Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	145971909	164148	0	None	11	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	411	11	2	6	4.8	CCCC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4217198	164148	0	None	11	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	411	11	2	6	4.8	CCCC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	66978356	163156	0	None	10	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4204996	163156	0	None	10	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	127027876	138946	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	4.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3794302	138946	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	4.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	145978309	163200	0	None	27	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	429	12	2	6	4.8	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CCCCF	10.1016/j.bmc.2017.11.035
	CHEMBL4205480	163200	0	None	27	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	429	12	2	6	4.8	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CCCCF	10.1016/j.bmc.2017.11.035
	127029692	138874	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	423	5	2	6	4.1	Cc1cc(OC[C@H]2[C@@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793515	138874	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	423	5	2	6	4.1	Cc1cc(OC[C@H]2[C@@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	11855868	152012	0	None	24	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	152012	0	None	24	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855865	152743	0	None	35	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	152743	0	None	35	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	127026955	138920	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	5	2	6	4.4	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc(C)c1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794016	138920	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	5	2	6	4.4	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc(C)c1Cl	10.1016/j.bmcl.2016.03.110
	1883	3033	71	None	-2	10	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	1916	3033	71	None	-2	10	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	5280360	3033	71	None	-2	10	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	913	3033	71	None	-2	10	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	CHEMBL548	3033	71	None	-2	10	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	DB00917	3033	71	None	-2	10	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	18376258	194228	0	None	-	1	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	465	9	1	3	5.4	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559065	194228	0	None	-	1	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	465	9	1	3	5.4	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	127026956	138896	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cc(Cl)c(Cl)cc3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793862	138896	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cc(Cl)c(Cl)cc3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	126495400	138791	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3792632	138791	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	1929	1575	46	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	9890801	1575	46	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	CHEMBL563646	1575	46	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	DB12022	1575	46	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	67082748	163811	0	None	9	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	451	10	2	6	5.0	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CCC(F)(F)F	10.1016/j.bmc.2017.11.035
	CHEMBL4212770	163811	0	None	9	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	451	10	2	6	5.0	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CCC(F)(F)F	10.1016/j.bmc.2017.11.035
	15979081	163288	0	None	5	3	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCCC(C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4206444	163288	0	None	5	3	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCCC(C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	127051063	139792	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3C(F)(F)F)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806284	139792	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3C(F)(F)F)O2)n1	10.1021/acsmedchemlett.5b00455
	127027877	138889	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	443	5	2	6	4.4	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793802	138889	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	443	5	2	6	4.4	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	16725337	149069	0	None	4	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	149069	0	None	4	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11294085	136728	0	None	1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	458	12	2	7	4.0	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCCCF)CCC2)n1	10.1016/j.bmc.2017.11.035
	CHEMBL3751951	136728	0	None	1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	458	12	2	7	4.0	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCCCF)CCC2)n1	10.1016/j.bmc.2017.11.035
	127028169	138960	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	6	2	6	4.4	CCc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794466	138960	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	6	2	6	4.4	CCc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	118352160	138899	0	None	7079	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	423	5	2	6	4.1	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793892	138899	0	None	7079	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	423	5	2	6	4.1	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	127027874	138833	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793045	138833	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	127027874	138833	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3793045	138833	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	127051656	139764	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(OC(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805981	139764	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(OC(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	89443871	150913	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	8	2	4	5.5	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(C)ccc(OCC(=O)O)c1C	nan
	CHEMBL3961932	150913	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	8	2	4	5.5	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(C)ccc(OCC(=O)O)c1C	nan
	89443827	143581	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	395	7	3	4	4.9	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(O)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3903635	143581	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	395	7	3	4	4.9	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(O)cc(-c2cccc(F)c2)c1	nan
	18376082	193254	0	None	-	1	Rat	9.0	pEC50	=	9.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	472	9	1	5	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2nccs2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL541517	193254	0	None	-	1	Rat	9.0	pEC50	=	9.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	472	9	1	5	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2nccs2)cc1	10.1016/j.bmcl.2009.01.059
	145977227	163455	0	None	-1	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	437	10	2	6	5.2	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CC1CCCC1	10.1016/j.bmc.2017.11.035
	CHEMBL4208379	163455	0	None	-1	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	437	10	2	6	5.2	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CC1CCCC1	10.1016/j.bmc.2017.11.035
	10315	2881	20	None	1659	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	44230575	2881	20	None	1659	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	CHEMBL3707245	2881	20	None	1659	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	126495463	139777	0	None	69	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	6	2	6	3.5	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806130	139777	0	None	69	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	6	2	6	3.5	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	11502897	142261	0	None	43	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	142261	0	None	43	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855870	145747	0	None	467	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	145747	0	None	467	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855868	152012	0	None	24	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	152012	0	None	24	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855865	152743	0	None	35	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	152743	0	None	35	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	44230722	171163	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	489	10	2	7	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4467099	171163	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	489	10	2	7	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	11855868	152012	0	None	24	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	152012	0	None	24	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	127026953	138969	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	439	6	2	7	3.8	COc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794585	138969	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	439	6	2	7	3.8	COc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	1883	3033	71	None	-6	10	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	1916	3033	71	None	-6	10	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	5280360	3033	71	None	-6	10	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	913	3033	71	None	-6	10	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	CHEMBL548	3033	71	None	-6	10	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	DB00917	3033	71	None	-6	10	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	126495398	139681	0	None	416	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	403	7	2	6	3.9	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805044	139681	0	None	416	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	403	7	2	6	3.9	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	89443586	145152	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3916133	145152	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	118517489	143159	0	None	-18	3	Human	8.0	pEC50	=	8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	CHEMBL3900245	143159	0	None	-18	3	Human	8.0	pEC50	=	8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	92135977	152363	0	None	-141	4	Human	8.0	pEC50	=	8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	CHEMBL3974652	152363	0	None	-141	4	Human	8.0	pEC50	=	8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	8541	2899	1	None	-66069	4	Human	5.0	pEC50	=	5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	9824353	2899	1	None	-66069	4	Human	5.0	pEC50	=	5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL292964	2899	1	None	-66069	4	Human	5.0	pEC50	=	5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	59465571	145752	0	None	-1	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	386	12	2	3	5.6	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3920796	145752	0	None	-1	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	386	12	2	3	5.6	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	118517361	152836	0	None	-107	3	Human	6.0	pEC50	=	6.0	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	CHEMBL3978590	152836	0	None	-107	3	Human	6.0	pEC50	=	6.0	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	11955384	147005	0	None	33	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	360	8	2	3	4.4	CC(C)(C)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3930718	147005	0	None	33	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	360	8	2	3	4.4	CC(C)(C)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	45268715	194302	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccccc2CCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559760	194302	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccccc2CCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	16750455	150740	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	342	7	1	2	5.2	CC(C)(C)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3960352	150740	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	342	7	1	2	5.2	CC(C)(C)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	53259980	175795	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1cccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)c1	10.1021/acs.jmedchem.8b00808
	CHEMBL4566584	175795	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1cccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)c1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595789	175795	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1cccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)c1	10.1021/acs.jmedchem.8b00808
	126495507	138849	0	None	154	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	425	5	1	5	5.1	Cc1cc(OC[C@H]2[C@@H](F)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793167	138849	0	None	154	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	425	5	1	5	5.1	Cc1cc(OC[C@H]2[C@@H](F)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	71515776	153822	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.5	CC(Nc1c(F)ccc(OCC(=O)O)c1F)c1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3986985	153822	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.5	CC(Nc1c(F)ccc(OCC(=O)O)c1F)c1cc(-c2cccc(F)c2)ccc1F	nan
	44304164	201543	0	None	-	1	Mouse	8.0	pEC50	=	8.0	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	378	11	3	4	3.6	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64483	201543	0	None	-	1	Mouse	8.0	pEC50	=	8.0	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	378	11	3	4	3.6	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	118517485	142218	0	None	-3	4	Human	8.0	pEC50	=	8.0	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	CHEMBL3892492	142218	0	None	-3	4	Human	8.0	pEC50	=	8.0	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	71515515	150472	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	369	7	2	3	4.7	O=C(O)COc1cccc(NCc2cc(-c3cccc(F)c3)ccc2F)c1	nan
	CHEMBL3958411	150472	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	369	7	2	3	4.7	O=C(O)COc1cccc(NCc2cc(-c3cccc(F)c3)ccc2F)c1	nan
	126495427	138936	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	422	5	2	5	4.7	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4csc(C(=O)O)c4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794185	138936	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	422	5	2	5	4.7	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4csc(C(=O)O)c4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	11955193	143052	0	None	10	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	378	7	2	2	5.3	CC(C)(C)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3899346	143052	0	None	10	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	378	7	2	2	5.3	CC(C)(C)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	155550016	176108	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	13	2	6	3.6	O=C(O)CNc1cccc(CN(CCCCCc2ccccc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4539881	176108	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	13	2	6	3.6	O=C(O)CNc1cccc(CN(CCCCCc2ccccc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4598324	176108	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	13	2	6	3.6	O=C(O)CNc1cccc(CN(CCCCCc2ccccc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	53260150	175958	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	9	2	6	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(C(F)(F)F)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4451786	175958	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	9	2	6	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(C(F)(F)F)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597091	175958	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	9	2	6	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(C(F)(F)F)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	11855590	143841	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3905811	143841	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	11855591	143903	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	143903	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	11855591	143903	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	143903	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	118517360	143443	0	None	-61	3	Human	6.9	pEC50	=	6.9	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	412	8	2	3	4.7	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Cl)c2)cc1	nan
	CHEMBL3902700	143443	0	None	-61	3	Human	6.9	pEC50	=	6.9	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	412	8	2	3	4.7	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Cl)c2)cc1	nan
	118517489	143159	0	None	-18	3	Human	6.9	pEC50	=	6.9	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	CHEMBL3900245	143159	0	None	-18	3	Human	6.9	pEC50	=	6.9	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	11955257	153352	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	410	9	3	3	5.3	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3983069	153352	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	410	9	3	3	5.3	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	118352211	138855	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	375	5	2	6	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793209	138855	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	375	5	2	6	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3)O2)n1	10.1016/j.bmcl.2016.03.110
	118352211	138855	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	375	5	2	6	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3793209	138855	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	375	5	2	6	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	126495491	139695	0	None	28	4	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	429	8	2	6	4.5	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805169	139695	0	None	28	4	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	429	8	2	6	4.5	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	127050452	139714	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(C(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805408	139714	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(C(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	53260293	175639	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	11	2	6	4.2	CCC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CCC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4594090	175639	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	11	2	6	4.2	CCC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CCC1	10.1021/acs.jmedchem.8b00808
	89443700	152054	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1F	nan
	CHEMBL3971868	152054	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1F	nan
	89444072	148412	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1c(-c2cccc(F)c2)ccc(F)c1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	CHEMBL3941975	148412	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1c(-c2cccc(F)c2)ccc(F)c1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	44303952	100419	0	None	-	1	Mouse	6.9	pEC50	=	6.9	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	420	14	3	4	4.8	CCCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL293697	100419	0	None	-	1	Mouse	6.9	pEC50	=	6.9	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	420	14	3	4	4.8	CCCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	10270893	93793	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	376	12	2	4	3.1	CCCCCC(O)CCCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249954	93793	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	376	12	2	4	3.1	CCCCCC(O)CCCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	9885481	193713	0	None	14	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	365	16	2	4	3.0	CCCCCC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	CHEMBL551951	193713	0	None	14	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	365	16	2	4	3.0	CCCCCC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	11855325	144158	0	None	19	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144158	0	None	19	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855325	144158	0	None	19	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144158	0	None	19	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	127050451	139691	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(OC(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805122	139691	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(OC(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	89443781	148746	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	7	2	3	5.1	O=C(O)COc1ccc(F)c(NCc2cc(-c3ccc(F)c(F)c3)ccc2F)c1F	nan
	CHEMBL3944601	148746	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	7	2	3	5.1	O=C(O)COc1ccc(F)c(NCc2cc(-c3ccc(F)c(F)c3)ccc2F)c1F	nan
	10481859	74817	0	None	-67	2	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C	10.1016/j.bmc.2012.04.008
	CHEMBL2036321	74817	0	None	-67	2	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C	10.1016/j.bmc.2012.04.008
	44303627	201515	0	None	-	1	Mouse	5.9	pEC50	=	5.9	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	364	11	3	3	4.5	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64358	201515	0	None	-	1	Mouse	5.9	pEC50	=	5.9	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	364	11	3	3	4.5	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	134146425	148671	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	12	2	2	6.4	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3943966	148671	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	12	2	2	6.4	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	11855591	143903	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	143903	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	10291963	84284	0	None	-32	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL222715	84284	0	None	-32	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	127029402	138828	0	None	524	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	407	5	2	6	3.6	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)co4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793009	138828	0	None	524	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	407	5	2	6	3.6	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)co4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	24760052	150653	0	None	24	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3959769	150653	0	None	24	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	17751059	147736	0	None	3	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3936540	147736	0	None	3	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	89444124	142899	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1cc(-c2ccccc2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	CHEMBL3898152	142899	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1cc(-c2ccccc2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	156014791	177010	0	None	-309	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assayAgonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assay	ChEMBL	439	11	2	4	5.0	CCCCCC(O)CCc1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2020.127104
	CHEMBL4640635	177010	0	None	-309	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assayAgonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assay	ChEMBL	439	11	2	4	5.0	CCCCCC(O)CCc1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2020.127104
	57464006	74818	0	None	-288	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	534	10	2	7	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036322	74818	0	None	-288	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	534	10	2	7	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	10269242	155035	0	None	-54	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	348	9	2	4	2.2	CC(C)CC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL404413	155035	0	None	-54	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	348	9	2	4	2.2	CC(C)CC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	59465577	142657	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	13	2	2	6.8	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3896183	142657	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	13	2	2	6.8	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	59465570	142727	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	392	13	2	2	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3896693	142727	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	392	13	2	2	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)O)cc1	nan
	134143292	144695	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	12	1	3	6.5	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3912658	144695	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	12	1	3	6.5	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465574	145412	0	None	1	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	400	12	1	4	5.7	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)OC)cc1	nan
	CHEMBL3918084	145412	0	None	1	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	400	12	1	4	5.7	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)OC)cc1	nan
	59465601	149362	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.4	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3949271	149362	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.4	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	58681356	149838	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	434	7	3	4	3.9	O=C(O)COCC#CCC1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3953307	149838	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	434	7	3	4	3.9	O=C(O)COCC#CCC1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	44442327	94023	0	None	-891	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251294	94023	0	None	-891	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	11855870	145747	0	None	467	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	145747	0	None	467	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855870	145747	0	None	467	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	145747	0	None	467	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	71515516	147774	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	387	7	2	3	4.8	O=C(O)COc1ccc(F)c(NCc2cccc(-c3cccc(F)c3)c2)c1F	nan
	CHEMBL3936868	147774	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	387	7	2	3	4.8	O=C(O)COc1ccc(F)c(NCc2cccc(-c3cccc(F)c3)c2)c1F	nan
	71516448	152028	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	3	4	4.7	O=C(O)COc1ccc(F)c(NCc2cc(O)cc(-c3cccc(F)c3)c2F)c1F	nan
	CHEMBL3971730	152028	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	3	4	4.7	O=C(O)COc1ccc(F)c(NCc2cc(O)cc(-c3cccc(F)c3)c2F)c1F	nan
	57893848	74819	0	None	-724	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	535	10	2	8	4.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036323	74819	0	None	-724	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	535	10	2	8	4.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	118517488	153177	0	None	-14	3	Human	6.8	pEC50	=	6.8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	CHEMBL3981554	153177	0	None	-14	3	Human	6.8	pEC50	=	6.8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	58708286	153810	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	398	9	2	3	5.6	O=C(O)CCC/C=C\C[C@H]1C(=O)CC[C@@H]1c1ccc([C@H](O)C2CCCCC2)cc1	nan
	CHEMBL3986874	153810	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	398	9	2	3	5.6	O=C(O)CCC/C=C\C[C@H]1C(=O)CC[C@@H]1c1ccc([C@H](O)C2CCCCC2)cc1	nan
	1929	1575	46	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	9890801	1575	46	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	CHEMBL563646	1575	46	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	DB12022	1575	46	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	89444254	142248	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	7	2	3	5.1	O=C(O)COc1ccc(F)c(NCc2c(F)ccc(-c3cccc(F)c3)c2F)c1F	nan
	CHEMBL3892751	142248	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	7	2	3	5.1	O=C(O)COc1ccc(F)c(NCc2c(F)ccc(-c3cccc(F)c3)c2F)c1F	nan
	89443784	142374	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	431	8	2	4	5.2	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	CHEMBL3893770	142374	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	431	8	2	4	5.2	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	89444126	146855	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	403	7	3	4	4.6	O=C(O)COc1ccc(F)c(NCc2cc(O)cc(-c3cccc(F)c3)c2)c1F	nan
	CHEMBL3929662	146855	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	403	7	3	4	4.6	O=C(O)COc1ccc(F)c(NCc2cc(O)cc(-c3cccc(F)c3)c2)c1F	nan
	11955383	142001	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	358	7	2	3	4.2	CC(C)(C)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3890808	142001	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	358	7	2	3	4.2	CC(C)(C)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	53260155	170838	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	11	2	6	4.1	CC(C)C1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4462507	170838	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	11	2	6	4.1	CC(C)C1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	117703250	143107	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.5	C[C@@H](Nc1c(F)ccc(OCC(=O)O)c1F)c1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3899837	143107	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.5	C[C@@H](Nc1c(F)ccc(OCC(=O)O)c1F)c1cc(-c2cccc(F)c2)ccc1F	nan
	89444132	143334	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	417	8	2	4	4.9	COc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3901709	143334	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	417	8	2	4	4.9	COc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	89443635	151372	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(OCC(=O)O)c(C)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	CHEMBL3965998	151372	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(OCC(=O)O)c(C)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	57394893	70962	0	None	-223	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1957435	70962	0	None	-223	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.02.018
	10291963	84284	0	None	-3801	4	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmc.2012.02.018
	CHEMBL222715	84284	0	None	-3801	4	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmc.2012.02.018
	57394893	70962	0	None	-223	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL1957435	70962	0	None	-223	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.04.008
	11855867	145450	0	None	10	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	145450	0	None	10	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855867	145450	0	None	10	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	145450	0	None	10	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	44455115	95118	0	None	-6	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	387	10	2	3	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL257658	95118	0	None	-6	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	387	10	2	3	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	1883	3033	71	None	-2	10	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	1916	3033	71	None	-2	10	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	5280360	3033	71	None	-2	10	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	913	3033	71	None	-2	10	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	CHEMBL548	3033	71	None	-2	10	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	DB00917	3033	71	None	-2	10	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	53259985	175903	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	497	10	2	6	4.3	COc1ccc(S(=O)(=O)N(Cc2ccc(C(C)(C)C)cc2)Cc2cccc(NCC(=O)O)n2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4548451	175903	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	497	10	2	6	4.3	COc1ccc(S(=O)(=O)N(Cc2ccc(C(C)(C)C)cc2)Cc2cccc(NCC(=O)O)n2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596602	175903	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	497	10	2	6	4.3	COc1ccc(S(=O)(=O)N(Cc2ccc(C(C)(C)C)cc2)Cc2cccc(NCC(=O)O)n2)cc1	10.1021/acs.jmedchem.8b00808
	44442332	94091	0	None	-97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	341	9	1	2	4.2	CCCC/C=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251709	94091	0	None	-97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	341	9	1	2	4.2	CCCC/C=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	127026952	138831	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	451	6	2	6	4.9	CC(C)c1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793020	138831	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	451	6	2	6	4.9	CC(C)c1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	59465581	143580	0	None	22	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3903611	143580	0	None	22	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	145966519	163847	0	None	15	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	437	10	2	6	5.2	C[C@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CC1CCCC1	10.1016/j.bmc.2017.11.035
	CHEMBL4213312	163847	0	None	15	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	437	10	2	6	5.2	C[C@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CC1CCCC1	10.1016/j.bmc.2017.11.035
	44230429	175754	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	488	10	2	6	4.0	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4471378	175754	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	488	10	2	6	4.0	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595426	175754	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	488	10	2	6	4.0	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	89443841	145362	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	407	7	2	3	5.8	Cc1cc(-c2cccc(F)c2)cc(CNc2c(C)ccc(OCC(=O)O)c2C)c1C	nan
	CHEMBL3917749	145362	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	407	7	2	3	5.8	Cc1cc(-c2cccc(F)c2)cc(CNc2c(C)ccc(OCC(=O)O)c2C)c1C	nan
	89444231	145580	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	CHEMBL3919482	145580	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	89443843	148265	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	433	7	2	3	5.6	Cc1cc(-c2ccc(F)c(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	CHEMBL3940781	148265	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	433	7	2	3	5.6	Cc1cc(-c2ccc(F)c(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	89443583	149945	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2C)c1F	nan
	CHEMBL3954347	149945	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2C)c1F	nan
	66857988	163570	0	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	428	12	2	7	4.0	CCCCCC(C)(O)C/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4209929	163570	0	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	428	12	2	7	4.0	CCCCCC(C)(O)C/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	5283086	201619	19	None	-10	4	Mouse	8.7	pEC50	=	8.7	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	10.1016/s0960-894x(01)00359-6
	CHEMBL64804	201619	19	None	-10	4	Mouse	8.7	pEC50	=	8.7	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	10.1016/s0960-894x(01)00359-6
	118352285	138939	0	None	2398	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	406	5	2	5	4.2	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4ccc(C(=O)O)o4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794226	138939	0	None	2398	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	406	5	2	5	4.2	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4ccc(C(=O)O)o4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	18376196	193253	0	None	-	1	Rat	8.6	pEC50	=	8.6	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	466	9	1	4	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccn2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL541516	193253	0	None	-	1	Rat	8.6	pEC50	=	8.6	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	466	9	1	4	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccn2)cc1	10.1016/j.bmcl.2009.01.059
	70815687	175972	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	466	10	2	6	3.4	CC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4515583	175972	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	466	10	2	6	3.4	CC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597208	175972	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	466	10	2	6	3.4	CC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	138	3032	84	None	-1	9	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	1882	3032	84	None	-1	9	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	5280723	3032	84	None	-1	9	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	CHEMBL495	3032	84	None	-1	9	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	DB00770	3032	84	None	-1	9	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	53260134	175688	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4466224	175688	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4594970	175688	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.8b00808
	53259986	175946	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccn2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4442505	175946	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccn2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596979	175946	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccn2)cc1	10.1021/acs.jmedchem.8b00808
	53259987	175924	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4591201	175924	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596748	175924	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	9807448	201482	0	None	1	2	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64246	201482	0	None	1	2	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	118352215	138887	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	403	5	2	6	3.8	Cc1ccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc1C	10.1016/j.bmcl.2016.03.110
	CHEMBL3793797	138887	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	403	5	2	6	3.8	Cc1ccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc1C	10.1016/j.bmcl.2016.03.110
	11855865	152743	0	None	35	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	152743	0	None	35	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	10126807	193428	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	405	8	1	4	3.4	CC(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549869	193428	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	405	8	1	4	3.4	CC(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11955273	152255	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	438	10	3	4	4.6	O=C(O)COCCCC[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3973644	152255	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	438	10	3	4	4.6	O=C(O)COCCCC[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	138107701	186881	39	None	-1348	7	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	10.1016/j.ejmech.2022.114154
	5311181	186881	39	None	-1348	7	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	10.1016/j.ejmech.2022.114154
	CHEMBL494	186881	39	None	-1348	7	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	10.1016/j.ejmech.2022.114154
	59465583	142742	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	398	9	2	3	5.6	O=C(O)CCC/C=C\C[C@H]1C(=O)CC[C@@H]1c1ccc(C(O)C2CCCCC2)cc1	nan
	CHEMBL3896863	142742	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	398	9	2	3	5.6	O=C(O)CCC/C=C\C[C@H]1C(=O)CC[C@@H]1c1ccc(C(O)C2CCCCC2)cc1	nan
	11855594	152447	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	152447	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855594	152447	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	152447	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855871	145875	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	145875	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855871	145875	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	145875	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	54013831	145927	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3922151	145927	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	10363130	100566	0	None	-	1	Mouse	6.7	pEC50	=	6.7	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL294585	100566	0	None	-	1	Mouse	6.7	pEC50	=	6.7	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	9975502	94053	0	None	-14	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251504	94053	0	None	-14	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	24760052	150653	0	None	24	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3959769	150653	0	None	24	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	70667255	150942	0	None	24	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3962183	150942	0	None	24	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	72950089	150058	0	None	-4365	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL3955128	150058	0	None	-4365	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	11955180	151128	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	448	11	3	3	6.0	CCCC1(C(O)c2ccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3C/C=C\CCCC(=O)O)cc2)CCC1	nan
	CHEMBL3963968	151128	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	448	11	3	3	6.0	CCCC1(C(O)c2ccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3C/C=C\CCCC(=O)O)cc2)CCC1	nan
	10089562	153888	0	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL398948	153888	0	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	118352177	138882	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	6	1	6	4.8	CO[C@H]1C[C@@H]2O[C@@H](c3nc(C(=O)O)cs3)CC[C@@H]2[C@H]1COc1ccc(Cl)c(C)c1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793724	138882	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	6	1	6	4.8	CO[C@H]1C[C@@H]2O[C@@H](c3nc(C(=O)O)cs3)CC[C@@H]2[C@H]1COc1ccc(Cl)c(C)c1	10.1016/j.bmcl.2016.03.110
	127051064	139769	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3F)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806060	139769	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3F)O2)n1	10.1021/acsmedchemlett.5b00455
	89443417	151060	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2Cl)c1F	nan
	CHEMBL3963438	151060	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2Cl)c1F	nan
	44455046	95283	0	None	-8317	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	413	8	2	3	3.7	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL258332	95283	0	None	-8317	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	413	8	2	3	3.7	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.11.020
	56839536	142637	0	None	-141	7	Human	5.6	pEC50	=	5.6	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	604	15	2	7	5.1	CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1	nan
	CHEMBL3896035	142637	0	None	-141	7	Human	5.6	pEC50	=	5.6	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	604	15	2	7	5.1	CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1	nan
	57529188	146662	0	None	19	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	146662	0	None	19	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	89443813	151206	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3964577	151206	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	118517359	143863	0	None	-79	4	Human	7.6	pEC50	=	7.6	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	143863	0	None	-79	4	Human	7.6	pEC50	=	7.6	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	57384034	70963	0	None	-9	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1957436	70963	0	None	-9	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.02.018
	57384034	70963	0	None	-9	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL1957436	70963	0	None	-9	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.04.008
	11955194	150471	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	380	8	2	2	5.5	CC(C)(C)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3958410	150471	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	380	8	2	2	5.5	CC(C)(C)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	58708282	152590	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	412	11	2	3	6.0	CCCC1([C@@H](O)c2cccc([C@H]3CCC(=O)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	CHEMBL3976452	152590	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	412	11	2	3	6.0	CCCC1([C@@H](O)c2cccc([C@H]3CCC(=O)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	58681352	153805	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	486	10	3	4	5.5	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3Cc3cccc(OCC(=O)O)c3)c2)CCC1	nan
	CHEMBL3986829	153805	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	486	10	3	4	5.5	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3Cc3cccc(OCC(=O)O)c3)c2)CCC1	nan
	126495360	139704	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	5	2	6	3.4	Cc1ccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805316	139704	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	5	2	6	3.4	Cc1ccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc1	10.1021/acsmedchemlett.5b00455
	11855866	144069	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	144069	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	89443595	144428	5	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	412	7	2	4	4.7	N#Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3910551	144428	5	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	412	7	2	4	4.7	N#Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	57894053	74820	0	None	-208	2	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	551	10	2	8	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036324	74820	0	None	-208	2	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	551	10	2	8	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	118517359	143863	0	None	-79	4	Human	6.6	pEC50	=	6.6	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	143863	0	None	-79	4	Human	6.6	pEC50	=	6.6	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	126495420	139719	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	431	9	2	6	4.7	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCCCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805455	139719	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	431	9	2	6	4.7	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCCCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	11855324	142073	0	None	14	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142073	0	None	14	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	71515514	147093	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	405	7	2	3	5.0	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	CHEMBL3931335	147093	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	405	7	2	3	5.0	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	11955198	146710	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	436	10	3	3	5.8	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3928466	146710	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	436	10	3	3	5.8	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	155541719	175808	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	9	1	6	3.7	CN(CC(=O)O)c1cccc(CN(Cc2ccc(C(C)(C)C)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4519118	175808	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	9	1	6	3.7	CN(CC(=O)O)c1cccc(CN(Cc2ccc(C(C)(C)C)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595870	175808	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	9	1	6	3.7	CN(CC(=O)O)c1cccc(CN(Cc2ccc(C(C)(C)C)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	132836	59383	20	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL1722929	59383	20	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	155532079	171123	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	10	2	6	4.4	O=C(O)CNc1cccc(CN(Cc2ccc(C3CCCCC3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4466523	171123	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	10	2	6	4.4	O=C(O)CNc1cccc(CN(Cc2ccc(C3CCCCC3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	44455084	97418	0	None	-10	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	399	10	2	3	4.2	CCCCC1([C@@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.11.020
	CHEMBL272277	97418	0	None	-10	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	399	10	2	3	4.2	CCCCC1([C@@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.11.020
	59465581	143580	0	None	22	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3903611	143580	0	None	22	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	89443767	145179	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	409	8	2	4	5.2	COc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3916293	145179	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	409	8	2	4	5.2	COc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	89443716	146493	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3926711	146493	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	89443671	147305	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1c(F)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	CHEMBL3932999	147305	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1c(F)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	89445501	151744	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(-c2cccc(F)c2)cc(F)c1C	nan
	CHEMBL3969269	151744	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(-c2cccc(F)c2)cc(F)c1C	nan
	89443873	153406	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)c(F)c(-c2cccc(F)c2)c1	nan
	CHEMBL3983500	153406	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)c(F)c(-c2cccc(F)c2)c1	nan
	127051062	139744	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3Cl)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805767	139744	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3Cl)O2)n1	10.1021/acsmedchemlett.5b00455
	46931421	175689	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	7	3.6	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3s2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4476670	175689	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	7	3.6	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3s2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4594971	175689	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	7	3.6	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3s2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	126495424	139725	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	5	2	6	3.4	Cc1cccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)c1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805554	139725	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	5	2	6	3.4	Cc1cccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)c1	10.1021/acsmedchemlett.5b00455
	127052615	139740	0	None	181	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	401	6	2	6	3.7	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805693	139740	0	None	181	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	401	6	2	6	3.7	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	127027875	138886	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)cc3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793786	138886	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)cc3)O2)n1	10.1016/j.bmcl.2016.03.110
	127026954	138890	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	457	5	2	6	4.5	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1C(F)(F)F	10.1016/j.bmcl.2016.03.110
	CHEMBL3793809	138890	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	457	5	2	6	4.5	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1C(F)(F)F	10.1016/j.bmcl.2016.03.110
	127027875	138886	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3793786	138886	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	127052614	139696	0	None	40	6	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	415	7	2	6	4.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805176	139696	0	None	40	6	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	415	7	2	6	4.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	118517490	152621	0	None	-12	4	Human	7.5	pEC50	=	7.5	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	CHEMBL3976710	152621	0	None	-12	4	Human	7.5	pEC50	=	7.5	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	44230723	175931	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	490	10	2	8	2.8	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccnnc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4473407	175931	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	490	10	2	8	2.8	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccnnc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596867	175931	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	490	10	2	8	2.8	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccnnc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	134155748	150637	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959653	150637	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	145965248	163678	0	None	-9	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	439	10	2	6	5.4	CC(C)(C)CC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4211120	163678	0	None	-9	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	439	10	2	6	5.4	CC(C)(C)CC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	11855867	145450	0	None	10	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	145450	0	None	10	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	58681361	144148	0	None	-33	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	318	8	2	3	3.5	Cc1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3908432	144148	0	None	-33	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	318	8	2	3	3.5	Cc1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	44304181	201582	0	None	-1	2	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	394	13	3	4	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64663	201582	0	None	-1	2	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	394	13	3	4	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	58932683	74937	0	None	-1995	2	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	549	10	2	8	5.2	Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1	10.1016/j.bmc.2012.04.008
	CHEMBL2037289	74937	0	None	-1995	2	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	549	10	2	8	5.2	Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1	10.1016/j.bmc.2012.04.008
	11955178	153253	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	448	11	3	3	6.0	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	CHEMBL3982222	153253	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	448	11	3	3	6.0	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	44303980	167511	0	None	1	2	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration which increases intracellular c-AMP production in mouse EP2- receptorEffective concentration which increases intracellular c-AMP production in mouse EP2- receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL432522	167511	0	None	1	2	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration which increases intracellular c-AMP production in mouse EP2- receptorEffective concentration which increases intracellular c-AMP production in mouse EP2- receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/s0960-894x(01)00359-6
	1883	3033	71	None	-6	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	1916	3033	71	None	-6	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	5280360	3033	71	None	-6	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	913	3033	71	None	-6	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL548	3033	71	None	-6	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	DB00917	3033	71	None	-6	10	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	17757350	152222	0	None	870	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	CHEMBL3973347	152222	0	None	870	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	89444121	146899	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1Cl	nan
	CHEMBL3929987	146899	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1Cl	nan
	45271237	193429	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.0	CCCCc1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549870	193429	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.0	CCCCc1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	66858036	163339	0	None	-93	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	468	10	2	7	4.8	C[C@@H]1OC(=O)N(CCSc2nc(C(=O)O)cs2)[C@H]1/C=C/CC(C)(O)CC1CCCCC1	10.1016/j.bmc.2017.11.035
	CHEMBL4207054	163339	0	None	-93	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	468	10	2	7	4.8	C[C@@H]1OC(=O)N(CCSc2nc(C(=O)O)cs2)[C@H]1/C=C/CC(C)(O)CC1CCCCC1	10.1016/j.bmc.2017.11.035
	59465599	146028	0	None	1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	414	12	2	3	6.2	CCCC1(C(O)c2cccc([C@H]3CCC(=O)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	CHEMBL3922856	146028	0	None	1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	414	12	2	3	6.2	CCCC1(C(O)c2cccc([C@H]3CCC(=O)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	59465600	151166	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.3	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3964261	151166	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.3	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	58681358	150126	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	420	10	2	2	6.3	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(CC3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3955642	150126	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	420	10	2	2	6.3	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(CC3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	44442331	94054	0	None	-346	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251505	94054	0	None	-346	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	44230430	175796	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	506	10	2	6	4.2	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(F)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4449902	175796	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	506	10	2	6	4.2	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(F)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595790	175796	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	506	10	2	6	4.2	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(F)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	71515518	142274	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3892911	142274	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	89443584	144644	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2C)c(F)c(-c2cccc(F)c2)c1	nan
	CHEMBL3912323	144644	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2C)c(F)c(-c2cccc(F)c2)c1	nan
	118517361	152836	0	None	-107	3	Human	7.5	pEC50	=	7.5	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	CHEMBL3978590	152836	0	None	-107	3	Human	7.5	pEC50	=	7.5	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	155542681	176026	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	7	3.7	CC(C)(C)c1ccc(CN(Cc2csc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4521659	176026	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	7	3.7	CC(C)(C)c1ccc(CN(Cc2csc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597685	176026	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	7	3.7	CC(C)(C)c1ccc(CN(Cc2csc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	11955156	147922	0	None	-2	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	11	3	4	4.9	CCCC1(C(O)c2cccc([C@H]3[C@H](O)CC(=O)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	CHEMBL3937945	147922	0	None	-2	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	11	3	4	4.9	CCCC1(C(O)c2cccc([C@H]3[C@H](O)CC(=O)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	118689427	151320	0	None	-8	2	Human	7.4	pEC50	=	7.4	Functional	cAMP Assay: EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redundancies in function between EP2 and EP4 receptors. For example, both receptors induce PGE2-mediated RANKL through cAMP.cAMP Assay: EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redundancies in function between EP2 and EP4 receptors. For example, both receptors induce PGE2-mediated RANKL through cAMP.	ChEMBL	519	10	2	6	3.8	O=C(O)c1ccc(CCCN2[C@@H](/C=C/C(O)Cc3cccc(OC(F)(F)F)c3)CCS2(=O)=O)s1	nan
	CHEMBL3965497	151320	0	None	-8	2	Human	7.4	pEC50	=	7.4	Functional	cAMP Assay: EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redundancies in function between EP2 and EP4 receptors. For example, both receptors induce PGE2-mediated RANKL through cAMP.cAMP Assay: EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redundancies in function between EP2 and EP4 receptors. For example, both receptors induce PGE2-mediated RANKL through cAMP.	ChEMBL	519	10	2	6	3.8	O=C(O)c1ccc(CCCN2[C@@H](/C=C/C(O)Cc3cccc(OC(F)(F)F)c3)CCS2(=O)=O)s1	nan
	57893982	74814	0	None	-25	2	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	508	10	2	6	5.1	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	CHEMBL2036318	74814	0	None	-25	2	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	508	10	2	6	5.1	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	11955259	146226	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	436	9	3	4	4.4	O=C(O)COC/C=C\C[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3924405	146226	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	436	9	3	4	4.4	O=C(O)COC/C=C\C[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	57529188	146662	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	146662	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	57529188	146662	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	146662	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	44303626	167619	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL433249	167619	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	56839344	151519	0	None	-12882	8	Human	5.4	pEC50	=	5.4	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	656	13	2	9	5.1	O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F	nan
	CHEMBL3967284	151519	0	None	-12882	8	Human	5.4	pEC50	=	5.4	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	656	13	2	9	5.1	O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F	nan
	11955196	143889	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	434	9	3	3	5.6	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3906280	143889	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	434	9	3	3	5.6	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	44444722	93821	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	402	11	2	4	3.5	CCCC1(C(O)CCCN2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.09.074
	CHEMBL250153	93821	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	402	11	2	4	3.5	CCCC1(C(O)CCCN2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.09.074
	17751059	147736	0	None	3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3936540	147736	0	None	3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	17757350	152222	0	None	870	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	CHEMBL3973347	152222	0	None	870	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	89444221	143748	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	430	8	3	4	3.9	NC(=O)c1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3904996	143748	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	430	8	3	4	3.9	NC(=O)c1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	53259981	175776	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	467	9	2	5	4.3	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4456588	175776	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	467	9	2	5	4.3	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595646	175776	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	467	9	2	5	4.3	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.8b00808
	53259984	175961	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4447271	175961	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597100	175961	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00808
	53260154	170565	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	11	2	6	3.8	CCC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4458330	170565	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	11	2	6	3.8	CCC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	11955276	150218	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	358	7	3	4	2.9	O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc2c(c1)CCC2O	nan
	CHEMBL3956391	150218	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	358	7	3	4	2.9	O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc2c(c1)CCC2O	nan
	22246893	194278	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	371	13	1	4	2.7	CCCCc1ccc(CN(CCCCOCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559561	194278	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	371	13	1	4	2.7	CCCCc1ccc(CN(CCCCOCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11855588	146824	0	None	12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3929446	146824	0	None	12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	11855588	146824	0	None	12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3929446	146824	0	None	12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	22246765	193528	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	3.7	CCCCc1ccc(CN(CCc2ccc(CC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL550619	193528	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	3.7	CCCCc1ccc(CN(CCc2ccc(CC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	22246895	193891	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	399	14	2	4	3.7	CCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL554823	193891	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	399	14	2	4	3.7	CCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11855866	144069	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	144069	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855866	144069	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	144069	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	57564500	150678	0	None	2	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959926	150678	0	None	2	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	44230997	169969	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	479	10	2	9	1.9	O=C(O)CNc1cccc(CN(Cc2ccc(-n3cncn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4449855	169969	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	479	10	2	9	1.9	O=C(O)CNc1cccc(CN(Cc2ccc(-n3cncn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	44304199	100350	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2C/C=C/CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL293242	100350	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2C/C=C/CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	9821171	97417	0	None	-14454	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	379	8	2	3	3.1	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL272276	97417	0	None	-14454	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	379	8	2	3	3.1	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.11.020
	10223499	194667	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	413	15	2	4	4.1	CCCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL562411	194667	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	413	15	2	4	4.1	CCCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11855324	142073	0	None	14	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142073	0	None	14	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	11855324	142073	0	None	14	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142073	0	None	14	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	53259982	175861	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2F)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4561017	175861	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2F)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596258	175861	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2F)cc1	10.1021/acs.jmedchem.8b00808
	89443872	145308	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	437	7	2	3	6.0	O=C(O)COc1ccc(Cl)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1Cl	nan
	CHEMBL3917219	145308	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	437	7	2	3	6.0	O=C(O)COc1ccc(Cl)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1Cl	nan
	44304124	102150	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	12	3	4	4.3	CC(C)CC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL304225	102150	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	12	3	4	4.3	CC(C)CC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	11955297	149355	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	416	10	3	4	4.8	O=C(O)CCCCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc(C(O)C2CCCCC2)cc1	nan
	CHEMBL3949225	149355	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	416	10	3	4	4.8	O=C(O)CCCCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc(C(O)C2CCCCC2)cc1	nan
	22246983	194189	0	None	-	1	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	389	11	1	3	4.2	CS(=O)(=O)N(CCCCCCC(=O)O)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL558671	194189	0	None	-	1	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	389	11	1	3	4.2	CS(=O)(=O)N(CCCCCCC(=O)O)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	23729077	77841	22	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	520	11	0	8	4.0	CC(C)OC(=O)COc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)c1	nan
	CHEMBL2105692	77841	22	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	520	11	0	8	4.0	CC(C)OC(=O)COc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)c1	nan
	57894063	74815	0	None	-301	2	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	524	11	2	7	4.8	COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	CHEMBL2036319	74815	0	None	-301	2	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	524	11	2	7	4.8	COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	156010583	176504	0	None	-162	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assayAgonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assay	ChEMBL	451	10	2	4	5.4	CCCCCC(C)(O)/C=C/c1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2020.127104
	CHEMBL4633041	176504	0	None	-162	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assayAgonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assay	ChEMBL	451	10	2	4	5.4	CCCCCC(C)(O)/C=C/c1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2020.127104
	45271238	193968	0	None	-	1	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	8	1	3	4.0	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL556333	193968	0	None	-	1	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	8	1	3	4.0	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	59465587	144657	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	372	13	2	2	6.5	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)O)cc1	nan
	CHEMBL3912391	144657	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	372	13	2	2	6.5	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)O)cc1	nan
	11955315	143259	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	9	3	3	4.6	CC(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3901088	143259	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	9	3	3	4.6	CC(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	11955256	142784	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	424	9	2	4	5.4	COC(=O)CCCCCC[C@@H]1[C@@H](c2ccc(C(O)C(C)(C)C)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3897181	142784	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	424	9	2	4	5.4	COC(=O)CCCCCC[C@@H]1[C@@H](c2ccc(C(O)C(C)(C)C)cc2)[C@H](O)C[C@H]1Cl	nan
	16725337	149069	0	None	4	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	149069	0	None	4	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	16725337	149069	0	None	4	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	149069	0	None	4	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	89443809	147613	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	427	8	2	4	5.3	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1C	nan
	CHEMBL3935521	147613	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	427	8	2	4	5.3	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1C	nan
	89443631	148133	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1c(F)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1C	nan
	CHEMBL3939716	148133	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1c(F)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1C	nan
	127050450	139770	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806076	139770	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	57395059	69131	0	None	-11	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL1933725	69131	0	None	-11	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1021/acsmedchemlett.5b00455
	44229605	176080	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	452	9	2	7	3.1	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3o2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4470479	176080	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	452	9	2	7	3.1	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3o2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4598070	176080	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	452	9	2	7	3.1	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3o2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	89443989	148136	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(OCC(=O)O)c(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	CHEMBL3939740	148136	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(OCC(=O)O)c(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	44444714	93704	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	362	10	2	4	2.6	CCCC(C)C(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249341	93704	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	362	10	2	4	2.6	CCCC(C)C(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	59465588	142994	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	422	13	1	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3898887	142994	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	422	13	1	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465575	144534	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)c1	nan
	CHEMBL3911438	144534	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)c1	nan
	59465595	144890	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)c1	nan
	CHEMBL3914108	144890	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)c1	nan
	59465592	149170	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	386	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3947785	149170	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	386	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)OC)cc1	nan
	59465590	150412	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	406	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3957958	150412	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	406	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465584	150898	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	13	2	2	6.7	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCCO)cc1	nan
	CHEMBL3961847	150898	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	13	2	2	6.7	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCCO)cc1	nan
	11855325	144158	0	None	19	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144158	0	None	19	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11955233	145060	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	392	8	3	3	4.3	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C3(O)CCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3915426	145060	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	392	8	3	3	4.3	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C3(O)CCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	11855593	146301	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	425	11	2	4	4.7	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL3924987	146301	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	425	11	2	4	4.7	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2cccc(C(=O)O)c2)cc1	nan
	89444078	145541	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	405	7	2	3	5.0	O=C(O)COc1ccc(F)c(NCc2cc(F)cc(-c3cccc(F)c3)c2)c1F	nan
	CHEMBL3919144	145541	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	405	7	2	3	5.0	O=C(O)COc1ccc(F)c(NCc2cc(F)cc(-c3cccc(F)c3)c2)c1F	nan
	11955406	145571	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	376	10	3	4	3.4	CC(C)(CO)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3919393	145571	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	376	10	3	4	3.4	CC(C)(CO)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	11955294	144235	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	380	8	3	3	4.2	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3O)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3909111	144235	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	380	8	3	3	4.2	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3O)[C@H](O)C[C@H]1Cl	nan
	44303889	201526	0	None	-	1	Mouse	7.3	pEC50	=	7.3	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	414	10	3	4	4.2	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64423	201526	0	None	-	1	Mouse	7.3	pEC50	=	7.3	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	414	10	3	4	4.2	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/s0960-894x(01)00359-6
	11955179	145949	0	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	450	12	3	3	6.2	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	CHEMBL3922332	145949	0	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	450	12	3	3	6.2	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	11855588	146824	0	None	12	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3929446	146824	0	None	12	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	126495432	138794	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	406	5	2	5	4.2	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4coc(C(=O)O)c4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3792668	138794	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	406	5	2	5	4.2	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4coc(C(=O)O)c4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	71515517	147550	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)c(F)c(-c2cccc(F)c2)c1	nan
	CHEMBL3934986	147550	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)c(F)c(-c2cccc(F)c2)c1	nan
	56839343	143747	0	None	-147	6	Human	5.3	pEC50	=	5.3	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	642	14	2	8	5.4	COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1	nan
	CHEMBL3904989	143747	0	None	-147	6	Human	5.3	pEC50	=	5.3	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	642	14	2	8	5.4	COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1	nan
	45266955	193972	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	485	10	1	6	3.7	Cn1ccnc1CS(=O)(=O)N(Cc1ccc(C(C)(C)C)cc1)Cc1cccc(OCC(=O)O)c1	10.1016/j.bmcl.2009.01.059
	CHEMBL556416	193972	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	485	10	1	6	3.7	Cn1ccnc1CS(=O)(=O)N(Cc1ccc(C(C)(C)C)cc1)Cc1cccc(OCC(=O)O)c1	10.1016/j.bmcl.2009.01.059
	57564500	150678	0	None	2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959926	150678	0	None	2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	44303723	201246	0	None	-	1	Mouse	6.2	pEC50	=	6.2	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	12	3	4	4.4	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL62885	201246	0	None	-	1	Mouse	6.2	pEC50	=	6.2	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	12	3	4	4.4	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCC1	10.1016/s0960-894x(01)00359-6
	45269576	194309	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccc(CCCC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559820	194309	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccc(CCCC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	9863804	93664	0	None	-120	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	362	11	2	4	2.7	CCCCCC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249136	93664	0	None	-120	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	362	11	2	4	2.7	CCCCCC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	89444271	151376	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2C)c1C	nan
	CHEMBL3966050	151376	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2C)c1C	nan
	53259983	175727	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(F)c2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4587628	175727	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(F)c2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595199	175727	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(F)c2)cc1	10.1021/acs.jmedchem.8b00808
	2720	3793	55	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	5820	3793	55	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	6918140	3793	55	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	CHEMBL1237119	3793	55	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	DB00374	3793	55	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	127052577	139730	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(Cl)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805596	139730	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(Cl)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	67082722	164076	0	None	2	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCC[C@@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4216182	164076	0	None	2	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCC[C@@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	8541	2899	1	None	-66069	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	9824353	2899	1	None	-66069	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL292964	2899	1	None	-66069	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	155527947	175960	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4460294	175960	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597099	175960	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00808
	11955157	152111	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	430	12	3	4	5.1	CCCC1(C(O)c2cccc([C@H]3[C@H](O)CC(=O)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	CHEMBL3972401	152111	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	430	12	3	4	5.1	CCCC1(C(O)c2cccc([C@H]3[C@H](O)CC(=O)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	56649302	152134	0	None	-169	6	Human	5.2	pEC50	=	5.2	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	630	13	2	7	5.5	O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F	nan
	CHEMBL3972583	152134	0	None	-169	6	Human	5.2	pEC50	=	5.2	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	630	13	2	7	5.5	O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F	nan
	155539238	175907	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	6	4.0	CC(C)(C)C1CCC(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4514124	175907	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	6	4.0	CC(C)(C)C1CCC(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596631	175907	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	6	4.0	CC(C)(C)C1CCC(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)CC1	10.1021/acs.jmedchem.8b00808
	71516449	148904	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1ccc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	CHEMBL3945923	148904	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1ccc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	127050766	139683	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805075	139683	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	89443614	150056	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	393	7	2	3	5.5	Cc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3955120	150056	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	393	7	2	3	5.5	Cc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	127052613	139676	0	None	-10	6	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	431	7	3	7	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3804978	139676	0	None	-10	6	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	431	7	3	7	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	11955236	145923	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	396	10	3	3	4.5	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3922121	145923	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	396	10	3	3	4.5	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	44303711	101882	0	None	-	1	Mouse	7.2	pEC50	=	7.2	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	13	3	4	4.4	CCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL303763	101882	0	None	-	1	Mouse	7.2	pEC50	=	7.2	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	13	3	4	4.4	CCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	67245477	144350	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	13	1	4	7.0	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)s1	nan
	CHEMBL3909989	144350	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	13	1	4	7.0	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)s1	nan
	24760055	143356	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	CHEMBL3901873	143356	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	24760055	143356	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	CHEMBL3901873	143356	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	89443736	150822	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(Cl)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	CHEMBL3961188	150822	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(Cl)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	12521	2166	0	None	-23988	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	72722131	2166	0	None	-23988	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	CHEMBL3918816	2166	0	None	-23988	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	11955234	151685	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	9	3	3	4.6	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(C3(O)CCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3968751	151685	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	9	3	3	4.6	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(C3(O)CCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	44230431	176079	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	522	10	2	6	4.7	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(Cl)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4531171	176079	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	522	10	2	6	4.7	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(Cl)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4598069	176079	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	522	10	2	6	4.7	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(Cl)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	118517483	143739	0	None	-22	3	Human	7.1	pEC50	=	7.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	CHEMBL3904946	143739	0	None	-22	3	Human	7.1	pEC50	=	7.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	11855590	143841	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3905811	143841	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	11855590	143841	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3905811	143841	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	134147021	149492	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	414	13	2	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)s1	nan
	CHEMBL3950412	149492	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	414	13	2	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)s1	nan
	11955255	145724	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	8	3	3	5.0	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3920560	145724	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	8	3	3	5.0	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	92135977	152363	0	None	-141	4	Human	7.1	pEC50	=	7.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	CHEMBL3974652	152363	0	None	-141	4	Human	7.1	pEC50	=	7.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	5819	997	27	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at EP2 receptor (unknown origin) by cAMP assayAgonist activity at EP2 receptor (unknown origin) by cAMP assay	ChEMBL	333	4	1	5	4.0	CCOC(=O)c1c(sc2c1CCCCC2)NC(=O)c1ccco1	10.1021/jm401431x
	673766	997	27	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at EP2 receptor (unknown origin) by cAMP assayAgonist activity at EP2 receptor (unknown origin) by cAMP assay	ChEMBL	333	4	1	5	4.0	CCOC(=O)c1c(sc2c1CCCCC2)NC(=O)c1ccco1	10.1021/jm401431x
	CHEMBL1578948	997	27	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at EP2 receptor (unknown origin) by cAMP assayAgonist activity at EP2 receptor (unknown origin) by cAMP assay	ChEMBL	333	4	1	5	4.0	CCOC(=O)c1c(sc2c1CCCCC2)NC(=O)c1ccco1	10.1021/jm401431x
	11855871	145875	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	145875	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855594	152447	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	152447	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11502897	142261	0	None	43	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	142261	0	None	43	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11502897	142261	0	None	43	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	142261	0	None	43	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	89443779	148207	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	399	7	3	4	4.7	Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(O)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3940318	148207	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	399	7	3	4	4.7	Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(O)cc(-c2cccc(F)c2)c1	nan
	89443711	150447	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	433	7	2	3	5.6	Cc1cc(-c2cc(F)cc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	CHEMBL3958279	150447	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	433	7	2	3	5.6	Cc1cc(-c2cc(F)cc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	118517483	143739	0	None	-22	3	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	CHEMBL3904946	143739	0	None	-22	3	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	118517359	143863	0	None	-79	4	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	143863	0	None	-79	4	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	118517488	153177	0	None	-14	3	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	CHEMBL3981554	153177	0	None	-14	3	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	44442327	94023	0	None	-891	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL251294	94023	0	None	-891	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	11955358	152548	0	None	-11	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	364	8	2	2	4.7	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3976116	152548	0	None	-11	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	364	8	2	2	4.7	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3)[C@H](O)C[C@H]1Cl	nan
	155521507	175875	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	10	2	6	4.1	CC(C)(C)c1ccc(CN(Cc2cccc(NCCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4451941	175875	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	10	2	6	4.1	CC(C)(C)c1ccc(CN(Cc2cccc(NCCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596396	175875	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	10	2	6	4.1	CC(C)(C)c1ccc(CN(Cc2cccc(NCCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	56839342	148475	0	None	-83	7	Human	6.1	pEC50	=	6.1	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	646	13	2	7	6.0	O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F	nan
	CHEMBL3942394	148475	0	None	-83	7	Human	6.1	pEC50	=	6.1	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	646	13	2	7	6.0	O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F	nan
	58932678	74938	0	None	-301	2	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	549	10	2	8	5.2	Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12	10.1016/j.bmc.2012.04.008
	CHEMBL2037290	74938	0	None	-301	2	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	549	10	2	8	5.2	Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12	10.1016/j.bmc.2012.04.008
	22246956	194645	0	None	-	1	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	411	15	1	4	4.2	CCCCCC(=O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL562291	194645	0	None	-	1	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	411	15	1	4	4.2	CCCCCC(=O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	69753740	139692	0	None	-2454	5	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	390	9	3	5	2.8	O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805134	139692	0	None	-2454	5	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	390	9	3	5	2.8	O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1	10.1021/acsmedchemlett.5b00455
	134155748	150637	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959653	150637	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	89443669	146679	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	417	7	3	4	4.9	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1O	nan
	CHEMBL3928263	146679	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	417	7	3	4	4.9	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1O	nan
	89443662	152355	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	412	7	2	4	4.7	N#Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3974557	152355	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	412	7	2	4	4.7	N#Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	1883	3033	71	None	-6	10	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	1916	3033	71	None	-6	10	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	5280360	3033	71	None	-6	10	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	913	3033	71	None	-6	10	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL548	3033	71	None	-6	10	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	DB00917	3033	71	None	-6	10	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	56835070	69128	0	None	-112	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933722	69128	0	None	-112	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	56835070	69128	0	None	-112	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL1933722	69128	0	None	-112	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.04.008
	51036042	175767	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	405	8	2	5	2.8	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(C)(=O)=O)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4554216	175767	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	405	8	2	5	2.8	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(C)(=O)=O)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595541	175767	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	405	8	2	5	2.8	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(C)(=O)=O)cc1	10.1021/acs.jmedchem.8b00808
	66857975	163936	0	None	-10	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	454	10	2	7	4.4	CC(O)(C/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1)CC1CCCCC1	10.1016/j.bmc.2017.11.035
	CHEMBL4214346	163936	0	None	-10	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	454	10	2	7	4.4	CC(O)(C/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1)CC1CCCCC1	10.1016/j.bmc.2017.11.035
	11955133	145116	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	374	8	1	4	4.5	COC(=O)CCCCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc(C(C)(C)C)cc1	nan
	CHEMBL3915820	145116	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	374	8	1	4	4.5	COC(=O)CCCCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc(C(C)(C)C)cc1	nan
	9820676	193375	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	369	13	1	3	3.8	CCCCc1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549461	193375	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	369	13	1	3	3.8	CCCCc1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	89444029	148562	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1ccc(OCC(=O)O)c(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3943109	148562	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1ccc(OCC(=O)O)c(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	122180297	121133	0	None	4466	2	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	437	3	1	4	4.9	C[C@@H]1COc2c(Cl)cc(-n3ccc4cc(F)ccc43)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586362	121133	0	None	4466	2	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	437	3	1	4	4.9	C[C@@H]1COc2c(Cl)cc(-n3ccc4cc(F)ccc43)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	122180261	121099	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(C#N)c1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586324	121099	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(C#N)c1)C2	10.1021/acs.jmedchem.5b00567
	122180274	121109	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	385	4	0	5	4.4	COc1cc(-n2ccc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586337	121109	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	385	4	0	5	4.4	COc1cc(-n2ccc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180288	121124	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	386	3	0	4	5.7	Cc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586352	121124	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	386	3	0	4	5.7	Cc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180250	121088	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	432	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1OC)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586313	121088	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	432	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1OC)C2	10.1021/acs.jmedchem.5b00567
	122180267	121103	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	360	4	0	4	4.5	COc1cc(-c2cccc(C)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586330	121103	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	360	4	0	4	4.5	COc1cc(-c2cccc(C)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180251	121089	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	432	5	0	6	5.4	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cn1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586314	121089	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	432	5	0	6	5.4	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cn1	10.1021/acs.jmedchem.5b00567
	122180273	121108	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	386	4	0	6	3.8	COc1cc(-n2cnc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586336	121108	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	386	4	0	6	3.8	COc1cc(-n2cnc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	1987175	3735	24	None	1	5	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assayAntagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assay	ChEMBL	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	10.1021/ml400112h
	9283	3735	24	None	1	5	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assayAntagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assay	ChEMBL	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	10.1021/ml400112h
	CHEMBL1372836	3735	24	None	1	5	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assayAntagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assay	ChEMBL	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	10.1021/ml400112h
	122180270	121105	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	380	4	0	4	4.8	COc1cc(-c2cccc(Cl)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586333	121105	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	380	4	0	4	4.8	COc1cc(-c2cccc(Cl)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180282	121117	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	410	4	0	6	4.3	COc1cc(-n2ccc3cc(C#N)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586345	121117	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	410	4	0	6	4.3	COc1cc(-n2ccc3cc(C#N)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180295	121130	0	None	281	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	422	3	1	4	5.3	O=c1cc(CN2CCOc3c(Cl)cc(-c4csc5ccccc45)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586359	121130	0	None	281	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	422	3	1	4	5.3	O=c1cc(CN2CCOc3c(Cl)cc(-c4csc5ccccc45)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	122180296	121132	0	None	758	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	436	3	1	4	5.7	C[C@@H]1COc2c(Cl)cc(-c3csc4ccccc34)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586361	121132	0	None	758	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	436	3	1	4	5.7	C[C@@H]1COc2c(Cl)cc(-c3csc4ccccc34)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	122180265	121102	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	396	4	0	4	5.3	COc1cc(-c2cccc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586328	121102	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	396	4	0	4	5.3	COc1cc(-c2cccc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180276	121111	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	399	4	0	5	4.6	COc1cc(-c2cn(C)c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586339	121111	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	399	4	0	5	4.6	COc1cc(-c2cn(C)c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180289	121125	0	None	7	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	406	3	0	4	6.0	Clc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586353	121125	0	None	7	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	406	3	0	4	6.0	Clc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	56927669	121131	0	None	-2	4	Rat	7.5	pIC50	=	7.5	Functional	Antagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	121131	0	None	-2	4	Rat	7.5	pIC50	=	7.5	Functional	Antagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	30897313	121084	0	None	-2	5	Rat	6.5	pIC50	=	6.5	Functional	Antagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	121084	0	None	-2	5	Rat	6.5	pIC50	=	6.5	Functional	Antagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	42484632	121085	5	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccn1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586310	121085	5	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccn1)C2	10.1021/acs.jmedchem.5b00567
	122180275	121110	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	385	4	1	4	4.6	COc1cc(-c2c[nH]c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586338	121110	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	385	4	1	4	4.6	COc1cc(-c2c[nH]c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180278	121113	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3c(Cl)cccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586341	121113	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3c(Cl)cccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180286	121121	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	388	3	1	5	5.1	Oc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586349	121121	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	388	3	1	5	5.1	Oc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	56927669	121131	0	None	2	4	Mouse	8.4	pIC50	=	8.4	Functional	Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	121131	0	None	2	4	Mouse	8.4	pIC50	=	8.4	Functional	Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	122180283	121118	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	5	4.6	COc1cc(-n2ccc3cc(F)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586346	121118	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	5	4.6	COc1cc(-n2ccc3cc(F)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180280	121115	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3ccc(Cl)cc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586343	121115	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3ccc(Cl)cc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180263	121100	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2cc3ccccc3s2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586326	121100	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2cc3ccccc3s2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	56927669	121131	0	None	-3	4	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	121131	0	None	-3	4	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	122180252	121090	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	418	4	1	5	4.7	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(=O)[nH]c1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586315	121090	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	418	4	1	5	4.7	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(=O)[nH]c1)C2	10.1021/acs.jmedchem.5b00567
	122180284	121119	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	421	4	0	5	4.8	COc1cc(N2CCc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586347	121119	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	421	4	0	5	4.8	COc1cc(N2CCc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	30897313	121084	0	None	2	5	Mouse	7.2	pIC50	=	7.2	Functional	Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	121084	0	None	2	5	Mouse	7.2	pIC50	=	7.2	Functional	Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	30897313	121084	0	None	-2	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	121084	0	None	-2	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180272	121107	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	6	4.8	COc1cc(-c2nsc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586335	121107	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	6	4.8	COc1cc(-c2nsc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180279	121114	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586342	121114	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180249	121087	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	6	4.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cncnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586312	121087	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	6	4.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cncnc1)C2	10.1021/acs.jmedchem.5b00567
	30956824	121086	3	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccncc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586311	121086	3	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccncc1)C2	10.1021/acs.jmedchem.5b00567
	122180277	121112	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2cc(Cl)c3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586340	121112	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2cc(Cl)c3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	44365207	40455	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	489	5	2	6	3.8	O=C(CCS(=O)(=O)Cc1ccco1)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	CHEMBL148449	40455	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	489	5	2	6	3.8	O=C(CCS(=O)(=O)Cc1ccco1)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	38191	9820	15	None	-	0	Human	6.2	pKd	=	6.2	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	407	4	2	3	4.6	O=C(CCCCCl)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	CHEMBL114395	9820	15	None	-	0	Human	6.2	pKd	=	6.2	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	407	4	2	3	4.6	O=C(CCCCCl)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	44365227	121472	0	None	-	0	Human	6.2	pKd	=	6.2	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	473	5	2	5	4.1	O=C(CC[S+]([O-])Cc1ccco1)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	CHEMBL359231	121472	0	None	-	0	Human	6.2	pKd	=	6.2	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	473	5	2	5	4.1	O=C(CC[S+]([O-])Cc1ccco1)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	1924	3486	33	None	-	0	Human	8.1	pKd	=	8.1	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	457	5	2	5	5.1	O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCSCc1ccco1	10.1016/0960-894X(94)80027-8
	9933831	3486	33	None	-	0	Human	8.1	pKd	=	8.1	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	457	5	2	5	5.1	O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCSCc1ccco1	10.1016/0960-894X(94)80027-8
	CHEMBL358653	3486	33	None	-	0	Human	8.1	pKd	=	8.1	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	457	5	2	5	5.1	O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCSCc1ccco1	10.1016/0960-894X(94)80027-8
	119461	317	66	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at EP2 receptor (unknown origin) by functional cAMP assayAntagonist activity at EP2 receptor (unknown origin) by functional cAMP assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	1896	317	66	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at EP2 receptor (unknown origin) by functional cAMP assayAntagonist activity at EP2 receptor (unknown origin) by functional cAMP assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	CHEMBL1317823	317	66	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at EP2 receptor (unknown origin) by functional cAMP assayAntagonist activity at EP2 receptor (unknown origin) by functional cAMP assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	9817405	164851	2	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	288	4	1	1	4.5	O=C(O)/C=C/c1ccccc1Cc1ccc2ccccc2c1	10.1016/s0960-894x(01)00056-7
	CHEMBL423815	164851	2	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	288	4	1	1	4.5	O=C(O)/C=C/c1ccccc1Cc1ccc2ccccc2c1	10.1016/s0960-894x(01)00056-7
	10402929	57239	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	306	4	1	1	4.7	O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00056-7
	CHEMBL166351	57239	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	306	4	1	1	4.7	O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00056-7
	44377464	119580	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	306	4	1	1	4.7	O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)cc1Cl	10.1016/s0960-894x(01)00056-7
	CHEMBL350832	119580	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	306	4	1	1	4.7	O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)cc1Cl	10.1016/s0960-894x(01)00056-7
	9817292	56931	0	None	-	0	Human	4.4	pKi	=	4.4	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	284	5	1	2	4.1	CSc1ccc(Cc2ccccc2/C=C/C(=O)O)cc1	10.1016/s0960-894x(01)00056-7
	CHEMBL165010	56931	0	None	-	0	Human	4.4	pKi	=	4.4	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	284	5	1	2	4.1	CSc1ccc(Cc2ccccc2/C=C/C(=O)O)cc1	10.1016/s0960-894x(01)00056-7
	10483360	197549	21	None	-	4	Human	4.4	pKi	=	4.4	Functional	Inhibition of EP2 expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP productionInhibition of EP2 expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP production	ChEMBL	580	12	3	6	5.8	CCCCNC(=O)c1ccc(Oc2ccc(CC(=O)O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1	10.1016/j.bmcl.2009.09.052
	CHEMBL589973	197549	21	None	-	4	Human	4.4	pKi	=	4.4	Functional	Inhibition of EP2 expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP productionInhibition of EP2 expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP production	ChEMBL	580	12	3	6	5.8	CCCCNC(=O)c1ccc(Oc2ccc(CC(=O)O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1	10.1016/j.bmcl.2009.09.052
	138	3032	84	None	-4	9	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	1882	3032	84	None	-4	9	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	5280723	3032	84	None	-4	9	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	CHEMBL495	3032	84	None	-4	9	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	DB00770	3032	84	None	-4	9	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	44230999	166886	20	None	-	1	Human	8.1	pEC50	=	8.1	Functional	activity measured for the active metabolite (omidenepag)activity measured for the active metabolite (omidenepag)	Drug Central	520	11	1	9	3.4	CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1	None
	CHEMBL4297666	166886	20	None	-	1	Human	8.1	pEC50	=	8.1	Functional	activity measured for the active metabolite (omidenepag)activity measured for the active metabolite (omidenepag)	Drug Central	520	11	1	9	3.4	CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1	None
	1929	1575	46	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	9890801	1575	46	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	CHEMBL563646	1575	46	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	DB12022	1575	46	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	1883	3033	71	None	-2	10	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1916	3033	71	None	-2	10	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	5280360	3033	71	None	-2	10	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	913	3033	71	None	-2	10	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	CHEMBL548	3033	71	None	-2	10	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	DB00917	3033	71	None	-2	10	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1929	1575	46	None	2	2	Rat	7.3	pIC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	9890801	1575	46	None	2	2	Rat	7.3	pIC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	CHEMBL563646	1575	46	None	2	2	Rat	7.3	pIC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	DB12022	1575	46	None	2	2	Rat	7.3	pIC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	18376177	3696	45	None	-1	2	Human	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	5816	3696	45	None	-1	2	Human	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	CHEMBL2107783	3696	45	None	-1	2	Human	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	DB12623	3696	45	None	-1	2	Human	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	18376177	3696	45	None	1	2	Rat	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	5816	3696	45	None	1	2	Rat	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	CHEMBL2107783	3696	45	None	1	2	Rat	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	DB12623	3696	45	None	1	2	Rat	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	12520	3737	0	None	-	1	Human	7.9	pKB	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	344	5	3	2	3.8	CC1=C(CCNC(=O)C2=CC=C(C=C2)C3=CNC=N3)C4=C(N1)C=CC=C4	35187419
	12520	3737	0	None	-	1	Human	7.9	pKB	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	344	5	3	2	3.8	CC1=C(CCNC(=O)C2=CC=C(C=C2)C3=CNC=N3)C4=C(N1)C=CC=C4	36654746
	155128767	3737	0	None	-	1	Human	7.9	pKB	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	344	5	3	2	3.8	CC1=C(CCNC(=O)C2=CC=C(C=C2)C3=CNC=N3)C4=C(N1)C=CC=C4	35187419
	155128767	3737	0	None	-	1	Human	7.9	pKB	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	344	5	3	2	3.8	CC1=C(CCNC(=O)C2=CC=C(C=C2)C3=CNC=N3)C4=C(N1)C=CC=C4	36654746
	10603	3733	0	None	537	3	Human	8.0	pKB	=	8.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	400	6	3	5	4.0	Cc1cc(Nc2ncc(cn2)C(=O)NCCc2c(C)[nH]c3c2cccc3)nc(c1)C	31904232
	145996528	3733	0	None	537	3	Human	8.0	pKB	=	8.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	400	6	3	5	4.0	Cc1cc(Nc2ncc(cn2)C(=O)NCCc2c(C)[nH]c3c2cccc3)nc(c1)C	31904232
	CHEMBL4552900	3733	0	None	537	3	Human	8.0	pKB	=	8.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	400	6	3	5	4.0	Cc1cc(Nc2ncc(cn2)C(=O)NCCc2c(C)[nH]c3c2cccc3)nc(c1)C	31904232
	1987175	3735	24	None	1	5	Human	8.1	pKB	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	23914286
	9283	3735	24	None	1	5	Human	8.1	pKB	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	23914286
	CHEMBL1372836	3735	24	None	1	5	Human	8.1	pKB	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	23914286
	25114442	3012	49	None	-1	2	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	21595651
	25114442	3012	49	None	-1	2	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	5817	3012	49	None	-1	2	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	21595651
	5817	3012	49	None	-1	2	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	CHEMBL3286797	3012	49	None	-1	2	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	21595651
	CHEMBL3286797	3012	49	None	-1	2	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	DB12024	3012	49	None	-1	2	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	21595651
	DB12024	3012	49	None	-1	2	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	25114442	3012	49	None	1	2	Mouse	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	5817	3012	49	None	1	2	Mouse	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	CHEMBL3286797	3012	49	None	1	2	Mouse	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	DB12024	3012	49	None	1	2	Mouse	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	46213069	3014	0	None	-	1	Human	8.5	pKB	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	456	7	1	5	4.2	COc1ccc(cc1)C(=O)N1CCC(C1)(COc1ccc(cc1)c1ccc(cc1)C#N)C(=O)O	23786281
	8538	3014	0	None	-	1	Human	8.5	pKB	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	456	7	1	5	4.2	COc1ccc(cc1)C(=O)N1CCC(C1)(COc1ccc(cc1)c1ccc(cc1)C#N)C(=O)O	23786281
	8546	3736	0	None	-	1	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	377	9	1	3	4.5	CCN(c1ccc(cc1)CC(=O)NCCCn1c(C)cc2c1cccc2)CC	24937185
	91827368	3736	0	None	-	1	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	377	9	1	3	4.5	CCN(c1ccc(cc1)CC(=O)NCCCn1c(C)cc2c1cccc2)CC	24937185
	5818	3734	42	None	1096	2	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	22323596
	5886965	3734	42	None	1096	2	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	22323596
	CHEMBL1368005	3734	42	None	1096	2	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	22323596

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	11855868	152012	0	None	-	1	Human	9.8	pEC50	=	9.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	152012	0	None	-	1	Human	9.8	pEC50	=	9.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	127037150	137035	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	426	12	2	6	4.1	CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	CHEMBL3754586	137035	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	426	12	2	6	4.1	CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	16725337	149069	0	None	-	1	Human	9.2	pEC50	=	9.2	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	149069	0	None	-	1	Human	9.2	pEC50	=	9.2	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	59554827	136769	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	426	11	2	6	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	CHEMBL3752377	136769	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	426	11	2	6	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	11502897	142261	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	142261	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855865	152743	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	152743	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855870	145747	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	145747	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	1932	2897	4	None	1	6	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
	5311228	2897	4	None	1	6	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
	CHEMBL3286796	2897	4	None	1	6	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
	90054482	143385	0	None	-	0	Human	6.0	pEC50	=	6	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	463	10	2	4	4.4	C[C@@H](Cc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3902065	143385	0	None	-	0	Human	6.0	pEC50	=	6	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	463	10	2	4	4.4	C[C@@H](Cc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	90054490	151658	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	519	14	2	4	6.0	C[C@@H](CCCCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3968443	151658	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	519	14	2	4	6.0	C[C@@H](CCCCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	127051063	139792	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3C(F)(F)F)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806284	139792	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3C(F)(F)F)O2)n1	10.1021/acsmedchemlett.5b00455
	11855590	143841	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3905811	143841	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	90054450	143244	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	493	13	2	4	5.4	C[C@@H](CCCc1ccccc1)[C@H](O)CC[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3900979	143244	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	493	13	2	4	5.4	C[C@@H](CCCc1ccccc1)[C@H](O)CC[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	11855591	143903	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	143903	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	72948479	152499	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	491	12	2	4	5.2	C[C@@H](CCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3975743	152499	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	491	12	2	4	5.2	C[C@@H](CCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	70667255	150942	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3962183	150942	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	90054430	148832	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	505	13	2	4	5.6	C[C@@H](CCCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3945327	148832	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	505	13	2	4	5.6	C[C@@H](CCCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	5283056	201172	26	None	-	0	Human	7.8	pEC50	=	7.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O	nan
	CHEMBL62570	201172	26	None	-	0	Human	7.8	pEC50	=	7.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O	nan
	66858111	136926	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	488	11	2	7	4.5	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCc3ccccc3)CCC2)n1	10.1016/j.bmcl.2015.12.039
	CHEMBL3753622	136926	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	488	11	2	7	4.5	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCc3ccccc3)CCC2)n1	10.1016/j.bmcl.2015.12.039
	72950425	142518	0	None	-	1	Human	5.8	pEC50	=	5.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	419	8	2	3	3.5	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCc1ccc(C(=O)O)cc1	nan
	CHEMBL3895047	142518	0	None	-	1	Human	5.8	pEC50	=	5.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	419	8	2	3	3.5	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCc1ccc(C(=O)O)cc1	nan
	11328569	136943	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	456	12	2	8	3.3	COCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	CHEMBL3753788	136943	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	456	12	2	8	3.3	COCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	11855324	142073	0	None	-	1	Human	6.7	pEC50	=	6.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142073	0	None	-	1	Human	6.7	pEC50	=	6.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	72950929	146049	0	None	-	1	Human	5.7	pEC50	=	5.7	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	395	10	2	3	3.7	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCc1ccc(C(=O)O)cc1	nan
	CHEMBL3923027	146049	0	None	-	1	Human	5.7	pEC50	=	5.7	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	395	10	2	3	3.7	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCc1ccc(C(=O)O)cc1	nan
	1883	3033	71	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	1916	3033	71	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	5280360	3033	71	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	913	3033	71	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	CHEMBL548	3033	71	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	DB00917	3033	71	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	126495400	138791	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3792632	138791	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	127026955	138920	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	437	5	2	6	4.4	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc(C)c1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794016	138920	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	437	5	2	6	4.4	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc(C)c1Cl	10.1016/j.bmcl.2016.03.110
	18376177	3696	45	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	5816	3696	45	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	CHEMBL2107783	3696	45	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	DB12623	3696	45	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	11294085	136728	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	458	12	2	7	4.0	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCCCF)CCC2)n1	10.1016/j.bmcl.2015.12.039
	CHEMBL3751951	136728	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	458	12	2	7	4.0	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCCCF)CCC2)n1	10.1016/j.bmcl.2015.12.039
	59554822	136869	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	440	11	2	7	4.0	CCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	CHEMBL3753221	136869	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	440	11	2	7	4.0	CCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	127051062	139744	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3Cl)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805767	139744	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3Cl)O2)n1	10.1021/acsmedchemlett.5b00455
	72950089	150058	0	None	-1621	3	Human	6.7	pEC50	=	6.7	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	nan
	CHEMBL3955128	150058	0	None	-1621	3	Human	6.7	pEC50	=	6.7	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	nan
	66857670	136876	0	None	-	1	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	436	9	2	7	3.3	CC#CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	CHEMBL3753268	136876	0	None	-	1	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	436	9	2	7	3.3	CC#CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	57529188	146662	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	146662	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	11855866	144069	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	144069	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855325	144158	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144158	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855324	142073	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142073	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	127026652	136957	0	None	-	1	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	456	12	2	8	3.3	CCOCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	CHEMBL3753898	136957	0	None	-	1	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	456	12	2	8	3.3	CCOCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	127026956	138896	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cc(Cl)c(Cl)cc3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793862	138896	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cc(Cl)c(Cl)cc3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	9807448	201482	0	None	1	4	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1021/jm401431x
	CHEMBL64246	201482	0	None	1	4	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1021/jm401431x
	11855867	145450	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	145450	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	1892	736	15	None	-2	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
	25886893	736	15	None	-2	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
	CHEMBL1628262	736	15	None	-2	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
	72948663	145201	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	415	11	2	4	4.1	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3916499	145201	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	415	11	2	4	4.1	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	5311035	97354	27	None	-4	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1021/jm401431x
	CHEMBL271896	97354	27	None	-4	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1021/jm401431x
	1883	3033	71	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	1916	3033	71	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	5280360	3033	71	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	913	3033	71	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	CHEMBL548	3033	71	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	DB00917	3033	71	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	66857738	136776	0	None	-	1	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	468	10	2	7	4.7	CC(C)(C)CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	CHEMBL3752435	136776	0	None	-	1	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	468	10	2	7	4.7	CC(C)(C)CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
	127050451	139691	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(OC(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805122	139691	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(OC(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	1929	1575	46	None	-11	2	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	9890801	1575	46	None	-11	2	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	CHEMBL563646	1575	46	None	-11	2	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	DB12022	1575	46	None	-11	2	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	11362836	136772	0	None	-	1	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	446	12	2	7	3.8	CC(C)(CCCCF)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	CHEMBL3752406	136772	0	None	-	1	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	446	12	2	7	3.8	CC(C)(CCCCF)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	11855325	144158	0	None	-	1	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144158	0	None	-	1	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855593	146301	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	425	11	2	4	4.7	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL3924987	146301	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	425	11	2	4	4.7	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2cccc(C(=O)O)c2)cc1	nan
	11855588	146824	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3929446	146824	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	5283086	201619	19	None	-	5	Human	7.2	pEC50	=	7.2	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
	CHEMBL64804	201619	19	None	-	5	Human	7.2	pEC50	=	7.2	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
	11156167	136995	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	494	11	2	7	5.2	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCC3CCCCC3)CCC2)n1	10.1016/j.bmcl.2015.12.039
	CHEMBL3754197	136995	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	494	11	2	7	5.2	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCC3CCCCC3)CCC2)n1	10.1016/j.bmcl.2015.12.039
	90054537	147871	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	491	12	2	4	5.2	C[C@@H](CCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3937596	147871	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	491	12	2	4	5.2	C[C@@H](CCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	127051656	139764	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(OC(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805981	139764	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(OC(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	59554824	136950	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	428	11	2	7	3.9	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	CHEMBL3753853	136950	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	428	11	2	7	3.9	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
	90054519	151454	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	477	11	2	4	4.8	C[C@@H](CCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3966743	151454	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	477	11	2	4	4.8	C[C@@H](CCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	72948294	149425	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	439	9	2	4	4.0	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3949856	149425	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	439	9	2	4	4.0	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	90054392	142386	0	None	-	0	Human	4.1	pEC50	=	4.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	519	14	2	4	6.0	C[C@@H](CCCCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	CHEMBL3893847	142386	0	None	-	0	Human	4.1	pEC50	=	4.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	519	14	2	4	6.0	C[C@@H](CCCCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
	11855871	145875	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	145875	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855594	152447	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	152447	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	127027874	138833	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3793045	138833	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	127027874	138833	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793045	138833	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	10339756	142553	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.	ChEMBL	380	12	3	4	3.9	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
	CHEMBL3895324	142553	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.	ChEMBL	380	12	3	4	3.9	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
	118689427	151320	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10N HCl is added to achieve a pH of 7.4). The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 °C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H−] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations were for 60 min at 25 °C. and were terminated by the addition of 4 ml of ice-cold 50 mM TRIS-HCl, followed by rapid filtration through Whatman GF/B filters and three additional 4 ml washes in a cell harvester (Brandel). Competition studies were performed using a final concentration of 5 nM [3H]-PGE2, or 5 nM [3H] 17-phenyl PGF2a and non-specific binding determined with 10^−5M of unlabeled PGE2, or 17-phenyl PGF2a, according to receptor subtype studied.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10N HCl is added to achieve a pH of 7.4). The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 °C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H−] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations were for 60 min at 25 °C. and were terminated by the addition of 4 ml of ice-cold 50 mM TRIS-HCl, followed by rapid filtration through Whatman GF/B filters and three additional 4 ml washes in a cell harvester (Brandel). Competition studies were performed using a final concentration of 5 nM [3H]-PGE2, or 5 nM [3H] 17-phenyl PGF2a and non-specific binding determined with 10^−5M of unlabeled PGE2, or 17-phenyl PGF2a, according to receptor subtype studied.	ChEMBL	519	10	2	6	3.8	O=C(O)c1ccc(CCCN2[C@@H](/C=C/C(O)Cc3cccc(OC(F)(F)F)c3)CCS2(=O)=O)s1	nan
	CHEMBL3965497	151320	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10N HCl is added to achieve a pH of 7.4). The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 °C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H−] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations were for 60 min at 25 °C. and were terminated by the addition of 4 ml of ice-cold 50 mM TRIS-HCl, followed by rapid filtration through Whatman GF/B filters and three additional 4 ml washes in a cell harvester (Brandel). Competition studies were performed using a final concentration of 5 nM [3H]-PGE2, or 5 nM [3H] 17-phenyl PGF2a and non-specific binding determined with 10^−5M of unlabeled PGE2, or 17-phenyl PGF2a, according to receptor subtype studied.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10N HCl is added to achieve a pH of 7.4). The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 °C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H−] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations were for 60 min at 25 °C. and were terminated by the addition of 4 ml of ice-cold 50 mM TRIS-HCl, followed by rapid filtration through Whatman GF/B filters and three additional 4 ml washes in a cell harvester (Brandel). Competition studies were performed using a final concentration of 5 nM [3H]-PGE2, or 5 nM [3H] 17-phenyl PGF2a and non-specific binding determined with 10^−5M of unlabeled PGE2, or 17-phenyl PGF2a, according to receptor subtype studied.	ChEMBL	519	10	2	6	3.8	O=C(O)c1ccc(CCCN2[C@@H](/C=C/C(O)Cc3cccc(OC(F)(F)F)c3)CCS2(=O)=O)s1	nan
	56927669	121131	0	None	-	0	Mouse	8.0	pIC50	=	8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	121131	0	None	-	0	Mouse	8.0	pIC50	=	8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	56927669	121131	0	None	-	0	Rat	8.0	pIC50	=	8	Binding	Displacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	121131	0	None	-	0	Rat	8.0	pIC50	=	8	Binding	Displacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	10315	2881	20	None	-	1	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	44230575	2881	20	None	-	1	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	CHEMBL3707245	2881	20	None	-	1	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	122180251	121089	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	432	5	0	6	5.4	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cn1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586314	121089	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	432	5	0	6	5.4	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cn1	10.1021/acs.jmedchem.5b00567
	122180259	121097	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	479	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(S(C)(=O)=O)cc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586322	121097	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	479	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(S(C)(=O)=O)cc1)C2	10.1021/acs.jmedchem.5b00567
	122180261	121099	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(C#N)c1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586324	121099	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(C#N)c1)C2	10.1021/acs.jmedchem.5b00567
	122180282	121117	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	410	4	0	6	4.3	COc1cc(-n2ccc3cc(C#N)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586345	121117	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	410	4	0	6	4.3	COc1cc(-n2ccc3cc(C#N)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	30897313	121084	0	None	-	0	Mouse	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	121084	0	None	-	0	Mouse	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	30897313	121084	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	121084	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180253	121091	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	401	4	0	4	6.0	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586316	121091	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	401	4	0	4	6.0	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccc1)C2	10.1021/acs.jmedchem.5b00567
	122180271	121106	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2ccc(Cl)cc2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586334	121106	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2ccc(Cl)cc2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	44564990	192049	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	538	6	1	5	5.7	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(F)c3)cccc21	10.1016/j.bmcl.2008.12.112
	CHEMBL521777	192049	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	538	6	1	5	5.7	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(F)c3)cccc21	10.1016/j.bmcl.2008.12.112
	122180276	121111	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	399	4	0	5	4.6	COc1cc(-c2cn(C)c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586339	121111	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	399	4	0	5	4.6	COc1cc(-c2cn(C)c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180285	121120	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	372	3	0	4	5.4	c1cncc(CN2CCOc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586348	121120	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	372	3	0	4	5.4	c1cncc(CN2CCOc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
	44409693	165545	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	429	11	2	4	4.3	CCc1ccc(CC(O)CC[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)cc1	10.1016/j.bmcl.2006.01.018
	CHEMBL425950	165545	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	429	11	2	4	4.3	CCc1ccc(CC(O)CC[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)cc1	10.1016/j.bmcl.2006.01.018
	122180269	121104	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2ccccc2Cl)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586332	121104	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2ccccc2Cl)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	44409907	76697	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	10	2	4	3.9	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2ccc(F)cc2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL207237	76697	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	10	2	4	3.9	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2ccc(F)cc2)s1	10.1016/j.bmcl.2006.01.018
	44570000	178074	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	544	7	2	5	6.2	O=C(COc1cccc2[nH]cc(Cc3ccc4ccccc4c3)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/jm9005912
	CHEMBL467632	178074	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	544	7	2	5	6.2	O=C(COc1cccc2[nH]cc(Cc3ccc4ccccc4c3)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/jm9005912
	44409739	139130	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	477	11	2	4	5.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccccc2-c2ccccc2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL379785	139130	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	477	11	2	4	5.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccccc2-c2ccccc2)s1	10.1016/j.bmcl.2006.01.018
	44157014	192017	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	518	6	1	5	5.9	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21	10.1016/j.bmcl.2008.12.112
	CHEMBL521609	192017	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	518	6	1	5	5.9	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21	10.1016/j.bmcl.2008.12.112
	58905349	155737	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	400	6	2	4	4.3	O=C(O)c1ccc(CNC(=O)c2cc(Cl)cnc2Oc2ccc(F)cc2)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4065183	155737	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	400	6	2	4	4.3	O=C(O)c1ccc(CNC(=O)c2cc(Cl)cnc2Oc2ccc(F)cc2)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4552554	212248	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000342a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000342a PTGER2	ChEMBL		None	None	None		O=C(c1ccc(F)cc1)N1CC(COc2ccc(Br)cc2)(C(=O)O)C1	nan
	10047541	131989	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	416	13	4	6	3.8	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccs1	10.1021/jm990542v
	CHEMBL369797	131989	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	416	13	4	6	3.8	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccs1	10.1021/jm990542v
	122180293	121129	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	416	4	0	5	4.9	COc1cc(-c2csc3ccccc23)cc2c1OCC(=O)N(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586357	121129	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	416	4	0	5	4.9	COc1cc(-c2csc3ccccc23)cc2c1OCC(=O)N(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	11955294	144235	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	380	8	3	3	4.2	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3O)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3909111	144235	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	380	8	3	3	4.2	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3O)[C@H](O)C[C@H]1Cl	nan
	11955240	147457	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	352	8	3	3	3.5	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(CO)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3934202	147457	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	352	8	3	3	3.5	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(CO)cc2)[C@H](O)C[C@H]1Cl	nan
	44409910	140378	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	477	11	2	4	5.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2cccc(-c3ccccc3)c2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL382197	140378	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	477	11	2	4	5.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2cccc(-c3ccccc3)c2)s1	10.1016/j.bmcl.2006.01.018
	25195248	182353	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Binding affinity to human EP2 receptor by radioligand binding assayBinding affinity to human EP2 receptor by radioligand binding assay	ChEMBL	540	6	1	4	4.6	CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(F)c(F)cc3F)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2	10.1016/j.bmcl.2008.12.027
	CHEMBL479263	182353	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Binding affinity to human EP2 receptor by radioligand binding assayBinding affinity to human EP2 receptor by radioligand binding assay	ChEMBL	540	6	1	4	4.6	CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(F)c(F)cc3F)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2	10.1016/j.bmcl.2008.12.027
	118756024	121123	3	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	416	5	0	5	5.8	CCOc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586350	121123	3	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	416	5	0	5	5.8	CCOc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180286	121121	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	388	3	1	5	5.1	Oc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586349	121121	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	388	3	1	5	5.1	Oc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	10339756	142553	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.	ChEMBL	380	12	3	4	3.9	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
	CHEMBL3895324	142553	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.	ChEMBL	380	12	3	4	3.9	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
	122180264	121101	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	346	4	0	4	4.2	COc1cc(-c2ccccc2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586327	121101	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	346	4	0	4	4.2	COc1cc(-c2ccccc2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180267	121103	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	360	4	0	4	4.5	COc1cc(-c2cccc(C)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586330	121103	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	360	4	0	4	4.5	COc1cc(-c2cccc(C)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	11955255	145724	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	8	3	3	5.0	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3920560	145724	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	8	3	3	5.0	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	11495634	14736	7	None	-	4	Human	5.8	pIC50	=	5.8	Binding	Inhibition of EP2 receptorInhibition of EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2009.02.112
	CHEMBL1207972	14736	7	None	-	4	Human	5.8	pIC50	=	5.8	Binding	Inhibition of EP2 receptorInhibition of EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2009.02.112
	CHEMBL467114	14736	7	None	-	4	Human	5.8	pIC50	=	5.8	Binding	Inhibition of EP2 receptorInhibition of EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2009.02.112
	9820676	193375	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	369	13	1	3	3.8	CCCCc1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549461	193375	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	369	13	1	3	3.8	CCCCc1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	122180290	121126	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	370	3	0	3	5.9	c1cncc(CN2CCCc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586354	121126	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	370	3	0	3	5.9	c1cncc(CN2CCCc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
	11575201	156880	0	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	C[C@H](NC(=O)c1cc(Cl)ccc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4078648	156880	0	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	C[C@H](NC(=O)c1cc(Cl)ccc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	72695027	105785	0	None	-28	2	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
	CHEMBL3115074	105785	0	None	-28	2	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
	CHEMBL3138992	105785	0	None	-28	2	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
	122180256	121094	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	431	5	0	5	6.0	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cc1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586319	121094	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	431	5	0	5	6.0	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cc1	10.1021/acs.jmedchem.5b00567
	11955406	145571	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	376	10	3	4	3.4	CC(C)(CO)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3919393	145571	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	376	10	3	4	3.4	CC(C)(CO)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	44409738	139076	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	435	10	2	4	4.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(Cl)c2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL379746	139076	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	435	10	2	4	4.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(Cl)c2)s1	10.1016/j.bmcl.2006.01.018
	11577792	158771	15	None	-1819	5	Human	5.7	pIC50	=	5.7	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4099851	158771	15	None	-1819	5	Human	5.7	pIC50	=	5.7	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	46879894	6104	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity to human EP2 receptor by radioligand displacement assayBinding affinity to human EP2 receptor by radioligand displacement assay	ChEMBL	565	6	1	5	7.2	Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(-c3cc(NS(=O)(=O)c4ccc(F)c(F)c4)no3)cc(F)cc12	10.1016/j.bmcl.2009.09.084
	CHEMBL1081186	6104	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity to human EP2 receptor by radioligand displacement assayBinding affinity to human EP2 receptor by radioligand displacement assay	ChEMBL	565	6	1	5	7.2	Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(-c3cc(NS(=O)(=O)c4ccc(F)c(F)c4)no3)cc(F)cc12	10.1016/j.bmcl.2009.09.084
	122180297	121133	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	437	3	1	4	4.9	C[C@@H]1COc2c(Cl)cc(-n3ccc4cc(F)ccc43)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586362	121133	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	437	3	1	4	4.9	C[C@@H]1COc2c(Cl)cc(-n3ccc4cc(F)ccc43)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	1883	3033	71	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
	1916	3033	71	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
	5280360	3033	71	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
	913	3033	71	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
	CHEMBL548	3033	71	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
	DB00917	3033	71	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
	1883	3033	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
	1916	3033	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
	5280360	3033	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
	913	3033	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
	CHEMBL548	3033	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
	DB00917	3033	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
	1883	3033	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
	1916	3033	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
	5280360	3033	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
	913	3033	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
	CHEMBL548	3033	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
	DB00917	3033	71	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
	122180249	121087	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	6	4.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cncnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586312	121087	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	6	4.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cncnc1)C2	10.1021/acs.jmedchem.5b00567
	122180295	121130	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	422	3	1	4	5.3	O=c1cc(CN2CCOc3c(Cl)cc(-c4csc5ccccc45)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586359	121130	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	422	3	1	4	5.3	O=c1cc(CN2CCOc3c(Cl)cc(-c4csc5ccccc45)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	30956824	121086	3	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccncc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586311	121086	3	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccncc1)C2	10.1021/acs.jmedchem.5b00567
	122180250	121088	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	432	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1OC)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586313	121088	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	432	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1OC)C2	10.1021/acs.jmedchem.5b00567
	122180252	121090	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	418	4	1	5	4.7	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(=O)[nH]c1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586315	121090	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	418	4	1	5	4.7	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(=O)[nH]c1)C2	10.1021/acs.jmedchem.5b00567
	122180288	121124	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	386	3	0	4	5.7	Cc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586352	121124	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	386	3	0	4	5.7	Cc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	9885481	193713	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	365	16	2	4	3.0	CCCCCC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	CHEMBL551951	193713	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	365	16	2	4	3.0	CCCCCC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	11955276	150218	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	358	7	3	4	2.9	O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc2c(c1)CCC2O	nan
	CHEMBL3956391	150218	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	358	7	3	4	2.9	O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc2c(c1)CCC2O	nan
	44570666	182688	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to human EP2 receptor by radioligand binding assayBinding affinity to human EP2 receptor by radioligand binding assay	ChEMBL	522	6	1	4	4.5	CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3ccc(F)c(F)c3)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2	10.1016/j.bmcl.2008.12.027
	CHEMBL479664	182688	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to human EP2 receptor by radioligand binding assayBinding affinity to human EP2 receptor by radioligand binding assay	ChEMBL	522	6	1	4	4.5	CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3ccc(F)c(F)c3)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2	10.1016/j.bmcl.2008.12.027
	58905388	158120	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	383	6	2	3	4.4	O=C(O)c1ccc(CNC(=O)c2cc(F)ccc2Oc2ccc(F)cc2)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4092846	158120	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	383	6	2	3	4.4	O=C(O)c1ccc(CNC(=O)c2cc(F)ccc2Oc2ccc(F)cc2)cc1	10.1016/j.bmcl.2017.01.067
	10670992	59741	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	444	13	4	5	4.4	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccc(Cl)c1	10.1021/jm990542v
	CHEMBL173680	59741	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	444	13	4	5	4.4	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccc(Cl)c1	10.1021/jm990542v
	15486806	100021	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	392	13	4	4	3.5	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1	10.1021/jm990542v
	CHEMBL290969	100021	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	392	13	4	4	3.5	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1	10.1021/jm990542v
	45270403	193447	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	351	14	2	4	2.5	CC(C)CC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	CHEMBL550015	193447	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	351	14	2	4	2.5	CC(C)CC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	10180	3535	51	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	402	3	1	3	4.2	Fc1ccc2c(c1)c1CN(CCc1n2CC(=O)O)C(=O)c1cccc2c1cccc2	10.1021/jm400122f
	49843471	3535	51	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	402	3	1	3	4.2	Fc1ccc2c(c1)c1CN(CCc1n2CC(=O)O)C(=O)c1cccc2c1cccc2	10.1021/jm400122f
	CHEMBL2386081	3535	51	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	402	3	1	3	4.2	Fc1ccc2c(c1)c1CN(CCc1n2CC(=O)O)C(=O)c1cccc2c1cccc2	10.1021/jm400122f
	DB12562	3535	51	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	402	3	1	3	4.2	Fc1ccc2c(c1)c1CN(CCc1n2CC(=O)O)C(=O)c1cccc2c1cccc2	10.1021/jm400122f
	45271237	193429	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.0	CCCCc1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549870	193429	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.0	CCCCc1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	122180275	121110	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	4	1	4	4.6	COc1cc(-c2c[nH]c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586338	121110	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	4	1	4	4.6	COc1cc(-c2c[nH]c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	71733910	89904	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	436	3	1	3	4.9	O=C(O)Cn1c2c(c3cc(F)cc(Cl)c31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
	CHEMBL2385900	89904	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	436	3	1	3	4.9	O=C(O)Cn1c2c(c3cc(F)cc(Cl)c31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
	18376258	194228	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	465	9	1	3	5.4	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559065	194228	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	465	9	1	3	5.4	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	122180263	121100	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2cc3ccccc3s2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586326	121100	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2cc3ccccc3s2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	22246983	194189	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	389	11	1	3	4.2	CS(=O)(=O)N(CCCCCCC(=O)O)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL558671	194189	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	389	11	1	3	4.2	CS(=O)(=O)N(CCCCCCC(=O)O)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	1883	3033	71	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	1916	3033	71	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	5280360	3033	71	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	913	3033	71	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	CHEMBL548	3033	71	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	DB00917	3033	71	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	122180284	121119	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	421	4	0	5	4.8	COc1cc(N2CCc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586347	121119	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	421	4	0	5	4.8	COc1cc(N2CCc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180265	121102	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	396	4	0	4	5.3	COc1cc(-c2cccc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586328	121102	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	396	4	0	4	5.3	COc1cc(-c2cccc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180274	121109	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	4	0	5	4.4	COc1cc(-n2ccc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586337	121109	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	4	0	5	4.4	COc1cc(-n2ccc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180254	121092	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	435	4	0	4	6.6	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(Cl)cc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586317	121092	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	435	4	0	4	6.6	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(Cl)cc1)C2	10.1021/acs.jmedchem.5b00567
	122180255	121093	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	415	4	0	4	6.3	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(C)cc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586318	121093	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	415	4	0	4	6.3	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(C)cc1)C2	10.1021/acs.jmedchem.5b00567
	122180260	121098	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	435	4	0	4	6.6	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(Cl)c1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586323	121098	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	435	4	0	4	6.6	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(Cl)c1)C2	10.1021/acs.jmedchem.5b00567
	45269575	194731	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	12	1	4	4.0	CCCCc1ccc(CN(CCCOc2cccc(C(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL562825	194731	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	12	1	4	4.0	CCCCc1ccc(CN(CCCOc2cccc(C(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	45271234	193413	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	405	11	1	4	3.5	CCCCc1ccc(CN(Cc2ccccc2OCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549663	193413	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	405	11	1	4	3.5	CCCCc1ccc(CN(Cc2ccccc2OCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	45268716	194324	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	389	10	1	3	4.0	CCCCc1ccc(CN(c2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559955	194324	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	389	10	1	3	4.0	CCCCc1ccc(CN(c2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	16664733	154289	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of human recombinant EP2 receptor expressed in 293EBNA cellsInhibition of human recombinant EP2 receptor expressed in 293EBNA cells	ChEMBL	483	9	3	5	4.3	CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1	10.1016/j.bmcl.2006.12.025
	CHEMBL400404	154289	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of human recombinant EP2 receptor expressed in 293EBNA cellsInhibition of human recombinant EP2 receptor expressed in 293EBNA cells	ChEMBL	483	9	3	5	4.3	CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1	10.1016/j.bmcl.2006.12.025
	45266955	193972	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	485	10	1	6	3.7	Cn1ccnc1CS(=O)(=O)N(Cc1ccc(C(C)(C)C)cc1)Cc1cccc(OCC(=O)O)c1	10.1016/j.bmcl.2009.01.059
	CHEMBL556416	193972	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	485	10	1	6	3.7	Cn1ccnc1CS(=O)(=O)N(Cc1ccc(C(C)(C)C)cc1)Cc1cccc(OCC(=O)O)c1	10.1016/j.bmcl.2009.01.059
	44627515	195162	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	572	6	1	5	7.2	Cc1cn(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12	10.1021/jm9005912
	CHEMBL565799	195162	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	572	6	1	5	7.2	Cc1cn(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12	10.1021/jm9005912
	11618662	158276	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	421	6	2	5	4.6	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(C#N)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4094572	158276	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	421	6	2	5	4.6	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(C#N)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	11955257	153352	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	410	9	3	3	5.3	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3983069	153352	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	410	9	3	3	5.3	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	1883	3033	71	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
	1916	3033	71	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
	5280360	3033	71	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
	913	3033	71	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
	CHEMBL548	3033	71	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
	DB00917	3033	71	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
	1894	943	35	None	-	5	Human	5.4	pIC50	=	5.4	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	424	11	4	5	3.2	OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O	10.1021/jm990542v
	5311053	943	35	None	-	5	Human	5.4	pIC50	=	5.4	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	424	11	4	5	3.2	OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O	10.1021/jm990542v
	CHEMBL37853	943	35	None	-	5	Human	5.4	pIC50	=	5.4	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	424	11	4	5	3.2	OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O	10.1021/jm990542v
	DB11507	943	35	None	-	5	Human	5.4	pIC50	=	5.4	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	424	11	4	5	3.2	OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O	10.1021/jm990542v
	118175009	136162	0	None	-812	2	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	429	4	2	2	6.7	Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(Cl)c2)cc2ccccc12	10.1016/j.bmcl.2015.11.023
	CHEMBL3740325	136162	0	None	-812	2	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	429	4	2	2	6.7	Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(Cl)c2)cc2ccccc12	10.1016/j.bmcl.2015.11.023
	45271238	193968	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	8	1	3	4.0	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL556333	193968	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	8	1	3	4.0	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	1883	3033	71	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
	1916	3033	71	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
	5280360	3033	71	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
	913	3033	71	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
	CHEMBL548	3033	71	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
	DB00917	3033	71	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
	122180272	121107	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	6	4.8	COc1cc(-c2nsc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586335	121107	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	6	4.8	COc1cc(-c2nsc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180278	121113	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3c(Cl)cccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586341	121113	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3c(Cl)cccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180292	121128	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	3	0	4	5.4	CN1CCN(Cc2cccnc2)Cc2cc(-c3csc4ccccc34)ccc21	10.1021/acs.jmedchem.5b00567
	CHEMBL3586356	121128	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	3	0	4	5.4	CN1CCN(Cc2cccnc2)Cc2cc(-c3csc4ccccc34)ccc21	10.1021/acs.jmedchem.5b00567
	11296282	1382	22	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	590	6	1	5	7.3	Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C	10.1021/jm9005912
	5822	1382	22	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	590	6	1	5	7.3	Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C	10.1021/jm9005912
	CHEMBL565591	1382	22	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	590	6	1	5	7.3	Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C	10.1021/jm9005912
	44230999	166886	20	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	520	11	1	9	3.4	CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4297666	166886	20	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	520	11	1	9	3.4	CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	11955235	152219	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	9	3	3	4.2	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3973312	152219	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	9	3	3	4.2	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	44564571	186233	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	536	6	1	5	6.1	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21	10.1016/j.bmcl.2008.12.112
	CHEMBL489310	186233	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	536	6	1	5	6.1	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21	10.1016/j.bmcl.2008.12.112
	11683088	158432	0	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccc(F)cc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4096216	158432	0	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccc(F)cc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	162671048	182225	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]prostaglandin E2 from full-length recombinant human EP2 receptor expressed in HEK293 cell membranes measured after 120 mins by scintillation counting methodDisplacement of [3H]prostaglandin E2 from full-length recombinant human EP2 receptor expressed in HEK293 cell membranes measured after 120 mins by scintillation counting method	ChEMBL	451	5	1	4	5.4	Cc1c(-c2cccs2)nc2ccc(Br)cc2c1C(=O)NCCc1cccnc1	10.1021/acs.jmedchem.0c00834
	CHEMBL4790821	182225	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]prostaglandin E2 from full-length recombinant human EP2 receptor expressed in HEK293 cell membranes measured after 120 mins by scintillation counting methodDisplacement of [3H]prostaglandin E2 from full-length recombinant human EP2 receptor expressed in HEK293 cell membranes measured after 120 mins by scintillation counting method	ChEMBL	451	5	1	4	5.4	Cc1c(-c2cccs2)nc2ccc(Br)cc2c1C(=O)NCCc1cccnc1	10.1021/acs.jmedchem.0c00834
	9934368	138392	7	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to rat EP2 receptorBinding affinity to rat EP2 receptor	ChEMBL	469	10	2	4	4.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1	10.1021/jm9018756
	CHEMBL378376	138392	7	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to rat EP2 receptorBinding affinity to rat EP2 receptor	ChEMBL	469	10	2	4	4.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1	10.1021/jm9018756
	9934368	138392	7	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	469	10	2	4	4.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL378376	138392	7	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	469	10	2	4	4.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1	10.1016/j.bmcl.2006.01.018
	44627395	195197	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	563	7	1	7	5.6	O=C(COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/jm9005912
	CHEMBL565992	195197	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	563	7	1	7	5.6	O=C(COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/jm9005912
	11955410	151997	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	9	2	4	4.3	COC(=O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C(C)(C)CO)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3971493	151997	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	9	2	4	4.3	COC(=O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C(C)(C)CO)cc2)[C@H](O)C[C@H]1Cl	nan
	5311239	130096	22	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	358	14	4	4	3.5	CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O	10.1021/jm990542v
	CHEMBL36817	130096	22	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	358	14	4	4	3.5	CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O	10.1021/jm990542v
	45268715	194302	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccccc2CCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559760	194302	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccccc2CCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	25114442	3012	49	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	nan
	5817	3012	49	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	nan
	CHEMBL3286797	3012	49	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	nan
	DB12024	3012	49	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	nan
	1883	3033	71	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	1916	3033	71	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	5280360	3033	71	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	913	3033	71	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	CHEMBL548	3033	71	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	DB00917	3033	71	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	1929	1575	46	None	-	2	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	9890801	1575	46	None	-	2	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	CHEMBL563646	1575	46	None	-	2	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	DB12022	1575	46	None	-	2	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	22246895	193891	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	399	14	2	4	3.7	CCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL554823	193891	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	399	14	2	4	3.7	CCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	18376196	193253	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	466	9	1	4	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccn2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL541516	193253	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	466	9	1	4	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccn2)cc1	10.1016/j.bmcl.2009.01.059
	58681352	153805	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	486	10	3	4	5.5	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3Cc3cccc(OCC(=O)O)c3)c2)CCC1	nan
	CHEMBL3986829	153805	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	486	10	3	4	5.5	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3Cc3cccc(OCC(=O)O)c3)c2)CCC1	nan
	122180281	121116	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cccc(Cl)c32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586344	121116	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cccc(Cl)c32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	16048029	193832	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	369	10	1	3	3.8	CC(C)(C)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL553468	193832	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	369	10	1	3	3.8	CC(C)(C)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	122180277	121112	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2cc(Cl)c3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586340	121112	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2cc(Cl)c3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180257	121095	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	459	5	0	6	5.8	COC(=O)c1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cc1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586320	121095	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	459	5	0	6	5.8	COC(=O)c1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cc1	10.1021/acs.jmedchem.5b00567
	122180258	121096	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(C#N)cc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586321	121096	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(C#N)cc1)C2	10.1021/acs.jmedchem.5b00567
	122180291	121127	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	371	3	1	4	5.4	c1cncc(CN2CCNc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586355	121127	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	371	3	1	4	5.4	c1cncc(CN2CCNc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
	11955358	152548	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	364	8	2	2	4.7	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3976116	152548	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	364	8	2	2	4.7	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3)[C@H](O)C[C@H]1Cl	nan
	18376082	193254	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	472	9	1	5	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2nccs2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL541517	193254	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	472	9	1	5	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2nccs2)cc1	10.1016/j.bmcl.2009.01.059
	22246956	194645	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	411	15	1	4	4.2	CCCCCC(=O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL562291	194645	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	411	15	1	4	4.2	CCCCCC(=O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	44409917	138720	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	10	2	4	3.9	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2cccc(F)c2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL378968	138720	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	10	2	4	3.9	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2cccc(F)c2)s1	10.1016/j.bmcl.2006.01.018
	122180273	121108	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	386	4	0	6	3.8	COc1cc(-n2cnc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586336	121108	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	386	4	0	6	3.8	COc1cc(-n2cnc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	11539410	89908	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	438	5	1	3	5.2	CCc1ccc(-c2ccc(C(=O)N3CCc4c(c5ccccc5n4CC(=O)O)C3)cc2)cc1	10.1021/jm400122f
	CHEMBL2385904	89908	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	438	5	1	3	5.2	CCc1ccc(-c2ccc(C(=O)N3CCc4c(c5ccccc5n4CC(=O)O)C3)cc2)cc1	10.1021/jm400122f
	45269576	194309	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccc(CCCC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559820	194309	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccc(CCCC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11653874	89928	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	384	3	1	3	4.1	O=C(O)Cn1c2c(c3ccccc31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
	CHEMBL2386079	89928	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	384	3	1	3	4.1	O=C(O)Cn1c2c(c3ccccc31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
	1955	16	1	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	428	13	4	5	3.6	O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O	10.1021/jm990542v
	5311240	16	1	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	428	13	4	5	3.6	O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O	10.1021/jm990542v
	CHEMBL36041	16	1	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	428	13	4	5	3.6	O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O	10.1021/jm990542v
	44409733	140353	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	401	10	2	4	3.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccccc2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL382029	140353	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	401	10	2	4	3.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccccc2)s1	10.1016/j.bmcl.2006.01.018
	30897313	121084	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	121084	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	42484632	121085	5	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccn1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586310	121085	5	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccn1)C2	10.1021/acs.jmedchem.5b00567
	122180270	121105	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2cccc(Cl)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586333	121105	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2cccc(Cl)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	22246893	194278	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	371	13	1	4	2.7	CCCCc1ccc(CN(CCCCOCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559561	194278	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	371	13	1	4	2.7	CCCCc1ccc(CN(CCCCOCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11524454	933	52	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	Clc1ccc(c(c1)C(=O)N[C@H](c1ccc(cc1)C(=O)O)C)Oc1ccc(cc1)F	10.1016/j.bmcl.2017.01.067
	5857	933	52	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	Clc1ccc(c(c1)C(=O)N[C@H](c1ccc(cc1)C(=O)O)C)Oc1ccc(cc1)F	10.1016/j.bmcl.2017.01.067
	CHEMBL591666	933	52	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	Clc1ccc(c(c1)C(=O)N[C@H](c1ccc(cc1)C(=O)O)C)Oc1ccc(cc1)F	10.1016/j.bmcl.2017.01.067
	68505327	89929	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	418	3	1	3	4.7	O=C(O)Cn1c2c(c3cc(Cl)ccc31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
	CHEMBL2386080	89929	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	418	3	1	3	4.7	O=C(O)Cn1c2c(c3cc(Cl)ccc31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
	44564892	179940	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	554	6	1	5	6.2	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21	10.1016/j.bmcl.2008.12.112
	CHEMBL475348	179940	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	554	6	1	5	6.2	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21	10.1016/j.bmcl.2008.12.112
	10126807	193428	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	405	8	1	4	3.4	CC(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549869	193428	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	405	8	1	4	3.4	CC(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	56927669	121131	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	121131	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	122180296	121132	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	436	3	1	4	5.7	C[C@@H]1COc2c(Cl)cc(-c3csc4ccccc34)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586361	121132	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	436	3	1	4	5.7	C[C@@H]1COc2c(Cl)cc(-c3csc4ccccc34)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	122180279	121114	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586342	121114	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180289	121125	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	406	3	0	4	6.0	Clc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586353	121125	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	406	3	0	4	6.0	Clc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180280	121115	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3ccc(Cl)cc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586343	121115	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3ccc(Cl)cc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	22246765	193528	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	3.7	CCCCc1ccc(CN(CCc2ccc(CC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL550619	193528	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	3.7	CCCCc1ccc(CN(CCc2ccc(CC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	44409918	165420	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	435	10	2	4	4.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccc(Cl)cc2)s1	10.1016/j.bmcl.2006.01.018
	CHEMBL425243	165420	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	435	10	2	4	4.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccc(Cl)cc2)s1	10.1016/j.bmcl.2006.01.018
	11955236	145923	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	396	10	3	3	4.5	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3922121	145923	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	396	10	3	3	4.5	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	122180283	121118	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	5	4.6	COc1cc(-n2ccc3cc(F)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586346	121118	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	5	4.6	COc1cc(-n2ccc3cc(F)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	45268713	194277	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	351	15	2	4	2.6	CCCCCC(O)CCCN(CCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	CHEMBL559560	194277	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	351	15	2	4	2.6	CCCCCC(O)CCCN(CCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	10223499	194667	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	413	15	2	4	4.1	CCCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL562411	194667	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	413	15	2	4	4.1	CCCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	44564893	179941	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	554	6	1	5	6.2	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)cc3Cl)cccc21	10.1016/j.bmcl.2008.12.112
	CHEMBL475349	179941	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	554	6	1	5	6.2	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)cc3Cl)cccc21	10.1016/j.bmcl.2008.12.112
	71733912	89907	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	430	5	1	3	4.5	O=C(O)Cn1c2c(c3cc(F)ccc31)CN(C(=O)CCc1cccc3ccccc13)CC2	10.1021/jm400122f
	CHEMBL2385903	89907	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	430	5	1	3	4.5	O=C(O)Cn1c2c(c3cc(F)ccc31)CN(C(=O)CCc1cccc3ccccc13)CC2	10.1021/jm400122f
	44564804	176126	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	536	6	1	5	6.1	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)cc3Cl)cccc21	10.1016/j.bmcl.2008.12.112
	CHEMBL459885	176126	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	536	6	1	5	6.1	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)cc3Cl)cccc21	10.1016/j.bmcl.2008.12.112
	25114442	3012	49	None	-	1	Human	8.7	pKd	=	8.7	Binding	Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	nan
	5817	3012	49	None	-	1	Human	8.7	pKd	=	8.7	Binding	Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	nan
	CHEMBL3286797	3012	49	None	-	1	Human	8.7	pKd	=	8.7	Binding	Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	nan
	DB12024	3012	49	None	-	1	Human	8.7	pKd	=	8.7	Binding	Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	nan
	9807448	201482	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Compound was evaluated for its competitive binding affinity towards human Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorCompound was evaluated for its competitive binding affinity towards human Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64246	201482	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Compound was evaluated for its competitive binding affinity towards human Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorCompound was evaluated for its competitive binding affinity towards human Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	1883	3033	71	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	1916	3033	71	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	5280360	3033	71	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	913	3033	71	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL548	3033	71	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	DB00917	3033	71	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	51039069	128681	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	419	6	4	4	4.1	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(F)cc2)cc1	nan
	CHEMBL3670659	128681	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	419	6	4	4	4.1	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(F)cc2)cc1	nan
	51039071	128685	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	419	6	4	4	4.1	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccccc3)cc2-c2ccc(F)cc2)o1	nan
	CHEMBL3670663	128685	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	419	6	4	4	4.1	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccccc3)cc2-c2ccc(F)cc2)o1	nan
	10481859	74817	0	None	-4	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C	10.1016/j.bmc.2012.04.008
	CHEMBL2036321	74817	0	None	-4	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C	10.1016/j.bmc.2012.04.008
	1932	2897	4	None	1	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
	5311228	2897	4	None	1	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
	CHEMBL3286796	2897	4	None	1	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
	1883	3033	71	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	1916	3033	71	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	5280360	3033	71	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	913	3033	71	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	CHEMBL548	3033	71	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	DB00917	3033	71	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
	57384034	70963	0	None	-2	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1957436	70963	0	None	-2	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.02.018
	57384034	70963	0	None	-2	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL1957436	70963	0	None	-2	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.04.008
	67078793	128675	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	287	3	2	2	4.2	O=C(O)c1[nH]c(-c2cccs2)cc1-c1ccc(F)cc1	nan
	CHEMBL3670653	128675	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	287	3	2	2	4.2	O=C(O)c1[nH]c(-c2cccs2)cc1-c1ccc(F)cc1	nan
	18376177	3696	45	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	5816	3696	45	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	CHEMBL2107783	3696	45	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	DB12623	3696	45	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
	11855865	152743	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	152743	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	10116114	125365	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL364841	125365	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	13231966	100484	0	None	-141	5	Mouse	7.0	pKi	=	7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.2	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL294108	100484	0	None	-141	5	Mouse	7.0	pKi	=	7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.2	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00365-1
	13231966	100484	0	None	-141	5	Mouse	7.0	pKi	=	7	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	372	13	3	5	3.2	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL294108	100484	0	None	-141	5	Mouse	7.0	pKi	=	7	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	372	13	3	5	3.2	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00364-x
	44455046	95283	0	None	-50118	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	413	8	2	3	3.7	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL258332	95283	0	None	-50118	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	413	8	2	3	3.7	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.11.020
	44304057	201568	0	None	-288	4	Mouse	6.0	pKi	=	6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.6	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL64598	201568	0	None	-288	4	Mouse	6.0	pKi	=	6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.6	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	10181606	204628	0	None	-645	7	Human	5.0	pKi	=	5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	437	5	1	4	5.2	O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(03)00794-7
	CHEMBL87371	204628	0	None	-645	7	Human	5.0	pKi	=	5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	437	5	1	4	5.2	O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(03)00794-7
	118517483	143739	0	None	-93	2	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	CHEMBL3904946	143739	0	None	-93	2	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	71455094	81469	0	None	-407	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	623	12	1	8	6.4	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCCn1cc2ccccc2c1C#N	10.1021/ml300191g
	CHEMBL2164609	81469	0	None	-407	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	623	12	1	8	6.4	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCCn1cc2ccccc2c1C#N	10.1021/ml300191g
	44303627	201515	0	None	467	2	Mouse	8.0	pKi	=	8.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	364	11	3	3	4.5	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64358	201515	0	None	467	2	Mouse	8.0	pKi	=	8.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	364	11	3	3	4.5	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	5311035	97354	27	None	-4	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/j.bmcl.2007.09.074
	CHEMBL271896	97354	27	None	-4	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/j.bmcl.2007.09.074
	52941778	16365	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	712	14	2	4	11.7	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1Oc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1ccccc1Oc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237304	16365	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	712	14	2	4	11.7	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1Oc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1ccccc1Oc1ccccc1	10.1016/j.bmcl.2004.11.051
	5311035	97354	27	None	-4	9	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/j.bmcl.2007.11.020
	CHEMBL271896	97354	27	None	-4	9	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/j.bmcl.2007.11.020
	44390782	64272	0	None	-57	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	402	10	1	3	5.5	COc1cccc(CCCc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL181691	64272	0	None	-57	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	402	10	1	3	5.5	COc1cccc(CCCc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	44303907	201053	0	None	-	1	Mouse	6.0	pKi	=	6.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	390	10	3	4	3.5	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CC#CCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL61925	201053	0	None	-	1	Mouse	6.0	pKi	=	6.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	390	10	3	4	3.5	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CC#CCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	10431288	69024	0	None	-1318	3	Mouse	6.0	pKi	=	6.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	403	12	2	3	4.5	CCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	CHEMBL1929546	69024	0	None	-1318	3	Mouse	6.0	pKi	=	6.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	403	12	2	3	4.5	CCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	46201043	198898	0	None	-5011	3	Mouse	6.0	pKi	=	6.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	453	9	2	3	5.9	C[C@@H](NC(=O)c1cc(COc2ccccc2)ccc1CCC(=O)O)c1cccc2ccccc12	10.1016/j.bmc.2009.11.023
	CHEMBL599154	198898	0	None	-5011	3	Mouse	6.0	pKi	=	6.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	453	9	2	3	5.9	C[C@@H](NC(=O)c1cc(COc2ccccc2)ccc1CCC(=O)O)c1cccc2ccccc12	10.1016/j.bmc.2009.11.023
	9939791	161369	0	None	-912	8	Human	5.0	pKi	=	5.0	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	684	8	1	5	7.2	CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F	10.1016/s0960-894x(99)00465-5
	CHEMBL415310	161369	0	None	-912	8	Human	5.0	pKi	=	5.0	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	684	8	1	5	7.2	CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F	10.1016/s0960-894x(99)00465-5
	9873528	205203	0	None	-72	4	Human	5.0	pKi	=	5.0	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	602	7	1	5	6.9	O=C(NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)OCc1ccccc1	10.1016/s0960-894x(99)00465-5
	CHEMBL91063	205203	0	None	-72	4	Human	5.0	pKi	=	5.0	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	602	7	1	5	6.9	O=C(NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)OCc1ccccc1	10.1016/s0960-894x(99)00465-5
	134155748	150637	0	None	25	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959653	150637	0	None	25	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	11502897	142261	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	142261	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11502897	142261	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	142261	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	119461	317	66	None	-3	10	Human	5.9	pKi	=	5.9	Binding	Inhibition of EP2 receptor (unknown origin) by competitive binding assayInhibition of EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	1896	317	66	None	-3	10	Human	5.9	pKi	=	5.9	Binding	Inhibition of EP2 receptor (unknown origin) by competitive binding assayInhibition of EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	CHEMBL1317823	317	66	None	-3	10	Human	5.9	pKi	=	5.9	Binding	Inhibition of EP2 receptor (unknown origin) by competitive binding assayInhibition of EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	118517359	143863	0	None	-114	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	143863	0	None	-114	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	24952927	199546	0	None	-851	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	461	6	2	3	6.2	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(C(F)(F)F)cc1	10.1021/jm901771h
	CHEMBL603690	199546	0	None	-851	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	461	6	2	3	6.2	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(C(F)(F)F)cc1	10.1021/jm901771h
	44304404	100115	0	None	-23	4	Mouse	7.9	pKi	=	7.9	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	12	3	4	4.1	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	CHEMBL291630	100115	0	None	-23	4	Mouse	7.9	pKi	=	7.9	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	12	3	4	4.1	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	10291963	84284	0	None	-74	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL222715	84284	0	None	-74	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	44520989	198082	0	None	-2	3	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	396	6	2	4	5.0	Cc1c(C)c2c(c(C)c1O)CCC(C)(CCOc1ccccc1/C=C/C(=O)O)O2	10.1016/j.bmc.2009.08.007
	CHEMBL593764	198082	0	None	-2	3	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	396	6	2	4	5.0	Cc1c(C)c2c(c(C)c1O)CCC(C)(CCOc1ccccc1/C=C/C(=O)O)O2	10.1016/j.bmc.2009.08.007
	23016719	199535	0	None	-1	2	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	424	9	1	3	6.1	O=C(O)/C=C/c1ccc(OCc2ccccc2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL603625	199535	0	None	-1	2	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	424	9	1	3	6.1	O=C(O)/C=C/c1ccc(OCc2ccccc2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	44304055	102250	0	None	-371	4	Mouse	5.9	pKi	=	5.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCSCCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL304887	102250	0	None	-371	4	Mouse	5.9	pKi	=	5.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCSCCC(=O)O	10.1016/s0960-894x(01)00364-x
	44304034	198910	0	None	-165	3	Mouse	5.9	pKi	=	5.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1ccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)cc1	10.1016/s0960-894x(01)00364-x
	CHEMBL59921	198910	0	None	-165	3	Mouse	5.9	pKi	=	5.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1ccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)cc1	10.1016/s0960-894x(01)00364-x
	9817405	164851	2	None	-165	6	Human	4.9	pKi	=	4.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	288	4	1	1	4.5	O=C(O)/C=C/c1ccccc1Cc1ccc2ccccc2c1	10.1016/j.bmcl.2006.08.025
	CHEMBL423815	164851	2	None	-165	6	Human	4.9	pKi	=	4.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	288	4	1	1	4.5	O=C(O)/C=C/c1ccccc1Cc1ccc2ccccc2c1	10.1016/j.bmcl.2006.08.025
	72695027	105785	0	None	-28	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
	CHEMBL3115074	105785	0	None	-28	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
	CHEMBL3138992	105785	0	None	-28	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
	72706947	174092	15	None	-5128	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	363	11	2	3	3.4	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL4558749	174092	15	None	-5128	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	363	11	2	3	3.4	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	118517488	153177	0	None	-56	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	CHEMBL3981554	153177	0	None	-56	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	44442327	94023	0	None	-147	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251294	94023	0	None	-147	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	17757350	152222	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	CHEMBL3973347	152222	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	10112412	69125	0	None	-208	3	Mouse	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	413	9	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)c1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933719	69125	0	None	-208	3	Mouse	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	413	9	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)c1	10.1016/j.bmcl.2011.10.109
	10112412	69125	0	None	-208	3	Mouse	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	413	9	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933719	69125	0	None	-208	3	Mouse	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	413	9	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
	118517489	143159	0	None	-44	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	CHEMBL3900245	143159	0	None	-44	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	51039070	128682	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	433	6	5	5	4.2	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(O)cc2)cc1	nan
	CHEMBL3670660	128682	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	433	6	5	5	4.2	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(O)cc2)cc1	nan
	44303626	167619	0	None	-	1	Mouse	7.9	pKi	=	7.9	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL433249	167619	0	None	-	1	Mouse	7.9	pKi	=	7.9	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	57400249	69134	0	None	3	3	Mouse	7.9	pKi	=	7.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	410	9	2	6	3.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)CC2CCCC2)n1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933728	69134	0	None	3	3	Mouse	7.9	pKi	=	7.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	410	9	2	6	3.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)CC2CCCC2)n1	10.1016/j.bmcl.2011.10.109
	10291963	84284	0	None	-74	6	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1021/jm049290a
	CHEMBL222715	84284	0	None	-74	6	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1021/jm049290a
	11315933	122778	4	None	-707	5	Mouse	5.9	pKi	=	5.9	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	413	7	1	4	4.9	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL361457	122778	4	None	-707	5	Mouse	5.9	pKi	=	5.9	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	413	7	1	4	4.9	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
	44394432	126804	0	None	-10	5	Mouse	5.9	pKi	=	5.9	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	457	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@H]2COc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL365908	126804	0	None	-10	5	Mouse	5.9	pKi	=	5.9	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	457	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@H]2COc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	23017109	198391	0	None	-6	2	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	416	10	1	5	4.3	O=C(O)COCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL595830	198391	0	None	-6	2	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	416	10	1	5	4.3	O=C(O)COCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	15907747	205295	0	None	-257	4	Human	4.9	pKi	=	4.9	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	684	8	1	5	7.2	CO[C@@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F	10.1016/s0960-894x(99)00465-5
	CHEMBL91537	205295	0	None	-257	4	Human	4.9	pKi	=	4.9	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	684	8	1	5	7.2	CO[C@@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F	10.1016/s0960-894x(99)00465-5
	118517361	152836	0	None	-218	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	CHEMBL3978590	152836	0	None	-218	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	9975502	94053	0	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251504	94053	0	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	3356	2248	68	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
	4326	2248	68	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
	9867642	2248	68	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
	CHEMBL426559	2248	68	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
	DB11629	2248	68	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
	70667255	150942	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3962183	150942	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	24760052	150653	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3959769	150653	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	44304436	201629	0	None	-35	5	Mouse	7.9	pKi	=	7.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	400	14	3	5	3.8	CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL64854	201629	0	None	-35	5	Mouse	7.9	pKi	=	7.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	400	14	3	5	3.8	CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00364-x
	44320373	204527	0	None	5	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	376	9	1	2	5.8	O=C(O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1	10.1016/s0960-894x(02)00518-8
	CHEMBL86799	204527	0	None	5	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	376	9	1	2	5.8	O=C(O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1	10.1016/s0960-894x(02)00518-8
	52947851	16368	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	528	10	2	2	8.1	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237315	16368	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	528	10	2	2	8.1	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2004.11.051
	52947851	16368	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	528	10	2	2	8.1	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2006.08.025
	CHEMBL1237315	16368	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	528	10	2	2	8.1	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2006.08.025
	9813912	137356	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	264	5	1	1	4.0	O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2006.08.025
	CHEMBL376282	137356	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	264	5	1	1	4.0	O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2006.08.025
	57394140	69029	0	None	-707	3	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	419	13	2	4	4.1	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	CHEMBL1929550	69029	0	None	-707	3	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	419	13	2	4	4.1	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	134146425	148671	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	12	2	2	6.4	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3943966	148671	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	12	2	2	6.4	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	11519006	102013	0	None	-229	6	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]PGE-2 binding to Prostanoid EP2 receptorInhibition of [3H]PGE-2 binding to Prostanoid EP2 receptor	ChEMBL	481	8	1	5	6.1	O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1	10.1016/j.bmcl.2005.04.076
	CHEMBL2373410	102013	0	None	-229	6	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]PGE-2 binding to Prostanoid EP2 receptorInhibition of [3H]PGE-2 binding to Prostanoid EP2 receptor	ChEMBL	481	8	1	5	6.1	O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1	10.1016/j.bmcl.2005.04.076
	CHEMBL3040272	102013	0	None	-229	6	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]PGE-2 binding to Prostanoid EP2 receptorInhibition of [3H]PGE-2 binding to Prostanoid EP2 receptor	ChEMBL	481	8	1	5	6.1	O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1	10.1016/j.bmcl.2005.04.076
	9808508	111072	0	None	-245	3	Human	4.9	pKi	=	4.9	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	586	7	1	4	6.3	O=C(Cc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	CHEMBL328067	111072	0	None	-245	3	Human	4.9	pKi	=	4.9	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	586	7	1	4	6.3	O=C(Cc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	44455115	95118	0	None	-15	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	387	10	2	3	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL257658	95118	0	None	-15	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	387	10	2	3	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	118517359	143863	0	None	-114	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	143863	0	None	-114	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	44289922	162972	0	None	-954	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	339	13	2	3	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL42027	162972	0	None	-954	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	339	13	2	3	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	11855868	152012	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	152012	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	57393340	69132	0	None	-10	4	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	530	12	2	7	4.2	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(COCC(F)(F)F)c2)n1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933726	69132	0	None	-10	4	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	530	12	2	7	4.2	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(COCC(F)(F)F)c2)n1	10.1016/j.bmcl.2011.10.109
	11855868	152012	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	152012	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	57894053	74820	0	None	-79	3	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	551	10	2	8	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036324	74820	0	None	-79	3	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	551	10	2	8	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	155516303	169510	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	7	1	5	5.2	CC(C)(C)c1ccc(CN(Cc2cccc3oc(C(=O)O)cc23)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4443289	169510	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	7	1	5	5.2	CC(C)(C)c1ccc(CN(Cc2cccc3oc(C(=O)O)cc23)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	18973764	16468	0	None	1	4	Human	6.8	pKi	=	6.8	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	346	8	1	2	5.1	O=C(O)c1ccc(CCCc2ccccc2OCc2ccccc2)cc1	10.1016/s0960-894x(03)00794-7
	CHEMBL124199	16468	0	None	1	4	Human	6.8	pKi	=	6.8	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	346	8	1	2	5.1	O=C(O)c1ccc(CCCc2ccccc2OCc2ccccc2)cc1	10.1016/s0960-894x(03)00794-7
	44304058	201487	0	None	-66	5	Mouse	6.8	pKi	=	6.8	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	374	13	3	6	2.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCOCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL64254	201487	0	None	-66	5	Mouse	6.8	pKi	=	6.8	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	374	13	3	6	2.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCOCC(=O)O	10.1016/s0960-894x(01)00364-x
	23017216	197480	0	None	-1380	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	439	9	2	3	5.4	O=C(O)CCc1ccc(COc2ccccc2)cc1C(=O)NCc1cccc2ccccc12	10.1016/j.bmc.2009.11.023
	CHEMBL589411	197480	0	None	-1380	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	439	9	2	3	5.4	O=C(O)CCc1ccc(COc2ccccc2)cc1C(=O)NCc1cccc2ccccc12	10.1016/j.bmc.2009.11.023
	44304051	102287	0	None	-213	4	Mouse	5.8	pKi	=	5.8	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	440	12	3	7	2.4	COc1ccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)cc1	10.1016/s0960-894x(01)00364-x
	CHEMBL305126	102287	0	None	-213	4	Mouse	5.8	pKi	=	5.8	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	440	12	3	7	2.4	COc1ccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)cc1	10.1016/s0960-894x(01)00364-x
	134143292	144695	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	12	1	3	6.5	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3912658	144695	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	12	1	3	6.5	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465595	144890	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)c1	nan
	CHEMBL3914108	144890	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)c1	nan
	59465574	145412	0	None	1	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	400	12	1	4	5.7	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)OC)cc1	nan
	CHEMBL3918084	145412	0	None	1	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	400	12	1	4	5.7	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)OC)cc1	nan
	118517490	152621	0	None	-125	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	CHEMBL3976710	152621	0	None	-125	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	72695027	105785	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1021/ml5000367
	CHEMBL3115074	105785	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1021/ml5000367
	CHEMBL3138992	105785	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1021/ml5000367
	72695027	105785	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	nan
	CHEMBL3115074	105785	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	nan
	CHEMBL3138992	105785	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	nan
	24952577	198877	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	399	6	2	3	5.2	C[C@H](NC(=O)c1cscc1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
	CHEMBL599051	198877	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	399	6	2	3	5.2	C[C@H](NC(=O)c1cscc1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
	1929	1575	46	None	-11	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	9890801	1575	46	None	-11	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	CHEMBL563646	1575	46	None	-11	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	DB12022	1575	46	None	-11	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	44349503	167826	0	None	-100	4	Human	5.8	pKi	=	5.8	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	553	10	1	5	7.1	O=C(CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(03)00794-7
	CHEMBL434637	167826	0	None	-100	4	Human	5.8	pKi	=	5.8	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	553	10	1	5	7.1	O=C(CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(03)00794-7
	44419351	83728	0	None	-28	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	533	12	1	5	6.2	Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL220821	83728	0	None	-28	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	533	12	1	5	6.2	Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
	44324368	96071	0	None	-3	4	Human	4.8	pKi	=	4.8	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	587	6	2	4	6.8	O=C(Nc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	CHEMBL262690	96071	0	None	-3	4	Human	4.8	pKi	=	4.8	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	587	6	2	4	6.8	O=C(Nc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	10144273	204119	0	None	-131	4	Human	4.8	pKi	=	4.8	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	558	8	1	5	7.2	O=C(CCc1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL83450	204119	0	None	-131	4	Human	4.8	pKi	=	4.8	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	558	8	1	5	7.2	O=C(CCc1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	11855871	145875	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	145875	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855871	145875	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	145875	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855866	144069	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	144069	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855866	144069	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	144069	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	53494965	64482	0	None	-5	3	Mouse	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	460	7	2	5	4.5	Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C	10.1016/j.bmc.2011.08.007
	CHEMBL1819611	64482	0	None	-5	3	Mouse	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	460	7	2	5	4.5	Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C	10.1016/j.bmc.2011.08.007
	52947847	16361	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccc(/C=C/C(=O)O)cc2)c1OCc1ccccc1.Cc1cccc(C/C=C\c2ccc(/C=C/C(=O)O)cc2)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237300	16361	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccc(/C=C/C(=O)O)cc2)c1OCc1ccccc1.Cc1cccc(C/C=C\c2ccc(/C=C/C(=O)O)cc2)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	11314979	65778	0	None	-11	4	Mouse	5.8	pKi	=	5.8	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	379	7	1	4	4.8	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(C)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL183933	65778	0	None	-11	4	Mouse	5.8	pKi	=	5.8	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	379	7	1	4	4.8	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(C)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	11234840	124535	0	None	-4	2	Mouse	5.8	pKi	=	5.8	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	395	8	1	5	4.5	CCCCOc1cccc(C(=O)n2c(C)c(CC(=O)O)c3cc(OC)ccc32)c1	10.1016/j.bmcl.2004.06.006
	CHEMBL364421	124535	0	None	-4	2	Mouse	5.8	pKi	=	5.8	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	395	8	1	5	4.5	CCCCOc1cccc(C(=O)n2c(C)c(CC(=O)O)c3cc(OC)ccc32)c1	10.1016/j.bmcl.2004.06.006
	56949973	69030	0	None	-3388	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	407	11	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	CHEMBL1929551	69030	0	None	-3388	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	407	11	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	57894092	74808	0	None	-8511	3	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	12	2	6	4.5	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2nc3ccccc3o2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036312	74808	0	None	-8511	3	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	12	2	6	4.5	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2nc3ccccc3o2)c1	10.1016/j.bmc.2012.04.008
	10157810	63456	0	None	3	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	400	9	1	3	5.6	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1021/ml300191g
	CHEMBL180191	63456	0	None	3	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	400	9	1	3	5.6	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1021/ml300191g
	44442334	94092	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	327	7	1	2	3.8	CC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251710	94092	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	327	7	1	2	3.8	CC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	11495634	14736	7	None	-218	4	Mouse	5.8	pKi	=	5.8	Binding	Antagonist activity at mouse EP2 receptorAntagonist activity at mouse EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2012.11.046
	CHEMBL1207972	14736	7	None	-218	4	Mouse	5.8	pKi	=	5.8	Binding	Antagonist activity at mouse EP2 receptorAntagonist activity at mouse EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2012.11.046
	CHEMBL467114	14736	7	None	-218	4	Mouse	5.8	pKi	=	5.8	Binding	Antagonist activity at mouse EP2 receptorAntagonist activity at mouse EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2012.11.046
	92135977	152363	0	None	-275	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	CHEMBL3974652	152363	0	None	-275	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	52945421	16359	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	740	16	2	4	11.2	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(OCc2ccccc2)c1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(OCc2ccccc2)c1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237298	16359	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	740	16	2	4	11.2	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(OCc2ccccc2)c1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(OCc2ccccc2)c1	10.1016/j.bmcl.2004.11.051
	21362912	170609	0	None	-8	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	535	12	1	5	6.7	O=C(CCCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL445895	170609	0	None	-8	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	535	12	1	5	6.7	O=C(CCCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	23017362	198295	0	None	-45	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	414	10	1	4	5.1	O=C(O)CCCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL595157	198295	0	None	-45	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	414	10	1	4	5.1	O=C(O)CCCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	11577792	158771	15	None	-1819	5	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	CHEMBL4099851	158771	15	None	-1819	5	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
	10448293	153887	0	None	-41	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	313	6	1	2	3.4	CC(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL398947	153887	0	None	-41	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	313	6	1	2	3.4	CC(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	11855324	142073	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142073	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	57395059	69131	0	None	-12	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933725	69131	0	None	-12	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1016/j.bmcl.2011.10.109
	57395059	69131	0	None	-12	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1933725	69131	0	None	-12	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1016/j.bmc.2012.02.018
	11855865	152743	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	152743	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	57403612	70961	0	None	-239	3	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	433	9	2	4	4.2	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)s1	10.1016/j.bmc.2012.02.018
	CHEMBL1957434	70961	0	None	-239	3	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	433	9	2	4	4.2	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)s1	10.1016/j.bmc.2012.02.018
	15948325	2490	39	None	-1548	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	603	11	1	8	4.7	CCOc1c2CN(C(=O)c2c(c2c1nccc2)OCC)c1ccc(cc1C)CS(=O)(=O)NC(=O)Cc1ccccc1OC	10.1016/j.bmcl.2008.01.103
	5856	2490	39	None	-1548	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	603	11	1	8	4.7	CCOc1c2CN(C(=O)c2c(c2c1nccc2)OCC)c1ccc(cc1C)CS(=O)(=O)NC(=O)Cc1ccccc1OC	10.1016/j.bmcl.2008.01.103
	CHEMBL402162	2490	39	None	-1548	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	603	11	1	8	4.7	CCOc1c2CN(C(=O)c2c(c2c1nccc2)OCC)c1ccc(cc1C)CS(=O)(=O)NC(=O)Cc1ccccc1OC	10.1016/j.bmcl.2008.01.103
	59465577	142657	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	13	2	2	6.8	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3896183	142657	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	13	2	2	6.8	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	57893982	74814	0	None	-4	3	Mouse	8.7	pKi	=	8.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	508	10	2	6	5.1	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	CHEMBL2036318	74814	0	None	-4	3	Mouse	8.7	pKi	=	8.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	508	10	2	6	5.1	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	57464006	74818	0	None	-17	4	Mouse	8.7	pKi	=	8.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	534	10	2	7	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036322	74818	0	None	-17	4	Mouse	8.7	pKi	=	8.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	534	10	2	7	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	9807448	201482	0	None	-1	4	Mouse	8.7	pKi	=	8.7	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64246	201482	0	None	-1	4	Mouse	8.7	pKi	=	8.7	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	67078538	128676	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	269	3	3	3	3.3	O=C(O)c1[nH]c(-c2ccoc2)cc1-c1ccc(O)cc1	nan
	CHEMBL3670654	128676	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	269	3	3	3	3.3	O=C(O)c1[nH]c(-c2ccoc2)cc1-c1ccc(O)cc1	nan
	44303952	100419	0	None	41	4	Mouse	7.7	pKi	=	7.7	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	420	14	3	4	4.8	CCCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL293697	100419	0	None	41	4	Mouse	7.7	pKi	=	7.7	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	420	14	3	4	4.8	CCCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	10361472	64877	0	None	-199	3	Mouse	5.7	pKi	=	5.7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)cc3c(CC(=O)O)cccc32)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL182555	64877	0	None	-199	3	Mouse	5.7	pKi	=	5.7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)cc3c(CC(=O)O)cccc32)cc1	10.1016/j.bmcl.2004.07.039
	10118889	204550	0	None	-74	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1cccc(CSCCc2ccccc2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL86933	204550	0	None	-74	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1cccc(CSCCc2ccccc2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	11187675	64883	0	None	-61	4	Mouse	5.7	pKi	=	5.7	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL182572	64883	0	None	-61	4	Mouse	5.7	pKi	=	5.7	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)cc1	10.1016/j.bmcl.2004.06.006
	12002527	74810	0	None	-19952	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	493	12	2	5	5.1	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2cc3ccccc3o2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036314	74810	0	None	-19952	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	493	12	2	5	5.1	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2cc3ccccc3o2)c1	10.1016/j.bmc.2012.04.008
	24953628	198919	0	None	-63	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	427	6	2	3	5.8	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(Cl)cc1	10.1021/jm901771h
	CHEMBL599262	198919	0	None	-63	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	427	6	2	3	5.8	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(Cl)cc1	10.1021/jm901771h
	57529188	146662	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	146662	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	57529188	146662	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	146662	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	44444721	153872	0	None	-77	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	508	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2cccc(I)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL398827	153872	0	None	-77	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	508	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2cccc(I)c2)cc1	10.1016/j.bmcl.2007.09.074
	44455084	97418	0	None	-10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	399	10	2	3	4.2	CCCCC1([C@@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.11.020
	CHEMBL272277	97418	0	None	-10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	399	10	2	3	4.2	CCCCC1([C@@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.11.020
	58932681	74822	0	None	-100	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1ccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036326	74822	0	None	-100	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1ccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1	10.1016/j.bmc.2012.04.008
	10116116	64080	0	None	-26	5	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	CHEMBL1813115	64080	0	None	-26	5	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	10206535	66239	0	None	-398	4	Mouse	5.7	pKi	=	5.7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	488	6	1	6	4.7	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccc(F)cc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL185251	66239	0	None	-398	4	Mouse	5.7	pKi	=	5.7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	488	6	1	6	4.7	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccc(F)cc3O2)cc1	10.1016/j.bmcl.2004.07.039
	44320126	204686	0	None	-17	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	537	11	1	7	6.2	Cc1cccc(OCCCOc2ccc(-c3ccccc3COC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	CHEMBL87816	204686	0	None	-17	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	537	11	1	7	6.2	Cc1cccc(OCCCOc2ccc(-c3ccccc3COC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	22009011	63742	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	468	8	2	3	6.7	Cc1cccc(/C=C/C(O)c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	CHEMBL180742	63742	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	468	8	2	3	6.7	Cc1cccc(/C=C/C(O)c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	11187675	64883	0	None	-61	4	Mouse	5.7	pKi	=	5.7	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL182572	64883	0	None	-61	4	Mouse	5.7	pKi	=	5.7	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)cc1	10.1016/j.bmcl.2004.06.006
	44419380	82666	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	529	10	1	5	6.4	Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL218178	82666	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	529	10	1	5	6.4	Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
	44419384	82667	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	529	10	1	5	6.4	Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL218179	82667	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	529	10	1	5	6.4	Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
	57894081	74804	0	None	-3467	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	503	12	2	4	5.6	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccc3ccccc3c2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036308	74804	0	None	-3467	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	503	12	2	4	5.6	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccc3ccccc3c2)c1	10.1016/j.bmc.2012.04.008
	23017746	198167	0	None	-13	3	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	414	8	1	3	6.2	O=C(O)/C=C/c1ccc(Cc2cccs2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL594365	198167	0	None	-13	3	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	414	8	1	3	6.2	O=C(O)/C=C/c1ccc(Cc2cccs2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	9846782	100438	4	None	-676	3	Mouse	5.7	pKi	=	5.7	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	454	13	3	7	2.6	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	CHEMBL293856	100438	4	None	-676	3	Mouse	5.7	pKi	=	5.7	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	454	13	3	7	2.6	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	15907748	110976	0	None	-147	4	Human	4.7	pKi	=	4.7	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	615	7	2	4	7.0	C[C@H](NC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1	10.1016/s0960-894x(99)00465-5
	CHEMBL327597	110976	0	None	-147	4	Human	4.7	pKi	=	4.7	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	615	7	2	4	7.0	C[C@H](NC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1	10.1016/s0960-894x(99)00465-5
	138	3032	84	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	1882	3032	84	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	5280723	3032	84	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL495	3032	84	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	DB00770	3032	84	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	1883	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
	1916	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
	5280360	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
	913	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
	CHEMBL548	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
	DB00917	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
	1883	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	1916	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	5280360	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	913	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	CHEMBL548	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	DB00917	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	57396660	70964	0	None	-1819	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	544	10	2	6	5.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc4ccccc4c3)c2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1957437	70964	0	None	-1819	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	544	10	2	6	5.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc4ccccc4c3)c2)n1	10.1016/j.bmc.2012.02.018
	57396660	70964	0	None	-1819	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	544	10	2	6	5.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc4ccccc4c3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL1957437	70964	0	None	-1819	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	544	10	2	6	5.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc4ccccc4c3)c2)n1	10.1016/j.bmc.2012.04.008
	10348321	74821	0	None	-87	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	585	10	2	8	6.0	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036325	74821	0	None	-87	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	585	10	2	8	6.0	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	58932678	74938	0	None	-104	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12	10.1016/j.bmc.2012.04.008
	CHEMBL2037290	74938	0	None	-104	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12	10.1016/j.bmc.2012.04.008
	56672020	64494	0	None	-1	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	7	2	5	4.6	CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3F)c(Cl)c2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	CHEMBL1819623	64494	0	None	-1	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	7	2	5	4.6	CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3F)c(Cl)c2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	11337782	84519	0	None	-12	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	373	10	2	3	3.6	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2CC[C@@H](O)CCC2CCC2)cc1	10.1021/jm049290a
	CHEMBL223744	84519	0	None	-12	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	373	10	2	3	3.6	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2CC[C@@H](O)CCC2CCC2)cc1	10.1021/jm049290a
	9863804	93664	0	None	-8	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	362	11	2	4	2.7	CCCCCC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249136	93664	0	None	-8	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	362	11	2	4	2.7	CCCCCC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	9938669	167495	0	None	-154	4	Human	4.7	pKi	=	4.7	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	602	8	1	5	6.2	O=C(COc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	CHEMBL432380	167495	0	None	-154	4	Human	4.7	pKi	=	4.7	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	602	8	1	5	6.2	O=C(COc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	10113454	176927	0	None	-1380	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	429	12	2	3	4.4	O=C(O)CCCCCCN1C(=O)CC[C@@H]1CC[C@@H](O)Cc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL46395	176927	0	None	-1380	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	429	12	2	3	4.4	O=C(O)CCCCCCN1C(=O)CC[C@@H]1CC[C@@H](O)Cc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
	118517483	143739	0	None	-93	2	Human	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	CHEMBL3904946	143739	0	None	-93	2	Human	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	11488860	19095	0	None	-5370	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to prostanoid receptor EP2 receptorBinding affinity to prostanoid receptor EP2 receptor	ChEMBL	497	5	1	4	5.7	C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O	10.1016/j.bmcl.2010.10.018
	CHEMBL1290413	19095	0	None	-5370	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to prostanoid receptor EP2 receptorBinding affinity to prostanoid receptor EP2 receptor	ChEMBL	497	5	1	4	5.7	C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O	10.1016/j.bmcl.2010.10.018
	24760055	143356	0	None	-2	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	CHEMBL3901873	143356	0	None	-2	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	24760055	143356	0	None	-2	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	CHEMBL3901873	143356	0	None	-2	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	11855591	143903	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	143903	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	11855591	143903	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	143903	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	10414412	74816	0	None	-6	3	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)c(C)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036320	74816	0	None	-6	3	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)c(C)c1	10.1016/j.bmc.2012.04.008
	11408533	140796	0	None	-89	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	459	6	1	5	4.5	CC(=O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1016/j.bmcl.2006.02.062
	CHEMBL383484	140796	0	None	-89	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	459	6	1	5	4.5	CC(=O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1016/j.bmcl.2006.02.062
	11408533	140796	0	None	-89	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	459	6	1	5	4.5	CC(=O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
	CHEMBL383484	140796	0	None	-89	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	459	6	1	5	4.5	CC(=O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
	11743212	16982	0	None	-758	7	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	426	7	1	3	6.8	O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL125588	16982	0	None	-758	7	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	426	7	1	3	6.8	O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	56658143	64474	0	None	-16	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	468	8	2	6	3.4	CN1C[C@@H](COc2ccc(S(=O)(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	CHEMBL1819604	64474	0	None	-16	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	468	8	2	6	3.4	CN1C[C@@H](COc2ccc(S(=O)(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	9809136	106406	0	None	-2290	8	Human	4.6	pKi	=	4.6	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	614	7	1	4	7.1	CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1	10.1016/s0960-894x(99)00465-5
	CHEMBL314533	106406	0	None	-2290	8	Human	4.6	pKi	=	4.6	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	614	7	1	4	7.1	CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1	10.1016/s0960-894x(99)00465-5
	9874010	205461	0	None	-1348	8	Human	4.6	pKi	=	4.6	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	629	8	1	4	6.9	CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	CHEMBL92539	205461	0	None	-1348	8	Human	4.6	pKi	=	4.6	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	629	8	1	4	6.9	CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
	10229201	155036	0	None	-87	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	508	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(I)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL404414	155036	0	None	-87	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	508	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(I)c2)cc1	10.1016/j.bmcl.2007.09.074
	10076580	74939	0	None	-158	3	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	563	10	2	8	5.5	Cc1cc(C)c2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1	10.1016/j.bmc.2012.04.008
	CHEMBL2037291	74939	0	None	-158	3	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	563	10	2	8	5.5	Cc1cc(C)c2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1	10.1016/j.bmc.2012.04.008
	132836	59383	20	None	1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	10.1021/jm401431x
	CHEMBL1722929	59383	20	None	1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	10.1021/jm401431x
	57403799	69126	0	None	-6	2	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	398	9	2	5	2.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)co2)c1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933720	69126	0	None	-6	2	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	398	9	2	5	2.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)co2)c1	10.1016/j.bmcl.2011.10.109
	57403799	69126	0	None	-6	2	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	398	9	2	5	2.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)co2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933720	69126	0	None	-6	2	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	398	9	2	5	2.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)co2)c1	10.1016/j.bmc.2012.02.018
	5311035	97354	27	None	-4	9	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1021/jm401431x
	CHEMBL271896	97354	27	None	-4	9	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1021/jm401431x
	44303980	167511	0	None	-	1	Mouse	5.6	pKi	=	5.6	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	408	13	2	5	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL432522	167511	0	None	-	1	Mouse	5.6	pKi	=	5.6	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	408	13	2	5	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/s0960-894x(01)00359-6
	22009004	141219	0	None	-2884	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	545	11	1	6	6.1	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1021/ml300191g
	CHEMBL385955	141219	0	None	-2884	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	545	11	1	6	6.1	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1021/ml300191g
	10270893	93793	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	376	12	2	4	3.1	CCCCCC(O)CCCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249954	93793	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	376	12	2	4	3.1	CCCCCC(O)CCCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	44303889	201526	0	None	-	1	Mouse	7.6	pKi	=	7.6	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	414	10	3	4	4.2	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64423	201526	0	None	-	1	Mouse	7.6	pKi	=	7.6	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	414	10	3	4	4.2	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/s0960-894x(01)00359-6
	17751059	147736	0	None	56	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3936540	147736	0	None	56	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	21974328	65938	0	None	-26	5	Mouse	6.6	pKi	=	6.6	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	443	6	1	6	4.4	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Oc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL184684	65938	0	None	-26	5	Mouse	6.6	pKi	=	6.6	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	443	6	1	6	4.4	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Oc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	10228100	64083	0	None	-43	5	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	488	6	1	6	4.7	Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	CHEMBL1813118	64083	0	None	-43	5	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	488	6	1	6	4.7	Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	44349551	16635	0	None	-47	4	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	415	8	2	4	6.2	O=C(O)CNc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL124675	16635	0	None	-47	4	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	415	8	2	4	6.2	O=C(O)CNc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	10158725	16649	0	None	-109	4	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL124738	16649	0	None	-109	4	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	44320405	105685	0	None	-5	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.2	O=C(NS(=O)(=O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL313700	105685	0	None	-5	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.2	O=C(NS(=O)(=O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)c1cccs1	10.1016/s0960-894x(02)00518-8
	52944194	16366	0	None	-194	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	936	18	4	6	12.8	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(CO)c1OCc1c(Cl)cccc1Cl.O=C(O)/C=C/c1ccccc1C/C=C/c1cccc(CO)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	CHEMBL1237305	16366	0	None	-194	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	936	18	4	6	12.8	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(CO)c1OCc1c(Cl)cccc1Cl.O=C(O)/C=C/c1ccccc1C/C=C/c1cccc(CO)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	52947852	16369	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	588	12	2	4	8.1	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1.COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237316	16369	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	588	12	2	4	8.1	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1.COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2004.11.051
	52947852	16369	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	588	12	2	4	8.1	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1.COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2006.08.025
	CHEMBL1237316	16369	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	588	12	2	4	8.1	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1.COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2006.08.025
	44419388	83002	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	294	6	1	2	4.0	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2006.08.025
	CHEMBL219590	83002	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	294	6	1	2	4.0	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2006.08.025
	11339240	84304	0	None	-3548	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	423	10	2	4	3.2	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1021/jm049290a
	CHEMBL222834	84304	0	None	-3548	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	423	10	2	4	3.2	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1021/jm049290a
	9885106	84349	0	None	-1258	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1016/j.bmcl.2011.10.109
	CHEMBL223151	84349	0	None	-1258	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1016/j.bmcl.2011.10.109
	9885106	84349	0	None	-1258	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1016/j.bmc.2012.02.018
	CHEMBL223151	84349	0	None	-1258	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1016/j.bmc.2012.02.018
	44304258	101886	0	None	-114	3	Mouse	5.6	pKi	=	5.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1ccccc1C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL303787	101886	0	None	-114	3	Mouse	5.6	pKi	=	5.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1ccccc1C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	44455158	97272	0	None	-933	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	331	8	2	3	2.6	CCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL271488	97272	0	None	-933	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	331	8	2	3	2.6	CCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	9821171	97417	0	None	-51286	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	379	8	2	3	3.1	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL272276	97417	0	None	-51286	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	379	8	2	3	3.1	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.11.020
	44304011	201120	0	None	-83	3	Mouse	5.6	pKi	=	5.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	440	12	3	7	2.4	COc1ccccc1C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL62305	201120	0	None	-83	3	Mouse	5.6	pKi	=	5.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	440	12	3	7	2.4	COc1ccccc1C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	44290263	100859	0	None	-3235	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	453	12	3	4	5.2	Cc1cc(O)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCCCCCC(=O)O)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL296715	100859	0	None	-3235	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	453	12	3	4	5.2	Cc1cc(O)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCCCCCC(=O)O)c1	10.1016/j.bmcl.2004.01.063
	77050677	128062	0	None	-588	2	Human	6.6	pKi	=	6.6	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3]H-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3]H-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	385	10	2	4	3.7	CC(C)[C@@H](OCCOc1ccccc1)C(=O)N[C@@H](C)c1ccc(C(=O)O)cc1	nan
	CHEMBL3667607	128062	0	None	-588	2	Human	6.6	pKi	=	6.6	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3]H-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3]H-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	385	10	2	4	3.7	CC(C)[C@@H](OCCOc1ccccc1)C(=O)N[C@@H](C)c1ccc(C(=O)O)cc1	nan
	11855325	144158	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144158	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	21362900	204125	0	None	-58	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL83518	204125	0	None	-58	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	11418818	66329	0	None	-14	4	Mouse	5.6	pKi	=	5.6	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	423	10	1	5	5.2	CCCCOc1ccc(C(=O)n2c(C)c(CCCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL185369	66329	0	None	-14	4	Mouse	5.6	pKi	=	5.6	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	423	10	1	5	5.2	CCCCOc1ccc(C(=O)n2c(C)c(CCCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	53358921	64110	0	None	-562	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	482	7	1	5	5.4	CCN1c2ccccc2C[C@@H]1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1	10.1016/j.bmc.2011.06.014
	CHEMBL1813287	64110	0	None	-562	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	482	7	1	5	5.4	CCN1c2ccccc2C[C@@H]1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1	10.1016/j.bmc.2011.06.014
	10181606	204628	0	None	-645	7	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	437	5	1	4	5.2	O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL87371	204628	0	None	-645	7	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	437	5	1	4	5.2	O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	118517360	143443	0	None	-1380	2	Human	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	412	8	2	3	4.7	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Cl)c2)cc1	nan
	CHEMBL3902700	143443	0	None	-1380	2	Human	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	412	8	2	3	4.7	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Cl)c2)cc1	nan
	44444714	93704	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	362	10	2	4	2.6	CCCC(C)C(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249341	93704	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	362	10	2	4	2.6	CCCC(C)C(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	57893848	74819	0	None	-234	2	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	535	10	2	8	4.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036323	74819	0	None	-234	2	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	535	10	2	8	4.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	21974362	121530	0	None	-1	4	Mouse	6.6	pKi	=	6.6	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	455	6	1	5	4.9	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2COc3ccccc3C2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL359564	121530	0	None	-1	4	Mouse	6.6	pKi	=	6.6	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	455	6	1	5	4.9	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2COc3ccccc3C2)cc1	10.1016/j.bmcl.2004.07.039
	9886718	201473	0	None	-398	4	Mouse	6.6	pKi	=	6.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL64217	201473	0	None	-398	4	Mouse	6.6	pKi	=	6.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
	118175009	136162	0	None	-812	2	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	429	4	2	2	6.7	Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(Cl)c2)cc2ccccc12	10.1016/j.bmcl.2015.11.023
	CHEMBL3740325	136162	0	None	-812	2	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	429	4	2	2	6.7	Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(Cl)c2)cc2ccccc12	10.1016/j.bmcl.2015.11.023
	10157813	199931	0	None	-177	4	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	400	9	1	4	4.7	O=C(O)CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL605833	199931	0	None	-177	4	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	400	9	1	4	4.7	O=C(O)CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	59465587	144657	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	372	13	2	2	6.5	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)O)cc1	nan
	CHEMBL3912391	144657	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	372	13	2	2	6.5	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)O)cc1	nan
	10205205	93734	0	None	-47	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	466	10	2	5	3.3	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(OC(F)(F)F)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249539	93734	0	None	-47	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	466	10	2	5	3.3	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(OC(F)(F)F)c2)cc1	10.1016/j.bmcl.2007.09.074
	10089562	153888	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL398948	153888	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	44304335	201289	0	None	-37	4	Mouse	6.5	pKi	=	6.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	422	10	4	4	4.0	Cc1cc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)ccc1O	10.1016/s0960-894x(01)00365-1
	CHEMBL63061	201289	0	None	-37	4	Mouse	6.5	pKi	=	6.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	422	10	4	4	4.0	Cc1cc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)ccc1O	10.1016/s0960-894x(01)00365-1
	21362879	16391	0	None	-107	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1cc(-c2ccccc2OCc2ccccc2)cs1	10.1016/s0960-894x(03)00794-7
	CHEMBL123855	16391	0	None	-107	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1cc(-c2ccccc2OCc2ccccc2)cs1	10.1016/s0960-894x(03)00794-7
	21362853	18346	0	None	-32	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	408	8	1	2	6.6	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2COc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL127482	18346	0	None	-32	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	408	8	1	2	6.6	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2COc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	12112239	106078	0	None	-8	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	549	12	1	6	6.3	Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	CHEMBL314200	106078	0	None	-8	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	549	12	1	6	6.3	Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	21362893	204604	0	None	-54	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	535	12	1	6	6.0	Cc1cccc(OCCCOc2ccc(-c3ccccc3CCC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	CHEMBL87263	204604	0	None	-54	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	535	12	1	6	6.0	Cc1cccc(OCCCOc2ccc(-c3ccccc3CCC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	44320321	204708	0	None	-6	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	563	12	1	6	6.6	Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	CHEMBL87975	204708	0	None	-6	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	563	12	1	6	6.6	Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	52941777	16363	0	None	1	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	744	16	2	4	10.9	Cc1cccc(/C=C/Cc2ccccc2CC(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2CC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237302	16363	0	None	1	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	744	16	2	4	10.9	Cc1cccc(/C=C/Cc2ccccc2CC(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2CC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	44393681	66527	0	None	-1	3	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	409	9	1	5	5.2	CCCCOc1ccc(C(=O)n2c(CCC)c(C(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL186244	66527	0	None	-1	3	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	409	9	1	5	5.2	CCCCOc1ccc(C(=O)n2c(CCC)c(C(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	10202765	172118	0	None	-18197	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	427	11	2	3	4.2	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL45008	172118	0	None	-18197	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	427	11	2	3	4.2	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
	71458758	120349	0	None	-21	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	615	14	1	4	7.8	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C	10.1021/ml300191g
	CHEMBL2164612	120349	0	None	-21	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	615	14	1	4	7.8	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C	10.1021/ml300191g
	CHEMBL3558858	120349	0	None	-21	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	615	14	1	4	7.8	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C	10.1021/ml300191g
	57396825	69130	0	None	-6	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	398	11	2	6	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933724	69130	0	None	-6	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	398	11	2	6	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2011.10.109
	57396825	69130	0	None	-6	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	398	11	2	6	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2012.02.018
	CHEMBL1933724	69130	0	None	-6	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	398	11	2	6	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2012.02.018
	57394893	70962	0	None	-3	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1957435	70962	0	None	-3	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.02.018
	57394893	70962	0	None	-3	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL1957435	70962	0	None	-3	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.04.008
	51039072	128684	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	4	5	4.3	COc1ccc(-c2cc(-c3ccccc3)[nH]c2C(=O)Nc2ccc(C(=O)NO)o2)cc1	nan
	CHEMBL3670662	128684	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	4	5	4.3	COc1ccc(-c2cc(-c3ccccc3)[nH]c2C(=O)Nc2ccc(C(=O)NO)o2)cc1	nan
	9807448	201482	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1021/jm401431x
	CHEMBL64246	201482	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1021/jm401431x
	67078580	128678	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	435	6	2	5	4.7	COC(=O)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(F)cc2)nc1	nan
	CHEMBL3670656	128678	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	435	6	2	5	4.7	COC(=O)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(F)cc2)nc1	nan
	51039068	128680	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	436	6	4	5	4.0	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(F)cc2)nc1	nan
	CHEMBL3670658	128680	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	436	6	4	5	4.0	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(F)cc2)nc1	nan
	44304164	201543	0	None	-	1	Mouse	7.5	pKi	=	7.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	378	11	3	4	3.6	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64483	201543	0	None	-	1	Mouse	7.5	pKi	=	7.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	378	11	3	4	3.6	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	15947857	154975	8	None	-269	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	767	12	1	9	6.3	COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1	10.1016/j.bmcl.2008.01.103
	CHEMBL404199	154975	8	None	-269	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	767	12	1	9	6.3	COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1	10.1016/j.bmcl.2008.01.103
	44320294	105527	0	None	-4	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	557	12	1	6	5.7	O=S(=O)(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL313266	105527	0	None	-4	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	557	12	1	6	5.7	O=S(=O)(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	230826	92998	27	None	-19	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity at prostanoid EP2 receptorBinding affinity at prostanoid EP2 receptor	ChEMBL	268	4	1	2	3.9	O=C(O)COc1ccc(Cl)cc1C1CCCCC1	10.1016/j.bmcl.2007.05.019
	CHEMBL245908	92998	27	None	-19	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity at prostanoid EP2 receptorBinding affinity at prostanoid EP2 receptor	ChEMBL	268	4	1	2	3.9	O=C(O)COc1ccc(Cl)cc1C1CCCCC1	10.1016/j.bmcl.2007.05.019
	44269516	43386	24	None	-87	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CCC1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	CHEMBL15096	43386	24	None	-87	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CCC1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	10413147	8992	0	None	-13182	3	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	486	10	3	3	7.2	Cc1cc(C)cc(Nc2ccc(CCC(=O)O)c(C(=O)N[C@H](CC(C)C)c3cc(C)cc(C)c3)c2)c1	10.1016/j.bmc.2010.03.028
	CHEMBL1099047	8992	0	None	-13182	3	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	486	10	3	3	7.2	Cc1cc(C)cc(Nc2ccc(CCC(=O)O)c(C(=O)N[C@H](CC(C)C)c3cc(C)cc(C)c3)c2)c1	10.1016/j.bmc.2010.03.028
	44444720	93792	0	None	-239	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	460	9	2	4	3.1	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2cccc(Br)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249953	93792	0	None	-239	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	460	9	2	4	3.1	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2cccc(Br)c2)cc1	10.1016/j.bmcl.2007.09.074
	11855870	145747	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	145747	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855870	145747	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	145747	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11269563	141078	0	None	-281	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	399	5	1	3	5.2	CC(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
	CHEMBL385126	141078	0	None	-281	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	399	5	1	3	5.2	CC(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
	10185382	64084	0	None	-30	5	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	500	7	1	7	4.6	COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	CHEMBL1813119	64084	0	None	-30	5	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	500	7	1	7	4.6	COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	9867899	201434	0	None	-97	3	Mouse	5.5	pKi	=	5.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	440	13	3	5	3.6	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](F)[C@@H]2CCSCCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	CHEMBL64072	201434	0	None	-97	3	Mouse	5.5	pKi	=	5.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	440	13	3	5	3.6	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](F)[C@@H]2CCSCCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	44303590	201222	0	None	-363	3	Mouse	5.5	pKi	=	5.5	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	468	14	3	7	2.6	COCCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	CHEMBL62779	201222	0	None	-363	3	Mouse	5.5	pKi	=	5.5	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	468	14	3	7	2.6	COCCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	21362867	106618	0	None	-128	4	Human	4.5	pKi	=	4.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	417	7	1	5	4.6	CSc1cccc(-c2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1	10.1016/s0960-894x(02)00518-8
	CHEMBL315974	106618	0	None	-128	4	Human	4.5	pKi	=	4.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	417	7	1	5	4.6	CSc1cccc(-c2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1	10.1016/s0960-894x(02)00518-8
	44269544	35026	0	None	-7762	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	359	11	2	3	3.2	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)Cc1ccccc1	10.1016/j.bmcl.2004.01.063
	CHEMBL14359	35026	0	None	-7762	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	359	11	2	3	3.2	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)Cc1ccccc1	10.1016/j.bmcl.2004.01.063
	118517488	153177	0	None	-56	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	CHEMBL3981554	153177	0	None	-56	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	118517361	152836	0	None	-218	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	CHEMBL3978590	152836	0	None	-218	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	57393339	69129	0	None	-57	2	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ncc(C(=O)O)s2)c1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933723	69129	0	None	-57	2	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ncc(C(=O)O)s2)c1	10.1016/j.bmcl.2011.10.109
	57393339	69129	0	None	-57	2	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ncc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933723	69129	0	None	-57	2	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ncc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
	44290312	178342	0	None	-87	2	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	421	11	2	3	5.0	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL47018	178342	0	None	-87	2	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	421	11	2	3	5.0	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2004.01.063
	72950089	150058	0	None	-1621	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL3955128	150058	0	None	-1621	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	21974331	126025	0	None	-5	4	Mouse	6.5	pKi	=	6.5	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	399	6	1	4	4.8	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL365243	126025	0	None	-5	4	Mouse	6.5	pKi	=	6.5	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	399	6	1	4	4.8	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
	10363130	100566	0	None	3	2	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL294585	100566	0	None	3	2	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	10185612	64082	0	None	-11	4	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	504	6	1	6	5.2	Cc1c(CC(=O)O)c2cc(Cl)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	CHEMBL1813117	64082	0	None	-11	4	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	504	6	1	6	5.2	Cc1c(CC(=O)O)c2cc(Cl)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	11338015	65787	0	None	-1	2	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	381	7	2	5	4.2	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(O)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL183983	65787	0	None	-1	2	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	381	7	2	5	4.2	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(O)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	44303967	201269	0	None	-	1	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	420	12	3	4	4.8	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL62987	201269	0	None	-	1	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	420	12	3	4	4.8	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCCC1	10.1016/s0960-894x(01)00359-6
	10294290	198370	0	None	-275	4	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	398	8	1	4	4.8	O=C(O)/C=C/c1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL595632	198370	0	None	-275	4	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	398	8	1	4	4.8	O=C(O)/C=C/c1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	50898361	56578	0	None	-2630	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	549	7	2	5	5.4	Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-c3c(C(=O)N(C)C)sc4c(C)cc(C)cc34)cc2)cc1	10.1016/j.bmcl.2010.11.118
	CHEMBL1644003	56578	0	None	-2630	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	549	7	2	5	5.4	Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-c3c(C(=O)N(C)C)sc4c(C)cc(C)cc34)cc2)cc1	10.1016/j.bmcl.2010.11.118
	44304474	201242	0	None	-91	5	Mouse	6.5	pKi	=	6.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCSCCC(=O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL62868	201242	0	None	-91	5	Mouse	6.5	pKi	=	6.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCSCCC(=O)O	10.1016/s0960-894x(01)00365-1
	10277744	64081	0	None	-12	7	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	6	1	6	4.9	Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	CHEMBL1813116	64081	0	None	-12	7	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	6	1	6	4.9	Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	10291963	84284	0	None	-199	6	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2011.10.109
	CHEMBL222715	84284	0	None	-199	6	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2011.10.109
	11476788	160727	0	None	-23	6	Human	5.5	pKi	=	5.5	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	463	5	1	5	4.4	CS(=O)(=O)c1cc(F)cc2c1c(C(=O)c1ccc(Cl)cc1)c1n2CCC[C@@H]1CC(=O)O	10.1016/j.bmcl.2008.03.015
	CHEMBL412070	160727	0	None	-23	6	Human	5.5	pKi	=	5.5	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	463	5	1	5	4.4	CS(=O)(=O)c1cc(F)cc2c1c(C(=O)c1ccc(Cl)cc1)c1n2CCC[C@@H]1CC(=O)O	10.1016/j.bmcl.2008.03.015
	92135977	152363	0	None	-275	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	CHEMBL3974652	152363	0	None	-275	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	11405770	137382	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	361	11	2	3	3.6	CCCCC[C@H](O)CC[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1021/jm049290a
	CHEMBL376347	137382	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	361	11	2	3	3.6	CCCCC[C@H](O)CC[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1021/jm049290a
	21362910	16744	0	None	-5	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	422	9	1	2	7.0	O=C(O)CCCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL125269	16744	0	None	-5	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	422	9	1	2	7.0	O=C(O)CCCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	57893867	74807	0	None	-12302	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	492	12	3	4	4.9	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccc3[nH]ccc3c2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036311	74807	0	None	-12302	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	492	12	3	4	4.9	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccc3[nH]ccc3c2)c1	10.1016/j.bmc.2012.04.008
	56658144	64475	0	None	1	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	7	2	5	3.8	CN1C[C@@H](COc2ccc(NC(=O)c3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	CHEMBL1819605	64475	0	None	1	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	7	2	5	3.8	CN1C[C@@H](COc2ccc(NC(=O)c3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	44349531	16388	0	None	-3	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	394	7	1	2	6.2	O=C(O)Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL123844	16388	0	None	-3	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	394	7	1	2	6.2	O=C(O)Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	21362849	167765	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	422	8	1	2	6.9	CC(Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)C(=O)O	10.1016/s0960-894x(03)00794-7
	CHEMBL434247	167765	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	422	8	1	2	6.9	CC(Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)C(=O)O	10.1016/s0960-894x(03)00794-7
	44269464	34254	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CC[C@@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	CHEMBL14286	34254	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CC[C@@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	118517489	143159	0	None	-44	2	Human	5.4	pKi	=	5.4	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	CHEMBL3900245	143159	0	None	-44	2	Human	5.4	pKi	=	5.4	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	44304417	200425	0	None	-138	4	Mouse	6.4	pKi	=	6.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	438	13	3	4	4.3	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	CHEMBL60894	200425	0	None	-138	4	Mouse	6.4	pKi	=	6.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	438	13	3	4	4.3	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	44303723	201246	0	None	-	1	Mouse	6.4	pKi	=	6.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	12	3	4	4.4	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL62885	201246	0	None	-	1	Mouse	6.4	pKi	=	6.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	12	3	4	4.4	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCC1	10.1016/s0960-894x(01)00359-6
	53358922	64099	0	None	-70	6	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	522	6	1	6	5.3	Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl	10.1016/j.bmc.2011.06.014
	CHEMBL1813276	64099	0	None	-70	6	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	522	6	1	6	5.3	Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl	10.1016/j.bmc.2011.06.014
	21362851	116404	0	None	-67	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	408	8	1	2	6.6	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL338388	116404	0	None	-67	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	408	8	1	2	6.6	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	10109445	84719	0	None	-537	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	365	10	2	4	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)s1	10.1021/jm049290a
	CHEMBL224970	84719	0	None	-537	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	365	10	2	4	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)s1	10.1021/jm049290a
	1883	3033	71	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	1916	3033	71	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	5280360	3033	71	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	913	3033	71	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	CHEMBL548	3033	71	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	DB00917	3033	71	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
	5283086	201619	19	None	-269	5	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	10.1016/s0960-894x(01)00359-6
	CHEMBL64804	201619	19	None	-269	5	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	10.1016/s0960-894x(01)00359-6
	10271490	165340	0	None	-29	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	386	9	1	2	5.8	Cc1cccc(CCCc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL424975	165340	0	None	-29	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	386	9	1	2	5.8	Cc1cccc(CCCc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	44320433	167380	0	None	-45	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1ccccc1CSCCc1ccccc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL431612	167380	0	None	-45	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1ccccc1CSCCc1ccccc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	24953283	197767	0	None	-426	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	467	6	2	3	6.5	C[C@@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
	CHEMBL591431	197767	0	None	-426	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	467	6	2	3	6.5	C[C@@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
	11855594	152447	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	152447	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855594	152447	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	152447	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11294166	76692	0	None	-213	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	461	6	2	5	4.3	CC(O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1016/j.bmcl.2006.02.062
	CHEMBL207203	76692	0	None	-213	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	461	6	2	5	4.3	CC(O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1016/j.bmcl.2006.02.062
	11294166	76692	0	None	-213	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	461	6	2	5	4.3	CC(O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
	CHEMBL207203	76692	0	None	-213	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	461	6	2	5	4.3	CC(O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
	22009003	122101	0	None	-436	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	468	8	2	3	6.7	Cc1cccc(C(O)/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	CHEMBL360290	122101	0	None	-436	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	468	8	2	3	6.7	Cc1cccc(C(O)/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	44304008	201551	0	None	-549	4	Mouse	5.4	pKi	=	5.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	410	11	3	6	2.4	O=C(O)CSCCCS[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)Cc1ccccc1	10.1016/s0960-894x(01)00364-x
	CHEMBL64542	201551	0	None	-549	4	Mouse	5.4	pKi	=	5.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	410	11	3	6	2.4	O=C(O)CSCCCS[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)Cc1ccccc1	10.1016/s0960-894x(01)00364-x
	44138108	183703	0	None	-12302	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	434	5	1	4	6.6	CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@@H]1CC(=O)O	10.1016/j.bmcl.2009.03.010
	CHEMBL483991	183703	0	None	-12302	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	434	5	1	4	6.6	CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@@H]1CC(=O)O	10.1016/j.bmcl.2009.03.010
	51039064	128679	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	5	5	3.7	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(O)cc2)cc1	nan
	CHEMBL3670657	128679	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	5	5	3.7	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(O)cc2)cc1	nan
	1883	3033	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
	1916	3033	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
	5280360	3033	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
	913	3033	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
	CHEMBL548	3033	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
	DB00917	3033	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
	1883	3033	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
	1916	3033	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
	5280360	3033	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
	913	3033	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
	CHEMBL548	3033	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
	DB00917	3033	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
	1883	3033	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
	1916	3033	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
	5280360	3033	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
	913	3033	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
	CHEMBL548	3033	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
	DB00917	3033	71	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
	44304124	102150	0	None	-	1	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	12	3	4	4.3	CC(C)CC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL304225	102150	0	None	-	1	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	12	3	4	4.3	CC(C)CC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	11855324	142073	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142073	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	11855324	142073	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142073	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	44269486	166289	0	None	-144	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CC[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	CHEMBL428524	166289	0	None	-144	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CC[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	138	3032	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	1882	3032	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	5280723	3032	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL495	3032	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	DB00770	3032	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	138	3032	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
	1882	3032	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
	5280723	3032	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
	CHEMBL495	3032	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
	DB00770	3032	84	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
	10183680	126645	0	None	-2	3	Mouse	6.4	pKi	=	6.4	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL365696	126645	0	None	-2	3	Mouse	6.4	pKi	=	6.4	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	11597294	165623	4	None	-489	8	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	4	1	2	5.7	O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21	10.1021/jm0603668
	CHEMBL426387	165623	4	None	-489	8	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	4	1	2	5.7	O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21	10.1021/jm0603668
	57391585	69124	0	None	-457	2	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	393	8	2	3	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933718	69124	0	None	-457	2	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	393	8	2	3	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1016/j.bmcl.2011.10.109
	57391585	69124	0	None	-457	2	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	393	8	2	3	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933718	69124	0	None	-457	2	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	393	8	2	3	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1016/j.bmc.2012.02.018
	10112486	16721	0	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1ccc(-c2ccccc2OCc2ccccc2)s1	10.1016/s0960-894x(03)00794-7
	CHEMBL125110	16721	0	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1ccc(-c2ccccc2OCc2ccccc2)s1	10.1016/s0960-894x(03)00794-7
	44390831	63306	0	None	-575	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	402	8	1	2	6.1	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccc(F)cc1	10.1016/j.bmcl.2004.11.051
	CHEMBL180089	63306	0	None	-575	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	402	8	1	2	6.1	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccc(F)cc1	10.1016/j.bmcl.2004.11.051
	44289969	100908	0	None	-17	2	Human	4.4	pKi	=	4.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	345	10	2	3	3.3	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1ccccc1	10.1016/j.bmcl.2004.01.063
	CHEMBL297139	100908	0	None	-17	2	Human	4.4	pKi	=	4.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	345	10	2	3	3.3	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1ccccc1	10.1016/j.bmcl.2004.01.063
	57398586	69133	0	None	-53	3	Mouse	7.4	pKi	=	7.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	422	9	2	7	3.0	Cc1ccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)o1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933727	69133	0	None	-53	3	Mouse	7.4	pKi	=	7.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	422	9	2	7	3.0	Cc1ccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)o1	10.1016/j.bmcl.2011.10.109
	44290262	177944	0	None	-10	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccc(Cl)cc2)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL46671	177944	0	None	-10	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccc(Cl)cc2)c1	10.1016/j.bmcl.2004.01.063
	44290272	100973	0	None	-6760	2	Human	4.4	pKi	=	4.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccccc2Cl)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL297578	100973	0	None	-6760	2	Human	4.4	pKi	=	4.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccccc2Cl)c1	10.1016/j.bmcl.2004.01.063
	44442327	94023	0	None	-147	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL251294	94023	0	None	-147	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	71462285	81468	0	None	-239	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	478	10	1	5	6.0	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCCn1cc2ccccc2c1C#N	10.1021/ml300191g
	CHEMBL2164608	81468	0	None	-239	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	478	10	1	5	6.0	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCCn1cc2ccccc2c1C#N	10.1021/ml300191g
	44303711	101882	0	None	18	3	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	13	3	4	4.4	CCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL303763	101882	0	None	18	3	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	13	3	4	4.4	CCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	24953285	199185	0	None	-53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	453	6	2	3	5.9	O=C(O)c1ccc(CNC(=O)c2c(Cl)sc(Cl)c2Cc2cccc(Cl)c2)cc1	10.1021/jm901771h
	CHEMBL601299	199185	0	None	-53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	453	6	2	3	5.9	O=C(O)c1ccc(CNC(=O)c2c(Cl)sc(Cl)c2Cc2cccc(Cl)c2)cc1	10.1021/jm901771h
	155520370	169908	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	7	1	5	5.2	CC(C)(C)c1ccc(CN(Cc2ccc3cc(C(=O)O)oc3c2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4448995	169908	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	7	1	5	5.2	CC(C)(C)c1ccc(CN(Cc2ccc3cc(C(=O)O)oc3c2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	56665068	64493	0	None	-3	4	Mouse	7.4	pKi	=	7.4	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	500	7	2	5	5.1	CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	CHEMBL1819622	64493	0	None	-3	4	Mouse	7.4	pKi	=	7.4	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	500	7	2	5	5.1	CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	10269242	155035	0	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	348	9	2	4	2.2	CC(C)CC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL404413	155035	0	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	348	9	2	4	2.2	CC(C)CC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	21974528	123931	0	None	-22	5	Mouse	6.4	pKi	=	6.4	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	441	6	1	5	4.6	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Cc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL363984	123931	0	None	-22	5	Mouse	6.4	pKi	=	6.4	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	441	6	1	5	4.6	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Cc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	44289922	162972	0	None	-954	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	339	13	2	3	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/j.bmcl.2004.01.063
	CHEMBL42027	162972	0	None	-954	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	339	13	2	3	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/j.bmcl.2004.01.063
	10227492	16718	0	None	-218	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	476	8	1	2	7.9	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2c(Cl)cccc2Cl)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL125087	16718	0	None	-218	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	476	8	1	2	7.9	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2c(Cl)cccc2Cl)c1	10.1016/s0960-894x(03)00794-7
	44349528	113302	0	None	-131	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	428	8	1	3	7.2	CC(CC(=O)O)c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL332446	113302	0	None	-131	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	428	8	1	3	7.2	CC(CC(=O)O)c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	59465601	149362	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.4	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3949271	149362	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.4	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	24953286	199699	0	None	-151	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	427	6	2	3	5.8	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1cccc(Cl)c1	10.1021/jm901771h
	CHEMBL604546	199699	0	None	-151	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	427	6	2	3	5.8	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1cccc(Cl)c1	10.1021/jm901771h
	54013831	145927	0	None	3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3922151	145927	0	None	3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	9845064	69006	0	None	-194	3	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	420	13	2	5	3.9	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)[C@@H]2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	CHEMBL1929528	69006	0	None	-194	3	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	420	13	2	5	3.9	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)[C@@H]2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	11395329	123329	0	None	-17	2	Mouse	5.3	pKi	=	5.3	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	395	8	1	5	4.5	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL362541	123329	0	None	-17	2	Mouse	5.3	pKi	=	5.3	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	395	8	1	5	4.5	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	9885106	84349	0	None	-2344	6	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1021/jm049290a
	CHEMBL223151	84349	0	None	-2344	6	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1021/jm049290a
	44304389	201463	0	None	-40	4	Mouse	7.3	pKi	=	7.3	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCSCC(=O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL64188	201463	0	None	-40	4	Mouse	7.3	pKi	=	7.3	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCSCC(=O)O	10.1016/s0960-894x(01)00365-1
	10168694	204626	0	None	-309	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	671	17	1	7	8.2	O=C(CCc1ccccc1-c1ccc(OCCCOc2cccc(CSCCc3ccccc3)c2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL87366	204626	0	None	-309	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	671	17	1	7	8.2	O=C(CCc1ccccc1-c1ccc(OCCCOc2cccc(CSCCc3ccccc3)c2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	12521	2166	0	None	-20892	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	72722131	2166	0	None	-20892	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	CHEMBL3918816	2166	0	None	-20892	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	1929	1575	46	None	-11	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	9890801	1575	46	None	-11	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	CHEMBL563646	1575	46	None	-11	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	DB12022	1575	46	None	-11	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
	10299717	64086	0	None	-144	6	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	6	1	6	4.9	Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21	10.1016/j.bmc.2011.06.014
	CHEMBL1813120	64086	0	None	-144	6	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	6	1	6	4.9	Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21	10.1016/j.bmc.2011.06.014
	59465588	142994	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	422	13	1	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3898887	142994	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	422	13	1	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465575	144534	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)c1	nan
	CHEMBL3911438	144534	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)c1	nan
	59465592	149170	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	386	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3947785	149170	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	386	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)OC)cc1	nan
	59465590	150412	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	406	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3957958	150412	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	406	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465584	150898	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	13	2	2	6.7	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCCO)cc1	nan
	CHEMBL3961847	150898	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	13	2	2	6.7	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCCO)cc1	nan
	11855325	144158	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144158	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855325	144158	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144158	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	57564500	150678	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959926	150678	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	12137443	84279	0	None	-5495	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	491	9	2	3	6.1	Cc1cc(Cl)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1021/jm049290a
	CHEMBL222677	84279	0	None	-5495	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	491	9	2	3	6.1	Cc1cc(Cl)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1021/jm049290a
	11224239	64473	0	None	-1	4	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	7	2	5	3.8	CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	CHEMBL1819603	64473	0	None	-1	4	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	7	2	5	3.8	CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	11282034	66297	0	None	-13	3	Mouse	5.3	pKi	=	5.3	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	437	11	1	5	5.6	CCCCOc1ccc(C(=O)n2c(C)c(CCCCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL185277	66297	0	None	-13	3	Mouse	5.3	pKi	=	5.3	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	437	11	1	5	5.6	CCCCOc1ccc(C(=O)n2c(C)c(CCCCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	46887240	8666	0	None	-13489	3	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	472	10	3	3	6.9	Cc1cccc(Nc2ccc(CCC(=O)O)c(C(=O)N[C@H](CC(C)C)c3cc(C)cc(C)c3)c2)c1	10.1016/j.bmc.2010.03.028
	CHEMBL1096382	8666	0	None	-13489	3	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	472	10	3	3	6.9	Cc1cccc(Nc2ccc(CCC(=O)O)c(C(=O)N[C@H](CC(C)C)c3cc(C)cc(C)c3)c2)c1	10.1016/j.bmc.2010.03.028
	52945419	16357	0	None	-478	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	772	16	4	6	10.7	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(O)c1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237296	16357	0	None	-478	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	772	16	4	6	10.7	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(O)c1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	56672018	64476	0	None	-6	3	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	446	7	1	5	3.9	CN1C[C@@H](COc2ccc(C(=O)N(C)c3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	CHEMBL1819606	64476	0	None	-6	3	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	446	7	1	5	3.9	CN1C[C@@H](COc2ccc(C(=O)N(C)c3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
	44303709	201510	0	None	-870	3	Mouse	5.3	pKi	=	5.3	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	470	13	3	7	3.3	CSCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	CHEMBL64338	201510	0	None	-870	3	Mouse	5.3	pKi	=	5.3	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	470	13	3	7	3.3	CSCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	59465581	143580	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3903611	143580	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	44455236	95031	0	None	-53	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	373	11	2	3	3.8	CCCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL257217	95031	0	None	-53	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	373	11	2	3	3.8	CCCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	21974448	66629	0	None	-53	4	Mouse	6.3	pKi	=	6.3	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	429	8	1	5	4.7	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCOc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL186735	66629	0	None	-53	4	Mouse	6.3	pKi	=	6.3	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	429	8	1	5	4.7	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCOc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
	11155228	65775	0	None	-1778	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	452	8	1	2	7.2	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	CHEMBL183919	65775	0	None	-1778	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	452	8	1	2	7.2	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
	44419347	82363	0	None	-1778	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	452	8	1	2	7.2	Cc1ccc(OCc2c(Cl)cccc2Cl)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL217988	82363	0	None	-1778	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	452	8	1	2	7.2	Cc1ccc(OCc2c(Cl)cccc2Cl)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
	10298293	93733	0	None	-426	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	460	9	2	4	3.1	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(Br)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249538	93733	0	None	-426	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	460	9	2	4	3.1	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(Br)c2)cc1	10.1016/j.bmcl.2007.09.074
	52944193	16356	0	None	-63	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237295	16356	0	None	-63	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	21362905	170741	0	None	-8	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	428	8	1	3	6.9	CC(Cc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1)C(=O)O	10.1016/s0960-894x(03)00794-7
	CHEMBL446098	170741	0	None	-8	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	428	8	1	3	6.9	CC(Cc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1)C(=O)O	10.1016/s0960-894x(03)00794-7
	58932683	74937	0	None	-354	3	Mouse	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1	10.1016/j.bmc.2012.04.008
	CHEMBL2037289	74937	0	None	-354	3	Mouse	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1	10.1016/j.bmc.2012.04.008
	44444716	154299	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	484	12	1	3	5.4	CC(CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1)Cc1cccc(CCc2ccccc2)c1	10.1016/j.bmcl.2007.09.074
	CHEMBL400447	154299	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	484	12	1	3	5.4	CC(CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1)Cc1cccc(CCc2ccccc2)c1	10.1016/j.bmcl.2007.09.074
	10295421	93763	0	None	-316	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	416	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249744	93763	0	None	-316	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	416	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.09.074
	44234032	147392	0	None	-81	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrDisplacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hr	ChEMBL	415	8	1	4	5.0	O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1	10.1021/acs.jmedchem.6b00871
	CHEMBL3933704	147392	0	None	-81	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrDisplacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hr	ChEMBL	415	8	1	4	5.0	O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1	10.1021/acs.jmedchem.6b00871
	11165749	165406	0	None	-20	3	Mouse	5.2	pKi	=	5.2	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	409	9	1	5	4.8	CCCCOc1ccc(C(=O)n2c(C)c(CCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL425167	165406	0	None	-20	3	Mouse	5.2	pKi	=	5.2	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	409	9	1	5	4.8	CCCCOc1ccc(C(=O)n2c(C)c(CCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	44520990	198171	0	None	-6	3	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	410	6	2	4	5.3	Cc1ccc(/C=C/C(=O)O)c(OCCC2(C)CCc3c(C)c(O)c(C)c(C)c3O2)c1	10.1016/j.bmc.2009.08.007
	CHEMBL594423	198171	0	None	-6	3	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	410	6	2	4	5.3	Cc1ccc(/C=C/C(=O)O)c(OCCC2(C)CCc3c(C)c(O)c(C)c(C)c3O2)c1	10.1016/j.bmc.2009.08.007
	11855867	145450	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	145450	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855867	145450	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	145450	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	44304403	168531	0	None	-16	4	Mouse	7.2	pKi	=	7.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	420	12	3	4	3.8	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](F)[C@@H]2C/C=C/CCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	CHEMBL439934	168531	0	None	-16	4	Mouse	7.2	pKi	=	7.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	420	12	3	4	3.8	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](F)[C@@H]2C/C=C/CCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
	44290314	173402	0	None	-5754	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	403	10	2	4	3.9	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1ccc(C(F)(F)F)o1	10.1016/j.bmcl.2004.01.063
	CHEMBL45418	173402	0	None	-5754	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	403	10	2	4	3.9	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1ccc(C(F)(F)F)o1	10.1016/j.bmcl.2004.01.063
	44320272	204539	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	507	10	1	5	5.9	O=C(Cc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL86886	204539	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	507	10	1	5	5.9	O=C(Cc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	24952929	2517	37	None	-9332	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
	4041	2517	37	None	-9332	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
	CHEMBL597997	2517	37	None	-9332	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
	10295336	199761	0	None	-53	4	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	415	8	1	3	4.7	O=C(O)/C=C/c1ccc(CN2CCCC2=O)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL604897	199761	0	None	-53	4	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	415	8	1	3	4.7	O=C(O)/C=C/c1ccc(CN2CCCC2=O)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	44290266	161159	0	None	-8	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	353	12	3	4	2.3	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)N1C/C=C/CCCC(=O)O	10.1016/j.bmcl.2004.01.063
	CHEMBL413509	161159	0	None	-8	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	353	12	3	4	2.3	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)N1C/C=C/CCCC(=O)O	10.1016/j.bmcl.2004.01.063
	44394380	124909	0	None	-6	4	Mouse	7.2	pKi	=	7.2	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	457	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2COc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL364593	124909	0	None	-6	4	Mouse	7.2	pKi	=	7.2	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	457	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2COc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	44442337	93573	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	381	8	1	2	5.0	C/C(=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1)CC1CCCC1	10.1016/j.bmcl.2007.05.025
	CHEMBL248678	93573	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	381	8	1	2	5.0	C/C(=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1)CC1CCCC1	10.1016/j.bmcl.2007.05.025
	44442331	94054	0	None	-15	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251505	94054	0	None	-15	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	10278907	64087	0	None	-138	3	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	504	6	1	6	5.2	Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl	10.1016/j.bmc.2011.06.014
	CHEMBL1813121	64087	0	None	-138	3	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	504	6	1	6	5.2	Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl	10.1016/j.bmc.2011.06.014
	59465570	142727	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	392	13	2	2	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3896693	142727	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	392	13	2	2	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)O)cc1	nan
	134147021	149492	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	414	13	2	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)s1	nan
	CHEMBL3950412	149492	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	414	13	2	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)s1	nan
	10204257	93735	0	None	-104	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	450	9	2	4	3.4	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249540	93735	0	None	-104	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	450	9	2	4	3.4	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2007.09.074
	44219292	112090	30	None	-204	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrDisplacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hr	ChEMBL	431	8	1	4	5.5	O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.6b00871
	CHEMBL3301604	112090	30	None	-204	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrDisplacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hr	ChEMBL	431	8	1	4	5.5	O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.6b00871
	57400087	70958	0	None	-2	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	413	8	2	3	4.0	O=C(O)CCc1cccc(N2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1957431	70958	0	None	-2	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	413	8	2	3	4.0	O=C(O)CCc1cccc(N2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)c1	10.1016/j.bmc.2012.02.018
	57893916	74805	0	None	-1288	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	454	12	2	5	3.8	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccccn2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036309	74805	0	None	-1288	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	454	12	2	5	3.8	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccccn2)c1	10.1016/j.bmc.2012.04.008
	56672019	64483	0	None	-7	4	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	460	7	2	5	4.5	Cc1cc(CC(=O)O)cc(NC(=O)c2ccc(OC[C@@H]3CN(C)c4ccccc4O3)cc2C)c1	10.1016/j.bmc.2011.08.007
	CHEMBL1819612	64483	0	None	-7	4	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	460	7	2	5	4.5	Cc1cc(CC(=O)O)cc(NC(=O)c2ccc(OC[C@@H]3CN(C)c4ccccc4O3)cc2C)c1	10.1016/j.bmc.2011.08.007
	8541	2899	1	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	9824353	2899	1	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL292964	2899	1	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
	8541	2899	1	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Binding affinity to mouse EP2 receptor by competitive binding assayBinding affinity to mouse EP2 receptor by competitive binding assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/jm9018756
	9824353	2899	1	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Binding affinity to mouse EP2 receptor by competitive binding assayBinding affinity to mouse EP2 receptor by competitive binding assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/jm9018756
	CHEMBL292964	2899	1	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Binding affinity to mouse EP2 receptor by competitive binding assayBinding affinity to mouse EP2 receptor by competitive binding assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/jm9018756
	8541	2899	1	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/j.bmc.2011.12.009
	9824353	2899	1	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/j.bmc.2011.12.009
	CHEMBL292964	2899	1	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/j.bmc.2011.12.009
	10221497	93705	0	None	-91	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	382	9	2	4	2.4	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249342	93705	0	None	-91	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	382	9	2	4	2.4	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.09.074
	10272306	154298	0	None	-173	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	400	9	2	4	2.5	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(F)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL400446	154298	0	None	-173	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	400	9	2	4	2.5	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(F)c2)cc1	10.1016/j.bmcl.2007.09.074
	71452690	78215	0	None	15	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	400	9	1	4	5.1	c1ccc(CCSCc2ccc(-c3ccccc3CCc3nnn[nH]3)cc2)cc1	10.1016/s0960-894x(02)00518-8
	CHEMBL2112332	78215	0	None	15	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	400	9	1	4	5.1	c1ccc(CCSCc2ccc(-c3ccccc3CCc3nnn[nH]3)cc2)cc1	10.1016/s0960-894x(02)00518-8
	52950151	16360	0	None	3	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1.Cc1cccc(C/C=C/c2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237299	16360	0	None	3	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1.Cc1cccc(C/C=C/c2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	22008967	82736	0	None	-2691	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	439	8	1	5	4.5	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1	10.1016/j.bmcl.2006.08.025
	CHEMBL218228	82736	0	None	-2691	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	439	8	1	5	4.5	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1	10.1016/j.bmcl.2006.08.025
	22008966	82737	0	None	-2691	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	439	8	1	5	4.5	COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1	10.1016/j.bmcl.2006.08.025
	CHEMBL218229	82737	0	None	-2691	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	439	8	1	5	4.5	COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1	10.1016/j.bmcl.2006.08.025
	13230981	34841	0	None	-1122	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	339	13	2	3	3.5	CCCCCC(O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	CHEMBL14334	34841	0	None	-1122	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	339	13	2	3	3.5	CCCCCC(O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
	10348006	74940	0	None	-338	3	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	569	10	2	8	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2037292	74940	0	None	-338	3	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	569	10	2	8	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	52943000	16358	0	None	-26	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	740	16	2	4	11.2	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1ccccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237297	16358	0	None	-26	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	740	16	2	4	11.2	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1ccccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	10319835	69025	0	None	-16982	3	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	417	13	2	3	4.9	CCCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	CHEMBL1929547	69025	0	None	-16982	3	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	417	13	2	3	4.9	CCCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	44520991	198020	0	None	-7	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	426	7	2	5	5.0	COc1ccc(/C=C/C(=O)O)c(OCCC2(C)CCc3c(C)c(O)c(C)c(C)c3O2)c1	10.1016/j.bmc.2009.08.007
	CHEMBL593260	198020	0	None	-7	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	426	7	2	5	5.0	COc1ccc(/C=C/C(=O)O)c(OCCC2(C)CCc3c(C)c(O)c(C)c(C)c3O2)c1	10.1016/j.bmc.2009.08.007
	44289977	162209	0	None	-478	2	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	413	10	2	3	4.3	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL417171	162209	0	None	-478	2	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	413	10	2	3	4.3	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
	12003887	70955	0	None	-776	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	411	11	2	4	3.4	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(Cl)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1957308	70955	0	None	-776	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	411	11	2	4	3.4	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(Cl)c1	10.1016/j.bmc.2012.02.018
	67078970	128677	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	416	6	3	5	4.4	COC(=O)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(O)cc2)cc1	nan
	CHEMBL3670655	128677	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	416	6	3	5	4.4	COC(=O)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(O)cc2)cc1	nan
	59465571	145752	0	None	21	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	386	12	2	3	5.6	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3920796	145752	0	None	21	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	386	12	2	3	5.6	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	59465600	151166	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.3	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3964261	151166	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.3	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	21362845	106420	0	None	-630	4	Human	4.2	pKi	=	4.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	556	7	1	5	7.3	O=C(/C=C/c1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	CHEMBL314616	106420	0	None	-630	4	Human	4.2	pKi	=	4.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	556	7	1	5	7.3	O=C(/C=C/c1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
	52943002	16362	0	None	-2	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	716	14	2	4	11.1	Cc1cccc(/C=C\Cc2ccccc2C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237301	16362	0	None	-2	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	716	14	2	4	11.1	Cc1cccc(/C=C\Cc2ccccc2C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	67245477	144350	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	428	13	1	4	7.0	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)s1	nan
	CHEMBL3909989	144350	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	428	13	1	4	7.0	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)s1	nan
	44289921	163819	0	None	-9332	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	365	11	2	3	3.9	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)CC1CCCCC1	10.1016/j.bmcl.2004.01.063
	CHEMBL42129	163819	0	None	-9332	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	365	11	2	3	3.9	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)CC1CCCCC1	10.1016/j.bmcl.2004.01.063
	57893891	74809	0	None	-1995	2	Mouse	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	510	12	2	6	5.0	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2nc3ccccc3s2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL2036313	74809	0	None	-1995	2	Mouse	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	510	12	2	6	5.0	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2nc3ccccc3s2)c1	10.1016/j.bmc.2012.04.008
	24952929	2517	37	None	-11481	5	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
	4041	2517	37	None	-11481	5	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
	CHEMBL597997	2517	37	None	-11481	5	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
	1892	736	15	None	-2	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
	25886893	736	15	None	-2	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
	CHEMBL1628262	736	15	None	-2	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
	44304181	201582	0	None	12	2	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	394	13	3	4	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64663	201582	0	None	12	2	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	394	13	3	4	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	9965922	63546	0	None	-724	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	294	5	2	2	4.1	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1O	10.1016/j.bmcl.2004.11.051
	CHEMBL180389	63546	0	None	-724	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	294	5	2	2	4.1	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1O	10.1016/j.bmcl.2004.11.051
	24765153	183947	0	None	-11481	8	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	434	5	1	4	6.6	CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@H]1CC(=O)O	10.1016/j.bmcl.2009.03.010
	CHEMBL484778	183947	0	None	-11481	8	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	434	5	1	4	6.6	CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@H]1CC(=O)O	10.1016/j.bmcl.2009.03.010
	9910141	100408	0	None	-1513	3	Mouse	5.1	pKi	=	5.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	422	11	4	6	2.7	Cc1cc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCSCCCC(=O)O)ccc1O	10.1016/s0960-894x(01)00365-1
	CHEMBL293647	100408	0	None	-1513	3	Mouse	5.1	pKi	=	5.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	422	11	4	6	2.7	Cc1cc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCSCCCC(=O)O)ccc1O	10.1016/s0960-894x(01)00365-1
	118517485	142218	0	None	-50	2	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	CHEMBL3892492	142218	0	None	-50	2	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	24952580	198878	0	None	-575	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	467	6	2	3	6.5	C[C@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
	CHEMBL599052	198878	0	None	-575	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	467	6	2	3	6.5	C[C@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
	10452108	93574	0	None	-25	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	375	7	1	2	4.6	C/C(=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1)c1ccccc1	10.1016/j.bmcl.2007.05.025
	CHEMBL248679	93574	0	None	-25	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	375	7	1	2	4.6	C/C(=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1)c1ccccc1	10.1016/j.bmcl.2007.05.025
	44304388	201462	0	None	-151	5	Mouse	7.1	pKi	=	7.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL64187	201462	0	None	-151	5	Mouse	7.1	pKi	=	7.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O	10.1016/s0960-894x(01)00365-1
	11440167	84294	0	None	-75	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	371	9	2	3	3.4	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)CCC2CCC2)cc1	10.1021/jm049290a
	CHEMBL222782	84294	0	None	-75	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	371	9	2	3	3.4	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)CCC2CCC2)cc1	10.1021/jm049290a
	44444722	93821	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	402	11	2	4	3.5	CCCC1(C(O)CCCN2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.09.074
	CHEMBL250153	93821	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	402	11	2	4	3.5	CCCC1(C(O)CCCN2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.09.074
	52945294	16370	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	800	18	2	6	11.3	COc1cc(/C=C\Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1.COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237317	16370	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	800	18	2	6	11.3	COc1cc(/C=C\Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1.COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	52945294	16370	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	800	18	2	6	11.3	COc1cc(/C=C\Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1.COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	CHEMBL1237317	16370	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	800	18	2	6	11.3	COc1cc(/C=C\Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1.COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	10111602	82815	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	400	9	1	3	5.6	COc1cc(/C=C/Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	CHEMBL218626	82815	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	400	9	1	3	5.6	COc1cc(/C=C/Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	22990263	16614	0	None	-4	3	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	292	3	1	1	4.8	O=C(O)/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL124574	16614	0	None	-4	3	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	292	3	1	1	4.8	O=C(O)/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(03)00794-7
	10410111	102368	0	None	-398	3	Mouse	6.1	pKi	=	6.1	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	CHEMBL305568	102368	0	None	-398	3	Mouse	6.1	pKi	=	6.1	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	44304009	100268	0	None	-1479	3	Mouse	5.1	pKi	=	5.1	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	482	15	3	7	3.3	CCCOCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	CHEMBL292717	100268	0	None	-1479	3	Mouse	5.1	pKi	=	5.1	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	482	15	3	7	3.3	CCCOCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
	11210487	63963	0	None	177	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	356	7	1	2	5.5	O=C(O)/C=C/c1ccccc1/C=C/c1ccccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL181035	63963	0	None	177	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	356	7	1	2	5.5	O=C(O)/C=C/c1ccccc1/C=C/c1ccccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	16725337	149069	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	149069	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	16725337	149069	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	149069	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	24953625	199847	0	None	-323	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	461	6	2	3	6.2	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1cccc(C(F)(F)F)c1	10.1021/jm901771h
	CHEMBL605330	199847	0	None	-323	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	461	6	2	3	6.2	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1cccc(C(F)(F)F)c1	10.1021/jm901771h
	10302378	82367	0	None	-6606	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	539	9	1	5	6.6	O=C(/C=C/c1ccccc1Cc1ccc2cc(OCc3ccccc3)ccc2c1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	CHEMBL217991	82367	0	None	-6606	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	539	9	1	5	6.6	O=C(/C=C/c1ccccc1Cc1ccc2cc(OCc3ccccc3)ccc2c1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	22009006	141032	0	None	-1584	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	409	7	1	4	4.5	O=C(/C=C/c1ccccc1/C=C/Cc1ccccc1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	CHEMBL384878	141032	0	None	-1584	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	409	7	1	4	4.5	O=C(/C=C/c1ccccc1/C=C/Cc1ccccc1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	9953337	141128	0	None	-1584	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	409	7	1	4	4.5	O=C(/C=C/c1ccccc1C/C=C/c1ccccc1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	CHEMBL385396	141128	0	None	-1584	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	409	7	1	4	4.5	O=C(/C=C/c1ccccc1C/C=C/c1ccccc1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	25003075	6760	12	None	-28183	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting	ChEMBL	478	6	2	3	5.8	O=C(O)c1ccc(C2(NC(=O)c3cccc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1	10.1016/j.bmcl.2010.04.065
	CHEMBL1084009	6760	12	None	-28183	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting	ChEMBL	478	6	2	3	5.8	O=C(O)c1ccc(C2(NC(=O)c3cccc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1	10.1016/j.bmcl.2010.04.065
	10247632	77637	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL2096894	77637	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	10178073	16382	0	None	-1148	4	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	384	8	1	2	5.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/s0960-894x(03)00794-7
	CHEMBL123794	16382	0	None	-1148	4	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	384	8	1	2	5.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/s0960-894x(03)00794-7
	9944231	17851	0	None	-10	4	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	302	5	1	1	5.0	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL126472	17851	0	None	-10	4	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	302	5	1	1	5.0	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	10178073	16382	0	None	-1148	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL123794	16382	0	None	-1148	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	12112238	117568	0	None	-10	4	Human	6.1	pKi	=	6.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	406	7	1	2	6.7	O=C(O)/C=C/c1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	CHEMBL340501	117568	0	None	-10	4	Human	6.1	pKi	=	6.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	406	7	1	2	6.7	O=C(O)/C=C/c1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
	44444715	93764	0	None	-25	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	450	12	2	4	3.7	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(CCC3CC3)c2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249745	93764	0	None	-25	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	450	12	2	4	3.7	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(CCC3CC3)c2)cc1	10.1016/j.bmcl.2007.09.074
	57398585	69127	0	None	-6	2	Mouse	7.1	pKi	=	7.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	414	9	2	5	3.2	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)cs2)c1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933721	69127	0	None	-6	2	Mouse	7.1	pKi	=	7.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	414	9	2	5	3.2	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)cs2)c1	10.1016/j.bmcl.2011.10.109
	57398585	69127	0	None	-6	2	Mouse	7.1	pKi	=	7.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	414	9	2	5	3.2	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933721	69127	0	None	-6	2	Mouse	7.1	pKi	=	7.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	414	9	2	5	3.2	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	56834112	69005	0	None	-1071	2	Mouse	5.1	pKi	=	5.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	421	13	2	5	2.9	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	CHEMBL1929527	69005	0	None	-1071	2	Mouse	5.1	pKi	=	5.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	421	13	2	5	2.9	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
	44290271	178470	0	None	-204	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2cccc(Cl)c2)c1	10.1016/j.bmcl.2004.01.063
	CHEMBL47138	178470	0	None	-204	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2cccc(Cl)c2)c1	10.1016/j.bmcl.2004.01.063
	52944193	16356	0	None	-63	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237295	16356	0	None	-63	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	44419374	82582	0	None	-95	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL218123	82582	0	None	-95	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
	44419379	137338	0	None	-95	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL376053	137338	0	None	-95	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
	44320388	204682	0	None	-56	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	536	11	2	6	5.8	Cc1cccc(OCCCOc2ccc(-c3ccccc3CNC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	CHEMBL87797	204682	0	None	-56	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	536	11	2	6	5.8	Cc1cccc(OCCCOc2ccc(-c3ccccc3CNC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
	9954562	83722	0	None	-478	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	433	6	1	4	5.0	O=C(/C=C/c1ccccc1Cc1ccc2ccccc2c1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	CHEMBL220802	83722	0	None	-478	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	433	6	1	4	5.0	O=C(/C=C/c1ccccc1Cc1ccc2ccccc2c1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
	138	3032	84	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	1882	3032	84	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	5280723	3032	84	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	CHEMBL495	3032	84	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	DB00770	3032	84	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	52945423	16364	0	None	-33	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	824	18	2	6	11.6	CC(=O)c1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1.CC(=O)c1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2004.11.051
	CHEMBL1237303	16364	0	None	-33	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	824	18	2	6	11.6	CC(=O)c1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1.CC(=O)c1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2004.11.051
	22009008	82744	0	None	-5495	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	545	11	1	6	6.1	COc1cc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	CHEMBL218280	82744	0	None	-5495	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	545	11	1	6	6.1	COc1cc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	22009004	141219	0	None	-2884	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	545	11	1	6	6.1	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	CHEMBL385955	141219	0	None	-2884	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	545	11	1	6	6.1	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
	132836	59383	20	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL1722929	59383	20	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	44442332	94091	0	None	-3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	341	9	1	2	4.2	CCCC/C=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251709	94091	0	None	-3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	341	9	1	2	4.2	CCCC/C=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	44393680	66013	0	None	-4	2	Mouse	5.1	pKi	=	5.1	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	367	7	1	5	4.2	CCCCOc1ccc(C(=O)n2cc(C(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	CHEMBL185087	66013	0	None	-4	2	Mouse	5.1	pKi	=	5.1	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	367	7	1	5	4.2	CCCCOc1ccc(C(=O)n2cc(C(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
	84973026	128686	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	441	7	4	4	4.7	COc1ccc(-c2cc(-c3ccccc3)[nH]c2C(=O)Nc2cccc(CC(=O)NO)c2)cc1	nan
	CHEMBL3670664	128686	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	441	7	4	4	4.7	COc1ccc(-c2cc(-c3ccccc3)[nH]c2C(=O)Nc2cccc(CC(=O)NO)c2)cc1	nan
	57894063	74815	0	None	-5	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	524	11	2	7	4.8	COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	CHEMBL2036319	74815	0	None	-5	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	524	11	2	7	4.8	COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	56835070	69128	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmcl.2011.10.109
	CHEMBL1933722	69128	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmcl.2011.10.109
	56835070	69128	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933722	69128	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	56835070	69128	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL1933722	69128	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.04.008
	84973025	128683	3	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	5	5	3.7	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccc(O)cc3)cc2-c2ccoc2)cc1	nan
	CHEMBL3670661	128683	3	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	5	5	3.7	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccc(O)cc3)cc2-c2ccoc2)cc1	nan
	21974374	126725	0	None	-1	5	Mouse	7.1	pKi	=	7.1	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	455	6	1	5	5.0	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2CCc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	CHEMBL365829	126725	0	None	-1	5	Mouse	7.1	pKi	=	7.1	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	455	6	1	5	5.0	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2CCc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
	44304334	199891	0	None	-45	5	Mouse	7.0	pKi	=	7.0	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCCCC(=O)O	10.1016/s0960-894x(01)00365-1
	CHEMBL60555	199891	0	None	-45	5	Mouse	7.0	pKi	=	7.0	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCCCC(=O)O	10.1016/s0960-894x(01)00365-1
	57396659	70957	0	None	-114	3	Mouse	7.0	pKi	=	7.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	431	9	2	5	4.0	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ccc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1957430	70957	0	None	-114	3	Mouse	7.0	pKi	=	7.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	431	9	2	5	4.0	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ccc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
	44304199	100350	0	None	-	1	Mouse	7.0	pKi	=	7.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2C/C=C/CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL293242	100350	0	None	-	1	Mouse	7.0	pKi	=	7.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2C/C=C/CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	44444719	93791	0	None	-67	2	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	382	9	2	4	2.4	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249952	93791	0	None	-67	2	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	382	9	2	4	2.4	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.09.074
	10273914	197990	0	None	-70	3	Mouse	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	424	9	1	3	6.1	O=C(O)/C=C/c1ccc(COc2ccccc2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	CHEMBL593041	197990	0	None	-70	3	Mouse	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	424	9	1	3	6.1	O=C(O)/C=C/c1ccc(COc2ccccc2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
	46230201	198932	0	None	-436	3	Mouse	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	453	9	2	3	5.9	C[C@H](NC(=O)c1cc(COc2ccccc2)ccc1CCC(=O)O)c1cccc2ccccc12	10.1016/j.bmc.2009.11.023
	CHEMBL599355	198932	0	None	-436	3	Mouse	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	453	9	2	3	5.9	C[C@H](NC(=O)c1cc(COc2ccccc2)ccc1CCC(=O)O)c1cccc2ccccc12	10.1016/j.bmc.2009.11.023
	118517485	142218	0	None	-50	2	Human	5.0	pKi	=	5.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	CHEMBL3892492	142218	0	None	-50	2	Human	5.0	pKi	=	5.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	118517490	152621	0	None	-125	2	Human	5.0	pKi	=	5.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	CHEMBL3976710	152621	0	None	-125	2	Human	5.0	pKi	=	5.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	9865111	63534	0	None	-14	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	388	10	1	2	5.8	Cc1cccc(CCCc2ccccc2CCC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL180343	63534	0	None	-14	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	388	10	1	2	5.8	Cc1cccc(CCCc2ccccc2CCC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	44419350	83727	0	None	-14	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	388	10	1	2	5.8	Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)O)c1	10.1016/j.bmcl.2006.08.025
	CHEMBL220820	83727	0	None	-14	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	388	10	1	2	5.8	Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)O)c1	10.1016/j.bmcl.2006.08.025
	118517359	143863	0	None	-114	2	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	143863	0	None	-114	2	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	10116114	125365	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	CHEMBL364841	125365	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
	10116114	125365	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.08.007
	CHEMBL364841	125365	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.08.007
	44390806	63747	0	None	-24	3	Human	6.0	pKi	=	6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	386	8	1	2	5.9	Cc1cccc(C2CC2c2ccccc2CCC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	CHEMBL180752	63747	0	None	-24	3	Human	6.0	pKi	=	6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	386	8	1	2	5.9	Cc1cccc(C2CC2c2ccccc2CCC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
	1883	3033	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	1883	3033	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	1916	3033	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	1916	3033	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	5280360	3033	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	5280360	3033	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	913	3033	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	913	3033	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	CHEMBL548	3033	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	CHEMBL548	3033	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	DB00917	3033	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	DB00917	3033	71	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	1883	3033	71	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
	1916	3033	71	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
	5280360	3033	71	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
	913	3033	71	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
	CHEMBL548	3033	71	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
	DB00917	3033	71	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
	1883	3033	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
	1883	3033	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	1916	3033	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
	1916	3033	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	5280360	3033	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
	5280360	3033	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	913	3033	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
	913	3033	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	CHEMBL548	3033	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
	CHEMBL548	3033	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	DB00917	3033	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
	DB00917	3033	71	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	138	3032	84	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	1882	3032	84	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	5280723	3032	84	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	CHEMBL495	3032	84	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	DB00770	3032	84	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	None	214275	0	3H-PGE2	-66	3	Mouse	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	350	11	3	3	4.1	CCCCCC(C=CC1C(CC2C1CC(=C2)CCCCC(=O)O)O)O	None
	5090	214646	0	Functional	-1348	31	Dog	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3	None
	5090	214646	0	Functional	-35	31	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3	None
	5311035	97354	27	3H-PGE2	4	9	Mouse	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	None
	CHEMBL271896	97354	27	3H-PGE2	4	9	Mouse	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	None
	1883	3033	71	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1916	3033	71	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	5280360	3033	71	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	913	3033	71	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	CHEMBL548	3033	71	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	DB00917	3033	71	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1917	914	0	3H-PGE2	-22	9	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	5311044	914	0	3H-PGE2	-22	9	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	631	914	0	3H-PGE2	-22	9	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	CHEMBL160629	914	0	3H-PGE2	-22	9	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	89077401	214273	0	3H-PGE2	-144	12	Mouse	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	360	8	3	3	3.5	CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O	None
	133126726	214274	0	3H-PGE2	-151	14	Mouse	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	350	10	3	3	4.1	CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O	None
	24868263	214274	0	3H-PGE2	-151	14	Mouse	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	350	10	3	3	4.1	CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O	None
	1440	1996	116	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	1909	1996	116	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	3715	1996	116	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	CHEMBL6	1996	116	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	DB00328	1996	116	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	None	214272	0	3H-PGE2	-9	5	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	366	12	2	3	5.2	CCCCCC(C=CC1CC2CC(C1CC=CCCCC(=O)O)S2)O	None
	None	214278	0	3H-PGE2	-2	3	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	512	11	2	4	4.6	C1CC2C(C(C1O2)CC=CCCCC(=O)O)C=CC(COC3=CC=C(C=C3)I)O	None
	1928	314	0	3H-PGE2	-3	3	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	None
	5310998	314	0	3H-PGE2	-3	3	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	None
	1817	2506	60	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	1936	2506	60	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	5282381	2506	60	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	CHEMBL606	2506	60	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	DB00929	2506	60	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	1440	1996	116	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	1440	1996	116	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	1909	1996	116	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	1909	1996	116	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	3715	1996	116	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	3715	1996	116	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	CHEMBL6	1996	116	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	CHEMBL6	1996	116	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	DB00328	1996	116	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	DB00328	1996	116	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	119461	317	66	3H-PGE2	1	10	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	None
	1896	317	66	3H-PGE2	1	10	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	None
	CHEMBL1317823	317	66	3H-PGE2	1	10	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	None
	5090	214646	0	Functional	-35	31	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3	None
	5090	214646	0	Functional	-35	31	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3	None
	5077	3522	72	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
	7552	3522	72	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
	9913767	3522	72	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
	CHEMBL238804	3522	72	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
	DB11362	3522	72	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
	1884	3034	46	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	5280363	3034	46	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	912	3034	46	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	CHEMBL815	3034	46	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	DB12789	3034	46	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	138107701	186881	39	None	-5	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	5311181	186881	39	None	-5	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	CHEMBL494	186881	39	None	-5	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	138107701	186881	39	None	-5	15	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	5311181	186881	39	None	-5	15	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	CHEMBL494	186881	39	None	-5	15	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	1917	914	0	None	-22	9	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	5311044	914	0	None	-22	9	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	631	914	0	None	-22	9	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	CHEMBL160629	914	0	None	-22	9	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
	138107701	186881	39	None	-5	15	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	5311181	186881	39	None	-5	15	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	CHEMBL494	186881	39	None	-5	15	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
	1884	3034	46	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	5280363	3034	46	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	912	3034	46	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	CHEMBL815	3034	46	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	DB12789	3034	46	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
	656511	215988	0	None	-1	7	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	539	6	3	8	-0.2	CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCN(C3=O)S(C)(=O)=O)C3=CC=CC=C3)C(=O)N2[C@H]1C(O)=O	None
	3356	2248	68	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
	4326	2248	68	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
	9867642	2248	68	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
	CHEMBL426559	2248	68	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
	DB11629	2248	68	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
	123619	214644	0	None	125	27	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	358	3	0	4	4.2	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl	None
	5090	214646	0	None	28	31	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	3	0	4	2.6	CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3	None
	1817	2506	60	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	1936	2506	60	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	5282381	2506	60	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	CHEMBL606	2506	60	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	DB00929	2506	60	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
	138	3032	84	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	1882	3032	84	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	5280723	3032	84	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	CHEMBL495	3032	84	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	DB00770	3032	84	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	1883	3033	71	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1916	3033	71	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	5280360	3033	71	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	913	3033	71	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	CHEMBL548	3033	71	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	DB00917	3033	71	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1440	1996	116	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	1909	1996	116	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	3715	1996	116	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	CHEMBL6	1996	116	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	DB00328	1996	116	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
	138	3032	84	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	1882	3032	84	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	5280723	3032	84	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	CHEMBL495	3032	84	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	DB00770	3032	84	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	2720	3793	55	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
	5820	3793	55	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
	6918140	3793	55	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
	CHEMBL1237119	3793	55	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
	DB00374	3793	55	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
	1883	3033	71	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1916	3033	71	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	5280360	3033	71	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	913	3033	71	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	CHEMBL548	3033	71	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	DB00917	3033	71	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	5852	2579	47	None	-288	4	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	17545310
	9931891	2579	47	None	-288	4	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	17545310
	CHEMBL239226	2579	47	None	-288	4	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	17545310
	1895	1976	0	None	-125	16	Rat	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9537820
	6435378	1976	0	None	-125	16	Rat	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9537820
	CHEMBL236025	1976	0	None	-125	16	Rat	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9537820
	DB01088	1976	0	None	-125	16	Rat	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9537820
	1892	736	15	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10462542
	1892	736	15	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10634944
	25886893	736	15	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10462542
	25886893	736	15	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10634944
	CHEMBL1628262	736	15	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10462542
	CHEMBL1628262	736	15	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10634944
	1883	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
	1883	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
	1883	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
	1916	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
	1916	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
	1916	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
	5280360	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
	5280360	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
	5280360	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
	913	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
	913	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
	913	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
	CHEMBL548	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
	CHEMBL548	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
	CHEMBL548	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
	DB00917	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
	DB00917	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
	DB00917	3033	71	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
	1883	3033	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
	1883	3033	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	1883	3033	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	1916	3033	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
	1916	3033	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	1916	3033	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	5280360	3033	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
	5280360	3033	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	5280360	3033	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	913	3033	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
	913	3033	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	913	3033	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	CHEMBL548	3033	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
	CHEMBL548	3033	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	CHEMBL548	3033	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	DB00917	3033	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
	DB00917	3033	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
	DB00917	3033	71	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
	138	3032	84	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	138	3032	84	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	1882	3032	84	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	1882	3032	84	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	5280723	3032	84	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	5280723	3032	84	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	CHEMBL495	3032	84	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	CHEMBL495	3032	84	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	DB00770	3032	84	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	DB00770	3032	84	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	138	3032	84	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
	1882	3032	84	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
	5280723	3032	84	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
	CHEMBL495	3032	84	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
	DB00770	3032	84	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
	1883	3033	71	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	1916	3033	71	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	5280360	3033	71	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	913	3033	71	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	CHEMBL548	3033	71	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	DB00917	3033	71	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
	10110	3038	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	6	2	3	4.3	OC(=O)COc1cccc(c1)NC(=O)c1cc(ccc1F)c1cccc(c1)F	30341781
	59654860	3038	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	6	2	3	4.3	OC(=O)COc1cccc(c1)NC(=O)c1cc(ccc1F)c1cccc(c1)F	30341781
	2720	3793	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
	2720	3793	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
	5820	3793	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
	5820	3793	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
	6918140	3793	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
	6918140	3793	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
	CHEMBL1237119	3793	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
	CHEMBL1237119	3793	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
	DB00374	3793	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
	DB00374	3793	55	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
	10315	2881	20	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	29332128
	44230575	2881	20	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	29332128
	CHEMBL3707245	2881	20	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	29332128
	1932	2897	4	None	-1	6	Mouse	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10746663
	5311228	2897	4	None	-1	6	Mouse	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10746663
	CHEMBL3286796	2897	4	None	-1	6	Mouse	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10746663
	1888	3837	26	None	-501	17	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	10634944
	1974	3837	26	None	-501	17	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	10634944
	5311493	3837	26	None	-501	17	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	10634944
	CHEMBL521784	3837	26	None	-501	17	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	10634944
	1817	2506	60	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
	1936	2506	60	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
	5282381	2506	60	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
	CHEMBL606	2506	60	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
	DB00929	2506	60	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
	1881	3030	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	1891	3030	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	448457	3030	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	CHEMBL1235252	3030	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	DB02056	3030	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	1888	3837	26	None	-316	17	Rat	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	9537820
	1974	3837	26	None	-316	17	Rat	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	9537820
	5311493	3837	26	None	-316	17	Rat	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	9537820
	CHEMBL521784	3837	26	None	-316	17	Rat	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	9537820
	1881	3030	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	1891	3030	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	448457	3030	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	CHEMBL1235252	3030	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	DB02056	3030	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	1931	2901	0	None	-371	2	Mouse	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	14	1	4	4.6	CCCCC[C@@H](/C=C/[C@H]1[C@H](OC)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)OC	10746663
	5311229	2901	0	None	-371	2	Mouse	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	14	1	4	4.6	CCCCC[C@@H](/C=C/[C@H]1[C@H](OC)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)OC	10746663
	1884	3034	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	1884	3034	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
	5280363	3034	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	5280363	3034	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
	912	3034	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	912	3034	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
	CHEMBL815	3034	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	CHEMBL815	3034	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
	DB12789	3034	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
	DB12789	3034	46	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
	1884	3034	46	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	5280363	3034	46	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	912	3034	46	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	CHEMBL815	3034	46	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	DB12789	3034	46	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
	1913	2429	0	None	-15848	15	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	10462542
	1913	2429	0	None	-15848	15	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	10634944
	5311223	2429	0	None	-15848	15	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	10462542
	5311223	2429	0	None	-15848	15	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	10634944
	1895	1976	0	None	-199	16	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	10634944
	6435378	1976	0	None	-199	16	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	10634944
	CHEMBL236025	1976	0	None	-199	16	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	10634944
	DB01088	1976	0	None	-199	16	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	10634944
	1933	2898	0	None	-199	3	Mouse	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	468	14	3	7	2.9	COCc1ccccc1CC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O)O	10746663
	5311230	2898	0	None	-199	3	Mouse	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	468	14	3	7	2.9	COCc1ccccc1CC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O)O	10746663
	1893	783	0	None	-112	13	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	9313928
	5311242	783	0	None	-112	13	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	9313928
	CHEMBL148319	783	0	None	-112	13	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	9313928
	1895	1976	0	None	-158	16	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9313928
	6435378	1976	0	None	-158	16	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9313928
	CHEMBL236025	1976	0	None	-158	16	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9313928
	DB01088	1976	0	None	-158	16	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9313928
	1947	29	0	None	-39	3	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	12	4	5	2.2	O[C@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)CCC[C@H](O)C	8078484
	5283038	29	0	None	-39	3	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	12	4	5	2.2	O[C@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)CCC[C@H](O)C	8078484
	119461	317	66	None	-3	10	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10634944
	1896	317	66	None	-3	10	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10634944
	CHEMBL1317823	317	66	None	-3	10	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10634944
	1917	914	0	None	-22	9	Mouse	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	9313928
	5311044	914	0	None	-22	9	Mouse	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	9313928
	631	914	0	None	-22	9	Mouse	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	9313928
	CHEMBL160629	914	0	None	-22	9	Mouse	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	9313928
	1913	2429	0	None	-8912	15	Rat	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	9537820
	5311223	2429	0	None	-8912	15	Rat	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	9537820
	1928	314	0	None	-12	3	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	10462542
	5310998	314	0	None	-12	3	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	10462542
	1893	783	0	None	-70	13	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	10634944
	5311242	783	0	None	-70	13	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	10634944
	CHEMBL148319	783	0	None	-70	13	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	10634944
	1934	2059	0	None	-63	3	Mouse	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	11	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O	9313928
	5311244	2059	0	None	-63	3	Mouse	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	11	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O	9313928
	CHEMBL4522827	2059	0	None	-63	3	Mouse	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	11	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O	9313928
	1912	27	0	None	-213	6	Rat	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	11	3	4	3.3	OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O	9537820
	5283068	27	0	None	-213	6	Rat	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	11	3	4	3.3	OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O	9537820
	CHEMBL1879970	27	0	None	-213	6	Rat	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	11	3	4	3.3	OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O	9537820
	1930	3281	15	None	-999	3	Mouse	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	13	2	7	2.9	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)OC)O	11917107
	9803828	3281	15	None	-999	3	Mouse	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	13	2	7	2.9	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)OC)O	11917107
	CHEMBL303960	3281	15	None	-999	3	Mouse	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	13	2	7	2.9	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)OC)O	11917107
	DB16315	3281	15	None	-999	3	Mouse	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	13	2	7	2.9	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)OC)O	11917107
	119461	317	66	None	-1	10	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9537820
	1896	317	66	None	-1	10	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9537820
	CHEMBL1317823	317	66	None	-1	10	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9537820
	119461	317	66	None	1	10	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9313928
	1896	317	66	None	1	10	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9313928
	CHEMBL1317823	317	66	None	1	10	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9313928
	1928	314	0	None	-3	3	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	9313928
	5310998	314	0	None	-3	3	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	9313928
	1947	29	0	None	-5	3	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	12	4	5	2.2	O[C@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)CCC[C@H](O)C	9537820
	5283038	29	0	None	-5	3	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	12	4	5	2.2	O[C@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)CCC[C@H](O)C	9537820
	1892	736	15	None	2	9	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	25886893	736	15	None	2	9	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	CHEMBL1628262	736	15	None	2	9	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	1925	7	0	None	-39	6	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	5283055	7	0	None	-39	6	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	CHEMBL3246389	7	0	None	-39	6	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
	1925	7	0	None	-25	6	Rat	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	5283055	7	0	None	-25	6	Rat	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	CHEMBL3246389	7	0	None	-25	6	Rat	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
	1935	2505	0	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	13	3	4	3.9	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)(O)C	10634944
	6436406	2505	0	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	13	3	4	3.9	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)(O)C	10634944
	CHEMBL1201377	2505	0	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	13	3	4	3.9	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)(O)C	10634944
	1926	25	0	None	-8	3	Mouse	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	12	3	4	3.9	CCCCC([C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)(C)C	9313928
	5283066	25	0	None	-8	3	Mouse	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	12	3	4	3.9	CCCCC([C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)(C)C	9313928
	CHEMBL1221529	25	0	None	-8	3	Mouse	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	12	3	4	3.9	CCCCC([C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)(C)C	9313928

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Ligand source activities (1 row/activity)