Ligand source activities (1 row/activity)





Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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DOI

9868867 193901 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 460 12 4 5 3.3 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@@H](O)CCc1cccc(C(F)(F)F)c1 10.1016/j.bmc.2008.11.070
CHEMBL491667 193901 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 460 12 4 5 3.3 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@@H](O)CCc1cccc(C(F)(F)F)c1 10.1016/j.bmc.2008.11.070
1894 7744 41 None 229 5 Human 8.0 pEC50 = 8 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%)
ChEMBL 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10.1016/s0960-894x(00)00273-0
5311053 7744 41 None 229 5 Human 8.0 pEC50 = 8 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%)
ChEMBL 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10.1016/s0960-894x(00)00273-0
CHEMBL37853 7744 41 None 229 5 Human 8.0 pEC50 = 8 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%)
ChEMBL 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10.1016/s0960-894x(00)00273-0
DB11507 7744 41 None 229 5 Human 8.0 pEC50 = 8 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%)
ChEMBL 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10.1016/s0960-894x(00)00273-0
134157766 160829 0 None -1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 390 8 3 5 2.6 O=C(O)CC[C@@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
CHEMBL3984438 160829 0 None -1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 390 8 3 5 2.6 O=C(O)CC[C@@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
134149776 155282 0 None 43 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 390 8 3 5 2.6 O=C(O)CC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
CHEMBL3938300 155282 0 None 43 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 390 8 3 5 2.6 O=C(O)CC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
134151657 159893 0 None 1 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 418 10 3 5 3.4 O=C(O)CCCC[C@@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
CHEMBL3976382 159893 0 None 1 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 418 10 3 5 3.4 O=C(O)CCCC[C@@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
1959 7446 41 None 1737 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 388 11 4 4 3.1 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O 10.1021/acsmedchemlett.6b00415
5283081 7446 41 None 1737 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 388 11 4 4 3.1 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O 10.1021/acsmedchemlett.6b00415
CHEMBL3914661 7446 41 None 1737 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 388 11 4 4 3.1 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O 10.1021/acsmedchemlett.6b00415
1884 9857 52 None -2 9 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPRAgonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmcl.2012.12.058
5280363 9857 52 None -2 9 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPRAgonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmcl.2012.12.058
912 9857 52 None -2 9 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPRAgonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmcl.2012.12.058
CHEMBL815 9857 52 None -2 9 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPRAgonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmcl.2012.12.058
DB12789 9857 52 None -2 9 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPRAgonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmcl.2012.12.058
13174090 158909 9 None -17 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 388 11 3 5 2.8 O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)COc1ccccc1 10.1021/acsmedchemlett.6b00415
CHEMBL3967903 158909 9 None -17 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 388 11 3 5 2.8 O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)COc1ccccc1 10.1021/acsmedchemlett.6b00415
14429703 149150 0 None -5248 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 467 12 4 7 1.5 CS(=O)(=O)NC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)COc1ccccc1 10.1021/acsmedchemlett.6b00415
CHEMBL3889508 149150 0 None -5248 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 467 12 4 7 1.5 CS(=O)(=O)NC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)COc1ccccc1 10.1021/acsmedchemlett.6b00415
44393462 73621 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 458 12 3 5 4.0 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2004.06.037
CHEMBL186192 73621 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 458 12 3 5 4.0 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2004.06.037
44393438 72938 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 424 12 3 5 3.6 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1cccc(Cl)c1 10.1016/j.bmcl.2004.06.037
CHEMBL184264 72938 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 424 12 3 5 3.6 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1cccc(Cl)c1 10.1016/j.bmcl.2004.06.037
71552665 93852 0 None - 1 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPRAgonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR
ChEMBL 450 9 4 8 0.9 NS(=O)(=O)c1ccc(-n2cc([C@H]3[C@H](O)C[C@H](O)[C@@H]3C/C=C\CCCC(=O)O)nn2)cc1 10.1016/j.bmcl.2012.12.058
CHEMBL2326219 93852 0 None - 1 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPRAgonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR
ChEMBL 450 9 4 8 0.9 NS(=O)(=O)c1ccc(-n2cc([C@H]3[C@H](O)C[C@H](O)[C@@H]3C/C=C\CCCC(=O)O)nn2)cc1 10.1016/j.bmcl.2012.12.058
6438324 73465 2 None - 1 Human 8.6 pEC50 = 8.6 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 500 12 3 6 4.4 CC(C)OC(=O)CCC/C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/C(O)COc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2004.06.037
CHEMBL185484 73465 2 None - 1 Human 8.6 pEC50 = 8.6 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 500 12 3 6 4.4 CC(C)OC(=O)CCC/C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/C(O)COc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2004.06.037
68749474 153011 0 None -1 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 390 8 3 5 2.8 O=C(O)CC[C@H]1CCC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1 10.1021/acsmedchemlett.6b00415
CHEMBL3920347 153011 0 None -1 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 390 8 3 5 2.8 O=C(O)CC[C@H]1CCC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1 10.1021/acsmedchemlett.6b00415
44393448 72354 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 424 12 3 5 3.6 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1cccc(Cl)c1 10.1016/j.bmcl.2004.06.037
CHEMBL183193 72354 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 424 12 3 5 3.6 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1cccc(Cl)c1 10.1016/j.bmcl.2004.06.037
44393474 129771 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 340 12 3 4 3.1 CCCCC[C@H](O)/C=C/[C@H]1OC[C@H](O)[C@@H]1C/C=C\CCCC(=O)O 10.1016/j.bmcl.2004.06.037
CHEMBL360869 129771 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 340 12 3 4 3.1 CCCCC[C@H](O)/C=C/[C@H]1OC[C@H](O)[C@@H]1C/C=C\CCCC(=O)O 10.1016/j.bmcl.2004.06.037
1884 9857 52 None -2 9 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmc.2008.11.070
5280363 9857 52 None -2 9 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmc.2008.11.070
912 9857 52 None -2 9 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmc.2008.11.070
CHEMBL815 9857 52 None -2 9 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmc.2008.11.070
DB12789 9857 52 None -2 9 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmc.2008.11.070
1884 9857 52 None -2 9 Human 7.6 pEC50 = 7.6 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmcl.2004.06.037
5280363 9857 52 None -2 9 Human 7.6 pEC50 = 7.6 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmcl.2004.06.037
912 9857 52 None -2 9 Human 7.6 pEC50 = 7.6 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmcl.2004.06.037
CHEMBL815 9857 52 None -2 9 Human 7.6 pEC50 = 7.6 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmcl.2004.06.037
DB12789 9857 52 None -2 9 Human 7.6 pEC50 = 7.6 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmcl.2004.06.037
44393451 175029 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 424 12 3 5 3.6 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1cccc(Cl)c1 10.1016/j.bmcl.2004.06.037
CHEMBL433752 175029 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 424 12 3 5 3.6 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1cccc(Cl)c1 10.1016/j.bmcl.2004.06.037
1883 9856 75 None -162 12 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysisAgonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysis
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
1916 9856 75 None -162 12 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysisAgonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysis
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
5280360 9856 75 None -162 12 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysisAgonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysis
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
913 9856 75 None -162 12 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysisAgonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysis
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
CHEMBL548 9856 75 None -162 12 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysisAgonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysis
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
DB00917 9856 75 None -162 12 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysisAgonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysis
ChEMBL 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10.1021/acsmedchemlett.5b00455
44393422 131183 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 390 12 3 5 3.0 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1ccccc1 10.1016/j.bmcl.2004.06.037
CHEMBL363946 131183 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 390 12 3 5 3.0 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1ccccc1 10.1016/j.bmcl.2004.06.037
56839536 149947 0 None -15 7 Human 6.6 pEC50 = 6.6 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 604 15 2 7 5.1 CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1 nan
CHEMBL3896035 149947 0 None -15 7 Human 6.6 pEC50 = 6.6 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 604 15 2 7 5.1 CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1 nan
56839342 155786 0 None -26 7 Human 6.6 pEC50 = 6.6 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 646 13 2 7 6.0 O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
CHEMBL3942394 155786 0 None -26 7 Human 6.6 pEC50 = 6.6 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 646 13 2 7 6.0 O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
68747479 158900 0 None -7 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 404 9 3 5 3.0 O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
CHEMBL3967855 158900 0 None -7 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 404 9 3 5 3.0 O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
134147356 156391 0 None -123 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 404 9 3 5 3.0 O=C(O)CCC[C@@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
CHEMBL3947086 156391 0 None -123 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 404 9 3 5 3.0 O=C(O)CCC[C@@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
44393601 71634 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 390 12 3 5 3.0 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1ccccc1 10.1016/j.bmcl.2004.06.037
CHEMBL182117 71634 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 390 12 3 5 3.0 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1ccccc1 10.1016/j.bmcl.2004.06.037
44564518 199948 0 None - 1 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 394 12 4 6 1.8 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@@H](O)COc1ccccc1 10.1016/j.bmc.2008.11.070
CHEMBL523143 199948 0 None - 1 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 394 12 4 6 1.8 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@@H](O)COc1ccccc1 10.1016/j.bmc.2008.11.070
1940 8444 41 None 933 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O 10.1021/acsmedchemlett.6b00415
3417 8444 41 None 933 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O 10.1021/acsmedchemlett.6b00415
5311100 8444 41 None 933 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O 10.1021/acsmedchemlett.6b00415
CHEMBL1201379 8444 41 None 933 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O 10.1021/acsmedchemlett.6b00415
DB11519 8444 41 None 933 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O 10.1021/acsmedchemlett.6b00415
68785185 157595 0 None 7 3 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 390 8 3 5 2.8 O=C(O)CC[C@@H]1CCC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1 10.1021/acsmedchemlett.6b00415
CHEMBL3956817 157595 0 None 7 3 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 390 8 3 5 2.8 O=C(O)CC[C@@H]1CCC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1 10.1021/acsmedchemlett.6b00415
1960 9065 42 None - 1 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 390 12 4 4 3.3 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O 10.1016/j.bmc.2008.11.070
6441636 9065 42 None - 1 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 390 12 4 4 3.3 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O 10.1016/j.bmc.2008.11.070
CHEMBL1050 9065 42 None - 1 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 390 12 4 4 3.3 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O 10.1016/j.bmc.2008.11.070
127052613 146984 0 None -39 6 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysisAgonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysis
ChEMBL 431 7 3 7 3.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
CHEMBL3804978 146984 0 None -39 6 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysisAgonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysis
ChEMBL 431 7 3 7 3.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
5282380 131821 41 None - 1 Human 7.5 pEC50 = 7.5 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 432 13 3 5 4.2 CC(C)OC(=O)CCC/C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1 10.1016/j.bmcl.2004.06.037
CHEMBL364375 131821 41 None - 1 Human 7.5 pEC50 = 7.5 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 432 13 3 5 4.2 CC(C)OC(=O)CCC/C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1 10.1016/j.bmcl.2004.06.037
56649302 159445 0 None -9 6 Human 6.5 pEC50 = 6.5 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 630 13 2 7 5.5 O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
CHEMBL3972583 159445 0 None -9 6 Human 6.5 pEC50 = 6.5 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 630 13 2 7 5.5 O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F nan
56839344 158830 0 None -1202 8 Human 6.4 pEC50 = 6.4 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 656 13 2 9 5.1 O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F nan
CHEMBL3967284 158830 0 None -1202 8 Human 6.4 pEC50 = 6.4 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 656 13 2 9 5.1 O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F nan
127052614 147004 0 None -97 6 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysisAgonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysis
ChEMBL 415 7 2 6 4.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
CHEMBL3805176 147004 0 None -97 6 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysisAgonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysis
ChEMBL 415 7 2 6 4.1 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
71552411 93834 0 None - 1 Mouse 5.4 pEC50 = 5.4 Functional
Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPRAgonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR
ChEMBL 516 14 5 9 2.1 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)Nc1nnc(S(N)(=O)=O)s1 10.1016/j.bmcl.2012.12.058
CHEMBL2325977 93834 0 None - 1 Mouse 5.4 pEC50 = 5.4 Functional
Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPRAgonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR
ChEMBL 516 14 5 9 2.1 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)Nc1nnc(S(N)(=O)=O)s1 10.1016/j.bmcl.2012.12.058
6443852 160627 5 None -1 3 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 390 9 3 5 2.8 O=C(O)CCC[C@@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1 10.1021/acsmedchemlett.6b00415
CHEMBL3982726 160627 5 None -1 3 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 390 9 3 5 2.8 O=C(O)CCC[C@@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1 10.1021/acsmedchemlett.6b00415
134138103 154658 0 None 12 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 418 10 3 5 3.4 O=C(O)CCCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
CHEMBL3933326 154658 0 None 12 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 418 10 3 5 3.4 O=C(O)CCCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
56839343 151057 0 None -12 6 Human 6.3 pEC50 = 6.3 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 642 14 2 8 5.4 COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1 nan
CHEMBL3904989 151057 0 None -12 6 Human 6.3 pEC50 = 6.3 Functional
Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.
ChEMBL 642 14 2 8 5.4 COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1 nan
44564468 199486 0 None - 1 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 460 12 4 5 3.3 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@H](O)CCc1cccc(C(F)(F)F)c1 10.1016/j.bmc.2008.11.070
CHEMBL521964 199486 0 None - 1 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 460 12 4 5 3.3 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@H](O)CCc1cccc(C(F)(F)F)c1 10.1016/j.bmc.2008.11.070
5311239 137396 31 None 5 3 Human 5.3 pEC50 = 5.3 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=50%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=50%)
ChEMBL 358 14 4 4 3.5 CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O 10.1016/s0960-894x(00)00273-0
CHEMBL36817 137396 31 None 5 3 Human 5.3 pEC50 = 5.3 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=50%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=50%)
ChEMBL 358 14 4 4 3.5 CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O 10.1016/s0960-894x(00)00273-0
9845493 193884 0 None - 1 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 428 12 4 6 2.4 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@@H](O)COc1cccc(Cl)c1 10.1016/j.bmc.2008.11.070
CHEMBL491474 193884 0 None - 1 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 428 12 4 6 2.4 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@@H](O)COc1cccc(Cl)c1 10.1016/j.bmc.2008.11.070
68747456 152544 0 None 5 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 388 8 3 5 2.6 O=C(O)CCC1=CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
CHEMBL3916674 152544 0 None 5 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 388 8 3 5 2.6 O=C(O)CCC1=CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
44393420 72934 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 390 12 3 5 3.0 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1ccccc1 10.1016/j.bmcl.2004.06.037
CHEMBL184249 72934 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 390 12 3 5 3.0 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1ccccc1 10.1016/j.bmcl.2004.06.037
44393607 104880 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 390 12 3 5 3.0 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1ccccc1 10.1016/j.bmcl.2004.06.037
CHEMBL273444 104880 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 390 12 3 5 3.0 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1ccccc1 10.1016/j.bmcl.2004.06.037
44393436 129762 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 424 12 3 5 3.6 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1cccc(Cl)c1 10.1016/j.bmcl.2004.06.037
CHEMBL360862 129762 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 424 12 3 5 3.6 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1cccc(Cl)c1 10.1016/j.bmcl.2004.06.037
1960 9065 42 None - 1 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPRAgonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR
ChEMBL 390 12 4 4 3.3 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O 10.1016/j.bmcl.2012.12.058
6441636 9065 42 None - 1 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPRAgonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR
ChEMBL 390 12 4 4 3.3 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O 10.1016/j.bmcl.2012.12.058
CHEMBL1050 9065 42 None - 1 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPRAgonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR
ChEMBL 390 12 4 4 3.3 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O 10.1016/j.bmcl.2012.12.058
44564520 193568 0 None - 1 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 428 12 4 6 2.4 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@H](O)COc1cccc(Cl)c1 10.1016/j.bmc.2008.11.070
CHEMBL489109 193568 0 None - 1 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 428 12 4 6 2.4 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@H](O)COc1cccc(Cl)c1 10.1016/j.bmc.2008.11.070
9825293 106831 9 None 83 2 Human 7.2 pEC50 = 7.2 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=87%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=87%)
ChEMBL 456 11 4 4 4.1 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCc1cccc(C(F)(F)F)c1 10.1016/s0960-894x(00)00273-0
CHEMBL287080 106831 9 None 83 2 Human 7.2 pEC50 = 7.2 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=87%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=87%)
ChEMBL 456 11 4 4 4.1 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCc1cccc(C(F)(F)F)c1 10.1016/s0960-894x(00)00273-0
68747472 154562 0 None 7 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 402 9 3 5 3.0 O=C(O)CCCC1=CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
CHEMBL3932636 154562 0 None 7 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 402 9 3 5 3.0 O=C(O)CCCC1=CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
44393431 73481 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 458 12 3 5 4.0 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2004.06.037
CHEMBL185559 73481 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 458 12 3 5 4.0 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2004.06.037
44564519 193885 0 None - 1 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 394 12 4 6 1.8 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@H](O)COc1ccccc1 10.1016/j.bmc.2008.11.070
CHEMBL491475 193885 0 None - 1 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation countingAgonist activity at FP receptor in Swiss mouse 3T3 cells assessed as [3H]-IP accumulation by scintillation counting
ChEMBL 394 12 4 6 1.8 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@H](O)COc1ccccc1 10.1016/j.bmc.2008.11.070
69753740 147000 0 None -1 5 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 390 9 3 5 2.8 O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1 10.1021/acsmedchemlett.6b00415
CHEMBL3805134 147000 0 None -1 5 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 390 9 3 5 2.8 O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1 10.1021/acsmedchemlett.6b00415
68751402 151015 0 None -5 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 416 10 3 5 3.3 O=C(O)CCCCC1=CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
CHEMBL3904644 151015 0 None -5 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 416 10 3 5 3.3 O=C(O)CCCCC1=CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
44393457 130997 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 458 12 3 5 4.0 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2004.06.037
CHEMBL363439 130997 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 458 12 3 5 4.0 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2004.06.037
1884 9857 52 None -2 9 Human 7.1 pEC50 = 7.1 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=75%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=75%)
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/s0960-894x(00)00273-0
5280363 9857 52 None -2 9 Human 7.1 pEC50 = 7.1 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=75%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=75%)
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/s0960-894x(00)00273-0
912 9857 52 None -2 9 Human 7.1 pEC50 = 7.1 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=75%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=75%)
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/s0960-894x(00)00273-0
CHEMBL815 9857 52 None -2 9 Human 7.1 pEC50 = 7.1 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=75%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=75%)
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/s0960-894x(00)00273-0
DB12789 9857 52 None -2 9 Human 7.1 pEC50 = 7.1 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=75%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=75%)
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/s0960-894x(00)00273-0
10389527 160124 19 None 1122 2 Human 7.1 pEC50 = 7.1 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=90%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=90%)
ChEMBL 460 13 4 4 4.6 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1cccc(C(F)(F)F)c1 10.1016/s0960-894x(00)00273-0
CHEMBL39784 160124 19 None 1122 2 Human 7.1 pEC50 = 7.1 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=90%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=90%)
ChEMBL 460 13 4 4 4.6 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1cccc(C(F)(F)F)c1 10.1016/s0960-894x(00)00273-0
126495491 147003 0 None -660 4 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysisAgonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysis
ChEMBL 429 8 2 6 4.5 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCCOc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
CHEMBL3805169 147003 0 None -660 4 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysisAgonist activity at human FP receptor expressed in human Chem1 cells assessed as increase in intracellular calcium level by fluorescence based analysis
ChEMBL 429 8 2 6 4.5 O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCCOc3ccccc3)O2)n1 10.1021/acsmedchemlett.5b00455
134144861 157460 0 None 7 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 430 11 3 5 3.7 O=C(O)CCCCCC1=CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
CHEMBL3955821 157460 0 None 7 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assayAgonist activity at human prostaglandin FP receptor expressed in CHO cells assessed as increase in intracellular calcium level by Fura 2-AM dye based fluorescence assay
ChEMBL 430 11 3 5 3.7 O=C(O)CCCCCC1=CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)OC1 10.1021/acsmedchemlett.6b00415
44393443 73462 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 458 12 3 5 4.0 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2004.06.037
CHEMBL185466 73462 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Efficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cellsEfficacy for stimulation of prostanoid FP receptor-linked phosphoinositide turnover in Swiss 3T3 mouse fibroblast cells
ChEMBL 458 12 3 5 4.0 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2004.06.037
1955 6805 1 None 1258 5 Human 8.1 pEC50 = 8.1 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%)
ChEMBL 428 13 4 5 3.6 O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(00)00273-0
5311240 6805 1 None 1258 5 Human 8.1 pEC50 = 8.1 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%)
ChEMBL 428 13 4 5 3.6 O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(00)00273-0
CHEMBL36041 6805 1 None 1258 5 Human 8.1 pEC50 = 8.1 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%)
ChEMBL 428 13 4 5 3.6 O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(00)00273-0
6441607 161858 28 None -1 4 Human 7.1 pEC50 = 7.1 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=150%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=150%)
ChEMBL 382 12 4 4 3.7 CCCCC(C)(C)[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O 10.1016/s0960-894x(00)00273-0
CHEMBL40183 161858 28 None -1 4 Human 7.1 pEC50 = 7.1 Functional
Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=150%)Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=150%)
ChEMBL 382 12 4 4 3.7 CCCCC(C)(C)[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O 10.1016/s0960-894x(00)00273-0
142451571 187194 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 585 9 2 4 7.0 CCC1CCCN(c2nc3ccc(Br)cc3c(C(=O)NCC(CCC(=O)O)c3ccccc3Cl)c2C)C1 10.1021/acs.jmedchem.0c00834
CHEMBL4752237 187194 0 None - 1 Human 9.3 pIC50 = 9.3 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 585 9 2 4 7.0 CCC1CCCN(c2nc3ccc(Br)cc3c(C(=O)NCC(CCC(=O)O)c3ccccc3Cl)c2C)C1 10.1021/acs.jmedchem.0c00834
135357370 187000 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 593 8 2 4 6.6 Cc1c(N2CCCCC2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1c(F)ccc(F)c1Cl 10.1021/acs.jmedchem.0c00834
CHEMBL4749822 187000 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 593 8 2 4 6.6 Cc1c(N2CCCCC2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1c(F)ccc(F)c1Cl 10.1021/acs.jmedchem.0c00834
142451571 187194 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 585 9 2 4 7.0 CCC1CCCN(c2nc3ccc(Br)cc3c(C(=O)NCC(CCC(=O)O)c3ccccc3Cl)c2C)C1 10.1021/acs.jmedchem.0c00834
CHEMBL4752237 187194 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 585 9 2 4 7.0 CCC1CCCN(c2nc3ccc(Br)cc3c(C(=O)NCC(CCC(=O)O)c3ccccc3Cl)c2C)C1 10.1021/acs.jmedchem.0c00834
142451214 186994 0 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 586 8 2 3 7.3 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1c(F)ccc(F)c1Cl 10.1021/acs.jmedchem.0c00834
CHEMBL4749767 186994 0 None - 1 Human 9.0 pIC50 = 9.0 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 586 8 2 3 7.3 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1c(F)ccc(F)c1Cl 10.1021/acs.jmedchem.0c00834
135357321 187377 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 564 9 2 3 7.4 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(CCCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
CHEMBL4754421 187377 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 564 9 2 3 7.4 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(CCCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
118948515 189305 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 477 4 2 3 5.5 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)Nc1ccc(C(N)=O)cc1F 10.1021/acs.jmedchem.0c00834
CHEMBL4787228 189305 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 477 4 2 3 5.5 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)Nc1ccc(C(N)=O)cc1F 10.1021/acs.jmedchem.0c00834
11283 7373 10 None -1 4 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
146368333 7373 10 None -1 4 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
CHEMBL4643852 7373 10 None -1 4 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
142451571 187194 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 585 9 2 4 7.0 CCC1CCCN(c2nc3ccc(Br)cc3c(C(=O)NCC(CCC(=O)O)c3ccccc3Cl)c2C)C1 10.1021/acs.jmedchem.0c00834
CHEMBL4752237 187194 0 None - 1 Human 8.0 pIC50 = 8.0 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 585 9 2 4 7.0 CCC1CCCN(c2nc3ccc(Br)cc3c(C(=O)NCC(CCC(=O)O)c3ccccc3Cl)c2C)C1 10.1021/acs.jmedchem.0c00834
162658978 188107 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 532 8 2 4 6.0 COc1ccc(C(CNC(=O)c2c(C)c(-c3ccccc3)nc3ccc(Br)cc23)CC(=O)O)cc1 10.1021/acs.jmedchem.0c00834
CHEMBL4762787 188107 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 532 8 2 4 6.0 COc1ccc(C(CNC(=O)c2c(C)c(-c3ccccc3)nc3ccc(Br)cc23)CC(=O)O)cc1 10.1021/acs.jmedchem.0c00834
118948617 186177 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 494 4 2 3 5.3 Cc1c(C(=O)Nc2ccc(C(=O)O)cc2F)c2cc(Br)ccc2[n+]([O-])c1-c1ccccc1 10.1021/acs.jmedchem.0c00834
CHEMBL4739939 186177 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 494 4 2 3 5.3 Cc1c(C(=O)Nc2ccc(C(=O)O)cc2F)c2cc(Br)ccc2[n+]([O-])c1-c1ccccc1 10.1021/acs.jmedchem.0c00834
142451618 186344 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 565 8 2 4 5.8 Cc1c(N2CC(F)(F)C2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
CHEMBL4741813 186344 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 565 8 2 4 5.8 Cc1c(N2CC(F)(F)C2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
135358158 188022 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 532 8 2 4 6.0 COc1ccccc1C(CNC(=O)c1c(C)c(-c2ccccc2)nc2ccc(Br)cc12)CC(=O)O 10.1021/acs.jmedchem.0c00834
CHEMBL4761670 188022 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 532 8 2 4 6.0 COc1ccccc1C(CNC(=O)c1c(C)c(-c2ccccc2)nc2ccc(Br)cc12)CC(=O)O 10.1021/acs.jmedchem.0c00834
CHEMBL1910324 215857 1 None -1 3 Bovine 7.9 pIC50 = 7.9 Functional
Antagonist activity at FP receptor in bovine myometrial strip assessed as inhibition of PGF-2alpha-induced contractionsAntagonist activity at FP receptor in bovine myometrial strip assessed as inhibition of PGF-2alpha-induced contractions
ChEMBL None None None CC[C@@H](C)[C@@H](N)C(=O)N[C@H](CC(C)C)C(=O)NCC(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCCCN)C(=O)O 10.1021/jm200608k
CHEMBL1910324 215857 1 None 1 3 Mouse 7.9 pIC50 = 7.9 Functional
Antagonist activity at FP receptor in mouse myometrial strip assessed as inhibition of PGF-2alpha-induced contractionsAntagonist activity at FP receptor in mouse myometrial strip assessed as inhibition of PGF-2alpha-induced contractions
ChEMBL None None None CC[C@@H](C)[C@@H](N)C(=O)N[C@H](CC(C)C)C(=O)NCC(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCCCN)C(=O)O 10.1021/jm200608k
CHEMBL1910324 215857 1 None -1 3 Sheep 7.9 pIC50 = 7.9 Functional
Antagonist activity at FP receptor in sheep myometrial strip assessed as inhibition of PGF-2alpha-induced contractionsAntagonist activity at FP receptor in sheep myometrial strip assessed as inhibition of PGF-2alpha-induced contractions
ChEMBL None None None CC[C@@H](C)[C@@H](N)C(=O)N[C@H](CC(C)C)C(=O)NCC(=O)N[C@H](Cc1cnc[nH]1)C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCCCN)C(=O)O 10.1021/jm200608k
130405592 189518 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 477 4 2 2 6.7 Cc1c(-c2ccccc2)cc2ccc(Br)cc2c1C(=O)Nc1ccc(C(=O)O)cc1F 10.1021/acs.jmedchem.0c00834
CHEMBL4789967 189518 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 477 4 2 2 6.7 Cc1c(-c2ccccc2)cc2ccc(Br)cc2c1C(=O)Nc1ccc(C(=O)O)cc1F 10.1021/acs.jmedchem.0c00834
130405404 187530 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 456 4 2 3 6.6 Cc1c(-c2ccccc2)nc2ccc(C(C)(C)C)cc2c1C(=O)Nc1ccc(C(=O)O)cc1F 10.1021/acs.jmedchem.0c00834
CHEMBL4756068 187530 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 456 4 2 3 6.6 Cc1c(-c2ccccc2)nc2ccc(C(C)(C)C)cc2c1C(=O)Nc1ccc(C(=O)O)cc1F 10.1021/acs.jmedchem.0c00834
162659434 188027 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 488 6 1 3 6.5 COc1ccccc1C(C)CNC(=O)c1c(C)c(-c2ccccc2)nc2ccc(Br)cc12 10.1021/acs.jmedchem.0c00834
CHEMBL4761725 188027 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 488 6 1 3 6.5 COc1ccccc1C(C)CNC(=O)c1c(C)c(-c2ccccc2)nc2ccc(Br)cc12 10.1021/acs.jmedchem.0c00834
118948371 188215 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 460 4 2 3 5.9 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)Nc1ccc(C(=O)O)cc1 10.1021/acs.jmedchem.0c00834
CHEMBL4764092 188215 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 460 4 2 3 5.9 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)Nc1ccc(C(=O)O)cc1 10.1021/acs.jmedchem.0c00834
162653447 187278 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 459 5 0 3 5.7 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)N(C)CCc1ccccn1 10.1021/acs.jmedchem.0c00834
CHEMBL4753259 187278 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 459 5 0 3 5.7 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)N(C)CCc1ccccn1 10.1021/acs.jmedchem.0c00834
118948324 186636 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 498 4 2 3 6.4 O=C(O)c1ccc(NC(=O)c2c(Cl)c(-c3ccccc3)nc3ccc(Br)cc23)c(F)c1 10.1021/acs.jmedchem.0c00834
CHEMBL4745363 186636 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 498 4 2 3 6.4 O=C(O)c1ccc(NC(=O)c2c(Cl)c(-c3ccccc3)nc3ccc(Br)cc23)c(F)c1 10.1021/acs.jmedchem.0c00834
162671048 189586 0 None 2 2 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 451 5 1 4 5.4 Cc1c(-c2cccs2)nc2ccc(Br)cc2c1C(=O)NCCc1cccnc1 10.1021/acs.jmedchem.0c00834
CHEMBL4790821 189586 0 None 2 2 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 451 5 1 4 5.4 Cc1c(-c2cccs2)nc2ccc(Br)cc2c1C(=O)NCCc1cccnc1 10.1021/acs.jmedchem.0c00834
142451214 186994 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 586 8 2 3 7.3 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1c(F)ccc(F)c1Cl 10.1021/acs.jmedchem.0c00834
CHEMBL4749767 186994 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 586 8 2 3 7.3 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1c(F)ccc(F)c1Cl 10.1021/acs.jmedchem.0c00834
162655188 187496 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 459 5 1 3 5.9 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(C)c1ccccn1 10.1021/acs.jmedchem.0c00834
CHEMBL4755674 187496 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 459 5 1 3 5.9 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(C)c1ccccn1 10.1021/acs.jmedchem.0c00834
135357254 188553 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 532 8 2 4 6.0 COc1cccc(C(CNC(=O)c2c(C)c(-c3ccccc3)nc3ccc(Br)cc23)CC(=O)O)c1 10.1021/acs.jmedchem.0c00834
CHEMBL4777724 188553 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 532 8 2 4 6.0 COc1cccc(C(CNC(=O)c2c(C)c(-c3ccccc3)nc3ccc(Br)cc23)CC(=O)O)c1 10.1021/acs.jmedchem.0c00834
118948280 187133 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 434 4 2 3 6.0 Cc1c(-c2ccccc2)nc2ccc(Cl)cc2c1C(=O)Nc1ccc(C(=O)O)cc1F 10.1021/acs.jmedchem.0c00834
CHEMBL4751462 187133 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 434 4 2 3 6.0 Cc1c(-c2ccccc2)nc2ccc(Cl)cc2c1C(=O)Nc1ccc(C(=O)O)cc1F 10.1021/acs.jmedchem.0c00834
162644141 188619 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 445 5 1 3 5.3 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCCc1ccccn1 10.1021/acs.jmedchem.0c00834
CHEMBL4778430 188619 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 445 5 1 3 5.3 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCCc1ccccn1 10.1021/acs.jmedchem.0c00834
162655888 187531 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 464 5 2 3 6.4 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1CNc1ccc(C(=O)O)cc1F 10.1021/acs.jmedchem.0c00834
CHEMBL4756085 187531 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 464 5 2 3 6.4 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1CNc1ccc(C(=O)O)cc1F 10.1021/acs.jmedchem.0c00834
162659434 188027 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 488 6 1 3 6.5 COc1ccccc1C(C)CNC(=O)c1c(C)c(-c2ccccc2)nc2ccc(Br)cc12 10.1021/acs.jmedchem.0c00834
CHEMBL4761725 188027 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 488 6 1 3 6.5 COc1ccccc1C(C)CNC(=O)c1c(C)c(-c2ccccc2)nc2ccc(Br)cc12 10.1021/acs.jmedchem.0c00834
162671748 189589 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 465 5 1 3 6.4 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1COc1ccc(C(=O)O)cc1F 10.1021/acs.jmedchem.0c00834
CHEMBL4790875 189589 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 465 5 1 3 6.4 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1COc1ccc(C(=O)O)cc1F 10.1021/acs.jmedchem.0c00834
135357370 187000 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 593 8 2 4 6.6 Cc1c(N2CCCCC2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1c(F)ccc(F)c1Cl 10.1021/acs.jmedchem.0c00834
CHEMBL4749822 187000 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 593 8 2 4 6.6 Cc1c(N2CCCCC2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1c(F)ccc(F)c1Cl 10.1021/acs.jmedchem.0c00834
118947820 187517 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 478 4 2 3 6.1 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)Nc1ccc(C(=O)O)cc1F 10.1021/acs.jmedchem.0c00834
CHEMBL4755942 187517 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 478 4 2 3 6.1 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)Nc1ccc(C(=O)O)cc1F 10.1021/acs.jmedchem.0c00834
118948258 187888 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 504 5 2 3 6.6 O=C(O)c1ccc(NC(=O)c2c(C3CC3)c(-c3ccccc3)nc3ccc(Br)cc23)c(F)c1 10.1021/acs.jmedchem.0c00834
CHEMBL4760232 187888 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 504 5 2 3 6.6 O=C(O)c1ccc(NC(=O)c2c(C3CC3)c(-c3ccccc3)nc3ccc(Br)cc23)c(F)c1 10.1021/acs.jmedchem.0c00834
135357195 186426 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 522 6 2 3 6.2 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(C(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
CHEMBL4743035 186426 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 522 6 2 3 6.2 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(C(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
135357378 186552 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 536 7 2 3 6.6 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(CC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
CHEMBL4744552 186552 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 536 7 2 3 6.6 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(CC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
162649924 186892 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 445 5 1 3 5.3 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCCc1cccnc1 10.1021/acs.jmedchem.0c00834
CHEMBL4748513 186892 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 445 5 1 3 5.3 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCCc1cccnc1 10.1021/acs.jmedchem.0c00834
135357378 186552 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 536 7 2 3 6.6 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(CC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
CHEMBL4744552 186552 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 536 7 2 3 6.6 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(CC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
135357195 186426 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 522 6 2 3 6.2 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(C(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
CHEMBL4743035 186426 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 522 6 2 3 6.2 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(C(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
142451544 189145 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 571 8 2 4 6.7 Cc1c(N2CCCCCC2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
CHEMBL4784864 189145 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 571 8 2 4 6.7 Cc1c(N2CCCCCC2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
135357321 187377 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 564 9 2 3 7.4 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(CCCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
CHEMBL4754421 187377 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 564 9 2 3 7.4 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(CCCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
142451565 188705 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 557 8 2 4 6.3 Cc1c(N2CCCCC2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
CHEMBL4779694 188705 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 557 8 2 4 6.3 Cc1c(N2CCCCC2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
130405858 187821 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 494 4 2 4 5.2 Cc1c(C(=O)Nc2ccc(C(=O)O)cc2F)c2cc(Br)ccc2c(=O)n1-c1ccccc1 10.1021/acs.jmedchem.0c00834
CHEMBL4759438 187821 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 494 4 2 4 5.2 Cc1c(C(=O)Nc2ccc(C(=O)O)cc2F)c2cc(Br)ccc2c(=O)n1-c1ccccc1 10.1021/acs.jmedchem.0c00834
142451544 189145 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 571 8 2 4 6.7 Cc1c(N2CCCCCC2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
CHEMBL4784864 189145 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 571 8 2 4 6.7 Cc1c(N2CCCCCC2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
162651877 187028 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 502 4 2 5 5.5 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)Nc1ccc(-c2nnn[nH]2)cc1F 10.1021/acs.jmedchem.0c00834
CHEMBL4750252 187028 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 502 4 2 5 5.5 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)Nc1ccc(-c2nnn[nH]2)cc1F 10.1021/acs.jmedchem.0c00834
142451565 188705 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 557 8 2 4 6.3 Cc1c(N2CCCCC2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
CHEMBL4779694 188705 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 557 8 2 4 6.3 Cc1c(N2CCCCC2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
162664851 188913 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 459 5 1 3 5.7 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NC(C)Cc1ccccn1 10.1021/acs.jmedchem.0c00834
CHEMBL4782206 188913 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 459 5 1 3 5.7 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NC(C)Cc1ccccn1 10.1021/acs.jmedchem.0c00834
130405401 187058 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 526 4 2 3 5.9 Cc1c(-c2ccccc2)nc2ccc(I)cc2c1C(=O)Nc1ccc(C(=O)O)cc1F 10.1021/acs.jmedchem.0c00834
CHEMBL4750703 187058 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 526 4 2 3 5.9 Cc1c(-c2ccccc2)nc2ccc(I)cc2c1C(=O)Nc1ccc(C(=O)O)cc1F 10.1021/acs.jmedchem.0c00834
122551092 189453 1 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 492 4 2 3 5.9 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NC12CCC(C(=O)O)(CC1)CC2 10.1021/acs.jmedchem.0c00834
CHEMBL4789100 189453 1 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 492 4 2 3 5.9 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NC12CCC(C(=O)O)(CC1)CC2 10.1021/acs.jmedchem.0c00834
162651613 187064 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 543 8 2 4 5.9 Cc1c(N2CCCC2)nc2ccc(Br)cc2c1C(=O)NC[C@@H](CCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
CHEMBL4750758 187064 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 543 8 2 4 5.9 Cc1c(N2CCCC2)nc2ccc(Br)cc2c1C(=O)NC[C@@H](CCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
142451571 187194 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 585 9 2 4 7.0 CCC1CCCN(c2nc3ccc(Br)cc3c(C(=O)NCC(CCC(=O)O)c3ccccc3Cl)c2C)C1 10.1021/acs.jmedchem.0c00834
CHEMBL4752237 187194 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 585 9 2 4 7.0 CCC1CCCN(c2nc3ccc(Br)cc3c(C(=O)NCC(CCC(=O)O)c3ccccc3Cl)c2C)C1 10.1021/acs.jmedchem.0c00834
135357792 186449 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 550 8 2 3 7.0 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
CHEMBL4743411 186449 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 550 8 2 3 7.0 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
135357792 186449 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 550 8 2 3 7.0 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
CHEMBL4743411 186449 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 550 8 2 3 7.0 Cc1c(-c2ccccc2)nc2ccc(Br)cc2c1C(=O)NCC(CCC(=O)O)c1ccccc1Cl 10.1021/acs.jmedchem.0c00834
135358158 188022 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 532 8 2 4 6.0 COc1ccccc1C(CNC(=O)c1c(C)c(-c2ccccc2)nc2ccc(Br)cc12)CC(=O)O 10.1021/acs.jmedchem.0c00834
CHEMBL4761670 188022 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 532 8 2 4 6.0 COc1ccccc1C(CNC(=O)c1c(C)c(-c2ccccc2)nc2ccc(Br)cc12)CC(=O)O 10.1021/acs.jmedchem.0c00834
118948479 188940 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 468 4 2 3 6.3 Cc1c(-c2ccccc2)nc2ccc(C(F)(F)F)cc2c1C(=O)Nc1ccc(C(=O)O)cc1F 10.1021/acs.jmedchem.0c00834
CHEMBL4782468 188940 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 468 4 2 3 6.3 Cc1c(-c2ccccc2)nc2ccc(C(F)(F)F)cc2c1C(=O)Nc1ccc(C(=O)O)cc1F 10.1021/acs.jmedchem.0c00834
10402929 64317 0 None - 0 Human 4.4 pKi = 4.4 Functional
Antagonistic activity at Prostanoid FP receptor in human was determinedAntagonistic activity at Prostanoid FP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00056-7
CHEMBL166351 64317 0 None - 0 Human 4.4 pKi = 4.4 Functional
Antagonistic activity at Prostanoid FP receptor in human was determinedAntagonistic activity at Prostanoid FP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00056-7
44377464 126863 0 None - 0 Human 4.2 pKi = 4.2 Functional
Antagonistic activity at Prostanoid FP receptor in human was determinedAntagonistic activity at Prostanoid FP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)cc1Cl 10.1016/s0960-894x(01)00056-7
CHEMBL350832 126863 0 None - 0 Human 4.2 pKi = 4.2 Functional
Antagonistic activity at Prostanoid FP receptor in human was determinedAntagonistic activity at Prostanoid FP receptor in human was determined
ChEMBL 306 4 1 1 4.7 O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)cc1Cl 10.1016/s0960-894x(01)00056-7
9817405 172182 5 None - 0 Human 4.2 pKi = 4.2 Functional
Antagonistic activity at Prostanoid FP receptor in human was determinedAntagonistic activity at Prostanoid FP receptor in human was determined
ChEMBL 288 4 1 1 4.5 O=C(O)/C=C/c1ccccc1Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00056-7
CHEMBL423815 172182 5 None - 0 Human 4.2 pKi = 4.2 Functional
Antagonistic activity at Prostanoid FP receptor in human was determinedAntagonistic activity at Prostanoid FP receptor in human was determined
ChEMBL 288 4 1 1 4.5 O=C(O)/C=C/c1ccccc1Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00056-7
1884 9857 52 None -2 9 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPRAgonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR
Drug Central 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 9857 52 None -2 9 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPRAgonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR
Drug Central 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 9857 52 None -2 9 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPRAgonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR
Drug Central 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 9857 52 None -2 9 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPRAgonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR
Drug Central 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 9857 52 None -2 9 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPRAgonist activity at FP receptor in mouse 3T3 fibroblast cells assessed as intracellular calcium mobilization by FLIPR
Drug Central 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
7452 10508 0 None - 1 Human 9.3 pEC50 = 9.3 Functional
Affinity measured in a cell line stably expressing the recombinant human prostanoid FP receptor.Affinity measured in a cell line stably expressing the recombinant human prostanoid FP receptor.
Guide to Pharmacology 410 11 3 4 3.8 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/C(COc1ccccc1)(F)F)O 15037111
9978917 10508 0 None - 1 Human 9.3 pEC50 = 9.3 Functional
Affinity measured in a cell line stably expressing the recombinant human prostanoid FP receptor.Affinity measured in a cell line stably expressing the recombinant human prostanoid FP receptor.
Guide to Pharmacology 410 11 3 4 3.8 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/C(COc1ccccc1)(F)F)O 15037111
3386 7111 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 410 11 3 5 3.2 OC(=O)CC/C=C\CC[C@@H]1[C@@H](/C=C/[C@H](COc2cccc(c2)Cl)O)OC[C@@H]1O 17076623
59107184 7111 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 410 11 3 5 3.2 OC(=O)CC/C=C\CC[C@@H]1[C@@H](/C=C/[C@H](COc2cccc(c2)Cl)O)OC[C@@H]1O 17076623
1956 7113 0 None -1 2 Mouse 6.7 pEC50 None 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 9 3 3 3.9 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H]([C@@H]1/C=C/[C@@H](C1Cc2c(C1)cccc2)O)F 10454504
1956 7113 0 None 1 2 Rat 6.7 pEC50 None 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 9 3 3 3.9 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H]([C@@H]1/C=C/[C@@H](C1Cc2c(C1)cccc2)O)F 10454504
5311238 7113 0 None -1 2 Mouse 6.7 pEC50 None 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 9 3 3 3.9 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H]([C@@H]1/C=C/[C@@H](C1Cc2c(C1)cccc2)O)F 10454504
5311238 7113 0 None 1 2 Rat 6.7 pEC50 None 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 9 3 3 3.9 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H]([C@@H]1/C=C/[C@@H](C1Cc2c(C1)cccc2)O)F 10454504
CHEMBL1332680 7113 0 None -1 2 Mouse 6.7 pEC50 None 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 9 3 3 3.9 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H]([C@@H]1/C=C/[C@@H](C1Cc2c(C1)cccc2)O)F 10454504
CHEMBL1332680 7113 0 None 1 2 Rat 6.7 pEC50 None 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 402 9 3 3 3.9 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H]([C@@H]1/C=C/[C@@H](C1Cc2c(C1)cccc2)O)F 10454504
1958 7445 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 415 12 4 4 3.1 CCNC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O 12606640
371 7445 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 415 12 4 4 3.1 CCNC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O 12606640
5311027 7445 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 415 12 4 4 3.1 CCNC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O 12606640
CHEMBL1200963 7445 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 415 12 4 4 3.1 CCNC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O 12606640
DB00905 7445 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 415 12 4 4 3.1 CCNC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O 12606640
50902259 9713 1 None -301 2 Human 5.5 pIC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 482 10 2 6 4.2 CC(OC(=O)CCC[C@H]1CC[C@H]2[C@@H](OC1)C[C@H]([C@@H]2/C=C/[C@H](COc1cc(F)ccc1F)O)O)C 25788650
9875 9713 1 None -301 2 Human 5.5 pIC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 482 10 2 6 4.2 CC(OC(=O)CCC[C@H]1CC[C@H]2[C@@H](OC1)C[C@H]([C@@H]2/C=C/[C@H](COc1cc(F)ccc1F)O)O)C 25788650
CHEMBL4297633 9713 1 None -301 2 Human 5.5 pIC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 482 10 2 6 4.2 CC(OC(=O)CCC[C@H]1CC[C@H]2[C@@H](OC1)C[C@H]([C@@H]2/C=C/[C@H](COc1cc(F)ccc1F)O)O)C 25788650
DB12043 9713 1 None -301 2 Human 5.5 pIC50 = 5.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 482 10 2 6 4.2 CC(OC(=O)CCC[C@H]1CC[C@H]2[C@@H](OC1)C[C@H]([C@@H]2/C=C/[C@H](COc1cc(F)ccc1F)O)O)C 25788650
1959 7446 41 None 1737 2 Human 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 11 4 4 3.1 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O 10952685
5283081 7446 41 None 1737 2 Human 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 11 4 4 3.1 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O 10952685
CHEMBL3914661 7446 41 None 1737 2 Human 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 388 11 4 4 3.1 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O 10952685
1955 6805 1 None 1258 5 Human 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 13 4 5 3.6 O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O 10715159
5311240 6805 1 None 1258 5 Human 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 13 4 5 3.6 O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O 10715159
CHEMBL36041 6805 1 None 1258 5 Human 8.8 pIC50 None 8.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology 428 13 4 5 3.6 O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O 10715159




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DOI

68749980 195840 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at FP receptor (unknown origin)Agonist activity at FP receptor (unknown origin)
ChEMBL 440 9 3 5 3.3 O=C(O)CCC[C@H]1CC[C@@H]2[C@@H](/C=C/[C@@H](O)COc3cc(F)ccc3F)[C@H](O)C[C@@H]2OC1 10.1016/j.ejmech.2021.113842
CHEMBL5095395 195840 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at FP receptor (unknown origin)Agonist activity at FP receptor (unknown origin)
ChEMBL 440 9 3 5 3.3 O=C(O)CCC[C@H]1CC[C@@H]2[C@@H](/C=C/[C@@H](O)COc3cc(F)ccc3F)[C@H](O)C[C@@H]2OC1 10.1016/j.ejmech.2021.113842
50902259 9713 1 None - 1 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at FP receptor (unknown origin)Agonist activity at FP receptor (unknown origin)
ChEMBL 482 10 2 6 4.2 CC(OC(=O)CCC[C@H]1CC[C@H]2[C@@H](OC1)C[C@H]([C@@H]2/C=C/[C@H](COc1cc(F)ccc1F)O)O)C 10.1016/j.ejmech.2021.113842
9875 9713 1 None - 1 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at FP receptor (unknown origin)Agonist activity at FP receptor (unknown origin)
ChEMBL 482 10 2 6 4.2 CC(OC(=O)CCC[C@H]1CC[C@H]2[C@@H](OC1)C[C@H]([C@@H]2/C=C/[C@H](COc1cc(F)ccc1F)O)O)C 10.1016/j.ejmech.2021.113842
CHEMBL4297633 9713 1 None - 1 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at FP receptor (unknown origin)Agonist activity at FP receptor (unknown origin)
ChEMBL 482 10 2 6 4.2 CC(OC(=O)CCC[C@H]1CC[C@H]2[C@@H](OC1)C[C@H]([C@@H]2/C=C/[C@H](COc1cc(F)ccc1F)O)O)C 10.1016/j.ejmech.2021.113842
DB12043 9713 1 None - 1 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at FP receptor (unknown origin)Agonist activity at FP receptor (unknown origin)
ChEMBL 482 10 2 6 4.2 CC(OC(=O)CCC[C@H]1CC[C@H]2[C@@H](OC1)C[C@H]([C@@H]2/C=C/[C@H](COc1cc(F)ccc1F)O)O)C 10.1016/j.ejmech.2021.113842
1955 6805 1 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 428 13 4 5 3.6 O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(00)00273-0
5311240 6805 1 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 428 13 4 5 3.6 O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(00)00273-0
CHEMBL36041 6805 1 None - 0 Human 9.0 pIC50 = 9 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 428 13 4 5 3.6 O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O 10.1016/s0960-894x(00)00273-0
1894 7744 41 None 1 5 Human 9.0 pIC50 = 9 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10.1016/s0960-894x(00)00273-0
5311053 7744 41 None 1 5 Human 9.0 pIC50 = 9 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10.1016/s0960-894x(00)00273-0
CHEMBL37853 7744 41 None 1 5 Human 9.0 pIC50 = 9 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10.1016/s0960-894x(00)00273-0
DB11507 7744 41 None 1 5 Human 9.0 pIC50 = 9 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10.1016/s0960-894x(00)00273-0
9825293 106831 9 None - 0 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 456 11 4 4 4.1 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCc1cccc(C(F)(F)F)c1 10.1016/s0960-894x(00)00273-0
CHEMBL287080 106831 9 None - 0 Human 8.0 pIC50 = 8 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 456 11 4 4 4.1 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)CCc1cccc(C(F)(F)F)c1 10.1016/s0960-894x(00)00273-0
44354547 123357 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding at FP human prostaglandin receptor using [3H]- PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]- PGF-2 alpha as radioligand
ChEMBL 390 12 5 4 2.7 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCP(=O)(O)O 10.1021/jm010264b
CHEMBL336543 123357 0 None - 0 Human 6.0 pIC50 = 6 Binding
In vitro binding at FP human prostaglandin receptor using [3H]- PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]- PGF-2 alpha as radioligand
ChEMBL 390 12 5 4 2.7 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCP(=O)(O)O 10.1021/jm010264b
44571206 190768 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Binding affinity to human FP receptor by radioligand binding assayBinding affinity to human FP receptor by radioligand binding assay
ChEMBL 574 6 1 5 6.4 CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)=C1N(Cc1ccc3ccccc3c1)C(=O)C2 10.1016/j.bmcl.2008.12.027
CHEMBL481813 190768 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Binding affinity to human FP receptor by radioligand binding assayBinding affinity to human FP receptor by radioligand binding assay
ChEMBL 574 6 1 5 6.4 CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)=C1N(Cc1ccc3ccccc3c1)C(=O)C2 10.1016/j.bmcl.2008.12.027
10047541 139288 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 416 13 4 6 3.8 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccs1 10.1021/jm990542v
CHEMBL369797 139288 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 416 13 4 6 3.8 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccs1 10.1021/jm990542v
11283 7373 10 None - 1 Rat 8.0 pIC50 = 8.0 Binding
Antagonist activity at rat FPR stably expressed in CHO cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at rat FPR stably expressed in CHO cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
146368333 7373 10 None - 1 Rat 8.0 pIC50 = 8.0 Binding
Antagonist activity at rat FPR stably expressed in CHO cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at rat FPR stably expressed in CHO cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
CHEMBL4643852 7373 10 None - 1 Rat 8.0 pIC50 = 8.0 Binding
Antagonist activity at rat FPR stably expressed in CHO cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assayAntagonist activity at rat FPR stably expressed in CHO cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins followed by PGF2alpha stimulation and measured for 120 secs by fluo-8 AM dye based fluorescence assay
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
44322535 213401 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)
ChEMBL 447 12 5 7 3.2 [N-]=[N+]=Nc1cc(O)cc(OC[C@H](O)/C=C/[C@H]2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O)c1 10.1021/jm00121a046
CHEMBL89096 213401 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)
ChEMBL 447 12 5 7 3.2 [N-]=[N+]=Nc1cc(O)cc(OC[C@H](O)/C=C/[C@H]2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O)c1 10.1021/jm00121a046
102305175 31662 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand
ChEMBL 374 12 4 4 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCC[PH](=O)O 10.1021/jm010264b
CHEMBL134546 31662 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand
ChEMBL 374 12 4 4 3.0 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCC[PH](=O)O 10.1021/jm010264b
15486805 172832 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 394 13 4 5 3.0 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)COc1ccccc1 10.1021/jm990542v
CHEMBL425681 172832 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 394 13 4 5 3.0 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)COc1ccccc1 10.1021/jm990542v
11283 7373 10 None - 1 Mouse 7.9 pIC50 = 7.9 Binding
Antagonist activity at FPR in mouse NIH3T3 cells assessed as inhibition of PGF2alpha-induced cytokine induced neutrophil attracting chemokine production measured after 24 hrs by Bio-Rad assayAntagonist activity at FPR in mouse NIH3T3 cells assessed as inhibition of PGF2alpha-induced cytokine induced neutrophil attracting chemokine production measured after 24 hrs by Bio-Rad assay
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
146368333 7373 10 None - 1 Mouse 7.9 pIC50 = 7.9 Binding
Antagonist activity at FPR in mouse NIH3T3 cells assessed as inhibition of PGF2alpha-induced cytokine induced neutrophil attracting chemokine production measured after 24 hrs by Bio-Rad assayAntagonist activity at FPR in mouse NIH3T3 cells assessed as inhibition of PGF2alpha-induced cytokine induced neutrophil attracting chemokine production measured after 24 hrs by Bio-Rad assay
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
CHEMBL4643852 7373 10 None - 1 Mouse 7.9 pIC50 = 7.9 Binding
Antagonist activity at FPR in mouse NIH3T3 cells assessed as inhibition of PGF2alpha-induced cytokine induced neutrophil attracting chemokine production measured after 24 hrs by Bio-Rad assayAntagonist activity at FPR in mouse NIH3T3 cells assessed as inhibition of PGF2alpha-induced cytokine induced neutrophil attracting chemokine production measured after 24 hrs by Bio-Rad assay
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
1884 9857 52 None -14 22 Bovine 6.9 pIC50 = 6.9 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm00121a046
5280363 9857 52 None -14 22 Bovine 6.9 pIC50 = 6.9 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm00121a046
912 9857 52 None -14 22 Bovine 6.9 pIC50 = 6.9 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm00121a046
CHEMBL815 9857 52 None -14 22 Bovine 6.9 pIC50 = 6.9 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm00121a046
DB12789 9857 52 None -14 22 Bovine 6.9 pIC50 = 6.9 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm00121a046
162671048 189586 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting method
ChEMBL 451 5 1 4 5.4 Cc1c(-c2cccs2)nc2ccc(Br)cc2c1C(=O)NCCc1cccnc1 10.1021/acs.jmedchem.0c00834
CHEMBL4790821 189586 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting method
ChEMBL 451 5 1 4 5.4 Cc1c(-c2cccs2)nc2ccc(Br)cc2c1C(=O)NCCc1cccnc1 10.1021/acs.jmedchem.0c00834
10740699 66847 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 417 13 4 7 3.2 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1nccs1 10.1021/jm990542v
CHEMBL173811 66847 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 417 13 4 7 3.2 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1nccs1 10.1021/jm990542v
6441607 161858 28 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 382 12 4 4 3.7 CCCCC(C)(C)[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O 10.1016/s0960-894x(00)00273-0
CHEMBL40183 161858 28 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 382 12 4 4 3.7 CCCCC(C)(C)[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O 10.1016/s0960-894x(00)00273-0
44285252 127871 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 422 14 4 5 3.6 COc1cccc(CC[C@H](O)CC[C@H]2[C@H](O)C[C@H](O)[C@@H]2CCCCCCC(=O)O)c1 10.1016/s0960-894x(00)00273-0
CHEMBL35715 127871 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 422 14 4 5 3.6 COc1cccc(CC[C@H](O)CC[C@H]2[C@H](O)C[C@H](O)[C@@H]2CCCCCCC(=O)O)c1 10.1016/s0960-894x(00)00273-0
44570666 190049 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Binding affinity to human FP receptor by radioligand binding assayBinding affinity to human FP receptor by radioligand binding assay
ChEMBL 522 6 1 4 4.5 CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3ccc(F)c(F)c3)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2 10.1016/j.bmcl.2008.12.027
CHEMBL479664 190049 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Binding affinity to human FP receptor by radioligand binding assayBinding affinity to human FP receptor by radioligand binding assay
ChEMBL 522 6 1 4 4.5 CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3ccc(F)c(F)c3)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2 10.1016/j.bmcl.2008.12.027
10670992 66830 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 444 13 4 5 4.4 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccc(Cl)c1 10.1021/jm990542v
CHEMBL173680 66830 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 444 13 4 5 4.4 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccc(Cl)c1 10.1021/jm990542v
11283 7373 10 None - 1 Mouse 7.8 pIC50 = 7.8 Binding
Antagonist activity at FPR in mouse NIH3T3 cells assessed as inhibition of PGF2alpha-induced MCP1 production measured after 24 hrs by Bio-Rad assayAntagonist activity at FPR in mouse NIH3T3 cells assessed as inhibition of PGF2alpha-induced MCP1 production measured after 24 hrs by Bio-Rad assay
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
146368333 7373 10 None - 1 Mouse 7.8 pIC50 = 7.8 Binding
Antagonist activity at FPR in mouse NIH3T3 cells assessed as inhibition of PGF2alpha-induced MCP1 production measured after 24 hrs by Bio-Rad assayAntagonist activity at FPR in mouse NIH3T3 cells assessed as inhibition of PGF2alpha-induced MCP1 production measured after 24 hrs by Bio-Rad assay
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
CHEMBL4643852 7373 10 None - 1 Mouse 7.8 pIC50 = 7.8 Binding
Antagonist activity at FPR in mouse NIH3T3 cells assessed as inhibition of PGF2alpha-induced MCP1 production measured after 24 hrs by Bio-Rad assayAntagonist activity at FPR in mouse NIH3T3 cells assessed as inhibition of PGF2alpha-induced MCP1 production measured after 24 hrs by Bio-Rad assay
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
44565193 183639 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of radioligand from FP receptorDisplacement of radioligand from FP receptor
ChEMBL 520 6 1 5 5.6 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(F)c(Cl)c3)cccc21 10.1016/j.bmcl.2008.12.112
CHEMBL461390 183639 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of radioligand from FP receptorDisplacement of radioligand from FP receptor
ChEMBL 520 6 1 5 5.6 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(F)c(Cl)c3)cccc21 10.1016/j.bmcl.2008.12.112
44564804 183479 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of radioligand from FP receptorDisplacement of radioligand from FP receptor
ChEMBL 536 6 1 5 6.1 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)cc3Cl)cccc21 10.1016/j.bmcl.2008.12.112
CHEMBL459885 183479 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of radioligand from FP receptorDisplacement of radioligand from FP receptor
ChEMBL 536 6 1 5 6.1 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)cc3Cl)cccc21 10.1016/j.bmcl.2008.12.112
1894 7744 41 None 1 5 Human 8.7 pIC50 = 8.7 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10.1021/jm990542v
5311053 7744 41 None 1 5 Human 8.7 pIC50 = 8.7 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10.1021/jm990542v
CHEMBL37853 7744 41 None 1 5 Human 8.7 pIC50 = 8.7 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10.1021/jm990542v
DB11507 7744 41 None 1 5 Human 8.7 pIC50 = 8.7 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10.1021/jm990542v
5311234 121917 25 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand
ChEMBL 390 11 4 5 2.5 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)COc1ccccc1 10.1021/jm010264b
CHEMBL334398 121917 25 None - 0 Human 8.7 pIC50 = 8.7 Binding
In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand
ChEMBL 390 11 4 5 2.5 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)COc1ccccc1 10.1021/jm010264b
1884 9857 52 None -4 22 Human 8.6 pIC50 = 8.6 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/s0960-894x(00)00273-0
5280363 9857 52 None -4 22 Human 8.6 pIC50 = 8.6 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/s0960-894x(00)00273-0
912 9857 52 None -4 22 Human 8.6 pIC50 = 8.6 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/s0960-894x(00)00273-0
CHEMBL815 9857 52 None -4 22 Human 8.6 pIC50 = 8.6 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/s0960-894x(00)00273-0
DB12789 9857 52 None -4 22 Human 8.6 pIC50 = 8.6 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/s0960-894x(00)00273-0
1955 6805 1 None - 0 Human 8.6 pIC50 = 8.6 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 428 13 4 5 3.6 O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O 10.1021/jm990542v
5311240 6805 1 None - 0 Human 8.6 pIC50 = 8.6 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 428 13 4 5 3.6 O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O 10.1021/jm990542v
CHEMBL36041 6805 1 None - 0 Human 8.6 pIC50 = 8.6 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 428 13 4 5 3.6 O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O 10.1021/jm990542v
44322596 171679 0 None - 0 Bovine 5.7 pIC50 = 5.7 Binding
Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 430 13 3 5 4.0 COC(=O)CCC/C=C\C[C@@H]1C(/C=C/[C@@H](O)CCCCc2ccccc2)[C@H](O)C[C@@H]1O 10.1021/jm00121a046
CHEMBL422242 171679 0 None - 0 Bovine 5.7 pIC50 = 5.7 Binding
Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 430 13 3 5 4.0 COC(=O)CCC/C=C\C[C@@H]1C(/C=C/[C@@H](O)CCCCc2ccccc2)[C@H](O)C[C@@H]1O 10.1021/jm00121a046
44285208 106688 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 417 13 4 5 3.4 N#Cc1cccc(CC[C@H](O)CC[C@H]2[C@H](O)C[C@H](O)[C@@H]2CCCCCCC(=O)O)c1 10.1016/s0960-894x(00)00273-0
CHEMBL286132 106688 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 417 13 4 5 3.4 N#Cc1cccc(CC[C@H](O)CC[C@H]2[C@H](O)C[C@H](O)[C@@H]2CCCCCCC(=O)O)c1 10.1016/s0960-894x(00)00273-0
44285328 138229 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 410 13 4 4 3.7 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccc(F)cc1 10.1016/s0960-894x(00)00273-0
CHEMBL36911 138229 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 410 13 4 4 3.7 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccc(F)cc1 10.1016/s0960-894x(00)00273-0
44285199 106975 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 460 13 4 4 4.6 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1C(F)(F)F 10.1016/s0960-894x(00)00273-0
CHEMBL288277 106975 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 460 13 4 4 4.6 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1C(F)(F)F 10.1016/s0960-894x(00)00273-0
11283 7373 10 None - 1 Human 7.7 pIC50 = 7.7 Binding
Displacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting method
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
146368333 7373 10 None - 1 Human 7.7 pIC50 = 7.7 Binding
Displacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting method
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
CHEMBL4643852 7373 10 None - 1 Human 7.7 pIC50 = 7.7 Binding
Displacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting method
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
44564990 199429 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of radioligand from FP receptorDisplacement of radioligand from FP receptor
ChEMBL 538 6 1 5 5.7 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(F)c3)cccc21 10.1016/j.bmcl.2008.12.112
CHEMBL521777 199429 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of radioligand from FP receptorDisplacement of radioligand from FP receptor
ChEMBL 538 6 1 5 5.7 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(F)c3)cccc21 10.1016/j.bmcl.2008.12.112
44322613 213270 0 None - 0 Bovine 6.6 pIC50 = 6.6 Binding
Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 416 13 4 4 3.9 O=C(O)CCC/C=C\C[C@@H]1C(/C=C/[C@@H](O)CCCCc2ccccc2)[C@H](O)C[C@@H]1O 10.1021/jm00121a046
CHEMBL88275 213270 0 None - 0 Bovine 6.6 pIC50 = 6.6 Binding
Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 416 13 4 4 3.9 O=C(O)CCC/C=C\C[C@@H]1C(/C=C/[C@@H](O)CCCCc2ccccc2)[C@H](O)C[C@@H]1O 10.1021/jm00121a046
44564571 193594 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of radioligand from FP receptorDisplacement of radioligand from FP receptor
ChEMBL 536 6 1 5 6.1 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21 10.1016/j.bmcl.2008.12.112
CHEMBL489310 193594 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Displacement of radioligand from FP receptorDisplacement of radioligand from FP receptor
ChEMBL 536 6 1 5 6.1 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21 10.1016/j.bmcl.2008.12.112
44190762 183659 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of prostanoid FP receptorInhibition of prostanoid FP receptor
ChEMBL 531 8 1 5 6.6 Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1 10.1016/j.bmcl.2008.07.103
CHEMBL461571 183659 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of prostanoid FP receptorInhibition of prostanoid FP receptor
ChEMBL 531 8 1 5 6.6 Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1 10.1016/j.bmcl.2008.07.103
44571290 190021 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Binding affinity to human FP receptor by radioligand binding assayBinding affinity to human FP receptor by radioligand binding assay
ChEMBL 542 6 1 5 5.4 CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)=C1N(Cc1ccc(F)cc1)C(=O)C2 10.1016/j.bmcl.2008.12.027
CHEMBL479633 190021 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Binding affinity to human FP receptor by radioligand binding assayBinding affinity to human FP receptor by radioligand binding assay
ChEMBL 542 6 1 5 5.4 CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)=C1N(Cc1ccc(F)cc1)C(=O)C2 10.1016/j.bmcl.2008.12.027
10741197 66785 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 428 13 4 5 3.8 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccc(F)c1 10.1021/jm990542v
CHEMBL173499 66785 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 428 13 4 5 3.8 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccc(F)c1 10.1021/jm990542v
44285251 169308 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 422 14 4 5 3.6 COc1ccc(CC[C@H](O)CC[C@H]2[C@H](O)C[C@H](O)[C@@H]2CCCCCCC(=O)O)cc1 10.1016/s0960-894x(00)00273-0
CHEMBL416784 169308 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 422 14 4 5 3.6 COc1ccc(CC[C@H](O)CC[C@H]2[C@H](O)C[C@H](O)[C@@H]2CCCCCCC(=O)O)cc1 10.1016/s0960-894x(00)00273-0
10251023 66735 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 410 13 4 5 3.7 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1ccccc1 10.1021/jm990542v
CHEMBL173299 66735 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 410 13 4 5 3.7 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1ccccc1 10.1021/jm990542v
1884 9857 52 None -4 22 Human 8.5 pIC50 = 8.5 Binding
In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm010264b
5280363 9857 52 None -4 22 Human 8.5 pIC50 = 8.5 Binding
In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm010264b
912 9857 52 None -4 22 Human 8.5 pIC50 = 8.5 Binding
In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm010264b
CHEMBL815 9857 52 None -4 22 Human 8.5 pIC50 = 8.5 Binding
In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm010264b
DB12789 9857 52 None -4 22 Human 8.5 pIC50 = 8.5 Binding
In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm010264b
10981979 123393 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand
ChEMBL 388 12 4 4 3.5 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCP(C)(=O)O 10.1021/jm010264b
CHEMBL336781 123393 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand
ChEMBL 388 12 4 4 3.5 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCP(C)(=O)O 10.1021/jm010264b
44564937 186014 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of radioligand from FP receptorDisplacement of radioligand from FP receptor
ChEMBL 538 6 1 5 5.7 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(F)c(Cl)c3)cccc21 10.1016/j.bmcl.2008.12.112
CHEMBL472754 186014 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of radioligand from FP receptorDisplacement of radioligand from FP receptor
ChEMBL 538 6 1 5 5.7 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(F)c(Cl)c3)cccc21 10.1016/j.bmcl.2008.12.112
44564841 187143 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of radioligand from FP receptorDisplacement of radioligand from FP receptor
ChEMBL 520 6 1 5 5.6 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)cc3F)cccc21 10.1016/j.bmcl.2008.12.112
CHEMBL475152 187143 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of radioligand from FP receptorDisplacement of radioligand from FP receptor
ChEMBL 520 6 1 5 5.6 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)cc3F)cccc21 10.1016/j.bmcl.2008.12.112
44322613 213270 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)
ChEMBL 416 13 4 4 3.9 O=C(O)CCC/C=C\C[C@@H]1C(/C=C/[C@@H](O)CCCCc2ccccc2)[C@H](O)C[C@@H]1O 10.1021/jm00121a046
CHEMBL88275 213270 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)
ChEMBL 416 13 4 4 3.9 O=C(O)CCC/C=C\C[C@@H]1C(/C=C/[C@@H](O)CCCCc2ccccc2)[C@H](O)C[C@@H]1O 10.1021/jm00121a046
10648334 66459 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 478 13 4 5 4.7 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccc(C(F)(F)F)c1 10.1021/jm990542v
CHEMBL172250 66459 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 478 13 4 5 4.7 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccc(C(F)(F)F)c1 10.1021/jm990542v
44322611 213377 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)
ChEMBL 429 12 4 5 4.0 [N-]=[N+]=Nc1ccc(CC[C@H](O)/C=C/[C@H]2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O)cc1 10.1021/jm00121a046
CHEMBL88974 213377 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)
ChEMBL 429 12 4 5 4.0 [N-]=[N+]=Nc1ccc(CC[C@H](O)/C=C/[C@H]2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O)cc1 10.1021/jm00121a046
5311239 137396 31 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 358 14 4 4 3.5 CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O 10.1021/jm990542v
CHEMBL36817 137396 31 None - 0 Human 6.5 pIC50 = 6.5 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 358 14 4 4 3.5 CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O 10.1021/jm990542v
44322291 213601 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)
ChEMBL 555 12 4 5 4.6 [N-]=[N+]=Nc1ccc(CC[C@H](O)/C=C/[C@H]2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O)cc1I 10.1021/jm00121a046
CHEMBL90450 213601 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)
ChEMBL 555 12 4 5 4.6 [N-]=[N+]=Nc1ccc(CC[C@H](O)/C=C/[C@H]2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O)cc1I 10.1021/jm00121a046
44564893 187302 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of radioligand from FP receptorDisplacement of radioligand from FP receptor
ChEMBL 554 6 1 5 6.2 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)cc3Cl)cccc21 10.1016/j.bmcl.2008.12.112
CHEMBL475349 187302 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of radioligand from FP receptorDisplacement of radioligand from FP receptor
ChEMBL 554 6 1 5 6.2 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)cc3Cl)cccc21 10.1016/j.bmcl.2008.12.112
44157014 199396 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of radioligand from FP receptorDisplacement of radioligand from FP receptor
ChEMBL 518 6 1 5 5.9 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21 10.1016/j.bmcl.2008.12.112
CHEMBL521609 199396 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of radioligand from FP receptorDisplacement of radioligand from FP receptor
ChEMBL 518 6 1 5 5.9 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21 10.1016/j.bmcl.2008.12.112
44285161 107135 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 460 13 4 4 4.6 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccc(C(F)(F)F)cc1 10.1016/s0960-894x(00)00273-0
CHEMBL289660 107135 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 460 13 4 4 4.6 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccc(C(F)(F)F)cc1 10.1016/s0960-894x(00)00273-0
25195248 189714 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity to human FP receptor by radioligand binding assayBinding affinity to human FP receptor by radioligand binding assay
ChEMBL 540 6 1 4 4.6 CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(F)c(F)cc3F)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2 10.1016/j.bmcl.2008.12.027
CHEMBL479263 189714 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity to human FP receptor by radioligand binding assayBinding affinity to human FP receptor by radioligand binding assay
ChEMBL 540 6 1 4 4.6 CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(F)c(F)cc3F)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2 10.1016/j.bmcl.2008.12.027
11133176 30961 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand
ChEMBL 402 13 4 4 3.9 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCP(=O)(O)CC 10.1021/jm010264b
CHEMBL133945 30961 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand
ChEMBL 402 13 4 4 3.9 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCP(=O)(O)CC 10.1021/jm010264b
1283333 98310 7 None - 2 Human 5.4 pIC50 = 5.4 Binding
Inhibition of FP receptorInhibition of FP receptor
ChEMBL 456 8 1 3 4.7 CCc1ccccc1N(CC(=O)NCc1ccc(Cl)cc1)S(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2006.12.060
CHEMBL240436 98310 7 None - 2 Human 5.4 pIC50 = 5.4 Binding
Inhibition of FP receptorInhibition of FP receptor
ChEMBL 456 8 1 3 4.7 CCc1ccccc1N(CC(=O)NCc1ccc(Cl)cc1)S(=O)(=O)c1ccc(C)cc1 10.1016/j.bmcl.2006.12.060
10001608 107125 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 410 13 4 4 3.7 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1cccc(F)c1 10.1016/s0960-894x(00)00273-0
CHEMBL289568 107125 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 410 13 4 4 3.7 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1cccc(F)c1 10.1016/s0960-894x(00)00273-0
9888589 175900 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand
ChEMBL 424 11 4 5 3.0 CP(=O)(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)COc1ccccc1 10.1021/jm010264b
CHEMBL440164 175900 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand
ChEMBL 424 11 4 5 3.0 CP(=O)(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)COc1ccccc1 10.1021/jm010264b
44571352 190813 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity to human FP receptor by radioligand binding assayBinding affinity to human FP receptor by radioligand binding assay
ChEMBL 504 6 1 4 4.3 CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(F)cc(F)c3)=C1N(Cc1ccc(F)cc1)C(=O)C2 10.1016/j.bmcl.2008.12.027
CHEMBL482158 190813 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Binding affinity to human FP receptor by radioligand binding assayBinding affinity to human FP receptor by radioligand binding assay
ChEMBL 504 6 1 4 4.3 CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(F)cc(F)c3)=C1N(Cc1ccc(F)cc1)C(=O)C2 10.1016/j.bmcl.2008.12.027
1884 9857 52 None -4 22 Human 7.4 pIC50 = 7.4 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm00121a046
5280363 9857 52 None -4 22 Human 7.4 pIC50 = 7.4 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm00121a046
912 9857 52 None -4 22 Human 7.4 pIC50 = 7.4 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm00121a046
CHEMBL815 9857 52 None -4 22 Human 7.4 pIC50 = 7.4 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm00121a046
DB12789 9857 52 None -4 22 Human 7.4 pIC50 = 7.4 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm00121a046
44285145 107222 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 406 13 4 4 3.9 Cc1ccc(CC[C@H](O)CC[C@H]2[C@H](O)C[C@H](O)[C@@H]2CCCCCCC(=O)O)cc1 10.1016/s0960-894x(00)00273-0
CHEMBL290571 107222 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 406 13 4 4 3.9 Cc1ccc(CC[C@H](O)CC[C@H]2[C@H](O)C[C@H](O)[C@@H]2CCCCCCC(=O)O)cc1 10.1016/s0960-894x(00)00273-0
44564892 187301 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of radioligand from FP receptorDisplacement of radioligand from FP receptor
ChEMBL 554 6 1 5 6.2 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21 10.1016/j.bmcl.2008.12.112
CHEMBL475348 187301 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of radioligand from FP receptorDisplacement of radioligand from FP receptor
ChEMBL 554 6 1 5 6.2 Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21 10.1016/j.bmcl.2008.12.112
71458087 86338 0 None - 0 Bovine 4.3 pIC50 = 4.3 Binding
Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 430 13 3 5 4.0 COC(=O)CCC/C=C\C[C@@H]1C(/C=C/[C@H](O)CCCCc2ccccc2)[C@H](O)C[C@@H]1O 10.1021/jm00121a046
CHEMBL2114229 86338 0 None - 0 Bovine 4.3 pIC50 = 4.3 Binding
Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 430 13 3 5 4.0 COC(=O)CCC/C=C\C[C@@H]1C(/C=C/[C@H](O)CCCCc2ccccc2)[C@H](O)C[C@@H]1O 10.1021/jm00121a046
11283 7373 10 None - 1 Rat 7.3 pIC50 = 7.3 Binding
Antagonist activity at FPR in Wistar rat assessed as inhibition of PGF2alpha-induced uterus contractionAntagonist activity at FPR in Wistar rat assessed as inhibition of PGF2alpha-induced uterus contraction
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
146368333 7373 10 None - 1 Rat 7.3 pIC50 = 7.3 Binding
Antagonist activity at FPR in Wistar rat assessed as inhibition of PGF2alpha-induced uterus contractionAntagonist activity at FPR in Wistar rat assessed as inhibition of PGF2alpha-induced uterus contraction
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
CHEMBL4643852 7373 10 None - 1 Rat 7.3 pIC50 = 7.3 Binding
Antagonist activity at FPR in Wistar rat assessed as inhibition of PGF2alpha-induced uterus contractionAntagonist activity at FPR in Wistar rat assessed as inhibition of PGF2alpha-induced uterus contraction
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
5311239 137396 31 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 358 14 4 4 3.5 CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O 10.1016/s0960-894x(00)00273-0
CHEMBL36817 137396 31 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 358 14 4 4 3.5 CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O 10.1016/s0960-894x(00)00273-0
44285209 138171 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 420 14 4 4 4.1 CCc1cccc(CC[C@H](O)CC[C@H]2[C@H](O)C[C@H](O)[C@@H]2CCCCCCC(=O)O)c1 10.1016/s0960-894x(00)00273-0
CHEMBL36901 138171 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 420 14 4 4 4.1 CCc1cccc(CC[C@H](O)CC[C@H]2[C@H](O)C[C@H](O)[C@@H]2CCCCCCC(=O)O)c1 10.1016/s0960-894x(00)00273-0
15486806 107263 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 392 13 4 4 3.5 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1 10.1021/jm990542v
CHEMBL290969 107263 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 392 13 4 4 3.5 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1 10.1021/jm990542v
44285270 159670 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 422 14 4 5 3.6 COc1ccccc1CC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O 10.1016/s0960-894x(00)00273-0
CHEMBL39746 159670 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 422 14 4 5 3.6 COc1ccccc1CC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O 10.1016/s0960-894x(00)00273-0
46879894 12953 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human FP receptor by radioligand displacement assayBinding affinity to human FP receptor by radioligand displacement assay
ChEMBL 565 6 1 5 7.2 Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(-c3cc(NS(=O)(=O)c4ccc(F)c(F)c4)no3)cc(F)cc12 10.1016/j.bmcl.2009.09.084
CHEMBL1081186 12953 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Binding affinity to human FP receptor by radioligand displacement assayBinding affinity to human FP receptor by radioligand displacement assay
ChEMBL 565 6 1 5 7.2 Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(-c3cc(NS(=O)(=O)c4ccc(F)c(F)c4)no3)cc(F)cc12 10.1016/j.bmcl.2009.09.084
44571291 196935 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity to human FP receptor by radioligand binding assayBinding affinity to human FP receptor by radioligand binding assay
ChEMBL 554 7 1 6 5.3 COc1cccc(CN2C(=O)CC3(C)CCCC(/C=C/C(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)=C23)c1 10.1016/j.bmcl.2008.12.027
CHEMBL517377 196935 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity to human FP receptor by radioligand binding assayBinding affinity to human FP receptor by radioligand binding assay
ChEMBL 554 7 1 6 5.3 COc1cccc(CN2C(=O)CC3(C)CCCC(/C=C/C(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)=C23)c1 10.1016/j.bmcl.2008.12.027
44322588 113813 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)
ChEMBL 445 12 5 6 3.7 [N-]=[N+]=Nc1ccc(CC[C@H](O)/C=C/[C@H]2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O)c(O)c1 10.1021/jm00121a046
CHEMBL315519 113813 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)
ChEMBL 445 12 5 6 3.7 [N-]=[N+]=Nc1ccc(CC[C@H](O)/C=C/[C@H]2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O)c(O)c1 10.1021/jm00121a046
10741017 68062 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 424 13 4 5 4.0 Cc1cccc(SCC(O)CC[C@H]2[C@H](O)C[C@H](O)[C@@H]2CCCCCCC(=O)O)c1 10.1021/jm990542v
CHEMBL176692 68062 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 424 13 4 5 4.0 Cc1cccc(SCC(O)CC[C@H]2[C@H](O)C[C@H](O)[C@@H]2CCCCCCC(=O)O)c1 10.1021/jm990542v
44285146 142011 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 406 13 4 4 3.9 Cc1ccccc1CC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O 10.1016/s0960-894x(00)00273-0
CHEMBL37244 142011 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 406 13 4 4 3.9 Cc1ccccc1CC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O 10.1016/s0960-894x(00)00273-0
44571354 190848 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity to human FP receptor by radioligand binding assayBinding affinity to human FP receptor by radioligand binding assay
ChEMBL 516 7 1 5 4.2 COc1cccc(CN2C(=O)CC3(C)CCCC(/C=C/C(=O)NS(=O)(=O)c4ccc(F)c(F)c4)=C23)c1 10.1016/j.bmcl.2008.12.027
CHEMBL482330 190848 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
Binding affinity to human FP receptor by radioligand binding assayBinding affinity to human FP receptor by radioligand binding assay
ChEMBL 516 7 1 5 4.2 COc1cccc(CN2C(=O)CC3(C)CCCC(/C=C/C(=O)NS(=O)(=O)c4ccc(F)c(F)c4)=C23)c1 10.1016/j.bmcl.2008.12.027
71450954 86339 0 None - 0 Bovine 6.2 pIC50 = 6.2 Binding
Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 416 13 4 4 3.9 O=C(O)CCC/C=C\C[C@@H]1C(/C=C/[C@H](O)CCCCc2ccccc2)[C@H](O)C[C@@H]1O 10.1021/jm00121a046
CHEMBL2114230 86339 0 None - 0 Bovine 6.2 pIC50 = 6.2 Binding
Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 416 13 4 4 3.9 O=C(O)CCC/C=C\C[C@@H]1C(/C=C/[C@H](O)CCCCc2ccccc2)[C@H](O)C[C@@H]1O 10.1021/jm00121a046
11133782 30925 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand
ChEMBL 430 15 4 4 4.6 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCP(=O)(O)CCCC 10.1021/jm010264b
CHEMBL133910 30925 0 None - 0 Human 5.2 pIC50 = 5.2 Binding
In vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligandIn vitro binding at FP human prostaglandin receptor using [3H]PGF-2 alpha as radioligand
ChEMBL 430 15 4 4 4.6 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCP(=O)(O)CCCC 10.1021/jm010264b
71449156 86336 0 None - 0 Bovine 4.2 pIC50 = 4.2 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 555 12 4 5 4.6 [N-]=[N+]=Nc1ccc(CC[C@@H](O)/C=C/[C@H]2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O)cc1I 10.1021/jm00121a046
CHEMBL2114224 86336 0 None - 0 Bovine 4.2 pIC50 = 4.2 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 555 12 4 5 4.6 [N-]=[N+]=Nc1ccc(CC[C@@H](O)/C=C/[C@H]2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O)cc1I 10.1021/jm00121a046
1884 9857 52 None -4 22 Human 8.2 pIC50 = 8.2 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm990542v
5280363 9857 52 None -4 22 Human 8.2 pIC50 = 8.2 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm990542v
912 9857 52 None -4 22 Human 8.2 pIC50 = 8.2 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm990542v
CHEMBL815 9857 52 None -4 22 Human 8.2 pIC50 = 8.2 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm990542v
DB12789 9857 52 None -4 22 Human 8.2 pIC50 = 8.2 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm990542v
44322611 213377 0 None - 0 Bovine 5.2 pIC50 = 5.2 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 429 12 4 5 4.0 [N-]=[N+]=Nc1ccc(CC[C@H](O)/C=C/[C@H]2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O)cc1 10.1021/jm00121a046
CHEMBL88974 213377 0 None - 0 Bovine 5.2 pIC50 = 5.2 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 429 12 4 5 4.0 [N-]=[N+]=Nc1ccc(CC[C@H](O)/C=C/[C@H]2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O)cc1 10.1021/jm00121a046
44322291 213601 0 None - 0 Bovine 5.2 pIC50 = 5.2 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 555 12 4 5 4.6 [N-]=[N+]=Nc1ccc(CC[C@H](O)/C=C/[C@H]2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O)cc1I 10.1021/jm00121a046
CHEMBL90450 213601 0 None - 0 Bovine 5.2 pIC50 = 5.2 Binding
Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)Binding potency towards Prostaglandin F2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in bovine corpora lutea plasma membranes (BCLM)
ChEMBL 555 12 4 5 4.6 [N-]=[N+]=Nc1ccc(CC[C@H](O)/C=C/[C@H]2[C@H](O)C[C@H](O)[C@@H]2C/C=C\CCCC(=O)O)cc1I 10.1021/jm00121a046
71450954 86339 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)
ChEMBL 416 13 4 4 3.9 O=C(O)CCC/C=C\C[C@@H]1C(/C=C/[C@H](O)CCCCc2ccccc2)[C@H](O)C[C@@H]1O 10.1021/jm00121a046
CHEMBL2114230 86339 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)Binding potency towards PGF-2 alpha receptor (competitive binding) with natural [3H]-PGF 2 alpha in ovine luteal cells (OLC)
ChEMBL 416 13 4 4 3.9 O=C(O)CCC/C=C\C[C@@H]1C(/C=C/[C@H](O)CCCCc2ccccc2)[C@H](O)C[C@@H]1O 10.1021/jm00121a046
44570668 190796 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity to human FP receptor by radioligand binding assayBinding affinity to human FP receptor by radioligand binding assay
ChEMBL 572 6 1 4 5.6 CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(F)c(F)cc3F)=C1N(Cc1cccc(Cl)c1Cl)C(=O)C2 10.1016/j.bmcl.2008.12.027
CHEMBL482018 190796 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity to human FP receptor by radioligand binding assayBinding affinity to human FP receptor by radioligand binding assay
ChEMBL 572 6 1 4 5.6 CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(F)c(F)cc3F)=C1N(Cc1cccc(Cl)c1Cl)C(=O)C2 10.1016/j.bmcl.2008.12.027
9909510 107095 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 410 13 4 4 3.7 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1F 10.1016/s0960-894x(00)00273-0
CHEMBL289373 107095 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 410 13 4 4 3.7 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1F 10.1016/s0960-894x(00)00273-0
44570712 189857 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity to human FP receptor by radioligand binding assayBinding affinity to human FP receptor by radioligand binding assay
ChEMBL 572 6 1 4 5.6 CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(F)c(F)cc3F)=C1N(Cc1ccc(Cl)cc1Cl)C(=O)C2 10.1016/j.bmcl.2008.12.027
CHEMBL479439 189857 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Binding affinity to human FP receptor by radioligand binding assayBinding affinity to human FP receptor by radioligand binding assay
ChEMBL 572 6 1 4 5.6 CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(F)c(F)cc3F)=C1N(Cc1ccc(Cl)cc1Cl)C(=O)C2 10.1016/j.bmcl.2008.12.027
10389527 160124 19 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 460 13 4 4 4.6 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1cccc(C(F)(F)F)c1 10.1016/s0960-894x(00)00273-0
CHEMBL39784 160124 19 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 460 13 4 4 4.6 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1cccc(C(F)(F)F)c1 10.1016/s0960-894x(00)00273-0
10389527 160124 19 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 460 13 4 4 4.6 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1cccc(C(F)(F)F)c1 10.1016/s0960-894x(00)00273-0
CHEMBL39784 160124 19 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells
ChEMBL 460 13 4 4 4.6 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1cccc(C(F)(F)F)c1 10.1016/s0960-894x(00)00273-0
15486806 107263 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 392 13 4 4 3.5 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1 10.1016/s0960-894x(00)00273-0
CHEMBL290969 107263 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cellsDisplacement of [3H]PGF-2 from human FP-receptor expressed in CHO-KI cells
ChEMBL 392 13 4 4 3.5 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1 10.1016/s0960-894x(00)00273-0
10739351 175095 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 393 13 5 5 3.0 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CNc1ccccc1 10.1021/jm990542v
CHEMBL434173 175095 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Affinity for human Prostanoid FP receptor expressed in COS-7 cellsAffinity for human Prostanoid FP receptor expressed in COS-7 cells
ChEMBL 393 13 5 5 3.0 O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CNc1ccccc1 10.1021/jm990542v
122522051 159792 14 None - 1 Human 9.0 pKi = 9 Binding
Inhibition Assay: The potency of inhibition of compound I and compound II on prostaglandin F2α receptor was assessed by analyzing the affinity of these compounds for recombinant FP receptor expressed in HEK293-EBNA cells. The results show high binding affinity of compound I and compound II to the human receptor. Selectivity of compound II was tested against all eight prostaglandin receptor subtypes. Selectivity was approximately 10-fold versus prostaglandin E receptor 2 (EP2) and higher than 100-fold against other receptors. Testing the effect of 1 μM compound II against a panel of 50 receptors, channels and enzymes binding sites showed high selectivity for FP. The functional characterization of compound II on human FP was performed in transfected HEK293-EBNA cells.Inhibition Assay: The potency of inhibition of compound I and compound II on prostaglandin F2α receptor was assessed by analyzing the affinity of these compounds for recombinant FP receptor expressed in HEK293-EBNA cells. The results show high binding affinity of compound I and compound II to the human receptor. Selectivity of compound II was tested against all eight prostaglandin receptor subtypes. Selectivity was approximately 10-fold versus prostaglandin E receptor 2 (EP2) and higher than 100-fold against other receptors. Testing the effect of 1 μM compound II against a panel of 50 receptors, channels and enzymes binding sites showed high selectivity for FP. The functional characterization of compound II on human FP was performed in transfected HEK293-EBNA cells.
ChEMBL 599 11 2 7 4.3 CC(C)[C@H](N)C(=O)OCC[C@H](NC(=O)[C@@H]1SCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1)c1ccc(F)cc1 nan
CHEMBL3975522 159792 14 None - 1 Human 9.0 pKi = 9 Binding
Inhibition Assay: The potency of inhibition of compound I and compound II on prostaglandin F2α receptor was assessed by analyzing the affinity of these compounds for recombinant FP receptor expressed in HEK293-EBNA cells. The results show high binding affinity of compound I and compound II to the human receptor. Selectivity of compound II was tested against all eight prostaglandin receptor subtypes. Selectivity was approximately 10-fold versus prostaglandin E receptor 2 (EP2) and higher than 100-fold against other receptors. Testing the effect of 1 μM compound II against a panel of 50 receptors, channels and enzymes binding sites showed high selectivity for FP. The functional characterization of compound II on human FP was performed in transfected HEK293-EBNA cells.Inhibition Assay: The potency of inhibition of compound I and compound II on prostaglandin F2α receptor was assessed by analyzing the affinity of these compounds for recombinant FP receptor expressed in HEK293-EBNA cells. The results show high binding affinity of compound I and compound II to the human receptor. Selectivity of compound II was tested against all eight prostaglandin receptor subtypes. Selectivity was approximately 10-fold versus prostaglandin E receptor 2 (EP2) and higher than 100-fold against other receptors. Testing the effect of 1 μM compound II against a panel of 50 receptors, channels and enzymes binding sites showed high selectivity for FP. The functional characterization of compound II on human FP was performed in transfected HEK293-EBNA cells.
ChEMBL 599 11 2 7 4.3 CC(C)[C@H](N)C(=O)OCC[C@H](NC(=O)[C@@H]1SCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1)c1ccc(F)cc1 nan
1884 9857 52 None -4 22 Human 6.9 pKi = 6.9 Binding
Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteumInhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteum
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm990587w
5280363 9857 52 None -4 22 Human 6.9 pKi = 6.9 Binding
Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteumInhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteum
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm990587w
912 9857 52 None -4 22 Human 6.9 pKi = 6.9 Binding
Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteumInhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteum
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm990587w
CHEMBL815 9857 52 None -4 22 Human 6.9 pKi = 6.9 Binding
Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteumInhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteum
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm990587w
DB12789 9857 52 None -4 22 Human 6.9 pKi = 6.9 Binding
Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteumInhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteum
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1021/jm990587w
44564518 199948 0 None - 1 Bovine 6.9 pKi = 6.9 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 394 12 4 6 1.8 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@@H](O)COc1ccccc1 10.1016/j.bmc.2008.11.070
CHEMBL523143 199948 0 None - 1 Bovine 6.9 pKi = 6.9 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 394 12 4 6 1.8 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@@H](O)COc1ccccc1 10.1016/j.bmc.2008.11.070
53358922 71204 0 None -229 6 Mouse 5.9 pKi = 5.9 Binding
Displacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 522 6 1 6 5.3 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.06.014
CHEMBL1813276 71204 0 None -229 6 Mouse 5.9 pKi = 5.9 Binding
Displacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 522 6 1 6 5.3 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl 10.1016/j.bmc.2011.06.014
1884 9857 52 None -14 22 Bovine 6.9 pKi = 6.9 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmcl.2004.06.037
5280363 9857 52 None -14 22 Bovine 6.9 pKi = 6.9 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmcl.2004.06.037
912 9857 52 None -14 22 Bovine 6.9 pKi = 6.9 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmcl.2004.06.037
CHEMBL815 9857 52 None -14 22 Bovine 6.9 pKi = 6.9 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmcl.2004.06.037
DB12789 9857 52 None -14 22 Bovine 6.9 pKi = 6.9 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmcl.2004.06.037
1884 9857 52 None -14 22 Bovine 6.9 pKi = 6.9 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmc.2008.11.070
5280363 9857 52 None -14 22 Bovine 6.9 pKi = 6.9 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmc.2008.11.070
912 9857 52 None -14 22 Bovine 6.9 pKi = 6.9 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmc.2008.11.070
CHEMBL815 9857 52 None -14 22 Bovine 6.9 pKi = 6.9 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmc.2008.11.070
DB12789 9857 52 None -14 22 Bovine 6.9 pKi = 6.9 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10.1016/j.bmc.2008.11.070
44564468 199486 0 None - 1 Bovine 6.9 pKi = 6.9 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 460 12 4 5 3.3 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@H](O)CCc1cccc(C(F)(F)F)c1 10.1016/j.bmc.2008.11.070
CHEMBL521964 199486 0 None - 1 Bovine 6.9 pKi = 6.9 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 460 12 4 5 3.3 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@H](O)CCc1cccc(C(F)(F)F)c1 10.1016/j.bmc.2008.11.070
9895436 113793 0 None -72 7 Human 5.9 pKi = 5.9 Binding
Compound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 628 8 1 4 7.4 CC(C)(Cc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
CHEMBL315391 113793 0 None -72 7 Human 5.9 pKi = 5.9 Binding
Compound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 628 8 1 4 7.4 CC(C)(Cc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
44564520 193568 0 None - 1 Bovine 6.9 pKi = 6.9 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 428 12 4 6 2.4 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@H](O)COc1cccc(Cl)c1 10.1016/j.bmc.2008.11.070
CHEMBL489109 193568 0 None - 1 Bovine 6.9 pKi = 6.9 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 428 12 4 6 2.4 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@H](O)COc1cccc(Cl)c1 10.1016/j.bmc.2008.11.070
53358921 71215 0 None -295 6 Mouse 5.9 pKi = 5.9 Binding
Displacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 482 7 1 5 5.4 CCN1c2ccccc2C[C@@H]1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1 10.1016/j.bmc.2011.06.014
CHEMBL1813287 71215 0 None -295 6 Mouse 5.9 pKi = 5.9 Binding
Displacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 482 7 1 5 5.4 CCN1c2ccccc2C[C@@H]1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1 10.1016/j.bmc.2011.06.014
11597294 172955 4 None -16982 8 Human 4.9 pKi = 4.9 Binding
Binding affinity to human FP receptor expressed in HEK293 cellsBinding affinity to human FP receptor expressed in HEK293 cells
ChEMBL 435 4 1 2 5.7 O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 10.1021/jm0603668
CHEMBL426387 172955 4 None -16982 8 Human 4.9 pKi = 4.9 Binding
Binding affinity to human FP receptor expressed in HEK293 cellsBinding affinity to human FP receptor expressed in HEK293 cells
ChEMBL 435 4 1 2 5.7 O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21 10.1021/jm0603668
44393448 72354 0 None - 1 Bovine 6.8 pKi = 6.8 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 424 12 3 5 3.6 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1cccc(Cl)c1 10.1016/j.bmcl.2004.06.037
CHEMBL183193 72354 0 None - 1 Bovine 6.8 pKi = 6.8 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 424 12 3 5 3.6 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1cccc(Cl)c1 10.1016/j.bmcl.2004.06.037
11283 7373 10 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting method
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
146368333 7373 10 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting method
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
CHEMBL4643852 7373 10 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting methodDisplacement of [3H]PGF2alpha from full-length recombinant human FP receptor expressed in HEK293 cell membranes measured after 60 mins by scintillation counting method
ChEMBL 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 10.1021/acs.jmedchem.0c00834
10277744 71186 0 None -60 7 Mouse 5.8 pKi = 5.8 Binding
Displacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813116 71186 0 None -60 7 Mouse 5.8 pKi = 5.8 Binding
Displacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
10228100 71188 0 None -295 5 Mouse 5.8 pKi = 5.8 Binding
Displacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813118 71188 0 None -295 5 Mouse 5.8 pKi = 5.8 Binding
Displacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 488 6 1 6 4.7 Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
10181606 213130 0 None -676 7 Human 4.8 pKi = 4.8 Binding
Inhibitory constant against Prostanoid FP receptorInhibitory constant against Prostanoid FP receptor
ChEMBL 437 5 1 4 5.2 O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)00518-8
CHEMBL87371 213130 0 None -676 7 Human 4.8 pKi = 4.8 Binding
Inhibitory constant against Prostanoid FP receptorInhibitory constant against Prostanoid FP receptor
ChEMBL 437 5 1 4 5.2 O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1 10.1016/s0960-894x(02)00518-8
10551015 116889 0 None - 1 Human 5.7 pKi = 5.7 Binding
Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteumInhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteum
ChEMBL 438 11 4 5 3.6 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)CC[C@@H](O)[C@@H]1/C=C/[C@@H](O)COc1cccc(Cl)c1 10.1021/jm990587w
CHEMBL323591 116889 0 None - 1 Human 5.7 pKi = 5.7 Binding
Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteumInhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteum
ChEMBL 438 11 4 5 3.6 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)CC[C@@H](O)[C@@H]1/C=C/[C@@H](O)COc1cccc(Cl)c1 10.1021/jm990587w
15948325 9304 45 None -1621 6 Human 5.7 pKi = 5.7 Binding
Binding affinity to human FP receptor expressed in HEK293 cellsBinding affinity to human FP receptor expressed in HEK293 cells
ChEMBL 603 11 1 8 4.7 CCOc1c2CN(C(=O)c2c(c2c1nccc2)OCC)c1ccc(cc1C)CS(=O)(=O)NC(=O)Cc1ccccc1OC 10.1016/j.bmcl.2008.01.103
5856 9304 45 None -1621 6 Human 5.7 pKi = 5.7 Binding
Binding affinity to human FP receptor expressed in HEK293 cellsBinding affinity to human FP receptor expressed in HEK293 cells
ChEMBL 603 11 1 8 4.7 CCOc1c2CN(C(=O)c2c(c2c1nccc2)OCC)c1ccc(cc1C)CS(=O)(=O)NC(=O)Cc1ccccc1OC 10.1016/j.bmcl.2008.01.103
CHEMBL402162 9304 45 None -1621 6 Human 5.7 pKi = 5.7 Binding
Binding affinity to human FP receptor expressed in HEK293 cellsBinding affinity to human FP receptor expressed in HEK293 cells
ChEMBL 603 11 1 8 4.7 CCOc1c2CN(C(=O)c2c(c2c1nccc2)OCC)c1ccc(cc1C)CS(=O)(=O)NC(=O)Cc1ccccc1OC 10.1016/j.bmcl.2008.01.103
10116116 71185 0 None -269 5 Mouse 5.7 pKi = 5.7 Binding
Displacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813115 71185 0 None -269 5 Mouse 5.7 pKi = 5.7 Binding
Displacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
11476788 168053 0 None -147 6 Human 4.7 pKi = 4.7 Binding
Binding affinity to FP receptorBinding affinity to FP receptor
ChEMBL 463 5 1 5 4.4 CS(=O)(=O)c1cc(F)cc2c1c(C(=O)c1ccc(Cl)cc1)c1n2CCC[C@@H]1CC(=O)O 10.1016/j.bmcl.2008.03.015
CHEMBL412070 168053 0 None -147 6 Human 4.7 pKi = 4.7 Binding
Binding affinity to FP receptorBinding affinity to FP receptor
ChEMBL 463 5 1 5 4.4 CS(=O)(=O)c1cc(F)cc2c1c(C(=O)c1ccc(Cl)cc1)c1n2CCC[C@@H]1CC(=O)O 10.1016/j.bmcl.2008.03.015
10185612 71187 0 None -75 4 Mouse 5.7 pKi = 5.7 Binding
Displacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2cc(Cl)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL1813117 71187 0 None -75 4 Mouse 5.7 pKi = 5.7 Binding
Displacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 504 6 1 6 5.2 Cc1c(CC(=O)O)c2cc(Cl)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
11743212 23936 0 None -7244 7 Human 4.7 pKi = 4.7 Binding
Ability to inhibit the binding of human FP receptor to PGD-2Ability to inhibit the binding of human FP receptor to PGD-2
ChEMBL 426 7 1 3 6.8 O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1 10.1016/s0960-894x(03)00794-7
CHEMBL125588 23936 0 None -7244 7 Human 4.7 pKi = 4.7 Binding
Ability to inhibit the binding of human FP receptor to PGD-2Ability to inhibit the binding of human FP receptor to PGD-2
ChEMBL 426 7 1 3 6.8 O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1 10.1016/s0960-894x(03)00794-7
24765153 191308 0 None -39810 8 Human 4.6 pKi = 4.6 Binding
Binding affinity to FP receptorBinding affinity to FP receptor
ChEMBL 434 5 1 4 6.6 CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@H]1CC(=O)O 10.1016/j.bmcl.2009.03.010
CHEMBL484778 191308 0 None -39810 8 Human 4.6 pKi = 4.6 Binding
Binding affinity to FP receptorBinding affinity to FP receptor
ChEMBL 434 5 1 4 6.6 CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@H]1CC(=O)O 10.1016/j.bmcl.2009.03.010
10299717 71191 0 None -758 6 Mouse 5.6 pKi = 5.6 Binding
Displacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
CHEMBL1813120 71191 0 None -758 6 Mouse 5.6 pKi = 5.6 Binding
Displacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 484 6 1 6 4.9 Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21 10.1016/j.bmc.2011.06.014
44393607 104880 0 None - 1 Bovine 5.6 pKi = 5.6 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 390 12 3 5 3.0 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1ccccc1 10.1016/j.bmcl.2004.06.037
CHEMBL273444 104880 0 None - 1 Bovine 5.6 pKi = 5.6 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 390 12 3 5 3.0 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1ccccc1 10.1016/j.bmcl.2004.06.037
1894 7744 41 None 1 5 Human 7.5 pKi = 7.5 Binding
Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteumInhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteum
ChEMBL 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10.1021/jm990587w
5311053 7744 41 None 1 5 Human 7.5 pKi = 7.5 Binding
Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteumInhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteum
ChEMBL 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10.1021/jm990587w
CHEMBL37853 7744 41 None 1 5 Human 7.5 pKi = 7.5 Binding
Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteumInhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteum
ChEMBL 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10.1021/jm990587w
DB11507 7744 41 None 1 5 Human 7.5 pKi = 7.5 Binding
Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteumInhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteum
ChEMBL 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10.1021/jm990587w
44393462 73621 0 None - 1 Bovine 5.5 pKi = 5.5 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 458 12 3 5 4.0 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2004.06.037
CHEMBL186192 73621 0 None - 1 Bovine 5.5 pKi = 5.5 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 458 12 3 5 4.0 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2004.06.037
10116114 132664 0 None -891 8 Mouse 5.5 pKi = 5.5 Binding
Displacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
CHEMBL364841 132664 0 None -891 8 Mouse 5.5 pKi = 5.5 Binding
Displacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGF2-alpha from mouse FP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.06.014
10116114 132664 0 None -891 8 Mouse 5.5 pKi = 5.5 Binding
Displacement of [3H]PGF2alpha from mouse prostanoid FP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGF2alpha from mouse prostanoid FP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.08.007
CHEMBL364841 132664 0 None -891 8 Mouse 5.5 pKi = 5.5 Binding
Displacement of [3H]PGF2alpha from mouse prostanoid FP receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGF2alpha from mouse prostanoid FP receptor expressed in CHO cells after 60 mins by liquid scintillation counting
ChEMBL 470 6 1 6 4.5 Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1 10.1016/j.bmc.2011.08.007
44393420 72934 0 None - 1 Bovine 6.5 pKi = 6.5 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 390 12 3 5 3.0 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1ccccc1 10.1016/j.bmcl.2004.06.037
CHEMBL184249 72934 0 None - 1 Bovine 6.5 pKi = 6.5 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 390 12 3 5 3.0 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1ccccc1 10.1016/j.bmcl.2004.06.037
15947857 162292 7 None -301 7 Human 6.5 pKi = 6.5 Binding
Binding affinity to human FP receptor expressed in HEK293 cellsBinding affinity to human FP receptor expressed in HEK293 cells
ChEMBL 767 12 1 9 6.3 COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1 10.1016/j.bmcl.2008.01.103
CHEMBL404199 162292 7 None -301 7 Human 6.5 pKi = 6.5 Binding
Binding affinity to human FP receptor expressed in HEK293 cellsBinding affinity to human FP receptor expressed in HEK293 cells
ChEMBL 767 12 1 9 6.3 COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1 10.1016/j.bmcl.2008.01.103
44393431 73481 0 None - 1 Bovine 6.5 pKi = 6.5 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 458 12 3 5 4.0 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2004.06.037
CHEMBL185559 73481 0 None - 1 Bovine 6.5 pKi = 6.5 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 458 12 3 5 4.0 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2004.06.037
9939791 168697 0 None -316 8 Human 5.4 pKi = 5.4 Binding
Compound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 684 8 1 5 7.2 CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F 10.1016/s0960-894x(99)00465-5
CHEMBL415310 168697 0 None -316 8 Human 5.4 pKi = 5.4 Binding
Compound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 684 8 1 5 7.2 CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F 10.1016/s0960-894x(99)00465-5
11488860 26063 0 None -9999 8 Human 5.4 pKi = 5.4 Binding
Binding affinity to prostanoid receptor FP receptorBinding affinity to prostanoid receptor FP receptor
ChEMBL 497 5 1 4 5.7 C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O 10.1016/j.bmcl.2010.10.018
CHEMBL1290413 26063 0 None -9999 8 Human 5.4 pKi = 5.4 Binding
Binding affinity to prostanoid receptor FP receptorBinding affinity to prostanoid receptor FP receptor
ChEMBL 497 5 1 4 5.7 C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O 10.1016/j.bmcl.2010.10.018
9809136 113666 0 None -501 8 Human 5.3 pKi = 5.3 Binding
Compound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 614 7 1 4 7.1 CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
CHEMBL314533 113666 0 None -501 8 Human 5.3 pKi = 5.3 Binding
Compound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 614 7 1 4 7.1 CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
44393422 131183 0 None - 1 Bovine 5.3 pKi = 5.3 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 390 12 3 5 3.0 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1ccccc1 10.1016/j.bmcl.2004.06.037
CHEMBL363946 131183 0 None - 1 Bovine 5.3 pKi = 5.3 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 390 12 3 5 3.0 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1ccccc1 10.1016/j.bmcl.2004.06.037
6438324 73465 2 None - 1 Bovine 7.3 pKi = 7.3 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 500 12 3 6 4.4 CC(C)OC(=O)CCC/C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/C(O)COc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2004.06.037
CHEMBL185484 73465 2 None - 1 Bovine 7.3 pKi = 7.3 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 500 12 3 6 4.4 CC(C)OC(=O)CCC/C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/C(O)COc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2004.06.037
9938626 213612 0 None -331 7 Human 5.3 pKi = 5.3 Binding
Compound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 600 7 1 4 6.9 CC(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
CHEMBL90491 213612 0 None -331 7 Human 5.3 pKi = 5.3 Binding
Compound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 600 7 1 4 6.9 CC(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1 10.1016/s0960-894x(99)00465-5
10717894 173771 0 None - 1 Human 4.3 pKi = 4.3 Binding
Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteumInhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteum
ChEMBL 438 11 4 5 3.6 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)CC[C@@H](O)[C@@H]1/C=C/[C@H](O)COc1cccc(Cl)c1 10.1021/jm990587w
CHEMBL428794 173771 0 None - 1 Human 4.3 pKi = 4.3 Binding
Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteumInhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteum
ChEMBL 438 11 4 5 3.6 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)CC[C@@H](O)[C@@H]1/C=C/[C@H](O)COc1cccc(Cl)c1 10.1021/jm990587w
10217804 157621 0 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibition Assay: The potency of inhibition of compound I and compound II on prostaglandin F2α receptor was assessed by analyzing the affinity of these compounds for recombinant FP receptor expressed in HEK293-EBNA cells. The results show high binding affinity of compound I and compound II to the human receptor. Selectivity of compound II was tested against all eight prostaglandin receptor subtypes. Selectivity was approximately 10-fold versus prostaglandin E receptor 2 (EP2) and higher than 100-fold against other receptors. Testing the effect of 1 μM compound II against a panel of 50 receptors, channels and enzymes binding sites showed high selectivity for FP. The functional characterization of compound II on human FP was performed in transfected HEK293-EBNA cells.Inhibition Assay: The potency of inhibition of compound I and compound II on prostaglandin F2α receptor was assessed by analyzing the affinity of these compounds for recombinant FP receptor expressed in HEK293-EBNA cells. The results show high binding affinity of compound I and compound II to the human receptor. Selectivity of compound II was tested against all eight prostaglandin receptor subtypes. Selectivity was approximately 10-fold versus prostaglandin E receptor 2 (EP2) and higher than 100-fold against other receptors. Testing the effect of 1 μM compound II against a panel of 50 receptors, channels and enzymes binding sites showed high selectivity for FP. The functional characterization of compound II on human FP was performed in transfected HEK293-EBNA cells.
ChEMBL 500 8 2 5 3.8 O=C(N[C@@H](CCO)c1ccc(F)cc1)[C@@H]1SCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1 nan
CHEMBL3957115 157621 0 None - 1 Human 8.2 pKi = 8.2 Binding
Inhibition Assay: The potency of inhibition of compound I and compound II on prostaglandin F2α receptor was assessed by analyzing the affinity of these compounds for recombinant FP receptor expressed in HEK293-EBNA cells. The results show high binding affinity of compound I and compound II to the human receptor. Selectivity of compound II was tested against all eight prostaglandin receptor subtypes. Selectivity was approximately 10-fold versus prostaglandin E receptor 2 (EP2) and higher than 100-fold against other receptors. Testing the effect of 1 μM compound II against a panel of 50 receptors, channels and enzymes binding sites showed high selectivity for FP. The functional characterization of compound II on human FP was performed in transfected HEK293-EBNA cells.Inhibition Assay: The potency of inhibition of compound I and compound II on prostaglandin F2α receptor was assessed by analyzing the affinity of these compounds for recombinant FP receptor expressed in HEK293-EBNA cells. The results show high binding affinity of compound I and compound II to the human receptor. Selectivity of compound II was tested against all eight prostaglandin receptor subtypes. Selectivity was approximately 10-fold versus prostaglandin E receptor 2 (EP2) and higher than 100-fold against other receptors. Testing the effect of 1 μM compound II against a panel of 50 receptors, channels and enzymes binding sites showed high selectivity for FP. The functional characterization of compound II on human FP was performed in transfected HEK293-EBNA cells.
ChEMBL 500 8 2 5 3.8 O=C(N[C@@H](CCO)c1ccc(F)cc1)[C@@H]1SCCN1S(=O)(=O)c1ccc(-c2ccccc2)cc1 nan
9874010 213969 0 None -363 8 Human 5.2 pKi = 5.2 Binding
Compound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 629 8 1 4 6.9 CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
CHEMBL92539 213969 0 None -363 8 Human 5.2 pKi = 5.2 Binding
Compound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assayCompound was evaluated for its secondary binding affinity to human FP receptors by using Aequorin luminescence-based functional calcium assay
ChEMBL 629 8 1 4 6.9 CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1 10.1016/s0960-894x(99)00465-5
44393601 71634 0 None - 1 Bovine 6.2 pKi = 6.2 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 390 12 3 5 3.0 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1ccccc1 10.1016/j.bmcl.2004.06.037
CHEMBL182117 71634 0 None - 1 Bovine 6.2 pKi = 6.2 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 390 12 3 5 3.0 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1ccccc1 10.1016/j.bmcl.2004.06.037
25003075 13610 18 None -22908 7 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]PGF2alpha from human prostanoid FP receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingDisplacement of [3H]PGF2alpha from human prostanoid FP receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
ChEMBL 478 6 2 3 5.8 O=C(O)c1ccc(C2(NC(=O)c3cccc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1 10.1016/j.bmcl.2010.04.065
CHEMBL1084009 13610 18 None -22908 7 Human 5.2 pKi = 5.2 Binding
Displacement of [3H]PGF2alpha from human prostanoid FP receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingDisplacement of [3H]PGF2alpha from human prostanoid FP receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
ChEMBL 478 6 2 3 5.8 O=C(O)c1ccc(C2(NC(=O)c3cccc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1 10.1016/j.bmcl.2010.04.065
44393474 129771 0 None - 1 Bovine 5.2 pKi = 5.2 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 340 12 3 4 3.1 CCCCC[C@H](O)/C=C/[C@H]1OC[C@H](O)[C@@H]1C/C=C\CCCC(=O)O 10.1016/j.bmcl.2004.06.037
CHEMBL360869 129771 0 None - 1 Bovine 5.2 pKi = 5.2 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 340 12 3 4 3.1 CCCCC[C@H](O)/C=C/[C@H]1OC[C@H](O)[C@@H]1C/C=C\CCCC(=O)O 10.1016/j.bmcl.2004.06.037
9845493 193884 0 None - 1 Bovine 6.2 pKi = 6.2 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 428 12 4 6 2.4 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@@H](O)COc1cccc(Cl)c1 10.1016/j.bmc.2008.11.070
CHEMBL491474 193884 0 None - 1 Bovine 6.2 pKi = 6.2 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 428 12 4 6 2.4 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@@H](O)COc1cccc(Cl)c1 10.1016/j.bmc.2008.11.070
9868867 193901 0 None - 1 Bovine 7.1 pKi = 7.1 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 460 12 4 5 3.3 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@@H](O)CCc1cccc(C(F)(F)F)c1 10.1016/j.bmc.2008.11.070
CHEMBL491667 193901 0 None - 1 Bovine 7.1 pKi = 7.1 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 460 12 4 5 3.3 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@@H](O)CCc1cccc(C(F)(F)F)c1 10.1016/j.bmc.2008.11.070
44393438 72938 0 None - 1 Bovine 5.1 pKi = 5.1 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 424 12 3 5 3.6 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1cccc(Cl)c1 10.1016/j.bmcl.2004.06.037
CHEMBL184264 72938 0 None - 1 Bovine 5.1 pKi = 5.1 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 424 12 3 5 3.6 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1cccc(Cl)c1 10.1016/j.bmcl.2004.06.037
44393451 175029 0 None - 1 Bovine 6.1 pKi = 6.1 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 424 12 3 5 3.6 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1cccc(Cl)c1 10.1016/j.bmcl.2004.06.037
CHEMBL433752 175029 0 None - 1 Bovine 6.1 pKi = 6.1 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 424 12 3 5 3.6 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1cccc(Cl)c1 10.1016/j.bmcl.2004.06.037
44564519 193885 0 None - 1 Bovine 7.1 pKi = 7.1 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 394 12 4 6 1.8 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@H](O)COc1ccccc1 10.1016/j.bmc.2008.11.070
CHEMBL491475 193885 0 None - 1 Bovine 7.1 pKi = 7.1 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 394 12 4 6 1.8 O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1OC[C@H](O)COc1ccccc1 10.1016/j.bmc.2008.11.070
44393436 129762 0 None - 1 Bovine 6.1 pKi = 6.1 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 424 12 3 5 3.6 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1cccc(Cl)c1 10.1016/j.bmcl.2004.06.037
CHEMBL360862 129762 0 None - 1 Bovine 6.1 pKi = 6.1 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 424 12 3 5 3.6 O=C(O)CCCC/C=C\C[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@@H](O)COc1cccc(Cl)c1 10.1016/j.bmcl.2004.06.037
5282380 131821 41 None - 1 Bovine 7.0 pKi = 7.0 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 432 13 3 5 4.2 CC(C)OC(=O)CCC/C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1 10.1016/j.bmcl.2004.06.037
CHEMBL364375 131821 41 None - 1 Bovine 7.0 pKi = 7.0 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 432 13 3 5 4.2 CC(C)OC(=O)CCC/C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1 10.1016/j.bmcl.2004.06.037
1960 9065 42 None -38 2 Bovine 7.0 pKi = 7.0 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 390 12 4 4 3.3 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O 10.1016/j.bmc.2008.11.070
6441636 9065 42 None -38 2 Bovine 7.0 pKi = 7.0 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 390 12 4 4 3.3 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O 10.1016/j.bmc.2008.11.070
CHEMBL1050 9065 42 None -38 2 Bovine 7.0 pKi = 7.0 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
ChEMBL 390 12 4 4 3.3 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O 10.1016/j.bmc.2008.11.070
44393457 130997 0 None - 1 Bovine 5.0 pKi = 5 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 458 12 3 5 4.0 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2004.06.037
CHEMBL363439 130997 0 None - 1 Bovine 5.0 pKi = 5 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
ChEMBL 458 12 3 5 4.0 O=C(O)CC/C=C\CCC[C@H]1[C@@H](O)CO[C@@H]1/C=C/[C@H](O)COc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2004.06.037
3356 9060 73 None -398 8 Human 5.0 pKi = 5 Binding
Binding affinity to human FP receptor expressed in HEK293 cellsBinding affinity to human FP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
4326 9060 73 None -398 8 Human 5.0 pKi = 5 Binding
Binding affinity to human FP receptor expressed in HEK293 cellsBinding affinity to human FP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
9867642 9060 73 None -398 8 Human 5.0 pKi = 5 Binding
Binding affinity to human FP receptor expressed in HEK293 cellsBinding affinity to human FP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
CHEMBL426559 9060 73 None -398 8 Human 5.0 pKi = 5 Binding
Binding affinity to human FP receptor expressed in HEK293 cellsBinding affinity to human FP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
DB11629 9060 73 None -398 8 Human 5.0 pKi = 5 Binding
Binding affinity to human FP receptor expressed in HEK293 cellsBinding affinity to human FP receptor expressed in HEK293 cells
ChEMBL 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F 10.1021/jm0603668
11283 7373 10 None - 1 Human 7.7 pIC50 = 7.7 Binding
Receptor binding determined in a proprietary hFP-R binding assay.Receptor binding determined in a proprietary hFP-R binding assay.
Guide to Pharmacology 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 32969660
146368333 7373 10 None - 1 Human 7.7 pIC50 = 7.7 Binding
Receptor binding determined in a proprietary hFP-R binding assay.Receptor binding determined in a proprietary hFP-R binding assay.
Guide to Pharmacology 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 32969660
CHEMBL4643852 7373 10 None - 1 Human 7.7 pIC50 = 7.7 Binding
Receptor binding determined in a proprietary hFP-R binding assay.Receptor binding determined in a proprietary hFP-R binding assay.
Guide to Pharmacology 543 8 2 4 5.9 OC(=O)CC[C@H](c1ccccc1Cl)CNC(=O)c1c(C)c(nc2c1cc(Br)cc2)N1CCCC1 32969660
1884 9857 52 None -4 22 Human 8.1 pKd = 8.1 Binding
GRAC: human FP probeGRAC: human FP probe
Drug Central 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 9857 52 None -4 22 Human 8.1 pKd = 8.1 Binding
GRAC: human FP probeGRAC: human FP probe
Drug Central 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 9857 52 None -4 22 Human 8.1 pKd = 8.1 Binding
GRAC: human FP probeGRAC: human FP probe
Drug Central 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 9857 52 None -4 22 Human 8.1 pKd = 8.1 Binding
GRAC: human FP probeGRAC: human FP probe
Drug Central 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 9857 52 None -4 22 Human 8.1 pKd = 8.1 Binding
GRAC: human FP probeGRAC: human FP probe
Drug Central 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
67861203 222844 0 3H-PGF2Alpha 9 8 Human 9.3 pKi = 9.3 Binding
NoneNone
PDSP KiDatabase 424 11 4 5 3.2 C1C(C(C(C1O)C=CC(COC2=CC(=CC=C2)Cl)O)CC=CCCCC(=O)O)O None
1940 8444 41 3H-PGF2Alpha -41 10 Bovine 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
3417 8444 41 3H-PGF2Alpha -41 10 Bovine 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
5311100 8444 41 3H-PGF2Alpha -41 10 Bovine 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
CHEMBL1201379 8444 41 3H-PGF2Alpha -41 10 Bovine 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
DB11519 8444 41 3H-PGF2Alpha -41 10 Bovine 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
1883 9856 75 3H-PGF2Alpha -41 24 Mouse 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 9856 75 3H-PGF2Alpha -41 24 Mouse 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 9856 75 3H-PGF2Alpha -41 24 Mouse 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 9856 75 3H-PGF2Alpha -41 24 Mouse 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 9856 75 3H-PGF2Alpha -41 24 Mouse 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 9856 75 3H-PGF2Alpha -41 24 Mouse 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
None 222828 0 3H-PGF2Alpha -1 3 Mouse 7.0 pKi = 7 Binding
NoneNone
PDSP KiDatabase 512 11 2 4 4.6 C1CC2C(C(C1O2)CC=CCCCC(=O)O)C=CC(COC3=CC=C(C=C3)I)O None
1888 10672 29 3H-PGF2Alpha -39 17 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
1974 10672 29 3H-PGF2Alpha -39 17 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
5311493 10672 29 3H-PGF2Alpha -39 17 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
CHEMBL521784 10672 29 3H-PGF2Alpha -39 17 Mouse 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
91798918 222842 0 3H-PGF2Alpha -147 10 Bovine 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 400 10 2 6 2.6 COC(=O)CCC=C=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O None
119461 7108 72 3H-PGF2Alpha -30 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 298 3 1 4 3.4 CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C None
1896 7108 72 3H-PGF2Alpha -30 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 298 3 1 4 3.4 CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C None
CHEMBL1317823 7108 72 3H-PGF2Alpha -30 10 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 298 3 1 4 3.4 CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C None
119304 7539 0 3H-PGF2Alpha -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
1878 7539 0 3H-PGF2Alpha -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
40481312 7539 0 3H-PGF2Alpha -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
CHEMBL575504 7539 0 3H-PGF2Alpha -14125 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
122021 7543 0 3H-PGF2Alpha -7585 4 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 459 13 3 5 3.7 OC(=O)CCCCCCC1N(NCC(C2CCCCC2)O)C(=O)N(C1=O)Cc1ccccc1 None
1897 7543 0 3H-PGF2Alpha -7585 4 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 459 13 3 5 3.7 OC(=O)CCCCCCC1N(NCC(C2CCCCC2)O)C(=O)N(C1=O)Cc1ccccc1 None
1899 7543 0 3H-PGF2Alpha -7585 4 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 459 13 3 5 3.7 OC(=O)CCCCCCC1N(NCC(C2CCCCC2)O)C(=O)N(C1=O)Cc1ccccc1 None
1817 9320 68 3H-PGF2Alpha -20 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
1936 9320 68 3H-PGF2Alpha -20 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
5282381 9320 68 3H-PGF2Alpha -20 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
CHEMBL606 9320 68 3H-PGF2Alpha -20 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
DB00929 9320 68 3H-PGF2Alpha -20 12 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
138 9855 88 3H-PGF2Alpha -10000 18 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1882 9855 88 3H-PGF2Alpha -10000 18 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
5280723 9855 88 3H-PGF2Alpha -10000 18 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
CHEMBL495 9855 88 3H-PGF2Alpha -10000 18 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
DB00770 9855 88 3H-PGF2Alpha -10000 18 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 354 13 3 4 3.5 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O None
1980 10434 0 3H-PGF2Alpha -10000 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 387 10 4 4 3.3 O=C(Nc1ccccc1)NNC[C@@H]1[C@@H]2CC[C@H]([C@@H]1C/C=C\CCCC(=O)O)O2 None
1985 10434 0 3H-PGF2Alpha -10000 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 387 10 4 4 3.3 O=C(Nc1ccccc1)NNC[C@@H]1[C@@H]2CC[C@H]([C@@H]1C/C=C\CCCC(=O)O)O2 None
6437074 10434 0 3H-PGF2Alpha -10000 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 387 10 4 4 3.3 O=C(Nc1ccccc1)NNC[C@@H]1[C@@H]2CC[C@H]([C@@H]1C/C=C\CCCC(=O)O)O2 None
5311035 104579 29 3H-PGF2Alpha -91 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 408 13 2 5 4.3 CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 None
CHEMBL271896 104579 29 3H-PGF2Alpha -91 9 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 408 13 2 5 4.3 CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1 None
133126726 222824 0 3H-PGF2Alpha -954 14 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 222824 0 3H-PGF2Alpha -954 14 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
None 222830 0 3H-PGF2Alpha -5248 4 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 587 15 3 8 4.7 C1C(C(C(C1=O)CCC=CCCC(=O)OC2=CC=C(C=C2)NC(=O)C3=CC=CC=C3)OCC(COC4=CC=CC=C4)O)O None
None 222846 0 3H-PGF2Alpha -1 2 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 400 9 3 4 3.4 CC1CCCCC1C(C=CC2C(CC(C2CC=CCOCC(=O)O)Cl)O)O None
None 222849 0 3H-PGF2Alpha 1 2 Bovine 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 150 1 0 4 1.3 C1N(CSCS1)N=O None
132748 223191 0 3H-PGF2Alpha -7 6 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 458 3 2 4 4.6 C1C2=CC=CC=C2OC3=C(N1C(=O)NNC(=O)CCC4=CC=NC=C4)C=C(C=C3)Cl.Cl None
None 223193 0 3H-PGF2Alpha -10 6 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 477 11 1 5 5.1 C1CC(=O)CC1CCC(=CCC(C(=O)O)N2CCOCC2)OCC3=CC=C(C=C3)C4=CC=CC=C4 None
1883 9856 75 3H-PGF2Alpha -57 24 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 9856 75 3H-PGF2Alpha -57 24 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 9856 75 3H-PGF2Alpha -57 24 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 9856 75 3H-PGF2Alpha -57 24 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 9856 75 3H-PGF2Alpha -57 24 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 9856 75 3H-PGF2Alpha -57 24 Human 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1884 9857 52 3H-PGF2Alpha -14 22 Bovine 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 9857 52 3H-PGF2Alpha -14 22 Bovine 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 9857 52 3H-PGF2Alpha -14 22 Bovine 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 9857 52 3H-PGF2Alpha -14 22 Bovine 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 9857 52 3H-PGF2Alpha -14 22 Bovine 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
133126726 222824 0 3H-PGF2Alpha -114 14 Mouse 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 222824 0 3H-PGF2Alpha -114 14 Mouse 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
1913 9242 0 3H-PGF2Alpha -870 15 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 374 12 2 4 4.0 OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O None
5311223 9242 0 3H-PGF2Alpha -870 15 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase 374 12 2 4 4.0 OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O None
1917 7714 0 3H-PGF2Alpha -9 9 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
5311044 7714 0 3H-PGF2Alpha -9 9 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
631 7714 0 3H-PGF2Alpha -9 9 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
CHEMBL160629 7714 0 3H-PGF2Alpha -9 9 Human 5.9 pKi = 5.9 Binding
NoneNone
PDSP KiDatabase 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
None 223192 0 3H-PGF2Alpha -5495 6 Human 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 384 9 3 3 4.3 C1CCC(CC1)C(C=CC2C(CC(C2CC=CCCCC(=O)O)Cl)O)O None
119304 7539 0 3H-PGF2Alpha -2398 9 Mouse 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
1878 7539 0 3H-PGF2Alpha -2398 9 Mouse 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
40481312 7539 0 3H-PGF2Alpha -2398 9 Mouse 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
CHEMBL575504 7539 0 3H-PGF2Alpha -2398 9 Mouse 5.8 pKi = 5.8 Binding
NoneNone
PDSP KiDatabase 368 11 3 4 2.7 OC(=O)CCCCCCC1C(=O)NC(=O)N1CCC(C1CCCCC1)O None
134689669 222829 0 3H-PGF2Alpha -19 12 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase 465 12 3 7 1.7 CS(=O)(=O)NC(=O)CCCC=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O None
1940 8444 41 3H-PGF2Alpha 1 10 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
3417 8444 41 3H-PGF2Alpha 1 10 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
5311100 8444 41 3H-PGF2Alpha 1 10 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
CHEMBL1201379 8444 41 3H-PGF2Alpha 1 10 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
DB11519 8444 41 3H-PGF2Alpha 1 10 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
1551 9066 0 3H-PGF2Alpha -6 7 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
1961 9066 0 3H-PGF2Alpha -6 7 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
5311221 9066 0 3H-PGF2Alpha -6 7 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
CHEMBL1051 9066 0 3H-PGF2Alpha -6 7 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
DB00654 9066 0 3H-PGF2Alpha -6 7 Human 8.6 pKi = 8.6 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
1888 10672 29 3H-PGF2Alpha -9 17 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
1974 10672 29 3H-PGF2Alpha -9 17 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
5311493 10672 29 3H-PGF2Alpha -9 17 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
CHEMBL521784 10672 29 3H-PGF2Alpha -9 17 Human 6.6 pKi = 6.6 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
1881 9853 0 3H-PGF2Alpha -1148 21 Bovine 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1891 9853 0 3H-PGF2Alpha -1148 21 Bovine 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
448457 9853 0 3H-PGF2Alpha -1148 21 Bovine 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL1235252 9853 0 3H-PGF2Alpha -1148 21 Bovine 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB02056 9853 0 3H-PGF2Alpha -1148 21 Bovine 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
134689669 222829 0 3H-PGF2Alpha -1380 12 Bovine 5.6 pKi = 5.6 Binding
NoneNone
PDSP KiDatabase 465 12 3 7 1.7 CS(=O)(=O)NC(=O)CCCC=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O None
1884 9857 52 3H-PGF2Alpha -4 22 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 9857 52 3H-PGF2Alpha -4 22 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 9857 52 3H-PGF2Alpha -4 22 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 9857 52 3H-PGF2Alpha -4 22 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 9857 52 3H-PGF2Alpha -4 22 Human 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1884 9857 52 3H-PGF2Alpha 4 22 Mouse 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 9857 52 3H-PGF2Alpha 4 22 Mouse 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 9857 52 3H-PGF2Alpha 4 22 Mouse 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 9857 52 3H-PGF2Alpha 4 22 Mouse 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 9857 52 3H-PGF2Alpha 4 22 Mouse 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1940 8444 41 3H-PGF2Alpha -1 10 Mouse 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
3417 8444 41 3H-PGF2Alpha -1 10 Mouse 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
5311100 8444 41 3H-PGF2Alpha -1 10 Mouse 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
CHEMBL1201379 8444 41 3H-PGF2Alpha -1 10 Mouse 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
DB11519 8444 41 3H-PGF2Alpha -1 10 Mouse 8.4 pKi = 8.4 Binding
NoneNone
PDSP KiDatabase 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O None
67861203 222844 0 3H-PGF2Alpha -66 8 Bovine 7.5 pKi = 7.5 Binding
NoneNone
PDSP KiDatabase 424 11 4 5 3.2 C1C(C(C(C1O)C=CC(COC2=CC(=CC=C2)Cl)O)CC=CCCCC(=O)O)O None
1883 9856 75 3H-PGF2Alpha -3388 24 Bovine 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 9856 75 3H-PGF2Alpha -3388 24 Bovine 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 9856 75 3H-PGF2Alpha -3388 24 Bovine 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 9856 75 3H-PGF2Alpha -3388 24 Bovine 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 9856 75 3H-PGF2Alpha -3388 24 Bovine 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 9856 75 3H-PGF2Alpha -3388 24 Bovine 5.5 pKi = 5.5 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
None 222850 0 3H-PGF2Alpha 2 2 Bovine 5.4 pKi = 5.4 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 CC(C)OC(=O)CCCC=CCC1C(CC(C1CCC(CCC2=CC=CC=C2)O)O)O None
133126726 222824 0 3H-PGF2Alpha -40 14 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
24868263 222824 0 3H-PGF2Alpha -40 14 Human 6.4 pKi = 6.4 Binding
NoneNone
PDSP KiDatabase 350 10 3 3 4.1 CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
1881 9853 0 3H-PGF2Alpha -22 21 Mouse 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1891 9853 0 3H-PGF2Alpha -22 21 Mouse 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
448457 9853 0 3H-PGF2Alpha -22 21 Mouse 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL1235252 9853 0 3H-PGF2Alpha -22 21 Mouse 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB02056 9853 0 3H-PGF2Alpha -22 21 Mouse 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1884 9857 52 3H-PGF2Alpha -4 22 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 9857 52 3H-PGF2Alpha -4 22 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 9857 52 3H-PGF2Alpha -4 22 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 9857 52 3H-PGF2Alpha -4 22 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 9857 52 3H-PGF2Alpha -4 22 Human 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
3356 9060 73 None -398 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human FP receptor expressed in HEK293 cellsBinding affinity to human FP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
4326 9060 73 None -398 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human FP receptor expressed in HEK293 cellsBinding affinity to human FP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
9867642 9060 73 None -398 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human FP receptor expressed in HEK293 cellsBinding affinity to human FP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
CHEMBL426559 9060 73 None -398 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human FP receptor expressed in HEK293 cellsBinding affinity to human FP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
DB11629 9060 73 None -398 8 Human 8.3 pKi = 8.3 Binding
Binding affinity to human FP receptor expressed in HEK293 cellsBinding affinity to human FP receptor expressed in HEK293 cells
Drug Central 435 5 1 4 4.4 OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F None
1958 7445 0 None - 1 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 415 12 4 4 3.1 CCNC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O None
371 7445 0 None - 1 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 415 12 4 4 3.1 CCNC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O None
5311027 7445 0 None - 1 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 415 12 4 4 3.1 CCNC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O None
CHEMBL1200963 7445 0 None - 1 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 415 12 4 4 3.1 CCNC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O None
DB00905 7445 0 None - 1 Human 8.3 pKi = 8.3 Binding
NoneNone
Drug Central 415 12 4 4 3.1 CCNC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O None
1913 9242 0 3H-PGF2Alpha -3630 15 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 374 12 2 4 4.0 OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O None
5311223 9242 0 3H-PGF2Alpha -3630 15 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 374 12 2 4 4.0 OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O None
1551 9066 0 3H-PGF2Alpha -6 7 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
1961 9066 0 3H-PGF2Alpha -6 7 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
5311221 9066 0 3H-PGF2Alpha -6 7 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
CHEMBL1051 9066 0 3H-PGF2Alpha -6 7 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
DB00654 9066 0 3H-PGF2Alpha -6 7 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
134689669 222829 0 3H-PGF2Alpha -316 12 Mouse 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 465 12 3 7 1.7 CS(=O)(=O)NC(=O)CCCC=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O None
None 222847 0 3H-PGF2Alpha 1 2 Bovine 5.2 pKi = 5.2 Binding
NoneNone
PDSP KiDatabase 424 16 2 5 5.1 CCCCCCCC(=O)CCC1C(CC(C1CC=CCCCC(=O)OC(C)C)O)O None
138107701 194243 46 None -6 15 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
5311181 194243 46 None -6 15 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
CHEMBL494 194243 46 None -6 15 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 360 8 3 3 3.5 CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O None
1551 9066 0 None -6 7 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
1961 9066 0 None -6 7 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
5311221 9066 0 None -6 7 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
CHEMBL1051 9066 0 None -6 7 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
DB00654 9066 0 None -6 7 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
134689669 222829 0 None -19 12 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 465 12 3 7 1.7 CS(=O)(=O)NC(=O)CCCC=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O None
1881 9853 0 3H-PGF2Alpha -5 21 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1891 9853 0 3H-PGF2Alpha -5 21 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
448457 9853 0 3H-PGF2Alpha -5 21 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL1235252 9853 0 3H-PGF2Alpha -5 21 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB02056 9853 0 3H-PGF2Alpha -5 21 Human 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1884 9857 52 None -14 22 Bovine 8.2 pKi = 8.2 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
Drug Central 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
5280363 9857 52 None -14 22 Bovine 8.2 pKi = 8.2 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
Drug Central 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
912 9857 52 None -14 22 Bovine 8.2 pKi = 8.2 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
Drug Central 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
CHEMBL815 9857 52 None -14 22 Bovine 8.2 pKi = 8.2 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
Drug Central 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
DB12789 9857 52 None -14 22 Bovine 8.2 pKi = 8.2 Binding
Binding affinity for Prostanoid FP receptor of bovine corpus luteumBinding affinity for Prostanoid FP receptor of bovine corpus luteum
Drug Central 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O None
1883 9856 75 None -57 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 9856 75 None -57 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 9856 75 None -57 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 9856 75 None -57 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 9856 75 None -57 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 9856 75 None -57 24 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
89077401 222823 0 3H-PGF2Alpha -56 12 Human 6.2 pKi = 6.2 Binding
NoneNone
PDSP KiDatabase 360 8 3 3 3.5 CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O None
1883 9856 75 None -41 24 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
1916 9856 75 None -41 24 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
5280360 9856 75 None -41 24 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
913 9856 75 None -41 24 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
CHEMBL548 9856 75 None -41 24 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
DB00917 9856 75 None -41 24 Mouse 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O None
11156438 9064 0 None -1 2 Bovine 8.2 pKi = 8.2 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
Drug Central 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O None
5261 9064 0 None -1 2 Bovine 8.2 pKi = 8.2 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
Drug Central 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O None
9635 9064 0 None -1 2 Bovine 8.2 pKi = 8.2 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
Drug Central 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O None
CHEMBL2364612 9064 0 None -1 2 Bovine 8.2 pKi = 8.2 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
Drug Central 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O None
DB11660 9064 0 None -1 2 Bovine 8.2 pKi = 8.2 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
Drug Central 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O None
1551 9066 0 None 6 7 Bovine 8.2 pKi = 8.2 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
Drug Central 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
1961 9066 0 None 6 7 Bovine 8.2 pKi = 8.2 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
Drug Central 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
5311221 9066 0 None 6 7 Bovine 8.2 pKi = 8.2 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
Drug Central 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
CHEMBL1051 9066 0 None 6 7 Bovine 8.2 pKi = 8.2 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
Drug Central 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
DB00654 9066 0 None 6 7 Bovine 8.2 pKi = 8.2 Binding
Displacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membraneDisplacement of [3H]PGF2 alpha from FP receptor in bovine corpus luteum membrane
Drug Central 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O None
91798918 222842 0 None -3 10 Human 8.2 pKi = 8.2 Binding
NoneNone
Drug Central 400 10 2 6 2.6 COC(=O)CCC=C=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O None
5282226 224508 0 None -1 2 Human 8.1 pKi = 8.1 Binding
inhibition of [3H]AL-5848 binding to prostaglandin FP receptorinhibition of [3H]AL-5848 binding to prostaglandin FP receptor
Drug Central 500 12 3 6 4.4 CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COC1=CC(=CC=C1)C(F)(F)F None
91798918 222842 0 3H-PGF2Alpha -3 10 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase 400 10 2 6 2.6 COC(=O)CCC=C=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O None
1888 10672 29 3H-PGF2Alpha -354 17 Bovine 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
1974 10672 29 3H-PGF2Alpha -354 17 Bovine 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
5311493 10672 29 3H-PGF2Alpha -354 17 Bovine 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
CHEMBL521784 10672 29 3H-PGF2Alpha -354 17 Bovine 5.1 pKi = 5.1 Binding
NoneNone
PDSP KiDatabase 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O None
1817 9320 68 3H-PGF2Alpha -20 12 Human 5.0 pKi = 5.0 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
1936 9320 68 3H-PGF2Alpha -20 12 Human 5.0 pKi = 5.0 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
5282381 9320 68 3H-PGF2Alpha -20 12 Human 5.0 pKi = 5.0 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
CHEMBL606 9320 68 3H-PGF2Alpha -20 12 Human 5.0 pKi = 5.0 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
DB00929 9320 68 3H-PGF2Alpha -20 12 Human 5.0 pKi = 5.0 Binding
NoneNone
PDSP KiDatabase 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
None 222822 0 3H-PGF2Alpha -4 5 Mouse 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 366 12 2 3 5.2 CCCCCC(C=CC1CC2CC(C1CC=CCCCC(=O)O)S2)O None
None 222845 0 3H-PGF2Alpha 91 2 Bovine 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 390 12 4 4 3.3 C1C(C(C(C1O)CC=CCCCC(=O)O)CCC(CCC2=CC=CC=C2)O)O None
1551 9066 0 None -6 7 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O 10634944
1961 9066 0 None -6 7 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O 10634944
5311221 9066 0 None -6 7 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O 10634944
CHEMBL1051 9066 0 None -6 7 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O 10634944
DB00654 9066 0 None -6 7 Human 6.3 pKi = 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 432 13 3 5 4.2 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OC(C)C)O 10634944
10152528 7274 0 None - 1 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 515 7 1 5 4.7 O=C([C@@H]1SCCN1S(=O)(=O)c1ccc(cc1)c1ccccc1)N[C@@H](c1ccccn1)c1ccccc1 17618756
3424 7274 0 None - 1 Human 7.5 pKi = 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 515 7 1 5 4.7 O=C([C@@H]1SCCN1S(=O)(=O)c1ccc(cc1)c1ccccc1)N[C@@H](c1ccccn1)c1ccccc1 17618756
50902259 9713 1 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 482 10 2 6 4.2 CC(OC(=O)CCC[C@H]1CC[C@H]2[C@@H](OC1)C[C@H]([C@@H]2/C=C/[C@H](COc1cc(F)ccc1F)O)O)C 25788650
9875 9713 1 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 482 10 2 6 4.2 CC(OC(=O)CCC[C@H]1CC[C@H]2[C@@H](OC1)C[C@H]([C@@H]2/C=C/[C@H](COc1cc(F)ccc1F)O)O)C 25788650
CHEMBL4297633 9713 1 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 482 10 2 6 4.2 CC(OC(=O)CCC[C@H]1CC[C@H]2[C@@H](OC1)C[C@H]([C@@H]2/C=C/[C@H](COc1cc(F)ccc1F)O)O)C 25788650
DB12043 9713 1 None - 1 Human 7.8 pKi = 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 482 10 2 6 4.2 CC(OC(=O)CCC[C@H]1CC[C@H]2[C@@H](OC1)C[C@H]([C@@H]2/C=C/[C@H](COc1cc(F)ccc1F)O)O)C 25788650
1940 8444 41 None 1 10 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O 10634944
3417 8444 41 None 1 10 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O 10634944
5311100 8444 41 None 1 10 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O 10634944
CHEMBL1201379 8444 41 None 1 10 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O 10634944
DB11519 8444 41 None 1 10 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O 10634944
1960 9065 42 None 38 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 12 4 4 3.3 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O 10634944
6441636 9065 42 None 38 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 12 4 4 3.3 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O 10634944
CHEMBL1050 9065 42 None 38 2 Human 8.6 pKi = 8.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 390 12 4 4 3.3 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O 10634944
1817 9320 68 None -20 12 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
1936 9320 68 None -20 12 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
5282381 9320 68 None -20 12 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
CHEMBL606 9320 68 None -20 12 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
DB00929 9320 68 None -20 12 Human 8.3 pKi None 8.3 Binding
NoneNone
Drug Central 382 13 2 5 4.0 CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C None
1917 7714 0 None -9 9 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
5311044 7714 0 None -9 9 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
631 7714 0 None -9 9 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
CHEMBL160629 7714 0 None -9 9 Human 8.2 pKi None 8.2 Binding
NoneNone
Drug Central 374 6 3 4 2.2 CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C None
1907 9043 22 None -12589 2 Human 5.0 pKi None 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 4 1 3 5.5 OC(=O)C[C@@H]1CCn2c1c(Sc1ccc(cc1)Cl)c1c2cc(cc1)F 15755909
44403763 9043 22 None -12589 2 Human 5.0 pKi None 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 4 1 3 5.5 OC(=O)C[C@@H]1CCn2c1c(Sc1ccc(cc1)Cl)c1c2cc(cc1)F 15755909
CHEMBL370606 9043 22 None -12589 2 Human 5.0 pKi None 5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 375 4 1 3 5.5 OC(=O)C[C@@H]1CCn2c1c(Sc1ccc(cc1)Cl)c1c2cc(cc1)F 15755909
1893 7582 0 None -89 13 Mouse 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 9313928
5311242 7582 0 None -89 13 Mouse 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 9313928
CHEMBL148319 7582 0 None -89 13 Mouse 5.9 pKi None 5.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 9313928
1888 10672 29 None -39 17 Mouse 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 9313928
1974 10672 29 None -39 17 Mouse 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 9313928
5311493 10672 29 None -39 17 Mouse 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 9313928
CHEMBL521784 10672 29 None -39 17 Mouse 6.0 pKi None 6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 9313928
1895 8788 0 None -63 16 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
6435378 8788 0 None -63 16 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
CHEMBL236025 8788 0 None -63 16 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
DB01088 8788 0 None -63 16 Human 6.2 pKi None 6.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 360 8 3 3 3.5 CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C 10634944
1913 9242 0 None -3630 15 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 12 2 4 4.0 OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O 10634944
5311223 9242 0 None -3630 15 Human 6.3 pKi None 6.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 12 2 4 4.0 OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O 10634944
1893 7582 0 None -25 13 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 10634944
5311242 7582 0 None -25 13 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 10634944
CHEMBL148319 7582 0 None -25 13 Human 6.5 pKi None 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 10 3 3 4.1 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O 10634944
1888 10672 29 None -9 17 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
1974 10672 29 None -9 17 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
5311493 10672 29 None -9 17 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
CHEMBL521784 10672 29 None -9 17 Human 6.6 pKi None 6.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology 350 12 2 3 4.3 CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O 10634944
1883 9856 75 None -57 24 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10634944
1883 9856 75 None -57 24 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 12519077
1916 9856 75 None -57 24 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10634944
1916 9856 75 None -57 24 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 12519077
5280360 9856 75 None -57 24 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10634944
5280360 9856 75 None -57 24 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 12519077
913 9856 75 None -57 24 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10634944
913 9856 75 None -57 24 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 12519077
CHEMBL548 9856 75 None -57 24 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10634944
CHEMBL548 9856 75 None -57 24 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 12519077
DB00917 9856 75 None -57 24 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 10634944
DB00917 9856 75 None -57 24 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 12519077
1919 10476 0 None -575 7 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 12 3 7 1.7 O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O 10634944
2538 10476 0 None -575 7 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 12 3 7 1.7 O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O 10634944
5312153 10476 0 None -575 7 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 12 3 7 1.7 O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O 10634944
CHEMBL1472830 10476 0 None -575 7 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 12 3 7 1.7 O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O 10634944
DB12708 10476 0 None -575 7 Human 6.7 pKi None 6.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 465 12 3 7 1.7 O=C(NS(=O)(=O)C)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O 10634944
1913 9242 0 None -870 15 Mouse 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 12 2 4 4.0 OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O 9313928
5311223 9242 0 None -870 15 Mouse 6.9 pKi None 6.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology 374 12 2 4 4.0 OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O 9313928
1938 8750 18 None -199 4 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 512 11 2 4 4.6 OC(=O)CCC/C=C\C[C@H]1[C@@H]2CC[C@H]([C@@H]1/C=C/[C@H](COc1ccc(cc1)I)O)O2 9313928
5311175 8750 18 None -199 4 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 512 11 2 4 4.6 OC(=O)CCC/C=C\C[C@H]1[C@@H]2CC[C@H]([C@@H]1/C=C/[C@H](COc1ccc(cc1)I)O)O2 9313928
CHEMBL2113346 8750 18 None -199 4 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 512 11 2 4 4.6 OC(=O)CCC/C=C\C[C@H]1[C@@H]2CC[C@H]([C@@H]1/C=C/[C@H](COc1ccc(cc1)I)O)O2 9313928
1883 9856 75 None -41 24 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 9313928
1916 9856 75 None -41 24 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 9313928
5280360 9856 75 None -41 24 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 9313928
913 9856 75 None -41 24 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 9313928
CHEMBL548 9856 75 None -41 24 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 9313928
DB00917 9856 75 None -41 24 Mouse 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O 9313928
1918 8348 0 None -6 6 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 400 10 2 6 2.6 COC(=O)CCC=C=CC[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O 10634944
5311225 8348 0 None -6 6 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 400 10 2 6 2.6 COC(=O)CCC=C=CC[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O 10634944
CHEMBL2104194 8348 0 None -6 6 Human 7.1 pKi None 7.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology 400 10 2 6 2.6 COC(=O)CCC=C=CC[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](COc1ccccc1)O)O 10634944
1881 9853 0 None -22 21 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 9313928
1891 9853 0 None -22 21 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 9313928
448457 9853 0 None -22 21 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 9313928
CHEMBL1235252 9853 0 None -22 21 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 9313928
DB02056 9853 0 None -22 21 Mouse 7.3 pKi None 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 9313928
1881 9853 0 None -5 21 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 12519077
1891 9853 0 None -5 21 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 12519077
448457 9853 0 None -5 21 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 12519077
CHEMBL1235252 9853 0 None -5 21 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 12519077
DB02056 9853 0 None -5 21 Human 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 12 3 4 3.3 CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 12519077
1884 9857 52 None -4 22 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10634944
1884 9857 52 None -4 22 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 12519077
1884 9857 52 None -4 22 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 16604093
5280363 9857 52 None -4 22 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10634944
5280363 9857 52 None -4 22 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 12519077
5280363 9857 52 None -4 22 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 16604093
912 9857 52 None -4 22 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10634944
912 9857 52 None -4 22 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 12519077
912 9857 52 None -4 22 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 16604093
CHEMBL815 9857 52 None -4 22 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10634944
CHEMBL815 9857 52 None -4 22 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 12519077
CHEMBL815 9857 52 None -4 22 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 16604093
DB12789 9857 52 None -4 22 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 10634944
DB12789 9857 52 None -4 22 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 12519077
DB12789 9857 52 None -4 22 Human 8.2 pKi None 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 16604093
1940 8444 41 None -1 10 Mouse 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O 9313928
3417 8444 41 None -1 10 Mouse 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O 9313928
5311100 8444 41 None -1 10 Mouse 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O 9313928
CHEMBL1201379 8444 41 None -1 10 Mouse 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O 9313928
DB11519 8444 41 None -1 10 Mouse 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 458 11 4 5 3.6 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)C(F)(F)F)O)O 9313928
1884 9857 52 None 4 22 Mouse 8.5 pKi None 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 9313928
5280363 9857 52 None 4 22 Mouse 8.5 pKi None 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 9313928
912 9857 52 None 4 22 Mouse 8.5 pKi None 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 9313928
CHEMBL815 9857 52 None 4 22 Mouse 8.5 pKi None 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 9313928
DB12789 9857 52 None 4 22 Mouse 8.5 pKi None 8.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology 354 12 4 4 3.0 CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O 9313928
1894 7744 41 None 1 5 Human 9.3 pKi None 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10634944
5311053 7744 41 None 1 5 Human 9.3 pKi None 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10634944
CHEMBL37853 7744 41 None 1 5 Human 9.3 pKi None 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10634944
DB11507 7744 41 None 1 5 Human 9.3 pKi None 9.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology 424 11 4 5 3.2 OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O 10634944
11156438 9064 0 None 1 2 Human 8.1 pKi ~ 8.1 Binding
Value based on agonist activity of latanoprost.Value based on agonist activity of latanoprost.
Drug Central 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O None
5261 9064 0 None 1 2 Human 8.1 pKi ~ 8.1 Binding
Value based on agonist activity of latanoprost.Value based on agonist activity of latanoprost.
Drug Central 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O None
9635 9064 0 None 1 2 Human 8.1 pKi ~ 8.1 Binding
Value based on agonist activity of latanoprost.Value based on agonist activity of latanoprost.
Drug Central 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O None
CHEMBL2364612 9064 0 None 1 2 Human 8.1 pKi ~ 8.1 Binding
Value based on agonist activity of latanoprost.Value based on agonist activity of latanoprost.
Drug Central 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O None
DB11660 9064 0 None 1 2 Human 8.1 pKi ~ 8.1 Binding
Value based on agonist activity of latanoprost.Value based on agonist activity of latanoprost.
Drug Central 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O None
11156438 9064 0 None 1 2 Human 8.6 pKi ~ 8.6 Binding
Value based on agonist activity of latanoprost.Value based on agonist activity of latanoprost.
Guide to Pharmacology 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O 10634944
11156438 9064 0 None 1 2 Human 8.6 pKi ~ 8.6 Binding
Value based on agonist activity of latanoprost.Value based on agonist activity of latanoprost.
Guide to Pharmacology 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O 21396362
5261 9064 0 None 1 2 Human 8.6 pKi ~ 8.6 Binding
Value based on agonist activity of latanoprost.Value based on agonist activity of latanoprost.
Guide to Pharmacology 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O 10634944
5261 9064 0 None 1 2 Human 8.6 pKi ~ 8.6 Binding
Value based on agonist activity of latanoprost.Value based on agonist activity of latanoprost.
Guide to Pharmacology 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O 21396362
9635 9064 0 None 1 2 Human 8.6 pKi ~ 8.6 Binding
Value based on agonist activity of latanoprost.Value based on agonist activity of latanoprost.
Guide to Pharmacology 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O 10634944
9635 9064 0 None 1 2 Human 8.6 pKi ~ 8.6 Binding
Value based on agonist activity of latanoprost.Value based on agonist activity of latanoprost.
Guide to Pharmacology 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O 21396362
CHEMBL2364612 9064 0 None 1 2 Human 8.6 pKi ~ 8.6 Binding
Value based on agonist activity of latanoprost.Value based on agonist activity of latanoprost.
Guide to Pharmacology 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O 10634944
CHEMBL2364612 9064 0 None 1 2 Human 8.6 pKi ~ 8.6 Binding
Value based on agonist activity of latanoprost.Value based on agonist activity of latanoprost.
Guide to Pharmacology 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O 21396362
DB11660 9064 0 None 1 2 Human 8.6 pKi ~ 8.6 Binding
Value based on agonist activity of latanoprost.Value based on agonist activity of latanoprost.
Guide to Pharmacology 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O 10634944
DB11660 9064 0 None 1 2 Human 8.6 pKi ~ 8.6 Binding
Value based on agonist activity of latanoprost.Value based on agonist activity of latanoprost.
Guide to Pharmacology 507 18 3 8 3.8 O[C@@H](CCc1ccccc1)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])O 21396362