN(O)C(=O)Nc1cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCC 10.1016/0960-894X(95)00088-B
CHEMBL346538 126397 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 532 13 2 8 6.1 CCCCN(O)C(=O)Nc1cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCC 10.1016/0960-894X(95)00088-B
14347409 108089 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 406 12 1 3 5.7 CCCC/C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1021/jm00128a026
CHEMBL296600 108089 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 406 12 1 3 5.7 CCCC/C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1021/jm00128a026
14570113 108641 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 406 9 1 4 5.5 COc1ccc(-c2ccc(C(S)=NCCCCc3cccnc3)cc2)cc1OC 10.1021/jm00128a025
CHEMBL300644 108641 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 406 9 1 4 5.5 COc1ccc(-c2ccc(C(S)=NCCCCc3cccnc3)cc2)cc1OC 10.1021/jm00128a025
10244542 112280 1 None - 0 Human 4.9 pIC50 = 4.9 Binding
Compound were tested for the inhibition of [3H]PAF binding to human platelets.Compound were tested for the inhibition of [3H]PAF binding to human platelets.
ChEMBL 264 1 0 2 3.4 Fc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
CHEMBL312130 112280 1 None - 0 Human 4.9 pIC50 = 4.9 Binding
Compound were tested for the inhibition of [3H]PAF binding to human platelets.Compound were tested for the inhibition of [3H]PAF binding to human platelets.
ChEMBL 264 1 0 2 3.4 Fc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
44399202 133551 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor in human plateletInhibition of [3H]PAF binding to platelet activating factor receptor in human platelet
ChEMBL 334 0 2 4 3.1 C/C1=C\CC[C@@]2(C)O[C@@H]2[C@@]2(O)OCC3=C2[C@@H](O)C[C@@H](C)[C@]3(C)CC1 10.1016/j.bmcl.2005.04.048
CHEMBL365357 133551 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor in human plateletInhibition of [3H]PAF binding to platelet activating factor receptor in human platelet
ChEMBL 334 0 2 4 3.1 C/C1=C\CC[C@@]2(C)O[C@@H]2[C@@]2(O)OCC3=C2[C@@H](O)C[C@@H](C)[C@]3(C)CC1 10.1016/j.bmcl.2005.04.048
44328930 214841 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 430 11 1 3 6.1 CCCCc1c(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)ccc2ccc(OC)cc12 10.1021/jm00172a029
CHEMBL97630 214841 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 430 11 1 3 6.1 CCCCc1c(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)ccc2ccc(OC)cc12 10.1021/jm00172a029
44284614 127995 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 397 8 0 7 4.0 COc1ccc(C2CCC(OCCCn3c(C)nc4cnccc43)O2)cc1OC 10.1016/S0960-894X(00)80006-2
CHEMBL35776 127995 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 397 8 0 7 4.0 COc1ccc(C2CCC(OCCCn3c(C)nc4cnccc43)O2)cc1OC 10.1016/S0960-894X(00)80006-2
14570089 201518 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 404 9 1 4 4.9 COc1ccc(-c2ccc(C(=O)N[C@H](C)CCCc3cccnc3)cc2)cc1OC 10.1021/jm00128a025
CHEMBL53585 201518 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 404 9 1 4 4.9 COc1ccc(-c2ccc(C(=O)N[C@H](C)CCCc3cccnc3)cc2)cc1OC 10.1021/jm00128a025
44273441 83446 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 535 2 0 6 6.9 Cc1nnc2n1-c1sc(C#CCn3c4c(c5ccccc53)CCCCC4)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20644 83446 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 535 2 0 6 6.9 Cc1nnc2n1-c1sc(C#CCn3c4c(c5ccccc53)CCCCC4)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
44273385 105485 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 556 2 0 7 5.6 Cc1nnc2n1-c1sc(C#CCN3C(=O)Cn4ccc5c(Cl)ccc3c54)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL277678 105485 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 556 2 0 7 5.6 Cc1nnc2n1-c1sc(C#CCN3C(=O)Cn4ccc5c(Cl)ccc3c54)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
44273282 170037 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 561 2 0 8 5.5 Cc1nnc2n1-c1sc(C#CCn3c(=O)c4ccccc4c4ccccc43)cc1C(C1=CC(=O)CC=C1Cl)=NC2 10.1021/jm00107a048
CHEMBL418556 170037 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 561 2 0 8 5.5 Cc1nnc2n1-c1sc(C#CCn3c(=O)c4ccccc4c4ccccc43)cc1C(C1=CC(=O)CC=C1Cl)=NC2 10.1021/jm00107a048
14851839 174538 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 541 2 0 6 5.4 Cc1nnc2n1-c1ccc(C#CCN3C(=O)c4cccc5cccc(c45)C3=O)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL430333 174538 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 541 2 0 6 5.4 Cc1nnc2n1-c1ccc(C#CCN3C(=O)c4cccc5cccc(c45)C3=O)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14851930 115685 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Compound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog plateletsCompound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets
ChEMBL 464 1 0 5 6.2 Cc1nnc2n1-c1sc(C#Cc3cccc4ccccc34)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL32110 115685 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Compound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog plateletsCompound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets
ChEMBL 464 1 0 5 6.2 Cc1nnc2n1-c1sc(C#Cc3cccc4ccccc34)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
44283865 146297 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 343 8 0 5 3.9 COc1ccc([C@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
CHEMBL37951 146297 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 343 8 0 5 3.9 COc1ccc([C@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
9862913 106695 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 343 8 0 5 3.9 COc1ccc([C@@H]2CC[C@H](OCCCc3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80006-2
CHEMBL286197 106695 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 343 8 0 5 3.9 COc1ccc([C@@H]2CC[C@H](OCCCc3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80006-2
122159 108131 19 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Inhibitory concentration required to inhibit PAF binding to rabbit platelet membraneInhibitory concentration required to inhibit PAF binding to rabbit platelet membrane
ChEMBL 356 6 0 5 3.8 C=CCC1=C[C@@]2(OC)C(=CC1=O)O[C@H](c1ccc(OC)c(OC)c1)[C@H]2C 10.1016/S0960-894X(01)80818-0
CHEMBL296958 108131 19 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Inhibitory concentration required to inhibit PAF binding to rabbit platelet membraneInhibitory concentration required to inhibit PAF binding to rabbit platelet membrane
ChEMBL 356 6 0 5 3.8 C=CCC1=C[C@@]2(OC)C(=CC1=O)O[C@H](c1ccc(OC)c(OC)c1)[C@H]2C 10.1016/S0960-894X(01)80818-0
44273289 78696 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 583 5 0 10 3.7 Cc1nnc2n1-c1sc(C#CCn3c(=O)n(CCN(C)C)c(=O)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL19721 78696 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 583 5 0 10 3.7 Cc1nnc2n1-c1sc(C#CCn3c(=O)n(CCN(C)C)c(=O)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
44283798 124126 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 373 9 0 6 3.9 COc1cc([C@@H]2CC[C@@H](OCCCc3cccnc3)O2)cc(OC)c1OC 10.1016/S0960-894X(00)80005-0
CHEMBL33972 124126 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 373 9 0 6 3.9 COc1cc([C@@H]2CC[C@@H](OCCCc3cccnc3)O2)cc(OC)c1OC 10.1016/S0960-894X(00)80005-0
44284169 132966 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 329 7 0 5 3.5 COc1ccc(C2CCC(OCCc3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
CHEMBL36494 132966 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 329 7 0 5 3.5 COc1ccc(C2CCC(OCCc3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
44299770 107312 0 None - 0 Guinea pig 4.8 pIC50 = 4.8 Binding
Inhibition of PAF receptor binding to rabbit platelet plasma membranesInhibition of PAF receptor binding to rabbit platelet plasma membranes
ChEMBL 404 8 0 7 4.3 COc1cc(C2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OC 10.1021/jm00160a020
CHEMBL291332 107312 0 None - 0 Guinea pig 4.8 pIC50 = 4.8 Binding
Inhibition of PAF receptor binding to rabbit platelet plasma membranesInhibition of PAF receptor binding to rabbit platelet plasma membranes
ChEMBL 404 8 0 7 4.3 COc1cc(C2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OC 10.1021/jm00160a020
10060780 212196 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 252 1 0 3 3.3 C1=C(c2cccs2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
CHEMBL80165 212196 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 252 1 0 3 3.3 C1=C(c2cccs2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
44284057 17960 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 334 13 0 2 5.0 CCCCCCC1CCC(OCCCCCC[n+]2ccccc2)O1 10.1016/S0960-894X(00)80005-0
CHEMBL1178669 17960 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 334 13 0 2 5.0 CCCCCCC1CCC(OCCCCCC[n+]2ccccc2)O1 10.1016/S0960-894X(00)80005-0
CHEMBL36733 17960 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 334 13 0 2 5.0 CCCCCCC1CCC(OCCCCCC[n+]2ccccc2)O1 10.1016/S0960-894X(00)80005-0
10642544 113675 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 364 5 1 5 3.3 COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CC[C@H](CO)[C@@H]2CCC1=CCOC1=O 10.1021/jm970569j
CHEMBL314577 113675 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 364 5 1 5 3.3 COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CC[C@H](CO)[C@@H]2CCC1=CCOC1=O 10.1021/jm970569j
44372435 60421 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 532 12 2 8 6.1 CCCOc1c(NC(=O)N(O)C(C)CC)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
CHEMBL160290 60421 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 532 12 2 8 6.1 CCCOc1c(NC(=O)N(O)C(C)CC)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
10652101 86288 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 674 16 2 9 7.8 CCCCN(O)C(=O)NCc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCSc1ccc(Cl)cc1 10.1021/jm980046r
CHEMBL2113731 86288 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 674 16 2 9 7.8 CCCCN(O)C(=O)NCc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCSc1ccc(Cl)cc1 10.1021/jm980046r
44372409 60919 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 490 10 2 8 5.0 CCCOc1c(NC(=O)N(C)O)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
CHEMBL160692 60919 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 490 10 2 8 5.0 CCCOc1c(NC(=O)N(C)O)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
44372440 126624 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 560 14 1 8 6.5 CCCOc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(N(CC)C(=O)N(O)CC)c1OCCC 10.1016/0960-894X(95)00088-B
CHEMBL348609 126624 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 560 14 1 8 6.5 CCCOc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(N(CC)C(=O)N(O)CC)c1OCCC 10.1016/0960-894X(95)00088-B
14347348 201810 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 432 9 1 2 5.9 C[C@H](CCCc1cccnc1)NC(=O)/C=C/C=C(c1cccc(F)c1)c1cccc(F)c1 10.1021/jm00128a026
CHEMBL54935 201810 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 432 9 1 2 5.9 C[C@H](CCCc1cccnc1)NC(=O)/C=C/C=C(c1cccc(F)c1)c1cccc(F)c1 10.1021/jm00128a026
10688041 113650 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 332 5 0 3 4.7 C=C1CCC2[C@@](C)(COC)CCC[C@]2(C)[C@H]1CCC1=CCOC1=O 10.1021/jm970569j
CHEMBL314507 113650 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 332 5 0 3 4.7 C=C1CCC2[C@@](C)(COC)CCC[C@]2(C)[C@H]1CCC1=CCOC1=O 10.1021/jm970569j
44322197 213051 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 360 5 0 5 3.5 COC(=O)[C@@]1(C)CCC[C@]2(C)C(CCC3=CCOC3=O)=C(C=O)CCC12 10.1021/jm970569j
CHEMBL86916 213051 0 None - 0 Guinea pig 5.8 pIC50 = 5.8 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 360 5 0 5 3.5 COC(=O)[C@@]1(C)CCC[C@]2(C)C(CCC3=CCOC3=O)=C(C=O)CCC12 10.1021/jm970569j
44366103 50415 0 None - 0 Guinea pig 4.8 pIC50 = 4.8 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 334 1 0 4 3.3 C[C@@H]1CC[C@H]2C(=O)[C@H]3O[C@]3(C)CC[C@@H]3O[C@@]3(C)CC[C@]1(C)[C@H]2C=O 10.1021/jm950640q
CHEMBL150968 50415 0 None - 0 Guinea pig 4.8 pIC50 = 4.8 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 334 1 0 4 3.3 C[C@@H]1CC[C@H]2C(=O)[C@H]3O[C@]3(C)CC[C@@H]3O[C@@]3(C)CC[C@]1(C)[C@H]2C=O 10.1021/jm950640q
10448393 111554 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 314 1 0 2 4.6 Clc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1Cl 10.1021/jm00002a004
CHEMBL310866 111554 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 314 1 0 2 4.6 Clc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1Cl 10.1021/jm00002a004
14570110 201575 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 446 12 1 4 5.9 CCCCc1cc(C(=O)NCCCCc2cccnc2)ccc1-c1ccc(OC)c(OC)c1 10.1021/jm00128a025
CHEMBL53867 201575 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 446 12 1 4 5.9 CCCCc1cc(C(=O)NCCCCc2cccnc2)ccc1-c1ccc(OC)c(OC)c1 10.1021/jm00128a025
44299770 107312 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 404 8 0 7 4.3 COc1cc(C2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OC 10.1021/jm00397a034
CHEMBL291332 107312 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 404 8 0 7 4.3 COc1cc(C2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OC 10.1021/jm00397a034
14850516 106752 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 453 3 0 7 3.5 Cc1nnc2n1-c1sc(/C=C\C(=O)N3CCOCC3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL286557 106752 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 453 3 0 7 3.5 Cc1nnc2n1-c1sc(/C=C\C(=O)N3CCOCC3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
15084135 116566 26 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 368 1 1 6 3.0 Cc1nnc2n1-c1sc(C#CCO)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL32327 116566 26 None - 0 Human 6.8 pIC50 = 6.8 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 368 1 1 6 3.0 Cc1nnc2n1-c1sc(C#CCO)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
10668293 50536 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 393 2 1 4 4.4 C/C1=C\CC[C@@]2(C)O[C@@H]2[C@H](O)[C@@H]2CC[C@@H](C)[C@](C)(CC1)[C@H]2COC(=O)N(C)C 10.1021/jm950640q
CHEMBL151075 50536 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 393 2 1 4 4.4 C/C1=C\CC[C@@]2(C)O[C@@H]2[C@H](O)[C@@H]2CC[C@@H](C)[C@](C)(CC1)[C@H]2COC(=O)N(C)C 10.1021/jm950640q
10500673 50753 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 391 2 0 4 4.6 C/C1=C\CC[C@@]2(C)O[C@@H]2C(=O)[C@@H]2CC[C@@H](C)[C@](C)(CC1)[C@H]2COC(=O)N(C)C 10.1021/jm950640q
CHEMBL151310 50753 0 None - 0 Guinea pig 6.8 pIC50 = 6.8 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 391 2 0 4 4.6 C/C1=C\CC[C@@]2(C)O[C@@H]2C(=O)[C@@H]2CC[C@@H](C)[C@](C)(CC1)[C@H]2COC(=O)N(C)C 10.1021/jm950640q
14570100 201533 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 482 9 1 4 5.7 COc1ccc(-c2ccc(C(=O)N[C@H](C)CCCc3cccnc3)cc2Br)cc1OC 10.1021/jm00128a025
CHEMBL53750 201533 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 482 9 1 4 5.7 COc1ccc(-c2ccc(C(=O)N[C@H](C)CCCc3cccnc3)cc2Br)cc1OC 10.1021/jm00128a025
13557475 208469 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 372 6 1 5 3.0 O=C(NCCCCc1cccnc1)c1ccc2nc3ccccc3c(=O)n2c1 10.1021/jm00397a034
CHEMBL60625 208469 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 372 6 1 5 3.0 O=C(NCCCCc1cccnc1)c1ccc2nc3ccccc3c(=O)n2c1 10.1021/jm00397a034
44283777 140352 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 339 5 0 5 3.3 COc1ccc(C2CCC(OCC#Cc3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
CHEMBL37116 140352 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 339 5 0 5 3.3 COc1ccc(C2CCC(OCC#Cc3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
44284380 130085 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 337 6 0 5 4.0 Cc1nc2cnccc2n1CCCOC1CCC(c2ccccc2)O1 10.1016/S0960-894X(00)80006-2
CHEMBL36154 130085 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 337 6 0 5 4.0 Cc1nc2cnccc2n1CCCOC1CCC(c2ccccc2)O1 10.1016/S0960-894X(00)80006-2
9971461 211782 6 None - 0 Human 4.7 pIC50 = 4.7 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 290 1 0 4 3.0 C1=C(c2ccc3c(c2)OCO3)N2CCN=C2c2ccccc21 10.1021/jm00002a004
CHEMBL76778 211782 6 None - 0 Human 4.7 pIC50 = 4.7 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 290 1 0 4 3.0 C1=C(c2ccc3c(c2)OCO3)N2CCN=C2c2ccccc21 10.1021/jm00002a004
10470867 174700 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Compound were tested for the inhibition of [3H]PAF binding to human platelets.Compound were tested for the inhibition of [3H]PAF binding to human platelets.
ChEMBL 314 1 0 2 4.3 FC(F)(F)c1cccc(C2=Cc3ccccc3C3=NCCN23)c1 10.1021/jm00002a004
CHEMBL431400 174700 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Compound were tested for the inhibition of [3H]PAF binding to human platelets.Compound were tested for the inhibition of [3H]PAF binding to human platelets.
ChEMBL 314 1 0 2 4.3 FC(F)(F)c1cccc(C2=Cc3ccccc3C3=NCCN23)c1 10.1021/jm00002a004
10604738 86281 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 698 15 2 9 8.1 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCSc1c(F)c(F)cc(F)c1F 10.1021/jm980046r
CHEMBL2113725 86281 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 698 15 2 9 8.1 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCSc1c(F)c(F)cc(F)c1F 10.1021/jm980046r
14347334 108023 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 442 11 1 4 5.2 COc1cccc(C(=C/C=C/C(=O)NCCCCc2cccnc2)c2cccc(OC)c2)c1 10.1021/jm00128a026
CHEMBL296149 108023 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 442 11 1 4 5.2 COc1cccc(C(=C/C=C/C(=O)NCCCCc2cccnc2)c2cccc(OC)c2)c1 10.1021/jm00128a026
14347380 205167 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 426 10 1 3 5.6 COc1ccc(/C(=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)c2ccccc2)cc1 10.1021/jm00128a026
CHEMBL57676 205167 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 426 10 1 3 5.6 COc1ccc(/C(=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)c2ccccc2)cc1 10.1021/jm00128a026
14851873 105728 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 495 2 0 7 5.0 Cc1nnc2n1-c1sc(C#CCn3c(=O)ccc4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL279665 105728 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 495 2 0 7 5.0 Cc1nnc2n1-c1sc(C#CCn3c(=O)ccc4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
10668473 56205 1 None - 0 Human 8.6 pIC50 = 8.6 Binding
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
ChEMBL 396 6 1 5 2.6 O=C([C@@H]1CSC(c2cccnc2)N1)N1CCN(CCCc2ccccc2)CC1 10.1016/S0960-894X(01)81205-1
CHEMBL156461 56205 1 None - 0 Human 8.6 pIC50 = 8.6 Binding
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
ChEMBL 396 6 1 5 2.6 O=C([C@@H]1CSC(c2cccnc2)N1)N1CCN(CCCc2ccccc2)CC1 10.1016/S0960-894X(01)81205-1
10746928 86283 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 660 15 2 9 8.2 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCSc1ccc(Cl)cc1 10.1021/jm980046r
CHEMBL2113727 86283 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 660 15 2 9 8.2 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCSc1ccc(Cl)cc1 10.1021/jm980046r
15084160 106878 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 460 4 0 6 5.4 Cc1nnc2n1-c1sc(CCc3ccc4c(c3)CCO4)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL287465 106878 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 460 4 0 6 5.4 Cc1nnc2n1-c1sc(CCc3ccc4c(c3)CCO4)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
15084159 107111 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 458 4 0 5 5.9 Cc1nnc2n1-c1sc(CCc3ccc4c(c3)CCC4)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL289463 107111 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 458 4 0 5 5.9 Cc1nnc2n1-c1sc(CCc3ccc4c(c3)CCC4)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
14851899 117251 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 410 1 0 5 4.9 Cc1nnc2n1-c1sc(C#C[Si](C)(C)C)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL32475 117251 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 410 1 0 5 4.9 Cc1nnc2n1-c1sc(C#C[Si](C)(C)C)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
6917920 108226 2 None -1 2 Guinea pig 7.7 pIC50 = 7.7 Binding
Inhibition of PAF receptor binding to rabbit platelet plasma membranesInhibition of PAF receptor binding to rabbit platelet plasma membranes
ChEMBL 404 8 0 7 4.3 COc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OC 10.1021/jm00160a020
CHEMBL297624 108226 2 None -1 2 Guinea pig 7.7 pIC50 = 7.7 Binding
Inhibition of PAF receptor binding to rabbit platelet plasma membranesInhibition of PAF receptor binding to rabbit platelet plasma membranes
ChEMBL 404 8 0 7 4.3 COc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OC 10.1021/jm00160a020
44284535 125528 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 427 9 0 8 4.1 COc1cc(C2CCC(OCCCn3c(C)nc4cnccc43)O2)cc(OC)c1OC 10.1016/S0960-894X(00)80006-2
CHEMBL34182 125528 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 427 9 0 8 4.1 COc1cc(C2CCC(OCCCn3c(C)nc4cnccc43)O2)cc(OC)c1OC 10.1016/S0960-894X(00)80006-2
14347392 168888 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 432 10 1 3 6.1 COc1ccc(/C(=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)C2CCCCC2)cc1 10.1021/jm00128a026
CHEMBL416124 168888 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 432 10 1 3 6.1 COc1ccc(/C(=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)C2CCCCC2)cc1 10.1021/jm00128a026
14347393 200212 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 432 10 1 3 6.1 COc1ccc(/C(=C\C=C\C(=O)N[C@H](C)CCCc2cccnc2)C2CCCCC2)cc1 10.1021/jm00128a026
CHEMBL52616 200212 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 432 10 1 3 6.1 COc1ccc(/C(=C\C=C\C(=O)N[C@H](C)CCCc2cccnc2)C2CCCCC2)cc1 10.1021/jm00128a026
14347330 200984 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 418 9 1 2 5.5 O=C(/C=C/C=C(c1cccc(F)c1)c1cccc(F)c1)NCCCCc1cccnc1 10.1021/jm00128a026
CHEMBL52834 200984 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 418 9 1 2 5.5 O=C(/C=C/C=C(c1cccc(F)c1)c1cccc(F)c1)NCCCCc1cccnc1 10.1021/jm00128a026
14570083 196098 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 374 8 1 3 4.9 COc1cccc(-c2ccc(C(=O)N[C@H](C)CCCc3cccnc3)cc2)c1 10.1021/jm00128a025
CHEMBL51238 196098 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 374 8 1 3 4.9 COc1cccc(-c2ccc(C(=O)N[C@H](C)CCCc3cccnc3)cc2)c1 10.1021/jm00128a025
14851837 79652 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 491 2 0 6 4.2 Cc1nnc2n1-c1ccc(C#CCN3C(=O)c4ccccc4C3=O)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20033 79652 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 491 2 0 6 4.2 Cc1nnc2n1-c1ccc(C#CCN3C(=O)c4ccccc4C3=O)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14894668 105727 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 475 2 0 5 4.4 Cc1nnc2n1-c1ccc(C#CCN3C(=O)CCc4ccccc43)cc1C(c1ccccc1F)=NC2 10.1021/jm00107a048
CHEMBL279664 105727 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 475 2 0 5 4.4 Cc1nnc2n1-c1ccc(C#CCN3C(=O)CCc4ccccc43)cc1C(c1ccccc1F)=NC2 10.1021/jm00107a048
13557487 40026 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 443 9 1 6 4.3 CC(C)c1ccc2nc3ccc(C(=O)NCCCCCCc4cncnc4)cn3c(=O)c2c1 10.1021/jm00397a034
CHEMBL141825 40026 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 443 9 1 6 4.3 CC(C)c1ccc2nc3ccc(C(=O)NCCCCCCc4cncnc4)cn3c(=O)c2c1 10.1021/jm00397a034
1859 7223 62 None -2 2 Human 6.7 pIC50 = 6.7 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00108a031
1860 7223 62 None -2 2 Human 6.7 pIC50 = 6.7 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00108a031
65889 7223 62 None -2 2 Human 6.7 pIC50 = 6.7 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00108a031
CHEMBL280164 7223 62 None -2 2 Human 6.7 pIC50 = 6.7 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00108a031
44283979 107042 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 351 6 0 3 5.2 Clc1ccc([C@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1Cl 10.1016/S0960-894X(00)80005-0
CHEMBL288849 107042 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 351 6 0 3 5.2 Clc1ccc([C@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1Cl 10.1016/S0960-894X(00)80005-0
122159 108131 19 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
Inhibition concentration required to block 50% of the specific [3H]PAF binding, obtained from Chiralpak column at low temperatures.Inhibition concentration required to block 50% of the specific [3H]PAF binding, obtained from Chiralpak column at low temperatures.
ChEMBL 356 6 0 5 3.8 C=CCC1=C[C@@]2(OC)C(=CC1=O)O[C@H](c1ccc(OC)c(OC)c1)[C@H]2C 10.1021/jm00384a023
CHEMBL296958 108131 19 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
Inhibition concentration required to block 50% of the specific [3H]PAF binding, obtained from Chiralpak column at low temperatures.Inhibition concentration required to block 50% of the specific [3H]PAF binding, obtained from Chiralpak column at low temperatures.
ChEMBL 356 6 0 5 3.8 C=CCC1=C[C@@]2(OC)C(=CC1=O)O[C@H](c1ccc(OC)c(OC)c1)[C@H]2C 10.1021/jm00384a023
44299968 204054 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
Inhibition of PAF receptor binding to rabbit platelet plasma membranesInhibition of PAF receptor binding to rabbit platelet plasma membranes
ChEMBL 372 6 0 5 4.8 COc1ccc(C2O[C@@H](c3ccc(OC)c(OC)c3)[C@@H](C)[C@H]2C)cc1OC 10.1021/jm00160a020
CHEMBL56856 204054 0 None - 0 Guinea pig 6.7 pIC50 = 6.7 Binding
Inhibition of PAF receptor binding to rabbit platelet plasma membranesInhibition of PAF receptor binding to rabbit platelet plasma membranes
ChEMBL 372 6 0 5 4.8 COc1ccc(C2O[C@@H](c3ccc(OC)c(OC)c3)[C@@H](C)[C@H]2C)cc1OC 10.1021/jm00160a020
1859 7223 62 None -2 2 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00128a026
1860 7223 62 None -2 2 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00128a026
65889 7223 62 None -2 2 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00128a026
CHEMBL280164 7223 62 None -2 2 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00128a026
14347358 195221 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 456 11 1 4 5.6 COc1ccc(C(=C/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
CHEMBL50244 195221 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 456 11 1 4 5.6 COc1ccc(C(=C/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
14570086 197787 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 358 7 1 2 5.1 Cc1ccc(-c2ccc(C(=O)NCCCCc3cccnc3)cc2)cc1C 10.1021/jm00128a025
CHEMBL51867 197787 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 358 7 1 2 5.1 Cc1ccc(-c2ccc(C(=O)NCCCCc3cccnc3)cc2)cc1C 10.1021/jm00128a025
14570097 201499 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 449 10 1 6 4.8 COc1ccc(-c2ccc(C(=O)N[C@H](C)CCCc3cccnc3)cc2[N+](=O)[O-])cc1OC 10.1021/jm00128a025
CHEMBL53482 201499 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 449 10 1 6 4.8 COc1ccc(-c2ccc(C(=O)N[C@H](C)CCCc3cccnc3)cc2[N+](=O)[O-])cc1OC 10.1021/jm00128a025
14570095 201512 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 435 10 1 6 4.4 COc1ccc(-c2ccc(C(=O)NCCCCc3cccnc3)cc2[N+](=O)[O-])cc1OC 10.1021/jm00128a025
CHEMBL53534 201512 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 435 10 1 6 4.4 COc1ccc(-c2ccc(C(=O)NCCCCc3cccnc3)cc2[N+](=O)[O-])cc1OC 10.1021/jm00128a025
14570093 201545 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 466 10 1 4 6.2 COc1cccc(-c2ccc(C(=O)NCCCCc3cccnc3)cc2-c2cccc(OC)c2)c1 10.1021/jm00128a025
CHEMBL53808 201545 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 466 10 1 4 6.2 COc1cccc(-c2ccc(C(=O)NCCCCc3cccnc3)cc2-c2cccc(OC)c2)c1 10.1021/jm00128a025
1859 7223 62 None -2 2 Human 6.7 pIC50 = 6.7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00107a048
1860 7223 62 None -2 2 Human 6.7 pIC50 = 6.7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00107a048
65889 7223 62 None -2 2 Human 6.7 pIC50 = 6.7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00107a048
CHEMBL280164 7223 62 None -2 2 Human 6.7 pIC50 = 6.7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00107a048
14851920 105655 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 529 2 0 5 5.1 O=C1CCc2ccccc2N1CC#Cc1ccc2c(c1)C(c1ccccc1F)=NCc1nnc(C(F)(F)F)n1-2 10.1021/jm00107a048
CHEMBL279084 105655 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 529 2 0 5 5.1 O=C1CCc2ccccc2N1CC#Cc1ccc2c(c1)C(c1ccccc1F)=NCc1nnc(C(F)(F)F)n1-2 10.1021/jm00107a048
44284130 145186 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 313 7 0 4 3.9 COc1ccc([C@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1 10.1016/S0960-894X(00)80005-0
CHEMBL37735 145186 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 313 7 0 4 3.9 COc1ccc([C@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1 10.1016/S0960-894X(00)80005-0
10594020 113693 0 None - 0 Guinea pig 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 350 4 1 5 3.0 COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CC[C@H](O)[C@@H]2CCC1=CCOC1=O 10.1021/jm970569j
CHEMBL314708 113693 0 None - 0 Guinea pig 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 350 4 1 5 3.0 COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CC[C@H](O)[C@@H]2CCC1=CCOC1=O 10.1021/jm970569j
10831597 213386 0 None - 0 Guinea pig 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 348 4 0 4 4.3 C=C1CCC2[C@@](C)(C(=O)OC)CCC[C@]2(C)[C@H]1CCC1CCOC1=O 10.1021/jm970569j
CHEMBL89018 213386 0 None - 0 Guinea pig 5.7 pIC50 = 5.7 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 348 4 0 4 4.3 C=C1CCC2[C@@](C)(C(=O)OC)CCC[C@]2(C)[C@H]1CCC1CCOC1=O 10.1021/jm970569j
44284483 145480 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 458 8 0 6 5.8 COc1ccc(C2CCC(OCc3ccc(Cn4c(C)nc5ccccc54)cc3)O2)cc1OC 10.1016/S0960-894X(00)80006-2
CHEMBL37792 145480 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 458 8 0 6 5.8 COc1ccc(C2CCC(OCc3ccc(Cn4c(C)nc5ccccc54)cc3)O2)cc1OC 10.1016/S0960-894X(00)80006-2
10532787 86279 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 704 15 2 9 8.3 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCSc1ccc(Br)cc1 10.1021/jm980046r
CHEMBL2113723 86279 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 704 15 2 9 8.3 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCSc1ccc(Br)cc1 10.1021/jm980046r
44296856 108743 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 366 7 1 2 4.8 O=C(NCCCCc1cccnc1)c1ccc(-c2cccc(F)c2)c(F)c1 10.1021/jm00128a025
CHEMBL301388 108743 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 366 7 1 2 4.8 O=C(NCCCCc1cccnc1)c1ccc(-c2cccc(F)c2)c(F)c1 10.1021/jm00128a025
10519896 113861 0 None - 0 Guinea pig 4.7 pIC50 = 4.7 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 322 6 3 3 3.4 C=C1CCC2[C@@](C)(CO)CCC[C@]2(C)[C@H]1CC/C(=C/CO)CO 10.1021/jm970569j
CHEMBL315854 113861 0 None - 0 Guinea pig 4.7 pIC50 = 4.7 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 322 6 3 3 3.4 C=C1CCC2[C@@](C)(CO)CCC[C@]2(C)[C@H]1CC/C(=C/CO)CO 10.1021/jm970569j
10508960 86278 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 704 15 2 9 8.3 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCSc1cccc(Br)c1 10.1021/jm980046r
CHEMBL2113722 86278 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 704 15 2 9 8.3 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCSc1cccc(Br)c1 10.1021/jm980046r
14964714 115399 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 454 7 0 5 5.5 COc1cc(CCc2ccc(C3=Cc4ccccc4C4=NC(C)CN34)cc2)cc(OC)c1OC 10.1021/jm00073a008
CHEMBL320609 115399 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 454 7 0 5 5.5 COc1cc(CCc2ccc(C3=Cc4ccccc4C4=NC(C)CN34)cc2)cc(OC)c1OC 10.1021/jm00073a008
14570098 200220 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 468 9 1 4 5.3 COc1ccc(-c2ccc(C(=O)NCCCCc3cccnc3)cc2Br)cc1OC 10.1021/jm00128a025
CHEMBL52636 200220 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 468 9 1 4 5.3 COc1ccc(-c2ccc(C(=O)NCCCCc3cccnc3)cc2Br)cc1OC 10.1021/jm00128a025
11724601 212241 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 336 1 0 2 5.2 CC(C)(C)c1ccc(C2=Cc3cc(Cl)ccc3C3=NCCN23)cc1 10.1021/jm00002a004
CHEMBL80443 212241 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 336 1 0 2 5.2 CC(C)(C)c1ccc(C2=Cc3cc(Cl)ccc3C3=NCCN23)cc1 10.1021/jm00002a004
10063751 112459 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 306 3 0 4 3.3 COc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1OC 10.1021/jm00002a004
CHEMBL312567 112459 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 306 3 0 4 3.3 COc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1OC 10.1021/jm00002a004
10628536 86277 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 704 15 2 9 8.3 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCSc1ccccc1Br 10.1021/jm980046r
CHEMBL2113721 86277 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 704 15 2 9 8.3 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCSc1ccccc1Br 10.1021/jm980046r
44284128 106391 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 301 6 0 3 4.0 Fc1ccc([C@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1 10.1016/S0960-894X(00)80005-0
CHEMBL284078 106391 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 301 6 0 3 4.0 Fc1ccc([C@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1 10.1016/S0960-894X(00)80005-0
44322316 213617 0 None - 0 Guinea pig 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 332 4 1 3 4.1 C=C1CCC2[C@@](C)(C(=O)O)CCC[C@]2(C)[C@H]1CCC1=CCOC1=O 10.1021/jm970569j
CHEMBL90504 213617 0 None - 0 Guinea pig 4.6 pIC50 = 4.6 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 332 4 1 3 4.1 C=C1CCC2[C@@](C)(C(=O)O)CCC[C@]2(C)[C@H]1CCC1=CCOC1=O 10.1021/jm970569j
44399185 130841 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor in human plateletInhibition of [3H]PAF binding to platelet activating factor receptor in human platelet
ChEMBL 350 0 2 5 2.3 C/C1=C\CC[C@]2(C)O[C@@H]3C[C@@H](C)[C@](C)(CC1)[C@]14CO[C@](O)([C@H]2O)[C@]31O4 10.1016/j.bmcl.2005.04.048
CHEMBL363216 130841 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor in human plateletInhibition of [3H]PAF binding to platelet activating factor receptor in human platelet
ChEMBL 350 0 2 5 2.3 C/C1=C\CC[C@]2(C)O[C@@H]3C[C@@H](C)[C@](C)(CC1)[C@]14CO[C@](O)([C@H]2O)[C@]31O4 10.1016/j.bmcl.2005.04.048
6917920 108226 2 None -1 2 Guinea pig 7.6 pIC50 = 7.6 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 404 8 0 7 4.3 COc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OC 10.1021/jm950640q
CHEMBL297624 108226 2 None -1 2 Guinea pig 7.6 pIC50 = 7.6 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 404 8 0 7 4.3 COc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OC 10.1021/jm950640q
44329214 214754 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 450 12 1 4 6.6 CCCCCc1c(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)sc2cc(OC)ccc12 10.1021/jm00172a029
CHEMBL97176 214754 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 450 12 1 4 6.6 CCCCCc1c(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)sc2cc(OC)ccc12 10.1021/jm00172a029
122159 108131 19 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Inhibitor concentration required to block 50 %of the specific [3H]PAF binding to rabbit platelet membranes.Inhibitor concentration required to block 50 %of the specific [3H]PAF binding to rabbit platelet membranes.
ChEMBL 356 6 0 5 3.8 C=CCC1=C[C@@]2(OC)C(=CC1=O)O[C@H](c1ccc(OC)c(OC)c1)[C@H]2C 10.1021/jm00384a023
CHEMBL296958 108131 19 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
Inhibitor concentration required to block 50 %of the specific [3H]PAF binding to rabbit platelet membranes.Inhibitor concentration required to block 50 %of the specific [3H]PAF binding to rabbit platelet membranes.
ChEMBL 356 6 0 5 3.8 C=CCC1=C[C@@]2(OC)C(=CC1=O)O[C@H](c1ccc(OC)c(OC)c1)[C@H]2C 10.1021/jm00384a023
10723685 86290 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 736 15 2 10 7.0 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCS(=O)(=O)c1ccccc1Br 10.1021/jm980046r
CHEMBL2113733 86290 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 736 15 2 10 7.0 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCS(=O)(=O)c1ccccc1Br 10.1021/jm980046r
44372435 60421 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 532 12 2 8 6.1 CCCOc1c(NC(=O)N(O)C(C)CC)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
CHEMBL160290 60421 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 532 12 2 8 6.1 CCCOc1c(NC(=O)N(O)C(C)CC)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
14347405 201330 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 364 9 1 3 4.6 COc1ccc(/C(C)=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)cc1 10.1021/jm00128a026
CHEMBL52966 201330 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 364 9 1 3 4.6 COc1ccc(/C(C)=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)cc1 10.1021/jm00128a026
44284580 126030 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 397 8 0 7 4.0 COc1ccc([C@@H]2CC[C@@H](OCCCn3c(C)nc4cnccc43)O2)cc1OC 10.1016/S0960-894X(00)80006-2
CHEMBL34361 126030 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 397 8 0 7 4.0 COc1ccc([C@@H]2CC[C@@H](OCCCn3c(C)nc4cnccc43)O2)cc1OC 10.1016/S0960-894X(00)80006-2
14347367 107780 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 430 10 1 3 5.4 COc1cccc(/C(=C\C=C\C(=O)NCCCCc2cccnc2)c2cccc(F)c2)c1 10.1021/jm00128a026
CHEMBL294387 107780 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 430 10 1 3 5.4 COc1cccc(/C(=C\C=C\C(=O)NCCCCc2cccnc2)c2cccc(F)c2)c1 10.1021/jm00128a026
14347340 201377 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 450 9 1 2 6.5 O=C(/C=C/C=C(c1cccc(Cl)c1)c1cccc(Cl)c1)NCCCCc1cccnc1 10.1021/jm00128a026
CHEMBL53149 201377 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 450 9 1 2 6.5 O=C(/C=C/C=C(c1cccc(Cl)c1)c1cccc(Cl)c1)NCCCCc1cccnc1 10.1021/jm00128a026
14347337 201654 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 442 11 1 4 5.2 COc1ccc(C(=C/C=C/C(=O)NCCCCc2cccnc2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
CHEMBL54029 201654 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 442 11 1 4 5.2 COc1ccc(C(=C/C=C/C(=O)NCCCCc2cccnc2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
44273467 83572 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 557 4 0 8 4.7 COc1cc2c(cc1OC)C(=O)N(CC#Cc1cc3c(s1)-n1c(C)nnc1CN=C3c1ccccc1Cl)CC2 10.1021/jm00107a048
CHEMBL20691 83572 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 557 4 0 8 4.7 COc1cc2c(cc1OC)C(=O)N(CC#Cc1cc3c(s1)-n1c(C)nnc1CN=C3c1ccccc1Cl)CC2 10.1021/jm00107a048
14851892 105595 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 545 2 0 7 6.2 Cc1nnc2n1-c1sc(C#CCn3c4ccccc4c(=O)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL278635 105595 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 545 2 0 7 6.2 Cc1nnc2n1-c1sc(C#CCn3c4ccccc4c(=O)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14851915 106142 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 561 2 1 8 5.7 Cc1nnc2n1-c1sc(C#CCn3c(=O)c4ccccc4c4ccccc43)cc1C(c1ccccc1Cl)=NC2O 10.1021/jm00107a048
CHEMBL282495 106142 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 561 2 1 8 5.7 Cc1nnc2n1-c1sc(C#CCn3c(=O)c4ccccc4c4ccccc43)cc1C(c1ccccc1Cl)=NC2O 10.1021/jm00107a048
13557496 203628 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 400 6 1 5 3.6 Cc1cc2nc3ccc(C(=O)NCCCCc4cccnc4)cn3c(=O)c2cc1C 10.1021/jm00397a034
CHEMBL56588 203628 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 400 6 1 5 3.6 Cc1cc2nc3ccc(C(=O)NCCCCc4cccnc4)cn3c(=O)c2cc1C 10.1021/jm00397a034
13557504 205346 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 428 7 1 5 4.5 CC(CCCc1cccnc1)NC(=O)c1ccc2nc3ccc(C(C)C)cc3c(=O)n2c1 10.1021/jm00397a034
CHEMBL57825 205346 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 428 7 1 5 4.5 CC(CCCc1cccnc1)NC(=O)c1ccc2nc3ccc(C(C)C)cc3c(=O)n2c1 10.1021/jm00397a034
14851905 106531 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 415 1 0 6 4.4 Cc1nnc2n1-c1sc(C#Cc3ccccn3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL285035 106531 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 415 1 0 6 4.4 Cc1nnc2n1-c1sc(C#Cc3ccccn3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
15965493 213571 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 346 4 0 4 4.2 C=C1CCC2[C@@](C)(C(=O)OC)CCC[C@]2(C)[C@H]1CCC1=CCOC1=O 10.1021/jm970569j
CHEMBL90271 213571 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 346 4 0 4 4.2 C=C1CCC2[C@@](C)(C(=O)OC)CCC[C@]2(C)[C@H]1CCC1=CCOC1=O 10.1021/jm970569j
14547300 201668 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 444 11 1 5 4.4 COc1ccc(C(=C/C=C/C(=O)NCCOCc2cccnc2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
CHEMBL54068 201668 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 444 11 1 5 4.4 COc1ccc(C(=C/C=C/C(=O)NCCOCc2cccnc2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
44284397 106771 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 361 8 0 7 3.2 COc1ccc(C2CCC(OCCCn3c(C)nnc3C)O2)cc1OC 10.1016/S0960-894X(00)80006-2
CHEMBL286696 106771 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 361 8 0 7 3.2 COc1ccc(C2CCC(OCCCn3c(C)nnc3C)O2)cc1OC 10.1016/S0960-894X(00)80006-2
14347351 108660 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 432 9 1 2 5.9 C[C@H](CCCc1cccnc1)NC(=O)/C=C/C=C(c1ccc(F)cc1)c1ccc(F)cc1 10.1021/jm00128a026
CHEMBL300742 108660 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 432 9 1 2 5.9 C[C@H](CCCc1cccnc1)NC(=O)/C=C/C=C(c1ccc(F)cc1)c1ccc(F)cc1 10.1021/jm00128a026
14347362 178118 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 424 9 1 2 6.2 Cc1ccc(C(=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)c2ccc(C)cc2)cc1 10.1021/jm00128a026
CHEMBL446140 178118 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 424 9 1 2 6.2 Cc1ccc(C(=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)c2ccc(C)cc2)cc1 10.1021/jm00128a026
14347349 201321 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 432 9 1 2 5.9 C[C@@H](CCCc1cccnc1)NC(=O)/C=C/C=C(c1cccc(F)c1)c1cccc(F)c1 10.1021/jm00128a026
CHEMBL52933 201321 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 432 9 1 2 5.9 C[C@@H](CCCc1cccnc1)NC(=O)/C=C/C=C(c1cccc(F)c1)c1cccc(F)c1 10.1021/jm00128a026
14347435 201684 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 476 9 1 4 6.3 COc1ccc(C(=C/C=C/C(=O)Nc2ccc(Cc3cccnc3)cc2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
CHEMBL54106 201684 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 476 9 1 4 6.3 COc1ccc(C(=C/C=C/C(=O)Nc2ccc(Cc3cccnc3)cc2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
14851929 80401 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 559 2 0 7 6.7 Cc1nnc2n1-c1sc(C#CCn3c(=O)c4ccccc4c4ccccc43)cc1C(c1ccccc1Cl)=NC2C 10.1021/jm00107a048
CHEMBL20178 80401 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 559 2 0 7 6.7 Cc1nnc2n1-c1sc(C#CCn3c(=O)c4ccccc4c4ccccc43)cc1C(c1ccccc1Cl)=NC2C 10.1021/jm00107a048
13557456 169965 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 386 5 1 5 3.3 CC(C)c1ccc2nc3ccc(C(=O)NCCc4cccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
CHEMBL418141 169965 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 386 5 1 5 3.3 CC(C)c1ccc2nc3ccc(C(=O)NCCc4cccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
44283822 146125 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 351 6 0 3 5.2 Clc1ccc([C@@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1Cl 10.1016/S0960-894X(00)80005-0
CHEMBL37929 146125 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 351 6 0 3 5.2 Clc1ccc([C@@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1Cl 10.1016/S0960-894X(00)80005-0
44283860 107305 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 315 6 0 5 3.5 COc1ccc(C2CCC(OCc3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
CHEMBL291293 107305 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 315 6 0 5 3.5 COc1ccc(C2CCC(OCc3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
44372545 55531 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 532 10 2 8 6.1 CCCOc1c(NC(=O)N(O)C(C)(C)C)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
CHEMBL155851 55531 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 532 10 2 8 6.1 CCCOc1c(NC(=O)N(O)C(C)(C)C)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
10714683 47518 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 378 2 0 5 4.7 COC(=O)OC[C@H]1[C@H]2CC[C@@H](C)[C@]1(C)CC/C(C)=C/CC[C@@]1(C)O[C@@H]1C2=O 10.1021/jm950640q
CHEMBL148491 47518 0 None - 0 Guinea pig 7.6 pIC50 = 7.6 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 378 2 0 5 4.7 COC(=O)OC[C@H]1[C@H]2CC[C@@H](C)[C@]1(C)CC/C(C)=C/CC[C@@]1(C)O[C@@H]1C2=O 10.1021/jm950640q
44329180 114748 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 461 13 1 4 6.2 CCCCCc1c(/C=C/C(=O)N[C@@H](CC)CCCc2cccnc2)n(C)c2cc(OC)ccc12 10.1021/jm00172a029
CHEMBL319384 114748 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 461 13 1 4 6.2 CCCCCc1c(/C=C/C(=O)N[C@@H](CC)CCCc2cccnc2)n(C)c2cc(OC)ccc12 10.1021/jm00172a029
15084136 106868 1 None - 0 Human 6.6 pIC50 = 6.6 Binding
Compound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog plateletsCompound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets
ChEMBL 451 1 0 7 2.9 Cc1nnc2n1-c1sc(C#CC(=O)N3CCOCC3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL287380 106868 1 None - 0 Human 6.6 pIC50 = 6.6 Binding
Compound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog plateletsCompound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets
ChEMBL 451 1 0 7 2.9 Cc1nnc2n1-c1sc(C#CC(=O)N3CCOCC3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
9997895 213090 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 348 4 0 5 3.2 COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CCC(=O)[C@@H]2CCC1=CCOC1=O 10.1021/jm970569j
CHEMBL87164 213090 0 None - 0 Guinea pig 6.6 pIC50 = 6.6 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 348 4 0 5 3.2 COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CCC(=O)[C@@H]2CCC1=CCOC1=O 10.1021/jm970569j
10807790 174589 0 None - 0 Guinea pig 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 350 4 0 5 3.3 COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CCC(=O)[C@@H]2CCC1CCOC1=O 10.1021/jm970569j
CHEMBL430638 174589 0 None - 0 Guinea pig 5.6 pIC50 = 5.6 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 350 4 0 5 3.3 COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CCC(=O)[C@@H]2CCC1CCOC1=O 10.1021/jm970569j
14347352 108529 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 432 9 1 2 5.9 C[C@@H](CCCc1cccnc1)NC(=O)/C=C/C=C(c1ccc(F)cc1)c1ccc(F)cc1 10.1021/jm00128a026
CHEMBL299780 108529 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 432 9 1 2 5.9 C[C@@H](CCCc1cccnc1)NC(=O)/C=C/C=C(c1ccc(F)cc1)c1ccc(F)cc1 10.1021/jm00128a026
23214200 55677 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 558 11 2 8 6.7 CCCOc1c(NC(=O)N(O)C2CCCCC2)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
CHEMBL155975 55677 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 558 11 2 8 6.7 CCCOc1c(NC(=O)N(O)C2CCCCC2)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
71716054 92776 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for anti-platelet activating factor potencyCompound was evaluated for anti-platelet activating factor potency
ChEMBL 548 3 2 10 1.5 C[C@@H]1C(=O)O[C@H]2[C@H](OCc3ccc(Cl)cc3)C34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6O)O[C@@]4(C(=O)O5)[C@@]12O 10.1016/s0960-894x(98)00205-4
CHEMBL2304168 92776 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Compound was evaluated for anti-platelet activating factor potencyCompound was evaluated for anti-platelet activating factor potency
ChEMBL 548 3 2 10 1.5 C[C@@H]1C(=O)O[C@H]2[C@H](OCc3ccc(Cl)cc3)C34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6O)O[C@@]4(C(=O)O5)[C@@]12O 10.1016/s0960-894x(98)00205-4
14570080 168100 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 360 8 1 3 4.5 COc1cccc(-c2ccc(C(=O)NCCCCc3cccnc3)cc2)c1 10.1021/jm00128a025
CHEMBL412441 168100 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 360 8 1 3 4.5 COc1cccc(-c2ccc(C(=O)NCCCCc3cccnc3)cc2)c1 10.1021/jm00128a025
10066158 111671 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 345 3 0 4 3.1 C1=C(c2ccc(CN3CCOCC3)cc2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
CHEMBL311227 111671 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 345 3 0 4 3.1 C1=C(c2ccc(CN3CCOCC3)cc2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
10628732 86289 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 730 15 2 10 6.7 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCS(=O)(=O)c1c(F)c(F)cc(F)c1F 10.1021/jm980046r
CHEMBL2113732 86289 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 730 15 2 10 6.7 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCS(=O)(=O)c1c(F)c(F)cc(F)c1F 10.1021/jm980046r
18639456 215215 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 460 12 1 4 6.1 CCCCc1c(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)cc(OC)c2ccc(OC)cc12 10.1021/jm00172a029
CHEMBL99924 215215 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 460 12 1 4 6.1 CCCCc1c(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)cc(OC)c2ccc(OC)cc12 10.1021/jm00172a029
44284532 126280 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 401 7 0 6 4.7 COc1ccc(C2CCC(OCCCn3c(C)nc4cnccc43)O2)cc1Cl 10.1016/S0960-894X(00)80006-2
CHEMBL34548 126280 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 401 7 0 6 4.7 COc1ccc(C2CCC(OCCCn3c(C)nc4cnccc43)O2)cc1Cl 10.1016/S0960-894X(00)80006-2
14851881 80189 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 444 3 0 6 5.1 Cc1nnc2n1-c1sc(C#CCOc3ccccc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20163 80189 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 444 3 0 6 5.1 Cc1nnc2n1-c1sc(C#CCOc3ccccc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14851861 173921 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 483 2 0 6 4.6 Cc1nnc2n1-c1sc(C#CCN3C(=O)Cc4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL429066 173921 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 483 2 0 6 4.6 Cc1nnc2n1-c1sc(C#CCN3C(=O)Cc4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
44372410 60341 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 476 10 3 8 4.6 CCCOc1c(NC(=O)NO)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
CHEMBL160218 60341 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 476 10 3 8 4.6 CCCOc1c(NC(=O)NO)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
10695884 119128 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 474 6 0 5 6.6 Cc1nnc2n1-c1sc(CCc3ccc(CC(C)C)cc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL32942 119128 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 474 6 0 5 6.6 Cc1nnc2n1-c1sc(CCc3ccc(CC(C)C)cc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
14347407 108539 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 378 10 1 3 5.0 CC/C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1021/jm00128a026
CHEMBL299856 108539 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 378 10 1 3 5.0 CC/C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1021/jm00128a026
14547297 201660 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 470 11 1 4 5.9 COc1ccc(C(=C/C=C/C(=O)NC(C)CCCc2cccnc2C)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
CHEMBL54046 201660 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 470 11 1 4 5.9 COc1ccc(C(=C/C=C/C(=O)NC(C)CCCc2cccnc2C)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
44328857 214967 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 482 10 1 4 5.9 COc1ccc(C2=C(/C=C/C(=O)N[C@@H](C)CCCc3cccnc3)CCc3cc(OC)ccc32)cc1 10.1021/jm00172a029
CHEMBL98401 214967 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 482 10 1 4 5.9 COc1ccc(C2=C(/C=C/C(=O)N[C@@H](C)CCCc3cccnc3)CCc3cc(OC)ccc32)cc1 10.1021/jm00172a029
14347403 197081 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 350 9 1 3 4.2 COc1ccc(/C=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)cc1 10.1021/jm00128a026
CHEMBL51760 197081 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 350 9 1 3 4.2 COc1ccc(/C=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)cc1 10.1021/jm00128a026
44273330 81299 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 555 5 0 9 4.4 Cc1nnc2n1-c1sc(C#CCn3c(=O)n(CCN(C)C)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20293 81299 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 555 5 0 9 4.4 Cc1nnc2n1-c1sc(C#CCn3c(=O)n(CCN(C)C)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14851893 105759 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 613 2 0 7 7.5 Cc1nnc2n1-c1sc(C#CCn3c(=O)c4cc(Cl)ccc4c4ccc(Cl)cc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL279893 105759 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 613 2 0 7 7.5 Cc1nnc2n1-c1sc(C#CCn3c(=O)c4cc(Cl)ccc4c4ccc(Cl)cc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
44284466 170045 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
ChEMBL 397 5 0 4 4.3 Cc1nc2ccccc2n1Cc1ccc(S(=O)(=O)N(C)C2CCCCC2)cc1 10.1016/S0960-894X(01)81205-1
CHEMBL418608 170045 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
ChEMBL 397 5 0 4 4.3 Cc1nc2ccccc2n1Cc1ccc(S(=O)(=O)N(C)C2CCCCC2)cc1 10.1016/S0960-894X(01)81205-1
44372410 60341 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 476 10 3 8 4.6 CCCOc1c(NC(=O)NO)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
CHEMBL160218 60341 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 476 10 3 8 4.6 CCCOc1c(NC(=O)NO)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
2451 117261 30 None - 1 Human 6.5 pIC50 = 6.5 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 392 1 0 5 4.4 Cc1nnc2n1-c1sc(Br)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL32479 117261 30 None - 1 Human 6.5 pIC50 = 6.5 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 392 1 0 5 4.4 Cc1nnc2n1-c1sc(Br)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
15084148 123721 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 496 2 0 5 7.1 Cc1nnc2n1-c1sc(C#Cc3ccc(C4CCCCC4)cc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL33857 123721 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 496 2 0 5 7.1 Cc1nnc2n1-c1sc(C#Cc3ccc(C4CCCCC4)cc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
44283848 106492 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 343 8 0 5 3.9 COc1ccc(C2CCC(OCCCc3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
CHEMBL284773 106492 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 343 8 0 5 3.9 COc1ccc(C2CCC(OCCCc3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
44283998 146301 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 341 7 0 5 4.0 COc1ccc(C2CCC(OC/C=C/c3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
CHEMBL37952 146301 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 341 7 0 5 4.0 COc1ccc(C2CCC(OC/C=C/c3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
14347355 174766 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 456 11 1 4 5.6 COc1cccc(C(=C/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)c2cccc(OC)c2)c1 10.1021/jm00128a026
CHEMBL431923 174766 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 456 11 1 4 5.6 COc1cccc(C(=C/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)c2cccc(OC)c2)c1 10.1021/jm00128a026
14347373 201704 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 444 11 1 5 4.7 COc1ccc(C(=C/C=C/C(=O)NCCCOc2cccnc2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
CHEMBL54163 201704 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 444 11 1 5 4.7 COc1ccc(C(=C/C=C/C(=O)NCCCOc2cccnc2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
44284466 170045 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 397 5 0 4 4.3 Cc1nc2ccccc2n1Cc1ccc(S(=O)(=O)N(C)C2CCCCC2)cc1 10.1016/S0960-894X(00)80006-2
CHEMBL418608 170045 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 397 5 0 4 4.3 Cc1nc2ccccc2n1Cc1ccc(S(=O)(=O)N(C)C2CCCCC2)cc1 10.1016/S0960-894X(00)80006-2
14570085 169114 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 346 7 2 3 4.2 O=C(NCCCCc1cccnc1)c1ccc(-c2cccc(O)c2)cc1 10.1021/jm00128a025
CHEMBL416480 169114 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 346 7 2 3 4.2 O=C(NCCCCc1cccnc1)c1ccc(-c2cccc(O)c2)cc1 10.1021/jm00128a025
14570101 198880 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 420 10 1 5 4.5 COc1ccc(-c2ccc(C(=O)NCCCCc3cccnc3)cc2OC)cc1OC 10.1021/jm00128a025
CHEMBL52031 198880 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 420 10 1 5 4.5 COc1ccc(-c2ccc(C(=O)NCCCCc3cccnc3)cc2OC)cc1OC 10.1021/jm00128a025
14894754 80687 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 461 2 0 6 4.0 Cc1nnc2nc(-c3ccccc3F)c3cc(C#CCN4C(=O)c5ccccc5C4=O)ccc3n12 10.1021/jm00107a048
CHEMBL20196 80687 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 461 2 0 6 4.0 Cc1nnc2nc(-c3ccccc3F)c3cc(C#CCN4C(=O)c5ccccc5C4=O)ccc3n12 10.1021/jm00107a048
44283917 17950 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 358 8 0 4 3.4 COc1ccc([C@@H]2CC[C@@H](OCCCc3ccc[n+](C)c3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
CHEMBL1178599 17950 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 358 8 0 4 3.4 COc1ccc([C@@H]2CC[C@@H](OCCCc3ccc[n+](C)c3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
CHEMBL34063 17950 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 358 8 0 4 3.4 COc1ccc([C@@H]2CC[C@@H](OCCCc3ccc[n+](C)c3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
44283756 168949 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 371 10 0 5 4.7 COc1ccc(C2CCC(OCCCCCc3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
CHEMBL416232 168949 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 371 10 0 5 4.7 COc1ccc(C2CCC(OCCCCCc3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
10734343 118271 0 None - 0 Guinea pig 4.5 pIC50 = 4.5 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 318 4 1 3 4.0 C=C1CCC2[C@@](C)(CO)CCC[C@]2(C)[C@H]1CCC1=CCOC1=O 10.1021/jm970569j
CHEMBL327771 118271 0 None - 0 Guinea pig 4.5 pIC50 = 4.5 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 318 4 1 3 4.0 C=C1CCC2[C@@](C)(CO)CCC[C@]2(C)[C@H]1CCC1=CCOC1=O 10.1021/jm970569j
44366271 128414 0 None - 0 Guinea pig 4.5 pIC50 = 4.5 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 336 1 1 4 3.1 C[C@@H]1CC[C@H]2C(=O)[C@H]3O[C@]3(C)CC[C@@H]3O[C@@]3(C)CC[C@]1(C)[C@H]2CO 10.1021/jm950640q
CHEMBL358635 128414 0 None - 0 Guinea pig 4.5 pIC50 = 4.5 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 336 1 1 4 3.1 C[C@@H]1CC[C@H]2C(=O)[C@H]3O[C@]3(C)CC[C@@H]3O[C@@]3(C)CC[C@]1(C)[C@H]2CO 10.1021/jm950640q
10715382 50331 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 389 3 1 5 4.8 C/C1=C\CC[C@@]2(C)O[C@@H]2[C@H](O)[C@@H]2CC[C@@H](C)[C@](C)(CC1)[C@H]2COc1ccon1 10.1021/jm950640q
CHEMBL150892 50331 0 None - 0 Guinea pig 7.5 pIC50 = 7.5 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 389 3 1 5 4.8 C/C1=C\CC[C@@]2(C)O[C@@H]2[C@H](O)[C@@H]2CC[C@@H](C)[C@](C)(CC1)[C@H]2COc1ccon1 10.1021/jm950640q
10381070 211995 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 316 1 0 2 4.9 Cc1ccc2c(c1)C1=NCCN1C(c1ccc(C(C)(C)C)cc1)=C2 10.1021/jm00002a004
CHEMBL78624 211995 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 316 1 0 2 4.9 Cc1ccc2c(c1)C1=NCCN1C(c1ccc(C(C)(C)C)cc1)=C2 10.1021/jm00002a004
9936894 206095 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 532 13 2 8 6.1 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCC 10.1021/jm980046r
CHEMBL59051 206095 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 532 13 2 8 6.1 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCC 10.1021/jm980046r
23214264 126397 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 532 13 2 8 6.1 CCCCN(O)C(=O)Nc1cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCC 10.1016/0960-894X(95)00088-B
CHEMBL346538 126397 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 532 13 2 8 6.1 CCCCN(O)C(=O)Nc1cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCC 10.1016/0960-894X(95)00088-B
44329213 214742 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 432 12 1 3 6.1 CCCCCC1=C(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)Cc2cc(OC)ccc21 10.1021/jm00172a029
CHEMBL97120 214742 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 432 12 1 3 6.1 CCCCCC1=C(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)Cc2cc(OC)ccc21 10.1021/jm00172a029
10833543 46333 0 None - 0 Guinea pig 6.5 pIC50 = 6.5 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 378 3 1 4 4.6 CCC(=O)OC[C@H]1[C@H]2CC[C@@H](C)[C@]1(C)CC/C(C)=C/CC[C@@]1(C)O[C@@H]1[C@@H]2O 10.1021/jm950640q
CHEMBL147337 46333 0 None - 0 Guinea pig 6.5 pIC50 = 6.5 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 378 3 1 4 4.6 CCC(=O)OC[C@H]1[C@H]2CC[C@@H](C)[C@]1(C)CC/C(C)=C/CC[C@@]1(C)O[C@@H]1[C@@H]2O 10.1021/jm950640q
10314059 170859 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 322 2 0 2 4.9 C1=C(c2ccc(-c3ccccc3)cc2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
CHEMBL420943 170859 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 322 2 0 2 4.9 C1=C(c2ccc(-c3ccccc3)cc2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
15084157 174890 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 500 5 0 5 7.5 Cc1nnc2n1-c1sc(CCc3ccc(C4CCCCC4)cc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL432850 174890 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 500 5 0 5 7.5 Cc1nnc2n1-c1sc(CCc3ccc(C4CCCCC4)cc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
14347354 108808 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 456 11 1 4 5.6 COc1cccc(C(=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)c2cccc(OC)c2)c1 10.1021/jm00128a026
CHEMBL301797 108808 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 456 11 1 4 5.6 COc1cccc(C(=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)c2cccc(OC)c2)c1 10.1021/jm00128a026
13557460 205233 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 414 7 1 5 4.1 CC(C)c1ccc2nc3ccc(C(=O)NCCCCc4cccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
CHEMBL57736 205233 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 414 7 1 5 4.1 CC(C)c1ccc2nc3ccc(C(=O)NCCCCc4cccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
145955 203420 5 None - 0 Human 5.5 pIC50 = 5.5 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 403 7 1 6 3.4 CC(C)c1ccc2nc3ccc(C(=O)NCCCCn4ccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
CHEMBL56434 203420 5 None - 0 Human 5.5 pIC50 = 5.5 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 403 7 1 6 3.4 CC(C)c1ccc2nc3ccc(C(=O)NCCCCn4ccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
14964724 11982 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 452 7 0 5 6.3 COc1cc(CCc2ccc(-c3cc4ccccc4c4nc(C)cn34)cc2)cc(OC)c1OC 10.1021/jm00073a008
CHEMBL106163 11982 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 452 7 0 5 6.3 COc1cc(CCc2ccc(-c3cc4ccccc4c4nc(C)cn34)cc2)cc(OC)c1OC 10.1021/jm00073a008
2812 11551 101 None -69 34 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 11551 101 None -69 34 Human 4.5 pIC50 = 4.5 Binding
DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
44273372 84048 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 485 2 0 7 4.2 Cc1nnc2n1-c1sc(I)cc1C(c1cc([N+](=O)[O-])ccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20808 84048 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 485 2 0 7 4.2 Cc1nnc2n1-c1sc(I)cc1C(c1cc([N+](=O)[O-])ccc1Cl)=NC2 10.1021/jm00107a048
2753 126128 67 None - 1 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)
ChEMBL 342 6 1 4 3.9 CN(C(=O)CCCOc1ccc2nc(O)ccc2c1)C1CCCCC1 nan
CHEMBL34431 126128 67 None - 1 Human 5.4 pIC50 = 5.4 Binding
DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)
ChEMBL 342 6 1 4 3.9 CN(C(=O)CCCOc1ccc2nc(O)ccc2c1)C1CCCCC1 nan
13557494 203397 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 402 7 1 6 3.0 COc1ccc2c(=O)n3cc(C(=O)NCCCCc4cccnc4)ccc3nc2c1 10.1021/jm00397a034
CHEMBL56418 203397 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 402 7 1 6 3.0 COc1ccc2c(=O)n3cc(C(=O)NCCCCc4cccnc4)ccc3nc2c1 10.1021/jm00397a034
14851924 81843 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 440 1 0 5 4.2 Cc1nnc2n1-c1sc(I)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL20359 81843 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 440 1 0 5 4.2 Cc1nnc2n1-c1sc(I)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
14851924 81843 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 440 1 0 5 4.2 Cc1nnc2n1-c1sc(I)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20359 81843 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 440 1 0 5 4.2 Cc1nnc2n1-c1sc(I)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
10103 10189 72 None -933 3 Human 5.4 pIC50 = 5.4 Binding
Inhibitory concentration against platelet activating factor receptorInhibitory concentration against platelet activating factor receptor
ChEMBL 415 2 0 3 5.6 Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 10.1021/jm058225d
133017 10189 72 None -933 3 Human 5.4 pIC50 = 5.4 Binding
Inhibitory concentration against platelet activating factor receptorInhibitory concentration against platelet activating factor receptor
ChEMBL 415 2 0 3 5.6 Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 10.1021/jm058225d
2413 10189 72 None -933 3 Human 5.4 pIC50 = 5.4 Binding
Inhibitory concentration against platelet activating factor receptorInhibitory concentration against platelet activating factor receptor
ChEMBL 415 2 0 3 5.6 Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 10.1021/jm058225d
CHEMBL91397 10189 72 None -933 3 Human 5.4 pIC50 = 5.4 Binding
Inhibitory concentration against platelet activating factor receptorInhibitory concentration against platelet activating factor receptor
ChEMBL 415 2 0 3 5.6 Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 10.1021/jm058225d
DB11614 10189 72 None -933 3 Human 5.4 pIC50 = 5.4 Binding
Inhibitory concentration against platelet activating factor receptorInhibitory concentration against platelet activating factor receptor
ChEMBL 415 2 0 3 5.6 Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 10.1021/jm058225d
10265702 212002 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 280 1 0 2 3.9 Clc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
CHEMBL78668 212002 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 280 1 0 2 3.9 Clc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
10700170 86282 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 736 15 2 10 7.0 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCS(=O)(=O)c1ccc(Br)cc1 10.1021/jm980046r
CHEMBL2113726 86282 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 736 15 2 10 7.0 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCS(=O)(=O)c1ccc(Br)cc1 10.1021/jm980046r
15084149 106418 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 454 1 0 5 5.5 Cc1nnc2n1-c1sc(C#Cc3ccc4c(c3)CCC4)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL284280 106418 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 454 1 0 5 5.5 Cc1nnc2n1-c1sc(C#Cc3ccc4c(c3)CCC4)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
23214230 126482 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 504 11 2 8 5.3 CCCOc1c(NC(=O)N(O)CC)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
CHEMBL347382 126482 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 504 11 2 8 5.3 CCCOc1c(NC(=O)N(O)CC)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
10842032 86287 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 656 16 2 10 7.5 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCSc1ccc(OC)cc1 10.1021/jm980046r
CHEMBL2113730 86287 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 656 16 2 10 7.5 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCSc1ccc(OC)cc1 10.1021/jm980046r
14347379 201320 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 426 10 1 3 5.6 COc1ccc(/C(=C\C=C\C(=O)N[C@H](C)CCCc2cccnc2)c2ccccc2)cc1 10.1021/jm00128a026
CHEMBL52925 201320 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 426 10 1 3 5.6 COc1ccc(/C(=C\C=C\C(=O)N[C@H](C)CCCc2cccnc2)c2ccccc2)cc1 10.1021/jm00128a026
14570112 196653 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 460 12 1 4 6.3 CCCCc1cc(C(=O)N[C@H](C)CCCc2cccnc2)ccc1-c1ccc(OC)c(OC)c1 10.1021/jm00128a025
CHEMBL51692 196653 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 460 12 1 4 6.3 CCCCc1cc(C(=O)N[C@H](C)CCCc2cccnc2)ccc1-c1ccc(OC)c(OC)c1 10.1021/jm00128a025
14570105 201342 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 432 10 1 4 5.5 CCc1cc(C(=O)N[C@H](C)CCCc2cccnc2)ccc1-c1ccc(OC)c(OC)c1 10.1021/jm00128a025
CHEMBL53001 201342 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 432 10 1 4 5.5 CCc1cc(C(=O)N[C@H](C)CCCc2cccnc2)ccc1-c1ccc(OC)c(OC)c1 10.1021/jm00128a025
14851885 81202 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 499 2 0 7 5.2 Cc1nnc2n1-c1sc(C#CCN3C(=O)OCc4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20267 81202 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 499 2 0 7 5.2 Cc1nnc2n1-c1sc(C#CCN3C(=O)OCc4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14851890 82210 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 517 2 0 7 4.6 Cc1nnc2n1-c1sc(C#CCN3C(=O)COc4cc(F)ccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20418 82210 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 517 2 0 7 4.6 Cc1nnc2n1-c1sc(C#CCN3C(=O)COc4cc(F)ccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14851875 105804 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 533 2 0 6 5.8 Cc1nnc2n1-c1sc(C#CCN3Cc4cccc5cccc(c45)C3=O)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL280210 105804 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 533 2 0 6 5.8 Cc1nnc2n1-c1sc(C#CCN3Cc4cccc5cccc(c45)C3=O)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
44273429 106289 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 445 3 0 7 4.5 Cc1nnc2n1-c1sc(C#CCOc3cccnc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL283339 106289 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 445 3 0 7 4.5 Cc1nnc2n1-c1sc(C#CCOc3cccnc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
6439060 105421 18 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
ChEMBL 420 13 1 3 6.1 CCCCC/C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1016/S0960-894X(01)81205-1
CHEMBL277245 105421 18 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
ChEMBL 420 13 1 3 6.1 CCCCC/C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1016/S0960-894X(01)81205-1
14964717 12052 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 454 7 0 5 5.5 COc1cc(CCc2ccc(C3=Cc4ccccc4C4=NCCCN34)cc2)cc(OC)c1OC 10.1021/jm00073a008
CHEMBL106521 12052 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 454 7 0 5 5.5 COc1cc(CCc2ccc(C3=Cc4ccccc4C4=NCCCN34)cc2)cc(OC)c1OC 10.1021/jm00073a008
159547 10342 19 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 440 7 0 5 5.1 COc1cc(CCc2ccc(cc2)c2cc3ccccc3c3=NCCn23)cc(c1OC)OC 10.1016/S0960-894X(00)80005-0
1855 10342 19 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 440 7 0 5 5.1 COc1cc(CCc2ccc(cc2)c2cc3ccccc3c3=NCCn23)cc(c1OC)OC 10.1016/S0960-894X(00)80005-0
CHEMBL449395 10342 19 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 440 7 0 5 5.1 COc1cc(CCc2ccc(cc2)c2cc3ccccc3c3=NCCn23)cc(c1OC)OC 10.1016/S0960-894X(00)80005-0
6439060 105421 18 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 420 13 1 3 6.1 CCCCC/C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1021/jm00128a026
CHEMBL277245 105421 18 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 420 13 1 3 6.1 CCCCC/C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1021/jm00128a026
14347397 108603 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 392 10 1 3 5.2 COc1ccc(/C(=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)C(C)C)cc1 10.1021/jm00128a026
CHEMBL300299 108603 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 392 10 1 3 5.2 COc1ccc(/C(=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)C(C)C)cc1 10.1021/jm00128a026
14347368 201334 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 430 10 1 3 5.4 COc1cccc(/C(=C/C=C/C(=O)NCCCCc2cccnc2)c2cccc(F)c2)c1 10.1021/jm00128a026
CHEMBL52971 201334 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 430 10 1 3 5.4 COc1cccc(/C(=C/C=C/C(=O)NCCCCc2cccnc2)c2cccc(F)c2)c1 10.1021/jm00128a026
14347399 214507 1 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 420 13 1 3 6.1 CCCCC/C(=C\C=C\C(=O)N[C@@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1021/jm00172a029
CHEMBL95720 214507 1 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 420 13 1 3 6.1 CCCCC/C(=C\C=C\C(=O)N[C@@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1021/jm00172a029
44328877 214517 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 434 12 1 4 6.1 CCCCCc1c(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)oc2cc(OC)ccc12 10.1021/jm00172a029
CHEMBL95765 214517 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 434 12 1 4 6.1 CCCCCc1c(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)oc2cc(OC)ccc12 10.1021/jm00172a029
14347332 168776 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 418 9 1 2 5.5 O=C(/C=C/C=C(c1ccc(F)cc1)c1ccc(F)cc1)NCCCCc1cccnc1 10.1021/jm00128a026
CHEMBL415940 168776 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 418 9 1 2 5.5 O=C(/C=C/C=C(c1ccc(F)cc1)c1ccc(F)cc1)NCCCCc1cccnc1 10.1021/jm00128a026
14347369 201543 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 442 11 1 4 5.2 COc1ccccc1C(=C/C=C/C(=O)NCCCCc1cccnc1)c1ccccc1OC 10.1021/jm00128a026
CHEMBL53804 201543 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 442 11 1 4 5.2 COc1ccccc1C(=C/C=C/C(=O)NCCCCc1cccnc1)c1ccccc1OC 10.1021/jm00128a026
6439060 105421 18 None - 0 Human 7.4 pIC50 = 7.4 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 420 13 1 3 6.1 CCCCC/C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1021/jm00107a048
CHEMBL277245 105421 18 None - 0 Human 7.4 pIC50 = 7.4 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 420 13 1 3 6.1 CCCCC/C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1021/jm00107a048
71720304 92775 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was evaluated for anti-platelet activating factor potencyCompound was evaluated for anti-platelet activating factor potency
ChEMBL 544 5 2 11 0.8 CC1C(=O)O[C@H]2[C@H](O)C34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6OCOCc3ccccc3)O[C@@]4(C(=O)O5)[C@@]12O 10.1016/s0960-894x(98)00205-4
CHEMBL2304167 92775 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was evaluated for anti-platelet activating factor potencyCompound was evaluated for anti-platelet activating factor potency
ChEMBL 544 5 2 11 0.8 CC1C(=O)O[C@H]2[C@H](O)C34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6OCOCc3ccccc3)O[C@@]4(C(=O)O5)[C@@]12O 10.1016/s0960-894x(98)00205-4
13557507 41300 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 428 7 1 5 4.5 CC(C)c1ccc2nc3ccc(C(=O)N[C@@H](C)CCCc4cccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
CHEMBL142903 41300 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 428 7 1 5 4.5 CC(C)c1ccc2nc3ccc(C(=O)N[C@@H](C)CCCc4cccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
13557454 169911 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 442 9 1 5 4.9 CC(C)c1ccc2nc3ccc(C(=O)NCCCCCCc4cccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
CHEMBL417781 169911 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 442 9 1 5 4.9 CC(C)c1ccc2nc3ccc(C(=O)NCCCCCCc4cccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
44281731 106657 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog plateletsCompound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets
ChEMBL 417 3 0 6 5.2 Cc1nnc2n1-c1sc(/C=C\c3ccccn3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL285926 106657 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Compound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog plateletsCompound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets
ChEMBL 417 3 0 6 5.2 Cc1nnc2n1-c1sc(/C=C\c3ccccn3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
15084161 106721 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 502 4 0 6 6.4 Cc1cc(CCc2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)cc2c1OC(C)(C)C2 10.1021/jm00108a031
CHEMBL286337 106721 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 502 4 0 6 6.4 Cc1cc(CCc2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)cc2c1OC(C)(C)C2 10.1021/jm00108a031
15084151 119112 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 498 1 0 6 6.1 Cc1cc(C#Cc2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)cc2c1OC(C)(C)C2 10.1021/jm00108a031
CHEMBL32932 119112 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 498 1 0 6 6.1 Cc1cc(C#Cc2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)cc2c1OC(C)(C)C2 10.1021/jm00108a031
14547296 201319 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 470 12 1 4 6.0 CC[C@@H](CCCc1cccnc1)NC(=O)/C=C/C=C(c1ccc(OC)cc1)c1ccc(OC)cc1 10.1021/jm00128a026
CHEMBL52924 201319 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 470 12 1 4 6.0 CC[C@@H](CCCc1cccnc1)NC(=O)/C=C/C=C(c1ccc(OC)cc1)c1ccc(OC)cc1 10.1021/jm00128a026
14347364 196674 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 382 9 1 2 5.2 O=C(/C=C\C=C(c1ccccc1)c1ccccc1)NCCCCc1cccnc1 10.1021/jm00128a026
CHEMBL51696 196674 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 382 9 1 2 5.2 O=C(/C=C\C=C(c1ccccc1)c1ccccc1)NCCCCc1cccnc1 10.1021/jm00128a026
14570087 196027 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 390 9 1 4 4.5 COc1ccc(-c2ccc(C(=O)NCCCCc3cccnc3)cc2)cc1OC 10.1021/jm00128a025
CHEMBL51170 196027 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 390 9 1 4 4.5 COc1ccc(-c2ccc(C(=O)NCCCCc3cccnc3)cc2)cc1OC 10.1021/jm00128a025
44284129 106766 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 313 7 0 4 3.9 COc1ccc([C@@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1 10.1016/S0960-894X(00)80005-0
CHEMBL286677 106766 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 313 7 0 4 3.9 COc1ccc([C@@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1 10.1016/S0960-894X(00)80005-0
44283845 106820 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 343 8 0 5 3.9 COc1ccc([C@@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
CHEMBL287004 106820 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 343 8 0 5 3.9 COc1ccc([C@@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
44283766 107280 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 361 6 0 3 4.7 Brc1ccc([C@@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1 10.1016/S0960-894X(00)80005-0
CHEMBL291082 107280 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 361 6 0 3 4.7 Brc1ccc([C@@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1 10.1016/S0960-894X(00)80005-0
44284141 143302 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 301 6 0 3 4.0 Fc1ccc([C@@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1 10.1016/S0960-894X(00)80005-0
CHEMBL37364 143302 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 301 6 0 3 4.0 Fc1ccc([C@@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1 10.1016/S0960-894X(00)80005-0
44322220 113460 0 None - 0 Guinea pig 5.4 pIC50 = 5.4 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 362 5 1 5 3.3 COC(=O)[C@@]1(C)CCC[C@]2(C)C(CCC3=CCOC3=O)=C(CO)CCC12 10.1021/jm970569j
CHEMBL314343 113460 0 None - 0 Guinea pig 5.4 pIC50 = 5.4 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 362 5 1 5 3.3 COC(=O)[C@@]1(C)CCC[C@]2(C)C(CCC3=CCOC3=O)=C(CO)CCC12 10.1021/jm970569j
11779704 170174 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 302 1 0 2 4.6 CC(C)(C)c1cccc(C2=Cc3ccccc3C3=NCCN23)c1 10.1021/jm00002a004
CHEMBL419472 170174 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 302 1 0 2 4.6 CC(C)(C)c1cccc(C2=Cc3ccccc3C3=NCCN23)c1 10.1021/jm00002a004
10427163 211933 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 336 1 0 2 5.2 CC(C)(C)c1ccc(C2=Cc3ccc(Cl)cc3C3=NCCN23)cc1 10.1021/jm00002a004
CHEMBL78137 211933 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 336 1 0 2 5.2 CC(C)(C)c1ccc(C2=Cc3ccc(Cl)cc3C3=NCCN23)cc1 10.1021/jm00002a004
10808647 48295 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 362 2 0 4 4.5 CC(=O)OC[C@H]1[C@H]2CC[C@@H](C)[C@]1(C)CC/C(C)=C/CC[C@@]1(C)O[C@@H]1C2=O 10.1021/jm950640q
CHEMBL149102 48295 0 None - 0 Guinea pig 6.4 pIC50 = 6.4 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 362 2 0 4 4.5 CC(=O)OC[C@H]1[C@H]2CC[C@@H](C)[C@]1(C)CC/C(C)=C/CC[C@@]1(C)O[C@@H]1C2=O 10.1021/jm950640q
15084137 106554 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 483 4 1 9 2.6 Cc1nnc2n1-c1sc(/C(CC(=O)N3CCOCC3)=N\N)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL285199 106554 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 483 4 1 9 2.6 Cc1nnc2n1-c1sc(/C(CC(=O)N3CCOCC3)=N\N)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
15084150 126545 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 456 1 0 6 5.0 Cc1nnc2n1-c1sc(C#Cc3ccc4c(c3)CCO4)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL34796 126545 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 456 1 0 6 5.0 Cc1nnc2n1-c1sc(C#Cc3ccc4c(c3)CCO4)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
23214297 60283 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 566 12 2 8 6.5 CCCOc1c(NC(=O)N(O)Cc2ccccc2)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
CHEMBL160148 60283 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 566 12 2 8 6.5 CCCOc1c(NC(=O)N(O)Cc2ccccc2)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
10723353 86280 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 694 15 2 9 8.8 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCSc1ccc(Cl)c(Cl)c1 10.1021/jm980046r
CHEMBL2113724 86280 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 694 15 2 9 8.8 CCCCN(O)C(=O)Nc1cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCSc1ccc(Cl)c(Cl)c1 10.1021/jm980046r
14851868 79536 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 489 3 0 6 4.1 Cc1nnc2n1-c1ccc(C#CCCN3C(=O)c4ccccc4C3=O)cc1C(c1ccccc1F)=NC2 10.1021/jm00107a048
CHEMBL19991 79536 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 489 3 0 6 4.1 Cc1nnc2n1-c1ccc(C#CCCN3C(=O)c4ccccc4C3=O)cc1C(c1ccccc1F)=NC2 10.1021/jm00107a048
13557486 107830 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 415 7 1 6 3.5 CC(C)c1ccc2nc3ccc(C(=O)NCCCCc4cncnc4)cn3c(=O)c2c1 10.1021/jm00397a034
CHEMBL294706 107830 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 415 7 1 6 3.5 CC(C)c1ccc2nc3ccc(C(=O)NCCCCc4cncnc4)cn3c(=O)c2c1 10.1021/jm00397a034
14850517 106536 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 453 3 0 7 3.5 Cc1nnc2n1-c1sc(/C=C/C(=O)N3CCOCC3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL285067 106536 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 453 3 0 7 3.5 Cc1nnc2n1-c1sc(/C=C/C(=O)N3CCOCC3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
14547222 201766 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 356 8 1 2 4.7 O=C(C=C(c1ccccc1)c1ccccc1)NCCCCc1cccnc1 10.1021/jm00128a026
CHEMBL54709 201766 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 356 8 1 2 4.7 O=C(C=C(c1ccccc1)c1ccccc1)NCCCCc1cccnc1 10.1021/jm00128a026
101749 169991 37 None - 0 Guinea pig 5.4 pIC50 = 5.4 Binding
Inhibition of PAF receptor binding to rabbit platelet plasma membranesInhibition of PAF receptor binding to rabbit platelet plasma membranes
ChEMBL 372 6 0 5 4.8 COc1ccc([C@H]2O[C@@H](c3ccc(OC)c(OC)c3)[C@H](C)[C@@H]2C)cc1OC 10.1021/jm00160a020
CHEMBL418309 169991 37 None - 0 Guinea pig 5.4 pIC50 = 5.4 Binding
Inhibition of PAF receptor binding to rabbit platelet plasma membranesInhibition of PAF receptor binding to rabbit platelet plasma membranes
ChEMBL 372 6 0 5 4.8 COc1ccc([C@H]2O[C@@H](c3ccc(OC)c(OC)c3)[C@H](C)[C@@H]2C)cc1OC 10.1021/jm00160a020
11975378 204144 13 None - 0 Guinea pig 5.4 pIC50 = 5.4 Binding
Inhibition of PAF receptor binding to rabbit platelet plasma membranesInhibition of PAF receptor binding to rabbit platelet plasma membranes
ChEMBL 372 6 0 5 4.8 COc1ccc([C@H]2O[C@H](c3ccc(OC)c(OC)c3)[C@@H](C)[C@@H]2C)cc1OC 10.1021/jm00160a020
CHEMBL56917 204144 13 None - 0 Guinea pig 5.4 pIC50 = 5.4 Binding
Inhibition of PAF receptor binding to rabbit platelet plasma membranesInhibition of PAF receptor binding to rabbit platelet plasma membranes
ChEMBL 372 6 0 5 4.8 COc1ccc([C@H]2O[C@H](c3ccc(OC)c(OC)c3)[C@@H](C)[C@@H]2C)cc1OC 10.1021/jm00160a020
443018 205010 15 None - 0 Guinea pig 5.4 pIC50 = 5.4 Binding
Inhibition of PAF receptor binding to rabbit platelet plasma membranesInhibition of PAF receptor binding to rabbit platelet plasma membranes
ChEMBL 372 6 0 5 4.8 COc1ccc([C@@H]2O[C@@H](c3ccc(OC)c(OC)c3)[C@@H](C)[C@@H]2C)cc1OC 10.1021/jm00160a020
CHEMBL57542 205010 15 None - 0 Guinea pig 5.4 pIC50 = 5.4 Binding
Inhibition of PAF receptor binding to rabbit platelet plasma membranesInhibition of PAF receptor binding to rabbit platelet plasma membranes
ChEMBL 372 6 0 5 4.8 COc1ccc([C@@H]2O[C@@H](c3ccc(OC)c(OC)c3)[C@@H](C)[C@@H]2C)cc1OC 10.1021/jm00160a020
44372545 55531 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 532 10 2 8 6.1 CCCOc1c(NC(=O)N(O)C(C)(C)C)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
CHEMBL155851 55531 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 532 10 2 8 6.1 CCCOc1c(NC(=O)N(O)C(C)(C)C)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
10060534 110762 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 247 1 0 3 2.7 C1=C(c2ccncc2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
CHEMBL309310 110762 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 247 1 0 3 2.7 C1=C(c2ccncc2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
10594033 213365 0 None - 0 Guinea pig 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 350 4 0 4 4.4 COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CCC(C)[C@@H]2CCC1CCOC1=O 10.1021/jm970569j
CHEMBL88886 213365 0 None - 0 Guinea pig 5.3 pIC50 = 5.3 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 350 4 0 4 4.4 COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CCC(C)[C@@H]2CCC1CCOC1=O 10.1021/jm970569j
14347413 168784 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 462 16 1 3 7.3 CCCCCCCC/C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1021/jm00128a026
CHEMBL415953 168784 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 462 16 1 3 7.3 CCCCCCCC/C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1021/jm00128a026
44284549 106417 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 405 6 0 5 5.3 Cc1nc2cnccc2n1CCCOC1CCC(c2ccc(Cl)c(Cl)c2)O1 10.1016/S0960-894X(00)80006-2
CHEMBL284276 106417 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 405 6 0 5 5.3 Cc1nc2cnccc2n1CCCOC1CCC(c2ccc(Cl)c(Cl)c2)O1 10.1016/S0960-894X(00)80006-2
14570103 174633 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 428 9 1 4 4.9 C#Cc1cc(C(=O)N[C@H](C)CCCc2cccnc2)ccc1-c1ccc(OC)c(OC)c1 10.1021/jm00128a025
CHEMBL430969 174633 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 428 9 1 4 4.9 C#Cc1cc(C(=O)N[C@H](C)CCCc2cccnc2)ccc1-c1ccc(OC)c(OC)c1 10.1021/jm00128a025
14570090 201517 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 406 8 1 2 6.2 O=C(NCCCCc1cccnc1)c1ccc(-c2ccccc2)c(-c2ccccc2)c1 10.1021/jm00128a025
CHEMBL53584 201517 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 406 8 1 2 6.2 O=C(NCCCCc1cccnc1)c1ccc(-c2ccccc2)c(-c2ccccc2)c1 10.1021/jm00128a025
14851845 79410 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 477 2 0 6 3.8 Cc1nnc2n1-c1ccc(C#CCN3C(=O)COc4ccccc43)cc1C(c1ccccc1F)=NC2 10.1021/jm00107a048
CHEMBL19947 79410 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 477 2 0 6 3.8 Cc1nnc2n1-c1ccc(C#CCN3C(=O)COc4ccccc43)cc1C(c1ccccc1F)=NC2 10.1021/jm00107a048
14851908 80684 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 529 2 0 6 4.4 O=C1c2ccccc2C(=O)N1CC#Cc1ccc2c(c1)C(c1ccccc1F)=NCc1nnc(C(F)(F)F)n1-2 10.1021/jm00107a048
CHEMBL20194 80684 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 529 2 0 6 4.4 O=C1c2ccccc2C(=O)N1CC#Cc1ccc2c(c1)C(c1ccccc1F)=NCc1nnc(C(F)(F)F)n1-2 10.1021/jm00107a048
14851860 80708 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 519 2 0 6 5.8 Cc1nnc2n1-c1sc(C#CCN3C(=O)c4cccc5cccc3c45)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20208 80708 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 519 2 0 6 5.8 Cc1nnc2n1-c1sc(C#CCN3C(=O)c4cccc5cccc3c45)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14851884 84344 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 533 2 0 7 5.1 Cc1nnc2n1-c1sc(C#CCN3C(=O)COc4ccc(Cl)cc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20877 84344 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 533 2 0 7 5.1 Cc1nnc2n1-c1sc(C#CCN3C(=O)COc4ccc(Cl)cc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14851862 105396 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 468 2 0 7 5.0 Cc1nnc2n1-c1sc(C#CCn3cnc4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL277029 105396 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 468 2 0 7 5.0 Cc1nnc2n1-c1sc(C#CCn3cnc4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14851889 105868 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 497 2 0 6 4.7 Cc1nnc2n1-c1sc(C#CCN3CCc4ccccc4C3=O)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL280683 105868 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 497 2 0 6 4.7 Cc1nnc2n1-c1sc(C#CCN3CCc4ccccc4C3=O)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
1859 7223 62 None -2 2 Human 7.3 pIC50 = 7.3 Binding
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1016/S0960-894X(01)81205-1
1860 7223 62 None -2 2 Human 7.3 pIC50 = 7.3 Binding
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1016/S0960-894X(01)81205-1
65889 7223 62 None -2 2 Human 7.3 pIC50 = 7.3 Binding
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1016/S0960-894X(01)81205-1
CHEMBL280164 7223 62 None -2 2 Human 7.3 pIC50 = 7.3 Binding
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1016/S0960-894X(01)81205-1
14964722 115239 1 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 444 7 0 6 5.0 COc1cc(CCc2ccc(C3=Cc4oc(C)cc4C4=NCCN34)cc2)cc(OC)c1OC 10.1021/jm00073a008
CHEMBL319921 115239 1 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 444 7 0 6 5.0 COc1cc(CCc2ccc(C3=Cc4oc(C)cc4C4=NCCN34)cc2)cc(OC)c1OC 10.1021/jm00073a008
10715262 126383 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 387 3 0 5 5.0 C/C1=C\CC[C@@]2(C)O[C@@H]2C(=O)[C@@H]2CC[C@@H](C)[C@](C)(CC1)[C@H]2COc1ccon1 10.1021/jm950640q
CHEMBL346391 126383 0 None - 0 Guinea pig 7.3 pIC50 = 7.3 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 387 3 0 5 5.0 C/C1=C\CC[C@@]2(C)O[C@@H]2C(=O)[C@@H]2CC[C@@H](C)[C@](C)(CC1)[C@H]2COc1ccon1 10.1021/jm950640q
14547302 197708 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 392 11 1 3 5.4 CCC/C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1021/jm00128a026
CHEMBL51855 197708 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 392 11 1 3 5.4 CCC/C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1021/jm00128a026
14347360 201481 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 516 13 1 6 5.6 COc1ccc(C(=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)c2ccc(OC)c(OC)c2)cc1OC 10.1021/jm00128a026
CHEMBL53372 201481 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 516 13 1 6 5.6 COc1ccc(C(=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)c2ccc(OC)c(OC)c2)cc1OC 10.1021/jm00128a026
14570092 108526 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 420 8 1 2 6.6 C[C@H](CCCc1cccnc1)NC(=O)c1ccc(-c2ccccc2)c(-c2ccccc2)c1 10.1021/jm00128a025
CHEMBL299760 108526 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 420 8 1 2 6.6 C[C@H](CCCc1cccnc1)NC(=O)c1ccc(-c2ccccc2)c(-c2ccccc2)c1 10.1021/jm00128a025
14570109 174826 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 446 11 1 4 5.9 CCCc1cc(C(=O)N[C@H](C)CCCc2cccnc2)ccc1-c1ccc(OC)c(OC)c1 10.1021/jm00128a025
CHEMBL432324 174826 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 446 11 1 4 5.9 CCCc1cc(C(=O)N[C@H](C)CCCc2cccnc2)ccc1-c1ccc(OC)c(OC)c1 10.1021/jm00128a025
14851921 105646 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 491 2 1 6 3.9 Cc1nnc2n1-c1ccc(C#CCN3C(=O)CCc4ccccc43)cc1C(c1ccccc1F)=NC2O 10.1021/jm00107a048
CHEMBL279021 105646 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 491 2 1 6 3.9 Cc1nnc2n1-c1ccc(C#CCN3C(=O)CCc4ccccc43)cc1C(c1ccccc1F)=NC2O 10.1021/jm00107a048
13557472 108609 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 386 6 1 5 3.3 Cc1ccc2nc3ccc(C(=O)NCCCCc4cccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
CHEMBL300338 108609 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 386 6 1 5 3.3 Cc1ccc2nc3ccc(C(=O)NCCCCc4cccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
44370606 126329 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
ChEMBL 361 4 0 3 4.8 Cc1nc2ccccc2n1Cc1ccc(C(=O)N(C)C2CCCCC2)cc1 10.1016/S0960-894X(01)81205-1
CHEMBL345902 126329 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.
ChEMBL 361 4 0 3 4.8 Cc1nc2ccccc2n1Cc1ccc(C(=O)N(C)C2CCCCC2)cc1 10.1016/S0960-894X(01)81205-1
14964719 11691 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 482 7 0 5 6.1 COc1cc(CCc2ccc(C3=Cc4ccccc4C4=NCC(C)(C)CN34)cc2)cc(OC)c1OC 10.1021/jm00073a008
CHEMBL104631 11691 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 482 7 0 5 6.1 COc1cc(CCc2ccc(C3=Cc4ccccc4C4=NCC(C)(C)CN34)cc2)cc(OC)c1OC 10.1021/jm00073a008
13491509 107363 3 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Inhibition of PAF receptor binding to rabbit platelet plasma membranesInhibition of PAF receptor binding to rabbit platelet plasma membranes
ChEMBL 344 6 0 5 4.3 COc1ccc([C@H]2CC[C@H](c3ccc(OC)c(OC)c3)O2)cc1OC 10.1021/jm00160a020
CHEMBL291668 107363 3 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Inhibition of PAF receptor binding to rabbit platelet plasma membranesInhibition of PAF receptor binding to rabbit platelet plasma membranes
ChEMBL 344 6 0 5 4.3 COc1ccc([C@H]2CC[C@H](c3ccc(OC)c(OC)c3)O2)cc1OC 10.1021/jm00160a020
44284425 126410 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 397 8 0 7 3.7 COc1ccc(C2CCC(COCCn3c(C)nc4cnccc43)O2)cc1OC 10.1016/S0960-894X(00)80006-2
CHEMBL34669 126410 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 397 8 0 7 3.7 COc1ccc(C2CCC(COCCn3c(C)nc4cnccc43)O2)cc1OC 10.1016/S0960-894X(00)80006-2
44284228 145436 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 411 9 0 7 4.4 COc1ccc(C2CCC(OCCCCn3c(C)nc4cnccc43)O2)cc1OC 10.1016/S0960-894X(00)80006-2
CHEMBL37770 145436 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 411 9 0 7 4.4 COc1ccc(C2CCC(OCCCCn3c(C)nc4cnccc43)O2)cc1OC 10.1016/S0960-894X(00)80006-2
14570078 201677 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 344 7 1 2 4.8 Cc1cccc(-c2ccc(C(=O)NCCCCc3cccnc3)cc2)c1 10.1021/jm00128a025
CHEMBL54095 201677 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 344 7 1 2 4.8 Cc1cccc(-c2ccc(C(=O)NCCCCc3cccnc3)cc2)c1 10.1021/jm00128a025
44280378 106276 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Inhibitor concentration required to block 50 of the specific [3H]PAF binding to rabbit platelet membranes.Inhibitor concentration required to block 50 of the specific [3H]PAF binding to rabbit platelet membranes.
ChEMBL 370 7 0 5 4.2 C=CCC1=CC2(OCC)C(=CC1=O)O[C@H](c1ccc(OC)c(OC)c1)[C@H]2C 10.1021/jm00384a023
CHEMBL283282 106276 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Inhibitor concentration required to block 50 of the specific [3H]PAF binding to rabbit platelet membranes.Inhibitor concentration required to block 50 of the specific [3H]PAF binding to rabbit platelet membranes.
ChEMBL 370 7 0 5 4.2 C=CCC1=CC2(OCC)C(=CC1=O)O[C@H](c1ccc(OC)c(OC)c1)[C@H]2C 10.1021/jm00384a023
14894759 106167 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 478 2 0 6 4.0 Cc1nnc2n1-c1ccc(C#CCN3C(=O)c4ccccc4C3=O)cc1C(c1ccccc1F)OC2 10.1021/jm00107a048
CHEMBL282666 106167 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 478 2 0 6 4.0 Cc1nnc2n1-c1ccc(C#CCN3C(=O)c4ccccc4C3=O)cc1C(c1ccccc1F)OC2 10.1021/jm00107a048
13557479 203850 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 414 7 1 5 4.1 CC(C)c1ccc2nc3ccc(C(=O)NCCCCc4ccccn4)cn3c(=O)c2c1 10.1021/jm00397a034
CHEMBL56742 203850 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 414 7 1 5 4.1 CC(C)c1ccc2nc3ccc(C(=O)NCCCCc4ccccn4)cn3c(=O)c2c1 10.1021/jm00397a034
44283768 107101 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 317 6 0 3 4.6 Clc1ccc([C@@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1 10.1016/S0960-894X(00)80005-0
CHEMBL289406 107101 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 317 6 0 3 4.6 Clc1ccc([C@@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1 10.1016/S0960-894X(00)80005-0
14851879 106352 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 573 2 0 8 5.5 Cc1nnc2n1-c1sc(C#CCn3c(=O)c4ccccc4c4ccccc4c3=O)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL283790 106352 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 573 2 0 8 5.5 Cc1nnc2n1-c1sc(C#CCn3c(=O)c4ccccc4c4ccccc4c3=O)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
44372409 60919 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 490 10 2 8 5.0 CCCOc1c(NC(=O)N(C)O)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
CHEMBL160692 60919 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 490 10 2 8 5.0 CCCOc1c(NC(=O)N(C)O)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
10015480 112515 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 260 1 0 2 3.6 Cc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
CHEMBL312650 112515 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 260 1 0 2 3.6 Cc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
10378955 211957 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 280 1 0 2 3.9 Clc1cccc(C2=Cc3ccccc3C3=NCCN23)c1 10.1021/jm00002a004
CHEMBL78310 211957 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 280 1 0 2 3.9 Clc1cccc(C2=Cc3ccccc3C3=NCCN23)c1 10.1021/jm00002a004
44329225 114894 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 480 10 1 4 6.5 COc1ccc(-c2c(/C=C/C(=O)N[C@@H](C)CCCc3cccnc3)ccc3cc(OC)ccc23)cc1 10.1021/jm00172a029
CHEMBL319568 114894 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 480 10 1 4 6.5 COc1ccc(-c2c(/C=C/C(=O)N[C@@H](C)CCCc3cccnc3)ccc3cc(OC)ccc23)cc1 10.1021/jm00172a029
14347339 108596 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 502 13 1 6 5.2 COc1ccc(C(=C/C=C/C(=O)NCCCCc2cccnc2)c2ccc(OC)c(OC)c2)cc1OC 10.1021/jm00128a026
CHEMBL300251 108596 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 502 13 1 6 5.2 COc1ccc(C(=C/C=C/C(=O)NCCCCc2cccnc2)c2ccc(OC)c(OC)c2)cc1OC 10.1021/jm00128a026
44297137 199925 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 396 10 1 2 5.6 O=C(C/C=C/C=C(c1ccccc1)c1ccccc1)NCCCCc1cccnc1 10.1021/jm00128a026
CHEMBL52297 199925 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 396 10 1 2 5.6 O=C(C/C=C/C=C(c1ccccc1)c1ccccc1)NCCCCc1cccnc1 10.1021/jm00128a026
10765571 171640 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 440 3 0 5 6.1 C/C1=C\CC[C@@]2(C)O[C@@H]2C(=O)[C@@H]2CC[C@@H](C)[C@](C)(CC1)[C@H]2COC(=O)Oc1ccccc1 10.1021/jm950640q
CHEMBL421954 171640 0 None - 0 Guinea pig 6.3 pIC50 = 6.3 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 440 3 0 5 6.1 C/C1=C\CC[C@@]2(C)O[C@@H]2C(=O)[C@@H]2CC[C@@H](C)[C@](C)(CC1)[C@H]2COC(=O)Oc1ccccc1 10.1021/jm950640q
15097565 200376 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 412 12 1 2 6.2 O=C(CCCCC=C(c1ccccc1)c1ccccc1)NCCCCc1cccnc1 10.1021/jm00128a026
CHEMBL52693 200376 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 412 12 1 2 6.2 O=C(CCCCC=C(c1ccccc1)c1ccccc1)NCCCCc1cccnc1 10.1021/jm00128a026
9993602 110636 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 276 2 0 3 3.3 COc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
CHEMBL309194 110636 0 None - 0 Human 4.3 pIC50 = 4.3 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 276 2 0 3 3.3 COc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
44372461 55430 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 574 15 1 8 6.9 CCCOc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(N(CC)C(=O)N(O)CCC)c1OCCC 10.1016/0960-894X(95)00088-B
CHEMBL155760 55430 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 574 15 1 8 6.9 CCCOc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(N(CC)C(=O)N(O)CCC)c1OCCC 10.1016/0960-894X(95)00088-B
44273370 105708 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 561 2 1 7 5.6 Cc1nnc2n1-c1sc(C#CCn3c(=O)c4ccccc4c4ccccc43)cc1C(c1ccccc1Cl)NC2=O 10.1021/jm00107a048
CHEMBL279476 105708 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 561 2 1 7 5.6 Cc1nnc2n1-c1sc(C#CCn3c(=O)c4ccccc4c4ccccc43)cc1C(c1ccccc1Cl)NC2=O 10.1021/jm00107a048
10015659 111154 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 264 1 0 2 3.4 Fc1ccccc1C1=Cc2ccccc2C2=NCCN12 10.1021/jm00002a004
CHEMBL310238 111154 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 264 1 0 2 3.4 Fc1ccccc1C1=Cc2ccccc2C2=NCCN12 10.1021/jm00002a004
21577212 75028 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor in human plateletInhibition of [3H]PAF binding to platelet activating factor receptor in human platelet
ChEMBL 318 0 1 3 4.1 C/C1=C\CC[C@]2(C)O[C@H]2[C@@]2(O)OCC3=C2CC[C@@H](C)[C@]3(C)CC1 10.1016/j.bmcl.2005.04.048
CHEMBL191612 75028 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor in human plateletInhibition of [3H]PAF binding to platelet activating factor receptor in human platelet
ChEMBL 318 0 1 3 4.1 C/C1=C\CC[C@]2(C)O[C@H]2[C@@]2(O)OCC3=C2CC[C@@H](C)[C@]3(C)CC1 10.1016/j.bmcl.2005.04.048
11771535 140665 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor in human plateletInhibition of [3H]PAF binding to platelet activating factor receptor in human platelet
ChEMBL 318 0 1 3 4.1 C/C1=C\CC[C@@]2(C)O[C@@H]2[C@@]2(O)OCC3=C2CC[C@@H](C)[C@]3(C)CC1 10.1016/j.bmcl.2005.04.048
CHEMBL371569 140665 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor in human plateletInhibition of [3H]PAF binding to platelet activating factor receptor in human platelet
ChEMBL 318 0 1 3 4.1 C/C1=C\CC[C@@]2(C)O[C@@H]2[C@@]2(O)OCC3=C2CC[C@@H](C)[C@]3(C)CC1 10.1016/j.bmcl.2005.04.048
44372459 55560 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 518 11 2 8 5.7 CCCOc1c(NC(=O)N(O)C(C)C)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
CHEMBL155873 55560 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 518 11 2 8 5.7 CCCOc1c(NC(=O)N(O)C(C)C)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
71716651 92774 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Compound was evaluated for anti-platelet activating factor potencyCompound was evaluated for anti-platelet activating factor potency
ChEMBL 544 5 2 11 0.8 C[C@@H]1C(=O)O[C@H]2[C@H](OCOCc3ccccc3)C34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6O)O[C@@]4(C(=O)O5)[C@@]12O 10.1016/s0960-894x(98)00205-4
CHEMBL2304166 92774 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Compound was evaluated for anti-platelet activating factor potencyCompound was evaluated for anti-platelet activating factor potency
ChEMBL 544 5 2 11 0.8 C[C@@H]1C(=O)O[C@H]2[C@H](OCOCc3ccccc3)C34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6O)O[C@@]4(C(=O)O5)[C@@]12O 10.1016/s0960-894x(98)00205-4
23214297 60283 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 566 12 2 8 6.5 CCCOc1c(NC(=O)N(O)Cc2ccccc2)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
CHEMBL160148 60283 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 566 12 2 8 6.5 CCCOc1c(NC(=O)N(O)Cc2ccccc2)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
44372678 61099 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 532 13 2 8 5.8 CCCOc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(N(O)C(=O)NCC)c1OCCC 10.1016/0960-894X(95)00088-B
CHEMBL160839 61099 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 532 13 2 8 5.8 CCCOc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(N(O)C(=O)NCC)c1OCCC 10.1016/0960-894X(95)00088-B
10042229 211998 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 329 3 0 3 3.9 C1=C(c2ccc(CN3CCCC3)cc2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
CHEMBL78642 211998 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 329 3 0 3 3.9 C1=C(c2ccc(CN3CCCC3)cc2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
131925 108549 17 None 2 2 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 510 12 1 9 3.9 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO 10.1021/jm980046r
CHEMBL299944 108549 17 None 2 2 Human 8.2 pIC50 = 8.2 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 510 12 1 9 3.9 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO 10.1021/jm980046r
44328916 114116 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 430 11 1 3 6.1 CCCCc1c(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)ccc2c(OC)cccc12 10.1021/jm00172a029
CHEMBL317579 114116 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 430 11 1 3 6.1 CCCCc1c(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)ccc2c(OC)cccc12 10.1021/jm00172a029
14851883 86636 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 573 2 0 8 5.5 Cc1nnc2n1-c1sc(C#CCn3c(=O)c4ccccc4c(=O)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL21224 86636 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 573 2 0 8 5.5 Cc1nnc2n1-c1sc(C#CCn3c(=O)c4ccccc4c(=O)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14851911 105422 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 489 2 0 5 5.0 Cc1nnc2n1-c1ccc(C#CCN3C(=O)CCc4ccccc43)cc1C(c1ccccc1F)=N[C@H]2C 10.1021/jm00107a048
CHEMBL277246 105422 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 489 2 0 5 5.0 Cc1nnc2n1-c1ccc(C#CCN3C(=O)CCc4ccccc43)cc1C(c1ccccc1F)=N[C@H]2C 10.1021/jm00107a048
44273306 106210 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 522 3 0 8 5.1 C=C=Cn1c(=O)n(CC#Cc2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)c2ccccc21 10.1021/jm00107a048
CHEMBL282905 106210 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 522 3 0 8 5.1 C=C=Cn1c(=O)n(CC#Cc2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)c2ccccc21 10.1021/jm00107a048
44273305 175348 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 498 2 1 6 4.7 Cc1nnc2n1-c1sc(C#CCN3C(=O)NCc4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL435756 175348 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 498 2 1 6 4.7 Cc1nnc2n1-c1sc(C#CCN3C(=O)NCc4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
159547 10342 19 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 440 7 0 5 5.1 COc1cc(CCc2ccc(cc2)c2cc3ccccc3c3=NCCn23)cc(c1OC)OC 10.1021/jm00073a008
1855 10342 19 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 440 7 0 5 5.1 COc1cc(CCc2ccc(cc2)c2cc3ccccc3c3=NCCn23)cc(c1OC)OC 10.1021/jm00073a008
CHEMBL449395 10342 19 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 440 7 0 5 5.1 COc1cc(CCc2ccc(cc2)c2cc3ccccc3c3=NCCn23)cc(c1OC)OC 10.1021/jm00073a008
14964715 11722 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 468 7 0 5 5.9 COc1cc(CCc2ccc(C3=Cc4ccccc4C4=NC(C)(C)CN34)cc2)cc(OC)c1OC 10.1021/jm00073a008
CHEMBL104767 11722 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 468 7 0 5 5.9 COc1cc(CCc2ccc(C3=Cc4ccccc4C4=NC(C)(C)CN34)cc2)cc(OC)c1OC 10.1021/jm00073a008
15084152 106392 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 497 2 0 7 6.2 Cc1nnc2n1-c1sc(C#Cc3ccc(-c4ccccn4)s3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL284079 106392 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 497 2 0 7 6.2 Cc1nnc2n1-c1sc(C#Cc3ccc(-c4ccccn4)s3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
14347341 200210 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 450 9 1 2 6.5 O=C(/C=C/C=C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)NCCCCc1cccnc1 10.1021/jm00128a026
CHEMBL52615 200210 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 450 9 1 2 6.5 O=C(/C=C/C=C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)NCCCCc1cccnc1 10.1021/jm00128a026
44297376 201351 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 482 12 1 4 6.0 COc1ccc(C(=C/C=C/C(=O)N[C@@H](CCCc2cccnc2)C2CC2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
CHEMBL53029 201351 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 482 12 1 4 6.0 COc1ccc(C(=C/C=C/C(=O)N[C@@H](CCCc2cccnc2)C2CC2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
14347370 202099 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 410 9 1 2 5.8 Cc1ccc(C(=C/C=C/C(=O)NCCCCc2cccnc2)c2ccc(C)cc2)cc1 10.1021/jm00128a026
CHEMBL55156 202099 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 410 9 1 2 5.8 Cc1ccc(C(=C/C=C/C(=O)NCCCCc2cccnc2)c2ccc(C)cc2)cc1 10.1021/jm00128a026
14570115 201655 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 420 9 1 4 5.9 COc1ccc(-c2ccc(C(S)=N[C@H](C)CCCc3cccnc3)cc2)cc1OC 10.1021/jm00128a025
CHEMBL54041 201655 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 420 9 1 4 5.9 COc1ccc(-c2ccc(C(S)=N[C@H](C)CCCc3cccnc3)cc2)cc1OC 10.1021/jm00128a025
107681 8004 29 None - 1 Human 6.2 pIC50 = 6.2 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 592 27 1 8 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)(OCC[n+]1ccsc1)[O-])OC 10.1021/jm00397a034
6079 8004 29 None - 1 Human 6.2 pIC50 = 6.2 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 592 27 1 8 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)(OCC[n+]1ccsc1)[O-])OC 10.1021/jm00397a034
CHEMBL295212 8004 29 None - 1 Human 6.2 pIC50 = 6.2 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 592 27 1 8 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)(OCC[n+]1ccsc1)[O-])OC 10.1021/jm00397a034
13557506 40756 1 None - 0 Human 6.2 pIC50 = 6.2 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 428 7 1 5 4.5 CC(C)c1ccc2nc3ccc(C(=O)N[C@H](C)CCCc4cccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
CHEMBL142433 40756 1 None - 0 Human 6.2 pIC50 = 6.2 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 428 7 1 5 4.5 CC(C)c1ccc2nc3ccc(C(=O)N[C@H](C)CCCc4cccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
13557474 205205 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 430 8 1 6 3.8 CC(C)Oc1ccc2nc3ccc(C(=O)NCCCCc4cccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
CHEMBL57716 205205 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 430 8 1 6 3.8 CC(C)Oc1ccc2nc3ccc(C(=O)NCCCCc4cccnc4)cn3c(=O)c2c1 10.1021/jm00397a034
44283890 126967 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 283 6 0 3 3.9 c1ccc(C2CCC(OCCCc3cccnc3)O2)cc1 10.1016/S0960-894X(00)80005-0
CHEMBL35181 126967 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 283 6 0 3 3.9 c1ccc(C2CCC(OCCCc3cccnc3)O2)cc1 10.1016/S0960-894X(00)80005-0
44283867 144931 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 357 9 0 5 4.3 COc1ccc(C2CCC(OCCCCc3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
CHEMBL37686 144931 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 357 9 0 5 4.3 COc1ccc(C2CCC(OCCCCc3cccnc3)O2)cc1OC 10.1016/S0960-894X(00)80005-0
10736370 119591 0 None - 0 Guinea pig 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 346 4 0 4 4.2 C=C1CCC2[C@@](C)(C(=O)OC)CCC[C@]2(C)[C@H]1CCC1=CC(=O)OC1 10.1021/jm970569j
CHEMBL330708 119591 0 None - 0 Guinea pig 5.2 pIC50 = 5.2 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 346 4 0 4 4.2 C=C1CCC2[C@@](C)(C(=O)OC)CCC[C@]2(C)[C@H]1CCC1=CC(=O)OC1 10.1021/jm970569j
14570074 168882 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 330 7 1 2 4.5 O=C(NCCCCc1cccnc1)c1ccc(-c2ccccc2)cc1 10.1021/jm00128a025
CHEMBL416120 168882 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 330 7 1 2 4.5 O=C(NCCCCc1cccnc1)c1ccc(-c2ccccc2)cc1 10.1021/jm00128a025
10423490 170173 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Compound were tested for the inhibition of [3H]PAF binding to human platelets.Compound were tested for the inhibition of [3H]PAF binding to human platelets.
ChEMBL 274 2 0 2 3.8 CCc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
CHEMBL419471 170173 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Compound were tested for the inhibition of [3H]PAF binding to human platelets.Compound were tested for the inhibition of [3H]PAF binding to human platelets.
ChEMBL 274 2 0 2 3.8 CCc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
14347357 200183 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 456 11 1 4 5.6 COc1ccc(C(=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
CHEMBL52577 200183 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 456 11 1 4 5.6 COc1ccc(C(=C/C=C/C(=O)N[C@H](C)CCCc2cccnc2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
15084140 118254 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 470 4 0 5 6.4 CCCCc1ccc(C#Cc2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)cc1 10.1021/jm00108a031
CHEMBL32767 118254 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 470 4 0 5 6.4 CCCCc1ccc(C#Cc2cc3c(s2)-n2c(C)nnc2CN=C3c2ccccc2Cl)cc1 10.1021/jm00108a031
9973198 211984 1 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 318 2 0 2 3.8 C[Si](C)(C)c1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
CHEMBL78545 211984 1 None - 0 Human 5.2 pIC50 = 5.2 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 318 2 0 2 3.8 C[Si](C)(C)c1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
44372644 175083 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 546 13 1 8 6.2 CCCOc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(N(CC)C(=O)N(C)O)c1OCCC 10.1016/0960-894X(95)00088-B
CHEMBL434090 175083 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 546 13 1 8 6.2 CCCOc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(N(CC)C(=O)N(C)O)c1OCCC 10.1016/0960-894X(95)00088-B
44328858 214825 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 430 11 1 3 6.1 CCCCc1c(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)ccc2cc(OC)ccc12 10.1021/jm00172a029
CHEMBL97530 214825 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 430 11 1 3 6.1 CCCCc1c(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)ccc2cc(OC)ccc12 10.1021/jm00172a029
44284581 106980 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 397 8 0 7 4.0 COc1ccc([C@H]2CC[C@@H](OCCCn3c(C)nc4cnccc43)O2)cc1OC 10.1016/S0960-894X(00)80006-2
CHEMBL288329 106980 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 397 8 0 7 4.0 COc1ccc([C@H]2CC[C@@H](OCCCn3c(C)nc4cnccc43)O2)cc1OC 10.1016/S0960-894X(00)80006-2
44284551 143237 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 355 6 0 5 4.2 Cc1nc2cnccc2n1CCCOC1CCC(c2ccc(F)cc2)O1 10.1016/S0960-894X(00)80006-2
CHEMBL37358 143237 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 355 6 0 5 4.2 Cc1nc2cnccc2n1CCCOC1CCC(c2ccc(F)cc2)O1 10.1016/S0960-894X(00)80006-2
14851859 79563 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 497 2 0 7 4.2 Cc1nnc2n1-c1sc(C#CCN3C(=O)C(=O)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20003 79563 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 497 2 0 7 4.2 Cc1nnc2n1-c1sc(C#CCN3C(=O)C(=O)c4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
44273471 81730 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 531 2 0 6 5.6 Cc1nnc2n1-c1sc(C#CCN3C(=O)CCc4ccc(Cl)cc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20323 81730 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 531 2 0 6 5.6 Cc1nnc2n1-c1sc(C#CCN3C(=O)CCc4ccc(Cl)cc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
14851844 105472 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 493 2 0 6 4.6 Cc1nnc2n1-c1ccc(C#CCN3C(=O)CSc4ccccc43)cc1C(c1ccccc1F)=NC2 10.1021/jm00107a048
CHEMBL277618 105472 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 493 2 0 6 4.6 Cc1nnc2n1-c1ccc(C#CCN3C(=O)CSc4ccccc43)cc1C(c1ccccc1F)=NC2 10.1021/jm00107a048
14851891 105529 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 521 2 0 6 6.5 Cc1nnc2n1-c1sc(C#CCn3c4c(c5ccccc53)CCCC4)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL278072 105529 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 521 2 0 6 6.5 Cc1nnc2n1-c1sc(C#CCn3c4c(c5ccccc53)CCCC4)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
443058 86455 4 None - 0 Guinea pig 7.2 pIC50 = 7.2 Binding
Inhibitor concentration required to block 50 of the specific [3H]PAF binding to rabbit platelet membranes.Inhibitor concentration required to block 50 of the specific [3H]PAF binding to rabbit platelet membranes.
ChEMBL 358 6 0 5 4.0 CCCC1=C[C@@]2(OC)C(=CC1=O)O[C@H](c1ccc(OC)c(OC)c1)[C@H]2C 10.1021/jm00384a023
CHEMBL2115332 86455 4 None - 0 Guinea pig 7.2 pIC50 = 7.2 Binding
Inhibitor concentration required to block 50 of the specific [3H]PAF binding to rabbit platelet membranes.Inhibitor concentration required to block 50 of the specific [3H]PAF binding to rabbit platelet membranes.
ChEMBL 358 6 0 5 4.0 CCCC1=C[C@@]2(OC)C(=CC1=O)O[C@H](c1ccc(OC)c(OC)c1)[C@H]2C 10.1021/jm00384a023
44273765 84577 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 569 2 0 6 7.6 Cc1nnc2n1-c1sc(C#CCn3c4c(c5cc(Cl)ccc53)CCCCC4)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20927 84577 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 569 2 0 6 7.6 Cc1nnc2n1-c1sc(C#CCn3c4c(c5cc(Cl)ccc53)CCCCC4)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
13557476 205755 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 450 6 1 5 3.8 O=C(NCCCCc1cccnc1)c1ccc2nc3ccc(Br)cc3c(=O)n2c1 10.1021/jm00397a034
CHEMBL58518 205755 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Ability to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligandAbility to inhibit platelet activating factor (PAF) binding to platelets by 50% was determined by using [3H]PAF as radioligand
ChEMBL 450 6 1 5 3.8 O=C(NCCCCc1cccnc1)c1ccc2nc3ccc(Br)cc3c(=O)n2c1 10.1021/jm00397a034
14547299 200158 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 470 11 1 4 5.9 COc1ccc(C(=C/C=C/C(=O)NC(C)CCCc2ccc(C)nc2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
CHEMBL52526 200158 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 470 11 1 4 5.9 COc1ccc(C(=C/C=C/C(=O)NC(C)CCCc2ccc(C)nc2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
44296798 195087 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of platelet-activating factor receptor binding activity in dog platelets using [3H]-PAF as radioligand.Inhibition of platelet-activating factor receptor binding activity in dog platelets using [3H]-PAF as radioligand.
ChEMBL 436 9 1 3 6.3 O=C(NCCCCc1cccnc1)c1ccc(-c2cccc(OC3=CC=CC=CC3)c2)cc1 10.1021/jm00128a025
CHEMBL50050 195087 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of platelet-activating factor receptor binding activity in dog platelets using [3H]-PAF as radioligand.Inhibition of platelet-activating factor receptor binding activity in dog platelets using [3H]-PAF as radioligand.
ChEMBL 436 9 1 3 6.3 O=C(NCCCCc1cccnc1)c1ccc(-c2cccc(OC3=CC=CC=CC3)c2)cc1 10.1021/jm00128a025
135503537 212404 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 262 1 1 3 3.0 Oc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
CHEMBL81715 212404 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 262 1 1 3 3.0 Oc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
44273122 79325 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 561 3 1 8 5.3 O=c1c2ccccc2c2ccccc2n1CC#Cc1cc2c(s1)-n1c(CO)nnc1CN=C2c1ccccc1Cl 10.1021/jm00107a048
CHEMBL19917 79325 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 561 3 1 8 5.3 O=c1c2ccccc2c2ccccc2n1CC#Cc1cc2c(s1)-n1c(CO)nnc1CN=C2c1ccccc1Cl 10.1021/jm00107a048
44273268 84879 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 542 3 0 8 4.9 Cc1nnc2n1-c1sc(C#CCN3C(=O)CCc4ccccc43)cc1C(c1cc([N+](=O)[O-])ccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL21026 84879 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 542 3 0 8 4.9 Cc1nnc2n1-c1sc(C#CCN3C(=O)CCc4ccccc43)cc1C(c1cc([N+](=O)[O-])ccc1Cl)=NC2 10.1021/jm00107a048
9801987 112384 4 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 343 3 0 3 4.2 C1=C(c2ccc(CN3CCCCC3)cc2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
CHEMBL312225 112384 4 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 343 3 0 3 4.2 C1=C(c2ccc(CN3CCCCC3)cc2)N2CCN=C2c2ccccc21 10.1021/jm00002a004
23214230 126482 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 504 11 2 8 5.3 CCCOc1c(NC(=O)N(O)CC)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
CHEMBL347382 126482 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 504 11 2 8 5.3 CCCOc1c(NC(=O)N(O)CC)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
15084158 126175 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 501 5 0 7 6.6 Cc1nnc2n1-c1sc(CCc3ccc(-c4ccccn4)s3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL34461 126175 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 501 5 0 7 6.6 Cc1nnc2n1-c1sc(CCc3ccc(-c4ccccn4)s3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
44281321 106705 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 472 5 0 5 7.0 Cc1nnc2n1-c1sc(/C=C\c3ccc(CC(C)C)cc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
CHEMBL286229 106705 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
ChEMBL 472 5 0 5 7.0 Cc1nnc2n1-c1sc(/C=C\c3ccc(CC(C)C)cc3)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00108a031
10546751 51012 0 None - 0 Guinea pig 7.1 pIC50 = 7.1 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 364 2 1 4 4.3 CC(=O)OC[C@H]1[C@H]2CC[C@@H](C)[C@]1(C)CC/C(C)=C/CC[C@@]1(C)O[C@@H]1[C@@H]2O 10.1021/jm950640q
CHEMBL151688 51012 0 None - 0 Guinea pig 7.1 pIC50 = 7.1 Binding
Inhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAFInhibiting Platelet activating factor receptor by radioreceptor binding assay using rabbit platelets and [3H]-PAF
ChEMBL 364 2 1 4 4.3 CC(=O)OC[C@H]1[C@H]2CC[C@@H](C)[C@]1(C)CC/C(C)=C/CC[C@@]1(C)O[C@@H]1[C@@H]2O 10.1021/jm950640q
14570107 108027 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 444 11 1 4 5.6 C=CCc1cc(C(=O)N[C@H](C)CCCc2cccnc2)ccc1-c1ccc(OC)c(OC)c1 10.1021/jm00128a025
CHEMBL296169 108027 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand.
ChEMBL 444 11 1 4 5.6 C=CCc1cc(C(=O)N[C@H](C)CCCc2cccnc2)ccc1-c1ccc(OC)c(OC)c1 10.1021/jm00128a025
44273146 106029 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 513 2 0 7 4.3 Cc1nnc2n1-c1sc(C#CCN3C(=O)CCc4ccccc43)cc1C(C1=CC(=O)CC=C1Cl)=NC2 10.1021/jm00107a048
CHEMBL281780 106029 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 513 2 0 7 4.3 Cc1nnc2n1-c1sc(C#CCN3C(=O)CCc4ccccc43)cc1C(C1=CC(=O)CC=C1Cl)=NC2 10.1021/jm00107a048
44283767 144352 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 361 6 0 3 4.7 Brc1ccc([C@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1 10.1016/S0960-894X(00)80005-0
CHEMBL37547 144352 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesIn vitro inhibition of [3H]PAF receptor binding to washed human platelet membranes
ChEMBL 361 6 0 3 4.7 Brc1ccc([C@H]2CC[C@@H](OCCCc3cccnc3)O2)cc1 10.1016/S0960-894X(00)80005-0
44297357 108242 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 484 12 1 4 6.3 COc1ccc(C(=C/C=C/C(=O)N[C@@H](CCCc2cccnc2)C(C)C)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
CHEMBL297734 108242 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 484 12 1 4 6.3 COc1ccc(C(=C/C=C/C(=O)N[C@@H](CCCc2cccnc2)C(C)C)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
44322343 213393 0 None - 0 Guinea pig 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 364 4 0 6 2.9 COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CCC(=O)O[C@@H]2CCC1=CC(=O)OC1 10.1021/jm970569j
CHEMBL89059 213393 0 None - 0 Guinea pig 5.1 pIC50 = 5.1 Binding
In vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit plateletsIn vitro inhibitory activity against PAF receptor using [3H]PAF as radioligand in rabbit platelets
ChEMBL 364 4 0 6 2.9 COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CCC(=O)O[C@@H]2CCC1=CC(=O)OC1 10.1021/jm970569j
10378954 212313 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 280 1 0 2 3.9 Clc1ccccc1C1=Cc2ccccc2C2=NCCN12 10.1021/jm00002a004
CHEMBL80963 212313 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 280 1 0 2 3.9 Clc1ccccc1C1=Cc2ccccc2C2=NCCN12 10.1021/jm00002a004
9995815 112391 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 314 1 0 2 4.6 Clc1ccc(C2=Cc3ccccc3C3=NCCN23)c(Cl)c1 10.1021/jm00002a004
CHEMBL312268 112391 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 314 1 0 2 4.6 Clc1ccc(C2=Cc3ccccc3C3=NCCN23)c(Cl)c1 10.1021/jm00002a004
1853 10324 38 None - 1 Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against platelet activating factor receptorInhibitory concentration against platelet activating factor receptor
ChEMBL 352 0 0 2 4.3 Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 10.1021/jm058225d
60680 10324 38 None - 1 Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against platelet activating factor receptorInhibitory concentration against platelet activating factor receptor
ChEMBL 352 0 0 2 4.3 Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 10.1021/jm058225d
CHEMBL10971 10324 38 None - 1 Human 6.1 pIC50 = 6.1 Binding
Inhibitory concentration against platelet activating factor receptorInhibitory concentration against platelet activating factor receptor
ChEMBL 352 0 0 2 4.3 Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=O)C)nccc1 10.1021/jm058225d
14347338 204975 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 470 11 1 4 6.0 COc1ccc(C(=C/C=C/C(=O)NC(C)(C)CCCc2cccnc2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
CHEMBL57510 204975 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligandInhibition of platelet activating factor receptor binding activity in dog platelets using [3H]PAF as radioligand
ChEMBL 470 11 1 4 6.0 COc1ccc(C(=C/C=C/C(=O)NC(C)(C)CCCc2cccnc2)c2ccc(OC)cc2)cc1 10.1021/jm00128a026
44372459 55560 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 518 11 2 8 5.7 CCCOc1c(NC(=O)N(O)C(C)C)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
CHEMBL155873 55560 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 518 11 2 8 5.7 CCCOc1c(NC(=O)N(O)C(C)C)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1OC 10.1016/0960-894X(95)00088-B
14964723 115393 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 438 7 0 5 6.0 COc1cc(CCc2ccc(-c3cc4ccccc4c4nccn34)cc2)cc(OC)c1OC 10.1021/jm00073a008
CHEMBL320577 115393 0 None - 0 Human 4.1 pIC50 = 4.1 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 438 7 0 5 6.0 COc1cc(CCc2ccc(-c3cc4ccccc4c4nccn34)cc2)cc(OC)c1OC 10.1021/jm00073a008
14347411 201510 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 434 14 1 3 6.5 CCCCCC/C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1021/jm00128a026
CHEMBL53527 201510 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of [3H]PAF binding to dog platelets.Inhibition of [3H]PAF binding to dog platelets.
ChEMBL 434 14 1 3 6.5 CCCCCC/C(=C\C=C\C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1 10.1021/jm00128a026
14851888 81801 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 565 2 0 6 6.3 Cc1nnc2n1-c1sc(C#CCN3C(=O)CCc4cc(Cl)cc(Cl)c43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20343 81801 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 565 2 0 6 6.3 Cc1nnc2n1-c1sc(C#CCN3C(=O)CCc4cc(Cl)cc(Cl)c43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
44273479 105673 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 484 2 1 8 4.7 Cc1nnc2n1-c1sc(C#CCn3c(O)nc4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL279234 105673 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 484 2 1 8 4.7 Cc1nnc2n1-c1sc(C#CCn3c(O)nc4ccccc43)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
44329219 118728 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 432 11 1 3 6.1 CCCCC1=C(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)CCc2cc(OC)ccc21 10.1021/jm00172a029
CHEMBL328833 118728 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Inhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog bloodInhibition of [3H]PAF binding to platelet activating factor receptor citrate-treated dog blood
ChEMBL 432 11 1 3 6.1 CCCCC1=C(/C=C/C(=O)N[C@@H](C)CCCc2cccnc2)CCc2cc(OC)ccc21 10.1021/jm00172a029
44273427 83570 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 555 2 0 6 7.2 Cc1nnc2n1-c1sc(C#CCn3c4c(c5cc(Cl)ccc53)CCCC4)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
CHEMBL20690 83570 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
PAF-antagonist activity determined in dog platelets by PAF-binding assayPAF-antagonist activity determined in dog platelets by PAF-binding assay
ChEMBL 555 2 0 6 7.2 Cc1nnc2n1-c1sc(C#CCn3c4c(c5cc(Cl)ccc53)CCCC4)cc1C(c1ccccc1Cl)=NC2 10.1021/jm00107a048
10065779 212059 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 302 1 0 2 4.6 CC(C)(C)c1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
CHEMBL79089 212059 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 302 1 0 2 4.6 CC(C)(C)c1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
44284155 144634 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 444 7 0 6 5.7 COc1ccc(C2CCC(OCc3ccc(-n4c(C)nc5ccccc54)cc3)O2)cc1OC 10.1016/S0960-894X(00)80006-2
CHEMBL37602 144634 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Inhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitroInhibition of [3H]PAF receptor binding to washed human platelet membranes determined in vitro
ChEMBL 444 7 0 6 5.7 COc1ccc(C2CCC(OCc3ccc(-n4c(C)nc5ccccc54)cc3)O2)cc1OC 10.1016/S0960-894X(00)80006-2
44372629 60760 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 546 14 2 8 6.2 CCCNC(=O)N(O)c1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OCCC)c1OCCC 10.1016/0960-894X(95)00088-B
CHEMBL160571 60760 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.In vitro affinity for human PAF receptor on platelet membranes using [3H]PAF displacement.
ChEMBL 546 14 2 8 6.2 CCCNC(=O)N(O)c1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OCCC)c1OCCC 10.1016/0960-894X(95)00088-B
10021121 212274 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 355 7 0 3 4.4 C=CCN(CC=C)Cc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
CHEMBL80647 212274 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Inhibition of [3H]PAF binding to human platelet activating factor receptorInhibition of [3H]PAF binding to human platelet activating factor receptor
ChEMBL 355 7 0 3 4.4 C=CCN(CC=C)Cc1ccc(C2=Cc3ccccc3C3=NCCN23)cc1 10.1021/jm00002a004
1859 7223 62 None -2 2 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm980046r
1860 7223 62 None -2 2 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm980046r
65889 7223 62 None -2 2 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm980046r
CHEMBL280164 7223 62 None -2 2 Human 7.0 pIC50 = 7.0 Binding
Displacement of [3H]PAF from PAF receptor of human platelet membranesDisplacement of [3H]PAF from PAF receptor of human platelet membranes
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm980046r
14964727 12024 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 453 7 0 6 5.7 COc1cc(CCc2ccc(-c3cc4ccccc4c4nnc(C)n34)cc2)cc(OC)c1OC 10.1021/jm00073a008
CHEMBL106358 12024 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
In vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human plateletsIn vitro PAF antagonistic activity by determining [3H]PAF binding to the PAF-receptor of human platelets
ChEMBL 453 7 0 6 5.7 COc1cc(CCc2ccc(-c3cc4ccccc4c4nnc(C)n34)cc2)cc(OC)c1OC 10.1021/jm00073a008
10841126 67132 0 None - 1 Guinea pig 9.8 pKi = 9.8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 589 6 0 8 6.1 COC(=O)c1cc(-c2ccc(F)cc2)cc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL174592 67132 0 None - 1 Guinea pig 9.8 pKi = 9.8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 589 6 0 8 6.1 COC(=O)c1cc(-c2ccc(F)cc2)cc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
108156 9767 52 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrsDisplacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrs
ChEMBL 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 10.1016/j.bmcl.2013.01.025
1831 9767 52 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrsDisplacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrs
ChEMBL 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 10.1016/j.bmcl.2013.01.025
1833 9767 52 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrsDisplacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrs
ChEMBL 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 10.1016/j.bmcl.2013.01.025
CHEMBL1235246 9767 52 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrsDisplacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrs
ChEMBL 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 10.1016/j.bmcl.2013.01.025
DB02261 9767 52 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrsDisplacement of [3H]PAF from platelet activating factor receptor in human platelets after 3 hrs
ChEMBL 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 10.1016/j.bmcl.2013.01.025
10792315 137342 0 None - 1 Guinea pig 9.7 pKi = 9.7 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 530 7 0 9 4.3 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2S(=O)(=O)C(C)C 10.1021/jm970389+
CHEMBL368113 137342 0 None - 1 Guinea pig 9.7 pKi = 9.7 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 530 7 0 9 4.3 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2S(=O)(=O)C(C)C 10.1021/jm970389+
44330466 214463 0 None - 1 Guinea pig 9.4 pKi = 9.4 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 525 4 1 7 6.2 CN(C)C(=O)n1cc(/C(=N/O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL95440 214463 0 None - 1 Guinea pig 9.4 pKi = 9.4 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 525 4 1 7 6.2 CN(C)C(=O)n1cc(/C(=N/O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
9804204 116481 27 None 1 2 Human 9.4 pKi = 9.4 Binding
The compound was evaluated for its binding affinity against PAF receptor in human plateletThe compound was evaluated for its binding affinity against PAF receptor in human platelet
ChEMBL 458 9 0 7 3.4 CCOC(=O)[C@H](CC(C)C)N(C)S(=O)(=O)c1ccc(Cn2c(C)nc3cnccc32)cc1 10.1021/jm970389+
CHEMBL322832 116481 27 None 1 2 Human 9.4 pKi = 9.4 Binding
The compound was evaluated for its binding affinity against PAF receptor in human plateletThe compound was evaluated for its binding affinity against PAF receptor in human platelet
ChEMBL 458 9 0 7 3.4 CCOC(=O)[C@H](CC(C)C)N(C)S(=O)(=O)c1ccc(Cn2c(C)nc3cnccc32)cc1 10.1021/jm970389+
9804204 116481 27 None -1 2 Guinea pig 9.4 pKi = 9.4 Binding
The compound was evaluated for its binding affinity against PAF receptor in rabbit plateletThe compound was evaluated for its binding affinity against PAF receptor in rabbit platelet
ChEMBL 458 9 0 7 3.4 CCOC(=O)[C@H](CC(C)C)N(C)S(=O)(=O)c1ccc(Cn2c(C)nc3cnccc32)cc1 10.1021/jm970389+
CHEMBL322832 116481 27 None -1 2 Guinea pig 9.4 pKi = 9.4 Binding
The compound was evaluated for its binding affinity against PAF receptor in rabbit plateletThe compound was evaluated for its binding affinity against PAF receptor in rabbit platelet
ChEMBL 458 9 0 7 3.4 CCOC(=O)[C@H](CC(C)C)N(C)S(=O)(=O)c1ccc(Cn2c(C)nc3cnccc32)cc1 10.1021/jm970389+
11797983 172660 0 None - 1 Guinea pig 9.3 pKi = 9.3 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 454 6 1 7 4.3 COC(=O)c1[nH]c2cccc(OC)c2c1C(=O)c1ccc(Cn2c(C)nc3cnccc32)cc1 10.1021/jm970389+
CHEMBL424947 172660 0 None - 1 Guinea pig 9.3 pKi = 9.3 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 454 6 1 7 4.3 COC(=O)c1[nH]c2cccc(OC)c2c1C(=O)c1ccc(Cn2c(C)nc3cnccc32)cc1 10.1021/jm970389+
154087 7019 18 None 2 2 Human 9.2 pKi = 9.2 Binding
The compound was evaluated for its binding affinity against PAF receptor in human plateletThe compound was evaluated for its binding affinity against PAF receptor in human platelet
ChEMBL 479 4 0 6 4.6 C#Cc1cccc2c1c(cn2C(=O)N(C)C)C(=O)c1ccc(c(c1)F)Cn1c(C)nc2c1ccnc2 10.1021/jm970389+
1850 7019 18 None 2 2 Human 9.2 pKi = 9.2 Binding
The compound was evaluated for its binding affinity against PAF receptor in human plateletThe compound was evaluated for its binding affinity against PAF receptor in human platelet
ChEMBL 479 4 0 6 4.6 C#Cc1cccc2c1c(cn2C(=O)N(C)C)C(=O)c1ccc(c(c1)F)Cn1c(C)nc2c1ccnc2 10.1021/jm970389+
CHEMBL369225 7019 18 None 2 2 Human 9.2 pKi = 9.2 Binding
The compound was evaluated for its binding affinity against PAF receptor in human plateletThe compound was evaluated for its binding affinity against PAF receptor in human platelet
ChEMBL 479 4 0 6 4.6 C#Cc1cccc2c1c(cn2C(=O)N(C)C)C(=O)c1ccc(c(c1)F)Cn1c(C)nc2c1ccnc2 10.1021/jm970389+
10767539 66617 0 None - 1 Guinea pig 9.2 pKi = 9.2 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 495 5 0 8 4.4 COC(=O)c1cccc2c1c(C(=O)Cc1ccc(-n3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL172859 66617 0 None - 1 Guinea pig 9.2 pKi = 9.2 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 495 5 0 8 4.4 COC(=O)c1cccc2c1c(C(=O)Cc1ccc(-n3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
154121 175037 2 None - 1 Guinea pig 9.2 pKi = 9.2 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 465 4 1 6 4.3 C#Cc1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)c(F)c1)cn2C(=O)NC 10.1021/jm970389+
CHEMBL433795 175037 2 None - 1 Guinea pig 9.2 pKi = 9.2 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 465 4 1 6 4.3 C#Cc1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)c(F)c1)cn2C(=O)NC 10.1021/jm970389+
44385903 138323 0 None - 1 Guinea pig 9.2 pKi = 9.2 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 522 7 0 8 5.4 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2CC(=O)C(C)(C)C 10.1021/jm970389+
CHEMBL369233 138323 0 None - 1 Guinea pig 9.2 pKi = 9.2 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 522 7 0 8 5.4 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2CC(=O)C(C)(C)C 10.1021/jm970389+
10531810 139359 0 None - 1 Guinea pig 9.1 pKi = 9.1 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 611 6 0 9 6.7 COC(=O)c1cc(-c2cc3ccccc3o2)cc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL369854 139359 0 None - 1 Guinea pig 9.1 pKi = 9.1 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 611 6 0 9 6.7 COC(=O)c1cc(-c2cc3ccccc3o2)cc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
10694900 136455 0 None - 1 Guinea pig 9.1 pKi = 9.1 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 451 4 0 6 4.8 Cc1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL367398 136455 0 None - 1 Guinea pig 9.1 pKi = 9.1 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 451 4 0 6 4.8 Cc1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
10529249 136081 0 None - 1 Guinea pig 9.1 pKi = 9.1 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 495 5 0 8 4.3 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL367085 136081 0 None - 1 Guinea pig 9.1 pKi = 9.1 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 495 5 0 8 4.3 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
10816905 173121 0 None - 1 Guinea pig 9.1 pKi = 9.1 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 571 7 0 8 5.9 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(C(=O)OCc4ccccc4)c23)cc1 10.1021/jm970389+
CHEMBL427307 173121 0 None - 1 Guinea pig 9.1 pKi = 9.1 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 571 7 0 8 5.9 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(C(=O)OCc4ccccc4)c23)cc1 10.1021/jm970389+
10596801 68133 0 None - 1 Guinea pig 9.1 pKi = 9.1 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 394 4 1 4 5.1 Cc1ccc(C)c2c(C(=O)c3ccc(Cn4c(C)nc5cnccc54)cc3)c[nH]c12 10.1021/jm970389+
CHEMBL176797 68133 0 None - 1 Guinea pig 9.1 pKi = 9.1 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 394 4 1 4 5.1 Cc1ccc(C)c2c(C(=O)c3ccc(Cn4c(C)nc5cnccc54)cc3)c[nH]c12 10.1021/jm970389+
10552376 66805 0 None - 1 Guinea pig 9.1 pKi = 9.1 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 471 4 0 6 5.2 Cc1nc2ncccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(Cl)c23)cc1 10.1021/jm970389+
CHEMBL173584 66805 0 None - 1 Guinea pig 9.1 pKi = 9.1 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 471 4 0 6 5.2 Cc1nc2ncccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(Cl)c23)cc1 10.1021/jm970389+
10624048 134980 0 None - 1 Guinea pig 9.0 pKi = 9.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 465 5 0 6 5.1 CCc1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL366553 134980 0 None - 1 Guinea pig 9.0 pKi = 9.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 465 5 0 6 5.1 CCc1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
10791349 67048 0 None - 1 Guinea pig 9.0 pKi = 9.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 494 5 0 7 4.9 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4ccccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL174198 67048 0 None - 1 Guinea pig 9.0 pKi = 9.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 494 5 0 7 4.9 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4ccccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
10793625 136986 0 None - 1 Guinea pig 9.0 pKi = 9.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 595 5 0 8 5.7 COC(=O)c1cc(C#Cc2ccccc2)cc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL367922 136986 0 None - 1 Guinea pig 9.0 pKi = 9.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 595 5 0 8 5.7 COC(=O)c1cc(C#Cc2ccccc2)cc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
1849 7018 3 None 6 2 Human 9.0 pKi = 9.0 Binding
The compound was evaluated for its binding affinity against PAF receptor in human plateletThe compound was evaluated for its binding affinity against PAF receptor in human platelet
ChEMBL 618 6 0 7 2.6 CC(=O)OC[n+]1cccc(c1)[C@H]1SCc2n1ccc2C(=O)c1cn(c2c1ccc(c2)c1ccc(cc1)F)C(=O)N(C)C.[Cl-] 10.1021/jm970389+
9830503 7018 3 None 6 2 Human 9.0 pKi = 9.0 Binding
The compound was evaluated for its binding affinity against PAF receptor in human plateletThe compound was evaluated for its binding affinity against PAF receptor in human platelet
ChEMBL 618 6 0 7 2.6 CC(=O)OC[n+]1cccc(c1)[C@H]1SCc2n1ccc2C(=O)c1cn(c2c1ccc(c2)c1ccc(cc1)F)C(=O)N(C)C.[Cl-] 10.1021/jm970389+
CHEMBL1183764 7018 3 None 6 2 Human 9.0 pKi = 9.0 Binding
The compound was evaluated for its binding affinity against PAF receptor in human plateletThe compound was evaluated for its binding affinity against PAF receptor in human platelet
ChEMBL 618 6 0 7 2.6 CC(=O)OC[n+]1cccc(c1)[C@H]1SCc2n1ccc2C(=O)c1cn(c2c1ccc(c2)c1ccc(cc1)F)C(=O)N(C)C.[Cl-] 10.1021/jm970389+
CHEMBL317090 7018 3 None 6 2 Human 9.0 pKi = 9.0 Binding
The compound was evaluated for its binding affinity against PAF receptor in human plateletThe compound was evaluated for its binding affinity against PAF receptor in human platelet
ChEMBL 618 6 0 7 2.6 CC(=O)OC[n+]1cccc(c1)[C@H]1SCc2n1ccc2C(=O)c1cn(c2c1ccc(c2)c1ccc(cc1)F)C(=O)N(C)C.[Cl-] 10.1021/jm970389+
154087 7019 18 None -2 2 Guinea pig 9.0 pKi = 9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 479 4 0 6 4.6 C#Cc1cccc2c1c(cn2C(=O)N(C)C)C(=O)c1ccc(c(c1)F)Cn1c(C)nc2c1ccnc2 10.1021/jm970389+
1850 7019 18 None -2 2 Guinea pig 9.0 pKi = 9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 479 4 0 6 4.6 C#Cc1cccc2c1c(cn2C(=O)N(C)C)C(=O)c1ccc(c(c1)F)Cn1c(C)nc2c1ccnc2 10.1021/jm970389+
CHEMBL369225 7019 18 None -2 2 Guinea pig 9.0 pKi = 9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 479 4 0 6 4.6 C#Cc1cccc2c1c(cn2C(=O)N(C)C)C(=O)c1ccc(c(c1)F)Cn1c(C)nc2c1ccnc2 10.1021/jm970389+
44297792 107671 0 None - 1 Human 9.0 pKi = 9 Binding
Compound was evaluated for inhibition of binding of [3H]-C18 PAF to human platelet membrane Platelet activating factor receptorCompound was evaluated for inhibition of binding of [3H]-C18 PAF to human platelet membrane Platelet activating factor receptor
ChEMBL 634 14 0 10 5.4 CCCS(=O)(=O)c1cc(C2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCS(=O)(=O)c1ccccc1 10.1016/S0960-894X(01)80446-7
CHEMBL293773 107671 0 None - 1 Human 9.0 pKi = 9 Binding
Compound was evaluated for inhibition of binding of [3H]-C18 PAF to human platelet membrane Platelet activating factor receptorCompound was evaluated for inhibition of binding of [3H]-C18 PAF to human platelet membrane Platelet activating factor receptor
ChEMBL 634 14 0 10 5.4 CCCS(=O)(=O)c1cc(C2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OCCS(=O)(=O)c1ccccc1 10.1016/S0960-894X(01)80446-7
10720080 66808 0 None - 1 Guinea pig 9.0 pKi = 9.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 496 9 0 8 4.8 CCOCCn1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc43)cc2)c2c(C(=O)OC)cccc21 10.1021/jm970389+
CHEMBL173586 66808 0 None - 1 Guinea pig 9.0 pKi = 9.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 496 9 0 8 4.8 CCOCCn1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc43)cc2)c2c(C(=O)OC)cccc21 10.1021/jm970389+
9918334 18733 0 None - 1 Guinea pig 8.9 pKi = 8.9 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 602 22 1 5 8.2 CCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL1182944 18733 0 None - 1 Guinea pig 8.9 pKi = 8.9 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 602 22 1 5 8.2 CCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL273639 18733 0 None - 1 Guinea pig 8.9 pKi = 8.9 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 602 22 1 5 8.2 CCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCC1 10.1016/0960-894X(95)00173-Q
44385287 67146 0 None - 1 Guinea pig 8.9 pKi = 8.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 575 5 0 8 4.0 Cc1nc2cnccc2n1CN1CCN(S(=O)(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)CC1 10.1021/jm970389+
CHEMBL174668 67146 0 None - 1 Guinea pig 8.9 pKi = 8.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 575 5 0 8 4.0 Cc1nc2cnccc2n1CN1CCN(S(=O)(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)CC1 10.1021/jm970389+
10814055 66606 0 None - 1 Guinea pig 8.9 pKi = 8.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 466 6 0 7 5.3 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(C)C 10.1021/jm970389+
CHEMBL172819 66606 0 None - 1 Guinea pig 8.9 pKi = 8.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 466 6 0 7 5.3 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(C)C 10.1021/jm970389+
9847128 66694 0 None - 1 Guinea pig 8.9 pKi = 8.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 461 4 0 6 4.5 C#Cc1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL173122 66694 0 None - 1 Guinea pig 8.9 pKi = 8.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 461 4 0 6 4.5 C#Cc1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
10647650 137038 0 None - 1 Guinea pig 8.9 pKi = 8.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 460 5 1 4 6.3 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2c[nH]c3c(-c4ccc(F)cc4)cccc23)cc1 10.1021/jm970389+
CHEMBL367964 137038 0 None - 1 Guinea pig 8.9 pKi = 8.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 460 5 1 4 6.3 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2c[nH]c3c(-c4ccc(F)cc4)cccc23)cc1 10.1021/jm970389+
10579022 134836 0 None - 1 Guinea pig 8.9 pKi = 8.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 573 5 0 8 5.1 COC(=O)c1cc(Br)cc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL366508 134836 0 None - 1 Guinea pig 8.9 pKi = 8.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 573 5 0 8 5.1 COC(=O)c1cc(Br)cc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
154122 66784 2 None - 1 Guinea pig 8.8 pKi = 8.8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 481 4 1 6 4.5 C#Cc1cccc2c1c(C(O)c1ccc(Cn3c(C)nc4cnccc43)c(F)c1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL173497 66784 2 None - 1 Guinea pig 8.8 pKi = 8.8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 481 4 1 6 4.5 C#Cc1cccc2c1c(C(O)c1ccc(Cn3c(C)nc4cnccc43)c(F)c1)cn2C(=O)N(C)C 10.1021/jm970389+
10719057 135798 0 None - 1 Guinea pig 8.8 pKi = 8.8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 467 5 1 8 3.7 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(N)=O 10.1021/jm970389+
CHEMBL366998 135798 0 None - 1 Guinea pig 8.8 pKi = 8.8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 467 5 1 8 3.7 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(N)=O 10.1021/jm970389+
10672408 138601 0 None - 1 Guinea pig 8.8 pKi = 8.8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 481 5 1 8 3.9 CNC(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc43)cc2)c2c(C(=O)OC)cccc21 10.1021/jm970389+
CHEMBL369395 138601 0 None - 1 Guinea pig 8.8 pKi = 8.8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 481 5 1 8 3.9 CNC(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc43)cc2)c2c(C(=O)OC)cccc21 10.1021/jm970389+
10506156 172835 0 None - 1 Guinea pig 8.8 pKi = 8.8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 520 5 0 7 5.4 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4ccccc43)cc1)cn2C(=O)N1CCCC1 10.1021/jm970389+
CHEMBL425688 172835 0 None - 1 Guinea pig 8.8 pKi = 8.8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 520 5 0 7 5.4 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4ccccc43)cc1)cn2C(=O)N1CCCC1 10.1021/jm970389+
10673768 127504 0 None - 1 Guinea pig 8.7 pKi = 8.7 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 529 5 0 8 4.9 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4c(Cl)nccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL354819 127504 0 None - 1 Guinea pig 8.7 pKi = 8.7 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 529 5 0 8 4.9 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4c(Cl)nccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
154087 7019 18 None -2 2 Guinea pig 8.7 pKi = 8.7 Binding
The compound was evaluated for its binding affinity against PAF receptor in rabbit plateletThe compound was evaluated for its binding affinity against PAF receptor in rabbit platelet
ChEMBL 479 4 0 6 4.6 C#Cc1cccc2c1c(cn2C(=O)N(C)C)C(=O)c1ccc(c(c1)F)Cn1c(C)nc2c1ccnc2 10.1021/jm970389+
1850 7019 18 None -2 2 Guinea pig 8.7 pKi = 8.7 Binding
The compound was evaluated for its binding affinity against PAF receptor in rabbit plateletThe compound was evaluated for its binding affinity against PAF receptor in rabbit platelet
ChEMBL 479 4 0 6 4.6 C#Cc1cccc2c1c(cn2C(=O)N(C)C)C(=O)c1ccc(c(c1)F)Cn1c(C)nc2c1ccnc2 10.1021/jm970389+
CHEMBL369225 7019 18 None -2 2 Guinea pig 8.7 pKi = 8.7 Binding
The compound was evaluated for its binding affinity against PAF receptor in rabbit plateletThe compound was evaluated for its binding affinity against PAF receptor in rabbit platelet
ChEMBL 479 4 0 6 4.6 C#Cc1cccc2c1c(cn2C(=O)N(C)C)C(=O)c1ccc(c(c1)F)Cn1c(C)nc2c1ccnc2 10.1021/jm970389+
197443 18419 5 None - 1 Human 8.7 pKi = 8.7 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 566 15 1 10 4.2 CCCOc1c(OCCCO)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CC(C)=O 10.1021/jm00097a005
CHEMBL118105 18419 5 None - 1 Human 8.7 pKi = 8.7 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 566 15 1 10 4.2 CCCOc1c(OCCCO)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CC(C)=O 10.1021/jm00097a005
44330591 10985 0 None - 1 Guinea pig 8.0 pKi = 8 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 560 8 1 7 5.2 CS(=O)(=O)NCCn1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL100257 10985 0 None - 1 Guinea pig 8.0 pKi = 8 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 560 8 1 7 5.2 CS(=O)(=O)NCCn1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
44330532 174920 0 None - 1 Guinea pig 8.0 pKi = 8 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 493 4 0 7 5.5 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3cccnc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL433015 174920 0 None - 1 Guinea pig 8.0 pKi = 8 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 493 4 0 7 5.5 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3cccnc3)cc21 10.1016/0960-894X(95)00511-Q
10815093 67046 0 None - 1 Guinea pig 8.0 pKi = 8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 495 5 0 8 4.3 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cccnc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL174183 67046 0 None - 1 Guinea pig 8.0 pKi = 8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 495 5 0 8 4.3 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cccnc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
10815934 137002 0 None - 1 Guinea pig 8.0 pKi = 8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 525 6 0 9 4.3 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)c(OC)c1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL367941 137002 0 None - 1 Guinea pig 8.0 pKi = 8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 525 6 0 9 4.3 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)c(OC)c1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL98046 214909 0 None - 1 Guinea pig 7.0 pKi = 7 Binding
Binding affinity for Platelet Activating Factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for Platelet Activating Factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 569 4 1 6 5.8 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3C2=C/[N+](=N/C(N)=O)CC=C2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
44330181 21428 0 None - 1 Guinea pig 7.0 pKi = 7 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 561 8 1 7 5.9 O=C(c1ccn2c1CS[C@@H]2c1cccnc1)c1cn(CCCS(=O)(=O)O)c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00511-Q
CHEMBL1205451 21428 0 None - 1 Guinea pig 7.0 pKi = 7 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 561 8 1 7 5.9 O=C(c1ccn2c1CS[C@@H]2c1cccnc1)c1cn(CCCS(=O)(=O)O)c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00511-Q
CHEMBL98818 21428 0 None - 1 Guinea pig 7.0 pKi = 7 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 561 8 1 7 5.9 O=C(c1ccn2c1CS[C@@H]2c1cccnc1)c1cn(CCCS(=O)(=O)O)c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00511-Q
44370756 175236 0 None - 1 Guinea pig 7.0 pKi = 7 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 532 3 2 10 0.8 C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](OCc6ccccc6)C34C(C(C)(C)C)[C@H]5F)[C@]21O 10.1021/jm0203985
CHEMBL435037 175236 0 None - 1 Guinea pig 7.0 pKi = 7 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 532 3 2 10 0.8 C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](OCc6ccccc6)C34C(C(C)(C)C)[C@H]5F)[C@]21O 10.1021/jm0203985
44325417 214137 0 None - 1 Guinea pig 6.0 pKi = 6 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 443 5 1 5 3.9 O=C(c1ccccc1)c1cccc(NC(=O)[C@@H]2CC(=O)N3[C@H](c4cccnc4)SC[C@@H]23)c1 10.1016/S0960-894X(01)80753-8
CHEMBL93677 214137 0 None - 1 Guinea pig 6.0 pKi = 6 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 443 5 1 5 3.9 O=C(c1ccccc1)c1cccc(NC(=O)[C@@H]2CC(=O)N3[C@H](c4cccnc4)SC[C@@H]23)c1 10.1016/S0960-894X(01)80753-8
44340797 16354 2 None - 1 Human 6.0 pKi = 6 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 372 6 0 5 4.8 COc1ccc([C@H]2O[C@@H](c3ccc(OC)c(OC)c3)[C@H](C)[C@H]2C)cc1OC 10.1021/jm00097a005
CHEMBL112481 16354 2 None - 1 Human 6.0 pKi = 6 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 372 6 0 5 4.8 COc1ccc([C@H]2O[C@@H](c3ccc(OC)c(OC)c3)[C@H](C)[C@H]2C)cc1OC 10.1021/jm00097a005
CHEMBL108714 14266 0 None - 1 Guinea pig 6.0 pKi = 6 Binding
Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor
ChEMBL 327 7 1 6 3.5 CCO/C(O)=C1\C(C)=NC(C)=C(C(=O)OCCSCC)C1C 10.1021/jm00174a017
CHEMBL108295 13319 0 None - 1 Guinea pig 6.0 pKi = 6 Binding
Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor
ChEMBL 327 7 1 6 3.5 CCO/C(O)=C1\C(C)=NC(C)=C(C(=O)OCCSC)C1CC 10.1021/jm00174a017
15208092 18077 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 378 14 0 3 5.6 CCCCCCOc1c(OC)cc(/C=C/CCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL1179261 18077 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 378 14 0 3 5.6 CCCCCCOc1c(OC)cc(/C=C/CCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL66826 18077 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 378 14 0 3 5.6 CCCCCCOc1c(OC)cc(/C=C/CCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
6917920 108226 2 None 1 2 Human 7.0 pKi = 7.0 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 404 8 0 7 4.3 COc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OC 10.1021/jm00097a005
CHEMBL297624 108226 2 None 1 2 Human 7.0 pKi = 7.0 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 404 8 0 7 4.3 COc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OC 10.1021/jm00097a005
6917920 108226 2 None -1 2 Guinea pig 7.0 pKi = 7.0 Binding
Inhibitory concentration required to inhibit PAF binding to rabbit platelet membraneInhibitory concentration required to inhibit PAF binding to rabbit platelet membrane
ChEMBL 404 8 0 7 4.3 COc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OC 10.1016/S0960-894X(01)80818-0
CHEMBL297624 108226 2 None -1 2 Guinea pig 7.0 pKi = 7.0 Binding
Inhibitory concentration required to inhibit PAF binding to rabbit platelet membraneInhibitory concentration required to inhibit PAF binding to rabbit platelet membrane
ChEMBL 404 8 0 7 4.3 COc1cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc(OC)c1OC 10.1016/S0960-894X(01)80818-0
44268192 18732 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 721 25 1 6 8.8 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)N1C(=O)c1ccccc1 10.1016/0960-894X(95)00174-R
CHEMBL1182943 18732 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 721 25 1 6 8.8 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)N1C(=O)c1ccccc1 10.1016/0960-894X(95)00174-R
CHEMBL273638 18732 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 721 25 1 6 8.8 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)N1C(=O)c1ccccc1 10.1016/0960-894X(95)00174-R
CHEMBL108086 12892 0 None - 1 Guinea pig 6.0 pKi = 6.0 Binding
Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor
ChEMBL 313 6 1 6 3.1 CCO/C(O)=C1\C(C)=NC(C)=C(C(=O)OCCSC)C1C 10.1021/jm00174a017
9872676 84970 0 None -2691 17 Human 6.0 pKi = 6.0 Binding
Binding affinity to PAFBinding affinity to PAF
ChEMBL 565 11 2 10 4.8 COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 10.1021/jm060012g
CHEMBL210514 84970 0 None -2691 17 Human 6.0 pKi = 6.0 Binding
Binding affinity to PAFBinding affinity to PAF
ChEMBL 565 11 2 10 4.8 COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1 10.1021/jm060012g
44330445 114090 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 709 7 1 10 6.8 CN(C)C(=O)n1cc(/C(=N/OC(=O)c2ccccc2S(=O)(=O)O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL317335 114090 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 709 7 1 10 6.8 CN(C)C(=O)n1cc(/C(=N/OC(=O)c2ccccc2S(=O)(=O)O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
11800020 66032 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 515 4 0 6 5.3 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(Br)c23)cc1 10.1021/jm970389+
CHEMBL170370 66032 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 515 4 0 6 5.3 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(Br)c23)cc1 10.1021/jm970389+
10744089 66644 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 503 5 0 7 5.8 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(-c4ccco4)c23)cc1 10.1021/jm970389+
CHEMBL172949 66644 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 503 5 0 7 5.8 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(-c4ccco4)c23)cc1 10.1021/jm970389+
10554008 66800 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 521 5 0 8 4.8 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N1CCCC1 10.1021/jm970389+
CHEMBL173571 66800 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 521 5 0 8 4.8 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N1CCCC1 10.1021/jm970389+
10505821 136574 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 508 5 0 7 4.2 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(C(=O)N(C)C)c23)cc1 10.1021/jm970389+
CHEMBL367530 136574 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 508 5 0 7 4.2 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(C(=O)N(C)C)c23)cc1 10.1021/jm970389+
10671691 136771 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 461 7 0 8 4.1 COC(=O)c1cccc2c1c(C(=O)CCCCn1c(C)nc3cnccc31)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL367673 136771 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 461 7 0 8 4.1 COC(=O)c1cccc2c1c(C(=O)CCCCn1c(C)nc3cnccc31)cn2C(=O)N(C)C 10.1021/jm970389+
10101014 17882 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 547 22 0 5 7.0 CCCCCCCCCCCCCCCCOCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL11713 17882 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 547 22 0 5 7.0 CCCCCCCCCCCCCCCCOCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178031 17882 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 547 22 0 5 7.0 CCCCCCCCCCCCCCCCOCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
21463468 17891 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 659 24 1 5 9.8 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178049 17891 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 659 24 1 5 9.8 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL12067 17891 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 659 24 1 5 9.8 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCCCC1 10.1016/0960-894X(95)00173-Q
44330542 215070 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 507 4 1 7 5.6 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3cccc(N)c3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL98990 215070 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 507 4 1 7 5.6 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3cccc(N)c3)cc21 10.1016/0960-894X(95)00511-Q
10625050 137700 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 495 5 0 8 4.3 COC(=O)c1ccc2c(c1)c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL368586 137700 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 495 5 0 8 4.3 COC(=O)c1ccc2c(c1)c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
44370797 171645 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 458 0 3 10 -1.2 C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](O)C34C(C(C)(C)C)[C@H]5Cl)[C@]21O 10.1021/jm0203985
CHEMBL422003 171645 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 458 0 3 10 -1.2 C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](O)C34C(C(C)(C)C)[C@H]5Cl)[C@]21O 10.1021/jm0203985
10484341 21572 0 None - 1 Human 7.0 pKi = 7.0 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 646 17 2 11 4.3 CCCOc1c(OCCCOP(=O)(O)O)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CC(C)=O 10.1021/jm00097a005
CHEMBL1206922 21572 0 None - 1 Human 7.0 pKi = 7.0 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 646 17 2 11 4.3 CCCOc1c(OCCCOP(=O)(O)O)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CC(C)=O 10.1021/jm00097a005
CHEMBL325491 21572 0 None - 1 Human 7.0 pKi = 7.0 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 646 17 2 11 4.3 CCCOc1c(OCCCOP(=O)(O)O)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CC(C)=O 10.1021/jm00097a005
21463470 17895 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 587 26 1 4 9.2 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCC[n+]2ccccc2)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178059 17895 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 587 26 1 4 9.2 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCC[n+]2ccccc2)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL12337 17895 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 587 26 1 4 9.2 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCC[n+]2ccccc2)CCCC1 10.1016/0960-894X(95)00173-Q
18755202 15646 5 None - 1 Human 6.9 pKi = 6.9 Binding
Compound was tested for it''s ability to inhibit [3H]C18-PAF binding to human plateletCompound was tested for it''s ability to inhibit [3H]C18-PAF binding to human platelet
ChEMBL 510 12 1 9 3.9 CCCOc1c(OC)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO 10.1016/S0960-894X(01)80818-0
CHEMBL109738 15646 5 None - 1 Human 6.9 pKi = 6.9 Binding
Compound was tested for it''s ability to inhibit [3H]C18-PAF binding to human plateletCompound was tested for it''s ability to inhibit [3H]C18-PAF binding to human platelet
ChEMBL 510 12 1 9 3.9 CCCOc1c(OC)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO 10.1016/S0960-894X(01)80818-0
12800741 209700 0 None - 1 Guinea pig 4.9 pKi = 4.9 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 395 5 2 3 5.6 CC(CCCc1ccc(F)cc1)c1cc(O)c2c(c1)OC(C)(C)C1=C2CNCC1 10.1021/jm00089a016
CHEMBL62822 209700 0 None - 1 Guinea pig 4.9 pKi = 4.9 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 395 5 2 3 5.6 CC(CCCc1ccc(F)cc1)c1cc(O)c2c(c1)OC(C)(C)C1=C2CNCC1 10.1021/jm00089a016
10504663 127186 0 None - 1 Guinea pig 7.9 pKi = 7.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 473 4 0 7 4.1 Cc1nc2cnccc2n1Cc1ccc(S(=O)(=O)c2cn(C(=O)N(C)C)c3ccccc23)cc1 10.1021/jm970389+
CHEMBL353618 127186 0 None - 1 Guinea pig 7.9 pKi = 7.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 473 4 0 7 4.1 Cc1nc2cnccc2n1Cc1ccc(S(=O)(=O)c2cn(C(=O)N(C)C)c3ccccc23)cc1 10.1021/jm970389+
10695777 137455 0 None - 1 Guinea pig 7.9 pKi = 7.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 472 7 1 5 6.1 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2c[nH]c3c(OCc4ccccc4)cccc23)cc1 10.1021/jm970389+
CHEMBL368292 137455 0 None - 1 Guinea pig 7.9 pKi = 7.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 472 7 1 5 6.1 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2c[nH]c3c(OCc4ccccc4)cccc23)cc1 10.1021/jm970389+
CHEMBL98090 214921 0 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 631 5 0 7 6.9 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3C2=C/[N+](=N/C(=O)c3cccnc3)CC=C2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
44385343 67178 0 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 561 4 0 8 3.7 Cc1nc2cnccc2n1N1CCN(S(=O)(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)CC1 10.1021/jm970389+
CHEMBL174989 67178 0 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 561 4 0 8 3.7 Cc1nc2cnccc2n1N1CCN(S(=O)(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)CC1 10.1021/jm970389+
11800192 137997 0 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 523 5 0 8 4.9 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4c(C)nc(C)cc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL368657 137997 0 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 523 5 0 8 4.9 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4c(C)nc(C)cc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
44370939 126272 0 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 514 3 2 10 0.9 C[C@@H]1C(=O)OC2[C@H](O)C34C5CC(C(C)(C)C)C36C(OC(=O)[C@@H]6OCc3ccccc3)OC4(C(=O)O5)[C@]21O 10.1021/jm0203985
CHEMBL345420 126272 0 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 514 3 2 10 0.9 C[C@@H]1C(=O)OC2[C@H](O)C34C5CC(C(C)(C)C)C36C(OC(=O)[C@@H]6OCc3ccccc3)OC4(C(=O)O5)[C@]21O 10.1021/jm0203985
44325488 214090 0 None - 1 Guinea pig 5.9 pKi = 5.9 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 445 5 1 6 3.9 O=C(c1ccccc1)c1cccc(NC(=O)[C@@H]2OC(=O)N3[C@@H](c4cccnc4)SC[C@@H]23)c1 10.1016/S0960-894X(01)80753-8
CHEMBL93374 214090 0 None - 1 Guinea pig 5.9 pKi = 5.9 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 445 5 1 6 3.9 O=C(c1ccccc1)c1cccc(NC(=O)[C@@H]2OC(=O)N3[C@@H](c4cccnc4)SC[C@@H]23)c1 10.1016/S0960-894X(01)80753-8
10459615 19154 0 None - 1 Guinea pig 5.9 pKi = 5.9 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 402 11 0 5 3.9 COc1cc(C(=O)OCCCC[N+](C)(C)C)cc(OC)c1OCc1ccccc1 10.1021/jm00012a012
CHEMBL1185612 19154 0 None - 1 Guinea pig 5.9 pKi = 5.9 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 402 11 0 5 3.9 COc1cc(C(=O)OCCCC[N+](C)(C)C)cc(OC)c1OCc1ccccc1 10.1021/jm00012a012
CHEMBL423305 19154 0 None - 1 Guinea pig 5.9 pKi = 5.9 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 402 11 0 5 3.9 COc1cc(C(=O)OCCCC[N+](C)(C)C)cc(OC)c1OCc1ccccc1 10.1021/jm00012a012
44353137 176051 0 None - 1 Mouse 4.9 pKi = 4.9 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 456 1 4 11 -1.9 COC1OC(=O)[C@H](O)C12[C@H](C(C)(C)C)[C@@H](O)C1OC(=O)C3[C@@]4(O)[C@H](C)C(=O)O[C@H]4[C@H](O)[C@]132 10.1021/jm020147w
CHEMBL441286 176051 0 None - 1 Mouse 4.9 pKi = 4.9 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 456 1 4 11 -1.9 COC1OC(=O)[C@H](O)C12[C@H](C(C)(C)C)[C@@H](O)C1OC(=O)C3[C@@]4(O)[C@H](C)C(=O)O[C@H]4[C@H](O)[C@]132 10.1021/jm020147w
16211418 73761 6 None - 1 Guinea pig 4.9 pKi = 4.9 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 440 0 4 11 -2.4 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@]34[C@@H]5OC(=O)[C@]3(OC3OC(=O)[C@H](O)C34[C@H](C(C)(C)C)[C@@H]5O)[C@@]12O 10.1021/jm0203985
CHEMBL1868593 73761 6 None - 1 Guinea pig 4.9 pKi = 4.9 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 440 0 4 11 -2.4 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@]34[C@@H]5OC(=O)[C@]3(OC3OC(=O)[C@H](O)C34[C@H](C(C)(C)C)[C@@H]5O)[C@@]12O 10.1021/jm0203985
44267821 17890 0 None - 1 Guinea pig 7.9 pKi = 7.9 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 604 24 1 5 8.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(C)(C)COC(=O)N(Cc1cccc[n+]1CC)C(C)=O 10.1016/0960-894X(95)00173-Q
CHEMBL1178046 17890 0 None - 1 Guinea pig 7.9 pKi = 7.9 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 604 24 1 5 8.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(C)(C)COC(=O)N(Cc1cccc[n+]1CC)C(C)=O 10.1016/0960-894X(95)00173-Q
CHEMBL12012 17890 0 None - 1 Guinea pig 7.9 pKi = 7.9 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 604 24 1 5 8.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(C)(C)COC(=O)N(Cc1cccc[n+]1CC)C(C)=O 10.1016/0960-894X(95)00173-Q
10768575 67047 0 None - 1 Guinea pig 7.9 pKi = 7.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 531 5 0 9 3.9 COC(=O)c1cccc2c1c(S(=O)(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL174192 67047 0 None - 1 Guinea pig 7.9 pKi = 7.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 531 5 0 9 3.9 COC(=O)c1cccc2c1c(S(=O)(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
44330383 114926 0 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 540 6 2 7 5.3 O=C(O)CNC(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL319603 114926 0 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 540 6 2 7 5.3 O=C(O)CNC(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
44353073 123136 0 None - 1 Mouse 6.9 pKi = 6.9 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 632 4 2 12 1.7 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34C5C[C@@H](C(C)(C)C)C36C(OC(=O)[C@@H]6OC(=O)c3ccc(C(=O)c6ccccc6)cc3)OC4(C(=O)O5)[C@@]12O 10.1021/jm020147w
CHEMBL335974 123136 0 None - 1 Mouse 6.9 pKi = 6.9 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 632 4 2 12 1.7 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34C5C[C@@H](C(C)(C)C)C36C(OC(=O)[C@@H]6OC(=O)c3ccc(C(=O)c6ccccc6)cc3)OC4(C(=O)O5)[C@@]12O 10.1021/jm020147w
10004583 18080 0 None - 1 Guinea pig 4.9 pKi = 4.9 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 336 12 0 3 4.3 CCCCCCOc1ccc(C(=O)OCCCC[N+](C)(C)C)cc1 10.1021/jm00012a012
CHEMBL1179268 18080 0 None - 1 Guinea pig 4.9 pKi = 4.9 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 336 12 0 3 4.3 CCCCCCOc1ccc(C(=O)OCCCC[N+](C)(C)C)cc1 10.1021/jm00012a012
CHEMBL67031 18080 0 None - 1 Guinea pig 4.9 pKi = 4.9 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 336 12 0 3 4.3 CCCCCCOc1ccc(C(=O)OCCCC[N+](C)(C)C)cc1 10.1021/jm00012a012
21463389 18745 0 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 593 26 1 5 9.3 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCC[n+]2ccsc2)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL1183002 18745 0 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 593 26 1 5 9.3 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCC[n+]2ccsc2)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL275573 18745 0 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 593 26 1 5 9.3 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCC[n+]2ccsc2)CCCC1 10.1016/0960-894X(95)00173-Q
10743377 66837 0 None - 1 Guinea pig 7.9 pKi = 7.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 481 5 1 7 4.2 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(C(=O)O)c23)cc1 10.1021/jm970389+
CHEMBL173742 66837 0 None - 1 Guinea pig 7.9 pKi = 7.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 481 5 1 7 4.2 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(C(=O)O)c23)cc1 10.1021/jm970389+
5312127 70093 1 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro inhibition of [3H]-C18 PAF binding to human platelet membrane Platelet activating factor receptor was determinedIn vitro inhibition of [3H]-C18 PAF binding to human platelet membrane Platelet activating factor receptor was determined
ChEMBL 480 10 0 8 4.5 CCCOc1c(OC)cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(C)(=O)=O 10.1016/S0960-894X(01)80446-7
CHEMBL1793831 70093 1 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro inhibition of [3H]-C18 PAF binding to human platelet membrane Platelet activating factor receptor was determinedIn vitro inhibition of [3H]-C18 PAF binding to human platelet membrane Platelet activating factor receptor was determined
ChEMBL 480 10 0 8 4.5 CCCOc1c(OC)cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(C)(=O)=O 10.1016/S0960-894X(01)80446-7
44268128 17907 0 None - 1 Guinea pig 7.8 pKi = 7.8 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 547 22 0 5 7.1 CCCCCCCCCCCCCCCCOC[C@@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL1178084 17907 0 None - 1 Guinea pig 7.8 pKi = 7.8 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 547 22 0 5 7.1 CCCCCCCCCCCCCCCCOC[C@@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL12836 17907 0 None - 1 Guinea pig 7.8 pKi = 7.8 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 547 22 0 5 7.1 CCCCCCCCCCCCCCCCOC[C@@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
10625951 68060 0 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 526 8 0 7 5.2 Cc1nc2cnccc2n1CCCN(C)CC(=O)c1cn(C(=O)N(C)C)c2cc(-c3ccc(F)cc3)ccc12 10.1021/jm970389+
CHEMBL176678 68060 0 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 526 8 0 7 5.2 Cc1nc2cnccc2n1CCCN(C)CC(=O)c1cn(C(=O)N(C)C)c2cc(-c3ccc(F)cc3)ccc12 10.1021/jm970389+
44325031 214071 0 None - 1 Guinea pig 4.9 pKi = 4.9 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 458 5 1 5 3.8 CN1C(=O)N2[C@H](c3cccnc3)SC[C@H]2[C@@H]1C(=O)Nc1cccc(C(=O)c2ccccc2)c1 10.1016/S0960-894X(01)80753-8
CHEMBL93223 214071 0 None - 1 Guinea pig 4.9 pKi = 4.9 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 458 5 1 5 3.8 CN1C(=O)N2[C@H](c3cccnc3)SC[C@H]2[C@@H]1C(=O)Nc1cccc(C(=O)c2ccccc2)c1 10.1016/S0960-894X(01)80753-8
10372227 18082 1 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 536 24 0 5 8.2 CCCCCCCCCCCCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL1179274 18082 1 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 536 24 0 5 8.2 CCCCCCCCCCCCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL67302 18082 1 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 536 24 0 5 8.2 CCCCCCCCCCCCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
14983489 210136 0 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 480 8 1 4 5.3 CNC(=O)CN1CCC2=C(C1)c1c(OC)cc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
CHEMBL65132 210136 0 None - 1 Guinea pig 6.9 pKi = 6.9 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 480 8 1 4 5.3 CNC(=O)CN1CCC2=C(C1)c1c(OC)cc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
44325151 213565 0 None - 1 Guinea pig 5.8 pKi = 5.8 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 458 5 1 5 3.8 CN1C(=O)N2[C@@H](c3cccnc3)SC[C@H]2[C@H]1C(=O)Nc1cccc(C(=O)c2ccccc2)c1 10.1016/S0960-894X(01)80753-8
CHEMBL90243 213565 0 None - 1 Guinea pig 5.8 pKi = 5.8 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 458 5 1 5 3.8 CN1C(=O)N2[C@@H](c3cccnc3)SC[C@H]2[C@H]1C(=O)Nc1cccc(C(=O)c2ccccc2)c1 10.1016/S0960-894X(01)80753-8
44353034 172054 0 None - 1 Mouse 5.8 pKi = 5.8 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 424 1 2 9 0.2 COC1OC(=O)[C@H](O)C12[C@H](C(C)(C)C)CC1OC(=O)C3[C@]4(O)[C@H](C[C@]132)OC(=O)[C@H]4C 10.1021/jm020147w
CHEMBL423154 172054 0 None - 1 Mouse 5.8 pKi = 5.8 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 424 1 2 9 0.2 COC1OC(=O)[C@H](O)C12[C@H](C(C)(C)C)CC1OC(=O)C3[C@]4(O)[C@H](C[C@]132)OC(=O)[C@H]4C 10.1021/jm020147w
10528709 66791 0 None - 1 Guinea pig 7.8 pKi = 7.8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 479 8 0 7 4.9 CCOCCn1cc(C(=O)CN2CCC(n3c(C)nc4cnccc43)CC2)c2c(Cl)cccc21 10.1021/jm970389+
CHEMBL173531 66791 0 None - 1 Guinea pig 7.8 pKi = 7.8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 479 8 0 7 4.9 CCOCCn1cc(C(=O)CN2CCC(n3c(C)nc4cnccc43)CC2)c2c(Cl)cccc21 10.1021/jm970389+
44268122 17900 0 None - 1 Guinea pig 7.8 pKi = 7.8 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL1178068 17900 0 None - 1 Guinea pig 7.8 pKi = 7.8 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL12439 17900 0 None - 1 Guinea pig 7.8 pKi = 7.8 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL12882 17900 0 None - 1 Guinea pig 7.8 pKi = 7.8 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL107881 12574 0 None - 1 Guinea pig 7.8 pKi = 7.8 Binding
Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor
ChEMBL 361 6 1 6 4.1 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)OCCSc2ccccc2)C1C 10.1021/jm00174a017
44353136 27113 0 None - 1 Mouse 6.8 pKi = 6.8 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 618 5 2 11 2.1 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34C5C[C@@H](C(C)(C)C)C36C(OC(=O)[C@@H]6OCc3ccc(C(=O)c6ccccc6)cc3)OC4(C(=O)O5)[C@@]12O 10.1021/jm020147w
CHEMBL130606 27113 0 None - 1 Mouse 6.8 pKi = 6.8 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 618 5 2 11 2.1 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34C5C[C@@H](C(C)(C)C)C36C(OC(=O)[C@@H]6OCc3ccc(C(=O)c6ccccc6)cc3)OC4(C(=O)O5)[C@@]12O 10.1021/jm020147w
44353135 123834 0 None - 1 Mouse 6.8 pKi = 6.8 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 622 4 2 12 2.0 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34C5C[C@@H](C(C)(C)C)C36C(OC(=O)[C@@H]6OCc3ccc(C6(C(F)(F)F)N=N6)cc3)OC4(C(=O)O5)[C@@]12O 10.1021/jm020147w
CHEMBL339146 123834 0 None - 1 Mouse 6.8 pKi = 6.8 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 622 4 2 12 2.0 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34C5C[C@@H](C(C)(C)C)C36C(OC(=O)[C@@H]6OCc3ccc(C6(C(F)(F)F)N=N6)cc3)OC4(C(=O)O5)[C@@]12O 10.1021/jm020147w
44325131 214188 0 None - 1 Guinea pig 6.8 pKi = 6.8 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 445 5 1 6 3.9 O=C(c1ccccc1)c1cccc(NC(=O)[C@H]2OC(=O)N3[C@H](c4cccnc4)SC[C@@H]23)c1 10.1016/S0960-894X(01)80753-8
CHEMBL93952 214188 0 None - 1 Guinea pig 6.8 pKi = 6.8 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 445 5 1 6 3.9 O=C(c1ccccc1)c1cccc(NC(=O)[C@H]2OC(=O)N3[C@H](c4cccnc4)SC[C@@H]23)c1 10.1016/S0960-894X(01)80753-8
14983485 103529 0 None - 1 Guinea pig 6.8 pKi = 6.8 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 551 10 1 5 4.8 CNC(=O)CN1CCC2=C(C1)c1c(OCC(=O)N(C)C)cc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
CHEMBL264497 103529 0 None - 1 Guinea pig 6.8 pKi = 6.8 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 551 10 1 5 4.8 CNC(=O)CN1CCC2=C(C1)c1c(OCC(=O)N(C)C)cc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
44305015 210151 0 None - 1 Guinea pig 5.8 pKi = 5.8 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 454 9 2 4 4.9 CNC(=O)CN(C)CC1=CC(C)(C)Oc2cc(C(C)CCCc3ccc(F)cc3)cc(O)c21 10.1021/jm00089a016
CHEMBL65228 210151 0 None - 1 Guinea pig 5.8 pKi = 5.8 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 454 9 2 4 4.9 CNC(=O)CN(C)CC1=CC(C)(C)Oc2cc(C(C)CCCc3ccc(F)cc3)cc(O)c21 10.1021/jm00089a016
21321141 108979 0 None - 1 Guinea pig 4.8 pKi = 4.8 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 480 7 1 4 5.4 CC(CCCc1ccc(F)cc1)c1cc(O)c2c(c1)OC(C)(C)C1=C2CN(CC(=O)N(C)C)CC1 10.1021/jm00089a016
CHEMBL302863 108979 0 None - 1 Guinea pig 4.8 pKi = 4.8 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 480 7 1 4 5.4 CC(CCCc1ccc(F)cc1)c1cc(O)c2c(c1)OC(C)(C)C1=C2CN(CC(=O)N(C)C)CC1 10.1021/jm00089a016
9985047 18073 0 None - 1 Guinea pig 5.8 pKi = 5.8 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 424 16 0 5 5.1 CCCCCCCCCCOc1c(OC)cc(C(=O)OCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL1179248 18073 0 None - 1 Guinea pig 5.8 pKi = 5.8 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 424 16 0 5 5.1 CCCCCCCCCCOc1c(OC)cc(C(=O)OCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL66344 18073 0 None - 1 Guinea pig 5.8 pKi = 5.8 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 424 16 0 5 5.1 CCCCCCCCCCOc1c(OC)cc(C(=O)OCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
44330533 215083 0 None - 1 Guinea pig 7.8 pKi = 7.8 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 522 5 1 7 5.6 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(CO)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL99070 215083 0 None - 1 Guinea pig 7.8 pKi = 7.8 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 522 5 1 7 5.6 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(CO)cc3)cc21 10.1016/0960-894X(95)00511-Q
10672861 66773 0 None - 1 Guinea pig 7.8 pKi = 7.8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 495 5 0 8 4.3 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4ccncc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL173471 66773 0 None - 1 Guinea pig 7.8 pKi = 7.8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 495 5 0 8 4.3 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4ccncc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
44330473 114030 0 None - 1 Guinea pig 6.8 pKi = 6.8 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 610 9 0 8 6.7 CN(C)CCCO/N=C(\c1ccn2c1CS[C@@H]2c1cccnc1)c1cn(C(=O)N(C)C)c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00511-Q
CHEMBL316911 114030 0 None - 1 Guinea pig 6.8 pKi = 6.8 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 610 9 0 8 6.7 CN(C)CCCO/N=C(\c1ccn2c1CS[C@@H]2c1cccnc1)c1cn(C(=O)N(C)C)c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00511-Q
44330573 114704 0 None - 1 Guinea pig 6.8 pKi = 6.8 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 511 7 1 6 6.1 O=C(O)CCn1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL319346 114704 0 None - 1 Guinea pig 6.8 pKi = 6.8 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 511 7 1 6 6.1 O=C(O)CCn1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
44370951 174991 0 None - 1 Guinea pig 5.8 pKi = 5.8 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 467 2 4 11 -1.8 CCN[C@@H]1C(C(C)(C)C)C23C(OC(=O)[C@@H]2O)OC24C(=O)OC1C32[C@@H](O)C1OC(=O)[C@@H](C)[C@@]14O 10.1021/jm0203985
CHEMBL433516 174991 0 None - 1 Guinea pig 5.8 pKi = 5.8 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 467 2 4 11 -1.8 CCN[C@@H]1C(C(C)(C)C)C23C(OC(=O)[C@@H]2O)OC24C(=O)OC1C32[C@@H](O)C1OC(=O)[C@@H](C)[C@@]14O 10.1021/jm0203985
14983484 209711 0 None - 1 Guinea pig 6.8 pKi = 6.8 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 537 10 2 5 4.5 CNC(=O)COc1cc(C(C)CCCc2ccc(F)cc2)cc2c1C1=C(CCN(CC(=O)NC)C1)C(C)(C)O2 10.1021/jm00089a016
CHEMBL62873 209711 0 None - 1 Guinea pig 6.8 pKi = 6.8 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 537 10 2 5 4.5 CNC(=O)COc1cc(C(C)CCCc2ccc(F)cc2)cc2c1C1=C(CCN(CC(=O)NC)C1)C(C)(C)O2 10.1021/jm00089a016
44370757 57963 0 None - 1 Guinea pig 5.8 pKi = 5.8 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 530 3 3 11 -0.2 C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](OCc6ccccc6)C34C(C(C)(C)C)[C@@H]5O)[C@]21O 10.1021/jm0203985
CHEMBL158006 57963 0 None - 1 Guinea pig 5.8 pKi = 5.8 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 530 3 3 11 -0.2 C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](OCc6ccccc6)C34C(C(C)(C)C)[C@@H]5O)[C@]21O 10.1021/jm0203985
14983486 209591 0 None - 1 Guinea pig 4.8 pKi = 4.8 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 409 6 1 3 5.9 COc1cc(C(C)CCCc2ccc(F)cc2)cc2c1C1=C(CCNC1)C(C)(C)O2 10.1021/jm00089a016
CHEMBL62322 209591 0 None - 1 Guinea pig 4.8 pKi = 4.8 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 409 6 1 3 5.9 COc1cc(C(C)CCCc2ccc(F)cc2)cc2c1C1=C(CCNC1)C(C)(C)O2 10.1021/jm00089a016
10484341 21572 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationIn vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparation
ChEMBL 646 17 2 11 4.3 CCCOc1c(OCCCOP(=O)(O)O)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CC(C)=O 10.1021/jm00097a005
CHEMBL1206922 21572 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationIn vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparation
ChEMBL 646 17 2 11 4.3 CCCOc1c(OCCCOP(=O)(O)O)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CC(C)=O 10.1021/jm00097a005
CHEMBL325491 21572 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationIn vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparation
ChEMBL 646 17 2 11 4.3 CCCOc1c(OCCCOP(=O)(O)O)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CC(C)=O 10.1021/jm00097a005
44330543 214961 0 None - 1 Guinea pig 7.8 pKi = 7.8 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 497 6 1 6 5.8 O=C(O)Cn1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL98359 214961 0 None - 1 Guinea pig 7.8 pKi = 7.8 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 497 6 1 6 5.8 O=C(O)Cn1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
10649918 172986 0 None - 1 Guinea pig 6.8 pKi = 6.8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 531 5 0 6 6.3 Cc1nc2cnccc2n1Cc1cccc(C(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)c1 10.1021/jm970389+
CHEMBL426579 172986 0 None - 1 Guinea pig 6.8 pKi = 6.8 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 531 5 0 6 6.3 Cc1nc2cnccc2n1Cc1cccc(C(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)c1 10.1021/jm970389+
44325243 119406 0 None - 1 Guinea pig 5.8 pKi = 5.8 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 443 5 1 5 3.9 O=C(c1ccccc1)c1cccc(NC(=O)[C@@H]2CC(=O)N3[C@@H](c4cccnc4)SC[C@@H]23)c1 10.1016/S0960-894X(01)80753-8
CHEMBL330269 119406 0 None - 1 Guinea pig 5.8 pKi = 5.8 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 443 5 1 5 3.9 O=C(c1ccccc1)c1cccc(NC(=O)[C@@H]2CC(=O)N3[C@@H](c4cccnc4)SC[C@@H]23)c1 10.1016/S0960-894X(01)80753-8
10053949 18070 0 None - 1 Guinea pig 6.7 pKi = 6.7 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 452 18 0 5 5.9 CCCCCCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL1179244 18070 0 None - 1 Guinea pig 6.7 pKi = 6.7 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 452 18 0 5 5.9 CCCCCCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL66185 18070 0 None - 1 Guinea pig 6.7 pKi = 6.7 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 452 18 0 5 5.9 CCCCCCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
44267841 17888 0 None - 1 Guinea pig 6.7 pKi = 6.7 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 589 27 1 5 8.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccccc2)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178044 17888 0 None - 1 Guinea pig 6.7 pKi = 6.7 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 589 27 1 5 8.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccccc2)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL11977 17888 0 None - 1 Guinea pig 6.7 pKi = 6.7 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 589 27 1 5 8.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccccc2)COC1 10.1016/0960-894X(95)00173-Q
44330129 114933 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 521 6 0 9 5.2 O=C(c1ccn2c1CS[C@@H]2c1cccnc1)c1cn(Cn2ncnn2)c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00511-Q
CHEMBL319609 114933 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 521 6 0 9 5.2 O=C(c1ccn2c1CS[C@@H]2c1cccnc1)c1cn(Cn2ncnn2)c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00511-Q
10767781 66236 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 502 5 0 9 3.5 COC(=O)c1cccc2c1c(C(=O)CN1CCC(n3c(C)nc4cnccc43)CC1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL171294 66236 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 502 5 0 9 3.5 COC(=O)c1cccc2c1c(C(=O)CN1CCC(n3c(C)nc4cnccc43)CC1)cn2C(=O)N(C)C 10.1021/jm970389+
10767535 137480 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 495 4 0 6 3.9 C#Cc1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4c[n+]([O-])ccc43)c(F)c1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL368410 137480 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 495 4 0 6 3.9 C#Cc1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4c[n+]([O-])ccc43)c(F)c1)cn2C(=O)N(C)C 10.1021/jm970389+
10649919 135799 0 None - 1 Guinea pig 6.7 pKi = 6.7 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 531 5 0 6 6.3 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3ccc(-c4ccc(F)cc4)cc23)cc1 10.1021/jm970389+
CHEMBL367011 135799 0 None - 1 Guinea pig 6.7 pKi = 6.7 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 531 5 0 6 6.3 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3ccc(-c4ccc(F)cc4)cc23)cc1 10.1021/jm970389+
10008088 18078 0 None - 1 Guinea pig 6.7 pKi = 6.7 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 438 17 0 5 5.5 CCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](CC)(CC)CC)cc1OC 10.1021/jm00012a012
CHEMBL1179264 18078 0 None - 1 Guinea pig 6.7 pKi = 6.7 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 438 17 0 5 5.5 CCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](CC)(CC)CC)cc1OC 10.1021/jm00012a012
CHEMBL66933 18078 0 None - 1 Guinea pig 6.7 pKi = 6.7 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 438 17 0 5 5.5 CCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](CC)(CC)CC)cc1OC 10.1021/jm00012a012
2753 126128 67 None - 1 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)
ChEMBL 342 6 1 4 3.9 CN(C(=O)CCCOc1ccc2nc(O)ccc2c1)C1CCCCC1 nan
CHEMBL34431 126128 67 None - 1 Human 5.7 pKi = 5.7 Binding
DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)
ChEMBL 342 6 1 4 3.9 CN(C(=O)CCCOc1ccc2nc(O)ccc2c1)C1CCCCC1 nan
10504086 66521 0 None - 1 Guinea pig 8.7 pKi = 8.7 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 458 4 0 7 4.1 Cc1cccc2c1c(C(=O)CN1CCC(n3c(C)nc4cnccc43)CC1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL172484 66521 0 None - 1 Guinea pig 8.7 pKi = 8.7 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 458 4 0 7 4.1 Cc1cccc2c1c(C(=O)CN1CCC(n3c(C)nc4cnccc43)CC1)cn2C(=O)N(C)C 10.1021/jm970389+
10721536 67082 0 None - 1 Guinea pig 8.7 pKi = 8.7 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 556 6 1 7 5.8 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(NC(=O)c4ccccc4)c23)cc1 10.1021/jm970389+
CHEMBL174402 67082 0 None - 1 Guinea pig 8.7 pKi = 8.7 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 556 6 1 7 5.8 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(NC(=O)c4ccccc4)c23)cc1 10.1021/jm970389+
10790411 138901 0 None - 1 Guinea pig 8.7 pKi = 8.7 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 467 5 0 7 4.5 COc1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL369614 138901 0 None - 1 Guinea pig 8.7 pKi = 8.7 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 467 5 0 7 4.5 COc1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
10811407 67163 0 None - 1 Guinea pig 8.7 pKi = 8.7 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 408 4 1 4 4.6 C#Cc1cccc2[nH]cc(C(=O)c3ccc(Cn4c(C)nc5cnccc54)c(F)c3)c12 10.1021/jm970389+
CHEMBL174859 67163 0 None - 1 Guinea pig 8.7 pKi = 8.7 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 408 4 1 4 4.6 C#Cc1cccc2[nH]cc(C(=O)c3ccc(Cn4c(C)nc5cnccc54)c(F)c3)c12 10.1021/jm970389+
10369605 114145 0 None -1 2 Guinea pig 8.6 pKi = 8.6 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 526 4 0 6 5.4 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2ccc[n+]([O-])c2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL317745 114145 0 None -1 2 Guinea pig 8.6 pKi = 8.6 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 526 4 0 6 5.4 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2ccc[n+]([O-])c2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
10602310 68109 0 None - 1 Guinea pig 8.6 pKi = 8.6 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 531 5 0 6 6.3 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)cc1 10.1021/jm970389+
CHEMBL176725 68109 0 None - 1 Guinea pig 8.6 pKi = 8.6 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 531 5 0 6 6.3 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)cc1 10.1021/jm970389+
10369605 114145 0 None 1 2 Rat 8.6 pKi = 8.6 Binding
Inhibition of platelet activating factor(PAF) by binding to PAF receptorInhibition of platelet activating factor(PAF) by binding to PAF receptor
ChEMBL 526 4 0 6 5.4 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2ccc[n+]([O-])c2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00510-Z
CHEMBL317745 114145 0 None 1 2 Rat 8.6 pKi = 8.6 Binding
Inhibition of platelet activating factor(PAF) by binding to PAF receptorInhibition of platelet activating factor(PAF) by binding to PAF receptor
ChEMBL 526 4 0 6 5.4 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2ccc[n+]([O-])c2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00510-Z
10696765 137400 0 None - 1 Guinea pig 8.6 pKi = 8.6 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 501 5 0 8 4.7 COC(=O)c1cccc2c1c(C(=O)C1CCC(Cn3c(C)nc4cnccc43)CC1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL368185 137400 0 None - 1 Guinea pig 8.6 pKi = 8.6 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 501 5 0 8 4.7 COC(=O)c1cccc2c1c(C(=O)C1CCC(Cn3c(C)nc4cnccc43)CC1)cn2C(=O)N(C)C 10.1021/jm970389+
10554403 66819 0 None - 1 Guinea pig 8.6 pKi = 8.6 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 538 4 0 6 5.6 Cc1nc2cnccc2n1CC1CCN(C(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)CC1 10.1021/jm970389+
CHEMBL173642 66819 0 None - 1 Guinea pig 8.6 pKi = 8.6 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 538 4 0 6 5.6 Cc1nc2cnccc2n1CC1CCN(C(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)CC1 10.1021/jm970389+
10032022 17787 0 None - 1 Human 8.6 pKi = 8.6 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 635 16 0 11 4.6 CCCOc1c(OCCCN2CCOCC2)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CC(C)=O 10.1021/jm00097a005
CHEMBL117413 17787 0 None - 1 Human 8.6 pKi = 8.6 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 635 16 0 11 4.6 CCCOc1c(OCCCN2CCOCC2)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CC(C)=O 10.1021/jm00097a005
10430573 170115 0 None - 1 Guinea pig 8.6 pKi = 8.6 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 391 13 0 5 6.0 CCCCCCOc1c(OC)cc(CCCCc2scnc2C)cc1OC 10.1021/jm00012a012
CHEMBL419071 170115 0 None - 1 Guinea pig 8.6 pKi = 8.6 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 391 13 0 5 6.0 CCCCCCOc1c(OC)cc(CCCCc2scnc2C)cc1OC 10.1021/jm00012a012
44344325 121594 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 566 15 1 9 5.3 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)C[C@@H](C)CCCO 10.1021/jm00097a005
CHEMBL334115 121594 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 566 15 1 9 5.3 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)C[C@@H](C)CCCO 10.1021/jm00097a005
10744808 66707 0 None - 1 Guinea pig 8.5 pKi = 8.5 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 531 5 0 6 6.3 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(-c4ccc(F)cc4)c23)cc1 10.1021/jm970389+
CHEMBL173191 66707 0 None - 1 Guinea pig 8.5 pKi = 8.5 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 531 5 0 6 6.3 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(-c4ccc(F)cc4)c23)cc1 10.1021/jm970389+
10672429 138154 0 None - 1 Guinea pig 8.5 pKi = 8.5 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 482 6 1 8 4.1 COC(=O)c1ccc(C(=O)OC)c2c(C(=O)c3ccc(Cn4c(C)nc5cnccc54)cc3)c[nH]c12 10.1021/jm970389+
CHEMBL368923 138154 0 None - 1 Guinea pig 8.5 pKi = 8.5 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 482 6 1 8 4.1 COC(=O)c1ccc(C(=O)OC)c2c(C(=O)c3ccc(Cn4c(C)nc5cnccc54)cc3)c[nH]c12 10.1021/jm970389+
10767540 138905 0 None - 1 Guinea pig 8.5 pKi = 8.5 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 495 5 0 8 4.3 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4ncccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL369643 138905 0 None - 1 Guinea pig 8.5 pKi = 8.5 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 495 5 0 8 4.3 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4ncccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
197443 18419 5 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationIn vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparation
ChEMBL 566 15 1 10 4.2 CCCOc1c(OCCCO)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CC(C)=O 10.1021/jm00097a005
CHEMBL118105 18419 5 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationIn vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparation
ChEMBL 566 15 1 10 4.2 CCCOc1c(OCCCO)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CC(C)=O 10.1021/jm00097a005
44267844 17881 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 605 27 1 5 8.8 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccccc2)CSC1 10.1016/0960-894X(95)00173-Q
CHEMBL11696 17881 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 605 27 1 5 8.8 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccccc2)CSC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178030 17881 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 605 27 1 5 8.8 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccccc2)CSC1 10.1016/0960-894X(95)00173-Q
21463443 17886 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 618 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178039 17886 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 618 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL11872 17886 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 618 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL12352 17886 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 618 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
44268223 17901 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 563 22 0 5 7.9 CCCCCCCCCCCCCCCCOC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
CHEMBL1178072 17901 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 563 22 0 5 7.9 CCCCCCCCCCCCCCCCOC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
CHEMBL12499 17901 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 563 22 0 5 7.9 CCCCCCCCCCCCCCCCOC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
44330379 119143 0 None - 1 Guinea pig 6.7 pKi = 6.7 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 596 8 0 8 6.3 CN(C)CCO/N=C(\c1ccn2c1CS[C@@H]2c1cccnc1)c1cn(C(=O)N(C)C)c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00511-Q
CHEMBL329498 119143 0 None - 1 Guinea pig 6.7 pKi = 6.7 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 596 8 0 8 6.3 CN(C)CCO/N=C(\c1ccn2c1CS[C@@H]2c1cccnc1)c1cn(C(=O)N(C)C)c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00511-Q
44330428 118315 0 None - 1 Guinea pig 5.7 pKi = 5.7 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 526 4 1 6 6.3 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3C2=C[N+](=N)CC=C2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL327953 118315 0 None - 1 Guinea pig 5.7 pKi = 5.7 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 526 4 1 6 6.3 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3C2=C[N+](=N)CC=C2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
54761054 144859 0 None -1 2 Human 5.7 pKi = 5.7 Binding
Positive allosteric modulation of platelet-activating factor receptor (unknown origin)Positive allosteric modulation of platelet-activating factor receptor (unknown origin)
ChEMBL 367 3 1 5 4.0 Cc1ccc(C(C)(C)O)cc1-c1ccc2c(n1)n(C)c(=O)n2CC(C)(C)C 10.1016/j.bmcl.2016.01.021
CHEMBL3765778 144859 0 None -1 2 Human 5.7 pKi = 5.7 Binding
Positive allosteric modulation of platelet-activating factor receptor (unknown origin)Positive allosteric modulation of platelet-activating factor receptor (unknown origin)
ChEMBL 367 3 1 5 4.0 Cc1ccc(C(C)(C)O)cc1-c1ccc2c(n1)n(C)c(=O)n2CC(C)(C)C 10.1016/j.bmcl.2016.01.021
12800742 209630 0 None - 1 Guinea pig 4.7 pKi = 4.7 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 453 6 2 4 4.8 CC(CCCc1ccc(F)cc1)c1cc(O)c2c(c1)OC(C)(C)C1=C2CN(C(=O)CO)CC1 10.1021/jm00089a016
CHEMBL62503 209630 0 None - 1 Guinea pig 4.7 pKi = 4.7 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 453 6 2 4 4.8 CC(CCCc1ccc(F)cc1)c1cc(O)c2c(c1)OC(C)(C)C1=C2CN(C(=O)CO)CC1 10.1021/jm00089a016
14983481 210164 0 None - 1 Guinea pig 4.7 pKi = 4.7 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 494 9 2 4 5.8 CNC(=O)CCCN1CCC2=C(C1)c1c(O)cc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
CHEMBL65377 210164 0 None - 1 Guinea pig 4.7 pKi = 4.7 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 494 9 2 4 5.8 CNC(=O)CCCN1CCC2=C(C1)c1c(O)cc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
CHEMBL326215 117734 0 None - 1 Guinea pig 5.7 pKi = 5.7 Binding
Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor
ChEMBL 431 8 1 7 4.7 CC1=NC(C)=C(C(=O)OCCSc2ccccc2)C(C)/C1=C(\O)OCC1CCCO1 10.1021/jm00174a017
44268145 17905 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 547 22 0 5 7.1 CCCCCCCCCCCCCCCCOC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL1178081 17905 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 547 22 0 5 7.1 CCCCCCCCCCCCCCCCOC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL12708 17905 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 547 22 0 5 7.1 CCCCCCCCCCCCCCCCOC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
10099557 18083 0 None - 1 Guinea pig 5.7 pKi = 5.7 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 444 13 0 5 5.2 CCCCCCOc1c(OC)cc(C(=O)OCc2ccccc2C[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL1179276 18083 0 None - 1 Guinea pig 5.7 pKi = 5.7 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 444 13 0 5 5.2 CCCCCCOc1c(OC)cc(C(=O)OCc2ccccc2C[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL67396 18083 0 None - 1 Guinea pig 5.7 pKi = 5.7 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 444 13 0 5 5.2 CCCCCCOc1c(OC)cc(C(=O)OCc2ccccc2C[N+](C)(C)C)cc1OC 10.1021/jm00012a012
21463443 17886 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 618 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178039 17886 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 618 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL11872 17886 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 618 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL12352 17886 0 None - 1 Guinea pig 7.7 pKi = 7.7 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 618 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
44325242 113697 0 None - 1 Guinea pig 5.7 pKi = 5.7 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 458 5 1 5 3.8 CN1C(=O)N2[C@H](c3cccnc3)SC[C@H]2[C@H]1C(=O)Nc1cccc(C(=O)c2ccccc2)c1 10.1016/S0960-894X(01)80753-8
CHEMBL314744 113697 0 None - 1 Guinea pig 5.7 pKi = 5.7 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 458 5 1 5 3.8 CN1C(=O)N2[C@H](c3cccnc3)SC[C@H]2[C@H]1C(=O)Nc1cccc(C(=O)c2ccccc2)c1 10.1016/S0960-894X(01)80753-8
2812 11551 101 None -69 34 Human 4.6 pKi = 4.6 Binding
DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 11551 101 None -69 34 Human 4.6 pKi = 4.6 Binding
DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
9852175 84991 15 None -72443 3 Human 5.6 pKi = 5.6 Binding
Inhibition of platelet activating factor receptor (unknown origin)Inhibition of platelet activating factor receptor (unknown origin)
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
CHEMBL2105667 84991 15 None -72443 3 Human 5.6 pKi = 5.6 Binding
Inhibition of platelet activating factor receptor (unknown origin)Inhibition of platelet activating factor receptor (unknown origin)
ChEMBL 628 4 0 3 6.8 Cc1cc(F)ccc1[C@H]1C[C@@H](N2CCN3C(=O)CC[C@H]3C2)CCN1C(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmc.2013.09.001
10429945 170197 0 None - 1 Guinea pig 5.6 pKi = 5.6 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 381 14 0 6 4.2 CCCCCCOc1c(OC)cc(C(=O)OCCCCN(C)C)cc1OC 10.1021/jm00012a012
CHEMBL419620 170197 0 None - 1 Guinea pig 5.6 pKi = 5.6 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 381 14 0 6 4.2 CCCCCCOc1c(OC)cc(C(=O)OCCCCN(C)C)cc1OC 10.1021/jm00012a012
10815590 136222 0 None - 1 Guinea pig 7.6 pKi = 7.6 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 511 5 0 8 3.5 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4c[n+]([O-])ccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL367130 136222 0 None - 1 Guinea pig 7.6 pKi = 7.6 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 511 5 0 8 3.5 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4c[n+]([O-])ccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
14983499 210207 0 None - 1 Guinea pig 4.6 pKi = 4.6 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 484 9 4 5 4.3 CNC(=O)CN1CCC(C(C)(C)O)=C(c2c(O)cc(C(C)CCCc3ccc(F)cc3)cc2O)C1 10.1021/jm00089a016
CHEMBL65715 210207 0 None - 1 Guinea pig 4.6 pKi = 4.6 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 484 9 4 5 4.3 CNC(=O)CN1CCC(C(C)(C)O)=C(c2c(O)cc(C(C)CCCc3ccc(F)cc3)cc2O)C1 10.1021/jm00089a016
9870702 107057 13 None -1 2 Guinea pig 7.6 pKi = 7.6 Binding
Displacement of [3H]ligand from platelet activating factor (PAF) receptor in rabbit plateletsDisplacement of [3H]ligand from platelet activating factor (PAF) receptor in rabbit platelets
ChEMBL 502 6 0 5 7.7 Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)cc1 10.1016/0960-894X(95)00227-K
CHEMBL28902 107057 13 None -1 2 Guinea pig 7.6 pKi = 7.6 Binding
Displacement of [3H]ligand from platelet activating factor (PAF) receptor in rabbit plateletsDisplacement of [3H]ligand from platelet activating factor (PAF) receptor in rabbit platelets
ChEMBL 502 6 0 5 7.7 Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)cc1 10.1016/0960-894X(95)00227-K
44325472 112896 0 None - 1 Guinea pig 7.6 pKi = 7.6 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 445 5 1 6 3.9 O=C(c1ccccc1)c1cccc(NC(=O)[C@H]2OC(=O)N3[C@@H](c4cccnc4)SC[C@@H]23)c1 10.1016/S0960-894X(01)80753-8
CHEMBL313414 112896 0 None - 1 Guinea pig 7.6 pKi = 7.6 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 445 5 1 6 3.9 O=C(c1ccccc1)c1cccc(NC(=O)[C@H]2OC(=O)N3[C@@H](c4cccnc4)SC[C@@H]23)c1 10.1016/S0960-894X(01)80753-8
44330482 10965 0 None - 1 Guinea pig 6.6 pKi = 6.6 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 526 4 2 10 4.3 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3cnc(O)nc3O)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL100159 10965 0 None - 1 Guinea pig 6.6 pKi = 6.6 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 526 4 2 10 4.3 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3cnc(O)nc3O)cc21 10.1016/0960-894X(95)00511-Q
44370467 126627 0 None - 1 Guinea pig 5.6 pKi = 5.6 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 574 3 3 13 -0.0 C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](O)C34C(C(C)(C)C)[C@H]5OC(=O)OCc3ccccc3)[C@]21O 10.1021/jm0203985
CHEMBL348623 126627 0 None - 1 Guinea pig 5.6 pKi = 5.6 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 574 3 3 13 -0.0 C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](O)C34C(C(C)(C)C)[C@H]5OC(=O)OCc3ccccc3)[C@]21O 10.1021/jm0203985
10027153 18074 0 None - 1 Guinea pig 7.6 pKi = 7.6 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 422 14 0 6 4.6 CCCCCCOc1c(OC)cc(C(=O)OCCCC[n+]2ccsc2)cc1OC 10.1021/jm00012a012
CHEMBL1179250 18074 0 None - 1 Guinea pig 7.6 pKi = 7.6 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 422 14 0 6 4.6 CCCCCCOc1c(OC)cc(C(=O)OCCCC[n+]2ccsc2)cc1OC 10.1021/jm00012a012
CHEMBL66374 18074 0 None - 1 Guinea pig 7.6 pKi = 7.6 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 422 14 0 6 4.6 CCCCCCOc1c(OC)cc(C(=O)OCCCC[n+]2ccsc2)cc1OC 10.1021/jm00012a012
44330557 174640 0 None - 1 Guinea pig 6.6 pKi = 6.6 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 588 6 2 8 5.5 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(OP(=O)(O)O)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL431037 174640 0 None - 1 Guinea pig 6.6 pKi = 6.6 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 588 6 2 8 5.5 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(OP(=O)(O)O)cc3)cc21 10.1016/0960-894X(95)00511-Q
44325298 103259 0 None - 1 Guinea pig 5.6 pKi = 5.6 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 445 5 1 6 3.9 O=C(c1ccccc1)c1cccc(NC(=O)[C@@H]2OC(=O)N3[C@H](c4cccnc4)SC[C@@H]23)c1 10.1016/S0960-894X(01)80753-8
CHEMBL262427 103259 0 None - 1 Guinea pig 5.6 pKi = 5.6 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 445 5 1 6 3.9 O=C(c1ccccc1)c1cccc(NC(=O)[C@@H]2OC(=O)N3[C@H](c4cccnc4)SC[C@@H]23)c1 10.1016/S0960-894X(01)80753-8
14983502 107326 0 None - 1 Guinea pig 4.6 pKi = 4.6 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 523 12 1 4 7.2 COc1cc(C(C)CCCc2ccc(F)cc2)cc2c1C1=C(CCN(CCCCCC(=O)O)C1)C(C)(C)O2 10.1021/jm00089a016
CHEMBL291432 107326 0 None - 1 Guinea pig 4.6 pKi = 4.6 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 523 12 1 4 7.2 COc1cc(C(C)CCCc2ccc(F)cc2)cc2c1C1=C(CCN(CCCCCC(=O)O)C1)C(C)(C)O2 10.1021/jm00089a016
44268198 17906 0 None - 1 Guinea pig 7.6 pKi = 7.6 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 698 24 1 7 8.9 CCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(=O)c2ccc(OC)cc2)S1 10.1016/0960-894X(95)00174-R
CHEMBL1178083 17906 0 None - 1 Guinea pig 7.6 pKi = 7.6 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 698 24 1 7 8.9 CCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(=O)c2ccc(OC)cc2)S1 10.1016/0960-894X(95)00174-R
CHEMBL12773 17906 0 None - 1 Guinea pig 7.6 pKi = 7.6 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 698 24 1 7 8.9 CCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(=O)c2ccc(OC)cc2)S1 10.1016/0960-894X(95)00174-R
11800062 66717 0 None - 1 Guinea pig 6.6 pKi = 6.6 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 517 4 0 6 6.3 Cc1nc2cnccc2n1-c1ccc(C(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)cc1 10.1021/jm970389+
CHEMBL173215 66717 0 None - 1 Guinea pig 6.6 pKi = 6.6 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 517 4 0 6 6.3 Cc1nc2cnccc2n1-c1ccc(C(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)cc1 10.1021/jm970389+
10414574 18081 0 None - 1 Guinea pig 5.6 pKi = 5.6 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 400 13 0 4 5.0 CCCCCCOc1c(Cl)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL1179271 18081 0 None - 1 Guinea pig 5.6 pKi = 5.6 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 400 13 0 4 5.0 CCCCCCOc1c(Cl)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL67232 18081 0 None - 1 Guinea pig 5.6 pKi = 5.6 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 400 13 0 4 5.0 CCCCCCOc1c(Cl)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
10256234 18075 0 None - 1 Guinea pig 6.6 pKi = 6.6 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 396 14 0 5 4.3 CCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL1179252 18075 0 None - 1 Guinea pig 6.6 pKi = 6.6 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 396 14 0 5 4.3 CCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL66495 18075 0 None - 1 Guinea pig 6.6 pKi = 6.6 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 396 14 0 5 4.3 CCCCCCOc1c(OC)cc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
10485263 17889 0 None - 1 Guinea pig 6.6 pKi = 6.6 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 631 22 1 6 6.5 CCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CN(C(C)=O)C1 10.1016/0960-894X(95)00173-Q
CHEMBL1178045 17889 0 None - 1 Guinea pig 6.6 pKi = 6.6 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 631 22 1 6 6.5 CCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CN(C(C)=O)C1 10.1016/0960-894X(95)00173-Q
CHEMBL11989 17889 0 None - 1 Guinea pig 6.6 pKi = 6.6 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 631 22 1 6 6.5 CCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CN(C(C)=O)C1 10.1016/0960-894X(95)00173-Q
21463453 18743 0 None - 1 Guinea pig 7.6 pKi = 7.6 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 611 27 1 6 8.9 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccsc2)CSC1 10.1016/0960-894X(95)00173-Q
CHEMBL1182988 18743 0 None - 1 Guinea pig 7.6 pKi = 7.6 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 611 27 1 6 8.9 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccsc2)CSC1 10.1016/0960-894X(95)00173-Q
CHEMBL274843 18743 0 None - 1 Guinea pig 7.6 pKi = 7.6 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 611 27 1 6 8.9 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccsc2)CSC1 10.1016/0960-894X(95)00173-Q
44330596 115362 0 None - 1 Guinea pig 7.6 pKi = 7.6 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 565 4 0 7 5.9 CN1CCN(C(=O)n2cc(C(=O)c3ccn4c3CS[C@@H]4c3cccnc3)c3ccc(-c4ccc(F)cc4)cc32)CC1 10.1016/0960-894X(95)00511-Q
CHEMBL320371 115362 0 None - 1 Guinea pig 7.6 pKi = 7.6 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 565 4 0 7 5.9 CN1CCN(C(=O)n2cc(C(=O)c3ccn4c3CS[C@@H]4c3cccnc3)c3ccc(-c4ccc(F)cc4)cc32)CC1 10.1016/0960-894X(95)00511-Q
44278454 106660 0 None 2 2 Guinea pig 7.5 pKi = 7.5 Binding
Displacement of [3H]ligand from platelet activating factor (PAF) receptor in rabbit plateletsDisplacement of [3H]ligand from platelet activating factor (PAF) receptor in rabbit platelets
ChEMBL 468 6 0 5 7.0 Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3ccc4ccccc4n3)c2)cc1 10.1016/0960-894X(95)00227-K
CHEMBL28595 106660 0 None 2 2 Guinea pig 7.5 pKi = 7.5 Binding
Displacement of [3H]ligand from platelet activating factor (PAF) receptor in rabbit plateletsDisplacement of [3H]ligand from platelet activating factor (PAF) receptor in rabbit platelets
ChEMBL 468 6 0 5 7.0 Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3ccc4ccccc4n3)c2)cc1 10.1016/0960-894X(95)00227-K
10394043 163857 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 616 16 0 11 5.1 CCCOc1c(OCCCn2ccnc2)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CC(C)=O 10.1021/jm00097a005
CHEMBL407427 163857 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 616 16 0 11 5.1 CCCOc1c(OCCCn2ccnc2)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CC(C)=O 10.1021/jm00097a005
11799893 136509 0 None - 1 Guinea pig 8.5 pKi = 8.5 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 511 8 0 6 6.5 Cc1nc2cnccc2n1CCCCCC(=O)c1cn(C(=O)N(C)C)c2cccc(-c3ccc(F)cc3)c12 10.1021/jm970389+
CHEMBL367418 136509 0 None - 1 Guinea pig 8.5 pKi = 8.5 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 511 8 0 6 6.5 Cc1nc2cnccc2n1CCCCCC(=O)c1cn(C(=O)N(C)C)c2cccc(-c3ccc(F)cc3)c12 10.1021/jm970389+
131925 108549 17 None 2 2 Human 8.5 pKi = 8.5 Binding
Compound was tested for it''s ability to inhibit [3H]C18-PAF binding to PMN membrane receptorsCompound was tested for it''s ability to inhibit [3H]C18-PAF binding to PMN membrane receptors
ChEMBL 510 12 1 9 3.9 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO 10.1016/S0960-894X(01)80818-0
CHEMBL299944 108549 17 None 2 2 Human 8.5 pKi = 8.5 Binding
Compound was tested for it''s ability to inhibit [3H]C18-PAF binding to PMN membrane receptorsCompound was tested for it''s ability to inhibit [3H]C18-PAF binding to PMN membrane receptors
ChEMBL 510 12 1 9 3.9 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO 10.1016/S0960-894X(01)80818-0
131925 108549 17 None 2 2 Human 8.5 pKi = 8.5 Binding
In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationIn vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparation
ChEMBL 510 12 1 9 3.9 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO 10.1021/jm00097a005
CHEMBL299944 108549 17 None 2 2 Human 8.5 pKi = 8.5 Binding
In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationIn vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparation
ChEMBL 510 12 1 9 3.9 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO 10.1021/jm00097a005
44330570 114142 0 None - 1 Guinea pig 8.5 pKi = 8.5 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 546 7 1 7 5.0 NS(=O)(=O)CCn1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL317735 114142 0 None - 1 Guinea pig 8.5 pKi = 8.5 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 546 7 1 7 5.0 NS(=O)(=O)CCn1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
10625893 67126 0 None - 1 Guinea pig 8.5 pKi = 8.5 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 524 3 0 6 5.5 Cc1nc2cnccc2n1C1CCN(C(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)CC1 10.1021/jm970389+
CHEMBL174550 67126 0 None - 1 Guinea pig 8.5 pKi = 8.5 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 524 3 0 6 5.5 Cc1nc2cnccc2n1C1CCN(C(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)CC1 10.1021/jm970389+
11800214 67019 0 None - 1 Guinea pig 8.4 pKi = 8.4 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 524 5 0 8 4.6 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(OC(=O)N(C)C)c23)cc1 10.1021/jm970389+
CHEMBL174104 67019 0 None - 1 Guinea pig 8.4 pKi = 8.4 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 524 5 0 8 4.6 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(OC(=O)N(C)C)c23)cc1 10.1021/jm970389+
44344325 121594 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationIn vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparation
ChEMBL 566 15 1 9 5.3 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)C[C@@H](C)CCCO 10.1021/jm00097a005
CHEMBL334115 121594 0 None - 1 Human 8.4 pKi = 8.4 Binding
In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationIn vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparation
ChEMBL 566 15 1 9 5.3 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)C[C@@H](C)CCCO 10.1021/jm00097a005
44344131 17004 0 None - 1 Human 8.4 pKi = 8.4 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 566 15 1 9 5.3 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)C[C@H](C)CCCO 10.1021/jm00097a005
CHEMBL116072 17004 0 None - 1 Human 8.4 pKi = 8.4 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 566 15 1 9 5.3 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)C[C@H](C)CCCO 10.1021/jm00097a005
9957997 214950 25 None -1 2 Guinea pig 8.4 pKi = 8.4 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 510 4 0 6 6.2 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL98318 214950 25 None -1 2 Guinea pig 8.4 pKi = 8.4 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 510 4 0 6 6.2 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
9957997 214950 25 None 1 2 Rat 8.4 pKi = 8.4 Binding
Inhibition of platelet activating factor (PAF) by binding to PAF receptorInhibition of platelet activating factor (PAF) by binding to PAF receptor
ChEMBL 510 4 0 6 6.2 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00510-Z
CHEMBL98318 214950 25 None 1 2 Rat 8.4 pKi = 8.4 Binding
Inhibition of platelet activating factor (PAF) by binding to PAF receptorInhibition of platelet activating factor (PAF) by binding to PAF receptor
ChEMBL 510 4 0 6 6.2 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00510-Z
1849 7018 3 None -6 2 Guinea pig 8.4 pKi = 8.4 Binding
The compound was evaluated for its binding affinity against PAF receptor in rabbit plateletThe compound was evaluated for its binding affinity against PAF receptor in rabbit platelet
ChEMBL 618 6 0 7 2.6 CC(=O)OC[n+]1cccc(c1)[C@H]1SCc2n1ccc2C(=O)c1cn(c2c1ccc(c2)c1ccc(cc1)F)C(=O)N(C)C.[Cl-] 10.1021/jm970389+
9830503 7018 3 None -6 2 Guinea pig 8.4 pKi = 8.4 Binding
The compound was evaluated for its binding affinity against PAF receptor in rabbit plateletThe compound was evaluated for its binding affinity against PAF receptor in rabbit platelet
ChEMBL 618 6 0 7 2.6 CC(=O)OC[n+]1cccc(c1)[C@H]1SCc2n1ccc2C(=O)c1cn(c2c1ccc(c2)c1ccc(cc1)F)C(=O)N(C)C.[Cl-] 10.1021/jm970389+
CHEMBL1183764 7018 3 None -6 2 Guinea pig 8.4 pKi = 8.4 Binding
The compound was evaluated for its binding affinity against PAF receptor in rabbit plateletThe compound was evaluated for its binding affinity against PAF receptor in rabbit platelet
ChEMBL 618 6 0 7 2.6 CC(=O)OC[n+]1cccc(c1)[C@H]1SCc2n1ccc2C(=O)c1cn(c2c1ccc(c2)c1ccc(cc1)F)C(=O)N(C)C.[Cl-] 10.1021/jm970389+
CHEMBL317090 7018 3 None -6 2 Guinea pig 8.4 pKi = 8.4 Binding
The compound was evaluated for its binding affinity against PAF receptor in rabbit plateletThe compound was evaluated for its binding affinity against PAF receptor in rabbit platelet
ChEMBL 618 6 0 7 2.6 CC(=O)OC[n+]1cccc(c1)[C@H]1SCc2n1ccc2C(=O)c1cn(c2c1ccc(c2)c1ccc(cc1)F)C(=O)N(C)C.[Cl-] 10.1021/jm970389+
44267830 17893 0 None - 1 Guinea pig 7.5 pKi = 7.5 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 655 27 1 5 10.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2cccc3ccccc32)CSC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178052 17893 0 None - 1 Guinea pig 7.5 pKi = 7.5 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 655 27 1 5 10.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2cccc3ccccc32)CSC1 10.1016/0960-894X(95)00173-Q
CHEMBL12125 17893 0 None - 1 Guinea pig 7.5 pKi = 7.5 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 655 27 1 5 10.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2cccc3ccccc32)CSC1 10.1016/0960-894X(95)00173-Q
21463457 17887 0 None - 1 Guinea pig 7.5 pKi = 7.5 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 595 27 1 6 8.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccsc2)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178043 17887 0 None - 1 Guinea pig 7.5 pKi = 7.5 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 595 27 1 6 8.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccsc2)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL11962 17887 0 None - 1 Guinea pig 7.5 pKi = 7.5 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 595 27 1 6 8.1 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCCC[n+]2ccsc2)COC1 10.1016/0960-894X(95)00173-Q
44330583 21429 0 None - 1 Guinea pig 6.5 pKi = 6.5 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 623 6 1 8 6.6 O=C(c1ccn2c1CS[C@@H]2c1cccnc1)c1cn(C(=O)c2ccccc2S(=O)(=O)O)c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00511-Q
CHEMBL100201 21429 0 None - 1 Guinea pig 6.5 pKi = 6.5 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 623 6 1 8 6.6 O=C(c1ccn2c1CS[C@@H]2c1cccnc1)c1cn(C(=O)c2ccccc2S(=O)(=O)O)c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00511-Q
CHEMBL1205458 21429 0 None - 1 Guinea pig 6.5 pKi = 6.5 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 623 6 1 8 6.6 O=C(c1ccn2c1CS[C@@H]2c1cccnc1)c1cn(C(=O)c2ccccc2S(=O)(=O)O)c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00511-Q
10697758 67137 0 None - 1 Guinea pig 7.5 pKi = 7.5 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 542 5 0 8 4.7 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(OC(=O)N(C)C)c23)cc1F 10.1021/jm970389+
CHEMBL174618 67137 0 None - 1 Guinea pig 7.5 pKi = 7.5 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 542 5 0 8 4.7 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(OC(=O)N(C)C)c23)cc1F 10.1021/jm970389+
3085018 109056 15 None - 1 Guinea pig 5.5 pKi = 5.5 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 433 6 1 3 5.9 C#CCN1CCC2=C(C1)c1c(O)cc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
CHEMBL303312 109056 15 None - 1 Guinea pig 5.5 pKi = 5.5 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 433 6 1 3 5.9 C#CCN1CCC2=C(C1)c1c(O)cc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
10074948 18086 0 None - 1 Guinea pig 7.5 pKi = 7.5 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 380 15 0 3 5.5 CCCCCCOc1c(OC)cc(CCCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL1179303 18086 0 None - 1 Guinea pig 7.5 pKi = 7.5 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 380 15 0 3 5.5 CCCCCCOc1c(OC)cc(CCCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL68653 18086 0 None - 1 Guinea pig 7.5 pKi = 7.5 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 380 15 0 3 5.5 CCCCCCOc1c(OC)cc(CCCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
14983495 209063 0 None - 1 Guinea pig 5.5 pKi = 5.5 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 468 7 2 4 5.0 CNC(=O)CN1CCC2C(C1)c1c(O)cc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
CHEMBL61014 209063 0 None - 1 Guinea pig 5.5 pKi = 5.5 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 468 7 2 4 5.0 CNC(=O)CN1CCC2C(C1)c1c(O)cc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
14983494 209766 0 None - 1 Guinea pig 6.5 pKi = 6.5 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 466 7 2 4 5.0 CNC(=O)CN1CCC2=C(C1)c1c(O)cc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
CHEMBL63111 209766 0 None - 1 Guinea pig 6.5 pKi = 6.5 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 466 7 2 4 5.0 CNC(=O)CN1CCC2=C(C1)c1c(O)cc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
44268136 17903 0 None - 1 Guinea pig 7.5 pKi = 7.5 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 726 26 1 7 9.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(=O)c2ccc(OC)cc2)S1 10.1016/0960-894X(95)00174-R
CHEMBL1178074 17903 0 None - 1 Guinea pig 7.5 pKi = 7.5 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 726 26 1 7 9.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(=O)c2ccc(OC)cc2)S1 10.1016/0960-894X(95)00174-R
CHEMBL12556 17903 0 None - 1 Guinea pig 7.5 pKi = 7.5 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 726 26 1 7 9.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(=O)c2ccc(OC)cc2)S1 10.1016/0960-894X(95)00174-R
44305014 210309 0 None - 1 Guinea pig 6.5 pKi = 6.5 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 450 7 1 3 5.3 CNC(=O)CN1CCC2=C(C1)c1ccc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
CHEMBL66414 210309 0 None - 1 Guinea pig 6.5 pKi = 6.5 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 450 7 1 3 5.3 CNC(=O)CN1CCC2=C(C1)c1ccc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
9987194 17904 0 None - 1 Guinea pig 7.5 pKi = 7.5 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 659 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)N1C(C)=O 10.1016/0960-894X(95)00174-R
CHEMBL1178075 17904 0 None - 1 Guinea pig 7.5 pKi = 7.5 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 659 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)N1C(C)=O 10.1016/0960-894X(95)00174-R
CHEMBL12558 17904 0 None - 1 Guinea pig 7.5 pKi = 7.5 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 659 24 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)N1C(C)=O 10.1016/0960-894X(95)00174-R
21321139 109427 0 None - 1 Guinea pig 5.4 pKi = 5.4 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 428 8 2 4 5.1 CCCCCC(C)C(C)c1cc(O)c2c(c1)OC(C)(C)C1=C2CN(CC(=O)NC)CC1 10.1021/jm00089a016
CHEMBL304427 109427 0 None - 1 Guinea pig 5.4 pKi = 5.4 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 428 8 2 4 5.1 CCCCCC(C)C(C)c1cc(O)c2c(c1)OC(C)(C)C1=C2CN(CC(=O)NC)CC1 10.1021/jm00089a016
9848518 114067 5 None -1 2 Guinea pig 7.4 pKi = 7.4 Binding
Displacement of [3H]ligand from platelet activating factor (PAF) receptor in rabbit plateletsDisplacement of [3H]ligand from platelet activating factor (PAF) receptor in rabbit platelets
ChEMBL 492 6 0 6 7.2 Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3nc4cc(F)ccc4s3)c2)cc1 10.1016/0960-894X(95)00227-K
CHEMBL31714 114067 5 None -1 2 Guinea pig 7.4 pKi = 7.4 Binding
Displacement of [3H]ligand from platelet activating factor (PAF) receptor in rabbit plateletsDisplacement of [3H]ligand from platelet activating factor (PAF) receptor in rabbit platelets
ChEMBL 492 6 0 6 7.2 Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3nc4cc(F)ccc4s3)c2)cc1 10.1016/0960-894X(95)00227-K
44330572 118433 0 None - 1 Guinea pig 7.4 pKi = 7.4 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 482 6 1 6 5.6 NCCn1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL328632 118433 0 None - 1 Guinea pig 7.4 pKi = 7.4 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 482 6 1 6 5.6 NCCn1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
44330497 115132 0 None - 1 Guinea pig 7.4 pKi = 7.4 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 482 4 0 7 5.7 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccco3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL319811 115132 0 None - 1 Guinea pig 7.4 pKi = 7.4 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 482 4 0 7 5.7 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccco3)cc21 10.1016/0960-894X(95)00511-Q
10840116 66742 0 None - 1 Guinea pig 7.4 pKi = 7.4 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 538 5 0 8 5.8 Cc1nc2cnccc2n1Cc1csc(C(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)n1 10.1021/jm970389+
CHEMBL173318 66742 0 None - 1 Guinea pig 7.4 pKi = 7.4 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 538 5 0 8 5.8 Cc1nc2cnccc2n1Cc1csc(C(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)n1 10.1021/jm970389+
10650366 105251 0 None - 1 Guinea pig 7.4 pKi = 7.4 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 553 5 0 7 4.5 Cc1nc2cnccc2n1CCN1CCN(C(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)CC1 10.1021/jm970389+
CHEMBL275912 105251 0 None - 1 Guinea pig 7.4 pKi = 7.4 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 553 5 0 7 4.5 Cc1nc2cnccc2n1CCN1CCN(C(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)CC1 10.1021/jm970389+
132299 209697 7 None - 1 Guinea pig 6.4 pKi = 6.4 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 552 11 1 6 5.3 CCOC(=O)COc1cc(C(C)CCCc2ccc(F)cc2)cc2c1C1=C(CCN(CC(=O)NC)C1)C(C)(C)O2 10.1021/jm00089a016
CHEMBL62812 209697 7 None - 1 Guinea pig 6.4 pKi = 6.4 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 552 11 1 6 5.3 CCOC(=O)COc1cc(C(C)CCCc2ccc(F)cc2)cc2c1C1=C(CCN(CC(=O)NC)C1)C(C)(C)O2 10.1021/jm00089a016
10815591 66040 0 None - 1 Guinea pig 8.4 pKi = 8.4 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 511 5 1 9 4.0 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4c(O)nccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL170398 66040 0 None - 1 Guinea pig 8.4 pKi = 8.4 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 511 5 1 9 4.0 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4c(O)nccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
21463423 19197 0 None - 1 Guinea pig 8.4 pKi = 8.4 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 630 24 1 5 9.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL1185897 19197 0 None - 1 Guinea pig 8.4 pKi = 8.4 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 630 24 1 5 9.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL440088 19197 0 None - 1 Guinea pig 8.4 pKi = 8.4 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 630 24 1 5 9.0 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCC1 10.1016/0960-894X(95)00173-Q
10839974 137395 0 None - 1 Guinea pig 8.4 pKi = 8.4 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 531 7 0 9 3.4 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2S(=O)(=O)N(C)C 10.1021/jm970389+
CHEMBL368162 137395 0 None - 1 Guinea pig 8.4 pKi = 8.4 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 531 7 0 9 3.4 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2S(=O)(=O)N(C)C 10.1021/jm970389+
44268181 17898 0 None - 1 Guinea pig 8.4 pKi = 8.4 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 634 24 1 6 8.3 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
CHEMBL1178062 17898 0 None - 1 Guinea pig 8.4 pKi = 8.4 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 634 24 1 6 8.3 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
CHEMBL12399 17898 0 None - 1 Guinea pig 8.4 pKi = 8.4 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 634 24 1 6 8.3 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
10327687 17899 0 None - 1 Guinea pig 8.4 pKi = 8.4 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 616 24 1 5 8.5 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1016/0960-894X(95)00174-R
CHEMBL1178067 17899 0 None - 1 Guinea pig 8.4 pKi = 8.4 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 616 24 1 5 8.5 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1016/0960-894X(95)00174-R
CHEMBL12438 17899 0 None - 1 Guinea pig 8.4 pKi = 8.4 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 616 24 1 5 8.5 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)C1 10.1016/0960-894X(95)00174-R
10601750 138884 0 None - 1 Guinea pig 8.4 pKi = 8.4 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 509 7 0 8 3.8 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2CC(=O)N(C)C 10.1021/jm970389+
CHEMBL369578 138884 0 None - 1 Guinea pig 8.4 pKi = 8.4 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 509 7 0 8 3.8 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2CC(=O)N(C)C 10.1021/jm970389+
10720833 66700 0 None - 1 Guinea pig 8.3 pKi = 8.3 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 523 6 0 8 5.1 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(C(=O)OC(C)C)c23)cc1 10.1021/jm970389+
CHEMBL173157 66700 0 None - 1 Guinea pig 8.3 pKi = 8.3 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 523 6 0 8 5.1 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(C(=O)OC(C)C)c23)cc1 10.1021/jm970389+
44330216 18147 0 None - 1 Guinea pig 5.4 pKi = 5.4 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 526 4 0 6 6.1 CN1C=C([C@H]2SCc3c(C(=O)c4cn(C(=O)N(C)C)c5cc(-c6ccc(F)cc6)ccc45)ccn32)C=CC1 10.1016/0960-894X(95)00511-Q
CHEMBL1179776 18147 0 None - 1 Guinea pig 5.4 pKi = 5.4 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 526 4 0 6 6.1 CN1C=C([C@H]2SCc3c(C(=O)c4cn(C(=O)N(C)C)c5cc(-c6ccc(F)cc6)ccc45)ccn32)C=CC1 10.1016/0960-894X(95)00511-Q
CHEMBL99395 18147 0 None - 1 Guinea pig 5.4 pKi = 5.4 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 526 4 0 6 6.1 CN1C=C([C@H]2SCc3c(C(=O)c4cn(C(=O)N(C)C)c5cc(-c6ccc(F)cc6)ccc45)ccn32)C=CC1 10.1016/0960-894X(95)00511-Q
10341362 210490 0 None - 1 Guinea pig 7.4 pKi = 7.4 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 407 12 0 7 4.8 CCCCCCOc1c(OC)cc(C(=O)OCCc2scnc2C)cc1OC 10.1021/jm00012a012
CHEMBL67618 210490 0 None - 1 Guinea pig 7.4 pKi = 7.4 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 407 12 0 7 4.8 CCCCCCOc1c(OC)cc(C(=O)OCCc2scnc2C)cc1OC 10.1021/jm00012a012
14983487 210186 0 None - 1 Guinea pig 5.4 pKi = 5.4 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 500 8 0 4 7.2 COc1cc(C(C)CCCc2ccc(F)cc2)cc2c1C1=C(CCN(Cc3ccccn3)C1)C(C)(C)O2 10.1021/jm00089a016
CHEMBL65556 210186 0 None - 1 Guinea pig 5.4 pKi = 5.4 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 500 8 0 4 7.2 COc1cc(C(C)CCCc2ccc(F)cc2)cc2c1C1=C(CCN(Cc3ccccn3)C1)C(C)(C)O2 10.1021/jm00089a016
118718615 122148 0 None - 1 Guinea pig 5.4 pKi = 5.4 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 440 0 4 11 -2.4 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@]34[C@@H]5OC(=O)[C@]3(OC3OC(=O)[C@H](O)C34[C@H](C(C)(C)C)[C@H]5O)[C@@]12O 10.1021/jm0203985
CHEMBL3349895 122148 0 None - 1 Guinea pig 5.4 pKi = 5.4 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 440 0 4 11 -2.4 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@]34[C@@H]5OC(=O)[C@]3(OC3OC(=O)[C@H](O)C34[C@H](C(C)(C)C)[C@H]5O)[C@@]12O 10.1021/jm0203985
3044918 209471 2 None - 1 Guinea pig 4.4 pKi = 4.4 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 412 5 1 3 6.9 CC1CSC2=C1c1c(O)cc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
CHEMBL61627 209471 2 None - 1 Guinea pig 4.4 pKi = 4.4 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 412 5 1 3 6.9 CC1CSC2=C1c1c(O)cc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
14983492 209659 0 None - 1 Guinea pig 5.4 pKi = 5.4 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 481 9 1 4 6.1 COc1cc(C(C)CCCc2ccc(F)cc2)cc2c1C1=C(CCN(CCC(=O)O)C1)C(C)(C)O2 10.1021/jm00089a016
CHEMBL62650 209659 0 None - 1 Guinea pig 5.4 pKi = 5.4 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 481 9 1 4 6.1 COc1cc(C(C)CCCc2ccc(F)cc2)cc2c1C1=C(CCN(CCC(=O)O)C1)C(C)(C)O2 10.1021/jm00089a016
CHEMBL109083 14804 0 None - 1 Guinea pig 5.4 pKi = 5.4 Binding
Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor
ChEMBL 343 8 1 7 2.7 COCCO/C(O)=C1\C(C)=NC(C)=C(C(=O)OCCSC)C1C 10.1021/jm00174a017
44330538 114057 0 None - 1 Guinea pig 7.4 pKi = 7.4 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 571 5 1 8 4.7 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(S(N)(=O)=O)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL317069 114057 0 None - 1 Guinea pig 7.4 pKi = 7.4 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 571 5 1 8 4.7 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(S(N)(=O)=O)cc3)cc21 10.1016/0960-894X(95)00511-Q
44330474 113956 0 None - 1 Guinea pig 6.4 pKi = 6.4 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 636 9 0 8 7.2 CN(C)C(=O)n1cc(/C(=N/OCCCN2CCCC2)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL316463 113956 0 None - 1 Guinea pig 6.4 pKi = 6.4 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 636 9 0 8 7.2 CN(C)C(=O)n1cc(/C(=N/OCCCN2CCCC2)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
10074418 18079 0 None - 1 Guinea pig 5.3 pKi = 5.3 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 366 13 0 4 4.3 CCCCCCOc1ccc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL1179267 18079 0 None - 1 Guinea pig 5.3 pKi = 5.3 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 366 13 0 4 4.3 CCCCCCOc1ccc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
CHEMBL67016 18079 0 None - 1 Guinea pig 5.3 pKi = 5.3 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 366 13 0 4 4.3 CCCCCCOc1ccc(C(=O)OCCCC[N+](C)(C)C)cc1OC 10.1021/jm00012a012
44353072 122310 0 None - 1 Mouse 6.3 pKi = 6.3 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 638 4 3 13 1.0 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@]34C5OC(=O)C3(OC3OC(=O)[C@H](OCc6ccc(C7(C(F)(F)F)N=N7)cc6)C34[C@H](C(C)(C)C)[C@H]5O)[C@@]12O 10.1021/jm020147w
CHEMBL335310 122310 0 None - 1 Mouse 6.3 pKi = 6.3 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 638 4 3 13 1.0 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@]34C5OC(=O)C3(OC3OC(=O)[C@H](OCc6ccc(C7(C(F)(F)F)N=N7)cc6)C34[C@H](C(C)(C)C)[C@H]5O)[C@@]12O 10.1021/jm020147w
10619764 127102 0 None - 1 Guinea pig 7.3 pKi = 7.3 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 380 4 1 4 4.8 Cc1[nH]c2ccccc2c1C(=O)c1ccc(Cn2c(C)nc3cnccc32)cc1 10.1021/jm970389+
CHEMBL352872 127102 0 None - 1 Guinea pig 7.3 pKi = 7.3 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 380 4 1 4 4.8 Cc1[nH]c2ccccc2c1C(=O)c1ccc(Cn2c(C)nc3cnccc32)cc1 10.1021/jm970389+
10459422 18826 0 None - 1 Guinea pig 6.3 pKi = 6.3 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 396 14 0 5 4.3 CCCCCCOc1cc(C(=O)OCCCC[N+](C)(C)C)cc(OC)c1OC 10.1021/jm00012a012
CHEMBL1183541 18826 0 None - 1 Guinea pig 6.3 pKi = 6.3 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 396 14 0 5 4.3 CCCCCCOc1cc(C(=O)OCCCC[N+](C)(C)C)cc(OC)c1OC 10.1021/jm00012a012
CHEMBL303480 18826 0 None - 1 Guinea pig 6.3 pKi = 6.3 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 396 14 0 5 4.3 CCCCCCOc1cc(C(=O)OCCCC[N+](C)(C)C)cc(OC)c1OC 10.1021/jm00012a012
10625598 136453 0 None - 1 Guinea pig 8.3 pKi = 8.3 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 513 5 0 8 4.4 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)c(F)c1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL367393 136453 0 None - 1 Guinea pig 8.3 pKi = 8.3 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 513 5 0 8 4.4 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)c(F)c1)cn2C(=O)N(C)C 10.1021/jm970389+
129796 107232 39 None - 1 Guinea pig 8.3 pKi = 8.3 Binding
Displacement of [3H]ligand from platelet activating factor (PAF) receptor in rabbit plateletsDisplacement of [3H]ligand from platelet activating factor (PAF) receptor in rabbit platelets
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1016/0960-894X(95)00227-K
CHEMBL29067 107232 39 None - 1 Guinea pig 8.3 pKi = 8.3 Binding
Displacement of [3H]ligand from platelet activating factor (PAF) receptor in rabbit plateletsDisplacement of [3H]ligand from platelet activating factor (PAF) receptor in rabbit platelets
ChEMBL 604 7 2 8 6.4 CCOC(=O)C1=C(c2ccc(-n3c(C)nc4cnccc43)cc2)NC(C)=C(C(=O)Nc2ccccn2)C1c1ccccc1Cl 10.1016/0960-894X(95)00227-K
9865147 109063 0 None - 1 Guinea pig 8.3 pKi = 8.3 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 389 5 2 5 3.7 O=C(c1ccccc1)c1cccc(NC(=O)[C@@H]2CSC(c3cccnc3)N2)c1 10.1016/S0960-894X(01)80753-8
CHEMBL303357 109063 0 None - 1 Guinea pig 8.3 pKi = 8.3 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 389 5 2 5 3.7 O=C(c1ccccc1)c1cccc(NC(=O)[C@@H]2CSC(c3cccnc3)N2)c1 10.1016/S0960-894X(01)80753-8
10551723 136304 0 None - 1 Guinea pig 8.3 pKi = 8.3 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 455 4 0 6 4.6 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(F)c23)cc1 10.1021/jm970389+
CHEMBL367295 136304 0 None - 1 Guinea pig 8.3 pKi = 8.3 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 455 4 0 6 4.6 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(F)c23)cc1 10.1021/jm970389+
10625500 67116 0 None - 1 Guinea pig 8.3 pKi = 8.3 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 509 6 0 8 4.7 CCOC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL174479 67116 0 None - 1 Guinea pig 8.3 pKi = 8.3 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 509 6 0 8 4.7 CCOC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)cc1)cn2C(=O)N(C)C 10.1021/jm970389+
44344131 17004 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationIn vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparation
ChEMBL 566 15 1 9 5.3 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)C[C@H](C)CCCO 10.1021/jm00097a005
CHEMBL116072 17004 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationIn vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparation
ChEMBL 566 15 1 9 5.3 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)C[C@H](C)CCCO 10.1021/jm00097a005
10576375 66576 0 None - 1 Guinea pig 8.3 pKi = 8.3 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 471 4 0 6 5.2 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(Cl)c23)cc1 10.1021/jm970389+
CHEMBL172697 66576 0 None - 1 Guinea pig 8.3 pKi = 8.3 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 471 4 0 6 5.2 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(Cl)c23)cc1 10.1021/jm970389+
9987603 17902 0 None - 1 Guinea pig 8.2 pKi = 8.2 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL1178073 17902 0 None - 1 Guinea pig 8.2 pKi = 8.2 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL12554 17902 0 None - 1 Guinea pig 8.2 pKi = 8.2 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL321486 115960 0 None - 1 Guinea pig 6.3 pKi = 6.3 Binding
Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor
ChEMBL 313 6 1 6 3.1 CCSCCO/C(O)=C1\C(C)=NC(C)=C(C(=O)OC)C1C 10.1021/jm00174a017
10718881 138618 0 None - 1 Guinea pig 7.3 pKi = 7.3 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 462 4 0 7 4.4 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(C#N)c23)cc1 10.1021/jm970389+
CHEMBL369411 138618 0 None - 1 Guinea pig 7.3 pKi = 7.3 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 462 4 0 7 4.4 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(C#N)c23)cc1 10.1021/jm970389+
21463406 19139 0 None - 1 Guinea pig 7.3 pKi = 7.3 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 524 25 0 5 7.7 CCCCCCCCCCCCCCCCOCC1(COC(=O)CCCCC[n+]2ccsc2)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL1185494 19139 0 None - 1 Guinea pig 7.3 pKi = 7.3 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 524 25 0 5 7.7 CCCCCCCCCCCCCCCCOCC1(COC(=O)CCCCC[n+]2ccsc2)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL417432 19139 0 None - 1 Guinea pig 7.3 pKi = 7.3 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 524 25 0 5 7.7 CCCCCCCCCCCCCCCCOCC1(COC(=O)CCCCC[n+]2ccsc2)COC1 10.1016/0960-894X(95)00173-Q
44330447 21570 0 None - 1 Guinea pig 7.3 pKi = 7.3 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 709 7 1 10 6.8 CN(C)C(=O)n1cc(/C(=N/OC(=O)c2ccc(S(=O)(=O)O)cc2)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL1206856 21570 0 None - 1 Guinea pig 7.3 pKi = 7.3 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 709 7 1 10 6.8 CN(C)C(=O)n1cc(/C(=N/OC(=O)c2ccc(S(=O)(=O)O)cc2)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL318009 21570 0 None - 1 Guinea pig 7.3 pKi = 7.3 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 709 7 1 10 6.8 CN(C)C(=O)n1cc(/C(=N/OC(=O)c2ccc(S(=O)(=O)O)cc2)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
10555384 30049 0 None - 1 Guinea pig 7.3 pKi = 7.3 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 589 6 0 8 4.0 Cc1nc2cnccc2n1CCN1CCN(S(=O)(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)CC1 10.1021/jm970389+
CHEMBL133197 30049 0 None - 1 Guinea pig 7.3 pKi = 7.3 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 589 6 0 8 4.0 Cc1nc2cnccc2n1CCN1CCN(S(=O)(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)CC1 10.1021/jm970389+
44330537 119382 0 None - 1 Guinea pig 7.3 pKi = 7.3 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 579 7 2 8 5.0 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(C[C@H](N)C(=O)O)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL330219 119382 0 None - 1 Guinea pig 7.3 pKi = 7.3 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 579 7 2 8 5.0 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(C[C@H](N)C(=O)O)cc3)cc21 10.1016/0960-894X(95)00511-Q
44325254 214163 0 None - 1 Guinea pig 6.3 pKi = 6.3 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 443 5 1 5 3.9 O=C(c1ccccc1)c1cccc(NC(=O)[C@H]2CC(=O)N3[C@@H](c4cccnc4)SC[C@@H]23)c1 10.1016/S0960-894X(01)80753-8
CHEMBL93807 214163 0 None - 1 Guinea pig 6.3 pKi = 6.3 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 443 5 1 5 3.9 O=C(c1ccccc1)c1cccc(NC(=O)[C@H]2CC(=O)N3[C@@H](c4cccnc4)SC[C@@H]23)c1 10.1016/S0960-894X(01)80753-8
44370480 54162 0 None - 1 Guinea pig 6.3 pKi = 6.3 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 465 1 3 11 -1.1 C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](O)C34C(C(C)(C)C)[C@H]5N=[N+]=[N-])[C@]21O 10.1021/jm0203985
CHEMBL154481 54162 0 None - 1 Guinea pig 6.3 pKi = 6.3 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 465 1 3 11 -1.1 C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](O)C34C(C(C)(C)C)[C@H]5N=[N+]=[N-])[C@]21O 10.1021/jm0203985
14983493 209482 0 None - 1 Guinea pig 5.3 pKi = 5.3 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 494 9 1 4 5.7 CNC(=O)CCN1CCC2=C(C1)c1c(OC)cc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
CHEMBL61678 209482 0 None - 1 Guinea pig 5.3 pKi = 5.3 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 494 9 1 4 5.7 CNC(=O)CCN1CCC2=C(C1)c1c(OC)cc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
14983501 210146 0 None - 1 Guinea pig 5.3 pKi = 5.3 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 509 11 1 4 6.8 COc1cc(C(C)CCCc2ccc(F)cc2)cc2c1C1=C(CCN(CCCCC(=O)O)C1)C(C)(C)O2 10.1021/jm00089a016
CHEMBL65199 210146 0 None - 1 Guinea pig 5.3 pKi = 5.3 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 509 11 1 4 6.8 COc1cc(C(C)CCCc2ccc(F)cc2)cc2c1C1=C(CCN(CCCCC(=O)O)C1)C(C)(C)O2 10.1021/jm00089a016
21463436 17897 0 None - 1 Guinea pig 7.3 pKi = 7.3 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 645 24 1 5 9.4 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178061 17897 0 None - 1 Guinea pig 7.3 pKi = 7.3 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 645 24 1 5 9.4 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL12382 17897 0 None - 1 Guinea pig 7.3 pKi = 7.3 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 645 24 1 5 9.4 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCCCC1 10.1016/0960-894X(95)00173-Q
44353151 123777 0 None - 1 Mouse 6.3 pKi = 6.3 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 440 1 3 10 -0.9 COC1OC(=O)[C@H](O)C12[C@H](C(C)(C)C)CC1OC(=O)C3[C@@]4(O)[C@H](C)C(=O)O[C@H]4[C@H](O)[C@]132 10.1021/jm020147w
CHEMBL338808 123777 0 None - 1 Mouse 6.3 pKi = 6.3 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 440 1 3 10 -0.9 COC1OC(=O)[C@H](O)C12[C@H](C(C)(C)C)CC1OC(=O)C3[C@@]4(O)[C@H](C)C(=O)O[C@H]4[C@H](O)[C@]132 10.1021/jm020147w
44353099 123579 0 None - 1 Mouse 6.2 pKi = 6.2 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 634 5 3 12 1.1 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@]34C5OC(=O)C3(OC3OC(=O)[C@H](OCc6ccc(C(=O)c7ccccc7)cc6)C34[C@H](C(C)(C)C)[C@H]5O)[C@@]12O 10.1021/jm020147w
CHEMBL337840 123579 0 None - 1 Mouse 6.2 pKi = 6.2 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 634 5 3 12 1.1 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@]34C5OC(=O)C3(OC3OC(=O)[C@H](OCc6ccc(C(=O)c7ccccc7)cc6)C34[C@H](C(C)(C)C)[C@H]5O)[C@@]12O 10.1021/jm020147w
18755202 15646 5 None - 1 Human 7.2 pKi = 7.2 Binding
Compound was tested for it''s ability to inhibit [3H]C18-PAF binding to PMN membrane receptorsCompound was tested for it''s ability to inhibit [3H]C18-PAF binding to PMN membrane receptors
ChEMBL 510 12 1 9 3.9 CCCOc1c(OC)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO 10.1016/S0960-894X(01)80818-0
CHEMBL109738 15646 5 None - 1 Human 7.2 pKi = 7.2 Binding
Compound was tested for it''s ability to inhibit [3H]C18-PAF binding to PMN membrane receptorsCompound was tested for it''s ability to inhibit [3H]C18-PAF binding to PMN membrane receptors
ChEMBL 510 12 1 9 3.9 CCCOc1c(OC)cc(C2CCC(c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO 10.1016/S0960-894X(01)80818-0
44267834 17855 0 None - 1 Guinea pig 6.2 pKi = 6.2 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 584 25 0 4 9.5 CCCCCCCCCCCCCCCCOCC1(COC(=O)CCCCC[n+]2cccc3ccccc32)CSC1 10.1016/0960-894X(95)00173-Q
CHEMBL1177954 17855 0 None - 1 Guinea pig 6.2 pKi = 6.2 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 584 25 0 4 9.5 CCCCCCCCCCCCCCCCOCC1(COC(=O)CCCCC[n+]2cccc3ccccc32)CSC1 10.1016/0960-894X(95)00173-Q
CHEMBL8529 17855 0 None - 1 Guinea pig 6.2 pKi = 6.2 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 584 25 0 4 9.5 CCCCCCCCCCCCCCCCOCC1(COC(=O)CCCCC[n+]2cccc3ccccc32)CSC1 10.1016/0960-894X(95)00173-Q
44330448 215139 0 None - 1 Guinea pig 8.2 pKi = 8.2 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 596 5 0 8 6.4 CN(C)C(=O)O/N=C(\c1ccn2c1CS[C@@H]2c1cccnc1)c1cn(C(=O)N(C)C)c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00511-Q
CHEMBL99481 215139 0 None - 1 Guinea pig 8.2 pKi = 8.2 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 596 5 0 8 6.4 CN(C)C(=O)O/N=C(\c1ccn2c1CS[C@@H]2c1cccnc1)c1cn(C(=O)N(C)C)c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00511-Q
10550254 67062 0 None - 1 Guinea pig 8.2 pKi = 8.2 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 424 5 1 6 4.3 COC(=O)c1cccc2[nH]cc(C(=O)c3ccc(Cn4c(C)nc5cnccc54)cc3)c12 10.1021/jm970389+
CHEMBL174262 67062 0 None - 1 Guinea pig 8.2 pKi = 8.2 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 424 5 1 6 4.3 COC(=O)c1cccc2[nH]cc(C(=O)c3ccc(Cn4c(C)nc5cnccc54)cc3)c12 10.1021/jm970389+
131925 108549 17 None 2 2 Human 8.2 pKi = 8.2 Binding
In vitro inhibition of [3H]-C18 PAF binding to human platelet membrane Platelet activating factor receptor was determinedIn vitro inhibition of [3H]-C18 PAF binding to human platelet membrane Platelet activating factor receptor was determined
ChEMBL 510 12 1 9 3.9 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO 10.1016/S0960-894X(01)80446-7
CHEMBL299944 108549 17 None 2 2 Human 8.2 pKi = 8.2 Binding
In vitro inhibition of [3H]-C18 PAF binding to human platelet membrane Platelet activating factor receptor was determinedIn vitro inhibition of [3H]-C18 PAF binding to human platelet membrane Platelet activating factor receptor was determined
ChEMBL 510 12 1 9 3.9 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO 10.1016/S0960-894X(01)80446-7
10766924 66736 0 None - 1 Guinea pig 8.2 pKi = 8.2 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 475 8 0 8 4.5 COC(=O)c1cccc2c1c(C(=O)CCCCCn1c(C)nc3cnccc31)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL173304 66736 0 None - 1 Guinea pig 8.2 pKi = 8.2 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 475 8 0 8 4.5 COC(=O)c1cccc2c1c(C(=O)CCCCCn1c(C)nc3cnccc31)cn2C(=O)N(C)C 10.1021/jm970389+
10647327 175246 0 None - 1 Guinea pig 8.2 pKi = 8.2 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 453 4 1 7 4.2 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(O)c23)cc1 10.1021/jm970389+
CHEMBL435115 175246 0 None - 1 Guinea pig 8.2 pKi = 8.2 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 453 4 1 7 4.2 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cccc(O)c23)cc1 10.1021/jm970389+
131925 108549 17 None 2 2 Human 8.2 pKi = 8.2 Binding
Compound was tested for it''s ability to inhibit [3H]C18-PAF binding to human plateletCompound was tested for it''s ability to inhibit [3H]C18-PAF binding to human platelet
ChEMBL 510 12 1 9 3.9 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO 10.1016/S0960-894X(01)80818-0
CHEMBL299944 108549 17 None 2 2 Human 8.2 pKi = 8.2 Binding
Compound was tested for it''s ability to inhibit [3H]C18-PAF binding to human plateletCompound was tested for it''s ability to inhibit [3H]C18-PAF binding to human platelet
ChEMBL 510 12 1 9 3.9 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO 10.1016/S0960-894X(01)80818-0
131925 108549 17 None 2 2 Human 8.2 pKi = 8.2 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 510 12 1 9 3.9 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO 10.1021/jm00097a005
CHEMBL299944 108549 17 None 2 2 Human 8.2 pKi = 8.2 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 510 12 1 9 3.9 CCCOc1c(OC)cc([C@@H]2CC[C@@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(=O)(=O)CCO 10.1021/jm00097a005
21463481 17892 0 None - 1 Guinea pig 8.2 pKi = 8.2 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 616 24 1 5 8.6 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178051 17892 0 None - 1 Guinea pig 8.2 pKi = 8.2 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 616 24 1 5 8.6 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCC1 10.1016/0960-894X(95)00173-Q
CHEMBL12119 17892 0 None - 1 Guinea pig 8.2 pKi = 8.2 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 616 24 1 5 8.6 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CCC1 10.1016/0960-894X(95)00173-Q
10670617 173076 0 None - 1 Guinea pig 8.2 pKi = 8.2 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 437 4 0 6 4.5 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3ccccc23)cc1 10.1021/jm970389+
CHEMBL427121 173076 0 None - 1 Guinea pig 8.2 pKi = 8.2 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 437 4 0 6 4.5 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3ccccc23)cc1 10.1021/jm970389+
44370526 126506 0 None - 1 Guinea pig 6.2 pKi = 6.2 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 530 3 3 11 -0.2 C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](OCc6ccccc6)C34C(C(C)(C)C)[C@H]5O)[C@]21O 10.1021/jm0203985
CHEMBL347597 126506 0 None - 1 Guinea pig 6.2 pKi = 6.2 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 530 3 3 11 -0.2 C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](OCc6ccccc6)C34C(C(C)(C)C)[C@H]5O)[C@]21O 10.1021/jm0203985
44325288 213977 0 None - 1 Guinea pig 6.2 pKi = 6.2 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 443 5 1 5 3.9 O=C(c1ccccc1)c1cccc(NC(=O)[C@H]2CC(=O)N3[C@H](c4cccnc4)SC[C@@H]23)c1 10.1016/S0960-894X(01)80753-8
CHEMBL92585 213977 0 None - 1 Guinea pig 6.2 pKi = 6.2 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 443 5 1 5 3.9 O=C(c1ccccc1)c1cccc(NC(=O)[C@H]2CC(=O)N3[C@H](c4cccnc4)SC[C@@H]23)c1 10.1016/S0960-894X(01)80753-8
CHEMBL108238 13192 0 None - 1 Guinea pig 6.2 pKi = 6.2 Binding
Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor
ChEMBL 299 5 1 6 2.7 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)OCCSC)C1C 10.1021/jm00174a017
10437575 18084 0 None - 1 Guinea pig 7.2 pKi = 7.2 Binding
Compound was evaluated for competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompound was evaluated for competitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 424 10 0 5 4.9 CCCCCCOc1c(OC)cc(C(=O)Oc2ccc3c(ccc[n+]3C)c2)cc1OC 10.1021/jm00012a012
CHEMBL1179296 18084 0 None - 1 Guinea pig 7.2 pKi = 7.2 Binding
Compound was evaluated for competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompound was evaluated for competitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 424 10 0 5 4.9 CCCCCCOc1c(OC)cc(C(=O)Oc2ccc3c(ccc[n+]3C)c2)cc1OC 10.1021/jm00012a012
CHEMBL68407 18084 0 None - 1 Guinea pig 7.2 pKi = 7.2 Binding
Compound was evaluated for competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompound was evaluated for competitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 424 10 0 5 4.9 CCCCCCOc1c(OC)cc(C(=O)Oc2ccc3c(ccc[n+]3C)c2)cc1OC 10.1021/jm00012a012
10602311 136239 0 None - 1 Guinea pig 6.2 pKi = 6.2 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 531 5 0 6 6.3 Cc1nc2ccncc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)cc1 10.1021/jm970389+
CHEMBL367160 136239 0 None - 1 Guinea pig 6.2 pKi = 6.2 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 531 5 0 6 6.3 Cc1nc2ccncc2n1Cc1ccc(C(=O)c2cn(C(=O)N(C)C)c3cc(-c4ccc(F)cc4)ccc23)cc1 10.1021/jm970389+
44370810 126331 0 None - 1 Guinea pig 6.2 pKi = 6.2 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 453 1 4 11 -2.2 CN[C@@H]1C(C(C)(C)C)C23C(OC(=O)[C@@H]2O)OC24C(=O)OC1C32[C@@H](O)C1OC(=O)[C@@H](C)[C@@]14O 10.1021/jm0203985
CHEMBL345909 126331 0 None - 1 Guinea pig 6.2 pKi = 6.2 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 453 1 4 11 -2.2 CN[C@@H]1C(C(C)(C)C)C23C(OC(=O)[C@@H]2O)OC24C(=O)OC1C32[C@@H](O)C1OC(=O)[C@@H](C)[C@@]14O 10.1021/jm0203985
14983480 209905 0 None - 1 Guinea pig 6.2 pKi = 6.2 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 481 9 2 4 6.2 CC(CCCc1ccc(F)cc1)c1cc(O)c2c(c1)OC(C)(C)C1=C2CN(CCCC(=O)O)CC1 10.1021/jm00089a016
CHEMBL64094 209905 0 None - 1 Guinea pig 6.2 pKi = 6.2 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 481 9 2 4 6.2 CC(CCCc1ccc(F)cc1)c1cc(O)c2c(c1)OC(C)(C)C1=C2CN(CCCC(=O)O)CC1 10.1021/jm00089a016
45266349 201557 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Inhibition of platelet activating factor(PAF) by binding to PAF receptorInhibition of platelet activating factor(PAF) by binding to PAF receptor
ChEMBL 526 4 0 6 5.2 CN(C)C(=O)n1cc(C(=O)c2ccn3c2C[S+]([O-])[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00510-Z
CHEMBL538366 201557 0 None - 1 Rat 7.2 pKi = 7.2 Binding
Inhibition of platelet activating factor(PAF) by binding to PAF receptorInhibition of platelet activating factor(PAF) by binding to PAF receptor
ChEMBL 526 4 0 6 5.2 CN(C)C(=O)n1cc(C(=O)c2ccn3c2C[S+]([O-])[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00510-Z
CHEMBL100004 10939 0 None 81 4 Guinea pig 7.2 pKi = 7.2 Binding
Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor
ChEMBL 375 7 1 6 4.5 CCO/C(O)=C1/C(C)=NC(C)=C(C(=O)OCCSc2ccccc2)C1C 10.1021/jm00174a017
44330041 215127 0 None - 1 Guinea pig 6.2 pKi = 6.2 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 590 7 2 8 5.1 O=C(c1ccn2c1CS[C@@H]2c1cccnc1)c1cn(C(=O)NCCS(=O)(=O)O)c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00511-Q
CHEMBL99385 215127 0 None - 1 Guinea pig 6.2 pKi = 6.2 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 590 7 2 8 5.1 O=C(c1ccn2c1CS[C@@H]2c1cccnc1)c1cn(C(=O)NCCS(=O)(=O)O)c2cc(-c3ccc(F)cc3)ccc12 10.1016/0960-894X(95)00511-Q
14983500 210324 0 None - 1 Guinea pig 6.2 pKi = 6.2 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 495 10 1 4 6.5 COc1cc(C(C)CCCc2ccc(F)cc2)cc2c1C1=C(CCN(CCCC(=O)O)C1)C(C)(C)O2 10.1021/jm00089a016
CHEMBL66537 210324 0 None - 1 Guinea pig 6.2 pKi = 6.2 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 495 10 1 4 6.5 COc1cc(C(C)CCCc2ccc(F)cc2)cc2c1C1=C(CCN(CCCC(=O)O)C1)C(C)(C)O2 10.1021/jm00089a016
1859 7223 62 None 2 2 Guinea pig 8.2 pKi = 8.2 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00012a012
1860 7223 62 None 2 2 Guinea pig 8.2 pKi = 8.2 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00012a012
65889 7223 62 None 2 2 Guinea pig 8.2 pKi = 8.2 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00012a012
CHEMBL280164 7223 62 None 2 2 Guinea pig 8.2 pKi = 8.2 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00012a012
107757 8005 3 None - 1 Guinea pig 8.1 pKi = 8.1 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1016/0960-894X(95)00173-Q
1852 8005 3 None - 1 Guinea pig 8.1 pKi = 8.1 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1016/0960-894X(95)00173-Q
CHEMBL1180101 8005 3 None - 1 Guinea pig 8.1 pKi = 8.1 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1016/0960-894X(95)00173-Q
107757 8005 3 None - 1 Guinea pig 8.1 pKi = 8.1 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1016/0960-894X(95)00174-R
1852 8005 3 None - 1 Guinea pig 8.1 pKi = 8.1 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1016/0960-894X(95)00174-R
CHEMBL1180101 8005 3 None - 1 Guinea pig 8.1 pKi = 8.1 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 606 25 1 6 7.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COC(=O)N(C(=O)C)Cc1cccc[n+]1CC)OC 10.1016/0960-894X(95)00174-R
44330521 113994 0 None - 1 Guinea pig 7.2 pKi = 7.2 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 499 4 0 8 5.5 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3nccs3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL316666 113994 0 None - 1 Guinea pig 7.2 pKi = 7.2 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 499 4 0 8 5.5 CN(C)C(=O)n1cc(C(=O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3nccs3)cc21 10.1016/0960-894X(95)00511-Q
4507 187457 101 None -8 4 Guinea pig 4.1 pKi = 4.1 Binding
Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor
ChEMBL 360 5 1 7 2.6 CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc([N+](=O)[O-])c1 10.1021/jm00174a017
CHEMBL475534 187457 101 None -8 4 Guinea pig 4.1 pKi = 4.1 Binding
Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor
ChEMBL 360 5 1 7 2.6 CCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc([N+](=O)[O-])c1 10.1021/jm00174a017
44330460 215191 0 None - 1 Guinea pig 7.1 pKi = 7.1 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 583 7 1 8 5.8 CN(C)C(=O)n1cc(/C(=N/OCC(=O)O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
CHEMBL99773 215191 0 None - 1 Guinea pig 7.1 pKi = 7.1 Binding
Binding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranesBinding affinity for platelet activating factor receptor using [3H]PAF in rabbit platelet membranes
ChEMBL 583 7 1 8 5.8 CN(C)C(=O)n1cc(/C(=N/OCC(=O)O)c2ccn3c2CS[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00511-Q
10623837 67110 1 None - 1 Guinea pig 7.1 pKi = 7.1 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 460 5 1 4 6.3 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2c[nH]c3cc(-c4ccc(F)cc4)ccc23)cc1 10.1021/jm970389+
CHEMBL174454 67110 1 None - 1 Guinea pig 7.1 pKi = 7.1 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 460 5 1 4 6.3 Cc1nc2cnccc2n1Cc1ccc(C(=O)c2c[nH]c3cc(-c4ccc(F)cc4)ccc23)cc1 10.1021/jm970389+
44370515 126490 0 None - 1 Guinea pig 5.1 pKi = 5.1 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 482 1 3 12 -1.8 CC(=O)O[C@@H]1C(C(C)(C)C)C23C(OC(=O)[C@@H]2O)OC24C(=O)OC1C32[C@@H](O)C1OC(=O)[C@@H](C)[C@@]14O 10.1021/jm0203985
CHEMBL347433 126490 0 None - 1 Guinea pig 5.1 pKi = 5.1 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 482 1 3 12 -1.8 CC(=O)O[C@@H]1C(C(C)(C)C)C23C(OC(=O)[C@@H]2O)OC24C(=O)OC1C32[C@@H](O)C1OC(=O)[C@@H](C)[C@@]14O 10.1021/jm0203985
44353074 28107 0 None - 1 Mouse 6.1 pKi = 6.1 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 643 4 3 12 1.3 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@]34C5OC(=O)C3(OC3OC(=O)[C@H](OCc6c(F)c(F)c(N=[N+]=[N-])c(F)c6F)C34[C@H](C(C)(C)C)[C@H]5O)[C@@]12O 10.1021/jm020147w
CHEMBL131402 28107 0 None - 1 Mouse 6.1 pKi = 6.1 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 643 4 3 12 1.3 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@]34C5OC(=O)C3(OC3OC(=O)[C@H](OCc6c(F)c(F)c(N=[N+]=[N-])c(F)c6F)C34[C@H](C(C)(C)C)[C@H]5O)[C@@]12O 10.1021/jm020147w
10720226 136879 0 None - 1 Guinea pig 8.1 pKi = 8.1 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 501 5 0 9 4.4 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)s1)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL367786 136879 0 None - 1 Guinea pig 8.1 pKi = 8.1 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 501 5 0 9 4.4 COC(=O)c1cccc2c1c(C(=O)c1ccc(Cn3c(C)nc4cnccc43)s1)cn2C(=O)N(C)C 10.1021/jm970389+
45266349 201557 0 None - 1 Rat 8.1 pKi = 8.1 Binding
Inhibition of platelet activating factor(PAF) by binding to PAF receptorInhibition of platelet activating factor(PAF) by binding to PAF receptor
ChEMBL 526 4 0 6 5.2 CN(C)C(=O)n1cc(C(=O)c2ccn3c2C[S+]([O-])[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00510-Z
CHEMBL538366 201557 0 None - 1 Rat 8.1 pKi = 8.1 Binding
Inhibition of platelet activating factor(PAF) by binding to PAF receptorInhibition of platelet activating factor(PAF) by binding to PAF receptor
ChEMBL 526 4 0 6 5.2 CN(C)C(=O)n1cc(C(=O)c2ccn3c2C[S+]([O-])[C@@H]3c2cccnc2)c2ccc(-c3ccc(F)cc3)cc21 10.1016/0960-894X(95)00510-Z
10370137 18076 0 None - 1 Guinea pig 6.1 pKi = 6.1 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 416 14 0 5 4.6 CCCCCCOc1c(OC)cc(C(=O)OCCCC[n+]2ccccc2)cc1OC 10.1021/jm00012a012
CHEMBL1179260 18076 0 None - 1 Guinea pig 6.1 pKi = 6.1 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 416 14 0 5 4.6 CCCCCCOc1c(OC)cc(C(=O)OCCCC[n+]2ccccc2)cc1OC 10.1021/jm00012a012
CHEMBL66814 18076 0 None - 1 Guinea pig 6.1 pKi = 6.1 Binding
Competitive inhibition of Platelet activating factor receptor in rabbit-washed plateletsCompetitive inhibition of Platelet activating factor receptor in rabbit-washed platelets
ChEMBL 416 14 0 5 4.6 CCCCCCOc1c(OC)cc(C(=O)OCCCC[n+]2ccccc2)cc1OC 10.1021/jm00012a012
44370942 126423 0 None - 1 Guinea pig 5.1 pKi = 5.1 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 439 0 4 11 -2.4 C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](O)C34C(C(C)(C)C)[C@H]5N)[C@]21O 10.1021/jm0203985
CHEMBL346787 126423 0 None - 1 Guinea pig 5.1 pKi = 5.1 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 439 0 4 11 -2.4 C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](O)C34C(C(C)(C)C)[C@H]5N)[C@]21O 10.1021/jm0203985
6324617 196342 27 None - 1 Guinea pig 6.1 pKi = 6.1 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 424 0 3 10 -1.4 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6O)O[C@@]4(C(=O)O5)[C@@]12O 10.1021/jm0203985
CHEMBL514432 196342 27 None - 1 Guinea pig 6.1 pKi = 6.1 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 424 0 3 10 -1.4 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6O)O[C@@]4(C(=O)O5)[C@@]12O 10.1021/jm0203985
5312127 70093 1 None - 1 Human 8.1 pKi = 8.1 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 480 10 0 8 4.5 CCCOc1c(OC)cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(C)(=O)=O 10.1021/jm00097a005
CHEMBL1793831 70093 1 None - 1 Human 8.1 pKi = 8.1 Binding
Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationInhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparation
ChEMBL 480 10 0 8 4.5 CCCOc1c(OC)cc([C@H]2CC[C@H](c3cc(OC)c(OC)c(OC)c3)O2)cc1S(C)(=O)=O 10.1021/jm00097a005
44268122 17900 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL1178068 17900 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL12439 17900 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
CHEMBL12882 17900 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 618 24 1 6 7.6 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)O1 10.1016/0960-894X(95)00174-R
21463428 17896 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 637 26 1 4 10.4 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCC[n+]2cccc3ccccc32)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL1178060 17896 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 637 26 1 4 10.4 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCC[n+]2cccc3ccccc32)CCCC1 10.1016/0960-894X(95)00173-Q
CHEMBL12368 17896 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 637 26 1 4 10.4 CCCCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)CCCC[n+]2cccc3ccccc32)CCCC1 10.1016/0960-894X(95)00173-Q
10505183 136513 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 489 9 0 8 4.8 COC(=O)c1cccc2c1c(C(=O)CCCCCCn1c(C)nc3cnccc31)cn2C(=O)N(C)C 10.1021/jm970389+
CHEMBL367425 136513 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
Binding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranesBinding potency against Platelet activating factor (PAF) receptor using [3H]C18-PAF as radioligand on rabbit platelet membranes
ChEMBL 489 9 0 8 4.8 COC(=O)c1cccc2c1c(C(=O)CCCCCCn1c(C)nc3cnccc31)cn2C(=O)N(C)C 10.1021/jm970389+
44268105 17894 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 606 22 1 6 7.6 CCCCCCCCCCCCCCCCNC(=O)OC[C@@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
CHEMBL1178055 17894 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 606 22 1 6 7.6 CCCCCCCCCCCCCCCCNC(=O)OC[C@@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
CHEMBL12183 17894 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 606 22 1 6 7.6 CCCCCCCCCCCCCCCCNC(=O)OC[C@@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
44268194 18731 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 634 24 1 6 8.3 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
CHEMBL1182938 18731 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 634 24 1 6 8.3 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
CHEMBL273445 18731 0 None - 1 Guinea pig 8.0 pKi = 8.0 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 634 24 1 6 8.3 CCCCCCCCCCCCCCCCCCNC(=O)OC[C@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)S1 10.1016/0960-894X(95)00174-R
44353145 124266 0 None - 1 Mouse 7.1 pKi = 7.1 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 627 4 2 11 2.4 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34C5C[C@@H](C(C)(C)C)C36C(OC(=O)[C@@H]6OCc3c(F)c(F)c(N=[N+]=[N-])c(F)c3F)OC4(C(=O)O5)[C@@]12O 10.1021/jm020147w
CHEMBL339997 124266 0 None - 1 Mouse 7.1 pKi = 7.1 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 627 4 2 11 2.4 C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34C5C[C@@H](C(C)(C)C)C36C(OC(=O)[C@@H]6OCc3c(F)c(F)c(N=[N+]=[N-])c(F)c3F)OC4(C(=O)O5)[C@@]12O 10.1021/jm020147w
21321140 210132 0 None - 1 Guinea pig 5.1 pKi = 5.1 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 344 3 2 4 2.9 CNC(=O)CN1CCC2=C(C1)c1c(O)cc(C(C)C)cc1OC2(C)C 10.1021/jm00089a016
CHEMBL65089 210132 0 None - 1 Guinea pig 5.1 pKi = 5.1 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 344 3 2 4 2.9 CNC(=O)CN1CCC2=C(C1)c1c(O)cc(C(C)C)cc1OC2(C)C 10.1021/jm00089a016
CHEMBL108291 13317 0 None - 1 Guinea pig 6.0 pKi = 6.0 Binding
Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor
ChEMBL 389 7 1 6 4.9 CC1=NC(C)=C(C(=O)OCCSc2ccccc2)C(C)/C1=C(\O)OC(C)C 10.1021/jm00174a017
14983483 209483 0 None - 1 Guinea pig 6.0 pKi = 6.0 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 524 10 2 5 4.8 CNC(=O)CN1CCC2=C(C1)c1c(OCC(=O)O)cc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
CHEMBL61680 209483 0 None - 1 Guinea pig 6.0 pKi = 6.0 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 524 10 2 5 4.8 CNC(=O)CN1CCC2=C(C1)c1c(OCC(=O)O)cc(C(C)CCCc3ccc(F)cc3)cc1OC2(C)C 10.1021/jm00089a016
14983490 210137 0 None - 1 Guinea pig 6.0 pKi = 6.0 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 466 8 1 4 5.1 COc1cc(C(C)CCCc2ccc(F)cc2)cc2c1C1=C(CCN(CC(N)=O)C1)C(C)(C)O2 10.1021/jm00089a016
CHEMBL65144 210137 0 None - 1 Guinea pig 6.0 pKi = 6.0 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 466 8 1 4 5.1 COc1cc(C(C)CCCc2ccc(F)cc2)cc2c1C1=C(CCN(CC(N)=O)C1)C(C)(C)O2 10.1021/jm00089a016
44267808 18737 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 590 22 1 6 6.7 CCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL1182959 18737 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 590 22 1 6 6.7 CCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
CHEMBL274110 18737 0 None - 1 Guinea pig 7.0 pKi = 7.0 Binding
Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.Ability to displace [3H]PAF from its Platelet Activating Factor (PAF) receptor in rabbit platelet membrane in vitro.
ChEMBL 590 22 1 6 6.7 CCCCCCCCCCCCCCCCNC(=O)OCC1(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)COC1 10.1016/0960-894X(95)00173-Q
44325239 214223 0 None - 1 Guinea pig 4.0 pKi = 4.0 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 458 5 1 5 3.8 CN1C(=O)N2[C@@H](c3cccnc3)SC[C@H]2[C@@H]1C(=O)Nc1cccc(C(=O)c2ccccc2)c1 10.1016/S0960-894X(01)80753-8
CHEMBL94138 214223 0 None - 1 Guinea pig 4.0 pKi = 4.0 Binding
Inhibition of [3H]PAF binding to rabbit platelet membranesInhibition of [3H]PAF binding to rabbit platelet membranes
ChEMBL 458 5 1 5 3.8 CN1C(=O)N2[C@@H](c3cccnc3)SC[C@H]2[C@@H]1C(=O)Nc1cccc(C(=O)c2ccccc2)c1 10.1016/S0960-894X(01)80753-8
1859 7223 62 None 2 2 Guinea pig 7.0 pKi = 7.0 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00089a016
1860 7223 62 None 2 2 Guinea pig 7.0 pKi = 7.0 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00089a016
65889 7223 62 None 2 2 Guinea pig 7.0 pKi = 7.0 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00089a016
CHEMBL280164 7223 62 None 2 2 Guinea pig 7.0 pKi = 7.0 Binding
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesIn vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes
ChEMBL 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 10.1021/jm00089a016
44268190 18721 0 None - 1 Guinea pig 7.0 pKi = 7 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 655 24 0 6 9.2 CCCCCCCCCCCCCCCCOC[C@@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(=O)c2ccc(OC)cc2)S1 10.1016/0960-894X(95)00174-R
CHEMBL1182836 18721 0 None - 1 Guinea pig 7.0 pKi = 7 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 655 24 0 6 9.2 CCCCCCCCCCCCCCCCOC[C@@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(=O)c2ccc(OC)cc2)S1 10.1016/0960-894X(95)00174-R
CHEMBL268965 18721 0 None - 1 Guinea pig 7.0 pKi = 7 Binding
In vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranesIn vitro ability to displace [3H]PAF from PAF receptor in rabbit platelet membranes
ChEMBL 655 24 0 6 9.2 CCCCCCCCCCCCCCCCOC[C@@H]1C[C@@H](COC(=O)N(Cc2cccc[n+]2CC)C(=O)c2ccc(OC)cc2)S1 10.1016/0960-894X(95)00174-R
44370798 56148 0 None - 1 Guinea pig 6.0 pKi = 6 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 442 0 3 10 -1.4 C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](O)C34C(C(C)(C)C)[C@H]5F)[C@]21O 10.1021/jm0203985
CHEMBL156402 56148 0 None - 1 Guinea pig 6.0 pKi = 6 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membraneDisplacement of [3H]-WEB 2086 from Platelet activating factor receptor (guinea pig) transgenic mouse muscle membrane
ChEMBL 442 0 3 10 -1.4 C[C@@H]1C(=O)OC2[C@H](O)C34C5OC(=O)C3(OC3OC(=O)[C@H](O)C34C(C(C)(C)C)[C@H]5F)[C@]21O 10.1021/jm0203985
44353152 25708 0 None - 1 Mouse 5.0 pKi = 5 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 440 1 3 10 -0.9 COC1OC(=O)[C@H](O)C12[C@H](C(C)(C)C)[C@@H](O)C1OC(=O)C3[C@]4(O)[C@H](C[C@]132)OC(=O)[C@H]4C 10.1021/jm020147w
CHEMBL128592 25708 0 None - 1 Mouse 5.0 pKi = 5 Binding
Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)Displacement of [3H]-WEB 2086 from Platelet activating factor receptor (PAF)
ChEMBL 440 1 3 10 -0.9 COC1OC(=O)[C@H](O)C12[C@H](C(C)(C)C)[C@@H](O)C1OC(=O)C3[C@]4(O)[C@H](C[C@]132)OC(=O)[C@H]4C 10.1021/jm020147w
2451 117261 30 None - 1 Human 8.2 pIC50 = 8.2 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
Drug Central 392 1 0 5 4.4 Cc1nnc2n1-c1sc(Br)cc1C(c1ccccc1Cl)=NC2 None
CHEMBL32479 117261 30 None - 1 Human 8.2 pIC50 = 8.2 Binding
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.
Drug Central 392 1 0 5 4.4 Cc1nnc2n1-c1sc(Br)cc1C(c1ccccc1Cl)=NC2 None
108156 9767 52 None - 1 Human 8.9 pKd = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 11560941
108156 9767 52 None - 1 Human 8.9 pKd = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 1657923
1831 9767 52 None - 1 Human 8.9 pKd = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 11560941
1831 9767 52 None - 1 Human 8.9 pKd = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 1657923
1833 9767 52 None - 1 Human 8.9 pKd = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 11560941
1833 9767 52 None - 1 Human 8.9 pKd = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 1657923
CHEMBL1235246 9767 52 None - 1 Human 8.9 pKd = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 11560941
CHEMBL1235246 9767 52 None - 1 Human 8.9 pKd = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 1657923
DB02261 9767 52 None - 1 Human 8.9 pKd = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 11560941
DB02261 9767 52 None - 1 Human 8.9 pKd = 8.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 1657923
1859 7223 62 None -2 2 Human 7.7 pKd None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 11560941
1859 7223 62 None -2 2 Human 7.7 pKd None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 1657923
1859 7223 62 None -2 2 Human 7.7 pKd None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 7594622
1860 7223 62 None -2 2 Human 7.7 pKd None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 11560941
1860 7223 62 None -2 2 Human 7.7 pKd None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 1657923
1860 7223 62 None -2 2 Human 7.7 pKd None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 7594622
65889 7223 62 None -2 2 Human 7.7 pKd None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 11560941
65889 7223 62 None -2 2 Human 7.7 pKd None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 1657923
65889 7223 62 None -2 2 Human 7.7 pKd None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 7594622
CHEMBL280164 7223 62 None -2 2 Human 7.7 pKd None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 11560941
CHEMBL280164 7223 62 None -2 2 Human 7.7 pKd None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 1657923
CHEMBL280164 7223 62 None -2 2 Human 7.7 pKd None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 7594622
146417 10150 12 None 54 2 Human 8.4 pKd None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 355 3 1 4 4.6 Clc1cccc(c1)NC(=O)c1ccn2c1CSC2c1cccnc1 2831350
1839 10150 12 None 54 2 Human 8.4 pKd None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 355 3 1 4 4.6 Clc1cccc(c1)NC(=O)c1ccn2c1CSC2c1cccnc1 2831350
1858 10150 12 None 54 2 Human 8.4 pKd None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 355 3 1 4 4.6 Clc1cccc(c1)NC(=O)c1ccn2c1CSC2c1cccnc1 2831350
CHEMBL64716 10150 12 None 54 2 Human 8.4 pKd None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 355 3 1 4 4.6 Clc1cccc(c1)NC(=O)c1ccn2c1CSC2c1cccnc1 2831350
None 222968 0 3H-PAF - 1 Human 9.0 pKi = 9.0 Binding
NoneNone
PDSP KiDatabase 480 10 0 8 4.5 CCCOC1=C(C=C(C=C1S(=O)(=O)C)C2CCC(O2)C3=CC(=C(C(=C3)OC)OC)OC)OC None
6069 6790 0 3H-PAF 8 8 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 386 12 2 3 4.7 CCCCC[C@@H](/C=C/[C@H]1C[C@@H]2O[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2(F)F)O None
73755171 6790 0 3H-PAF 8 8 Human 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 386 12 2 3 4.7 CCCCC[C@@H](/C=C/[C@H]1C[C@@H]2O[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2(F)F)O None
6069 6790 0 3H-PAF 8 8 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 386 12 2 3 4.7 CCCCC[C@@H](/C=C/[C@H]1C[C@@H]2O[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2(F)F)O None
73755171 6790 0 3H-PAF 8 8 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase 386 12 2 3 4.7 CCCCC[C@@H](/C=C/[C@H]1C[C@@H]2O[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2(F)F)O None
135398737 7745 93 3H-PAF -416 90 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
38 7745 93 3H-PAF -416 90 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
722 7745 93 3H-PAF -416 90 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
CHEMBL42 7745 93 3H-PAF -416 90 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
DB00363 7745 93 3H-PAF -416 90 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 326 0 1 4 3.7 CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 None
1222 8445 49 3H-PAF -1659 32 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
3396 8445 49 3H-PAF -1659 32 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
85 8445 49 3H-PAF -1659 32 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
CHEMBL46516 8445 49 3H-PAF -1659 32 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
DB04842 8445 49 3H-PAF -1659 32 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 475 7 1 3 5.3 Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 None
1353 8692 93 3H-PAF -691 85 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
3559 8692 93 3H-PAF -691 85 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
86 8692 93 3H-PAF -691 85 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
CHEMBL54 8692 93 3H-PAF -691 85 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
DB00502 8692 93 3H-PAF -691 85 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 6 1 3 4.4 Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl None
135398745 9688 112 3H-PAF -512 65 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
47 9688 112 3H-PAF -512 65 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
CHEMBL715 9688 112 3H-PAF -512 65 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
DB00334 9688 112 3H-PAF -512 65 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 312 1 1 5 1.7 CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C None
2181 9902 46 3H-PAF -831 34 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
4830 9902 46 3H-PAF -831 34 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
92 9902 46 3H-PAF -831 34 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
CHEMBL440294 9902 46 3H-PAF -831 34 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
DB09286 9902 46 3H-PAF -831 34 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 375 7 1 4 2.6 O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N None
2337 10030 77 3H-PAF -112 62 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
50 10030 77 3H-PAF -112 62 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
5002 10030 77 3H-PAF -112 62 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
CHEMBL716 10030 77 3H-PAF -112 62 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
DB01224 10030 77 3H-PAF -112 62 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 383 5 1 6 2.9 OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 None
2389 10104 118 3H-PAF -2691 66 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
5073 10104 118 3H-PAF -2691 66 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
96 10104 118 3H-PAF -2691 66 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
CHEMBL85 10104 118 3H-PAF -2691 66 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
DB00734 10104 118 3H-PAF -2691 66 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 410 4 0 6 3.6 Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 None
2435 10362 83 3H-PAF -1949 48 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
60149 10362 83 3H-PAF -1949 48 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
98 10362 83 3H-PAF -1949 48 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
CHEMBL12713 10362 83 3H-PAF -1949 48 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
DB06144 10362 83 3H-PAF -1949 48 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 440 5 1 3 4.6 Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O None
2865 10915 73 3H-PAF -2041 53 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
59 10915 73 3H-PAF -2041 53 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
60854 10915 73 3H-PAF -2041 53 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
CHEMBL708 10915 73 3H-PAF -2041 53 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
DB00246 10915 73 3H-PAF -2041 53 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 412 4 1 5 3.8 O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2 None
103 10925 61 3H-PAF -831 53 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
2875 10925 61 3H-PAF -831 53 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
5736 10925 61 3H-PAF -831 53 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
CHEMBL285802 10925 61 3H-PAF -831 53 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
DB09225 10925 61 3H-PAF -831 53 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 331 4 0 3 4.9 CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C None
115237 62359 119 3H-PAF -4265 54 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
CHEMBL1621 62359 119 3H-PAF -4265 54 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 426 4 1 7 3.1 Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O None
46780481 114308 20 3H-PAF -5888 53 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
9903970 114308 20 3H-PAF -5888 53 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3187365 114308 20 3H-PAF -5888 53 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
CHEMBL3544974 114308 20 3H-PAF -5888 53 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 285 0 0 2 4.3 CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1 None
243 9976 91 3H-PAF -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3052762 9976 91 3H-PAF -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3502 9976 91 3H-PAF -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
CHEMBL117287 9976 91 3H-PAF -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
DB06480 9976 91 3H-PAF -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
44208932 147485 7 UNDEFINED -89125 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
CHEMBL381689 147485 7 UNDEFINED -89125 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
None 223272 0 3H-PAF -10471285 17 Rat 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 372 2 1 3 4.4 CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl None
6069 6790 0 3H-PAF 8 8 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 386 12 2 3 4.7 CCCCC[C@@H](/C=C/[C@H]1C[C@@H]2O[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2(F)F)O None
73755171 6790 0 3H-PAF 8 8 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 386 12 2 3 4.7 CCCCC[C@@H](/C=C/[C@H]1C[C@@H]2O[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2(F)F)O None
6069 6790 0 3H-PAF 8 8 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 386 12 2 3 4.7 CCCCC[C@@H](/C=C/[C@H]1C[C@@H]2O[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2(F)F)O None
73755171 6790 0 3H-PAF 8 8 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 386 12 2 3 4.7 CCCCC[C@@H](/C=C/[C@H]1C[C@@H]2O[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2(F)F)O None
None 222968 0 3H-PAF - 1 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 480 10 0 8 4.5 CCCOC1=C(C=C(C=C1S(=O)(=O)C)C2CCC(O2)C3=CC(=C(C(=C3)OC)OC)OC)OC None
6069 6790 0 3H-PAF 8 8 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 386 12 2 3 4.7 CCCCC[C@@H](/C=C/[C@H]1C[C@@H]2O[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2(F)F)O None
73755171 6790 0 3H-PAF 8 8 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 386 12 2 3 4.7 CCCCC[C@@H](/C=C/[C@H]1C[C@@H]2O[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2(F)F)O None
2451 117261 30 3H-PAF - 1 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 392 1 0 5 4.4 Cc1nnc2n1-c1sc(Br)cc1C(c1ccccc1Cl)=NC2 None
CHEMBL32479 117261 30 3H-PAF - 1 Human 7.8 pKi = 7.8 Binding
NoneNone
PDSP KiDatabase 392 1 0 5 4.4 Cc1nnc2n1-c1sc(Br)cc1C(c1ccccc1Cl)=NC2 None
None 223002 0 3H-PAF - 1 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 404 8 0 7 4.3 COC1=CC(=CC(=C1OC)OC)C2CCC(O2)C3=CC(=C(C(=C3)OC)OC)OC None
None 223001 0 3H-PAF - 1 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 356 6 0 5 3.8 CC1C(OC2=CC(=O)C(=CC12OC)CC=C)C3=CC(=C(C=C3)OC)OC None
1859 7223 62 3H-PAF -2 2 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl None
1860 7223 62 3H-PAF -2 2 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl None
65889 7223 62 3H-PAF -2 2 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl None
CHEMBL280164 7223 62 3H-PAF -2 2 Human 7.6 pKi = 7.6 Binding
NoneNone
PDSP KiDatabase 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl None
None 223001 0 3H-PAF - 1 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 356 6 0 5 3.8 CC1C(OC2=CC(=O)C(=CC12OC)CC=C)C3=CC(=C(C=C3)OC)OC None
5556 210039 27 3H-PAF - 1 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 342 1 0 4 4.2 Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2 None
CHEMBL646 210039 27 3H-PAF - 1 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 342 1 0 4 4.2 Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2 None
2118 210264 36 3H-PAF 24 2 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 308 1 0 4 3.6 Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2 None
CHEMBL661 210264 36 3H-PAF 24 2 Human 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 308 1 0 4 3.6 Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2 None
None 223002 0 3H-PAF - 1 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 404 8 0 7 4.3 COC1=CC(=CC(=C1OC)OC)C2CCC(O2)C3=CC(=C(C(=C3)OC)OC)OC None
6069 6790 0 3H-PAF 8 8 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 386 12 2 3 4.7 CCCCC[C@@H](/C=C/[C@H]1C[C@@H]2O[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2(F)F)O None
73755171 6790 0 3H-PAF 8 8 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 386 12 2 3 4.7 CCCCC[C@@H](/C=C/[C@H]1C[C@@H]2O[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2(F)F)O None
1859 7223 62 3H-PAF -2 2 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl None
1860 7223 62 3H-PAF -2 2 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl None
65889 7223 62 3H-PAF -2 2 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl None
CHEMBL280164 7223 62 3H-PAF -2 2 Human 7.4 pKi = 7.4 Binding
NoneNone
PDSP KiDatabase 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl None
4507 114852 101 None 1 5 Guinea pig 8.4 pKi = 8.4 Binding
Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor
Drug Central 360 5 1 7 3.4 CCOC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc([N+](=O)[O-])c1 None
CHEMBL3195219 114852 101 None 1 5 Guinea pig 8.4 pKi = 8.4 Binding
Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor Tested for inhibition of [3H]PAF binding to rabbit Platelet activating factor receptor
Drug Central 360 5 1 7 3.4 CCOC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc([N+](=O)[O-])c1 None
2812 11551 101 None -69 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)
Drug Central 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 None
CHEMBL104 11551 101 None -69 34 Human 8.3 pKi = 8.3 Binding
DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)DRUGMATRIX: Platelet Activating Factor (PAF) radioligand binding (ligand: [3H] PAF)
Drug Central 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 None
65927 210003 26 3H-PAF 5 2 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 425 5 1 5 5.2 O=C(c1ccccc1)c1cccc(NC(=O)c2ccn3c2CSC3c2cccnc2)c1 None
CHEMBL64449 210003 26 3H-PAF 5 2 Human 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 425 5 1 5 5.2 O=C(c1ccccc1)c1cccc(NC(=O)c2ccn3c2CSC3c2cccnc2)c1 None
2118 210264 36 3H-PAF 24 2 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 308 1 0 4 3.6 Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2 None
CHEMBL661 210264 36 3H-PAF 24 2 Human 5.3 pKi = 5.3 Binding
NoneNone
PDSP KiDatabase 308 1 0 4 3.6 Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2 None
2118 210264 36 None 24 2 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 308 1 0 4 3.6 Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2 None
CHEMBL661 210264 36 None 24 2 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 308 1 0 4 3.6 Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2 None
5556 210039 27 None - 1 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 342 1 0 4 4.2 Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2 None
CHEMBL646 210039 27 None - 1 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 342 1 0 4 4.2 Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2 None
107681 8004 29 3H-PAF - 1 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 592 27 1 8 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)(OCC[n+]1ccsc1)[O-])OC None
6079 8004 29 3H-PAF - 1 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 592 27 1 8 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)(OCC[n+]1ccsc1)[O-])OC None
CHEMBL295212 8004 29 3H-PAF - 1 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 592 27 1 8 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)(OCC[n+]1ccsc1)[O-])OC None
65927 210003 26 3H-PAF 5 2 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 425 5 1 5 5.2 O=C(c1ccccc1)c1cccc(NC(=O)c2ccn3c2CSC3c2cccnc2)c1 None
CHEMBL64449 210003 26 3H-PAF 5 2 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 425 5 1 5 5.2 O=C(c1ccccc1)c1cccc(NC(=O)c2ccn3c2CSC3c2cccnc2)c1 None
146157361 223003 0 3H-PAF - 1 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 424 0 3 10 -1.4 CC1C(=O)OC2C1(C34C(=O)OC5C3(C2O)C6(C(C5)C(C)(C)C)C(C(=O)OC6O4)O)O None
107681 8004 29 3H-PAF - 1 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 592 27 1 8 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)(OCC[n+]1ccsc1)[O-])OC None
6079 8004 29 3H-PAF - 1 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 592 27 1 8 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)(OCC[n+]1ccsc1)[O-])OC None
CHEMBL295212 8004 29 3H-PAF - 1 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 592 27 1 8 6.5 CCCCCCCCCCCCCCCCCCNC(=O)OCC(COP(=O)(OCC[n+]1ccsc1)[O-])OC None
5556 210039 27 3H-PAF - 1 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 342 1 0 4 4.2 Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2 None
CHEMBL646 210039 27 3H-PAF - 1 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 342 1 0 4 4.2 Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1Cl)=NC2 None
1859 7223 62 3H-PAF -2 2 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl None
1860 7223 62 3H-PAF -2 2 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl None
65889 7223 62 3H-PAF -2 2 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl None
CHEMBL280164 7223 62 3H-PAF -2 2 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl None
2451 117261 30 3H-PAF - 1 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 392 1 0 5 4.4 Cc1nnc2n1-c1sc(Br)cc1C(c1ccccc1Cl)=NC2 None
CHEMBL32479 117261 30 3H-PAF - 1 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 392 1 0 5 4.4 Cc1nnc2n1-c1sc(Br)cc1C(c1ccccc1Cl)=NC2 None
146157361 223003 0 3H-PAF - 1 Human 6.0 pKi = 6.0 Binding
NoneNone
PDSP KiDatabase 424 0 3 10 -1.4 CC1C(=O)OC2C1(C34C(=O)OC5C3(C2O)C6(C(C5)C(C)(C)C)C(C(=O)OC6O4)O)O None
119368 8459 0 None - 1 Human 10.3 pKi = 10.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 464 10 0 5 7.1 CN(CCN(c1scc(n1)c1c(cc(cc1C(C)C)C(C)C)C(C)C)Cc1cccnc1)C 8395255
1856 8459 0 None - 1 Human 10.3 pKi = 10.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 464 10 0 5 7.1 CN(CCN(c1scc(n1)c1c(cc(cc1C(C)C)C(C)C)C(C)C)Cc1cccnc1)C 8395255
CHEMBL1628662 8459 0 None - 1 Human 10.3 pKi = 10.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 464 10 0 5 7.1 CN(CCN(c1scc(n1)c1c(cc(cc1C(C)C)C(C)C)C(C)C)Cc1cccnc1)C 8395255
10103 10189 72 None -933 3 Human 5.4 pKi = 5.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 415 2 0 3 5.6 Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 16220969
133017 10189 72 None -933 3 Human 5.4 pKi = 5.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 415 2 0 3 5.6 Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 16220969
2413 10189 72 None -933 3 Human 5.4 pKi = 5.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 415 2 0 3 5.6 Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 16220969
CHEMBL91397 10189 72 None -933 3 Human 5.4 pKi = 5.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 415 2 0 3 5.6 Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 16220969
DB11614 10189 72 None -933 3 Human 5.4 pKi = 5.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 415 2 0 3 5.6 Cc1cncc(c1)CN1CCC(=C2c3ccc(cc3CCc3c2nccc3)Cl)CC1 16220969
1862 8577 0 None - 1 Mouse 6.2 pKi = 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 424 0 3 10 -1.4 O=C1O[C@@H]2[C@@]([C@@H]1C)(O)[C@@]13C4(C2O)[C@H](OC3=O)C[C@H](C24[C@H](O1)OC(=O)C2O)C(C)(C)C 12190325
1862 8577 0 None - 1 Mouse 6.2 pKi = 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 424 0 3 10 -1.4 O=C1O[C@@H]2[C@@]([C@@H]1C)(O)[C@@]13C4(C2O)[C@H](OC3=O)C[C@H](C24[C@H](O1)OC(=O)C2O)C(C)(C)C 12570381
441294 8577 0 None - 1 Mouse 6.2 pKi = 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 424 0 3 10 -1.4 O=C1O[C@@H]2[C@@]([C@@H]1C)(O)[C@@]13C4(C2O)[C@H](OC3=O)C[C@H](C24[C@H](O1)OC(=O)C2O)C(C)(C)C 12190325
441294 8577 0 None - 1 Mouse 6.2 pKi = 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 424 0 3 10 -1.4 O=C1O[C@@H]2[C@@]([C@@H]1C)(O)[C@@]13C4(C2O)[C@H](OC3=O)C[C@H](C24[C@H](O1)OC(=O)C2O)C(C)(C)C 12570381
1859 7223 62 None -2 2 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 8380690
1859 7223 62 None -2 2 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 8798529
1860 7223 62 None -2 2 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 8380690
1860 7223 62 None -2 2 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 8798529
65889 7223 62 None -2 2 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 8380690
65889 7223 62 None -2 2 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 8798529
CHEMBL280164 7223 62 None -2 2 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 8380690
CHEMBL280164 7223 62 None -2 2 Human 6.4 pKi = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 455 4 0 7 3.4 O=C(N1CCOCC1)CCc1sc2c(c1)C(=NCc1n2c(C)nn1)c1ccccc1Cl 8798529
3426 9014 0 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 480 10 0 8 4.5 CCCOc1c(OC)cc(cc1S(=O)(=O)C)[C@@H]1CC[C@H](O1)c1cc(OC)c(c(c1)OC)OC 2841449
9934870 9014 0 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 480 10 0 8 4.5 CCCOc1c(OC)cc(cc1S(=O)(=O)C)[C@@H]1CC[C@H](O1)c1cc(OC)c(c(c1)OC)OC 2841449
154087 7019 18 None 2 2 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 479 4 0 6 4.6 C#Cc1cccc2c1c(cn2C(=O)N(C)C)C(=O)c1ccc(c(c1)F)Cn1c(C)nc2c1ccnc2 9151941
1850 7019 18 None 2 2 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 479 4 0 6 4.6 C#Cc1cccc2c1c(cn2C(=O)N(C)C)C(=O)c1ccc(c(c1)F)Cn1c(C)nc2c1ccnc2 9151941
CHEMBL369225 7019 18 None 2 2 Human 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 479 4 0 6 4.6 C#Cc1cccc2c1c(cn2C(=O)N(C)C)C(=O)c1ccc(c(c1)F)Cn1c(C)nc2c1ccnc2 9151941
1863 8578 0 None - 1 Mouse 4.9 pKi None 4.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 440 0 4 11 -2.4 O=C1O[C@@H]2[C@@]([C@@H]1C)(O)[C@@]13C4(C2O)[C@H](OC3=O)[C@@H]([C@H](C24[C@H](O1)OC(=O)C2O)C(C)(C)C)O 12190325
441295 8578 0 None - 1 Mouse 4.9 pKi None 4.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 440 0 4 11 -2.4 O=C1O[C@@H]2[C@@]([C@@H]1C)(O)[C@@]13C4(C2O)[C@H](OC3=O)[C@@H]([C@H](C24[C@H](O1)OC(=O)C2O)C(C)(C)C)O 12190325
1864 8579 0 None - 1 Mouse 5.0 pKi None 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 424 0 3 10 -1.4 O=C1O[C@@H]2[C@@]([C@@H]1C)(O)[C@@]13C4(C2)[C@H](OC3=O)[C@@H]([C@H](C24[C@H](O1)OC(=O)C2O)C(C)(C)C)O 12190325
441296 8579 0 None - 1 Mouse 5.0 pKi None 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 424 0 3 10 -1.4 O=C1O[C@@H]2[C@@]([C@@H]1C)(O)[C@@]13C4(C2)[C@H](OC3=O)[C@@H]([C@H](C24[C@H](O1)OC(=O)C2O)C(C)(C)C)O 12190325
1843 6961 0 None - 1 Mouse 5.1 pKi None 5.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 439 0 4 11 -2.4 O=C1O[C@@H]2[C@@](C1C)(O)[C@]13C4(C2O)C(OC3=O)[C@H](C(C24C(O1)OC(=O)[C@@H]2O)C(C)(C)C)N 12570381
73755017 6961 0 None - 1 Mouse 5.1 pKi None 5.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 439 0 4 11 -2.4 O=C1O[C@@H]2[C@@](C1C)(O)[C@]13C4(C2O)C(OC3=O)[C@H](C(C24C(O1)OC(=O)[C@@H]2O)C(C)(C)C)N 12570381
1846 6963 0 None - 1 Mouse 5.1 pKi None 5.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 482 1 3 12 -1.8 CC(=O)OC1C(C(C)(C)C)C23C45C1OC(=O)[C@@]5(OC2OC(=O)[C@@H]3O)[C@@]1([C@H](C4O)OC(=O)C1C)O 12570381
73755020 6963 0 None - 1 Mouse 5.1 pKi None 5.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 482 1 3 12 -1.8 CC(=O)OC1C(C(C)(C)C)C23C45C1OC(=O)[C@@]5(OC2OC(=O)[C@@H]3O)[C@@]1([C@H](C4O)OC(=O)C1C)O 12570381
1848 6968 0 None - 1 Mouse 5.4 pKi None 5.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 440 0 4 11 -2.4 O=C1O[C@@H]2[C@@](C1C)(O)[C@]13C4(C2O)C(OC3=O)[C@@H](C(C24C(O1)OC(=O)[C@@H]2O)C(C)(C)C)O 12570381
58761009 6968 0 None - 1 Mouse 5.4 pKi None 5.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 440 0 4 11 -2.4 O=C1O[C@@H]2[C@@](C1C)(O)[C@]13C4(C2O)C(OC3=O)[C@@H](C(C24C(O1)OC(=O)[C@@H]2O)C(C)(C)C)O 12570381
1847 6964 0 None - 1 Mouse 5.6 pKi None 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 558 3 3 12 -0.6 O=C(O[C@H]1C(C(C)(C)C)C23C45C1OC(=O)[C@@]5(OC2OC(=O)[C@@H]3O)[C@@]1([C@H](C4O)OC(=O)C1C)O)Cc1ccccc1 12570381
73755021 6964 0 None - 1 Mouse 5.6 pKi None 5.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 558 3 3 12 -0.6 O=C(O[C@H]1C(C(C)(C)C)C23C45C1OC(=O)[C@@]5(OC2OC(=O)[C@@H]3O)[C@@]1([C@H](C4O)OC(=O)C1C)O)Cc1ccccc1 12570381
1837 6794 0 None - 1 Mouse 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 530 3 3 11 -0.2 O=C1OC2C3([C@H]1OCc1ccccc1)C([C@H](C1C43[C@@](O2)(C(=O)O1)[C@@]1([C@H](C4O)OC(=O)C1C)O)O)C(C)(C)C 12570381
73755012 6794 0 None - 1 Mouse 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 530 3 3 11 -0.2 O=C1OC2C3([C@H]1OCc1ccccc1)C([C@H](C1C43[C@@](O2)(C(=O)O1)[C@@]1([C@H](C4O)OC(=O)C1C)O)O)C(C)(C)C 12570381
1844 6959 0 None - 1 Mouse 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 467 2 4 11 -1.8 CCN[C@H]1C(C(C)(C)C)C23C45C1OC(=O)[C@@]5(OC2OC(=O)[C@@H]3O)[C@@]1([C@H](C4O)OC(=O)C1C)O 12570381
73755018 6959 0 None - 1 Mouse 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 467 2 4 11 -1.8 CCN[C@H]1C(C(C)(C)C)C23C45C1OC(=O)[C@@]5(OC2OC(=O)[C@@H]3O)[C@@]1([C@H](C4O)OC(=O)C1C)O 12570381
1861 8576 0 None - 1 Mouse 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 0 2 9 -0.3 O=C1O[C@@H]2[C@@]([C@@H]1C)(O)[C@@]13C4(C2)[C@H](OC3=O)C[C@H](C24[C@H](O1)OC(=O)C2O)C(C)(C)C 12190325
441293 8576 0 None - 1 Mouse 5.8 pKi None 5.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 408 0 2 9 -0.3 O=C1O[C@@H]2[C@@]([C@@H]1C)(O)[C@@]13C4(C2)[C@H](OC3=O)C[C@H](C24[C@H](O1)OC(=O)C2O)C(C)(C)C 12190325
1841 6957 0 None - 1 Mouse 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 442 0 3 10 -1.4 O=C1O[C@@H]2[C@@](C1C)(O)[C@]13C4(C2O)C(OC3=O)C(C(C24C(O1)OC(=O)[C@@H]2O)C(C)(C)C)F 12570381
73755015 6957 0 None - 1 Mouse 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 442 0 3 10 -1.4 O=C1O[C@@H]2[C@@](C1C)(O)[C@]13C4(C2O)C(OC3=O)C(C(C24C(O1)OC(=O)[C@@H]2O)C(C)(C)C)F 12570381
1838 6792 0 None - 1 Mouse 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 530 3 3 11 -0.2 O=C1OC2C3([C@H]1OCc1ccccc1)C([C@@H](C1C43[C@@](O2)(C(=O)O1)[C@@]1([C@H](C4O)OC(=O)C1C)O)O)C(C)(C)C 12570381
73755013 6792 0 None - 1 Mouse 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 530 3 3 11 -0.2 O=C1OC2C3([C@H]1OCc1ccccc1)C([C@@H](C1C43[C@@](O2)(C(=O)O1)[C@@]1([C@H](C4O)OC(=O)C1C)O)O)C(C)(C)C 12570381
1845 6960 0 None - 1 Mouse 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 453 1 4 11 -2.2 CN[C@@H]1C2OC(=O)[C@@]34C2(C2(C1C(C)(C)C)C(O3)OC(=O)[C@@H]2O)C(O)[C@H]1[C@]4(O)C(C(=O)O1)C 12570381
73755019 6960 0 None - 1 Mouse 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 453 1 4 11 -2.2 CN[C@@H]1C2OC(=O)[C@@]34C2(C2(C1C(C)(C)C)C(O3)OC(=O)[C@@H]2O)C(O)[C@H]1[C@]4(O)C(C(=O)O1)C 12570381
1842 6962 0 None - 1 Mouse 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None [N-]=[N]=N[C@H]1C(C(C)(C)C)C23C45C1OC(=O)[C@@]5(OC2OC(=O)[C@@H]3O)[C@@]1([C@H](C4O)OC(=O)C1C)O 12570381
73755016 6962 0 None - 1 Mouse 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None [N-]=[N]=N[C@H]1C(C(C)(C)C)C23C45C1OC(=O)[C@@]5(OC2OC(=O)[C@@H]3O)[C@@]1([C@H](C4O)OC(=O)C1C)O 12570381
1836 6793 0 None - 1 Mouse 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 514 3 2 10 0.9 O=C1OC2C3([C@H]1OCc1ccccc1)C(CC1C43[C@@](O2)(C(=O)O1)[C@@]1([C@H](C4O)OC(=O)C1C)O)C(C)(C)C 12570381
73755011 6793 0 None - 1 Mouse 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 514 3 2 10 0.9 O=C1OC2C3([C@H]1OCc1ccccc1)C(CC1C43[C@@](O2)(C(=O)O1)[C@@]1([C@H](C4O)OC(=O)C1C)O)C(C)(C)C 12570381
115002 7483 0 None - 1 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 595 6 0 9 6.1 COc1ccc(cc1OC)SCC(=S)N1CCc2c(C1)sc1c2C(=NCc2n1c(C)nn2)c1ccccc1Cl 8380690
1851 7483 0 None - 1 Human 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 595 6 0 9 6.1 COc1ccc(cc1OC)SCC(=S)N1CCc2c(C1)sc1c2C(=NCc2n1c(C)nn2)c1ccccc1Cl 8380690
1835 6791 0 None - 1 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 532 3 2 10 0.8 O=C1OC2C3([C@H]1OCc1ccccc1)C([C@@H](C1C43[C@@](O2)(C(=O)O1)[C@@]1([C@H](C4O)OC(=O)C1C)O)F)C(C)(C)C 12570381
73755010 6791 0 None - 1 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 532 3 2 10 0.8 O=C1OC2C3([C@H]1OCc1ccccc1)C([C@@H](C1C43[C@@](O2)(C(=O)O1)[C@@]1([C@H](C4O)OC(=O)C1C)O)F)C(C)(C)C 12570381
1840 6956 0 None - 1 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 458 0 3 10 -1.2 O=C1O[C@@H]2[C@@](C1C)(O)[C@]13C4(C2O)C(OC3=O)C(C(C24C(O1)OC(=O)[C@@H]2O)C(C)(C)C)Cl 12570381
73755014 6956 0 None - 1 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 458 0 3 10 -1.2 O=C1O[C@@H]2[C@@](C1C)(O)[C@]13C4(C2O)C(OC3=O)C(C(C24C(O1)OC(=O)[C@@H]2O)C(C)(C)C)Cl 12570381
108156 9767 52 None - 1 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 1657923
108156 9767 52 None - 1 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 8798529
1831 9767 52 None - 1 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 1657923
1831 9767 52 None - 1 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 8798529
1833 9767 52 None - 1 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 1657923
1833 9767 52 None - 1 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 8798529
CHEMBL1235246 9767 52 None - 1 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 1657923
CHEMBL1235246 9767 52 None - 1 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 8798529
DB02261 9767 52 None - 1 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 1657923
DB02261 9767 52 None - 1 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 523 25 0 7 5.6 CCCCCCCCCCCCCCCCOC[C@@H](OC(=O)C)COP(=O)(OCC[N+](C)(C)C)[O-] 8798529
146417 10150 12 None 54 2 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 355 3 1 4 4.6 Clc1cccc(c1)NC(=O)c1ccn2c1CSC2c1cccnc1 2831350
1839 10150 12 None 54 2 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 355 3 1 4 4.6 Clc1cccc(c1)NC(=O)c1ccn2c1CSC2c1cccnc1 2831350
1858 10150 12 None 54 2 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 355 3 1 4 4.6 Clc1cccc(c1)NC(=O)c1ccn2c1CSC2c1cccnc1 2831350
CHEMBL64716 10150 12 None 54 2 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 355 3 1 4 4.6 Clc1cccc(c1)NC(=O)c1ccn2c1CSC2c1cccnc1 2831350
1849 7018 3 None 6 2 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 618 6 0 7 2.6 CC(=O)OC[n+]1cccc(c1)[C@H]1SCc2n1ccc2C(=O)c1cn(c2c1ccc(c2)c1ccc(cc1)F)C(=O)N(C)C.[Cl-] 8667228
9830503 7018 3 None 6 2 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 618 6 0 7 2.6 CC(=O)OC[n+]1cccc(c1)[C@H]1SCc2n1ccc2C(=O)c1cn(c2c1ccc(c2)c1ccc(cc1)F)C(=O)N(C)C.[Cl-] 8667228
CHEMBL1183764 7018 3 None 6 2 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 618 6 0 7 2.6 CC(=O)OC[n+]1cccc(c1)[C@H]1SCc2n1ccc2C(=O)c1cn(c2c1ccc(c2)c1ccc(cc1)F)C(=O)N(C)C.[Cl-] 8667228
CHEMBL317090 7018 3 None 6 2 Human 9.5 pKi None 9.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 618 6 0 7 2.6 CC(=O)OC[n+]1cccc(c1)[C@H]1SCc2n1ccc2C(=O)c1cn(c2c1ccc(c2)c1ccc(cc1)F)C(=O)N(C)C.[Cl-] 8667228