Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
71508233 | 93849 | 0 | None | 676 | 2 | Human | 10.6 | pEC50 | = | 10.6 | Functional | ChEMBL | 355 | 10 | 1 | 3 | 3.9 | CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1 | 10.1016/j.bmc.2012.10.060 | ||
CHEMBL2326201 | 93849 | 0 | None | 676 | 2 | Human | 10.6 | pEC50 | = | 10.6 | Functional | ChEMBL | 355 | 10 | 1 | 3 | 3.9 | CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1 | 10.1016/j.bmc.2012.10.060 | ||
139451781 | 191637 | 0 | None | 2 | 2 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 289 | 5 | 1 | 5 | 1.5 | CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3 | 10.1021/acs.jmedchem.0c00627 | ||
CHEMBL4852440 | 191637 | 0 | None | 2 | 2 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 289 | 5 | 1 | 5 | 1.5 | CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3 | 10.1021/acs.jmedchem.0c00627 | ||
46865422 | 93846 | 0 | None | 181 | 2 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 357 | 10 | 1 | 4 | 3.7 | CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1 | 10.1016/j.bmc.2012.10.060 | ||
CHEMBL2326199 | 93846 | 0 | None | 181 | 2 | Human | 10.3 | pEC50 | = | 10.3 | Functional | ChEMBL | 357 | 10 | 1 | 4 | 3.7 | CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1 | 10.1016/j.bmc.2012.10.060 | ||
139451764 | 193046 | 0 | None | 2 | 2 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 275 | 4 | 1 | 5 | 1.1 | COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3 | 10.1021/acs.jmedchem.0c00627 | ||
CHEMBL4873903 | 193046 | 0 | None | 2 | 2 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 275 | 4 | 1 | 5 | 1.1 | COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3 | 10.1021/acs.jmedchem.0c00627 | ||
1357 | 9263 | 139 | None | -1 | 5 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | ||
1672 | 9263 | 139 | None | -1 | 5 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | ||
224 | 9263 | 139 | None | -1 | 5 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | ||
896 | 9263 | 139 | None | -1 | 5 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | ||
CHEMBL45 | 9263 | 139 | None | -1 | 5 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | ||
DB01065 | 9263 | 139 | None | -1 | 5 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | ||
198 | 7101 | 126 | None | 3 | 4 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1039/C4MD00149D | ||
82148 | 7101 | 126 | None | 3 | 4 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1039/C4MD00149D | ||
99 | 7101 | 126 | None | 3 | 4 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1039/C4MD00149D | ||
CHEMBL10878 | 7101 | 126 | None | 3 | 4 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1039/C4MD00149D | ||
DB06594 | 7101 | 126 | None | 3 | 4 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1039/C4MD00149D | ||
1357 | 9263 | 139 | None | -1 | 5 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c00627 | ||
1672 | 9263 | 139 | None | -1 | 5 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c00627 | ||
224 | 9263 | 139 | None | -1 | 5 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c00627 | ||
896 | 9263 | 139 | None | -1 | 5 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c00627 | ||
CHEMBL45 | 9263 | 139 | None | -1 | 5 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c00627 | ||
DB01065 | 9263 | 139 | None | -1 | 5 | Human | 10.2 | pEC50 | = | 10.2 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c00627 | ||
139451763 | 193112 | 0 | None | 1 | 2 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 305 | 8 | 1 | 5 | 2.4 | CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21 | 10.1021/acs.jmedchem.0c00627 | ||
CHEMBL4874954 | 193112 | 0 | None | 1 | 2 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 305 | 8 | 1 | 5 | 2.4 | CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21 | 10.1021/acs.jmedchem.0c00627 | ||
137647756 | 164723 | 0 | None | 213 | 2 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 259 | 4 | 2 | 3 | 1.7 | CNC(=O)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | ||
CHEMBL4084612 | 164723 | 0 | None | 213 | 2 | Human | 10.1 | pEC50 | = | 10.1 | Functional | ChEMBL | 259 | 4 | 2 | 3 | 1.7 | CNC(=O)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | ||
9839629 | 106892 | 0 | None | 1 | 2 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 309 | 5 | 1 | 3 | 3.8 | COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | ||
CHEMBL287560 | 106892 | 0 | None | 1 | 2 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 309 | 5 | 1 | 3 | 3.8 | COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | ||
198 | 7101 | 126 | None | 3 | 4 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmc.2010.04.008 | ||
82148 | 7101 | 126 | None | 3 | 4 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmc.2010.04.008 | ||
99 | 7101 | 126 | None | 3 | 4 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmc.2010.04.008 | ||
CHEMBL10878 | 7101 | 126 | None | 3 | 4 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmc.2010.04.008 | ||
DB06594 | 7101 | 126 | None | 3 | 4 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmc.2010.04.008 | ||
198 | 7101 | 126 | None | 3 | 4 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmc.2008.08.052 | ||
82148 | 7101 | 126 | None | 3 | 4 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmc.2008.08.052 | ||
99 | 7101 | 126 | None | 3 | 4 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmc.2008.08.052 | ||
CHEMBL10878 | 7101 | 126 | None | 3 | 4 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmc.2008.08.052 | ||
DB06594 | 7101 | 126 | None | 3 | 4 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmc.2008.08.052 | ||
198 | 7101 | 126 | None | 3 | 4 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1021/jm0255872 | ||
82148 | 7101 | 126 | None | 3 | 4 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1021/jm0255872 | ||
99 | 7101 | 126 | None | 3 | 4 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1021/jm0255872 | ||
CHEMBL10878 | 7101 | 126 | None | 3 | 4 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1021/jm0255872 | ||
DB06594 | 7101 | 126 | None | 3 | 4 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1021/jm0255872 | ||
137655238 | 165664 | 0 | None | 891 | 2 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 275 | 4 | 2 | 3 | 1.9 | CNC(=S)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | ||
CHEMBL4095210 | 165664 | 0 | None | 891 | 2 | Human | 10.0 | pEC50 | = | 10 | Functional | ChEMBL | 275 | 4 | 2 | 3 | 1.9 | CNC(=S)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | ||
71508232 | 93848 | 0 | None | 75 | 2 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 351 | 7 | 1 | 3 | 3.6 | CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1 | 10.1016/j.bmc.2012.10.060 | ||
CHEMBL2326200 | 93848 | 0 | None | 75 | 2 | Human | 10.0 | pEC50 | = | 10.0 | Functional | ChEMBL | 351 | 7 | 1 | 3 | 3.6 | CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1 | 10.1016/j.bmc.2012.10.060 | ||
10926138 | 214756 | 0 | None | 147 | 2 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 349 | 8 | 1 | 3 | 4.3 | C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | ||
CHEMBL97186 | 214756 | 0 | None | 147 | 2 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 349 | 8 | 1 | 3 | 4.3 | C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | ||
1357 | 9263 | 139 | None | -1 | 5 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.2c00717 | ||
1672 | 9263 | 139 | None | -1 | 5 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.2c00717 | ||
224 | 9263 | 139 | None | -1 | 5 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.2c00717 | ||
896 | 9263 | 139 | None | -1 | 5 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.2c00717 | ||
CHEMBL45 | 9263 | 139 | None | -1 | 5 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.2c00717 | ||
DB01065 | 9263 | 139 | None | -1 | 5 | Human | 9.8 | pEC50 | = | 9.8 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.2c00717 | ||
198 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2017.10.025 | ||
82148 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2017.10.025 | ||
99 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL10878 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2017.10.025 | ||
DB06594 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2017.10.025 | ||
198 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2015.12.047 | ||
198 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2016.12.013 | ||
82148 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2015.12.047 | ||
82148 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2016.12.013 | ||
99 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2015.12.047 | ||
99 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2016.12.013 | ||
CHEMBL10878 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2015.12.047 | ||
CHEMBL10878 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2016.12.013 | ||
DB06594 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2015.12.047 | ||
DB06594 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2016.12.013 | ||
139451769 | 192921 | 0 | None | 5 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 291 | 7 | 1 | 5 | 2.0 | CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC | 10.1021/acs.jmedchem.0c00627 | ||
CHEMBL4872217 | 192921 | 0 | None | 5 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 291 | 7 | 1 | 5 | 2.0 | CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC | 10.1021/acs.jmedchem.0c00627 | ||
145982070 | 173254 | 0 | None | -1 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 283 | 3 | 1 | 2 | 3.2 | COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4278248 | 173254 | 0 | None | -1 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 283 | 3 | 1 | 2 | 3.2 | COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | ||
145986532 | 174060 | 0 | None | 4 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 269 | 3 | 1 | 2 | 3.0 | COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4293386 | 174060 | 0 | None | 4 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 269 | 3 | 1 | 2 | 3.0 | COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | ||
71508235 | 93850 | 0 | None | 14 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 327 | 8 | 1 | 3 | 3.8 | CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1 | 10.1016/j.bmc.2012.10.060 | ||
CHEMBL2326203 | 93850 | 0 | None | 14 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 327 | 8 | 1 | 3 | 3.8 | CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1 | 10.1016/j.bmc.2012.10.060 | ||
137636213 | 162865 | 0 | None | 47 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 273 | 5 | 2 | 3 | 2.1 | CCNC(=O)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | ||
CHEMBL4062947 | 162865 | 0 | None | 47 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 273 | 5 | 2 | 3 | 2.1 | CCNC(=O)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | ||
137639112 | 163631 | 0 | None | 8128 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 245 | 4 | 2 | 3 | 1.5 | COc1ccc2cccc(CCNC(N)=O)c2n1 | 10.1016/j.ejmech.2016.12.013 | ||
CHEMBL4071572 | 163631 | 0 | None | 8128 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 245 | 4 | 2 | 3 | 1.5 | COc1ccc2cccc(CCNC(N)=O)c2n1 | 10.1016/j.ejmech.2016.12.013 | ||
137660333 | 166299 | 0 | None | 3 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 244 | 4 | 1 | 3 | 1.9 | COc1ccc2cccc(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.12.013 | ||
CHEMBL4102177 | 166299 | 0 | None | 3 | 2 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 244 | 4 | 1 | 3 | 1.9 | COc1ccc2cccc(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.12.013 | ||
198 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2020.112078 | ||
82148 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2020.112078 | ||
99 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2020.112078 | ||
CHEMBL10878 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2020.112078 | ||
DB06594 | 7101 | 126 | None | 3 | 4 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2020.112078 | ||
71508234 | 7492 | 0 | None | 173 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 341 | 9 | 1 | 3 | 3.8 | CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC | 10.1016/j.bmc.2012.10.060 | ||
7924 | 7492 | 0 | None | 173 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 341 | 9 | 1 | 3 | 3.8 | CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC | 10.1016/j.bmc.2012.10.060 | ||
CHEMBL2326202 | 7492 | 0 | None | 173 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 341 | 9 | 1 | 3 | 3.8 | CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC | 10.1016/j.bmc.2012.10.060 | ||
139451795 | 192108 | 0 | None | -2 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 277 | 6 | 1 | 5 | 1.6 | CCOc1nc2ccc(OC)cc2n1CCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | ||
CHEMBL4859677 | 192108 | 0 | None | -2 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 277 | 6 | 1 | 5 | 1.6 | CCOc1nc2ccc(OC)cc2n1CCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | ||
139451757 | 191610 | 0 | None | -3 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 311 | 6 | 1 | 5 | 2.2 | CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | ||
CHEMBL4852096 | 191610 | 0 | None | -3 | 2 | Human | 9.6 | pEC50 | = | 9.6 | Functional | ChEMBL | 311 | 6 | 1 | 5 | 2.2 | CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | ||
145990662 | 173708 | 0 | None | 16 | 2 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 312 | 4 | 2 | 2 | 3.4 | CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4286896 | 173708 | 0 | None | 16 | 2 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 312 | 4 | 2 | 2 | 3.4 | CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
139451766 | 191226 | 0 | None | 4 | 2 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 325 | 7 | 1 | 5 | 2.6 | CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | ||
CHEMBL4846505 | 191226 | 0 | None | 4 | 2 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 325 | 7 | 1 | 5 | 2.6 | CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | ||
139451761 | 191376 | 0 | None | -4 | 2 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 291 | 7 | 1 | 5 | 2.0 | CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | ||
CHEMBL4848885 | 191376 | 0 | None | -4 | 2 | Human | 9.5 | pEC50 | = | 9.5 | Functional | ChEMBL | 291 | 7 | 1 | 5 | 2.0 | CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | ||
122220128 | 166454 | 0 | None | 27 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 309 | 6 | 2 | 3 | 2.3 | COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1 | 10.1039/C4MD00149D | ||
CHEMBL4104020 | 166454 | 0 | None | 27 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 309 | 6 | 2 | 3 | 2.3 | COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1 | 10.1039/C4MD00149D | ||
10385056 | 119013 | 0 | None | 354 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 379 | 9 | 1 | 4 | 4.3 | C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | ||
CHEMBL329086 | 119013 | 0 | None | 354 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 379 | 9 | 1 | 4 | 4.3 | C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | ||
145988741 | 174015 | 0 | None | 12 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 299 | 5 | 1 | 3 | 2.6 | COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4292336 | 174015 | 0 | None | 12 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 299 | 5 | 1 | 3 | 2.6 | COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
137645530 | 164502 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 260 | 4 | 1 | 4 | 2.1 | COC(=O)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | ||
CHEMBL4082097 | 164502 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 260 | 4 | 1 | 4 | 2.1 | COC(=O)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | ||
11824364 | 119329 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1ccc2oc(Cc3ccccc3OC)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | ||
CHEMBL329960 | 119329 | 0 | None | - | 1 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1ccc2oc(Cc3ccccc3OC)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | ||
164946945 | 197008 | 1 | None | 3 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 427 | 9 | 1 | 7 | 3.3 | COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | ||
CHEMBL5174929 | 197008 | 1 | None | 3 | 2 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 427 | 9 | 1 | 7 | 3.3 | COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | ||
1357 | 9263 | 139 | None | -1 | 5 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2011.02.097 | ||
1672 | 9263 | 139 | None | -1 | 5 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2011.02.097 | ||
224 | 9263 | 139 | None | -1 | 5 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2011.02.097 | ||
896 | 9263 | 139 | None | -1 | 5 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2011.02.097 | ||
CHEMBL45 | 9263 | 139 | None | -1 | 5 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2011.02.097 | ||
DB01065 | 9263 | 139 | None | -1 | 5 | Human | 9.4 | pEC50 | = | 9.4 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2011.02.097 | ||
1357 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0005252 | ||
1672 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0005252 | ||
224 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0005252 | ||
896 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0005252 | ||
CHEMBL45 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0005252 | ||
DB01065 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0005252 | ||
1357 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2010.04.008 | ||
1672 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2010.04.008 | ||
224 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2010.04.008 | ||
896 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2010.04.008 | ||
CHEMBL45 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2010.04.008 | ||
DB01065 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2010.04.008 | ||
1357 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.08.052 | ||
1672 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.08.052 | ||
224 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.08.052 | ||
896 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.08.052 | ||
CHEMBL45 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.08.052 | ||
DB01065 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.08.052 | ||
1357 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0255872 | ||
1672 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0255872 | ||
224 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0255872 | ||
896 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0255872 | ||
CHEMBL45 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0255872 | ||
DB01065 | 9263 | 139 | None | -1 | 5 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0255872 | ||
44579115 | 188614 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 348 | 6 | 2 | 3 | 4.2 | CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 | 10.1016/j.bmc.2008.08.052 | ||
CHEMBL477835 | 188614 | 0 | None | - | 1 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 348 | 6 | 2 | 3 | 4.2 | CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 | 10.1016/j.bmc.2008.08.052 | ||
57781216 | 132625 | 0 | None | -8 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 258 | 3 | 1 | 3 | 2.7 | CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21 | 10.1021/acs.jmedchem.0c01836 | ||
CHEMBL3648356 | 132625 | 0 | None | -8 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 258 | 3 | 1 | 3 | 2.7 | CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21 | 10.1021/acs.jmedchem.0c01836 | ||
139451767 | 191783 | 0 | None | -5 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 263 | 5 | 1 | 5 | 1.2 | COc1ccc2nc(OC)n(CCNC(C)=O)c2c1 | 10.1021/acs.jmedchem.0c00627 | ||
CHEMBL4854625 | 191783 | 0 | None | -5 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 263 | 5 | 1 | 5 | 1.2 | COc1ccc2nc(OC)n(CCNC(C)=O)c2c1 | 10.1021/acs.jmedchem.0c00627 | ||
24954989 | 8314 | 1 | None | -25 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 273 | 4 | 1 | 4 | 1.5 | CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2 | 10.1021/jm200385u | ||
7774 | 8314 | 1 | None | -25 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 273 | 4 | 1 | 4 | 1.5 | CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2 | 10.1021/jm200385u | ||
CHEMBL1802025 | 8314 | 1 | None | -25 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 273 | 4 | 1 | 4 | 1.5 | CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2 | 10.1021/jm200385u | ||
139451780 | 192723 | 0 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 303 | 7 | 1 | 5 | 2.0 | CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1 | 10.1021/acs.jmedchem.0c00627 | ||
CHEMBL4869463 | 192723 | 0 | None | 1 | 2 | Human | 9.3 | pEC50 | = | 9.3 | Functional | ChEMBL | 303 | 7 | 1 | 5 | 2.0 | CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1 | 10.1021/acs.jmedchem.0c00627 | ||
145982333 | 173336 | 0 | None | 2 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 284 | 3 | 2 | 2 | 2.8 | CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4279639 | 173336 | 0 | None | 2 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 284 | 3 | 2 | 2 | 2.8 | CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
12985495 | 188165 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 377 | 8 | 2 | 3 | 4.5 | CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 | 10.1016/j.bmc.2008.08.052 | ||
CHEMBL476341 | 188165 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 377 | 8 | 2 | 3 | 4.5 | CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 | 10.1016/j.bmc.2008.08.052 | ||
23642307 | 165674 | 1 | None | 39 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 291 | 6 | 2 | 3 | 2.0 | COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1 | 10.1039/C4MD00149D | ||
CHEMBL4095334 | 165674 | 1 | None | 39 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 291 | 6 | 2 | 3 | 2.0 | COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1 | 10.1039/C4MD00149D | ||
53231366 | 69175 | 0 | None | 309 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 363 | 5 | 1 | 3 | 5.0 | CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | ||
CHEMBL1779804 | 69175 | 0 | None | 309 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 363 | 5 | 1 | 3 | 5.0 | CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | ||
168296374 | 199297 | 0 | None | -9 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 505 | 9 | 1 | 8 | 4.5 | CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1 | 10.1021/acs.jmedchem.2c00717 | ||
CHEMBL5209359 | 199297 | 0 | None | -9 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 505 | 9 | 1 | 8 | 4.5 | CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1 | 10.1021/acs.jmedchem.2c00717 | ||
53231465 | 69174 | 0 | None | 35 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 237 | 3 | 1 | 2 | 2.7 | CC(=O)NCCc1csc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | ||
CHEMBL1779803 | 69174 | 0 | None | 35 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 237 | 3 | 1 | 2 | 2.7 | CC(=O)NCCc1csc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | ||
145988269 | 173969 | 0 | None | 12 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 326 | 5 | 2 | 2 | 3.8 | CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4291381 | 173969 | 0 | None | 12 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 326 | 5 | 2 | 2 | 3.8 | CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
52918079 | 67529 | 0 | None | 2 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 261 | 6 | 1 | 4 | 2.0 | CCCC(=O)NCCn1ccc2ccc(OC)nc21 | 10.1016/j.bmcl.2011.02.097 | ||
CHEMBL1760947 | 67529 | 0 | None | 2 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 261 | 6 | 1 | 4 | 2.0 | CCCC(=O)NCCn1ccc2ccc(OC)nc21 | 10.1016/j.bmcl.2011.02.097 | ||
12985494 | 197408 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 363 | 7 | 2 | 3 | 4.1 | CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 | 10.1016/j.bmc.2008.08.052 | ||
CHEMBL518113 | 197408 | 0 | None | - | 1 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 363 | 7 | 2 | 3 | 4.1 | CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 | 10.1016/j.bmc.2008.08.052 | ||
127026423 | 144597 | 0 | None | 6 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 283 | 4 | 1 | 3 | 3.3 | COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
CHEMBL3759802 | 144597 | 0 | None | 6 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 283 | 4 | 1 | 3 | 3.3 | COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
137650611 | 164291 | 0 | None | 91 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 244 | 4 | 1 | 3 | 1.9 | CNC(=O)CCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | ||
CHEMBL4079784 | 164291 | 0 | None | 91 | 2 | Human | 9.2 | pEC50 | = | 9.2 | Functional | ChEMBL | 244 | 4 | 1 | 3 | 1.9 | CNC(=O)CCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | ||
1353 | 10208 | 5 | None | 51 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC | 10.1021/jm0005252 | ||
9998187 | 10208 | 5 | None | 51 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC | 10.1021/jm0005252 | ||
CHEMBL33549 | 10208 | 5 | None | 51 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC | 10.1021/jm0005252 | ||
10400294 | 25321 | 0 | None | - | 1 | Rat | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 258 | 5 | 1 | 3 | 2.6 | Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1 | 10.1016/j.bmcl.2004.04.082 | ||
CHEMBL127570 | 25321 | 0 | None | - | 1 | Rat | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 258 | 5 | 1 | 3 | 2.6 | Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1 | 10.1016/j.bmcl.2004.04.082 | ||
139451799 | 192618 | 0 | None | -3 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 279 | 5 | 1 | 5 | 1.9 | COc1ccc2nc(SC)n(CCNC(C)=O)c2c1 | 10.1021/acs.jmedchem.0c00627 | ||
CHEMBL4867553 | 192618 | 0 | None | -3 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 279 | 5 | 1 | 5 | 1.9 | COc1ccc2nc(SC)n(CCNC(C)=O)c2c1 | 10.1021/acs.jmedchem.0c00627 | ||
7922 | 8737 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO | 10.1016/j.bmc.2008.08.052 | ||
9798456 | 8737 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO | 10.1016/j.bmc.2008.08.052 | ||
CHEMBL476131 | 8737 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO | 10.1016/j.bmc.2008.08.052 | ||
23658144 | 164958 | 1 | None | 100 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 291 | 6 | 2 | 3 | 2.0 | COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1 | 10.1039/C4MD00149D | ||
CHEMBL4087633 | 164958 | 1 | None | 100 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 291 | 6 | 2 | 3 | 2.0 | COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1 | 10.1039/C4MD00149D | ||
137642160 | 165171 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 308 | 5 | 1 | 5 | 1.3 | COc1ccc2cccc(CCC(=O)NS(C)(=O)=O)c2n1 | 10.1016/j.ejmech.2016.12.013 | ||
CHEMBL4089965 | 165171 | 0 | None | - | 1 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 308 | 5 | 1 | 5 | 1.3 | COc1ccc2cccc(CCC(=O)NS(C)(=O)=O)c2n1 | 10.1016/j.ejmech.2016.12.013 | ||
1357 | 9263 | 139 | None | -1 | 5 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200385u | ||
1672 | 9263 | 139 | None | -1 | 5 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200385u | ||
224 | 9263 | 139 | None | -1 | 5 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200385u | ||
896 | 9263 | 139 | None | -1 | 5 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200385u | ||
CHEMBL45 | 9263 | 139 | None | -1 | 5 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200385u | ||
DB01065 | 9263 | 139 | None | -1 | 5 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200385u | ||
1357 | 9263 | 139 | None | -1 | 5 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c01836 | ||
1672 | 9263 | 139 | None | -1 | 5 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c01836 | ||
224 | 9263 | 139 | None | -1 | 5 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c01836 | ||
896 | 9263 | 139 | None | -1 | 5 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c01836 | ||
CHEMBL45 | 9263 | 139 | None | -1 | 5 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c01836 | ||
DB01065 | 9263 | 139 | None | -1 | 5 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c01836 | ||
1357 | 9263 | 139 | None | -1 | 5 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200221q | ||
1672 | 9263 | 139 | None | -1 | 5 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200221q | ||
224 | 9263 | 139 | None | -1 | 5 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200221q | ||
896 | 9263 | 139 | None | -1 | 5 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200221q | ||
CHEMBL45 | 9263 | 139 | None | -1 | 5 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200221q | ||
DB01065 | 9263 | 139 | None | -1 | 5 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200221q | ||
139451790 | 192075 | 18 | None | -6 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 297 | 5 | 1 | 5 | 1.8 | COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | ||
CHEMBL4859295 | 192075 | 18 | None | -6 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 297 | 5 | 1 | 5 | 1.8 | COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | ||
145981162 | 173276 | 0 | None | 2 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 270 | 3 | 2 | 2 | 2.5 | COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4278575 | 173276 | 0 | None | 2 | 2 | Human | 9.1 | pEC50 | = | 9.1 | Functional | ChEMBL | 270 | 3 | 2 | 2 | 2.5 | COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | ||
127026427 | 144462 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 295 | 4 | 1 | 3 | 3.6 | COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
CHEMBL3758679 | 144462 | 0 | None | 1 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 295 | 4 | 1 | 3 | 3.6 | COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
127026062 | 144467 | 0 | None | 7 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 269 | 3 | 1 | 3 | 3.2 | COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
CHEMBL3758717 | 144467 | 0 | None | 7 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 269 | 3 | 1 | 3 | 3.2 | COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
145982167 | 173390 | 0 | None | 3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 305 | 4 | 1 | 3 | 2.4 | COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4280601 | 173390 | 0 | None | 3 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 305 | 4 | 1 | 3 | 2.4 | COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | ||
12985491 | 193759 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 411 | 6 | 1 | 2 | 5.1 | COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | ||
CHEMBL490595 | 193759 | 0 | None | - | 1 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 411 | 6 | 1 | 2 | 5.1 | COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | ||
137637884 | 163025 | 0 | None | 19 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 280 | 3 | 1 | 2 | 3.3 | CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | ||
CHEMBL4064813 | 163025 | 0 | None | 19 | 2 | Human | 9.0 | pEC50 | = | 9 | Functional | ChEMBL | 280 | 3 | 1 | 2 | 3.3 | CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | ||
21581654 | 67526 | 1 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 233 | 4 | 2 | 3 | 1.3 | COc1ccc2[nH]cc(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | ||
CHEMBL1760944 | 67526 | 1 | None | 10 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 233 | 4 | 2 | 3 | 1.3 | COc1ccc2[nH]cc(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | ||
127025784 | 144511 | 0 | None | 8 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 287 | 4 | 1 | 3 | 3.2 | COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
CHEMBL3759084 | 144511 | 0 | None | 8 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 287 | 4 | 1 | 3 | 3.2 | COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
137650826 | 164284 | 0 | None | 28 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 289 | 5 | 2 | 3 | 2.3 | CCNC(=S)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | ||
CHEMBL4079699 | 164284 | 0 | None | 28 | 2 | Human | 9.0 | pEC50 | = | 9.0 | Functional | ChEMBL | 289 | 5 | 2 | 3 | 2.3 | CCNC(=S)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | ||
23658146 | 163897 | 1 | None | 15 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 287 | 6 | 2 | 3 | 2.5 | CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12 | 10.1039/C4MD00149D | ||
CHEMBL4074895 | 163897 | 1 | None | 15 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 287 | 6 | 2 | 3 | 2.5 | CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12 | 10.1039/C4MD00149D | ||
11784134 | 113726 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 391 | 6 | 1 | 3 | 4.7 | COc1ccc2oc(Cc3cccc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | ||
CHEMBL314947 | 113726 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 391 | 6 | 1 | 3 | 4.7 | COc1ccc2oc(Cc3cccc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | ||
168274836 | 196926 | 0 | None | -17 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 411 | 7 | 1 | 7 | 3.4 | COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | ||
CHEMBL5173623 | 196926 | 0 | None | -17 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 411 | 7 | 1 | 7 | 3.4 | COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | ||
52918080 | 67538 | 0 | None | 12 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 287 | 4 | 1 | 4 | 2.1 | COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3 | 10.1016/j.bmcl.2011.02.097 | ||
CHEMBL1760957 | 67538 | 0 | None | 12 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 287 | 4 | 1 | 4 | 2.1 | COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3 | 10.1016/j.bmcl.2011.02.097 | ||
1354 | 10209 | 15 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 334 | 5 | 2 | 3 | 3.8 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N | 10.1016/j.bmc.2008.08.052 | ||
22133318 | 10209 | 15 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 334 | 5 | 2 | 3 | 3.8 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N | 10.1016/j.bmc.2008.08.052 | ||
CHEMBL490188 | 10209 | 15 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 334 | 5 | 2 | 3 | 3.8 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N | 10.1016/j.bmc.2008.08.052 | ||
44579259 | 193893 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 347 | 6 | 1 | 3 | 4.0 | COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | ||
CHEMBL491604 | 193893 | 0 | None | - | 1 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 347 | 6 | 1 | 3 | 4.0 | COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | ||
53238181 | 7721 | 0 | None | 3 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 339 | 5 | 1 | 2 | 4.4 | CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2 | 10.1021/jm200221q | ||
7780 | 7721 | 0 | None | 3 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 339 | 5 | 1 | 2 | 4.4 | CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2 | 10.1021/jm200221q | ||
CHEMBL1774519 | 7721 | 0 | None | 3 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 339 | 5 | 1 | 2 | 4.4 | CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2 | 10.1021/jm200221q | ||
52918078 | 67528 | 0 | None | 3 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 247 | 5 | 1 | 4 | 1.6 | CCC(=O)NCCn1ccc2ccc(OC)nc21 | 10.1016/j.bmcl.2011.02.097 | ||
CHEMBL1760946 | 67528 | 0 | None | 3 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 247 | 5 | 1 | 4 | 1.6 | CCC(=O)NCCn1ccc2ccc(OC)nc21 | 10.1016/j.bmcl.2011.02.097 | ||
127029516 | 144412 | 0 | None | 3 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 269 | 3 | 1 | 3 | 3.2 | COc1ccc2ccc3occ(CNC(C)=O)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
CHEMBL3758225 | 144412 | 0 | None | 3 | 2 | Human | 8.9 | pEC50 | = | 8.9 | Functional | ChEMBL | 269 | 3 | 1 | 3 | 3.2 | COc1ccc2ccc3occ(CNC(C)=O)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
44579163 | 188908 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 362 | 6 | 1 | 3 | 4.3 | COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | ||
CHEMBL478217 | 188908 | 0 | None | - | 1 | Human | 8.8 | pEC50 | = | 8.8 | Functional | ChEMBL | 362 | 6 | 1 | 3 | 4.3 | COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | ||
54582195 | 67536 | 0 | None | 9 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 329 | 5 | 1 | 5 | 1.9 | COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | ||
CHEMBL1760955 | 67536 | 0 | None | 9 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 329 | 5 | 1 | 5 | 1.9 | COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | ||
127025787 | 144510 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 298 | 4 | 2 | 3 | 3.4 | CCNC(=O)NCc1cc2c(ccc3ccc(OC)cc32)o1 | 10.1016/j.ejmech.2015.12.047 | ||
CHEMBL3759080 | 144510 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 298 | 4 | 2 | 3 | 3.4 | CCNC(=O)NCc1cc2c(ccc3ccc(OC)cc32)o1 | 10.1016/j.ejmech.2015.12.047 | ||
137653199 | 165402 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 218 | 2 | 1 | 2 | 1.4 | CC(=O)NCC1Cc2ccccc2N(C)C1 | 10.1021/acs.jmedchem.8b00359 | ||
CHEMBL4092308 | 165402 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 218 | 2 | 1 | 2 | 1.4 | CC(=O)NCC1Cc2ccccc2N(C)C1 | 10.1021/acs.jmedchem.8b00359 | ||
10925526 | 119111 | 0 | None | 47 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 329 | 6 | 1 | 3 | 4.2 | COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | ||
CHEMBL329299 | 119111 | 0 | None | 47 | 2 | Human | 8.0 | pEC50 | = | 8 | Functional | ChEMBL | 329 | 6 | 1 | 3 | 4.2 | COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | ||
145991111 | 173691 | 0 | None | 10 | 2 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 319 | 5 | 1 | 3 | 2.8 | CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4286494 | 173691 | 0 | None | 10 | 2 | Human | 6.0 | pEC50 | = | 6 | Functional | ChEMBL | 319 | 5 | 1 | 3 | 2.8 | CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
122178510 | 128108 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 275 | 4 | 2 | 4 | 3.0 | COc1ccc2[nH]cc(CCc3n[nH]c(=S)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | ||
CHEMBL3580921 | 128108 | 0 | None | - | 1 | Human | 6.0 | pEC50 | = | 6.0 | Functional | ChEMBL | 275 | 4 | 2 | 4 | 3.0 | COc1ccc2[nH]cc(CCc3n[nH]c(=S)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | ||
54581170 | 67537 | 0 | None | 2 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 359 | 4 | 1 | 4 | 1.8 | COc1ccc2c(I)cn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | ||
CHEMBL1760956 | 67537 | 0 | None | 2 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 359 | 4 | 1 | 4 | 1.8 | COc1ccc2c(I)cn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | ||
86273228 | 128098 | 0 | None | 18 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 258 | 6 | 2 | 2 | 2.4 | C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12 | 10.1021/acs.jmedchem.5b00245 | ||
CHEMBL3580910 | 128098 | 0 | None | 18 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 258 | 6 | 2 | 2 | 2.4 | C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12 | 10.1021/acs.jmedchem.5b00245 | ||
122178513 | 128111 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 288 | 5 | 2 | 5 | 3.1 | CCNc1nnc(Cc2c[nH]c3ccc(OC)cc23)s1 | 10.1021/acs.jmedchem.5b00245 | ||
CHEMBL3580926 | 128111 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 288 | 5 | 2 | 5 | 3.1 | CCNc1nnc(Cc2c[nH]c3ccc(OC)cc23)s1 | 10.1021/acs.jmedchem.5b00245 | ||
145 | 6928 | 49 | None | -63 | 11 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | ||
1832 | 6928 | 49 | None | -63 | 11 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | ||
CHEMBL7257 | 6928 | 49 | None | -63 | 11 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | ||
DB14010 | 6928 | 49 | None | -63 | 11 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | ||
49862736 | 21909 | 0 | None | -117 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 569 | 3 | 0 | 4 | 6.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | ||
CHEMBL1209787 | 21909 | 0 | None | -117 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 569 | 3 | 0 | 4 | 6.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)C)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | ||
162663385 | 188777 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 271 | 5 | 1 | 4 | 1.7 | COc1ccc2cnnc(CCNC(=O)C3CC3)c2c1 | 10.1016/j.ejmech.2020.112078 | ||
CHEMBL4780509 | 188777 | 0 | None | - | 1 | Human | 5.9 | pEC50 | = | 5.9 | Functional | ChEMBL | 271 | 5 | 1 | 4 | 1.7 | COc1ccc2cnnc(CCNC(=O)C3CC3)c2c1 | 10.1016/j.ejmech.2020.112078 | ||
86273229 | 128097 | 1 | None | 3 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 244 | 5 | 2 | 2 | 2.0 | C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12 | 10.1021/acs.jmedchem.5b00245 | ||
CHEMBL3580909 | 128097 | 1 | None | 3 | 2 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 244 | 5 | 2 | 2 | 2.0 | C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12 | 10.1021/acs.jmedchem.5b00245 | ||
9850873 | 15639 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 564 | 15 | 2 | 4 | 6.4 | O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12)C1CC1 | 10.1016/j.bmc.2010.04.008 | ||
CHEMBL1097314 | 15639 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 564 | 15 | 2 | 4 | 6.4 | O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12)C1CC1 | 10.1016/j.bmc.2010.04.008 | ||
44359437 | 36673 | 0 | None | -3 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 273 | 5 | 2 | 3 | 2.1 | COc1ccc2cccc(C(CO)CNC(C)=O)c2c1 | 10.1039/C4MD00149D | ||
CHEMBL138807 | 36673 | 0 | None | -3 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 273 | 5 | 2 | 3 | 2.1 | COc1ccc2cccc(C(CO)CNC(C)=O)c2c1 | 10.1039/C4MD00149D | ||
81689735 | 128103 | 0 | None | -1 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 257 | 4 | 1 | 4 | 2.7 | COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | ||
CHEMBL3580916 | 128103 | 0 | None | -1 | 2 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 257 | 4 | 1 | 4 | 2.7 | COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | ||
46845151 | 15438 | 0 | None | -7 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 499 | 12 | 2 | 4 | 6.1 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12 | 10.1016/j.bmc.2010.04.008 | ||
CHEMBL1095505 | 15438 | 0 | None | -7 | 2 | Human | 6.8 | pEC50 | = | 6.8 | Functional | ChEMBL | 499 | 12 | 2 | 4 | 6.1 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12 | 10.1016/j.bmc.2010.04.008 | ||
46919520 | 21910 | 0 | None | -1479 | 6 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 597 | 4 | 0 | 5 | 6.3 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | ||
CHEMBL1209788 | 21910 | 0 | None | -1479 | 6 | Human | 5.8 | pEC50 | = | 5.8 | Functional | ChEMBL | 597 | 4 | 0 | 5 | 6.3 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | ||
11078652 | 214697 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 351 | 7 | 1 | 3 | 4.3 | CCc1ccc2oc(Cc3cccc(OC)c3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | ||
CHEMBL96778 | 214697 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 351 | 7 | 1 | 3 | 4.3 | CCc1ccc2oc(Cc3cccc(OC)c3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | ||
168274836 | 196926 | 0 | None | -17 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 411 | 7 | 1 | 7 | 3.4 | COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | ||
CHEMBL5173623 | 196926 | 0 | None | -17 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 411 | 7 | 1 | 7 | 3.4 | COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | ||
145986700 | 173998 | 0 | None | 5 | 2 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 328 | 4 | 2 | 2 | 3.5 | CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4292109 | 173998 | 0 | None | 5 | 2 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 328 | 4 | 2 | 2 | 3.5 | CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
139451776 | 191790 | 0 | None | -3 | 2 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 277 | 6 | 1 | 5 | 1.6 | COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1 | 10.1021/acs.jmedchem.0c00627 | ||
CHEMBL4854836 | 191790 | 0 | None | -3 | 2 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 277 | 6 | 1 | 5 | 1.6 | COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1 | 10.1021/acs.jmedchem.0c00627 | ||
52918077 | 67527 | 2 | None | 1 | 2 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 233 | 4 | 1 | 4 | 1.2 | COc1ccc2ccn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | ||
CHEMBL1760945 | 67527 | 2 | None | 1 | 2 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 233 | 4 | 1 | 4 | 1.2 | COc1ccc2ccn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | ||
52953165 | 69182 | 0 | None | 87 | 2 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 389 | 7 | 1 | 3 | 5.6 | C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | ||
CHEMBL1779810 | 69182 | 0 | None | 87 | 2 | Human | 8.7 | pEC50 | = | 8.7 | Functional | ChEMBL | 389 | 7 | 1 | 3 | 5.6 | C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | ||
9818487 | 180312 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 319 | 5 | 1 | 2 | 4.2 | COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | ||
CHEMBL453138 | 180312 | 0 | None | - | 1 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 319 | 5 | 1 | 2 | 4.2 | COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | ||
10266979 | 105795 | 0 | None | 99 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 303 | 3 | 1 | 3 | 2.0 | CCNC(=O)N1CCN([C@@H]2CCc3ccc(OC)cc32)CC1 | 10.1016/s0960-894x(03)00090-8 | ||
CHEMBL280142 | 105795 | 0 | None | 99 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 303 | 3 | 1 | 3 | 2.0 | CCNC(=O)N1CCN([C@@H]2CCc3ccc(OC)cc32)CC1 | 10.1016/s0960-894x(03)00090-8 | ||
139451784 | 192174 | 0 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 317 | 7 | 1 | 5 | 2.4 | CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1 | 10.1021/acs.jmedchem.0c00627 | ||
CHEMBL4860729 | 192174 | 0 | None | 1 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 317 | 7 | 1 | 5 | 2.4 | CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1 | 10.1021/acs.jmedchem.0c00627 | ||
23642306 | 165852 | 1 | None | 17 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 287 | 6 | 2 | 3 | 2.5 | CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12 | 10.1039/C4MD00149D | ||
CHEMBL4097233 | 165852 | 1 | None | 17 | 2 | Human | 8.6 | pEC50 | = | 8.6 | Functional | ChEMBL | 287 | 6 | 2 | 3 | 2.5 | CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12 | 10.1039/C4MD00149D | ||
145993566 | 174150 | 0 | None | 1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 312 | 5 | 2 | 2 | 3.6 | CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4294790 | 174150 | 0 | None | 1 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 312 | 5 | 2 | 2 | 3.6 | CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
18360658 | 15662 | 0 | None | -10 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 518 | 13 | 2 | 5 | 5.7 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | ||
CHEMBL1097497 | 15662 | 0 | None | -10 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 518 | 13 | 2 | 5 | 5.7 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | ||
44394435 | 73701 | 0 | None | -34 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 361 | 8 | 1 | 2 | 5.2 | CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | ||
CHEMBL186586 | 73701 | 0 | None | -34 | 2 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 361 | 8 | 1 | 2 | 5.2 | CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | ||
49862664 | 21895 | 0 | None | -60 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 513 | 3 | 1 | 4 | 5.4 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CNC[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | ||
CHEMBL1209706 | 21895 | 0 | None | -60 | 2 | Human | 5.7 | pEC50 | = | 5.7 | Functional | ChEMBL | 513 | 3 | 1 | 4 | 5.4 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CNC[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | ||
162649850 | 186917 | 0 | None | 2 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 273 | 6 | 1 | 4 | 2.1 | CCCC(=O)NCCc1ncnc2ccc(OC)cc12 | 10.1016/j.ejmech.2020.112078 | ||
CHEMBL4748822 | 186917 | 0 | None | 2 | 2 | Human | 6.7 | pEC50 | = | 6.7 | Functional | ChEMBL | 273 | 6 | 1 | 4 | 2.1 | CCCC(=O)NCCc1ncnc2ccc(OC)cc12 | 10.1016/j.ejmech.2020.112078 | ||
162644724 | 186173 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 321 | 5 | 1 | 4 | 3.0 | COc1ccc2nc(-c3ccccc3)nc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2020.112078 | ||
CHEMBL4739898 | 186173 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 321 | 5 | 1 | 4 | 3.0 | COc1ccc2nc(-c3ccccc3)nc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2020.112078 | ||
162656758 | 187701 | 0 | None | 1 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 259 | 5 | 1 | 4 | 1.7 | CCC(=O)NCCc1ncnc2ccc(OC)cc12 | 10.1016/j.ejmech.2020.112078 | ||
CHEMBL4757920 | 187701 | 0 | None | 1 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 259 | 5 | 1 | 4 | 1.7 | CCC(=O)NCCc1ncnc2ccc(OC)cc12 | 10.1016/j.ejmech.2020.112078 | ||
162668689 | 189537 | 0 | None | 1 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 285 | 5 | 1 | 4 | 2.2 | COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2020.112078 | ||
CHEMBL4790145 | 189537 | 0 | None | 1 | 2 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 285 | 5 | 1 | 4 | 2.2 | COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2020.112078 | ||
1357 | 9263 | 139 | None | -1 | 5 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2019.06.008 | ||
1672 | 9263 | 139 | None | -1 | 5 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2019.06.008 | ||
224 | 9263 | 139 | None | -1 | 5 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2019.06.008 | ||
896 | 9263 | 139 | None | -1 | 5 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2019.06.008 | ||
CHEMBL45 | 9263 | 139 | None | -1 | 5 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2019.06.008 | ||
DB01065 | 9263 | 139 | None | -1 | 5 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2019.06.008 | ||
23658143 | 163156 | 1 | None | 41 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 291 | 6 | 2 | 3 | 2.0 | COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1 | 10.1039/C4MD00149D | ||
CHEMBL4066279 | 163156 | 1 | None | 41 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 291 | 6 | 2 | 3 | 2.0 | COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1 | 10.1039/C4MD00149D | ||
10163052 | 15293 | 0 | None | -10 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 483 | 12 | 2 | 4 | 5.9 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12 | 10.1016/j.bmc.2010.04.008 | ||
CHEMBL1094212 | 15293 | 0 | None | -10 | 2 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 483 | 12 | 2 | 4 | 5.9 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12 | 10.1016/j.bmc.2010.04.008 | ||
122178509 | 128106 | 0 | None | 9 | 2 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 259 | 4 | 2 | 4 | 1.6 | COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | ||
CHEMBL3580919 | 128106 | 0 | None | 9 | 2 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 259 | 4 | 2 | 4 | 1.6 | COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | ||
86273222 | 128101 | 0 | None | 2 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 243 | 3 | 1 | 4 | 2.5 | COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1 | 10.1021/acs.jmedchem.5b00245 | ||
CHEMBL3580913 | 128101 | 0 | None | 2 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 243 | 3 | 1 | 4 | 2.5 | COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1 | 10.1021/acs.jmedchem.5b00245 | ||
49862738 | 21912 | 0 | None | -36 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 555 | 4 | 0 | 4 | 6.5 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)C)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | ||
CHEMBL1209790 | 21912 | 0 | None | -36 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 555 | 4 | 0 | 4 | 6.5 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)C)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | ||
145982333 | 173336 | 0 | None | 2 | 2 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 284 | 3 | 2 | 2 | 2.8 | CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4279639 | 173336 | 0 | None | 2 | 2 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 284 | 3 | 2 | 2 | 2.8 | CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
145979689 | 173402 | 0 | None | 1 | 2 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 314 | 3 | 2 | 2 | 3.1 | CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4280791 | 173402 | 0 | None | 1 | 2 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 314 | 3 | 2 | 2 | 3.1 | CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
145987794 | 173899 | 0 | None | 6 | 2 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 298 | 4 | 2 | 2 | 3.2 | CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4290302 | 173899 | 0 | None | 6 | 2 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 298 | 4 | 2 | 2 | 3.2 | CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
86273226 | 128096 | 0 | None | 12 | 2 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 256 | 5 | 2 | 2 | 1.9 | C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12 | 10.1021/acs.jmedchem.5b00245 | ||
CHEMBL3580908 | 128096 | 0 | None | 12 | 2 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 256 | 5 | 2 | 2 | 1.9 | C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12 | 10.1021/acs.jmedchem.5b00245 | ||
137645887 | 164719 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 294 | 4 | 1 | 2 | 3.0 | CC(=O)NCC1Cc2ccccc2N(Cc2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | ||
CHEMBL4084568 | 164719 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 294 | 4 | 1 | 2 | 3.0 | CC(=O)NCC1Cc2ccccc2N(Cc2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | ||
127026426 | 144578 | 0 | None | 1 | 2 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 309 | 5 | 1 | 3 | 3.7 | COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
CHEMBL3759606 | 144578 | 0 | None | 1 | 2 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 309 | 5 | 1 | 3 | 3.7 | COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
127025783 | 144516 | 0 | None | 8 | 2 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 287 | 4 | 1 | 3 | 3.2 | COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
CHEMBL3759160 | 144516 | 0 | None | 8 | 2 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 287 | 4 | 1 | 3 | 3.2 | COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
162647716 | 186666 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 259 | 5 | 1 | 4 | 1.7 | CCC(=O)NCCc1nncc2ccc(OC)cc12 | 10.1016/j.ejmech.2020.112078 | ||
CHEMBL4745789 | 186666 | 0 | None | - | 1 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 259 | 5 | 1 | 4 | 1.7 | CCC(=O)NCCc1nncc2ccc(OC)cc12 | 10.1016/j.ejmech.2020.112078 | ||
168296374 | 199297 | 0 | None | -9 | 2 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 505 | 9 | 1 | 8 | 4.5 | CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1 | 10.1021/acs.jmedchem.2c00717 | ||
CHEMBL5209359 | 199297 | 0 | None | -9 | 2 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 505 | 9 | 1 | 8 | 4.5 | CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1 | 10.1021/acs.jmedchem.2c00717 | ||
49862665 | 21896 | 0 | None | -128 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 585 | 5 | 1 | 5 | 5.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)CO)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | ||
CHEMBL1209707 | 21896 | 0 | None | -128 | 2 | Human | 6.5 | pEC50 | = | 6.5 | Functional | ChEMBL | 585 | 5 | 1 | 5 | 5.9 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C(C)(C)CO)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | ||
19703063 | 35688 | 1 | None | -1 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 233 | 4 | 2 | 3 | 1.2 | COc1c[nH]c2ncc(CCNC(C)=O)c-2c1 | 10.1016/j.bmcl.2011.02.097 | ||
CHEMBL137969 | 35688 | 1 | None | -1 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 233 | 4 | 2 | 3 | 1.2 | COc1c[nH]c2ncc(CCNC(C)=O)c-2c1 | 10.1016/j.bmcl.2011.02.097 | ||
145992795 | 173570 | 0 | None | 25 | 2 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 342 | 5 | 2 | 2 | 3.9 | CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4284223 | 173570 | 0 | None | 25 | 2 | Human | 8.4 | pEC50 | = | 8.4 | Functional | ChEMBL | 342 | 5 | 2 | 2 | 3.9 | CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
9937825 | 15640 | 0 | None | -2 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 564 | 17 | 2 | 4 | 6.7 | C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | ||
CHEMBL1097315 | 15640 | 0 | None | -2 | 2 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 564 | 17 | 2 | 4 | 6.7 | C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | ||
1355 | 10211 | 5 | None | -5 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1016/j.bmc.2010.04.008 | ||
9806449 | 10211 | 5 | None | -5 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1016/j.bmc.2010.04.008 | ||
CHEMBL14453 | 10211 | 5 | None | -5 | 2 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1016/j.bmc.2010.04.008 | ||
162658247 | 187797 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 245 | 4 | 1 | 4 | 1.3 | COc1ccc2cnnc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2020.112078 | ||
CHEMBL4759137 | 187797 | 0 | None | - | 1 | Human | 6.4 | pEC50 | = | 6.4 | Functional | ChEMBL | 245 | 4 | 1 | 4 | 1.3 | COc1ccc2cnnc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2020.112078 | ||
122178508 | 128104 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 243 | 4 | 1 | 4 | 2.3 | COc1ccc2[nH]cc(CCc3nnco3)c2c1 | 10.1021/acs.jmedchem.5b00245 | ||
CHEMBL3580917 | 128104 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 243 | 4 | 1 | 4 | 2.3 | COc1ccc2[nH]cc(CCc3nnco3)c2c1 | 10.1021/acs.jmedchem.5b00245 | ||
49862739 | 21913 | 0 | None | -23 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 583 | 6 | 0 | 4 | 7.3 | CCC(CC)N1C[C@@H](C(=O)N2CCC3(CC2)O[C@H](C(C)(C)C#N)c2cc(C)c(Cl)cc23)[C@H](c2ccc(F)cc2F)C1 | 10.1016/j.bmcl.2010.06.068 | ||
CHEMBL1209791 | 21913 | 0 | None | -23 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 583 | 6 | 0 | 4 | 7.3 | CCC(CC)N1C[C@@H](C(=O)N2CCC3(CC2)O[C@H](C(C)(C)C#N)c2cc(C)c(Cl)cc23)[C@H](c2ccc(F)cc2F)C1 | 10.1016/j.bmcl.2010.06.068 | ||
9064 | 111996 | 94 | None | -2 | 4 | Human | 4.3 | pEC50 | = | 4.3 | Functional | ChEMBL | 290 | 1 | 5 | 6 | 1.5 | Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2 | 10.1016/j.ejmech.2020.112960 | ||
CHEMBL311498 | 111996 | 94 | None | -2 | 4 | Human | 4.3 | pEC50 | = | 4.3 | Functional | ChEMBL | 290 | 1 | 5 | 6 | 1.5 | Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2 | 10.1016/j.ejmech.2020.112960 | ||
145991966 | 173615 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 285 | 3 | 1 | 3 | 3.2 | COC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4285145 | 173615 | 0 | None | - | 1 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 285 | 3 | 1 | 3 | 3.2 | COC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
145986330 | 173836 | 0 | None | 3 | 2 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 286 | 3 | 2 | 2 | 2.7 | COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4289115 | 173836 | 0 | None | 3 | 2 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 286 | 3 | 2 | 2 | 2.7 | COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3 | 10.1016/j.ejmech.2017.10.025 | ||
122178509 | 128106 | 0 | None | 9 | 2 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 259 | 4 | 2 | 4 | 1.6 | COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | ||
CHEMBL3580919 | 128106 | 0 | None | 9 | 2 | Human | 8.3 | pEC50 | = | 8.3 | Functional | ChEMBL | 259 | 4 | 2 | 4 | 1.6 | COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | ||
127025781 | 144602 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 309 | 5 | 1 | 3 | 3.7 | COc1ccc2ccc3oc(CCNC(=O)C4CC4)cc3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
CHEMBL3759859 | 144602 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 309 | 5 | 1 | 3 | 3.7 | COc1ccc2ccc3oc(CCNC(=O)C4CC4)cc3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
145983175 | 173210 | 0 | None | 1 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 314 | 4 | 2 | 2 | 3.4 | CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4277390 | 173210 | 0 | None | 1 | 2 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 314 | 4 | 2 | 2 | 3.4 | CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
86273470 | 128100 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 256 | 4 | 1 | 3 | 3.3 | COc1ccc2[nH]cc(CCc3ncc(C)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | ||
CHEMBL3580912 | 128100 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 256 | 4 | 1 | 3 | 3.3 | COc1ccc2[nH]cc(CCc3ncc(C)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | ||
162649247 | 186854 | 0 | None | -1 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 351 | 6 | 1 | 5 | 3.0 | COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1 | 10.1016/j.ejmech.2020.112078 | ||
CHEMBL4747996 | 186854 | 0 | None | -1 | 2 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 351 | 6 | 1 | 5 | 3.0 | COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1 | 10.1016/j.ejmech.2020.112078 | ||
145979282 | 173454 | 0 | None | 1 | 2 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 300 | 3 | 2 | 2 | 3.0 | CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
CHEMBL4281915 | 173454 | 0 | None | 1 | 2 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 300 | 3 | 2 | 2 | 3.0 | CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | ||
127025786 | 144627 | 0 | None | 12 | 2 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 312 | 5 | 2 | 3 | 3.5 | CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12 | 10.1016/j.ejmech.2015.12.047 | ||
CHEMBL3760044 | 144627 | 0 | None | 12 | 2 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 312 | 5 | 2 | 3 | 3.5 | CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12 | 10.1016/j.ejmech.2015.12.047 | ||
49862740 | 21914 | 0 | None | -10 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 585 | 6 | 0 | 5 | 6.1 | COCC(C)N1C[C@@H](C(=O)N2CCC3(CC2)O[C@H](C(C)(C)C#N)c2cc(C)c(Cl)cc23)[C@H](c2ccc(F)cc2F)C1 | 10.1016/j.bmcl.2010.06.068 | ||
CHEMBL1209792 | 21914 | 0 | None | -10 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | ChEMBL | 585 | 6 | 0 | 5 | 6.1 | COCC(C)N1C[C@@H](C(=O)N2CCC3(CC2)O[C@H](C(C)(C)C#N)c2cc(C)c(Cl)cc23)[C@H](c2ccc(F)cc2F)C1 | 10.1016/j.bmcl.2010.06.068 | ||
137636079 | 163006 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 232 | 3 | 1 | 2 | 1.8 | CCN1CC(CNC(C)=O)Cc2ccccc21 | 10.1021/acs.jmedchem.8b00359 | ||
CHEMBL4064626 | 163006 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 232 | 3 | 1 | 2 | 1.8 | CCN1CC(CNC(C)=O)Cc2ccccc21 | 10.1021/acs.jmedchem.8b00359 | ||
11351216 | 69178 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 441 | 6 | 1 | 3 | 5.4 | O=C(CBr)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | ||
CHEMBL1779807 | 69178 | 0 | None | - | 1 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 441 | 6 | 1 | 3 | 5.4 | O=C(CBr)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | ||
23658145 | 164242 | 1 | None | 52 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 287 | 6 | 2 | 3 | 2.5 | CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12 | 10.1039/C4MD00149D | ||
CHEMBL4079214 | 164242 | 1 | None | 52 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 287 | 6 | 2 | 3 | 2.5 | CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12 | 10.1039/C4MD00149D | ||
4018512 | 49994 | 42 | None | 2 | 2 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 308 | 5 | 2 | 2 | 3.5 | COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2c1 | 10.1039/d2md00156j | ||
CHEMBL15060 | 49994 | 42 | None | 2 | 2 | Human | 5.2 | pEC50 | = | 5.2 | Functional | ChEMBL | 308 | 5 | 2 | 2 | 3.5 | COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2c1 | 10.1039/d2md00156j | ||
122178507 | 128102 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 243 | 3 | 1 | 4 | 2.5 | COc1ccc2[nH]cc(Cc3nnc(C)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | ||
CHEMBL3580915 | 128102 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 243 | 3 | 1 | 4 | 2.5 | COc1ccc2[nH]cc(Cc3nnc(C)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | ||
49862737 | 21911 | 0 | None | -10 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 611 | 5 | 0 | 5 | 6.5 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(CC4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | ||
CHEMBL1209789 | 21911 | 0 | None | -10 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 611 | 5 | 0 | 5 | 6.5 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(CC4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | ||
127025782 | 144509 | 0 | None | -1 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 297 | 4 | 1 | 3 | 3.9 | COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
CHEMBL3759054 | 144509 | 0 | None | -1 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 297 | 4 | 1 | 3 | 3.9 | COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
127026425 | 144598 | 0 | None | -8 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 295 | 4 | 1 | 3 | 3.6 | COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
CHEMBL3759816 | 144598 | 0 | None | -8 | 2 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 295 | 4 | 1 | 3 | 3.6 | COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | ||
137656715 | 166326 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 308 | 5 | 1 | 2 | 3.0 | CC(=O)NCC1Cc2ccccc2N(CCc2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | ||
CHEMBL4102517 | 166326 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 308 | 5 | 1 | 2 | 3.0 | CC(=O)NCC1Cc2ccccc2N(CCc2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | ||
86273227 | 128095 | 0 | None | 3 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 242 | 4 | 2 | 2 | 1.5 | C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12 | 10.1021/acs.jmedchem.5b00245 | ||
CHEMBL3580907 | 128095 | 0 | None | 3 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 242 | 4 | 2 | 2 | 1.5 | C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12 | 10.1021/acs.jmedchem.5b00245 | ||
86079062 | 187511 | 0 | None | 3 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 245 | 4 | 1 | 4 | 1.3 | COc1ccc2ncnc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2020.112078 | ||
CHEMBL4755860 | 187511 | 0 | None | 3 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 245 | 4 | 1 | 4 | 1.3 | COc1ccc2ncnc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2020.112078 | ||
46888522 | 15417 | 0 | None | -3 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 513 | 12 | 1 | 5 | 6.2 | COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1 | 10.1016/j.bmc.2010.04.008 | ||
CHEMBL1095197 | 15417 | 0 | None | -3 | 2 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 513 | 12 | 1 | 5 | 6.2 | COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1 | 10.1016/j.bmc.2010.04.008 | ||
81689735 | 128103 | 0 | None | -1 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 257 | 4 | 1 | 4 | 2.7 | COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | ||
CHEMBL3580916 | 128103 | 0 | None | -1 | 2 | Human | 6.1 | pEC50 | = | 6.1 | Functional | ChEMBL | 257 | 4 | 1 | 4 | 2.7 | COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | ||
198 | 7101 | 126 | None | 3 | 4 | Human | 4.1 | pEC50 | = | 4.1 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1039/d2md00156j | ||
82148 | 7101 | 126 | None | 3 | 4 | Human | 4.1 | pEC50 | = | 4.1 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1039/d2md00156j | ||
99 | 7101 | 126 | None | 3 | 4 | Human | 4.1 | pEC50 | = | 4.1 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1039/d2md00156j | ||
CHEMBL10878 | 7101 | 126 | None | 3 | 4 | Human | 4.1 | pEC50 | = | 4.1 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1039/d2md00156j | ||
DB06594 | 7101 | 126 | None | 3 | 4 | Human | 4.1 | pEC50 | = | 4.1 | Functional | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1039/d2md00156j | ||
162661094 | 188222 | 3 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 273 | 6 | 1 | 4 | 2.1 | CCCC(=O)NCCc1nncc2ccc(OC)cc12 | 10.1016/j.ejmech.2020.112078 | ||
CHEMBL4764211 | 188222 | 3 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 273 | 6 | 1 | 4 | 2.1 | CCCC(=O)NCCc1nncc2ccc(OC)cc12 | 10.1016/j.ejmech.2020.112078 | ||
164946945 | 197008 | 1 | None | 3 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 427 | 9 | 1 | 7 | 3.3 | COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | ||
CHEMBL5174929 | 197008 | 1 | None | 3 | 2 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 427 | 9 | 1 | 7 | 3.3 | COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | ||
44396074 | 73927 | 2 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 339 | 5 | 0 | 3 | 3.8 | COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(C)=O)CC2 | 10.1021/jm401343c | ||
CHEMBL187593 | 73927 | 2 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 339 | 5 | 0 | 3 | 3.8 | COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(C)=O)CC2 | 10.1021/jm401343c | ||
9909783 | 73910 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 415 | 6 | 0 | 3 | 5.4 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 | 10.1021/jm401343c | ||
CHEMBL187525 | 73910 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 415 | 6 | 0 | 3 | 5.4 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 | 10.1021/jm401343c | ||
16094585 | 89665 | 0 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 321 | 6 | 1 | 2 | 4.0 | COc1cccc(/C(=C/CNC(=O)C2CCC2)c2ccccc2)c1 | 10.1021/jm060850a | ||
CHEMBL218065 | 89665 | 0 | None | - | 0 | Human | 9.4 | pKd | = | 9.4 | Functional | ChEMBL | 321 | 6 | 1 | 2 | 4.0 | COc1cccc(/C(=C/CNC(=O)C2CCC2)c2ccccc2)c1 | 10.1021/jm060850a | ||
90655902 | 117644 | 0 | None | - | 0 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 330 | 5 | 2 | 4 | 2.5 | CCOC(=O)c1[nH]c2ccc(OC)c3c2c1[C@@H](CNC(C)=O)CC3 | 10.1021/jm401343c | ||
CHEMBL3260982 | 117644 | 0 | None | - | 0 | Human | 9.5 | pKi | = | 9.5 | Functional | ChEMBL | 330 | 5 | 2 | 4 | 2.5 | CCOC(=O)c1[nH]c2ccc(OC)c3c2c1[C@@H](CNC(C)=O)CC3 | 10.1021/jm401343c | ||
52918077 | 67527 | 2 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 233 | 4 | 1 | 4 | 1.2 | COc1ccc2ccn(CCNC(C)=O)c2n1 | 10.1021/jm401343c | ||
CHEMBL1760945 | 67527 | 2 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Functional | ChEMBL | 233 | 4 | 1 | 4 | 1.2 | COc1ccc2ccn(CCNC(C)=O)c2n1 | 10.1021/jm401343c | ||
11185529 | 10686 | 5 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 295 | 3 | 1 | 2 | 3.1 | COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 | 10.1021/jm401343c | ||
7772 | 10686 | 5 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 295 | 3 | 1 | 2 | 3.1 | COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 | 10.1021/jm401343c | ||
CHEMBL189449 | 10686 | 5 | None | - | 0 | Human | 8.9 | pKi | = | 8.9 | Functional | ChEMBL | 295 | 3 | 1 | 2 | 3.1 | COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 | 10.1021/jm401343c | ||
24763223 | 7004 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 340 | 10 | 1 | 3 | 3.7 | CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C | 10.1021/jm401343c | ||
8289 | 7004 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 340 | 10 | 1 | 3 | 3.7 | CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C | 10.1021/jm401343c | ||
CHEMBL3260987 | 7004 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7.0 | Functional | ChEMBL | 340 | 10 | 1 | 3 | 3.7 | CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C | 10.1021/jm401343c | ||
1357 | 9263 | 139 | None | -1 | 5 | Human | 8.0 | pEC50 | = | 8.0 | Functional | Drug Central | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | ||
1672 | 9263 | 139 | None | -1 | 5 | Human | 8.0 | pEC50 | = | 8.0 | Functional | Drug Central | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | ||
224 | 9263 | 139 | None | -1 | 5 | Human | 8.0 | pEC50 | = | 8.0 | Functional | Drug Central | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | ||
896 | 9263 | 139 | None | -1 | 5 | Human | 8.0 | pEC50 | = | 8.0 | Functional | Drug Central | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | ||
CHEMBL45 | 9263 | 139 | None | -1 | 5 | Human | 8.0 | pEC50 | = | 8.0 | Functional | Drug Central | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | ||
DB01065 | 9263 | 139 | None | -1 | 5 | Human | 8.0 | pEC50 | = | 8.0 | Functional | Drug Central | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | ||
10666 | 10692 | 0 | None | -21 | 2 | Human | 6.0 | pEC50 | = | 6.0 | Functional | Guide to Pharmacology | 362 | 4 | 2 | 3 | 4.5 | Clc1ccc(c(c1)Br)CNc1cccc(c1)c1nnc[nH]1 | 32040955 | ||
138993662 | 10692 | 0 | None | -21 | 2 | Human | 6.0 | pEC50 | = | 6.0 | Functional | Guide to Pharmacology | 362 | 4 | 2 | 3 | 4.5 | Clc1ccc(c(c1)Br)CNc1cccc(c1)c1nnc[nH]1 | 32040955 | ||
10665 | 10690 | 0 | None | -50 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | Guide to Pharmacology | 292 | 5 | 2 | 3 | 4.2 | CC(c1ccc(cc1)CNc1cccc(c1)c1[nH]cnn1)C | 32040955 | ||
137977202 | 10690 | 0 | None | -50 | 2 | Human | 6.2 | pEC50 | = | 6.2 | Functional | Guide to Pharmacology | 292 | 5 | 2 | 3 | 4.2 | CC(c1ccc(cc1)CNc1cccc(c1)c1[nH]cnn1)C | 32040955 | ||
103828029 | 10691 | 0 | None | 20 | 2 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Guide to Pharmacology | 292 | 4 | 1 | 3 | 3.5 | COc1ccc(c(c1)CNc1cccnc1)Br | 32040955 | ||
10667 | 10691 | 0 | None | 20 | 2 | Human | 8.2 | pEC50 | = | 8.2 | Functional | Guide to Pharmacology | 292 | 4 | 1 | 3 | 3.5 | COc1ccc(c(c1)CNc1cccnc1)Br | 32040955 |
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
10440 | 9458 | 20 | None | -3 | 3 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 417 | 7 | 3 | 7 | 4.2 | OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F | 10.1021/acs.jmedchem.9b00869 | |||
139030523 | 9458 | 20 | None | -3 | 3 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 417 | 7 | 3 | 7 | 4.2 | OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F | 10.1021/acs.jmedchem.9b00869 | |||
CHEMBL4449712 | 9458 | 20 | None | -3 | 3 | Human | 6.3 | pEC50 | = | 6.3 | Binding | ChEMBL | 417 | 7 | 3 | 7 | 4.2 | OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F | 10.1021/acs.jmedchem.9b00869 | |||
23634404 | 132628 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 272 | 4 | 1 | 3 | 3.1 | CCC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21 | nan | |||
CHEMBL3648359 | 132628 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 272 | 4 | 1 | 3 | 3.1 | CCC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21 | nan | |||
57781211 | 132630 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 376 | 8 | 1 | 3 | 4.9 | CC(=O)NCCC1CCc2ccc3nc(CCCCc4ccccc4)oc3c21 | nan | |||
CHEMBL3648361 | 132630 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 376 | 8 | 1 | 3 | 4.9 | CC(=O)NCCC1CCc2ccc3nc(CCCCc4ccccc4)oc3c21 | nan | |||
23725569 | 132632 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 274 | 3 | 1 | 3 | 3.2 | CC(=O)NCC[C@@H]1CCc2ccc3nc(C)sc3c21 | nan | |||
CHEMBL3648363 | 132632 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 274 | 3 | 1 | 3 | 3.2 | CC(=O)NCC[C@@H]1CCc2ccc3nc(C)sc3c21 | nan | |||
57781216 | 132625 | 0 | None | -2 | 2 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 258 | 3 | 1 | 3 | 2.7 | CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21 | nan | |||
CHEMBL3648356 | 132625 | 0 | None | -2 | 2 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 258 | 3 | 1 | 3 | 2.7 | CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21 | nan | |||
57781258 | 132638 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 312 | 3 | 1 | 3 | 3.2 | Cc1nc2ccc3c(c2o1)C(CCNC(=O)C(F)(F)F)CC3 | nan | |||
CHEMBL3648369 | 132638 | 0 | None | - | 0 | Human | 9.9 | pIC50 | = | 9.9 | Binding | ChEMBL | 312 | 3 | 1 | 3 | 3.2 | Cc1nc2ccc3c(c2o1)C(CCNC(=O)C(F)(F)F)CC3 | nan | |||
57781244 | 167612 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 270 | 3 | 1 | 3 | 3.0 | CCC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21 | nan | |||
CHEMBL4114700 | 167612 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 270 | 3 | 1 | 3 | 3.0 | CCC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21 | nan | |||
57781280 | 167743 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 272 | 2 | 1 | 3 | 3.1 | CC(=O)NC/C=C1\CCc2ccc3nc(C)sc3c21 | nan | |||
CHEMBL4115681 | 167743 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 272 | 2 | 1 | 3 | 3.1 | CC(=O)NC/C=C1\CCc2ccc3nc(C)sc3c21 | nan | |||
23725512 | 132622 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 256 | 3 | 1 | 3 | 2.6 | CC(=O)NCCC1=CCc2ccc3nc(C)oc3c21 | nan | |||
CHEMBL3648350 | 132622 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 256 | 3 | 1 | 3 | 2.6 | CC(=O)NCCC1=CCc2ccc3nc(C)oc3c21 | nan | |||
23725514 | 132627 | 0 | None | -1 | 2 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 272 | 4 | 1 | 3 | 3.1 | CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21 | nan | |||
CHEMBL3648358 | 132627 | 0 | None | -1 | 2 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 272 | 4 | 1 | 3 | 3.1 | CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21 | nan | |||
23725567 | 132631 | 0 | None | -2 | 2 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 274 | 3 | 1 | 3 | 3.2 | CC(=O)NCCC1CCc2ccc3nc(C)sc3c21 | nan | |||
CHEMBL3648362 | 132631 | 0 | None | -2 | 2 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 274 | 3 | 1 | 3 | 3.2 | CC(=O)NCCC1CCc2ccc3nc(C)sc3c21 | nan | |||
23725612 | 132636 | 0 | None | 2 | 2 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 274 | 4 | 1 | 4 | 2.4 | COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3 | nan | |||
CHEMBL3648367 | 132636 | 0 | None | 2 | 2 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 274 | 4 | 1 | 4 | 2.4 | COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3 | nan | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/s0960-894x(03)00090-8 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/s0960-894x(03)00090-8 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/s0960-894x(03)00090-8 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/s0960-894x(03)00090-8 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/s0960-894x(03)00090-8 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/s0960-894x(03)00090-8 | |||
57781227 | 132623 | 0 | None | 6 | 2 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 244 | 3 | 1 | 3 | 2.4 | CC(=O)NCCC1CCc2ccc3ncoc3c21 | nan | |||
CHEMBL3648354 | 132623 | 0 | None | 6 | 2 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 244 | 3 | 1 | 3 | 2.4 | CC(=O)NCCC1CCc2ccc3ncoc3c21 | nan | |||
23725565 | 132624 | 0 | None | -1 | 2 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 258 | 3 | 1 | 3 | 2.7 | CC(=O)NCCC1CCc2ccc3nc(C)oc3c21 | nan | |||
CHEMBL3648355 | 132624 | 0 | None | -1 | 2 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 258 | 3 | 1 | 3 | 2.7 | CC(=O)NCCC1CCc2ccc3nc(C)oc3c21 | nan | |||
57781268 | 167609 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 256 | 2 | 1 | 3 | 2.6 | CC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21 | nan | |||
CHEMBL4114658 | 167609 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 256 | 2 | 1 | 3 | 2.6 | CC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21 | nan | |||
23725515 | 132634 | 0 | None | 1 | 2 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 272 | 4 | 1 | 3 | 2.9 | CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3 | nan | |||
CHEMBL3648365 | 132634 | 0 | None | 1 | 2 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 272 | 4 | 1 | 3 | 2.9 | CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3 | nan | |||
57781262 | 167615 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 374 | 7 | 1 | 3 | 4.9 | CC(=O)NC/C=C1\CCc2ccc3nc(CCCCc4ccccc4)oc3c21 | nan | |||
CHEMBL4114715 | 167615 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 374 | 7 | 1 | 3 | 4.9 | CC(=O)NC/C=C1\CCc2ccc3nc(CCCCc4ccccc4)oc3c21 | nan | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2011.02.010 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2011.02.010 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2011.02.010 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2011.02.010 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2011.02.010 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2011.02.010 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.03.036 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.03.036 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.03.036 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.03.036 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.03.036 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.03.036 | |||
10059864 | 116600 | 5 | None | -2 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 233 | 4 | 1 | 3 | 2.1 | COc1ccc2occ(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.03.036 | |||
CHEMBL323332 | 116600 | 5 | None | -2 | 2 | Human | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | 233 | 4 | 1 | 3 | 2.1 | COc1ccc2occ(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.03.036 | |||
57781246 | 132635 | 0 | None | 2 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 284 | 4 | 1 | 3 | 3.3 | CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21 | nan | |||
CHEMBL3648366 | 132635 | 0 | None | 2 | 2 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 284 | 4 | 1 | 3 | 3.3 | CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21 | nan | |||
57781261 | 132637 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 284 | 4 | 1 | 3 | 3.1 | Cc1nc2ccc3c(c2o1)C(CCNC(=O)C1CC1)CC3 | nan | |||
CHEMBL3648368 | 132637 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 284 | 4 | 1 | 3 | 3.1 | Cc1nc2ccc3c(c2o1)C(CCNC(=O)C1CC1)CC3 | nan | |||
9859969 | 181802 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 259 | 4 | 1 | 2 | 3.2 | CSc1ccc2cccc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2011.02.010 | |||
CHEMBL456727 | 181802 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 259 | 4 | 1 | 2 | 3.2 | CSc1ccc2cccc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2011.02.010 | |||
22375372 | 74032 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 302 | 3 | 0 | 3 | 2.5 | COc1ccc2c(c1)C(N1CCN(C(=O)C(C)C)CC1)CC2 | 10.1016/s0960-894x(03)00090-8 | |||
CHEMBL18808 | 74032 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 302 | 3 | 0 | 3 | 2.5 | COc1ccc2c(c1)C(N1CCN(C(=O)C(C)C)CC1)CC2 | 10.1016/s0960-894x(03)00090-8 | |||
44272486 | 76603 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 302 | 3 | 0 | 3 | 2.5 | COc1ccc2c(c1)[C@H](N1CCN(C(=O)C(C)C)CC1)CC2 | 10.1016/s0960-894x(03)00090-8 | |||
CHEMBL19374 | 76603 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 302 | 3 | 0 | 3 | 2.5 | COc1ccc2c(c1)[C@H](N1CCN(C(=O)C(C)C)CC1)CC2 | 10.1016/s0960-894x(03)00090-8 | |||
44272591 | 78480 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 300 | 3 | 0 | 3 | 2.2 | COc1ccc2c(c1)[C@H](N1CCN(C(=O)C3CC3)CC1)CC2 | 10.1016/s0960-894x(03)00090-8 | |||
CHEMBL19653 | 78480 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 300 | 3 | 0 | 3 | 2.2 | COc1ccc2c(c1)[C@H](N1CCN(C(=O)C3CC3)CC1)CC2 | 10.1016/s0960-894x(03)00090-8 | |||
10266979 | 105795 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 303 | 3 | 1 | 3 | 2.0 | CCNC(=O)N1CCN([C@@H]2CCc3ccc(OC)cc32)CC1 | 10.1016/s0960-894x(03)00090-8 | |||
CHEMBL280142 | 105795 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 303 | 3 | 1 | 3 | 2.0 | CCNC(=O)N1CCN([C@@H]2CCc3ccc(OC)cc32)CC1 | 10.1016/s0960-894x(03)00090-8 | |||
11213541 | 134282 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 469 | 6 | 0 | 3 | 5.9 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C(F)(F)F)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL366115 | 134282 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7 | Binding | ChEMBL | 469 | 6 | 0 | 3 | 5.9 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C(F)(F)F)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
10198772 | 199862 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 246 | 4 | 2 | 3 | 1.2 | CC(=O)NCCc1coc2ccc(C(N)=O)cc12 | 10.1016/j.bmc.2008.03.036 | |||
CHEMBL522528 | 199862 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 246 | 4 | 2 | 3 | 1.2 | CC(=O)NCCc1coc2ccc(C(N)=O)cc12 | 10.1016/j.bmc.2008.03.036 | |||
44396113 | 73616 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 469 | 6 | 0 | 3 | 6.1 | COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(=O)c1ccc(C(F)(F)F)cc1)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL186167 | 73616 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 469 | 6 | 0 | 3 | 6.1 | COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(=O)c1ccc(C(F)(F)F)cc1)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
44272252 | 105498 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 316 | 5 | 0 | 3 | 3.0 | CCCCC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1 | 10.1016/s0960-894x(03)00090-8 | |||
CHEMBL277828 | 105498 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 316 | 5 | 0 | 3 | 3.0 | CCCCC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1 | 10.1016/s0960-894x(03)00090-8 | |||
11784859 | 130073 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 477 | 7 | 0 | 3 | 6.7 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)c1ccccc1)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL361458 | 130073 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 477 | 7 | 0 | 3 | 6.7 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)c1ccccc1)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
44396149 | 73773 | 4 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 355 | 4 | 0 | 1 | 5.4 | CC(=O)N1CCc2ccccc2C1CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL186915 | 73773 | 4 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 355 | 4 | 0 | 1 | 5.4 | CC(=O)N1CCc2ccccc2C1CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
44395896 | 73638 | 3 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 373 | 4 | 0 | 1 | 5.5 | CC(=O)N1CCc2cc(F)ccc2C1CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL186251 | 73638 | 3 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 373 | 4 | 0 | 1 | 5.5 | CC(=O)N1CCc2cc(F)ccc2C1CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
46919520 | 21910 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 597 | 4 | 0 | 5 | 6.3 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | |||
CHEMBL1209788 | 21910 | 0 | None | - | 0 | Human | 5.8 | pIC50 | = | 5.8 | Binding | ChEMBL | 597 | 4 | 0 | 5 | 6.3 | Cc1cc2c(cc1Cl)C1(CCN(C(=O)[C@@H]3CN(C4CCOCC4)C[C@H]3c3ccc(F)cc3F)CC1)O[C@@H]2C(C)(C)C#N | 10.1016/j.bmcl.2010.06.068 | |||
44396148 | 73763 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 340 | 5 | 1 | 3 | 3.3 | COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(N)=O)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL186866 | 73763 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 340 | 5 | 1 | 3 | 3.3 | COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(N)=O)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
22375370 | 74788 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 302 | 4 | 0 | 3 | 2.6 | CCCC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1 | 10.1016/s0960-894x(03)00090-8 | |||
CHEMBL19123 | 74788 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 302 | 4 | 0 | 3 | 2.6 | CCCC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1 | 10.1016/s0960-894x(03)00090-8 | |||
18175057 | 194174 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 314 | 4 | 2 | 3 | 2.6 | CC(=O)NCCc1coc2ccc(NC(=O)C(F)(F)F)cc12 | 10.1016/j.bmc.2008.03.036 | |||
CHEMBL493607 | 194174 | 0 | None | - | 0 | Human | 5.7 | pIC50 | = | 5.7 | Binding | ChEMBL | 314 | 4 | 2 | 3 | 2.6 | CC(=O)NCCc1coc2ccc(NC(=O)C(F)(F)F)cc12 | 10.1016/j.bmc.2008.03.036 | |||
11430378 | 174998 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 431 | 6 | 0 | 4 | 5.6 | COC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL433573 | 174998 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 431 | 6 | 0 | 4 | 5.6 | COC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
44396058 | 73823 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 407 | 6 | 0 | 3 | 5.3 | COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(=O)C1CCCCC1)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL187148 | 73823 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 407 | 6 | 0 | 3 | 5.3 | COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(=O)C1CCCCC1)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
44272451 | 74425 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 294 | 4 | 0 | 3 | 2.1 | COc1ccc(F)c(CN2CCN(C(=O)C(C)C)CC2)c1 | 10.1016/s0960-894x(03)00090-8 | |||
CHEMBL19061 | 74425 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 294 | 4 | 0 | 3 | 2.1 | COc1ccc(F)c(CN2CCN(C(=O)C(C)C)CC2)c1 | 10.1016/s0960-894x(03)00090-8 | |||
11178762 | 73780 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 463 | 5 | 0 | 2 | 6.1 | COc1cc2c(cc1Br)CCN(C(C)=O)C2CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL186941 | 73780 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 463 | 5 | 0 | 2 | 6.1 | COc1cc2c(cc1Br)CCN(C(C)=O)C2CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
44396057 | 133870 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 379 | 6 | 0 | 3 | 4.6 | COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(=O)C1CCC1)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL365648 | 133870 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 379 | 6 | 0 | 3 | 4.6 | COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(=O)C1CCC1)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
44396034 | 134081 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 455 | 7 | 0 | 3 | 6.2 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C1CCC1)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL365899 | 134081 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 455 | 7 | 0 | 3 | 6.2 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C1CCC1)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
17957000 | 68179 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 286 | 4 | 2 | 3 | 2.7 | COC(=O)Nc1ccc2cccc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2011.02.010 | |||
CHEMBL1770214 | 68179 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 286 | 4 | 2 | 3 | 2.7 | COC(=O)Nc1ccc2cccc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2011.02.010 | |||
44272539 | 73898 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 292 | 4 | 0 | 3 | 1.9 | COc1ccc(F)c(CN2CCN(C(=O)C3CC3)CC2)c1 | 10.1016/s0960-894x(03)00090-8 | |||
CHEMBL18747 | 73898 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 292 | 4 | 0 | 3 | 1.9 | COc1ccc(F)c(CN2CCN(C(=O)C3CC3)CC2)c1 | 10.1016/s0960-894x(03)00090-8 | |||
44396136 | 175203 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 385 | 5 | 0 | 2 | 5.4 | COc1ccc2c(c1)CCN(C(C)=O)C2CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL434916 | 175203 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 385 | 5 | 0 | 2 | 5.4 | COc1ccc2c(c1)CCN(C(C)=O)C2CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
44395939 | 130463 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 471 | 10 | 0 | 3 | 6.9 | CCCCCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL362162 | 130463 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 471 | 10 | 0 | 3 | 6.9 | CCCCCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
22375366 | 76268 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 300 | 3 | 0 | 3 | 2.2 | COc1ccc2c(c1)C(N1CCN(C(=O)C3CC3)CC1)CC2 | 10.1016/s0960-894x(03)00090-8 | |||
CHEMBL19339 | 76268 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 300 | 3 | 0 | 3 | 2.2 | COc1ccc2c(c1)C(N1CCN(C(=O)C3CC3)CC1)CC2 | 10.1016/s0960-894x(03)00090-8 | |||
22375392 | 105958 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 303 | 3 | 1 | 3 | 2.0 | CCNC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1 | 10.1016/s0960-894x(03)00090-8 | |||
CHEMBL281345 | 105958 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 303 | 3 | 1 | 3 | 2.0 | CCNC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1 | 10.1016/s0960-894x(03)00090-8 | |||
11247050 | 73641 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 416 | 6 | 1 | 3 | 4.9 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(N)=O)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL186262 | 73641 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 416 | 6 | 1 | 3 | 4.9 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(N)=O)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
44396034 | 134081 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 455 | 7 | 0 | 3 | 6.2 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C1CCC1)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL365899 | 134081 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 455 | 7 | 0 | 3 | 6.2 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C1CCC1)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
22375417 | 74038 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 288 | 3 | 0 | 3 | 2.2 | CCC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1 | 10.1016/s0960-894x(03)00090-8 | |||
CHEMBL18810 | 74038 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 288 | 3 | 0 | 3 | 2.2 | CCC(=O)N1CCN(C2CCc3ccc(OC)cc32)CC1 | 10.1016/s0960-894x(03)00090-8 | |||
44395994 | 73511 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 483 | 7 | 0 | 3 | 6.9 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C1CCCCC1)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL185733 | 73511 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 483 | 7 | 0 | 3 | 6.9 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)C1CCCCC1)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
18175008 | 182274 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 292 | 4 | 2 | 3 | 1.2 | CC(=O)NCCc1cccc2ccc(S(N)(=O)=O)cc12 | 10.1016/j.ejmech.2011.02.010 | |||
CHEMBL457763 | 182274 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 292 | 4 | 2 | 3 | 1.2 | CC(=O)NCCc1cccc2ccc(S(N)(=O)=O)cc12 | 10.1016/j.ejmech.2011.02.010 | |||
9861677 | 194338 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 315 | 5 | 1 | 4 | 3.1 | COC(=O)c1ccc2occ(CCNC(=O)C3CCCC3)c2c1 | 10.1016/j.bmc.2008.03.036 | |||
CHEMBL494566 | 194338 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 315 | 5 | 1 | 4 | 3.1 | COC(=O)c1ccc2occ(CCNC(=O)C3CCCC3)c2c1 | 10.1016/j.bmc.2008.03.036 | |||
44396073 | 73926 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 485 | 11 | 0 | 3 | 7.3 | CCCCCCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL187592 | 73926 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 485 | 11 | 0 | 3 | 7.3 | CCCCCCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
4284525 | 195493 | 42 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 275 | 4 | 3 | 3 | 2.0 | COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2011.02.010 | |||
CHEMBL504585 | 195493 | 42 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 275 | 4 | 3 | 3 | 2.0 | COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2011.02.010 | |||
4284525 | 195493 | 42 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 275 | 4 | 3 | 3 | 2.0 | COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.03.036 | |||
CHEMBL504585 | 195493 | 42 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 275 | 4 | 3 | 3 | 2.0 | COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.03.036 | |||
22037991 | 105447 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 274 | 2 | 0 | 3 | 1.8 | COc1ccc2c(c1)C(N1CCN(C(C)=O)CC1)CC2 | 10.1016/s0960-894x(03)00090-8 | |||
CHEMBL277429 | 105447 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 274 | 2 | 0 | 3 | 1.8 | COc1ccc2c(c1)C(N1CCN(C(C)=O)CC1)CC2 | 10.1016/s0960-894x(03)00090-8 | |||
44395915 | 73820 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 415 | 6 | 0 | 3 | 5.4 | COc1cc2c(c(OC)c1)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL187136 | 73820 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 415 | 6 | 0 | 3 | 5.4 | COc1cc2c(c(OC)c1)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
17957007 | 199434 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 304 | 5 | 2 | 4 | 2.9 | COC(=O)Nc1ccc2occ(CCNC(=O)C(C)C)c2c1 | 10.1016/j.bmc.2008.03.036 | |||
CHEMBL521826 | 199434 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 304 | 5 | 2 | 4 | 2.9 | COC(=O)Nc1ccc2occ(CCNC(=O)C(C)C)c2c1 | 10.1016/j.bmc.2008.03.036 | |||
9064 | 111996 | 94 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 290 | 1 | 5 | 6 | 1.5 | Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2 | 10.1016/j.bmc.2021.116270 | |||
CHEMBL311498 | 111996 | 94 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 290 | 1 | 5 | 6 | 1.5 | Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2 | 10.1016/j.bmc.2021.116270 | |||
11749479 | 73672 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 385 | 5 | 0 | 2 | 5.4 | COc1ccc2c(c1)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL186452 | 73672 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 385 | 5 | 0 | 2 | 5.4 | COc1ccc2c(c1)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
44576406 | 194149 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 330 | 5 | 2 | 4 | 3.5 | COC(=O)Nc1ccc2occ(CCNC(=O)C3CCCC3)c2c1 | 10.1016/j.bmc.2008.03.036 | |||
CHEMBL493414 | 194149 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 330 | 5 | 2 | 4 | 3.5 | COC(=O)Nc1ccc2occ(CCNC(=O)C3CCCC3)c2c1 | 10.1016/j.bmc.2008.03.036 | |||
44593610 | 194151 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 302 | 6 | 2 | 4 | 2.8 | C=CCC(=O)NCCc1coc2ccc(NC(=O)OC)cc12 | 10.1016/j.bmc.2008.03.036 | |||
CHEMBL493424 | 194151 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 302 | 6 | 2 | 4 | 2.8 | C=CCC(=O)NCCc1coc2ccc(NC(=O)OC)cc12 | 10.1016/j.bmc.2008.03.036 | |||
25014882 | 194474 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 302 | 5 | 2 | 4 | 2.7 | COC(=O)Nc1ccc2occ(CCNC(=O)C3CC3)c2c1 | 10.1016/j.bmc.2008.03.036 | |||
CHEMBL495232 | 194474 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 302 | 5 | 2 | 4 | 2.7 | COC(=O)Nc1ccc2occ(CCNC(=O)C3CC3)c2c1 | 10.1016/j.bmc.2008.03.036 | |||
23725566 | 132629 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 272 | 4 | 1 | 3 | 3.1 | CCC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21 | nan | |||
CHEMBL3648360 | 132629 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 272 | 4 | 1 | 3 | 3.1 | CCC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21 | nan | |||
53827707 | 117643 | 3 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 279 | 6 | 1 | 3 | 3.0 | CCCNC(=O)CCCc1cccc2c1SCCO2 | 10.1021/jm401343c | |||
CHEMBL3260981 | 117643 | 3 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 279 | 6 | 1 | 3 | 3.0 | CCCNC(=O)CCCc1cccc2c1SCCO2 | 10.1021/jm401343c | |||
11304981 | 73702 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 430 | 6 | 1 | 3 | 5.2 | CNC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL186590 | 73702 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 430 | 6 | 1 | 3 | 5.2 | CNC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
11304958 | 74040 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 429 | 7 | 0 | 3 | 5.8 | CCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL188120 | 74040 | 0 | None | - | 0 | Human | 7.2 | pIC50 | = | 7.2 | Binding | ChEMBL | 429 | 7 | 0 | 3 | 5.8 | CCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
18175032 | 182375 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 358 | 6 | 2 | 4 | 2.3 | CNS(=O)(=O)c1ccc2cccc(CCNC(=O)c3ccco3)c2c1 | 10.1016/j.ejmech.2011.02.010 | |||
CHEMBL457992 | 182375 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 358 | 6 | 2 | 4 | 2.3 | CNS(=O)(=O)c1ccc2cccc(CCNC(=O)c3ccco3)c2c1 | 10.1016/j.ejmech.2011.02.010 | |||
22375402 | 105133 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 314 | 3 | 0 | 3 | 2.6 | COc1ccc2c(c1)C(N1CCN(C(=O)C3CC3)CC1)CCC2 | 10.1016/s0960-894x(03)00090-8 | |||
CHEMBL275205 | 105133 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 314 | 3 | 0 | 3 | 2.6 | COc1ccc2c(c1)C(N1CCN(C(=O)C3CC3)CC1)CCC2 | 10.1016/s0960-894x(03)00090-8 | |||
44396074 | 73927 | 2 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 339 | 5 | 0 | 3 | 3.8 | COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(C)=O)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL187593 | 73927 | 2 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 339 | 5 | 0 | 3 | 3.8 | COc1cc2c(cc1OC)C(CCc1ccccc1)N(C(C)=O)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
11476283 | 73671 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 443 | 8 | 0 | 3 | 6.2 | CCCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL186451 | 73671 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 443 | 8 | 0 | 3 | 6.2 | CCCC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1 | 10.1016/j.bmcl.2004.09.024 | |||
23725568 | 132633 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 274 | 3 | 1 | 3 | 3.2 | CC(=O)NCC[C@H]1CCc2ccc3nc(C)sc3c21 | nan | |||
CHEMBL3648364 | 132633 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 274 | 3 | 1 | 3 | 3.2 | CC(=O)NCC[C@H]1CCc2ccc3nc(C)sc3c21 | nan | |||
44396100 | 128826 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 545 | 7 | 0 | 3 | 7.7 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)c1ccc(C(F)(F)F)cc1)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL359576 | 128826 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 545 | 7 | 0 | 3 | 7.7 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(=O)c1ccc(C(F)(F)F)cc1)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
10663827 | 129705 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 325 | 6 | 0 | 3 | 3.4 | COc1cc2c(cc1OC)C(CCc1ccccc1)N(C=O)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL360641 | 129705 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 325 | 6 | 0 | 3 | 3.4 | COc1cc2c(cc1OC)C(CCc1ccccc1)N(C=O)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
21916760 | 182478 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 291 | 4 | 1 | 3 | 1.9 | CC(=O)NCCc1cccc2ccc(S(C)(=O)=O)cc12 | 10.1016/j.ejmech.2011.02.010 | |||
CHEMBL458209 | 182478 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 291 | 4 | 1 | 3 | 1.9 | CC(=O)NCCc1cccc2ccc(S(C)(=O)=O)cc12 | 10.1016/j.ejmech.2011.02.010 | |||
23725513 | 132626 | 0 | None | 3 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 258 | 3 | 1 | 3 | 2.7 | CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21 | nan | |||
CHEMBL3648357 | 132626 | 0 | None | 3 | 2 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 258 | 3 | 1 | 3 | 2.7 | CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21 | nan | |||
9909783 | 73910 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 415 | 6 | 0 | 3 | 5.4 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL187525 | 73910 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 415 | 6 | 0 | 3 | 5.4 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
11361621 | 132585 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 401 | 7 | 0 | 3 | 5.0 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C=O)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
CHEMBL364816 | 132585 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 401 | 7 | 0 | 3 | 5.0 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C=O)CC2 | 10.1016/j.bmcl.2004.09.024 | |||
44272521 | 77088 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 310 | 3 | 0 | 3 | 2.9 | COc1ccc2cccc(N3CCN(C(=O)C4CC4)CC3)c2c1 | 10.1016/s0960-894x(03)00090-8 | |||
CHEMBL19442 | 77088 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 310 | 3 | 0 | 3 | 2.9 | COc1ccc2cccc(N3CCN(C(=O)C4CC4)CC3)c2c1 | 10.1016/s0960-894x(03)00090-8 | |||
22375407 | 77413 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 317 | 3 | 1 | 3 | 2.4 | CCNC(=O)N1CCN(C2CCCc3ccc(OC)cc32)CC1 | 10.1016/s0960-894x(03)00090-8 | |||
CHEMBL19503 | 77413 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 317 | 3 | 1 | 3 | 2.4 | CCNC(=O)N1CCN(C2CCCc3ccc(OC)cc32)CC1 | 10.1016/s0960-894x(03)00090-8 | |||
9817006 | 181763 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 275 | 4 | 1 | 2 | 2.3 | CC(=O)NCCc1cccc2ccc([S+](C)[O-])cc12 | 10.1016/j.ejmech.2011.02.010 | |||
CHEMBL456646 | 181763 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 275 | 4 | 1 | 2 | 2.3 | CC(=O)NCCc1cccc2ccc([S+](C)[O-])cc12 | 10.1016/j.ejmech.2011.02.010 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKd | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1039/C5MD00190K | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKd | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1039/C5MD00190K | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKd | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1039/C5MD00190K | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKd | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1039/C5MD00190K | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKd | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1039/C5MD00190K | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKd | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1039/C5MD00190K | |||
10440 | 9458 | 20 | None | -3 | 3 | Human | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 417 | 7 | 3 | 7 | 4.2 | OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F | 10.1021/acs.jmedchem.9b00869 | |||
139030523 | 9458 | 20 | None | -3 | 3 | Human | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 417 | 7 | 3 | 7 | 4.2 | OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F | 10.1021/acs.jmedchem.9b00869 | |||
CHEMBL4449712 | 9458 | 20 | None | -3 | 3 | Human | 6.0 | pKd | = | 6.0 | Binding | ChEMBL | 417 | 7 | 3 | 7 | 4.2 | OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F | 10.1021/acs.jmedchem.9b00869 | |||
11723593 | 113655 | 0 | None | 1 | 2 | Human | 11.0 | pKi | = | 11 | Binding | ChEMBL | 321 | 6 | 1 | 3 | 4.0 | C=CC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
CHEMBL314512 | 113655 | 0 | None | 1 | 2 | Human | 11.0 | pKi | = | 11 | Binding | ChEMBL | 321 | 6 | 1 | 3 | 4.0 | C=CC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
53237949 | 68791 | 0 | None | 3 | 2 | Human | 11.0 | pKi | = | 11 | Binding | ChEMBL | 339 | 4 | 1 | 2 | 3.7 | CC(C)C1=C(CCNC(=O)C(F)(F)F)c2c(ccc3c2CCO3)C1 | 10.1021/jm200221q | |||
CHEMBL1774516 | 68791 | 0 | None | 3 | 2 | Human | 11.0 | pKi | = | 11 | Binding | ChEMBL | 339 | 4 | 1 | 2 | 3.7 | CC(C)C1=C(CCNC(=O)C(F)(F)F)c2c(ccc3c2CCO3)C1 | 10.1021/jm200221q | |||
53237947 | 68789 | 0 | None | 1 | 2 | Human | 11.0 | pKi | = | 11.0 | Binding | ChEMBL | 299 | 5 | 1 | 2 | 3.5 | CCC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3 | 10.1021/jm200221q | |||
CHEMBL1774514 | 68789 | 0 | None | 1 | 2 | Human | 11.0 | pKi | = | 11.0 | Binding | ChEMBL | 299 | 5 | 1 | 2 | 3.5 | CCC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3 | 10.1021/jm200221q | |||
53238410 | 68802 | 0 | None | 1174 | 2 | Human | 11.0 | pKi | = | 11.0 | Binding | ChEMBL | 361 | 5 | 1 | 2 | 4.7 | CC(=O)NCCC1=C(c2cccc(C(C)C)c2)Cc2ccc3c(c21)CCO3 | 10.1021/jm200221q | |||
CHEMBL1774529 | 68802 | 0 | None | 1174 | 2 | Human | 11.0 | pKi | = | 11.0 | Binding | ChEMBL | 361 | 5 | 1 | 2 | 4.7 | CC(=O)NCCC1=C(c2cccc(C(C)C)c2)Cc2ccc3c(c21)CCO3 | 10.1021/jm200221q | |||
53238181 | 7721 | 0 | None | 741 | 2 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 339 | 5 | 1 | 2 | 4.4 | CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2 | 10.1021/jm200221q | |||
7780 | 7721 | 0 | None | 741 | 2 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 339 | 5 | 1 | 2 | 4.4 | CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2 | 10.1021/jm200221q | |||
CHEMBL1774519 | 7721 | 0 | None | 741 | 2 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 339 | 5 | 1 | 2 | 4.4 | CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2 | 10.1021/jm200221q | |||
53238183 | 68795 | 2 | None | - | 1 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 321 | 3 | 1 | 2 | 2.8 | CC(=O)NCCC1=C(Br)Cc2ccc3c(c21)CCO3 | 10.1021/jm200221q | |||
CHEMBL1774521 | 68795 | 2 | None | - | 1 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 321 | 3 | 1 | 2 | 2.8 | CC(=O)NCCC1=C(Br)Cc2ccc3c(c21)CCO3 | 10.1021/jm200221q | |||
1358 | 6912 | 41 | None | 870 | 2 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | 10.1021/jm048956y | |||
3976006 | 6912 | 41 | None | 870 | 2 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | 10.1021/jm048956y | |||
CHEMBL285718 | 6912 | 41 | None | 870 | 2 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | 10.1021/jm048956y | |||
53237946 | 68788 | 0 | None | 1 | 2 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 285 | 4 | 1 | 2 | 3.1 | CC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3 | 10.1021/jm200221q | |||
CHEMBL1774513 | 68788 | 0 | None | 1 | 2 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 285 | 4 | 1 | 2 | 3.1 | CC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3 | 10.1021/jm200221q | |||
9839629 | 106892 | 0 | None | -1 | 2 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 309 | 5 | 1 | 3 | 3.8 | COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
CHEMBL287560 | 106892 | 0 | None | -1 | 2 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 309 | 5 | 1 | 3 | 3.8 | COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
10925712 | 119357 | 0 | None | -1 | 2 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 335 | 7 | 1 | 3 | 4.3 | C=CCC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
CHEMBL330137 | 119357 | 0 | None | -1 | 2 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 335 | 7 | 1 | 3 | 4.3 | C=CCC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
9839629 | 106892 | 0 | None | -1 | 2 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 309 | 5 | 1 | 3 | 3.8 | COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/acs.jmedchem.5b00982 | |||
CHEMBL287560 | 106892 | 0 | None | -1 | 2 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 309 | 5 | 1 | 3 | 3.8 | COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/acs.jmedchem.5b00982 | |||
53238186 | 68798 | 0 | None | 54 | 2 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 349 | 5 | 1 | 3 | 3.6 | COc1ccccc1C1=C(CCNC(C)=O)c2c(ccc3c2CCO3)C1 | 10.1021/jm200221q | |||
CHEMBL1774525 | 68798 | 0 | None | 54 | 2 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 349 | 5 | 1 | 3 | 3.6 | COc1ccccc1C1=C(CCNC(C)=O)c2c(ccc3c2CCO3)C1 | 10.1021/jm200221q | |||
22004791 | 68787 | 0 | None | 2 | 2 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 243 | 3 | 1 | 2 | 2.1 | CC(=O)NCCC1=CCc2ccc3c(c21)CCO3 | 10.1021/jm200221q | |||
CHEMBL1774512 | 68787 | 0 | None | 2 | 2 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 243 | 3 | 1 | 2 | 2.1 | CC(=O)NCCC1=CCc2ccc3c(c21)CCO3 | 10.1021/jm200221q | |||
24750077 | 155823 | 0 | None | 691 | 2 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 314 | 7 | 1 | 4 | 3.0 | COc1cccc(N(CCNC(C)=O)c2cccc(OC)c2)c1 | 10.1021/jm700957j | |||
CHEMBL394273 | 155823 | 0 | None | 691 | 2 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 314 | 7 | 1 | 4 | 3.0 | COc1cccc(N(CCNC(C)=O)c2cccc(OC)c2)c1 | 10.1021/jm700957j | |||
137642160 | 165171 | 0 | None | 165 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 308 | 5 | 1 | 5 | 1.3 | COc1ccc2cccc(CCC(=O)NS(C)(=O)=O)c2n1 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4089965 | 165171 | 0 | None | 165 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 308 | 5 | 1 | 5 | 1.3 | COc1ccc2cccc(CCC(=O)NS(C)(=O)=O)c2n1 | 10.1016/j.ejmech.2016.12.013 | |||
127042442 | 144689 | 0 | None | 6 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 328 | 5 | 1 | 4 | 3.3 | COc1ccc2oc(-c3ccc(F)cc3)c(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
CHEMBL3763503 | 144689 | 0 | None | 6 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 328 | 5 | 1 | 4 | 3.3 | COc1ccc2oc(-c3ccc(F)cc3)c(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
71533430 | 93189 | 0 | None | 1 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 241 | 3 | 1 | 2 | 3.0 | COc1ccc2cccc(/C=C/NC(C)=O)c2c1 | 10.1016/j.bmcl.2012.11.069 | |||
CHEMBL2314255 | 93189 | 0 | None | 1 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 241 | 3 | 1 | 2 | 3.0 | COc1ccc2cccc(/C=C/NC(C)=O)c2c1 | 10.1016/j.bmcl.2012.11.069 | |||
46884551 | 14957 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 373 | 10 | 1 | 5 | 3.4 | COc1cc(COc2ccc(OC)cc2CCCNC(C)=O)cc(OC)c1 | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL1091998 | 14957 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 373 | 10 | 1 | 5 | 3.4 | COc1cc(COc2ccc(OC)cc2CCCNC(C)=O)cc(OC)c1 | 10.1016/j.bmcl.2010.02.084 | |||
18466111 | 26617 | 0 | None | -1 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 283 | 5 | 1 | 2 | 3.4 | CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
CHEMBL130214 | 26617 | 0 | None | -1 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 283 | 5 | 1 | 2 | 3.4 | CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
53238185 | 68797 | 0 | None | 2 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 320 | 4 | 1 | 3 | 3.0 | CC(=O)NCCC1=C(c2cccnc2)Cc2ccc3c(c21)CCO3 | 10.1021/jm200221q | |||
CHEMBL1774524 | 68797 | 0 | None | 2 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 320 | 4 | 1 | 3 | 3.0 | CC(=O)NCCC1=C(c2cccnc2)Cc2ccc3c(c21)CCO3 | 10.1021/jm200221q | |||
53237948 | 68790 | 0 | None | 3 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 311 | 5 | 1 | 2 | 3.5 | CC(C)C1=C(CCNC(=O)C2CC2)c2c(ccc3c2CCO3)C1 | 10.1021/jm200221q | |||
CHEMBL1774515 | 68790 | 0 | None | 3 | 2 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 311 | 5 | 1 | 2 | 3.5 | CC(C)C1=C(CCNC(=O)C2CC2)c2c(ccc3c2CCO3)C1 | 10.1021/jm200221q | |||
53238408 | 68800 | 0 | None | 81 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 349 | 5 | 1 | 3 | 3.6 | COc1ccc(C2=C(CCNC(C)=O)c3c(ccc4c3CCO4)C2)cc1 | 10.1021/jm200221q | |||
CHEMBL1774527 | 68800 | 0 | None | 81 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 349 | 5 | 1 | 3 | 3.6 | COc1ccc(C2=C(CCNC(C)=O)c3c(ccc4c3CCO4)C2)cc1 | 10.1021/jm200221q | |||
1351 | 9174 | 21 | None | 1 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 280 | 4 | 2 | 2 | 3.1 | COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C | 10.1039/C4MD00149D | |||
219018 | 9174 | 21 | None | 1 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 280 | 4 | 2 | 2 | 3.1 | COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C | 10.1039/C4MD00149D | |||
CHEMBL4079759 | 9174 | 21 | None | 1 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 280 | 4 | 2 | 2 | 3.1 | COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C | 10.1039/C4MD00149D | |||
9873402 | 42613 | 0 | None | -1 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 596 | 19 | 2 | 4 | 7.9 | CC(=O)NCCc1cccc2ccc(OCCCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 | 10.1021/jm0255872 | |||
CHEMBL14417 | 42613 | 0 | None | -1 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 596 | 19 | 2 | 4 | 7.9 | CC(=O)NCCc1cccc2ccc(OCCCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 | 10.1021/jm0255872 | |||
10925379 | 214344 | 0 | None | -1 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 324 | 5 | 2 | 3 | 3.6 | CNC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
CHEMBL94838 | 214344 | 0 | None | -1 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 324 | 5 | 2 | 3 | 3.6 | CNC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
44272335 | 75451 | 0 | None | 23 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 302 | 7 | 2 | 3 | 3.6 | CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCC)N2 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL19211 | 75451 | 0 | None | 23 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 302 | 7 | 2 | 3 | 3.6 | CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCC)N2 | 10.1016/j.bmcl.2003.12.052 | |||
1356 | 10061 | 99 | None | -3 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 10.1021/jm0201159 | |||
208902 | 10061 | 99 | None | -3 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 10.1021/jm0201159 | |||
2355 | 10061 | 99 | None | -3 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 10.1021/jm0201159 | |||
CHEMBL1218 | 10061 | 99 | None | -3 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 10.1021/jm0201159 | |||
DB00980 | 10061 | 99 | None | -3 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 10.1021/jm0201159 | |||
11100761 | 108568 | 4 | None | 1 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 372 | 4 | 1 | 3 | 2.5 | COc1ccc2c(c1)c(CCNC(C)=O)c(I)n2C | 10.1021/jm011053+ | |||
CHEMBL300056 | 108568 | 4 | None | 1 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 372 | 4 | 1 | 3 | 2.5 | COc1ccc2c(c1)c(CCNC(C)=O)c(I)n2C | 10.1021/jm011053+ | |||
46885226 | 14844 | 0 | None | 18620 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 313 | 8 | 1 | 3 | 3.3 | COc1ccc(OCc2ccccc2)c(CCCNC(C)=O)c1 | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL1091160 | 14844 | 0 | None | 18620 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 313 | 8 | 1 | 3 | 3.3 | COc1ccc(OCc2ccccc2)c(CCCNC(C)=O)c1 | 10.1016/j.bmcl.2010.02.084 | |||
9927219 | 119099 | 0 | None | 25 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 323 | 6 | 1 | 3 | 3.7 | COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
CHEMBL329263 | 119099 | 0 | None | 25 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 323 | 6 | 1 | 3 | 3.7 | COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
1350 | 8771 | 0 | None | 1 | 3 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 348 | 6 | 1 | 3 | 4.1 | CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 | 10.1021/jm980684+ | |||
4172142 | 8771 | 0 | None | 1 | 3 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 348 | 6 | 1 | 3 | 4.1 | CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 | 10.1021/jm980684+ | |||
CHEMBL10009 | 8771 | 0 | None | 1 | 3 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 348 | 6 | 1 | 3 | 4.1 | CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 | 10.1021/jm980684+ | |||
9927219 | 119099 | 0 | None | 25 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 323 | 6 | 1 | 3 | 3.7 | COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/acs.jmedchem.5b00982 | |||
CHEMBL329263 | 119099 | 0 | None | 25 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 323 | 6 | 1 | 3 | 3.7 | COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/acs.jmedchem.5b00982 | |||
9927219 | 119099 | 0 | None | 25 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 323 | 6 | 1 | 3 | 3.7 | COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/jm401343c | |||
CHEMBL329263 | 119099 | 0 | None | 25 | 2 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 323 | 6 | 1 | 3 | 3.7 | COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/jm401343c | |||
1350 | 8771 | 0 | None | 1 | 3 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 348 | 6 | 1 | 3 | 4.1 | CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 | 10.1021/jm401343c | |||
4172142 | 8771 | 0 | None | 1 | 3 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 348 | 6 | 1 | 3 | 4.1 | CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 | 10.1021/jm401343c | |||
CHEMBL10009 | 8771 | 0 | None | 1 | 3 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 348 | 6 | 1 | 3 | 4.1 | CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 | 10.1021/jm401343c | |||
164621472 | 192674 | 0 | None | -2 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 288 | 4 | 1 | 3 | 3.6 | CCC(=O)NCCC1CCc2ccc3nc(C)sc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL4868554 | 192674 | 0 | None | -2 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 288 | 4 | 1 | 3 | 3.6 | CCC(=O)NCCC1CCc2ccc3nc(C)sc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
10926138 | 214756 | 0 | None | 57 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 349 | 8 | 1 | 3 | 4.3 | C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
CHEMBL97186 | 214756 | 0 | None | 57 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 349 | 8 | 1 | 3 | 4.3 | C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
9858255 | 214856 | 0 | None | 30 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 320 | 4 | 1 | 3 | 3.4 | COc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1 | 10.1021/jm980684+ | |||
CHEMBL9772 | 214856 | 0 | None | 30 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 320 | 4 | 1 | 3 | 3.4 | COc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1 | 10.1021/jm980684+ | |||
16656789 | 95326 | 0 | None | 63 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 284 | 6 | 1 | 3 | 3.0 | COc1cccc(N(CCNC(C)=O)c2ccccc2)c1 | 10.1021/jm700957j | |||
CHEMBL235327 | 95326 | 0 | None | 63 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 284 | 6 | 1 | 3 | 3.0 | COc1cccc(N(CCNC(C)=O)c2ccccc2)c1 | 10.1021/jm700957j | |||
9839199 | 28135 | 0 | None | 1 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 297 | 5 | 1 | 2 | 3.8 | CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23 | 10.1021/jm000922c | |||
CHEMBL131424 | 28135 | 0 | None | 1 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 297 | 5 | 1 | 2 | 3.8 | CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23 | 10.1021/jm000922c | |||
9904304 | 27917 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 297 | 5 | 1 | 2 | 3.8 | CCCC(=O)NCC1CCc2cccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
CHEMBL131252 | 27917 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 297 | 5 | 1 | 2 | 3.8 | CCCC(=O)NCC1CCc2cccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
10452167 | 85564 | 0 | None | -1 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 376 | 9 | 1 | 3 | 5.0 | CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL2112690 | 85564 | 0 | None | -1 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 376 | 9 | 1 | 3 | 5.0 | CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12 | 10.1016/j.bmcl.2003.12.052 | |||
145982333 | 173336 | 0 | None | -1 | 3 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 284 | 3 | 2 | 2 | 2.8 | CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4279639 | 173336 | 0 | None | -1 | 3 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 284 | 3 | 2 | 2 | 2.8 | CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
57781216 | 132625 | 0 | None | -2 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 258 | 3 | 1 | 3 | 2.7 | CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL3648356 | 132625 | 0 | None | -2 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 258 | 3 | 1 | 3 | 2.7 | CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
71533431 | 6866 | 0 | None | -2 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 271 | 4 | 1 | 3 | 3.0 | COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC | 10.1016/j.bmcl.2012.11.069 | |||
7775 | 6866 | 0 | None | -2 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 271 | 4 | 1 | 3 | 3.0 | COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC | 10.1016/j.bmcl.2012.11.069 | |||
CHEMBL2314259 | 6866 | 0 | None | -2 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 271 | 4 | 1 | 3 | 3.0 | COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC | 10.1016/j.bmcl.2012.11.069 | |||
57781227 | 132623 | 0 | None | 6 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 244 | 3 | 1 | 3 | 2.4 | CC(=O)NCCC1CCc2ccc3ncoc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL3648354 | 132623 | 0 | None | 6 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 244 | 3 | 1 | 3 | 2.4 | CC(=O)NCCC1CCc2ccc3ncoc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
71508232 | 93848 | 0 | None | 524 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 351 | 7 | 1 | 3 | 3.6 | CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1 | 10.1016/j.bmc.2012.10.060 | |||
CHEMBL2326200 | 93848 | 0 | None | 524 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 351 | 7 | 1 | 3 | 3.6 | CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1 | 10.1016/j.bmc.2012.10.060 | |||
44272320 | 105378 | 0 | None | 2 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 288 | 6 | 2 | 3 | 3.2 | CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)CC)c2O1 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL276921 | 105378 | 0 | None | 2 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 288 | 6 | 2 | 3 | 3.2 | CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)CC)c2O1 | 10.1016/j.bmcl.2003.12.052 | |||
127042791 | 144838 | 0 | None | 2 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 360 | 4 | 1 | 4 | 2.1 | COc1ccc2oc(I)c(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
CHEMBL3765401 | 144838 | 0 | None | 2 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 360 | 4 | 1 | 4 | 2.1 | COc1ccc2oc(I)c(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
53237950 | 68792 | 0 | None | 13 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 314 | 5 | 2 | 2 | 3.3 | CCNC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3 | 10.1021/jm200221q | |||
CHEMBL1774517 | 68792 | 0 | None | 13 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 314 | 5 | 2 | 2 | 3.3 | CCNC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3 | 10.1021/jm200221q | |||
10659603 | 27028 | 0 | None | 1 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 269 | 4 | 1 | 2 | 3.0 | CCC(=O)NCC1Cc2cccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
CHEMBL130542 | 27028 | 0 | None | 1 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 269 | 4 | 1 | 2 | 3.0 | CCC(=O)NCC1Cc2cccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
24955343 | 70566 | 0 | None | -1 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 321 | 4 | 1 | 4 | 2.6 | CC(=O)NCCc1c(-c2ccccc2)nn2ccc3c(c12)CCO3 | 10.1021/jm200385u | |||
CHEMBL1802022 | 70566 | 0 | None | -1 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 321 | 4 | 1 | 4 | 2.6 | CC(=O)NCCc1c(-c2ccccc2)nn2ccc3c(c12)CCO3 | 10.1021/jm200385u | |||
23725567 | 132631 | 0 | None | -2 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 274 | 3 | 1 | 3 | 3.2 | CC(=O)NCCC1CCc2ccc3nc(C)sc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL3648362 | 132631 | 0 | None | -2 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 274 | 3 | 1 | 3 | 3.2 | CC(=O)NCCC1CCc2ccc3nc(C)sc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
23725514 | 132627 | 0 | None | -1 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 272 | 4 | 1 | 3 | 3.1 | CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL3648358 | 132627 | 0 | None | -1 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 272 | 4 | 1 | 3 | 3.1 | CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
127026423 | 144597 | 0 | None | 31 | 3 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 283 | 4 | 1 | 3 | 3.3 | COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL3759802 | 144597 | 0 | None | 31 | 3 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 283 | 4 | 1 | 3 | 3.3 | COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
137636213 | 162865 | 0 | None | 8 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 273 | 5 | 2 | 3 | 2.1 | CCNC(=O)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4062947 | 162865 | 0 | None | 8 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 273 | 5 | 2 | 3 | 2.1 | CCNC(=O)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | |||
137647756 | 164723 | 0 | None | 6 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 259 | 4 | 2 | 3 | 1.7 | CNC(=O)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4084612 | 164723 | 0 | None | 6 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 259 | 4 | 2 | 3 | 1.7 | CNC(=O)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | |||
127040021 | 144797 | 0 | None | 24 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 360 | 5 | 1 | 4 | 4.3 | COc1ccc2oc(-c3ccc4ccccc4c3)c(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
CHEMBL3764765 | 144797 | 0 | None | 24 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 360 | 5 | 1 | 4 | 4.3 | COc1ccc2oc(-c3ccc4ccccc4c3)c(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
71540389 | 93190 | 0 | None | 1 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 241 | 3 | 1 | 2 | 3.0 | COc1ccc2ccccc2c1/C=C/NC(C)=O | 10.1016/j.bmcl.2012.11.069 | |||
CHEMBL2314257 | 93190 | 0 | None | 1 | 2 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 241 | 3 | 1 | 2 | 3.0 | COc1ccc2ccccc2c1/C=C/NC(C)=O | 10.1016/j.bmcl.2012.11.069 | |||
10515048 | 123589 | 0 | None | 8 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 253 | 4 | 1 | 1 | 3.4 | CCCC(=O)NCC1Cc2cccc3cccc1c23 | 10.1021/jm000922c | |||
CHEMBL337882 | 123589 | 0 | None | 8 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 253 | 4 | 1 | 1 | 3.4 | CCCC(=O)NCC1Cc2cccc3cccc1c23 | 10.1021/jm000922c | |||
9903515 | 29565 | 0 | None | -9 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 269 | 3 | 1 | 2 | 3.0 | COc1ccc2cccc3c2c1C(CNC(C)=O)CC3 | 10.1021/jm000922c | |||
CHEMBL132802 | 29565 | 0 | None | -9 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 269 | 3 | 1 | 2 | 3.0 | COc1ccc2cccc3c2c1C(CNC(C)=O)CC3 | 10.1021/jm000922c | |||
9797460 | 124931 | 0 | None | -6 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 327 | 6 | 1 | 3 | 3.8 | CCCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
CHEMBL340832 | 124931 | 0 | None | -6 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 327 | 6 | 1 | 3 | 3.8 | CCCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
44264769 | 103772 | 0 | None | 10 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 298 | 6 | 1 | 3 | 4.2 | CCCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL266549 | 103772 | 0 | None | 10 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 298 | 6 | 1 | 3 | 4.2 | CCCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
145982070 | 173254 | 0 | None | -1 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 283 | 3 | 1 | 2 | 3.2 | COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4278248 | 173254 | 0 | None | -1 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 283 | 3 | 1 | 2 | 3.2 | COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | |||
145981162 | 173276 | 0 | None | 3 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 270 | 3 | 2 | 2 | 2.5 | COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4278575 | 173276 | 0 | None | 3 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 270 | 3 | 2 | 2 | 2.5 | COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | |||
145982167 | 173390 | 0 | None | 7 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 305 | 4 | 1 | 3 | 2.4 | COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4280601 | 173390 | 0 | None | 7 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 305 | 4 | 1 | 3 | 2.4 | COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | |||
145979282 | 173454 | 0 | None | 16 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 300 | 3 | 2 | 2 | 3.0 | CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4281915 | 173454 | 0 | None | 16 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 300 | 3 | 2 | 2 | 3.0 | CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
145987794 | 173899 | 0 | None | 19 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 298 | 4 | 2 | 2 | 3.2 | CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4290302 | 173899 | 0 | None | 19 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 298 | 4 | 2 | 2 | 3.2 | CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
145988741 | 174015 | 0 | None | 6 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 299 | 5 | 1 | 3 | 2.6 | COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4292336 | 174015 | 0 | None | 6 | 3 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 299 | 5 | 1 | 3 | 2.6 | COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
137655238 | 165664 | 0 | None | 19 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 275 | 4 | 2 | 3 | 1.9 | CNC(=S)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4095210 | 165664 | 0 | None | 19 | 2 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 275 | 4 | 2 | 3 | 1.9 | CNC(=S)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | |||
198 | 7101 | 126 | None | 1 | 6 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmcl.2012.11.069 | |||
82148 | 7101 | 126 | None | 1 | 6 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmcl.2012.11.069 | |||
99 | 7101 | 126 | None | 1 | 6 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmcl.2012.11.069 | |||
CHEMBL10878 | 7101 | 126 | None | 1 | 6 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmcl.2012.11.069 | |||
DB06594 | 7101 | 126 | None | 1 | 6 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmcl.2012.11.069 | |||
24750071 | 105696 | 0 | None | 39 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 312 | 8 | 1 | 3 | 3.8 | CCCC(=O)NCCN(c1ccccc1)c1cccc(OC)c1 | 10.1021/jm700957j | |||
CHEMBL279401 | 105696 | 0 | None | 39 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 312 | 8 | 1 | 3 | 3.8 | CCCC(=O)NCCN(c1ccccc1)c1cccc(OC)c1 | 10.1021/jm700957j | |||
9839199 | 28135 | 0 | None | 1 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 297 | 5 | 1 | 2 | 3.8 | CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23 | 10.1021/jm000922c | |||
CHEMBL131424 | 28135 | 0 | None | 1 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 297 | 5 | 1 | 2 | 3.8 | CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23 | 10.1021/jm000922c | |||
10385056 | 119013 | 0 | None | 194 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 379 | 9 | 1 | 4 | 4.3 | C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
CHEMBL329086 | 119013 | 0 | None | 194 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 379 | 9 | 1 | 4 | 4.3 | C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
44581851 | 181990 | 0 | None | 1202 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 333 | 6 | 1 | 2 | 4.5 | COc1cccc(C(CCNC(C)=O)c2ccc3ccccc3c2)c1 | 10.1021/jm800974d | |||
CHEMBL457128 | 181990 | 0 | None | 1202 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 333 | 6 | 1 | 2 | 4.5 | COc1cccc(C(CCNC(C)=O)c2ccc3ccccc3c2)c1 | 10.1021/jm800974d | |||
10385056 | 119013 | 0 | None | 194 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 379 | 9 | 1 | 4 | 4.3 | C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12 | 10.1021/jm401343c | |||
CHEMBL329086 | 119013 | 0 | None | 194 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 379 | 9 | 1 | 4 | 4.3 | C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12 | 10.1021/jm401343c | |||
1356 | 10061 | 99 | None | -3 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 10.1021/acs.jmedchem.0c01836 | |||
208902 | 10061 | 99 | None | -3 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 10.1021/acs.jmedchem.0c01836 | |||
2355 | 10061 | 99 | None | -3 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL1218 | 10061 | 99 | None | -3 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 10.1021/acs.jmedchem.0c01836 | |||
DB00980 | 10061 | 99 | None | -3 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 10.1021/acs.jmedchem.0c01836 | |||
24750189 | 96255 | 0 | None | 1174 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 334 | 6 | 1 | 3 | 4.1 | COc1cccc(N(CCNC(C)=O)c2ccc3ccccc3c2)c1 | 10.1021/jm700957j | |||
CHEMBL237234 | 96255 | 0 | None | 1174 | 2 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 334 | 6 | 1 | 3 | 4.1 | COc1cccc(N(CCNC(C)=O)c2ccc3ccccc3c2)c1 | 10.1021/jm700957j | |||
10562968 | 26967 | 0 | None | -1 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 255 | 3 | 1 | 2 | 2.6 | COc1ccc2cccc3c2c1C(CNC(C)=O)C3 | 10.1021/jm000922c | |||
CHEMBL130490 | 26967 | 0 | None | -1 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 255 | 3 | 1 | 2 | 2.6 | COc1ccc2cccc3c2c1C(CNC(C)=O)C3 | 10.1021/jm000922c | |||
44264818 | 212004 | 0 | None | 91 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 283 | 6 | 1 | 2 | 4.0 | CCCC(=O)Nc1ccc(Cc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7867 | 212004 | 0 | None | 91 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 283 | 6 | 1 | 2 | 4.0 | CCCC(=O)Nc1ccc(Cc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
10712733 | 215221 | 0 | None | 48 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 348 | 5 | 1 | 3 | 3.9 | CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2 | 10.1021/jm980684+ | |||
CHEMBL9997 | 215221 | 0 | None | 48 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 348 | 5 | 1 | 3 | 3.9 | CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2 | 10.1021/jm980684+ | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c00627 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c00627 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c00627 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c00627 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c00627 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c00627 | |||
57781240 | 192767 | 0 | None | 36 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 334 | 5 | 1 | 3 | 4.0 | CC(=O)NCCC1CCc2ccc3nc(Cc4ccccc4)oc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL4870108 | 192767 | 0 | None | 36 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 334 | 5 | 1 | 3 | 4.0 | CC(=O)NCCC1CCc2ccc3nc(Cc4ccccc4)oc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm970437q | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm970437q | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm970437q | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm970437q | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm970437q | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm970437q | |||
9817262 | 26256 | 0 | None | 1 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 283 | 4 | 1 | 2 | 3.4 | CCC(=O)NCC1CCc2c(OC)ccc3cccc1c23 | 10.1021/jm000922c | |||
CHEMBL129889 | 26256 | 0 | None | 1 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 283 | 4 | 1 | 2 | 3.4 | CCC(=O)NCC1CCc2c(OC)ccc3cccc1c23 | 10.1021/jm000922c | |||
44272410 | 74791 | 0 | None | 7 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 274 | 5 | 2 | 3 | 2.9 | CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL19128 | 74791 | 0 | None | 7 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 274 | 5 | 2 | 3 | 2.9 | CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1 | 10.1016/j.bmcl.2003.12.052 | |||
23725565 | 132624 | 0 | None | -1 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 258 | 3 | 1 | 3 | 2.7 | CC(=O)NCCC1CCc2ccc3nc(C)oc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL3648355 | 132624 | 0 | None | -1 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 258 | 3 | 1 | 3 | 2.7 | CC(=O)NCCC1CCc2ccc3nc(C)oc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2020.112090 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2020.112090 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2020.112090 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2020.112090 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2020.112090 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2020.112090 | |||
44272317 | 105689 | 0 | None | 1 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 300 | 6 | 2 | 3 | 3.2 | CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL279343 | 105689 | 0 | None | 1 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 300 | 6 | 2 | 3 | 3.2 | CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1 | 10.1016/j.bmcl.2003.12.052 | |||
53310841 | 70571 | 0 | None | -5 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 299 | 5 | 1 | 4 | 2.2 | CCC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3 | 10.1021/jm200385u | |||
CHEMBL1802028 | 70571 | 0 | None | -5 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 299 | 5 | 1 | 4 | 2.2 | CCC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3 | 10.1021/jm200385u | |||
127042142 | 144853 | 0 | None | -3 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 310 | 5 | 1 | 4 | 3.2 | COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
CHEMBL3765540 | 144853 | 0 | None | -3 | 2 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 310 | 5 | 1 | 4 | 3.2 | COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
9926304 | 123353 | 0 | None | -9 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 299 | 4 | 1 | 3 | 3.0 | COc1ccc2ccc(OC)c3c2c1CCC3CNC(C)=O | 10.1021/jm000922c | |||
CHEMBL336509 | 123353 | 0 | None | -9 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 299 | 4 | 1 | 3 | 3.0 | COc1ccc2ccc(OC)c3c2c1CCC3CNC(C)=O | 10.1021/jm000922c | |||
115348 | 6858 | 47 | None | -4 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 10.1016/S0960-894X(97)00444-7 | |||
1343 | 6858 | 47 | None | -4 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 10.1016/S0960-894X(97)00444-7 | |||
CHEMBL289233 | 6858 | 47 | None | -4 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 10.1016/S0960-894X(97)00444-7 | |||
DB08190 | 6858 | 47 | None | -4 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 10.1016/S0960-894X(97)00444-7 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2015.09.003 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2015.09.003 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2015.09.003 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2015.09.003 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2015.09.003 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2015.09.003 | |||
57781246 | 132635 | 0 | None | 2 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 284 | 4 | 1 | 3 | 3.3 | CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL3648366 | 132635 | 0 | None | 2 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 284 | 4 | 1 | 3 | 3.3 | CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
23725612 | 132636 | 0 | None | 2 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 274 | 4 | 1 | 4 | 2.4 | COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL3648367 | 132636 | 0 | None | 2 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 274 | 4 | 1 | 4 | 2.4 | COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3 | 10.1021/acs.jmedchem.0c01836 | |||
9796846 | 123214 | 0 | None | -12 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 313 | 5 | 1 | 3 | 3.4 | CCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
CHEMBL336054 | 123214 | 0 | None | -12 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 313 | 5 | 1 | 3 | 3.4 | CCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
10522674 | 214540 | 0 | None | 56 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 362 | 7 | 1 | 3 | 4.5 | CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)Cc1ccccc1-2 | 10.1021/jm980684+ | |||
CHEMBL9590 | 214540 | 0 | None | 56 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 362 | 7 | 1 | 3 | 4.5 | CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)Cc1ccccc1-2 | 10.1021/jm980684+ | |||
10244841 | 74269 | 1 | None | 8 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 309 | 4 | 1 | 2 | 3.5 | CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21 | 10.1021/jm800974d | |||
CHEMBL189414 | 74269 | 1 | None | 8 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 309 | 4 | 1 | 2 | 3.5 | CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21 | 10.1021/jm800974d | |||
23725515 | 132634 | 0 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 272 | 4 | 1 | 3 | 2.9 | CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL3648365 | 132634 | 0 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 272 | 4 | 1 | 3 | 2.9 | CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3 | 10.1021/acs.jmedchem.0c01836 | |||
115348 | 6858 | 47 | None | -4 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 10.1021/jm011053+ | |||
1343 | 6858 | 47 | None | -4 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 10.1021/jm011053+ | |||
CHEMBL289233 | 6858 | 47 | None | -4 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 10.1021/jm011053+ | |||
DB08190 | 6858 | 47 | None | -4 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 10.1021/jm011053+ | |||
10244841 | 74269 | 1 | None | 8 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 309 | 4 | 1 | 2 | 3.5 | CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21 | 10.1021/jm040768k | |||
CHEMBL189414 | 74269 | 1 | None | 8 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 309 | 4 | 1 | 2 | 3.5 | CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21 | 10.1021/jm040768k | |||
44264892 | 211959 | 0 | None | 5 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 284 | 5 | 1 | 3 | 3.8 | CCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7832 | 211959 | 0 | None | 5 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 284 | 5 | 1 | 3 | 3.8 | CCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
9840647 | 104997 | 0 | None | 25 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 334 | 5 | 1 | 3 | 3.7 | CCC(=O)NCCc1c2n(c3ccc(OC)cc13)Cc1ccccc1-2 | 10.1021/jm980684+ | |||
CHEMBL274317 | 104997 | 0 | None | 25 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 334 | 5 | 1 | 3 | 3.7 | CCC(=O)NCCc1c2n(c3ccc(OC)cc13)Cc1ccccc1-2 | 10.1021/jm980684+ | |||
11079938 | 200636 | 4 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 403 | 5 | 2 | 4 | 2.4 | COc1cc2c(CCNC(C)=O)c(I)[nH]c2cc1[N+](=O)[O-] | 10.1021/jm011053+ | |||
CHEMBL52755 | 200636 | 4 | None | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 403 | 5 | 2 | 4 | 2.4 | COc1cc2c(CCNC(C)=O)c(I)[nH]c2cc1[N+](=O)[O-] | 10.1021/jm011053+ | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.2c00717 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.2c00717 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.2c00717 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.2c00717 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.2c00717 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.2c00717 | |||
9916005 | 39486 | 0 | None | -3 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 568 | 17 | 2 | 4 | 7.1 | CC(=O)NCCc1cccc2ccc(OCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 | 10.1021/jm0255872 | |||
CHEMBL14136 | 39486 | 0 | None | -3 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 568 | 17 | 2 | 4 | 7.1 | CC(=O)NCCc1cccc2ccc(OCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 | 10.1021/jm0255872 | |||
44353165 | 123692 | 0 | None | 7 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 267 | 4 | 1 | 1 | 3.8 | CCCC(=O)NCC1CCc2cccc3cccc1c23 | 10.1021/jm000922c | |||
CHEMBL338425 | 123692 | 0 | None | 7 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 267 | 4 | 1 | 1 | 3.8 | CCCC(=O)NCC1CCc2cccc3cccc1c23 | 10.1021/jm000922c | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
9798080 | 26257 | 0 | None | -3 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 341 | 7 | 1 | 3 | 4.2 | CCCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
CHEMBL129890 | 26257 | 0 | None | -3 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 341 | 7 | 1 | 3 | 4.2 | CCCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
15453821 | 211884 | 0 | None | 151 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 301 | 6 | 1 | 3 | 4.6 | CCCC(=O)Nc1ccc(Sc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7771 | 211884 | 0 | None | 151 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 301 | 6 | 1 | 3 | 4.6 | CCCC(=O)Nc1ccc(Sc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
10016733 | 85574 | 0 | None | -3 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 284 | 5 | 1 | 3 | 3.0 | CCc1nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2o1 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL2112724 | 85574 | 0 | None | -3 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 284 | 5 | 1 | 3 | 3.0 | CCc1nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2o1 | 10.1016/j.bmcl.2003.12.052 | |||
56653119 | 178571 | 0 | None | -1 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 322 | 7 | 2 | 2 | 3.5 | CC(=O)NCCc1c[nH]c2ccc(OCCc3ccccc3)cc12 | 10.1016/j.ejmech.2019.111847 | |||
CHEMBL4467954 | 178571 | 0 | None | -1 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 322 | 7 | 2 | 2 | 3.5 | CC(=O)NCCc1c[nH]c2ccc(OCCc3ccccc3)cc12 | 10.1016/j.ejmech.2019.111847 | |||
53310839 | 70568 | 0 | None | -2 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 273 | 4 | 1 | 4 | 1.6 | CCC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3 | 10.1021/jm200385u | |||
CHEMBL1802024 | 70568 | 0 | None | -2 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 273 | 4 | 1 | 4 | 1.6 | CCC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3 | 10.1021/jm200385u | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0201159 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0201159 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0201159 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0201159 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0201159 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0201159 | |||
24750191 | 95327 | 0 | None | 85 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 332 | 5 | 1 | 2 | 3.7 | CC(=O)NCCN(c1ccccc1)c1cccc(Br)c1 | 10.1021/jm700957j | |||
CHEMBL235328 | 95327 | 0 | None | 85 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 332 | 5 | 1 | 2 | 3.7 | CC(=O)NCCN(c1ccccc1)c1cccc(Br)c1 | 10.1021/jm700957j | |||
11810280 | 214710 | 0 | None | 16 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 351 | 8 | 1 | 3 | 4.5 | CCCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
CHEMBL96859 | 214710 | 0 | None | 16 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 351 | 8 | 1 | 3 | 4.5 | CCCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
1346 | 6948 | 47 | None | 25 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 266 | 4 | 2 | 2 | 2.5 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl | 10.1016/j.ejmech.2019.111847 | |||
1858 | 6948 | 47 | None | 25 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 266 | 4 | 2 | 2 | 2.5 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl | 10.1016/j.ejmech.2019.111847 | |||
CHEMBL34730 | 6948 | 47 | None | 25 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 266 | 4 | 2 | 2 | 2.5 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl | 10.1016/j.ejmech.2019.111847 | |||
10522675 | 11110 | 0 | None | 20 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 362 | 6 | 1 | 3 | 4.3 | CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2 | 10.1021/jm980684+ | |||
CHEMBL10099 | 11110 | 0 | None | 20 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 362 | 6 | 1 | 3 | 4.3 | CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2 | 10.1021/jm980684+ | |||
10522675 | 11110 | 0 | None | 20 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 362 | 6 | 1 | 3 | 4.3 | CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2 | 10.1016/j.ejmech.2019.111847 | |||
CHEMBL10099 | 11110 | 0 | None | 20 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 362 | 6 | 1 | 3 | 4.3 | CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2 | 10.1016/j.ejmech.2019.111847 | |||
198 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2017.10.025 | |||
82148 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2017.10.025 | |||
99 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL10878 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2017.10.025 | |||
DB06594 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2017.10.025 | |||
145982333 | 173336 | 0 | None | -1 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 284 | 3 | 2 | 2 | 2.8 | CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4279639 | 173336 | 0 | None | -1 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 284 | 3 | 2 | 2 | 2.8 | CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
145979689 | 173402 | 0 | None | 5 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 314 | 3 | 2 | 2 | 3.1 | CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4280791 | 173402 | 0 | None | 5 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 314 | 3 | 2 | 2 | 3.1 | CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
145981769 | 173446 | 0 | None | 1 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 270 | 3 | 1 | 3 | 2.4 | COc1ccc2ccc3c(c2n1)C(CNC(C)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4281712 | 173446 | 0 | None | 1 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 270 | 3 | 1 | 3 | 2.4 | COc1ccc2ccc3c(c2n1)C(CNC(C)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | |||
145993214 | 173530 | 0 | None | 5 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 285 | 3 | 2 | 3 | 2.2 | CNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4283539 | 173530 | 0 | None | 5 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 285 | 3 | 2 | 3 | 2.2 | CNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
145993188 | 173801 | 0 | None | 3 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 319 | 4 | 1 | 3 | 2.6 | COc1ccc2ccc3c(c2c1)C(C)(CNS(C)(=O)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4288497 | 173801 | 0 | None | 3 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 319 | 4 | 1 | 3 | 2.6 | COc1ccc2ccc3c(c2c1)C(C)(CNS(C)(=O)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | |||
145988269 | 173969 | 0 | None | 10 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 326 | 5 | 2 | 2 | 3.8 | CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4291381 | 173969 | 0 | None | 10 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 326 | 5 | 2 | 2 | 3.8 | CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
145986532 | 174060 | 0 | None | 1 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 269 | 3 | 1 | 2 | 3.0 | COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4293386 | 174060 | 0 | None | 1 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 269 | 3 | 1 | 2 | 3.0 | COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | |||
145993566 | 174150 | 0 | None | 25 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 312 | 5 | 2 | 2 | 3.6 | CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4294790 | 174150 | 0 | None | 25 | 3 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 312 | 5 | 2 | 2 | 3.6 | CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
198 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2016.12.013 | |||
82148 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2016.12.013 | |||
99 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL10878 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2016.12.013 | |||
DB06594 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2016.12.013 | |||
137639112 | 163631 | 0 | None | 10 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 245 | 4 | 2 | 3 | 1.5 | COc1ccc2cccc(CCNC(N)=O)c2n1 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4071572 | 163631 | 0 | None | 10 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 245 | 4 | 2 | 3 | 1.5 | COc1ccc2cccc(CCNC(N)=O)c2n1 | 10.1016/j.ejmech.2016.12.013 | |||
137660333 | 166299 | 0 | None | 1 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 244 | 4 | 1 | 3 | 1.9 | COc1ccc2cccc(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4102177 | 166299 | 0 | None | 1 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 244 | 4 | 1 | 3 | 1.9 | COc1ccc2cccc(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.12.013 | |||
56659223 | 71763 | 0 | None | -5 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 309 | 5 | 2 | 3 | 2.9 | COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2011.06.030 | |||
CHEMBL1823015 | 71763 | 0 | None | -5 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 309 | 5 | 2 | 3 | 2.9 | COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2011.06.030 | |||
1346 | 6948 | 47 | None | 25 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 266 | 4 | 2 | 2 | 2.5 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl | 10.1021/jm401343c | |||
1858 | 6948 | 47 | None | 25 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 266 | 4 | 2 | 2 | 2.5 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl | 10.1021/jm401343c | |||
CHEMBL34730 | 6948 | 47 | None | 25 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 266 | 4 | 2 | 2 | 2.5 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl | 10.1021/jm401343c | |||
15453090 | 93187 | 0 | None | -3 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 285 | 4 | 1 | 3 | 2.8 | COc1ccc2ccc(OC)c([C@@H]3C[C@H]3NC(C)=O)c2c1 | 10.1016/j.bmcl.2012.11.069 | |||
CHEMBL2314253 | 93187 | 0 | None | -3 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 285 | 4 | 1 | 3 | 2.8 | COc1ccc2ccc(OC)c([C@@H]3C[C@H]3NC(C)=O)c2c1 | 10.1016/j.bmcl.2012.11.069 | |||
11110447 | 214568 | 0 | None | 4 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 335 | 6 | 1 | 3 | 4.3 | C/C=C/C(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
CHEMBL96104 | 214568 | 0 | None | 4 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 335 | 6 | 1 | 3 | 4.3 | C/C=C/C(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
10854190 | 105089 | 0 | None | 87 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 334 | 5 | 1 | 3 | 3.7 | CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1 | 10.1021/jm980684+ | |||
CHEMBL274896 | 105089 | 0 | None | 87 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 334 | 5 | 1 | 3 | 3.7 | CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1 | 10.1021/jm980684+ | |||
198 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2015.12.047 | |||
82148 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2015.12.047 | |||
99 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL10878 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2015.12.047 | |||
DB06594 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2015.12.047 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200385u | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200385u | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200385u | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200385u | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200385u | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200385u | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c01836 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c01836 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c01836 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c01836 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.0c01836 | |||
198 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2020.112078 | |||
82148 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2020.112078 | |||
99 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2020.112078 | |||
CHEMBL10878 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2020.112078 | |||
DB06594 | 7101 | 126 | None | 1 | 6 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.ejmech.2020.112078 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200221q | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200221q | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200221q | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200221q | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200221q | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm200221q | |||
16094584 | 90020 | 0 | None | 33 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 281 | 5 | 1 | 2 | 3.3 | COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1 | 10.1021/jm060850a | |||
CHEMBL218708 | 90020 | 0 | None | 33 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 281 | 5 | 1 | 2 | 3.3 | COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1 | 10.1021/jm060850a | |||
10752506 | 26758 | 0 | None | 5 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 239 | 2 | 1 | 1 | 3.0 | CC(=O)NCC1CCc2cccc3cccc1c23 | 10.1021/jm000922c | |||
CHEMBL130319 | 26758 | 0 | None | 5 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 239 | 2 | 1 | 1 | 3.0 | CC(=O)NCC1CCc2cccc3cccc1c23 | 10.1021/jm000922c | |||
10561982 | 29794 | 0 | None | 12 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 239 | 3 | 1 | 1 | 3.0 | CCC(=O)NCC1Cc2cccc3cccc1c23 | 10.1021/jm000922c | |||
CHEMBL133001 | 29794 | 0 | None | 12 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 239 | 3 | 1 | 1 | 3.0 | CCC(=O)NCC1Cc2cccc3cccc1c23 | 10.1021/jm000922c | |||
11002840 | 214306 | 0 | None | 33 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 357 | 6 | 1 | 3 | 4.4 | COc1ccc2oc(Cc3cccc(Cl)c3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
CHEMBL94607 | 214306 | 0 | None | 33 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 357 | 6 | 1 | 3 | 4.4 | COc1ccc2oc(Cc3cccc(Cl)c3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
137648419 | 164618 | 0 | None | 15 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 293 | 4 | 1 | 1 | 3.9 | CCC(=O)NC[C@@H]1CCc2ccccc2[C@@H]1c1ccccc1 | 10.1021/acs.jmedchem.8b00359 | |||
CHEMBL4083618 | 164618 | 0 | None | 15 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 293 | 4 | 1 | 1 | 3.9 | CCC(=O)NC[C@@H]1CCc2ccccc2[C@@H]1c1ccccc1 | 10.1021/acs.jmedchem.8b00359 | |||
24954990 | 70569 | 0 | None | -5 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 287 | 5 | 1 | 4 | 1.9 | CCC(=O)NCCc1c(CC)nn2ccc3c(c12)CCO3 | 10.1021/jm200385u | |||
CHEMBL1802026 | 70569 | 0 | None | -5 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 287 | 5 | 1 | 4 | 1.9 | CCC(=O)NCCc1c(CC)nn2ccc3c(c12)CCO3 | 10.1021/jm200385u | |||
115348 | 6858 | 47 | None | -4 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 10.1021/jm401343c | |||
1343 | 6858 | 47 | None | -4 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 10.1021/jm401343c | |||
CHEMBL289233 | 6858 | 47 | None | -4 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 10.1021/jm401343c | |||
DB08190 | 6858 | 47 | None | -4 | 2 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 10.1021/jm401343c | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/S0960-894X(97)00392-2 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/S0960-894X(97)00392-2 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/S0960-894X(97)00392-2 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/S0960-894X(97)00392-2 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/S0960-894X(97)00392-2 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/S0960-894X(97)00392-2 | |||
9884406 | 214405 | 0 | None | 3 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 341 | 6 | 1 | 3 | 3.9 | COc1ccc2oc(Cc3cccc(F)c3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
CHEMBL95166 | 214405 | 0 | None | 3 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 341 | 6 | 1 | 3 | 3.9 | COc1ccc2oc(Cc3cccc(F)c3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
44264903 | 212397 | 0 | None | -4 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 270 | 4 | 1 | 3 | 3.4 | COc1cccc(N(C)c2ccc(NC(C)=O)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL8168 | 212397 | 0 | None | -4 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 270 | 4 | 1 | 3 | 3.4 | COc1cccc(N(C)c2ccc(NC(C)=O)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
137637541 | 162777 | 0 | None | 269 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 293 | 4 | 1 | 1 | 3.9 | CCC(=O)NC[C@@H]1CCc2ccccc2[C@H]1c1ccccc1 | 10.1021/acs.jmedchem.8b00359 | |||
CHEMBL4061850 | 162777 | 0 | None | 269 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 293 | 4 | 1 | 1 | 3.9 | CCC(=O)NC[C@@H]1CCc2ccccc2[C@H]1c1ccccc1 | 10.1021/acs.jmedchem.8b00359 | |||
57781208 | 192400 | 0 | None | 5 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 320 | 4 | 1 | 3 | 4.1 | CC(=O)NCCC1CCc2ccc3nc(-c4ccccc4)oc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL4864102 | 192400 | 0 | None | 5 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 320 | 4 | 1 | 3 | 4.1 | CC(=O)NCCC1CCc2ccc3nc(-c4ccccc4)oc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm700957j | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm700957j | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm700957j | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm700957j | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm700957j | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm700957j | |||
10540964 | 123406 | 0 | None | -1 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 283 | 5 | 1 | 2 | 3.4 | CCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
CHEMBL336858 | 123406 | 0 | None | -1 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 283 | 5 | 1 | 2 | 3.4 | CCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
44272316 | 74374 | 0 | None | -4 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 392 | 10 | 2 | 3 | 5.3 | CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL19026 | 74374 | 0 | None | -4 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 392 | 10 | 2 | 3 | 5.3 | CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2 | 10.1016/j.bmcl.2003.12.052 | |||
139451781 | 191637 | 0 | None | 1 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 289 | 5 | 1 | 5 | 1.5 | CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3 | 10.1021/acs.jmedchem.0c00627 | |||
CHEMBL4852440 | 191637 | 0 | None | 1 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 289 | 5 | 1 | 5 | 1.5 | CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3 | 10.1021/acs.jmedchem.0c00627 | |||
52953165 | 69182 | 0 | None | 218 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 389 | 7 | 1 | 3 | 5.6 | C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | |||
CHEMBL1779810 | 69182 | 0 | None | 218 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 389 | 7 | 1 | 3 | 5.6 | C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | |||
10019103 | 74267 | 0 | None | 5 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 323 | 5 | 1 | 2 | 3.8 | CCCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21 | 10.1021/jm040768k | |||
CHEMBL189395 | 74267 | 0 | None | 5 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 323 | 5 | 1 | 2 | 3.8 | CCCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21 | 10.1021/jm040768k | |||
129776 | 6930 | 6 | None | 128 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 322 | 6 | 2 | 2 | 3.4 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1 | 10.1016/j.ejmech.2019.111847 | |||
1364 | 6930 | 6 | None | 128 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 322 | 6 | 2 | 2 | 3.4 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1 | 10.1016/j.ejmech.2019.111847 | |||
CHEMBL339105 | 6930 | 6 | None | 128 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 322 | 6 | 2 | 2 | 3.4 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1 | 10.1016/j.ejmech.2019.111847 | |||
1353 | 10208 | 5 | None | 112 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC | 10.1021/jm800974d | |||
9998187 | 10208 | 5 | None | 112 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC | 10.1021/jm800974d | |||
CHEMBL33549 | 10208 | 5 | None | 112 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC | 10.1021/jm800974d | |||
129776 | 6930 | 6 | None | 128 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 322 | 6 | 2 | 2 | 3.4 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1 | 10.1021/jm401343c | |||
1364 | 6930 | 6 | None | 128 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 322 | 6 | 2 | 2 | 3.4 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1 | 10.1021/jm401343c | |||
CHEMBL339105 | 6930 | 6 | None | 128 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 322 | 6 | 2 | 2 | 3.4 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1 | 10.1021/jm401343c | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm060850a | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm060850a | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm060850a | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm060850a | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm060850a | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm060850a | |||
9840277 | 30335 | 0 | None | -10 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 325 | 5 | 1 | 3 | 3.4 | COc1ccc2ccc(OC)c3c2c1CCC3CNC(=O)C1CC1 | 10.1021/jm000922c | |||
CHEMBL133416 | 30335 | 0 | None | -10 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 325 | 5 | 1 | 3 | 3.4 | COc1ccc2ccc(OC)c3c2c1CCC3CNC(=O)C1CC1 | 10.1021/jm000922c | |||
10617720 | 214598 | 0 | None | 56 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 348 | 6 | 1 | 3 | 4.1 | CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2Cc2ccccc2-1 | 10.1021/jm980684+ | |||
CHEMBL9630 | 214598 | 0 | None | 56 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 348 | 6 | 1 | 3 | 4.1 | CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2Cc2ccccc2-1 | 10.1021/jm980684+ | |||
198 | 7101 | 126 | None | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1021/jm0255872 | |||
82148 | 7101 | 126 | None | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1021/jm0255872 | |||
99 | 7101 | 126 | None | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1021/jm0255872 | |||
CHEMBL10878 | 7101 | 126 | None | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1021/jm0255872 | |||
DB06594 | 7101 | 126 | None | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1021/jm0255872 | |||
198 | 7101 | 126 | None | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmc.2008.08.052 | |||
82148 | 7101 | 126 | None | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmc.2008.08.052 | |||
99 | 7101 | 126 | None | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL10878 | 7101 | 126 | None | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmc.2008.08.052 | |||
DB06594 | 7101 | 126 | None | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1016/j.bmc.2008.08.052 | |||
1354 | 10209 | 15 | None | 275 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 334 | 5 | 2 | 3 | 3.8 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N | 10.1016/j.bmc.2008.08.052 | |||
22133318 | 10209 | 15 | None | 275 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 334 | 5 | 2 | 3 | 3.8 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL490188 | 10209 | 15 | None | 275 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 334 | 5 | 2 | 3 | 3.8 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N | 10.1016/j.bmc.2008.08.052 | |||
11644612 | 85073 | 0 | None | 9 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 260 | 4 | 1 | 3 | 2.4 | COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C | 10.1021/jm0512544 | |||
CHEMBL210791 | 85073 | 0 | None | 9 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 260 | 4 | 1 | 3 | 2.4 | COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C | 10.1021/jm0512544 | |||
16094586 | 89923 | 4 | None | 213 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 311 | 6 | 1 | 3 | 3.3 | COc1cccc(C(=CCNC(C)=O)c2cccc(OC)c2)c1 | 10.1021/jm060850a | |||
CHEMBL218225 | 89923 | 4 | None | 213 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 311 | 6 | 1 | 3 | 3.3 | COc1cccc(C(=CCNC(C)=O)c2cccc(OC)c2)c1 | 10.1021/jm060850a | |||
44272334 | 74409 | 0 | None | 17 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 302 | 6 | 2 | 3 | 3.5 | CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL19050 | 74409 | 0 | None | 17 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 302 | 6 | 2 | 3 | 3.5 | CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1 | 10.1016/j.bmcl.2003.12.052 | |||
139451763 | 193112 | 0 | None | 1 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 305 | 8 | 1 | 5 | 2.4 | CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21 | 10.1021/acs.jmedchem.0c00627 | |||
CHEMBL4874954 | 193112 | 0 | None | 1 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 305 | 8 | 1 | 5 | 2.4 | CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21 | 10.1021/acs.jmedchem.0c00627 | |||
52918078 | 67528 | 0 | None | 11 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 247 | 5 | 1 | 4 | 1.6 | CCC(=O)NCCn1ccc2ccc(OC)nc21 | 10.1016/j.bmcl.2011.02.097 | |||
CHEMBL1760946 | 67528 | 0 | None | 11 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 247 | 5 | 1 | 4 | 1.6 | CCC(=O)NCCn1ccc2ccc(OC)nc21 | 10.1016/j.bmcl.2011.02.097 | |||
53310840 | 70570 | 0 | None | -6 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 285 | 4 | 1 | 4 | 1.8 | CC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3 | 10.1021/jm200385u | |||
CHEMBL1802027 | 70570 | 0 | None | -6 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 285 | 4 | 1 | 4 | 1.8 | CC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3 | 10.1021/jm200385u | |||
12985495 | 188165 | 0 | None | 213 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 377 | 8 | 2 | 3 | 4.5 | CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL476341 | 188165 | 0 | None | 213 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 377 | 8 | 2 | 3 | 4.5 | CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 | 10.1016/j.bmc.2008.08.052 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm040768k | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm040768k | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm040768k | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm040768k | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm040768k | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm040768k | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm001125h | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm001125h | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm001125h | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm001125h | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm001125h | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm001125h | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm048956y | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm048956y | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm048956y | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm048956y | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm048956y | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm048956y | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.8b00893 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.8b00893 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.8b00893 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.8b00893 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.8b00893 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/acs.jmedchem.8b00893 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/S0960-894X(97)00444-7 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/S0960-894X(97)00444-7 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/S0960-894X(97)00444-7 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/S0960-894X(97)00444-7 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/S0960-894X(97)00444-7 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/S0960-894X(97)00444-7 | |||
46865422 | 93846 | 0 | None | 575 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 357 | 10 | 1 | 4 | 3.7 | CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1 | 10.1016/j.bmc.2012.10.060 | |||
CHEMBL2326199 | 93846 | 0 | None | 575 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 357 | 10 | 1 | 4 | 3.7 | CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1 | 10.1016/j.bmc.2012.10.060 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm020982d | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm020982d | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm020982d | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm020982d | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm020982d | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm020982d | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2003.09.030 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2003.09.030 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2003.09.030 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2003.09.030 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2003.09.030 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2004.04.082 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2004.04.082 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2004.04.082 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2004.04.082 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2004.04.082 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2003.12.052 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2003.12.052 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2003.12.052 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2003.12.052 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2003.12.052 | |||
137641357 | 163858 | 0 | None | 3 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 280 | 3 | 1 | 2 | 3.1 | CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | |||
CHEMBL4074273 | 163858 | 0 | None | 3 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 280 | 3 | 1 | 2 | 3.1 | CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | |||
21581654 | 67526 | 1 | None | -1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 233 | 4 | 2 | 3 | 1.3 | COc1ccc2[nH]cc(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | |||
CHEMBL1760944 | 67526 | 1 | None | -1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 233 | 4 | 2 | 3 | 1.3 | COc1ccc2[nH]cc(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | |||
52918079 | 67529 | 0 | None | 4 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 261 | 6 | 1 | 4 | 2.0 | CCCC(=O)NCCn1ccc2ccc(OC)nc21 | 10.1016/j.bmcl.2011.02.097 | |||
CHEMBL1760947 | 67529 | 0 | None | 4 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 261 | 6 | 1 | 4 | 2.0 | CCCC(=O)NCCn1ccc2ccc(OC)nc21 | 10.1016/j.bmcl.2011.02.097 | |||
145979282 | 173454 | 0 | None | 16 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 300 | 3 | 2 | 2 | 3.0 | CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4281915 | 173454 | 0 | None | 16 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 300 | 3 | 2 | 2 | 3.0 | CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
145992795 | 173570 | 0 | None | 29 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 342 | 5 | 2 | 2 | 3.9 | CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4284223 | 173570 | 0 | None | 29 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 342 | 5 | 2 | 2 | 3.9 | CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
145990662 | 173708 | 0 | None | 2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 312 | 4 | 2 | 2 | 3.4 | CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4286896 | 173708 | 0 | None | 2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 312 | 4 | 2 | 2 | 3.4 | CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
137636173 | 162780 | 0 | None | 63 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 276 | 6 | 1 | 3 | 2.3 | COc1ccc2cccc(CCC(=O)NCCF)c2n1 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4061905 | 162780 | 0 | None | 63 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 276 | 6 | 1 | 3 | 2.3 | COc1ccc2cccc(CCC(=O)NCCF)c2n1 | 10.1016/j.ejmech.2016.12.013 | |||
137650611 | 164291 | 0 | None | 26 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 244 | 4 | 1 | 3 | 1.9 | CNC(=O)CCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4079784 | 164291 | 0 | None | 26 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 244 | 4 | 1 | 3 | 1.9 | CNC(=O)CCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | |||
137645530 | 164502 | 0 | None | 23 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 260 | 4 | 1 | 4 | 2.1 | COC(=O)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4082097 | 164502 | 0 | None | 23 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 260 | 4 | 1 | 4 | 2.1 | COC(=O)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2007.03.080 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2007.03.080 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2007.03.080 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2007.03.080 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2007.03.080 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2007.03.080 | |||
71540396 | 93192 | 0 | None | -1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 286 | 4 | 2 | 3 | 2.8 | CNC(=O)N/C=C/c1c(OC)ccc2ccc(OC)cc12 | 10.1016/j.bmcl.2012.11.069 | |||
CHEMBL2314260 | 93192 | 0 | None | -1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 286 | 4 | 2 | 3 | 2.8 | CNC(=O)N/C=C/c1c(OC)ccc2ccc(OC)cc12 | 10.1016/j.bmcl.2012.11.069 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
44358146 | 33850 | 0 | None | -2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 274 | 4 | 1 | 3 | 2.1 | CCCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL136531 | 33850 | 0 | None | -2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 274 | 4 | 1 | 3 | 2.1 | CCCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
10850411 | 122135 | 0 | None | 4 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 281 | 4 | 1 | 2 | 3.0 | COc1ccc2cccc3c2c1C(CNC(=O)C1CC1)C3 | 10.1021/jm000922c | |||
CHEMBL334962 | 122135 | 0 | None | 4 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 281 | 4 | 1 | 2 | 3.0 | COc1ccc2cccc3c2c1C(CNC(=O)C1CC1)C3 | 10.1021/jm000922c | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0005252 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0005252 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0005252 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0005252 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0005252 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0005252 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2016.12.013 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2016.12.013 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2016.12.013 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2016.12.013 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2016.12.013 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm011053+ | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm011053+ | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm011053+ | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm011053+ | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm011053+ | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm011053+ | |||
23658146 | 163897 | 1 | None | 10 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 287 | 6 | 2 | 3 | 2.5 | CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12 | 10.1039/C4MD00149D | |||
CHEMBL4074895 | 163897 | 1 | None | 10 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 287 | 6 | 2 | 3 | 2.5 | CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12 | 10.1039/C4MD00149D | |||
1353 | 10208 | 5 | None | 112 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC | 10.1021/jm0005252 | |||
9998187 | 10208 | 5 | None | 112 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC | 10.1021/jm0005252 | |||
CHEMBL33549 | 10208 | 5 | None | 112 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC | 10.1021/jm0005252 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2003.11.030 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2003.11.030 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2003.11.030 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2003.11.030 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2003.11.030 | |||
44272430 | 173711 | 0 | None | 15 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 288 | 5 | 2 | 3 | 3.1 | CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL428692 | 173711 | 0 | None | 15 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 288 | 5 | 2 | 3 | 3.1 | CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 | 10.1016/j.bmcl.2003.12.052 | |||
1353 | 10208 | 5 | None | 112 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC | 10.1021/jm048956y | |||
9998187 | 10208 | 5 | None | 112 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC | 10.1021/jm048956y | |||
CHEMBL33549 | 10208 | 5 | None | 112 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC | 10.1021/jm048956y | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm980684+ | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm980684+ | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm980684+ | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm980684+ | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm980684+ | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm980684+ | |||
10446712 | 85573 | 0 | None | -6 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 286 | 6 | 1 | 3 | 3.4 | CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL2112722 | 85573 | 0 | None | -6 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 286 | 6 | 1 | 3 | 3.4 | CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12 | 10.1016/j.bmcl.2003.12.052 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
53310987 | 70573 | 0 | None | -1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 327 | 4 | 1 | 4 | 2.4 | CCC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3 | 10.1021/jm200385u | |||
CHEMBL1802030 | 70573 | 0 | None | -1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 327 | 4 | 1 | 4 | 2.4 | CCC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3 | 10.1021/jm200385u | |||
1353 | 10208 | 5 | None | 112 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC | 10.1021/jm401343c | |||
9998187 | 10208 | 5 | None | 112 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC | 10.1021/jm401343c | |||
CHEMBL33549 | 10208 | 5 | None | 112 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC | 10.1021/jm401343c | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2011.06.063 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2011.06.063 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2011.06.063 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2011.06.063 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2011.06.063 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2011.06.063 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2007.04.013 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2007.04.013 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2007.04.013 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2007.04.013 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2007.04.013 | |||
71508235 | 93850 | 0 | None | 95 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 327 | 8 | 1 | 3 | 3.8 | CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1 | 10.1016/j.bmc.2012.10.060 | |||
CHEMBL2326203 | 93850 | 0 | None | 95 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 327 | 8 | 1 | 3 | 3.8 | CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1 | 10.1016/j.bmc.2012.10.060 | |||
10661735 | 175103 | 0 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 297 | 6 | 1 | 2 | 3.8 | CCCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
CHEMBL434226 | 175103 | 0 | None | 1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 297 | 6 | 1 | 2 | 3.8 | CCCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
10059864 | 116600 | 5 | None | -2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 233 | 4 | 1 | 3 | 2.1 | COc1ccc2occ(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
CHEMBL323332 | 116600 | 5 | None | -2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 233 | 4 | 1 | 3 | 2.1 | COc1ccc2occ(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
11824364 | 119329 | 0 | None | 42 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1ccc2oc(Cc3ccccc3OC)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
CHEMBL329960 | 119329 | 0 | None | 42 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1ccc2oc(Cc3ccccc3OC)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2011.02.097 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2011.02.097 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2011.02.097 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2011.02.097 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2011.02.097 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2011.02.097 | |||
10059864 | 116600 | 5 | None | -2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 233 | 4 | 1 | 3 | 2.1 | COc1ccc2occ(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL323332 | 116600 | 5 | None | -2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 233 | 4 | 1 | 3 | 2.1 | COc1ccc2occ(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2011.06.030 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2011.06.030 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2011.06.030 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2011.06.030 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2011.06.030 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2011.06.030 | |||
53238409 | 68801 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 377 | 6 | 1 | 3 | 4.4 | CC(=O)NCCC1=C(c2ccccc2OC(C)C)Cc2ccc3c(c21)CCO3 | 10.1021/jm200221q | |||
CHEMBL1774528 | 68801 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 377 | 6 | 1 | 3 | 4.4 | CC(=O)NCCC1=C(c2ccccc2OC(C)C)Cc2ccc3c(c21)CCO3 | 10.1021/jm200221q | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2016.01.008 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2016.01.008 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2016.01.008 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2016.01.008 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2016.01.008 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2016.01.008 | |||
10059864 | 116600 | 5 | None | -2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 233 | 4 | 1 | 3 | 2.1 | COc1ccc2occ(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2016.01.008 | |||
CHEMBL323332 | 116600 | 5 | None | -2 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 233 | 4 | 1 | 3 | 2.1 | COc1ccc2occ(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2016.01.008 | |||
122220128 | 166454 | 0 | None | 5 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 309 | 6 | 2 | 3 | 2.3 | COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1 | 10.1039/C4MD00149D | |||
CHEMBL4104020 | 166454 | 0 | None | 5 | 3 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 309 | 6 | 2 | 3 | 2.3 | COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1 | 10.1039/C4MD00149D | |||
18466111 | 26617 | 0 | None | -1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 283 | 5 | 1 | 2 | 3.4 | CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
CHEMBL130214 | 26617 | 0 | None | -1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 283 | 5 | 1 | 2 | 3.4 | CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
10882307 | 214253 | 0 | None | 15 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 338 | 6 | 2 | 3 | 3.5 | CNC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
CHEMBL94301 | 214253 | 0 | None | 15 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 338 | 6 | 2 | 3 | 3.5 | CNC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2011.02.044 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2011.02.044 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2011.02.044 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2011.02.044 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2011.02.044 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2011.02.044 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0512544 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0512544 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0512544 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0512544 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0512544 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0512544 | |||
25024912 | 192698 | 0 | None | -1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 271 | 4 | 1 | 3 | 2.5 | CCC(=O)NCCC1CCc2ccc3nn(C)cc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL4869029 | 192698 | 0 | None | -1 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 271 | 4 | 1 | 3 | 2.5 | CCC(=O)NCCC1CCc2ccc3nn(C)cc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
16750569 | 94137 | 0 | None | 14 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 338 | 6 | 2 | 2 | 3.4 | CCCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL233308 | 94137 | 0 | None | 14 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 338 | 6 | 2 | 2 | 3.4 | CCCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2007.01.005 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2007.01.005 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2007.01.005 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2007.01.005 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2007.01.005 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2007.01.005 | |||
7922 | 8737 | 0 | None | 741 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO | 10.1016/j.bmc.2008.08.052 | |||
9798456 | 8737 | 0 | None | 741 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL476131 | 8737 | 0 | None | 741 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO | 10.1016/j.bmc.2008.08.052 | |||
21581654 | 67526 | 1 | None | -1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 233 | 4 | 2 | 3 | 1.3 | COc1ccc2[nH]cc(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2011.06.030 | |||
CHEMBL1760944 | 67526 | 1 | None | -1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 233 | 4 | 2 | 3 | 1.3 | COc1ccc2[nH]cc(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2011.06.030 | |||
21581654 | 67526 | 1 | None | -1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 233 | 4 | 2 | 3 | 1.3 | COc1ccc2[nH]cc(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
CHEMBL1760944 | 67526 | 1 | None | -1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 233 | 4 | 2 | 3 | 1.3 | COc1ccc2[nH]cc(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
9998754 | 85569 | 0 | None | -7 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 362 | 8 | 1 | 3 | 4.6 | CC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL2112700 | 85569 | 0 | None | -7 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 362 | 8 | 1 | 3 | 4.6 | CC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12 | 10.1016/j.bmcl.2003.12.052 | |||
9818487 | 180312 | 0 | None | 141 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 319 | 5 | 1 | 2 | 4.2 | COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL453138 | 180312 | 0 | None | 141 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 319 | 5 | 1 | 2 | 4.2 | COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
139451764 | 193046 | 0 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 275 | 4 | 1 | 5 | 1.1 | COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3 | 10.1021/acs.jmedchem.0c00627 | |||
CHEMBL4873903 | 193046 | 0 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 275 | 4 | 1 | 5 | 1.1 | COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3 | 10.1021/acs.jmedchem.0c00627 | |||
10016919 | 107386 | 1 | None | -3 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 287 | 6 | 1 | 3 | 2.9 | CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12 | 10.1016/S0960-894X(97)00444-7 | |||
CHEMBL291857 | 107386 | 1 | None | -3 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 287 | 6 | 1 | 3 | 2.9 | CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12 | 10.1016/S0960-894X(97)00444-7 | |||
10016919 | 107386 | 1 | None | -3 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 287 | 6 | 1 | 3 | 2.9 | CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12 | 10.1021/jm970437q | |||
CHEMBL291857 | 107386 | 1 | None | -3 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 287 | 6 | 1 | 3 | 2.9 | CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12 | 10.1021/jm970437q | |||
198 | 7101 | 126 | None | 1 | 6 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1039/C4MD00149D | |||
82148 | 7101 | 126 | None | 1 | 6 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1039/C4MD00149D | |||
99 | 7101 | 126 | None | 1 | 6 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1039/C4MD00149D | |||
CHEMBL10878 | 7101 | 126 | None | 1 | 6 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1039/C4MD00149D | |||
DB06594 | 7101 | 126 | None | 1 | 6 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1039/C4MD00149D | |||
9925797 | 29024 | 0 | None | -3 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 283 | 4 | 1 | 2 | 3.4 | COc1ccc2cccc3c2c1C(CCNC(C)=O)CC3 | 10.1021/jm000922c | |||
CHEMBL132340 | 29024 | 0 | None | -3 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 283 | 4 | 1 | 2 | 3.4 | COc1ccc2cccc3c2c1C(CCNC(C)=O)CC3 | 10.1021/jm000922c | |||
44264705 | 211240 | 1 | None | 79 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 284 | 6 | 2 | 3 | 4.2 | CCCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7229 | 211240 | 1 | None | 79 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 284 | 6 | 2 | 3 | 4.2 | CCCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
44358196 | 126064 | 0 | None | -2 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 260 | 3 | 1 | 3 | 1.7 | CCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL343825 | 126064 | 0 | None | -2 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 260 | 3 | 1 | 3 | 1.7 | CCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
127026062 | 144467 | 0 | None | 5 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 269 | 3 | 1 | 3 | 3.2 | COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL3758717 | 144467 | 0 | None | 5 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 269 | 3 | 1 | 3 | 3.2 | COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
145979585 | 173269 | 0 | None | 17 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 313 | 5 | 2 | 3 | 3.0 | CCCNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4278446 | 173269 | 0 | None | 17 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 313 | 5 | 2 | 3 | 3.0 | CCCNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
145991966 | 173615 | 0 | None | 5 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 285 | 3 | 1 | 3 | 3.2 | COC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4285145 | 173615 | 0 | None | 5 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 285 | 3 | 1 | 3 | 3.2 | COC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
145991111 | 173691 | 0 | None | 17 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 319 | 5 | 1 | 3 | 2.8 | CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4286494 | 173691 | 0 | None | 17 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 319 | 5 | 1 | 3 | 2.8 | CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
145986330 | 173836 | 0 | None | 15 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 286 | 3 | 2 | 2 | 2.7 | COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4289115 | 173836 | 0 | None | 15 | 3 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 286 | 3 | 2 | 2 | 2.7 | COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3 | 10.1016/j.ejmech.2017.10.025 | |||
137650826 | 164284 | 0 | None | 10 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 289 | 5 | 2 | 3 | 2.3 | CCNC(=S)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4079699 | 164284 | 0 | None | 10 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 289 | 5 | 2 | 3 | 2.3 | CCNC(=S)NCCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | |||
10333442 | 210665 | 0 | None | 5 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 272 | 6 | 1 | 3 | 2.7 | CCCC(=O)NCCc1ccnc2ccc(OC)cc12 | 10.1016/S0960-894X(97)00392-2 | |||
CHEMBL68864 | 210665 | 0 | None | 5 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 272 | 6 | 1 | 3 | 2.7 | CCCC(=O)NCCc1ccnc2ccc(OC)cc12 | 10.1016/S0960-894X(97)00392-2 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0255872 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0255872 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0255872 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0255872 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0255872 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm0255872 | |||
10199282 | 123371 | 0 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 269 | 3 | 1 | 2 | 3.0 | COc1ccc2cccc3c2c1CCC3CNC(C)=O | 10.1021/jm000922c | |||
CHEMBL336647 | 123371 | 0 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 269 | 3 | 1 | 2 | 3.0 | COc1ccc2cccc3c2c1CCC3CNC(C)=O | 10.1021/jm000922c | |||
11733059 | 118431 | 0 | None | 21 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 449 | 7 | 1 | 3 | 4.1 | COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)CI)c2c1 | 10.1021/jm0005252 | |||
CHEMBL328617 | 118431 | 0 | None | 21 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 449 | 7 | 1 | 3 | 4.1 | COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)CI)c2c1 | 10.1021/jm0005252 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.08.052 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.08.052 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.08.052 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.08.052 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.08.052 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2014.09.038 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2014.09.038 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2014.09.038 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2014.09.038 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2014.09.038 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2014.09.038 | |||
11644612 | 85073 | 0 | None | 9 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 260 | 4 | 1 | 3 | 2.4 | COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C | 10.1021/jm0512544 | |||
CHEMBL210791 | 85073 | 0 | None | 9 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 260 | 4 | 1 | 3 | 2.4 | COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C | 10.1021/jm0512544 | |||
10468642 | 33891 | 0 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 275 | 3 | 2 | 3 | 1.5 | CCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL136564 | 33891 | 0 | None | 1 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 275 | 3 | 2 | 3 | 1.5 | CCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
24954989 | 8314 | 1 | None | -6 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 273 | 4 | 1 | 4 | 1.5 | CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2 | 10.1021/jm200385u | |||
7774 | 8314 | 1 | None | -6 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 273 | 4 | 1 | 4 | 1.5 | CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2 | 10.1021/jm200385u | |||
CHEMBL1802025 | 8314 | 1 | None | -6 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 273 | 4 | 1 | 4 | 1.5 | CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2 | 10.1021/jm200385u | |||
44579259 | 193893 | 0 | None | 331 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 347 | 6 | 1 | 3 | 4.0 | COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL491604 | 193893 | 0 | None | 331 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 347 | 6 | 1 | 3 | 4.0 | COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2012.10.060 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2012.10.060 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2012.10.060 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2012.10.060 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2012.10.060 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2012.10.060 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2010.02.084 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2010.02.084 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2010.02.084 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2010.02.084 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2010.02.084 | |||
10423378 | 85575 | 0 | None | -8 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 272 | 5 | 1 | 3 | 3.0 | CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL2112727 | 85575 | 0 | None | -8 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 272 | 5 | 1 | 3 | 3.0 | CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12 | 10.1016/j.bmcl.2003.12.052 | |||
198 | 7101 | 126 | None | 1 | 6 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1021/jm000922c | |||
82148 | 7101 | 126 | None | 1 | 6 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1021/jm000922c | |||
99 | 7101 | 126 | None | 1 | 6 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1021/jm000922c | |||
CHEMBL10878 | 7101 | 126 | None | 1 | 6 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1021/jm000922c | |||
DB06594 | 7101 | 126 | None | 1 | 6 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 10.1021/jm000922c | |||
86273228 | 128098 | 0 | None | 5 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 258 | 6 | 2 | 2 | 2.4 | C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12 | 10.1021/acs.jmedchem.5b00245 | |||
CHEMBL3580910 | 128098 | 0 | None | 5 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 258 | 6 | 2 | 2 | 2.4 | C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12 | 10.1021/acs.jmedchem.5b00245 | |||
1358 | 6912 | 41 | None | 870 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | 10.1021/jm800974d | |||
3976006 | 6912 | 41 | None | 870 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | 10.1021/jm800974d | |||
CHEMBL285718 | 6912 | 41 | None | 870 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | 10.1021/jm800974d | |||
11652196 | 145091 | 0 | None | 9 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 288 | 6 | 1 | 3 | 3.2 | CCCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12 | 10.1021/jm0512544 | |||
CHEMBL377101 | 145091 | 0 | None | 9 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 288 | 6 | 1 | 3 | 3.2 | CCCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12 | 10.1021/jm0512544 | |||
11741001 | 85579 | 0 | None | -9 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 388 | 9 | 1 | 3 | 5.0 | O=C(NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12)C1CC1 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL2112734 | 85579 | 0 | None | -9 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 388 | 9 | 1 | 3 | 5.0 | O=C(NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12)C1CC1 | 10.1016/j.bmcl.2003.12.052 | |||
137631636 | 163387 | 0 | None | 7 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 308 | 4 | 1 | 2 | 3.4 | CCC(=O)NC[C@@H]1CN(C)c2ccccc2[C@@H]1c1ccccc1 | 10.1021/acs.jmedchem.8b00359 | |||
CHEMBL4068887 | 163387 | 0 | None | 7 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 308 | 4 | 1 | 2 | 3.4 | CCC(=O)NC[C@@H]1CN(C)c2ccccc2[C@@H]1c1ccccc1 | 10.1021/acs.jmedchem.8b00359 | |||
44264861 | 211923 | 0 | None | 74 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 310 | 5 | 1 | 3 | 4.1 | CCCC(=O)Nc1ccc(N(C)c2cccc3c2CCO3)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7807 | 211923 | 0 | None | 74 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 310 | 5 | 1 | 3 | 4.1 | CCCC(=O)Nc1ccc(N(C)c2cccc3c2CCO3)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
11824365 | 114144 | 0 | None | 47 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1ccc(Cc2oc3ccc(OC)cc3c2CCNC(C)=O)cc1 | 10.1021/jm0005252 | |||
CHEMBL317742 | 114144 | 0 | None | 47 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 353 | 7 | 1 | 4 | 3.7 | COc1ccc(Cc2oc3ccc(OC)cc3c2CCNC(C)=O)cc1 | 10.1021/jm0005252 | |||
1359 | 8951 | 21 | None | 125 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 4.7 | CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 | 10.1021/jm980684+ | |||
5311198 | 8951 | 21 | None | 125 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 4.7 | CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 | 10.1021/jm980684+ | |||
CHEMBL274438 | 8951 | 21 | None | 125 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 4.7 | CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 | 10.1021/jm980684+ | |||
1359 | 8951 | 21 | None | 125 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 4.7 | CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 | 10.1021/jm800974d | |||
5311198 | 8951 | 21 | None | 125 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 4.7 | CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 | 10.1021/jm800974d | |||
CHEMBL274438 | 8951 | 21 | None | 125 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 4.7 | CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 | 10.1021/jm800974d | |||
137640407 | 163522 | 0 | None | 67 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 270 | 5 | 1 | 3 | 2.5 | COc1ccc2cccc(CCC(=O)NC3CC3)c2n1 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4070527 | 163522 | 0 | None | 67 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 270 | 5 | 1 | 3 | 2.5 | COc1ccc2cccc(CCC(=O)NC3CC3)c2n1 | 10.1016/j.ejmech.2016.12.013 | |||
11644612 | 85073 | 0 | None | 9 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 260 | 4 | 1 | 3 | 2.4 | COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C | 10.1021/jm0512544 | |||
CHEMBL210791 | 85073 | 0 | None | 9 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 260 | 4 | 1 | 3 | 2.4 | COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C | 10.1021/jm0512544 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2012.11.069 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2012.11.069 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2012.11.069 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2012.11.069 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2012.11.069 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2012.11.069 | |||
1359 | 8951 | 21 | None | 125 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 4.7 | CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 | 10.1021/jm401343c | |||
5311198 | 8951 | 21 | None | 125 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 4.7 | CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 | 10.1021/jm401343c | |||
CHEMBL274438 | 8951 | 21 | None | 125 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 4.7 | CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 | 10.1021/jm401343c | |||
1359 | 8951 | 21 | None | 125 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 4.7 | CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 | 10.1021/jm048956y | |||
5311198 | 8951 | 21 | None | 125 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 4.7 | CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 | 10.1021/jm048956y | |||
CHEMBL274438 | 8951 | 21 | None | 125 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 4.7 | CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 | 10.1021/jm048956y | |||
10704399 | 28279 | 0 | None | 8 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 225 | 2 | 1 | 1 | 2.6 | CC(=O)NCC1Cc2cccc3cccc1c23 | 10.1021/jm000922c | |||
CHEMBL131602 | 28279 | 0 | None | 8 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 225 | 2 | 1 | 1 | 2.6 | CC(=O)NCC1Cc2cccc3cccc1c23 | 10.1021/jm000922c | |||
10616723 | 105081 | 0 | None | 14 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 334 | 4 | 1 | 3 | 3.6 | COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCc2ccccc2-1 | 10.1021/jm980684+ | |||
CHEMBL274842 | 105081 | 0 | None | 14 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 334 | 4 | 1 | 3 | 3.6 | COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCc2ccccc2-1 | 10.1021/jm980684+ | |||
44579115 | 188614 | 0 | None | 162 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 4.2 | CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL477835 | 188614 | 0 | None | 162 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 4.2 | CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 | 10.1016/j.bmc.2008.08.052 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2015.12.047 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2015.12.047 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2015.12.047 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2015.12.047 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2015.12.047 | |||
12985494 | 197408 | 0 | None | 239 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 363 | 7 | 2 | 3 | 4.1 | CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL518113 | 197408 | 0 | None | 239 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 363 | 7 | 2 | 3 | 4.1 | CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 | 10.1016/j.bmc.2008.08.052 | |||
16094585 | 89665 | 0 | None | 204 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 321 | 6 | 1 | 2 | 4.0 | COc1cccc(/C(=C/CNC(=O)C2CCC2)c2ccccc2)c1 | 10.1021/jm060850a | |||
CHEMBL218065 | 89665 | 0 | None | 204 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 321 | 6 | 1 | 2 | 4.0 | COc1cccc(/C(=C/CNC(=O)C2CCC2)c2ccccc2)c1 | 10.1021/jm060850a | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm000922c | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm000922c | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm000922c | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm000922c | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm000922c | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm000922c | |||
24954991 | 70567 | 0 | None | -3 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 259 | 3 | 1 | 4 | 1.3 | CC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3 | 10.1021/jm200385u | |||
CHEMBL1802023 | 70567 | 0 | None | -3 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 259 | 3 | 1 | 4 | 1.3 | CC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3 | 10.1021/jm200385u | |||
23642307 | 165674 | 1 | None | 8 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 291 | 6 | 2 | 3 | 2.0 | COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1 | 10.1039/C4MD00149D | |||
CHEMBL4095334 | 165674 | 1 | None | 8 | 3 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 291 | 6 | 2 | 3 | 2.0 | COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1 | 10.1039/C4MD00149D | |||
44429448 | 94522 | 0 | None | 7 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 324 | 5 | 2 | 2 | 3.0 | CCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL233729 | 94522 | 0 | None | 7 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 324 | 5 | 2 | 2 | 3.0 | CCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
9948714 | 27476 | 0 | None | -2 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 313 | 5 | 1 | 3 | 3.4 | COc1ccc2ccc(OC)c3c2c1CCC3CCNC(C)=O | 10.1021/jm000922c | |||
CHEMBL130898 | 27476 | 0 | None | -2 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 313 | 5 | 1 | 3 | 3.4 | COc1ccc2ccc(OC)c3c2c1CCC3CCNC(C)=O | 10.1021/jm000922c | |||
9883864 | 123432 | 0 | None | -7 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 327 | 6 | 1 | 3 | 3.8 | CCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
CHEMBL337024 | 123432 | 0 | None | -7 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 327 | 6 | 1 | 3 | 3.8 | CCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
71508233 | 93849 | 0 | None | 40 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 355 | 10 | 1 | 3 | 3.9 | CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1 | 10.1016/j.bmc.2012.10.060 | |||
CHEMBL2326201 | 93849 | 0 | None | 40 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 355 | 10 | 1 | 3 | 3.9 | CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1 | 10.1016/j.bmc.2012.10.060 | |||
12985491 | 193759 | 0 | None | 91 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 411 | 6 | 1 | 2 | 5.1 | COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL490595 | 193759 | 0 | None | 91 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 411 | 6 | 1 | 2 | 5.1 | COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
10753255 | 125269 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 251 | 3 | 1 | 1 | 3.0 | O=C(NCC1Cc2cccc3cccc1c23)C1CC1 | 10.1021/jm000922c | |||
CHEMBL341439 | 125269 | 0 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 251 | 3 | 1 | 1 | 3.0 | O=C(NCC1Cc2cccc3cccc1c23)C1CC1 | 10.1021/jm000922c | |||
10778397 | 26607 | 0 | None | -1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 269 | 4 | 1 | 2 | 3.0 | COc1ccc2cccc3c2c1C(CCNC(C)=O)C3 | 10.1021/jm000922c | |||
CHEMBL130203 | 26607 | 0 | None | -1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 269 | 4 | 1 | 2 | 3.0 | COc1ccc2cccc3c2c1C(CCNC(C)=O)C3 | 10.1021/jm000922c | |||
52918077 | 67527 | 2 | None | 2 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 233 | 4 | 1 | 4 | 1.2 | COc1ccc2ccn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | |||
CHEMBL1760945 | 67527 | 2 | None | 2 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 233 | 4 | 1 | 4 | 1.2 | COc1ccc2ccn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | |||
127026427 | 144462 | 0 | None | 3 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 295 | 4 | 1 | 3 | 3.6 | COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL3758679 | 144462 | 0 | None | 3 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 295 | 4 | 1 | 3 | 3.6 | COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2010.06.100 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2010.06.100 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2010.06.100 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2010.06.100 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2010.06.100 | |||
44579260 | 193894 | 0 | None | 38 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 377 | 6 | 1 | 4 | 4.0 | COC(=O)c1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL491605 | 193894 | 0 | None | 38 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 377 | 6 | 1 | 4 | 4.0 | COC(=O)c1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 | 10.1016/j.bmc.2008.08.052 | |||
24750192 | 10689 | 13 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 222 | 5 | 1 | 3 | 1.3 | COc1cccc(c1)N(CCNC(=O)C)C | 10.1021/jm700957j | |||
7777 | 10689 | 13 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 222 | 5 | 1 | 3 | 1.3 | COc1cccc(c1)N(CCNC(=O)C)C | 10.1021/jm700957j | |||
CHEMBL237236 | 10689 | 13 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 222 | 5 | 1 | 3 | 1.3 | COc1cccc(c1)N(CCNC(=O)C)C | 10.1021/jm700957j | |||
11185529 | 10686 | 5 | None | 14 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 295 | 3 | 1 | 2 | 3.1 | COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 | 10.1021/jm040768k | |||
7772 | 10686 | 5 | None | 14 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 295 | 3 | 1 | 2 | 3.1 | COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 | 10.1021/jm040768k | |||
CHEMBL189449 | 10686 | 5 | None | 14 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 295 | 3 | 1 | 2 | 3.1 | COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 | 10.1021/jm040768k | |||
11185529 | 10686 | 5 | None | 14 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 295 | 3 | 1 | 2 | 3.1 | COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 | 10.1021/jm048956y | |||
7772 | 10686 | 5 | None | 14 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 295 | 3 | 1 | 2 | 3.1 | COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 | 10.1021/jm048956y | |||
CHEMBL189449 | 10686 | 5 | None | 14 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 295 | 3 | 1 | 2 | 3.1 | COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 | 10.1021/jm048956y | |||
44429447 | 94521 | 0 | None | 5 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 310 | 4 | 2 | 2 | 2.6 | COc1cc(Br)c2[nH]cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL233728 | 94521 | 0 | None | 5 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 310 | 4 | 2 | 2 | 2.6 | COc1cc(Br)c2[nH]cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.04.013 | |||
44429443 | 152123 | 0 | None | 4 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 274 | 6 | 2 | 2 | 2.9 | CCCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL391350 | 152123 | 0 | None | 4 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 274 | 6 | 2 | 2 | 2.9 | CCCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
44264871 | 211809 | 0 | None | 26 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 297 | 5 | 1 | 3 | 4.2 | CCCC(=O)Nc1ccc(Oc2cccc3c2CCO3)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7700 | 211809 | 0 | None | 26 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 297 | 5 | 1 | 3 | 4.2 | CCCC(=O)Nc1ccc(Oc2cccc3c2CCO3)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
52918080 | 67538 | 0 | None | 13 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 287 | 4 | 1 | 4 | 2.1 | COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3 | 10.1016/j.bmcl.2011.02.097 | |||
CHEMBL1760957 | 67538 | 0 | None | 13 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 287 | 4 | 1 | 4 | 2.1 | COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3 | 10.1016/j.bmcl.2011.02.097 | |||
9884156 | 214655 | 0 | None | 77 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 335 | 7 | 1 | 3 | 3.9 | C=CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
CHEMBL96548 | 214655 | 0 | None | 77 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 335 | 7 | 1 | 3 | 3.9 | C=CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
164946945 | 197008 | 1 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 427 | 9 | 1 | 7 | 3.3 | COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | |||
CHEMBL5174929 | 197008 | 1 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 427 | 9 | 1 | 7 | 3.3 | COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2005.01.015 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2005.01.015 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2005.01.015 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2005.01.015 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2005.01.015 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2005.01.015 | |||
127029516 | 144412 | 0 | None | 6 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 269 | 3 | 1 | 3 | 3.2 | COc1ccc2ccc3occ(CNC(C)=O)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL3758225 | 144412 | 0 | None | 6 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 269 | 3 | 1 | 3 | 3.2 | COc1ccc2ccc3occ(CNC(C)=O)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
127025784 | 144511 | 0 | None | 8 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 287 | 4 | 1 | 3 | 3.2 | COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL3759084 | 144511 | 0 | None | 8 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 287 | 4 | 1 | 3 | 3.2 | COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
15453084 | 93185 | 0 | None | -2 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 255 | 3 | 1 | 2 | 2.8 | COc1ccc2cccc([C@@H]3C[C@H]3NC(C)=O)c2c1 | 10.1016/j.bmcl.2012.11.069 | |||
CHEMBL2314251 | 93185 | 0 | None | -2 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 255 | 3 | 1 | 2 | 2.8 | COc1ccc2cccc([C@@H]3C[C@H]3NC(C)=O)c2c1 | 10.1016/j.bmcl.2012.11.069 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2004.07.055 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2004.07.055 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2004.07.055 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2004.07.055 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmcl.2004.07.055 | |||
44264904 | 212400 | 0 | None | 57 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 295 | 5 | 1 | 2 | 4.0 | CCCC(=O)Nc1ccc(Cc2cccc3c2CCO3)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL8169 | 212400 | 0 | None | 57 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 295 | 5 | 1 | 2 | 4.0 | CCCC(=O)Nc1ccc(Cc2cccc3c2CCO3)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
12985492 | 188610 | 0 | None | 177 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 459 | 6 | 1 | 2 | 5.1 | COc1ccc2cc(-c3cccc(CI)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL477833 | 188610 | 0 | None | 177 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 459 | 6 | 1 | 2 | 5.1 | COc1ccc2cc(-c3cccc(CI)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
11681026 | 83915 | 0 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 302 | 6 | 1 | 3 | 3.4 | CCCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12 | 10.1021/jm0512544 | |||
CHEMBL207745 | 83915 | 0 | None | 11 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 302 | 6 | 1 | 3 | 3.4 | CCCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12 | 10.1021/jm0512544 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.07.012 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.07.012 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.07.012 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.07.012 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.07.012 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2008.07.012 | |||
9947753 | 211679 | 0 | None | 83 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 285 | 6 | 1 | 3 | 4.2 | CCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7599 | 211679 | 0 | None | 83 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 285 | 6 | 1 | 3 | 4.2 | CCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
44264949 | 211747 | 0 | None | 83 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 299 | 7 | 1 | 3 | 4.6 | CCCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7650 | 211747 | 0 | None | 83 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 299 | 7 | 1 | 3 | 4.6 | CCCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
44272422 | 174658 | 0 | None | -3 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 288 | 5 | 2 | 3 | 3.1 | CCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL431103 | 174658 | 0 | None | -3 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 288 | 5 | 2 | 3 | 3.1 | CCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1 | 10.1016/j.bmcl.2003.12.052 | |||
59145872 | 192955 | 0 | None | -2 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 257 | 3 | 1 | 3 | 2.1 | CC(=O)NCCC1CCc2ccc3nn(C)cc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL4872592 | 192955 | 0 | None | -2 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 257 | 3 | 1 | 3 | 2.1 | CC(=O)NCCC1CCc2ccc3nn(C)cc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
10750842 | 195461 | 3 | None | 30 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 207 | 5 | 1 | 2 | 1.8 | COc1cccc(CCCNC(C)=O)c1 | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL50398 | 195461 | 3 | None | 30 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 207 | 5 | 1 | 2 | 1.8 | COc1cccc(CCCNC(C)=O)c1 | 10.1016/j.bmcl.2010.02.084 | |||
24750069 | 157262 | 0 | None | 66 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 298 | 7 | 1 | 3 | 2.8 | COc1cccc(N(CCNC(C)=O)Cc2ccccc2)c1 | 10.1021/jm700957j | |||
CHEMBL395437 | 157262 | 0 | None | 66 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 298 | 7 | 1 | 3 | 2.8 | COc1cccc(N(CCNC(C)=O)Cc2ccccc2)c1 | 10.1021/jm700957j | |||
53238411 | 68803 | 0 | None | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 375 | 4 | 1 | 2 | 4.9 | CC(=O)NCCC1=C(c2ccc(C(C)(C)C)cc2)Cc2ccc3c(c21)CCO3 | 10.1021/jm200221q | |||
CHEMBL1774530 | 68803 | 0 | None | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 375 | 4 | 1 | 2 | 4.9 | CC(=O)NCCC1=C(c2ccc(C(C)(C)C)cc2)Cc2ccc3c(c21)CCO3 | 10.1021/jm200221q | |||
10873443 | 202003 | 4 | None | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 417 | 5 | 1 | 5 | 2.4 | COc1cc2c(CCNC(C)=O)c(I)n(C)c2cc1[N+](=O)[O-] | 10.1021/jm011053+ | |||
CHEMBL55084 | 202003 | 4 | None | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 417 | 5 | 1 | 5 | 2.4 | COc1cc2c(CCNC(C)=O)c(I)n(C)c2cc1[N+](=O)[O-] | 10.1021/jm011053+ | |||
44264909 | 212013 | 0 | None | 117 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 293 | 5 | 1 | 2 | 4.8 | CCCC(=O)Nc1ccc(Cc2cccc3occc23)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7875 | 212013 | 0 | None | 117 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 293 | 5 | 1 | 2 | 4.8 | CCCC(=O)Nc1ccc(Cc2cccc3occc23)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
137641357 | 163858 | 0 | None | 3 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 280 | 3 | 1 | 2 | 3.1 | CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | |||
CHEMBL4074273 | 163858 | 0 | None | 3 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 280 | 3 | 1 | 2 | 3.1 | CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | |||
9817636 | 27447 | 0 | None | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 295 | 4 | 1 | 2 | 3.4 | COc1ccc2cccc3c2c1CCC3CNC(=O)C1CC1 | 10.1021/jm000922c | |||
CHEMBL130876 | 27447 | 0 | None | 1 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 295 | 4 | 1 | 2 | 3.4 | COc1ccc2cccc3c2c1CCC3CNC(=O)C1CC1 | 10.1021/jm000922c | |||
44272443 | 202266 | 0 | None | 2 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 302 | 6 | 2 | 3 | 3.5 | CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL553105 | 202266 | 0 | None | 2 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 302 | 6 | 2 | 3 | 3.5 | CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 | 10.1016/j.bmcl.2003.12.052 | |||
139451790 | 192075 | 18 | None | 2 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 297 | 5 | 1 | 5 | 1.8 | COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | |||
CHEMBL4859295 | 192075 | 18 | None | 2 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 297 | 5 | 1 | 5 | 1.8 | COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | |||
127025788 | 144545 | 0 | None | 53 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 300 | 3 | 2 | 3 | 3.2 | CNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL3759372 | 144545 | 0 | None | 53 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 300 | 3 | 2 | 3 | 3.2 | CNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1 | 10.1016/j.ejmech.2015.12.047 | |||
145983929 | 173200 | 0 | None | 6 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 284 | 4 | 1 | 3 | 2.8 | COc1ccc2ccc3c(c2n1)C(CCNC(C)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4277185 | 173200 | 0 | None | 6 | 3 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 284 | 4 | 1 | 3 | 2.8 | COc1ccc2ccc3c(c2n1)C(CCNC(C)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | |||
1348 | 8626 | 5 | None | 100 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 272 | 2 | 1 | 2 | 2.9 | COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C | 10.1021/jm401343c | |||
44208891 | 8626 | 5 | None | 100 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 272 | 2 | 1 | 2 | 2.9 | COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C | 10.1021/jm401343c | |||
CHEMBL3260983 | 8626 | 5 | None | 100 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 272 | 2 | 1 | 2 | 2.9 | COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C | 10.1021/jm401343c | |||
57381112 | 8198 | 0 | None | -20 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 279 | 5 | 1 | 2 | 2.8 | COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2 | 10.1039/C5MD00190K | |||
7776 | 8198 | 0 | None | -20 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 279 | 5 | 1 | 2 | 2.8 | COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2 | 10.1039/C5MD00190K | |||
CHEMBL1946221 | 8198 | 0 | None | -20 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 279 | 5 | 1 | 2 | 2.8 | COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2 | 10.1039/C5MD00190K | |||
57381112 | 8198 | 0 | None | -20 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 279 | 5 | 1 | 2 | 2.8 | COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2 | 10.1039/C5MD00190K | |||
7776 | 8198 | 0 | None | -20 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 279 | 5 | 1 | 2 | 2.8 | COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2 | 10.1039/C5MD00190K | |||
CHEMBL1946221 | 8198 | 0 | None | -20 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 279 | 5 | 1 | 2 | 2.8 | COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2 | 10.1039/C5MD00190K | |||
11536939 | 83889 | 0 | None | 12 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 314 | 6 | 1 | 3 | 3.5 | CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1 | 10.1021/jm0512544 | |||
CHEMBL207625 | 83889 | 0 | None | 12 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 314 | 6 | 1 | 3 | 3.5 | CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1 | 10.1021/jm0512544 | |||
53231366 | 69175 | 0 | None | 66 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 363 | 5 | 1 | 3 | 5.0 | CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | |||
CHEMBL1779804 | 69175 | 0 | None | 66 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 363 | 5 | 1 | 3 | 5.0 | CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | |||
24750188 | 156023 | 0 | None | 114 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 314 | 7 | 1 | 4 | 3.0 | COc1ccc(N(CCNC(C)=O)c2cccc(OC)c2)cc1 | 10.1021/jm700957j | |||
CHEMBL394430 | 156023 | 0 | None | 114 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 314 | 7 | 1 | 4 | 3.0 | COc1ccc(N(CCNC(C)=O)c2cccc(OC)c2)cc1 | 10.1021/jm700957j | |||
44272440 | 74300 | 0 | None | -2 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 260 | 4 | 2 | 3 | 2.5 | CCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL18960 | 74300 | 0 | None | -2 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 260 | 4 | 2 | 3 | 2.5 | CCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1 | 10.1016/j.bmcl.2003.12.052 | |||
11426853 | 173147 | 0 | None | 3 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 309 | 3 | 1 | 3 | 2.7 | COc1ccc2c(c1)C(CNC(C)=O)Cc1ccccc1C2=O | 10.1021/jm040768k | |||
CHEMBL427516 | 173147 | 0 | None | 3 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 309 | 3 | 1 | 3 | 2.7 | COc1ccc2c(c1)C(CNC(C)=O)Cc1ccccc1C2=O | 10.1021/jm040768k | |||
10044270 | 196323 | 0 | None | 891 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 363 | 6 | 1 | 2 | 4.8 | COc1ccc2c(c1)[C@@H](CCNC(=O)C1CCC1)C[C@@H](c1ccccc1)C2 | 10.1021/jm800974d | |||
CHEMBL514280 | 196323 | 0 | None | 891 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 363 | 6 | 1 | 2 | 4.8 | COc1ccc2c(c1)[C@@H](CCNC(=O)C1CCC1)C[C@@H](c1ccccc1)C2 | 10.1021/jm800974d | |||
139451757 | 191610 | 0 | None | -1 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 311 | 6 | 1 | 5 | 2.2 | CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | |||
CHEMBL4852096 | 191610 | 0 | None | -1 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 311 | 6 | 1 | 5 | 2.2 | CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | |||
139451795 | 192108 | 0 | None | -2 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 277 | 6 | 1 | 5 | 1.6 | CCOc1nc2ccc(OC)cc2n1CCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | |||
CHEMBL4859677 | 192108 | 0 | None | -2 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 277 | 6 | 1 | 5 | 1.6 | CCOc1nc2ccc(OC)cc2n1CCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | |||
24954992 | 70572 | 0 | None | -1 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 313 | 3 | 1 | 4 | 2.0 | CC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3 | 10.1021/jm200385u | |||
CHEMBL1802029 | 70572 | 0 | None | -1 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 313 | 3 | 1 | 4 | 2.0 | CC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3 | 10.1021/jm200385u | |||
44358274 | 35726 | 0 | None | -1 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 261 | 2 | 2 | 3 | 1.1 | CNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL138012 | 35726 | 0 | None | -1 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 261 | 2 | 2 | 3 | 1.1 | CNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
44579163 | 188908 | 0 | None | 53 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 362 | 6 | 1 | 3 | 4.3 | COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL478217 | 188908 | 0 | None | 53 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 362 | 6 | 1 | 3 | 4.3 | COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
10712600 | 11130 | 0 | None | 48 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 346 | 5 | 1 | 3 | 3.7 | COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1 | 10.1021/jm980684+ | |||
CHEMBL10110 | 11130 | 0 | None | 48 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 346 | 5 | 1 | 3 | 3.7 | COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1 | 10.1021/jm980684+ | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
12985493 | 193871 | 0 | None | 213 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 363 | 7 | 1 | 3 | 4.3 | COCc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL491403 | 193871 | 0 | None | 213 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 363 | 7 | 1 | 3 | 4.3 | COCc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 | 10.1016/j.bmc.2008.08.052 | |||
25025104 | 193094 | 0 | None | -5 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 271 | 4 | 1 | 3 | 2.6 | CCC(=O)NCCC1CCc2ccn3nc(C)cc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL4874630 | 193094 | 0 | None | -5 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 271 | 4 | 1 | 3 | 2.6 | CCC(=O)NCCC1CCc2ccn3nc(C)cc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1039/C1MD00149C | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1039/C1MD00149C | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1039/C1MD00149C | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1039/C1MD00149C | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1039/C1MD00149C | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1039/C1MD00149C | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1039/C5MD00190K | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1039/C5MD00190K | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1039/C5MD00190K | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1039/C5MD00190K | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1039/C5MD00190K | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1039/C5MD00190K | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm800974d | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm800974d | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm800974d | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm800974d | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm800974d | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1021/jm800974d | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2009.04.068 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2009.04.068 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2009.04.068 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2009.04.068 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2009.04.068 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.bmc.2009.04.068 | |||
10061064 | 109745 | 0 | None | 7 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 258 | 5 | 1 | 3 | 2.3 | CCC(=O)NCCc1ccnc2ccc(OC)cc12 | 10.1016/S0960-894X(97)00392-2 | |||
CHEMBL306468 | 109745 | 0 | None | 7 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 258 | 5 | 1 | 3 | 2.3 | CCC(=O)NCCc1ccnc2ccc(OC)cc12 | 10.1016/S0960-894X(97)00392-2 | |||
23658144 | 164958 | 1 | None | 6 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 291 | 6 | 2 | 3 | 2.0 | COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1 | 10.1039/C4MD00149D | |||
CHEMBL4087633 | 164958 | 1 | None | 6 | 3 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 291 | 6 | 2 | 3 | 2.0 | COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1 | 10.1039/C4MD00149D | |||
44358184 | 123318 | 0 | None | 1 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 246 | 2 | 1 | 3 | 1.3 | CC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL336268 | 123318 | 0 | None | 1 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 246 | 2 | 1 | 3 | 1.3 | CC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
10015475 | 23535 | 0 | None | 3 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 260 | 6 | 1 | 3 | 2.8 | CCC(=O)NCCCc1cccc2nc(CC)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL124362 | 23535 | 0 | None | 3 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 260 | 6 | 1 | 3 | 2.8 | CCC(=O)NCCCc1cccc2nc(CC)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
9970584 | 23543 | 0 | None | 8 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 274 | 7 | 1 | 3 | 3.2 | CCCC(=O)NCCCc1cccc2nc(CC)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL124422 | 23543 | 0 | None | 8 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 274 | 7 | 1 | 3 | 3.2 | CCCC(=O)NCCCc1cccc2nc(CC)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
44272444 | 74721 | 0 | None | 3 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 303 | 6 | 3 | 3 | 3.0 | CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)NCC)c2O1 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL19109 | 74721 | 0 | None | 3 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 303 | 6 | 3 | 3 | 3.0 | CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)NCC)c2O1 | 10.1016/j.bmcl.2003.12.052 | |||
137636079 | 163006 | 0 | None | 19 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 232 | 3 | 1 | 2 | 1.8 | CCN1CC(CNC(C)=O)Cc2ccccc21 | 10.1021/acs.jmedchem.8b00359 | |||
CHEMBL4064626 | 163006 | 0 | None | 19 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 232 | 3 | 1 | 2 | 1.8 | CCN1CC(CNC(C)=O)Cc2ccccc21 | 10.1021/acs.jmedchem.8b00359 | |||
137645887 | 164719 | 0 | None | 58 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 294 | 4 | 1 | 2 | 3.0 | CC(=O)NCC1Cc2ccccc2N(Cc2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | |||
CHEMBL4084568 | 164719 | 0 | None | 58 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 294 | 4 | 1 | 2 | 3.0 | CC(=O)NCC1Cc2ccccc2N(Cc2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | |||
86273226 | 128096 | 0 | None | 5 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 256 | 5 | 2 | 2 | 1.9 | C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12 | 10.1021/acs.jmedchem.5b00245 | |||
CHEMBL3580908 | 128096 | 0 | None | 5 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 256 | 5 | 2 | 2 | 1.9 | C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12 | 10.1021/acs.jmedchem.5b00245 | |||
137660726 | 166111 | 0 | None | 15 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 322 | 6 | 1 | 5 | 1.6 | CCS(=O)(=O)NC(=O)CCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4100108 | 166111 | 0 | None | 15 | 2 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 322 | 6 | 1 | 5 | 1.6 | CCS(=O)(=O)NC(=O)CCc1cccc2ccc(OC)nc12 | 10.1016/j.ejmech.2016.12.013 | |||
11550834 | 146322 | 0 | None | 4 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 274 | 5 | 1 | 3 | 2.8 | CCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12 | 10.1021/jm0512544 | |||
CHEMBL379616 | 146322 | 0 | None | 4 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 274 | 5 | 1 | 3 | 2.8 | CCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12 | 10.1021/jm0512544 | |||
44429442 | 157002 | 0 | None | 1 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 260 | 5 | 2 | 2 | 2.6 | CCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL395221 | 157002 | 0 | None | 1 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 260 | 5 | 2 | 2 | 2.6 | CCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
25210130 | 6857 | 0 | None | 91 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 363 | 6 | 2 | 3 | 3.4 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2 | 10.1021/jm800974d | |||
7782 | 6857 | 0 | None | 91 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 363 | 6 | 2 | 3 | 3.4 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2 | 10.1021/jm800974d | |||
CHEMBL514415 | 6857 | 0 | None | 91 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 363 | 6 | 2 | 3 | 3.4 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2 | 10.1021/jm800974d | |||
57781248 | 191342 | 0 | None | 1 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 274 | 4 | 2 | 4 | 1.9 | CC(=O)NCCC1CCc2ccc3nc(CO)oc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL4848381 | 191342 | 0 | None | 1 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 274 | 4 | 2 | 4 | 1.9 | CC(=O)NCCC1CCc2ccc3nc(CO)oc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
11507534 | 172912 | 0 | None | 5 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 288 | 5 | 1 | 3 | 3.0 | CCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12 | 10.1021/jm0512544 | |||
CHEMBL426127 | 172912 | 0 | None | 5 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 288 | 5 | 1 | 3 | 3.0 | CCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12 | 10.1021/jm0512544 | |||
11784134 | 113726 | 0 | None | 67 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 391 | 6 | 1 | 3 | 4.7 | COc1ccc2oc(Cc3cccc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
CHEMBL314947 | 113726 | 0 | None | 67 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 391 | 6 | 1 | 3 | 4.7 | COc1ccc2oc(Cc3cccc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
25210130 | 6857 | 0 | None | 91 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 363 | 6 | 2 | 3 | 3.4 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2 | 10.1021/jm800974d | |||
7782 | 6857 | 0 | None | 91 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 363 | 6 | 2 | 3 | 3.4 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2 | 10.1021/jm800974d | |||
CHEMBL514415 | 6857 | 0 | None | 91 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 363 | 6 | 2 | 3 | 3.4 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2 | 10.1021/jm800974d | |||
44272431 | 105633 | 0 | None | 4 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 274 | 4 | 2 | 3 | 2.7 | CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL278922 | 105633 | 0 | None | 4 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 274 | 4 | 2 | 3 | 2.7 | CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 | 10.1016/j.bmcl.2003.12.052 | |||
19703015 | 144676 | 0 | None | 1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 234 | 4 | 1 | 4 | 1.5 | COc1ccc2occ(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
CHEMBL3763281 | 144676 | 0 | None | 1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 234 | 4 | 1 | 4 | 1.5 | COc1ccc2occ(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
10754723 | 175977 | 0 | None | 1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 273 | 5 | 2 | 3 | 2.6 | CCC(=O)NCCc1c(O)ccc2ccc(OC)cc12 | 10.1016/S0960-894X(97)00444-7 | |||
CHEMBL440692 | 175977 | 0 | None | 1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 273 | 5 | 2 | 3 | 2.6 | CCC(=O)NCCc1c(O)ccc2ccc(OC)cc12 | 10.1016/S0960-894X(97)00444-7 | |||
44317845 | 212285 | 0 | None | -3 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 301 | 7 | 1 | 3 | 3.3 | CCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC | 10.1016/S0960-894X(97)00444-7 | |||
CHEMBL80736 | 212285 | 0 | None | -3 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 301 | 7 | 1 | 3 | 3.3 | CCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC | 10.1016/S0960-894X(97)00444-7 | |||
11587169 | 84092 | 0 | None | 8 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 274 | 4 | 1 | 3 | 2.6 | COc1ccc2c(c1)c(C(C)(C)CNC(C)=O)cn2C | 10.1021/jm0512544 | |||
CHEMBL208307 | 84092 | 0 | None | 8 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 274 | 4 | 1 | 3 | 2.6 | COc1ccc2c(c1)c(C(C)(C)CNC(C)=O)cn2C | 10.1021/jm0512544 | |||
127039212 | 144805 | 0 | None | 154 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 360 | 5 | 1 | 4 | 4.3 | COc1ccc2oc(-c3cccc4ccccc34)c(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
CHEMBL3764879 | 144805 | 0 | None | 154 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 360 | 5 | 1 | 4 | 4.3 | COc1ccc2oc(-c3cccc4ccccc34)c(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
10495702 | 212014 | 0 | None | 3 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 317 | 8 | 2 | 4 | 2.3 | CCC(=O)NCCc1c(OCCO)ccc2ccc(OC)cc12 | 10.1016/S0960-894X(97)00444-7 | |||
CHEMBL78751 | 212014 | 0 | None | 3 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 317 | 8 | 2 | 4 | 2.3 | CCC(=O)NCCc1c(OCCO)ccc2ccc(OC)cc12 | 10.1016/S0960-894X(97)00444-7 | |||
44429449 | 94138 | 0 | None | 7 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 324 | 4 | 1 | 3 | 2.6 | COc1cc(Br)c2c(c1)c(CCNC(C)=O)cn2C | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL233309 | 94138 | 0 | None | 7 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 324 | 4 | 1 | 3 | 2.6 | COc1cc(Br)c2c(c1)c(CCNC(C)=O)cn2C | 10.1016/j.bmc.2007.04.013 | |||
44429446 | 153510 | 0 | None | 14 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 288 | 6 | 1 | 3 | 3.0 | CCCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL392422 | 153510 | 0 | None | 14 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 288 | 6 | 1 | 3 | 3.0 | CCCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
137641357 | 163858 | 0 | None | 3 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 280 | 3 | 1 | 2 | 3.1 | CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | |||
CHEMBL4074273 | 163858 | 0 | None | 3 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 280 | 3 | 1 | 2 | 3.1 | CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | |||
10399579 | 210762 | 0 | None | 4 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 244 | 4 | 1 | 3 | 1.9 | COc1ccc2nccc(CCNC(C)=O)c2c1 | 10.1016/S0960-894X(97)00392-2 | |||
CHEMBL69521 | 210762 | 0 | None | 4 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 244 | 4 | 1 | 3 | 1.9 | COc1ccc2nccc(CCNC(C)=O)c2c1 | 10.1016/S0960-894X(97)00392-2 | |||
139451769 | 192921 | 0 | None | -1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 291 | 7 | 1 | 5 | 2.0 | CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC | 10.1021/acs.jmedchem.0c00627 | |||
CHEMBL4872217 | 192921 | 0 | None | -1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 291 | 7 | 1 | 5 | 2.0 | CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC | 10.1021/acs.jmedchem.0c00627 | |||
59145922 | 193051 | 0 | None | -7 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 257 | 3 | 1 | 3 | 2.2 | CC(=O)NCCC1CCc2ccn3nc(C)cc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL4874010 | 193051 | 0 | None | -7 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 257 | 3 | 1 | 3 | 2.2 | CC(=O)NCCC1CCc2ccn3nc(C)cc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
44426096 | 92511 | 0 | None | 4 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 211 | 2 | 1 | 1 | 2.9 | CC(=O)N/C=C/c1cccc2ccccc12 | 10.1016/j.bmcl.2012.11.069 | |||
CHEMBL229015 | 92511 | 0 | None | 4 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 211 | 2 | 1 | 1 | 2.9 | CC(=O)N/C=C/c1cccc2ccccc12 | 10.1016/j.bmcl.2012.11.069 | |||
10737372 | 11404 | 0 | None | 37 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.3 | CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCCc1ccccc1-2 | 10.1021/jm980684+ | |||
CHEMBL10293 | 11404 | 0 | None | 37 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.3 | CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCCc1ccccc1-2 | 10.1021/jm980684+ | |||
1358 | 6912 | 41 | None | 870 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | 10.1021/jm401343c | |||
3976006 | 6912 | 41 | None | 870 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | 10.1021/jm401343c | |||
CHEMBL285718 | 6912 | 41 | None | 870 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | 10.1021/jm401343c | |||
9819843 | 214917 | 0 | None | 20 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 351 | 8 | 1 | 3 | 4.3 | COc1ccc2oc(CCCc3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
CHEMBL98074 | 214917 | 0 | None | 20 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 351 | 8 | 1 | 3 | 4.3 | COc1ccc2oc(CCCc3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
16094594 | 90021 | 0 | None | 165 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 321 | 6 | 1 | 2 | 4.0 | COc1cccc(/C(=C\CNC(=O)C2CCC2)c2ccccc2)c1 | 10.1021/jm060850a | |||
CHEMBL218709 | 90021 | 0 | None | 165 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 321 | 6 | 1 | 2 | 4.0 | COc1cccc(/C(=C\CNC(=O)C2CCC2)c2ccccc2)c1 | 10.1021/jm060850a | |||
44429444 | 153509 | 0 | None | 5 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 260 | 4 | 1 | 3 | 2.2 | COc1cc(C)c2c(c1)c(CCNC(C)=O)cn2C | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL392421 | 153509 | 0 | None | 5 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 260 | 4 | 1 | 3 | 2.2 | COc1cc(C)c2c(c1)c(CCNC(C)=O)cn2C | 10.1016/j.bmc.2007.04.013 | |||
10640828 | 28254 | 0 | None | -2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 339 | 6 | 1 | 3 | 3.8 | COc1ccc2ccc(OC)c3c2c1CCC3CCNC(=O)C1CC1 | 10.1021/jm000922c | |||
CHEMBL131575 | 28254 | 0 | None | -2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 339 | 6 | 1 | 3 | 3.8 | COc1ccc2ccc(OC)c3c2c1CCC3CCNC(=O)C1CC1 | 10.1021/jm000922c | |||
46885284 | 14877 | 0 | None | 114 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 251 | 7 | 1 | 3 | 2.2 | CCOc1ccc(OC)cc1CCCNC(C)=O | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL1091561 | 14877 | 0 | None | 114 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 251 | 7 | 1 | 3 | 2.2 | CCOc1ccc(OC)cc1CCCNC(C)=O | 10.1016/j.bmcl.2010.02.084 | |||
139451766 | 191226 | 0 | None | 8 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 325 | 7 | 1 | 5 | 2.6 | CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | |||
CHEMBL4846505 | 191226 | 0 | None | 8 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 325 | 7 | 1 | 5 | 2.6 | CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | |||
10831675 | 28552 | 0 | None | 6 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 349 | 7 | 1 | 4 | 3.1 | CCC(=O)NCCc1c(OC(=O)CCl)ccc2ccc(OC)cc12 | 10.1021/jm970437q | |||
CHEMBL131919 | 28552 | 0 | None | 6 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 349 | 7 | 1 | 4 | 3.1 | CCC(=O)NCCc1c(OC(=O)CCl)ccc2ccc(OC)cc12 | 10.1021/jm970437q | |||
46884552 | 14899 | 0 | None | 1122 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 314 | 8 | 1 | 4 | 2.7 | COc1ccc(OCc2ccccn2)c(CCCNC(C)=O)c1 | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL1091716 | 14899 | 0 | None | 1122 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 314 | 8 | 1 | 4 | 2.7 | COc1ccc(OCc2ccccn2)c(CCCNC(C)=O)c1 | 10.1016/j.bmcl.2010.02.084 | |||
10567865 | 10950 | 0 | None | 38 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 3.7 | CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1 | 10.1021/jm001125h | |||
CHEMBL100104 | 10950 | 0 | None | 38 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 3.7 | CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1 | 10.1021/jm001125h | |||
46865422 | 93846 | 0 | None | 575 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 357 | 10 | 1 | 4 | 3.7 | CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1 | 10.1039/C1MD00149C | |||
CHEMBL2326199 | 93846 | 0 | None | 575 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 357 | 10 | 1 | 4 | 3.7 | CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1 | 10.1039/C1MD00149C | |||
12324 | 10683 | 0 | None | -2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 591 | 13 | 3 | 4 | 7.0 | O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1 | 10.1021/acs.jmedchem.8b00893 | |||
145966622 | 10683 | 0 | None | -2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 591 | 13 | 3 | 4 | 7.0 | O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1 | 10.1021/acs.jmedchem.8b00893 | |||
CHEMBL4210086 | 10683 | 0 | None | -2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 591 | 13 | 3 | 4 | 7.0 | O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1 | 10.1021/acs.jmedchem.8b00893 | |||
11068422 | 214623 | 0 | None | 7 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 361 | 6 | 1 | 4 | 4.7 | COc1ccc2oc(-c3ccccc3)c(CCNC(=O)c3ccco3)c2c1 | 10.1021/jm0005252 | |||
CHEMBL96420 | 214623 | 0 | None | 7 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 361 | 6 | 1 | 4 | 4.7 | COc1ccc2oc(-c3ccccc3)c(CCNC(=O)c3ccco3)c2c1 | 10.1021/jm0005252 | |||
127026424 | 144470 | 0 | None | 5 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 283 | 4 | 1 | 3 | 3.3 | COc1ccc2ccc3oc(CCNC(C)=O)cc3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL3758720 | 144470 | 0 | None | 5 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 283 | 4 | 1 | 3 | 3.3 | COc1ccc2ccc3oc(CCNC(C)=O)cc3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
46865422 | 93846 | 0 | None | 575 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 357 | 10 | 1 | 4 | 3.7 | CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1 | 10.1016/j.ejmech.2016.01.008 | |||
CHEMBL2326199 | 93846 | 0 | None | 575 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 357 | 10 | 1 | 4 | 3.7 | CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1 | 10.1016/j.ejmech.2016.01.008 | |||
11776674 | 123427 | 1 | None | 1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 246 | 4 | 1 | 3 | 1.9 | COc1ccc2c(c1)c(CCNC(C)=O)cn2C | 10.1021/jm020982d | |||
CHEMBL33700 | 123427 | 1 | None | 1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 246 | 4 | 1 | 3 | 1.9 | COc1ccc2c(c1)c(CCNC(C)=O)cn2C | 10.1021/jm020982d | |||
44429441 | 93501 | 0 | None | 1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 246 | 4 | 2 | 2 | 2.2 | COc1cc(C)c2[nH]cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL231872 | 93501 | 0 | None | 1 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 246 | 4 | 2 | 2 | 2.2 | COc1cc(C)c2[nH]cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.04.013 | |||
9914839 | 104932 | 0 | None | -34 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 526 | 14 | 2 | 4 | 6.0 | CC(=O)NCCc1cccc2ccc(OCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 | 10.1021/jm0255872 | |||
CHEMBL273787 | 104932 | 0 | None | -34 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 526 | 14 | 2 | 4 | 6.0 | CC(=O)NCCc1cccc2ccc(OCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 | 10.1021/jm0255872 | |||
10424693 | 116420 | 1 | None | 2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 297 | 4 | 1 | 2 | 3.1 | COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1 | 10.1039/C5MD00190K | |||
CHEMBL322339 | 116420 | 1 | None | 2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 297 | 4 | 1 | 2 | 3.1 | COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1 | 10.1039/C5MD00190K | |||
127038129 | 143650 | 0 | None | 2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 311 | 5 | 1 | 2 | 3.3 | COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1 | 10.1039/C5MD00190K | |||
CHEMBL3742090 | 143650 | 0 | None | 2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 311 | 5 | 1 | 2 | 3.3 | COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1 | 10.1039/C5MD00190K | |||
22718564 | 23552 | 0 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 232 | 5 | 1 | 3 | 2.3 | CCC(=O)NCCCc1cccc2ncoc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL124476 | 23552 | 0 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 232 | 5 | 1 | 3 | 2.3 | CCC(=O)NCCCc1cccc2ncoc12 | 10.1016/j.bmcl.2004.04.082 | |||
44264706 | 211209 | 1 | None | 33 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 270 | 5 | 2 | 3 | 3.8 | CCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7215 | 211209 | 1 | None | 33 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 270 | 5 | 2 | 3 | 3.8 | CCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
46888521 | 15416 | 0 | None | -26 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 499 | 12 | 1 | 5 | 5.6 | COC(=O)Cc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
CHEMBL1095196 | 15416 | 0 | None | -26 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 499 | 12 | 1 | 5 | 5.6 | COC(=O)Cc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
10611901 | 30348 | 0 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 267 | 5 | 1 | 1 | 3.8 | CCCC(=O)NCCC1Cc2cccc3cccc1c23 | 10.1021/jm000922c | |||
CHEMBL133426 | 30348 | 0 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 267 | 5 | 1 | 1 | 3.8 | CCCC(=O)NCCC1Cc2cccc3cccc1c23 | 10.1021/jm000922c | |||
10729569 | 123334 | 0 | None | 2 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 253 | 4 | 1 | 1 | 3.4 | CCC(=O)NCCC1Cc2cccc3cccc1c23 | 10.1021/jm000922c | |||
CHEMBL336333 | 123334 | 0 | None | 2 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 253 | 4 | 1 | 1 | 3.4 | CCC(=O)NCCC1Cc2cccc3cccc1c23 | 10.1021/jm000922c | |||
12985489 | 197015 | 0 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2cc(-c3ccccc3CO)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL517502 | 197015 | 0 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2cc(-c3ccccc3CO)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
44272305 | 74097 | 0 | None | -14 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 392 | 9 | 2 | 3 | 5.1 | CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL18845 | 74097 | 0 | None | -14 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 392 | 9 | 2 | 3 | 5.1 | CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2 | 10.1016/j.bmcl.2003.12.052 | |||
24750193 | 95328 | 1 | None | -2 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 236 | 6 | 1 | 3 | 1.7 | COc1cccc(N(C)CCCNC(C)=O)c1 | 10.1021/jm700957j | |||
CHEMBL235329 | 95328 | 1 | None | -2 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 236 | 6 | 1 | 3 | 1.7 | COc1cccc(N(C)CCCNC(C)=O)c1 | 10.1021/jm700957j | |||
168274836 | 196926 | 0 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 411 | 7 | 1 | 7 | 3.4 | COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | |||
CHEMBL5173623 | 196926 | 0 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 411 | 7 | 1 | 7 | 3.4 | COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | |||
22718610 | 23660 | 0 | None | 1 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 308 | 6 | 1 | 3 | 4.0 | CCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL125033 | 23660 | 0 | None | 1 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 308 | 6 | 1 | 3 | 4.0 | CCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
9797715 | 211719 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 333 | 6 | 1 | 4 | 3.3 | CCCC(=O)Nc1ccc(S(=O)(=O)c2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7637 | 211719 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 333 | 6 | 1 | 4 | 3.3 | CCCC(=O)Nc1ccc(S(=O)(=O)c2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL3109563 | 217870 | 0 | None | 3 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | None | None | None | COc1ccc2c(c1)c(CCNC(C)=O)c1n2[B-](F)(F)[N+]2=C(C)C=C(C)C2=C1 | 10.1021/ml4004155 | |||||
10545399 | 212291 | 0 | None | 4 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 344 | 9 | 1 | 4 | 2.9 | CCC(=O)NCCc1c(OCCN(C)C)ccc2ccc(OC)cc12 | 10.1016/S0960-894X(97)00444-7 | |||
CHEMBL80792 | 212291 | 0 | None | 4 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 344 | 9 | 1 | 4 | 2.9 | CCC(=O)NCCc1c(OCCN(C)C)ccc2ccc(OC)cc12 | 10.1016/S0960-894X(97)00444-7 | |||
44394435 | 73701 | 0 | None | -3 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 361 | 8 | 1 | 2 | 5.2 | CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL186586 | 73701 | 0 | None | -3 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 361 | 8 | 1 | 2 | 5.2 | CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
44394415 | 131185 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 389 | 10 | 1 | 2 | 6.0 | CCCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL363947 | 131185 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 389 | 10 | 1 | 2 | 6.0 | CCCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
122162 | 9166 | 75 | None | 18 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 10.1021/jm401343c | |||
1363 | 9166 | 75 | None | 18 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 10.1021/jm401343c | |||
CHEMBL286615 | 9166 | 75 | None | 18 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 10.1021/jm401343c | |||
11066802 | 106863 | 0 | None | 21 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 308 | 5 | 1 | 3 | 3.7 | CCC(=O)NCc1cc2c(OC)cccc2n1-c1ccccc1 | 10.1021/jm001125h | |||
CHEMBL287343 | 106863 | 0 | None | 21 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 308 | 5 | 1 | 3 | 3.7 | CCC(=O)NCc1cc2c(OC)cccc2n1-c1ccccc1 | 10.1021/jm001125h | |||
11098363 | 175895 | 1 | None | 14 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 293 | 5 | 1 | 2 | 3.7 | CC(=O)NCCc1c(Cc2ccccc2)oc2ccccc12 | 10.1021/jm0005252 | |||
CHEMBL440144 | 175895 | 1 | None | 14 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 293 | 5 | 1 | 2 | 3.7 | CC(=O)NCCc1c(Cc2ccccc2)oc2ccccc12 | 10.1021/jm0005252 | |||
53231464 | 69180 | 0 | None | 21 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 5.2 | C=CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | |||
CHEMBL1779809 | 69180 | 0 | None | 21 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 375 | 6 | 1 | 3 | 5.2 | C=CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | |||
44358275 | 175232 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 287 | 3 | 2 | 3 | 1.7 | O=C(NC1CC1)N[C@@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL435023 | 175232 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 287 | 3 | 2 | 3 | 1.7 | O=C(NC1CC1)N[C@@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
9937825 | 15640 | 0 | None | -12 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 564 | 17 | 2 | 4 | 6.7 | C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
CHEMBL1097315 | 15640 | 0 | None | -12 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 564 | 17 | 2 | 4 | 6.7 | C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
56661512 | 71221 | 0 | None | -23 | 2 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 470 | 15 | 2 | 6 | 3.1 | CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 | 10.1016/j.bmc.2011.06.063 | |||
CHEMBL1813319 | 71221 | 0 | None | -23 | 2 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 470 | 15 | 2 | 6 | 3.1 | CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 | 10.1016/j.bmc.2011.06.063 | |||
11681201 | 147854 | 0 | None | 2 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 314 | 5 | 1 | 3 | 3.5 | CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1 | 10.1021/jm0512544 | |||
CHEMBL382555 | 147854 | 0 | None | 2 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 314 | 5 | 1 | 3 | 3.5 | CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1 | 10.1021/jm0512544 | |||
46884550 | 14956 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 409 | 8 | 1 | 3 | 4.2 | COc1ccc(OCc2ccc(Br)cc2F)c(CCCNC(C)=O)c1 | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL1091997 | 14956 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 409 | 8 | 1 | 3 | 4.2 | COc1ccc(OCc2ccc(Br)cc2F)c(CCCNC(C)=O)c1 | 10.1016/j.bmcl.2010.02.084 | |||
44412079 | 173036 | 0 | None | 1 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 286 | 4 | 2 | 3 | 2.8 | CCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1 | 10.1021/jm0512544 | |||
CHEMBL426861 | 173036 | 0 | None | 1 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 286 | 4 | 2 | 3 | 2.8 | CCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1 | 10.1021/jm0512544 | |||
46884599 | 15191 | 0 | None | 13 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 343 | 9 | 1 | 4 | 3.4 | COc1cccc(COc2ccc(CCCNC(C)=O)cc2OC)c1 | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL1093457 | 15191 | 0 | None | 13 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 343 | 9 | 1 | 4 | 3.4 | COc1cccc(COc2ccc(CCCNC(C)=O)cc2OC)c1 | 10.1016/j.bmcl.2010.02.084 | |||
9795837 | 168578 | 4 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 285 | 6 | 1 | 3 | 4.2 | CCCC(=O)Nc1ccc(Oc2ccccc2OC)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL414212 | 168578 | 4 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 285 | 6 | 1 | 3 | 4.2 | CCCC(=O)Nc1ccc(Oc2ccccc2OC)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
162661094 | 188222 | 3 | None | 10 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 273 | 6 | 1 | 4 | 2.1 | CCCC(=O)NCCc1nncc2ccc(OC)cc12 | 10.1016/j.ejmech.2020.112078 | |||
CHEMBL4764211 | 188222 | 3 | None | 10 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 273 | 6 | 1 | 4 | 2.1 | CCCC(=O)NCCc1nncc2ccc(OC)cc12 | 10.1016/j.ejmech.2020.112078 | |||
49865203 | 22621 | 0 | None | -2 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 223 | 5 | 1 | 3 | 1.6 | COc1cccc(O[C@H](C)CNC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223049 | 22621 | 0 | None | -2 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 223 | 5 | 1 | 3 | 1.6 | COc1cccc(O[C@H](C)CNC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
54583162 | 67535 | 0 | None | 7 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 276 | 6 | 2 | 5 | 0.9 | CNCc1cn(CCNC(C)=O)c2nc(OC)ccc12 | 10.1016/j.bmcl.2011.02.097 | |||
CHEMBL1760954 | 67535 | 0 | None | 7 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 276 | 6 | 2 | 5 | 0.9 | CNCc1cn(CCNC(C)=O)c2nc(OC)ccc12 | 10.1016/j.bmcl.2011.02.097 | |||
11208578 | 132667 | 0 | None | 1 | 2 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 292 | 2 | 1 | 2 | 3.0 | CC(=O)NCC(=O)N1c2ccccc2C=Cc2ccccc21 | 10.1021/jm040768k | |||
CHEMBL364845 | 132667 | 0 | None | 1 | 2 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 292 | 2 | 1 | 2 | 3.0 | CC(=O)NCC(=O)N1c2ccccc2C=Cc2ccccc21 | 10.1021/jm040768k | |||
139451776 | 191790 | 0 | None | -5 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 277 | 6 | 1 | 5 | 1.6 | COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1 | 10.1021/acs.jmedchem.0c00627 | |||
CHEMBL4854836 | 191790 | 0 | None | -5 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 277 | 6 | 1 | 5 | 1.6 | COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1 | 10.1021/acs.jmedchem.0c00627 | |||
127025781 | 144602 | 0 | None | 6 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 309 | 5 | 1 | 3 | 3.7 | COc1ccc2ccc3oc(CCNC(=O)C4CC4)cc3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL3759859 | 144602 | 0 | None | 6 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 309 | 5 | 1 | 3 | 3.7 | COc1ccc2ccc3oc(CCNC(=O)C4CC4)cc3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
18007985 | 15488 | 0 | None | -10 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 538 | 14 | 2 | 4 | 6.0 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
CHEMBL1095832 | 15488 | 0 | None | -10 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 538 | 14 | 2 | 4 | 6.0 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
16094582 | 90089 | 5 | None | 44 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 251 | 4 | 1 | 1 | 3.3 | CC(=O)NCC=C(c1ccccc1)c1ccccc1 | 10.1021/jm060850a | |||
CHEMBL219076 | 90089 | 5 | None | 44 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 251 | 4 | 1 | 1 | 3.3 | CC(=O)NCC=C(c1ccccc1)c1ccccc1 | 10.1021/jm060850a | |||
16743295 | 99964 | 0 | None | 3 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 284 | 6 | 1 | 2 | 3.4 | CCCC(=O)NCCCc1cn2c3c(cccc13)CCC2 | 10.1016/j.ejmech.2007.01.005 | |||
CHEMBL244472 | 99964 | 0 | None | 3 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 284 | 6 | 1 | 2 | 3.4 | CCCC(=O)NCCCc1cn2c3c(cccc13)CCC2 | 10.1016/j.ejmech.2007.01.005 | |||
9860588 | 26718 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 283 | 4 | 1 | 2 | 3.4 | COc1ccc2cccc3c2c1CCC3CCNC(C)=O | 10.1021/jm000922c | |||
CHEMBL130286 | 26718 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 283 | 4 | 1 | 2 | 3.4 | COc1ccc2cccc3c2c1CCC3CCNC(C)=O | 10.1021/jm000922c | |||
46888492 | 15615 | 0 | None | -18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 564 | 14 | 2 | 5 | 6.5 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)c5ccco5)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
CHEMBL1096991 | 15615 | 0 | None | -18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 564 | 14 | 2 | 5 | 6.5 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)c5ccco5)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
44264964 | 212045 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 281 | 5 | 1 | 3 | 3.4 | C#CCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7898 | 212045 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 281 | 5 | 1 | 3 | 3.4 | C#CCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
130400672 | 163775 | 0 | None | 3 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 204 | 2 | 2 | 2 | 1.4 | CC(=O)NCC1CNc2ccccc2C1 | 10.1021/acs.jmedchem.8b00359 | |||
CHEMBL4073210 | 163775 | 0 | None | 3 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 204 | 2 | 2 | 2 | 1.4 | CC(=O)NCC1CNc2ccccc2C1 | 10.1021/acs.jmedchem.8b00359 | |||
162673578 | 189897 | 0 | None | 5 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 272 | 5 | 2 | 5 | 2.4 | CNc1nnc(CCc2c[nH]c3ccc(OC)cc23)o1 | 10.1016/j.ejmech.2020.112090 | |||
CHEMBL4794879 | 189897 | 0 | None | 5 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 272 | 5 | 2 | 5 | 2.4 | CNc1nnc(CCc2c[nH]c3ccc(OC)cc23)o1 | 10.1016/j.ejmech.2020.112090 | |||
1362 | 10210 | 22 | None | -39 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 498 | 12 | 2 | 4 | 5.2 | CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1021/jm0255872 | |||
9870523 | 10210 | 22 | None | -39 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 498 | 12 | 2 | 4 | 5.2 | CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1021/jm0255872 | |||
CHEMBL429392 | 10210 | 22 | None | -39 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 498 | 12 | 2 | 4 | 5.2 | CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1021/jm0255872 | |||
1362 | 10210 | 22 | None | -39 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 498 | 12 | 2 | 4 | 5.2 | CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1021/jm401343c | |||
9870523 | 10210 | 22 | None | -39 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 498 | 12 | 2 | 4 | 5.2 | CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1021/jm401343c | |||
CHEMBL429392 | 10210 | 22 | None | -39 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 498 | 12 | 2 | 4 | 5.2 | CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1021/jm401343c | |||
1362 | 10210 | 22 | None | -39 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 498 | 12 | 2 | 4 | 5.2 | CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1039/C5MD00190K | |||
9870523 | 10210 | 22 | None | -39 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 498 | 12 | 2 | 4 | 5.2 | CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1039/C5MD00190K | |||
CHEMBL429392 | 10210 | 22 | None | -39 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 498 | 12 | 2 | 4 | 5.2 | CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1039/C5MD00190K | |||
10544425 | 215116 | 0 | None | 1 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 330 | 4 | 1 | 2 | 4.1 | O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CCC1 | 10.1021/jm980684+ | |||
CHEMBL9934 | 215116 | 0 | None | 1 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 330 | 4 | 1 | 2 | 4.1 | O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CCC1 | 10.1021/jm980684+ | |||
44349270 | 119869 | 0 | None | -3 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 286 | 6 | 1 | 3 | 3.4 | CC(C)c1nc2cccc(CCCNC(=O)C3CC3)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL331317 | 119869 | 0 | None | -3 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 286 | 6 | 1 | 3 | 3.4 | CC(C)c1nc2cccc(CCCNC(=O)C3CC3)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
10893437 | 215228 | 0 | None | 6 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 348 | 6 | 1 | 3 | 4.1 | COc1cccc2c1cc(CCNC(=O)C1CCC1)n2-c1ccccc1 | 10.1021/jm001125h | |||
CHEMBL99987 | 215228 | 0 | None | 6 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 348 | 6 | 1 | 3 | 4.1 | COc1cccc2c1cc(CCNC(=O)C1CCC1)n2-c1ccccc1 | 10.1021/jm001125h | |||
12436515 | 22604 | 2 | None | 1 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 193 | 4 | 1 | 2 | 1.6 | CC(=O)NCC(C)Oc1ccccc1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1222985 | 22604 | 2 | None | 1 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 193 | 4 | 1 | 2 | 1.6 | CC(=O)NCC(C)Oc1ccccc1 | 10.1016/j.bmc.2010.06.100 | |||
86079062 | 187511 | 0 | None | 1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 245 | 4 | 1 | 4 | 1.3 | COc1ccc2ncnc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2020.112078 | |||
CHEMBL4755860 | 187511 | 0 | None | 1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 245 | 4 | 1 | 4 | 1.3 | COc1ccc2ncnc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2020.112078 | |||
10666373 | 105097 | 0 | None | 4 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.3 | CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1 | 10.1021/jm980684+ | |||
CHEMBL274995 | 105097 | 0 | None | 4 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 362 | 5 | 1 | 3 | 4.3 | CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1 | 10.1021/jm980684+ | |||
19703063 | 35688 | 1 | None | -2 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 233 | 4 | 2 | 3 | 1.2 | COc1c[nH]c2ncc(CCNC(C)=O)c-2c1 | 10.1016/j.bmcl.2011.02.097 | |||
CHEMBL137969 | 35688 | 1 | None | -2 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 233 | 4 | 2 | 3 | 1.2 | COc1c[nH]c2ncc(CCNC(C)=O)c-2c1 | 10.1016/j.bmcl.2011.02.097 | |||
19703063 | 35688 | 1 | None | -2 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 233 | 4 | 2 | 3 | 1.2 | COc1c[nH]c2ncc(CCNC(C)=O)c-2c1 | 10.1016/j.ejmech.2016.01.008 | |||
CHEMBL137969 | 35688 | 1 | None | -2 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 233 | 4 | 2 | 3 | 1.2 | COc1c[nH]c2ncc(CCNC(C)=O)c-2c1 | 10.1016/j.ejmech.2016.01.008 | |||
25210135 | 181703 | 0 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 378 | 6 | 3 | 4 | 3.0 | COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
CHEMBL456505 | 181703 | 0 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 378 | 6 | 3 | 4 | 3.0 | COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
25210135 | 181703 | 0 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 378 | 6 | 3 | 4 | 3.0 | COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
CHEMBL456505 | 181703 | 0 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 378 | 6 | 3 | 4 | 3.0 | COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
44349171 | 23427 | 1 | None | 6 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 275 | 6 | 2 | 3 | 2.6 | CCNC(=O)NCCCc1cccc2nc(CC)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL124217 | 23427 | 1 | None | 6 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 275 | 6 | 2 | 3 | 2.6 | CCNC(=O)NCCCc1cccc2nc(CC)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
10738183 | 11149 | 0 | None | 41 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 374 | 5 | 1 | 3 | 4.3 | COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1 | 10.1021/jm980684+ | |||
CHEMBL10124 | 11149 | 0 | None | 41 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 374 | 5 | 1 | 3 | 4.3 | COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1 | 10.1021/jm980684+ | |||
10591657 | 11448 | 0 | None | 14 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 318 | 5 | 1 | 2 | 4.1 | CCCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2 | 10.1021/jm980684+ | |||
CHEMBL10328 | 11448 | 0 | None | 14 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 318 | 5 | 1 | 2 | 4.1 | CCCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2 | 10.1021/jm980684+ | |||
162674428 | 190059 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 273 | 4 | 2 | 4 | 2.2 | COc1ccc2[nH]cc(CC(C)c3n[nH]c(=O)o3)c2c1 | 10.1016/j.ejmech.2020.112090 | |||
CHEMBL4796759 | 190059 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 273 | 4 | 2 | 4 | 2.2 | COc1ccc2[nH]cc(CC(C)c3n[nH]c(=O)o3)c2c1 | 10.1016/j.ejmech.2020.112090 | |||
44436051 | 158142 | 6 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 209 | 5 | 1 | 3 | 1.2 | COc1cccc(OCCNC(C)=O)c1 | 10.1021/jm700957j | |||
CHEMBL396132 | 158142 | 6 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 209 | 5 | 1 | 3 | 1.2 | COc1cccc(OCCNC(C)=O)c1 | 10.1021/jm700957j | |||
44272424 | 75850 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 289 | 4 | 3 | 3 | 2.5 | CNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL19237 | 75850 | 0 | None | -1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 289 | 4 | 3 | 3 | 2.5 | CNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 | 10.1016/j.bmcl.2003.12.052 | |||
46884598 | 14962 | 0 | None | 20 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 223 | 5 | 2 | 3 | 1.5 | COc1cc(CCCNC(C)=O)ccc1O | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL1092047 | 14962 | 0 | None | 20 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 223 | 5 | 2 | 3 | 1.5 | COc1cc(CCCNC(C)=O)ccc1O | 10.1016/j.bmcl.2010.02.084 | |||
9930390 | 214659 | 0 | None | 6 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 391 | 6 | 1 | 3 | 5.0 | COc1ccc2oc(Cc3c(Cl)cccc3Cl)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
CHEMBL96562 | 214659 | 0 | None | 6 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 391 | 6 | 1 | 3 | 5.0 | COc1ccc2oc(Cc3c(Cl)cccc3Cl)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
10991315 | 215074 | 0 | None | 23 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 336 | 7 | 1 | 3 | 4.1 | CCC(=O)NCCCc1cc2c(OC)cccc2n1-c1ccccc1 | 10.1021/jm001125h | |||
CHEMBL99001 | 215074 | 0 | None | 23 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 336 | 7 | 1 | 3 | 4.1 | CCC(=O)NCCCc1cc2c(OC)cccc2n1-c1ccccc1 | 10.1021/jm001125h | |||
49865268 | 22649 | 0 | None | -13 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 249 | 6 | 1 | 3 | 2.0 | COc1cccc(OC(C)CNC(=O)C2CC2)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223128 | 22649 | 0 | None | -13 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 249 | 6 | 1 | 3 | 2.0 | COc1cccc(OC(C)CNC(=O)C2CC2)c1 | 10.1016/j.bmc.2010.06.100 | |||
44358088 | 33554 | 0 | None | 1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 246 | 2 | 1 | 3 | 1.3 | CC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL136273 | 33554 | 0 | None | 1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 246 | 2 | 1 | 3 | 1.3 | CC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
46884555 | 15114 | 0 | None | 16 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 327 | 9 | 1 | 3 | 3.7 | CCC(=O)NCCCc1ccc(OCc2ccccc2)c(OC)c1 | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL1092911 | 15114 | 0 | None | 16 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 327 | 9 | 1 | 3 | 3.7 | CCC(=O)NCCCc1ccc(OCc2ccccc2)c(OC)c1 | 10.1016/j.bmcl.2010.02.084 | |||
9903953 | 211816 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 285 | 5 | 1 | 3 | 4.1 | COc1cccc(Oc2ccc(NC(=O)C(C)C)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7703 | 211816 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 285 | 5 | 1 | 3 | 4.1 | COc1cccc(Oc2ccc(NC(=O)C(C)C)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
10705590 | 214986 | 0 | None | 1 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 246 | 4 | 1 | 3 | 1.9 | COc1ccc2cc(CCNC(C)=O)n(C)c2c1 | 10.1021/jm001125h | |||
CHEMBL98484 | 214986 | 0 | None | 1 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 246 | 4 | 1 | 3 | 1.9 | COc1ccc2cc(CCNC(C)=O)n(C)c2c1 | 10.1021/jm001125h | |||
49865377 | 22706 | 0 | None | -1 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 239 | 5 | 1 | 3 | 2.3 | COc1cccc(SC[C@@H](C)NC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223280 | 22706 | 0 | None | -1 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 239 | 5 | 1 | 3 | 2.3 | COc1cccc(SC[C@@H](C)NC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
11403195 | 130457 | 1 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 278 | 3 | 1 | 2 | 3.4 | CC(=O)NCCN1c2ccccc2C=Cc2ccccc21 | 10.1021/jm040768k | |||
CHEMBL362133 | 130457 | 1 | None | -1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 278 | 3 | 1 | 2 | 3.4 | CC(=O)NCCN1c2ccccc2C=Cc2ccccc21 | 10.1021/jm040768k | |||
49865147 | 22602 | 2 | None | 3 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 223 | 5 | 1 | 3 | 1.6 | COc1ccc(OC(C)CNC(C)=O)cc1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1222983 | 22602 | 2 | None | 3 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 223 | 5 | 1 | 3 | 1.6 | COc1ccc(OC(C)CNC(C)=O)cc1 | 10.1016/j.bmc.2010.06.100 | |||
44412078 | 146295 | 0 | None | 1 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 272 | 3 | 2 | 3 | 2.4 | CC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1 | 10.1021/jm0512544 | |||
CHEMBL379504 | 146295 | 0 | None | 1 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 272 | 3 | 2 | 3 | 2.4 | CC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1 | 10.1021/jm0512544 | |||
18522208 | 134064 | 0 | None | -6 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 349 | 9 | 1 | 2 | 5.1 | CC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL365852 | 134064 | 0 | None | -6 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 349 | 9 | 1 | 2 | 5.1 | CC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
145974583 | 171269 | 0 | None | -4 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 279 | 9 | 2 | 4 | 1.4 | CC(=O)NCCN(C)c1cccc(OCCCCN)c1 | 10.1021/acs.jmedchem.8b00893 | |||
CHEMBL4214348 | 171269 | 0 | None | -4 | 2 | Human | 4.9 | pKi | = | 4.9 | Binding | ChEMBL | 279 | 9 | 2 | 4 | 1.4 | CC(=O)NCCN(C)c1cccc(OCCCCN)c1 | 10.1021/acs.jmedchem.8b00893 | |||
18702059 | 211776 | 4 | None | 7 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 283 | 5 | 1 | 3 | 3.8 | COc1cccc(Oc2ccc(NC(=O)C3CC3)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7673 | 211776 | 4 | None | 7 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 283 | 5 | 1 | 3 | 3.8 | COc1cccc(Oc2ccc(NC(=O)C3CC3)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
16094583 | 172919 | 3 | None | 69 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 291 | 5 | 1 | 1 | 4.0 | O=C(NCC=C(c1ccccc1)c1ccccc1)C1CCC1 | 10.1021/jm060850a | |||
CHEMBL426168 | 172919 | 3 | None | 69 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 291 | 5 | 1 | 1 | 4.0 | O=C(NCC=C(c1ccccc1)c1ccccc1)C1CCC1 | 10.1021/jm060850a | |||
10542922 | 123370 | 0 | None | -6 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 309 | 5 | 1 | 2 | 3.8 | COc1ccc2cccc3c2c1CCC3CCNC(=O)C1CC1 | 10.1021/jm000922c | |||
CHEMBL336633 | 123370 | 0 | None | -6 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 309 | 5 | 1 | 2 | 3.8 | COc1ccc2cccc3c2c1CCC3CCNC(=O)C1CC1 | 10.1021/jm000922c | |||
127026426 | 144578 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 309 | 5 | 1 | 3 | 3.7 | COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL3759606 | 144578 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 309 | 5 | 1 | 3 | 3.7 | COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
46885286 | 14940 | 0 | None | 218 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 327 | 9 | 1 | 3 | 3.4 | COc1ccc(OCCc2ccccc2)c(CCCNC(C)=O)c1 | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL1091895 | 14940 | 0 | None | 218 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 327 | 9 | 1 | 3 | 3.4 | COc1ccc(OCCc2ccccc2)c(CCCNC(C)=O)c1 | 10.1016/j.bmcl.2010.02.084 | |||
9850873 | 15639 | 0 | None | -13 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 564 | 15 | 2 | 4 | 6.4 | O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12)C1CC1 | 10.1016/j.bmc.2010.04.008 | |||
CHEMBL1097314 | 15639 | 0 | None | -13 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 564 | 15 | 2 | 4 | 6.4 | O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12)C1CC1 | 10.1016/j.bmc.2010.04.008 | |||
44359437 | 36673 | 0 | None | -1 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 273 | 5 | 2 | 3 | 2.1 | COc1ccc2cccc(C(CO)CNC(C)=O)c2c1 | 10.1039/C4MD00149D | |||
CHEMBL138807 | 36673 | 0 | None | -1 | 3 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 273 | 5 | 2 | 3 | 2.1 | COc1ccc2cccc(C(CO)CNC(C)=O)c2c1 | 10.1039/C4MD00149D | |||
168274836 | 196926 | 0 | None | 3 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 411 | 7 | 1 | 7 | 3.4 | COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | |||
CHEMBL5173623 | 196926 | 0 | None | 3 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 411 | 7 | 1 | 7 | 3.4 | COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | |||
9870683 | 15661 | 0 | None | -9 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 502 | 13 | 2 | 5 | 5.2 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4occ(CCNC(C)=O)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
CHEMBL1097496 | 15661 | 0 | None | -9 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 502 | 13 | 2 | 5 | 5.2 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4occ(CCNC(C)=O)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
9860638 | 212533 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 285 | 6 | 1 | 3 | 4.2 | CCCC(=O)Nc1ccccc1Oc1cccc(OC)c1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL8278 | 212533 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 285 | 6 | 1 | 3 | 4.2 | CCCC(=O)Nc1ccccc1Oc1cccc(OC)c1 | 10.1016/j.bmcl.2003.11.030 | |||
49865376 | 22705 | 2 | None | 9 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 239 | 5 | 1 | 3 | 2.3 | COc1cccc(SCC(C)NC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223279 | 22705 | 2 | None | 9 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 239 | 5 | 1 | 3 | 2.3 | COc1cccc(SCC(C)NC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
10447987 | 123747 | 2 | None | 1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 308 | 5 | 1 | 3 | 3.3 | COc1ccc2c(c1)c(CCNC(C)=O)cn2-c1ccccc1 | 10.1021/jm020982d | |||
CHEMBL33869 | 123747 | 2 | None | 1 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 308 | 5 | 1 | 3 | 3.3 | COc1ccc2c(c1)c(CCNC(C)=O)cn2-c1ccccc1 | 10.1021/jm020982d | |||
162663385 | 188777 | 0 | None | 2 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 271 | 5 | 1 | 4 | 1.7 | COc1ccc2cnnc(CCNC(=O)C3CC3)c2c1 | 10.1016/j.ejmech.2020.112078 | |||
CHEMBL4780509 | 188777 | 0 | None | 2 | 2 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 271 | 5 | 1 | 4 | 1.7 | COc1ccc2cnnc(CCNC(=O)C3CC3)c2c1 | 10.1016/j.ejmech.2020.112078 | |||
11573203 | 147856 | 0 | None | 2 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 312 | 5 | 1 | 3 | 3.1 | COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCC1)cn2C | 10.1021/jm0512544 | |||
CHEMBL382579 | 147856 | 0 | None | 2 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 312 | 5 | 1 | 3 | 3.1 | COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCC1)cn2C | 10.1021/jm0512544 | |||
10361427 | 119648 | 0 | None | -18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 364 | 10 | 1 | 3 | 4.9 | CCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL330969 | 119648 | 0 | None | -18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 364 | 10 | 1 | 3 | 4.9 | CCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
25209860 | 195762 | 0 | None | 10 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 377 | 6 | 2 | 3 | 3.8 | COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
CHEMBL508552 | 195762 | 0 | None | 10 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 377 | 6 | 2 | 3 | 3.8 | COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
44394532 | 74020 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 376 | 7 | 1 | 3 | 4.7 | CC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL188016 | 74020 | 0 | None | 1 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 376 | 7 | 1 | 3 | 4.7 | CC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 | 10.1016/j.bmcl.2004.07.055 | |||
25209860 | 195762 | 0 | None | 10 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 377 | 6 | 2 | 3 | 3.8 | COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
CHEMBL508552 | 195762 | 0 | None | 10 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 377 | 6 | 2 | 3 | 3.8 | COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
44424017 | 92098 | 0 | None | -1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 592 | 14 | 4 | 8 | 3.4 | COc1ccc2[nH]c(C(=O)OCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
CHEMBL226112 | 92098 | 0 | None | -1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 592 | 14 | 4 | 8 | 3.4 | COc1ccc2[nH]c(C(=O)OCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
127041170 | 143467 | 0 | None | -1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 584 | 15 | 2 | 4 | 6.1 | O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F | 10.1039/C5MD00190K | |||
CHEMBL3740377 | 143467 | 0 | None | -1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 584 | 15 | 2 | 4 | 6.1 | O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F | 10.1039/C5MD00190K | |||
25210131 | 182094 | 0 | None | 2 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 377 | 7 | 2 | 3 | 3.8 | CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12 | 10.1021/jm800974d | |||
CHEMBL457352 | 182094 | 0 | None | 2 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 377 | 7 | 2 | 3 | 3.8 | CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12 | 10.1021/jm800974d | |||
25210131 | 182094 | 0 | None | 2 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 377 | 7 | 2 | 3 | 3.8 | CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12 | 10.1021/jm800974d | |||
CHEMBL457352 | 182094 | 0 | None | 2 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 377 | 7 | 2 | 3 | 3.8 | CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12 | 10.1021/jm800974d | |||
25210133 | 196340 | 0 | None | 2 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 377 | 6 | 2 | 3 | 3.7 | COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
CHEMBL514427 | 196340 | 0 | None | 2 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 377 | 6 | 2 | 3 | 3.7 | COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
11058163 | 214993 | 0 | None | 22 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 386 | 5 | 1 | 3 | 4.1 | COc1cccc2c1c(Br)c(CNC(C)=O)n2Cc1ccccc1 | 10.1021/jm001125h | |||
CHEMBL98520 | 214993 | 0 | None | 22 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 386 | 5 | 1 | 3 | 4.1 | COc1cccc2c1c(Br)c(CNC(C)=O)n2Cc1ccccc1 | 10.1021/jm001125h | |||
5151463 | 90108 | 12 | None | 29 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 253 | 5 | 1 | 1 | 3.3 | CC(=O)NCCC(c1ccccc1)c1ccccc1 | 10.1021/jm060850a | |||
CHEMBL219177 | 90108 | 12 | None | 29 | 2 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 253 | 5 | 1 | 1 | 3.3 | CC(=O)NCCC(c1ccccc1)c1ccccc1 | 10.1021/jm060850a | |||
10903463 | 215143 | 0 | None | -2 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 324 | 5 | 2 | 2 | 3.0 | CCC(=O)NCCc1[nH]c2cccc(OC)c2c1Br | 10.1021/jm001125h | |||
CHEMBL99502 | 215143 | 0 | None | -2 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 324 | 5 | 2 | 2 | 3.0 | CCC(=O)NCCc1[nH]c2cccc(OC)c2c1Br | 10.1021/jm001125h | |||
44412063 | 84363 | 0 | None | -2 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 298 | 4 | 2 | 3 | 2.8 | Cn1cc(C2(CNC(=O)C3CC3)CCC2)c2cc(O)ccc21 | 10.1021/jm0512544 | |||
CHEMBL208802 | 84363 | 0 | None | -2 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 298 | 4 | 2 | 3 | 2.8 | Cn1cc(C2(CNC(=O)C3CC3)CCC2)c2cc(O)ccc21 | 10.1021/jm0512544 | |||
10609620 | 215088 | 1 | None | 5 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2cc(CCNC(C)=O)[nH]c2c1 | 10.1021/jm001125h | |||
CHEMBL99091 | 215088 | 1 | None | 5 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2cc(CCNC(C)=O)[nH]c2c1 | 10.1021/jm001125h | |||
16094578 | 90047 | 1 | None | 8 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 251 | 4 | 1 | 1 | 3.4 | CC(=O)NC/C(=C\c1ccccc1)c1ccccc1 | 10.1021/jm060850a | |||
CHEMBL218808 | 90047 | 1 | None | 8 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 251 | 4 | 1 | 1 | 3.4 | CC(=O)NC/C(=C\c1ccccc1)c1ccccc1 | 10.1021/jm060850a | |||
25210132 | 177656 | 0 | None | 9 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 403 | 7 | 2 | 3 | 4.2 | COc1ccc2[nH]c(CN3CCc4ccccc43)c(CCNC(=O)C3CCC3)c2c1 | 10.1021/jm800974d | |||
CHEMBL445427 | 177656 | 0 | None | 9 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 403 | 7 | 2 | 3 | 4.2 | COc1ccc2[nH]c(CN3CCc4ccccc43)c(CCNC(=O)C3CCC3)c2c1 | 10.1021/jm800974d | |||
1362 | 10210 | 22 | None | -39 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 498 | 12 | 2 | 4 | 5.2 | CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1021/jm401343c | |||
9870523 | 10210 | 22 | None | -39 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 498 | 12 | 2 | 4 | 5.2 | CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1021/jm401343c | |||
CHEMBL429392 | 10210 | 22 | None | -39 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 498 | 12 | 2 | 4 | 5.2 | CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1021/jm401343c | |||
22718585 | 23278 | 0 | None | 9 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 274 | 6 | 1 | 3 | 3.4 | CCC(=O)NCCCc1cccc2nc(C(C)C)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL123634 | 23278 | 0 | None | 9 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 274 | 6 | 1 | 3 | 3.4 | CCC(=O)NCCCc1cccc2nc(C(C)C)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
44264950 | 211825 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 299 | 6 | 1 | 3 | 4.5 | COc1cccc(Oc2ccc(NC(=O)CC(C)C)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7708 | 211825 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 299 | 6 | 1 | 3 | 4.5 | COc1cccc(Oc2ccc(NC(=O)CC(C)C)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
137653199 | 165402 | 0 | None | 5 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 218 | 2 | 1 | 2 | 1.4 | CC(=O)NCC1Cc2ccccc2N(C)C1 | 10.1021/acs.jmedchem.8b00359 | |||
CHEMBL4092308 | 165402 | 0 | None | 5 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 218 | 2 | 1 | 2 | 1.4 | CC(=O)NCC1Cc2ccccc2N(C)C1 | 10.1021/acs.jmedchem.8b00359 | |||
127041170 | 143467 | 0 | None | -1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 584 | 15 | 2 | 4 | 6.1 | O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F | 10.1039/C5MD00190K | |||
CHEMBL3740377 | 143467 | 0 | None | -1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 584 | 15 | 2 | 4 | 6.1 | O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F | 10.1039/C5MD00190K | |||
127026425 | 144598 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 295 | 4 | 1 | 3 | 3.6 | COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL3759816 | 144598 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 295 | 4 | 1 | 3 | 3.6 | COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
25210133 | 196340 | 0 | None | 2 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 377 | 6 | 2 | 3 | 3.7 | COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
CHEMBL514427 | 196340 | 0 | None | 2 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 377 | 6 | 2 | 3 | 3.7 | COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
71540393 | 93188 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 226 | 2 | 2 | 1 | 2.7 | CNC(=O)N/C=C/c1cccc2ccccc12 | 10.1016/j.bmcl.2012.11.069 | |||
CHEMBL2314254 | 93188 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 226 | 2 | 2 | 1 | 2.7 | CNC(=O)N/C=C/c1cccc2ccccc12 | 10.1016/j.bmcl.2012.11.069 | |||
44424021 | 148869 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 690 | 21 | 4 | 8 | 6.2 | COc1ccc2[nH]c(C(=O)OCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
CHEMBL388141 | 148869 | 0 | None | 1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 690 | 21 | 4 | 8 | 6.2 | COc1ccc2[nH]c(C(=O)OCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
145969866 | 171620 | 0 | None | 2 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 546 | 15 | 3 | 6 | 4.8 | CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
CHEMBL4218897 | 171620 | 0 | None | 2 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 546 | 15 | 3 | 6 | 4.8 | CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
162644724 | 186173 | 0 | None | 57 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 321 | 5 | 1 | 4 | 3.0 | COc1ccc2nc(-c3ccccc3)nc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2020.112078 | |||
CHEMBL4739898 | 186173 | 0 | None | 57 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 321 | 5 | 1 | 4 | 3.0 | COc1ccc2nc(-c3ccccc3)nc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2020.112078 | |||
44264965 | 212118 | 1 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 286 | 5 | 2 | 4 | 4.0 | CCOC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7959 | 212118 | 1 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 286 | 5 | 2 | 4 | 4.0 | CCOC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
44394556 | 131003 | 0 | None | -3 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 402 | 8 | 1 | 3 | 5.1 | O=C(N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1)C1CC1 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL363441 | 131003 | 0 | None | -3 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 402 | 8 | 1 | 3 | 5.1 | O=C(N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1)C1CC1 | 10.1016/j.bmcl.2004.07.055 | |||
56671857 | 71227 | 0 | None | -10 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 384 | 13 | 1 | 4 | 4.3 | CC(=O)NCCN(C)c1cccc(OCCCCCCOc2ccccc2)c1 | 10.1016/j.bmc.2011.06.063 | |||
CHEMBL1813324 | 71227 | 0 | None | -10 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 384 | 13 | 1 | 4 | 4.3 | CC(=O)NCCN(C)c1cccc(OCCCCCCOc2ccccc2)c1 | 10.1016/j.bmc.2011.06.063 | |||
22718619 | 23546 | 0 | None | 7 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 288 | 7 | 1 | 3 | 3.8 | CCCC(=O)NCCCc1cccc2nc(C(C)C)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL124445 | 23546 | 0 | None | 7 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 288 | 7 | 1 | 3 | 3.8 | CCCC(=O)NCCCc1cccc2nc(C(C)C)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
10089253 | 123863 | 0 | None | -12 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 350 | 9 | 1 | 3 | 4.5 | CC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL339265 | 123863 | 0 | None | -12 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 350 | 9 | 1 | 3 | 4.5 | CC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
145 | 6928 | 49 | None | -3 | 30 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | |||
1832 | 6928 | 49 | None | -3 | 30 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | |||
CHEMBL7257 | 6928 | 49 | None | -3 | 30 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | |||
DB14010 | 6928 | 49 | None | -3 | 30 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/acs.jmedchem.5b00245 | |||
122178507 | 128102 | 0 | None | 13 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 243 | 3 | 1 | 4 | 2.5 | COc1ccc2[nH]cc(Cc3nnc(C)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
CHEMBL3580915 | 128102 | 0 | None | 13 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 243 | 3 | 1 | 4 | 2.5 | COc1ccc2[nH]cc(Cc3nnc(C)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
44317822 | 111653 | 0 | None | -1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 315 | 8 | 1 | 3 | 3.7 | CCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC | 10.1016/S0960-894X(97)00444-7 | |||
CHEMBL311106 | 111653 | 0 | None | -1 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 315 | 8 | 1 | 3 | 3.7 | CCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC | 10.1016/S0960-894X(97)00444-7 | |||
10801655 | 28147 | 0 | None | -2 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 265 | 4 | 1 | 1 | 3.4 | O=C(NCCC1Cc2cccc3cccc1c23)C1CC1 | 10.1021/jm000922c | |||
CHEMBL131431 | 28147 | 0 | None | -2 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 265 | 4 | 1 | 1 | 3.4 | O=C(NCCC1Cc2cccc3cccc1c23)C1CC1 | 10.1021/jm000922c | |||
18360658 | 15662 | 0 | None | -4 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 518 | 13 | 2 | 5 | 5.7 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
CHEMBL1097497 | 15662 | 0 | None | -4 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 518 | 13 | 2 | 5 | 5.7 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
86272990 | 128105 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 245 | 3 | 2 | 4 | 1.4 | COc1ccc2[nH]cc(Cc3n[nH]c(=O)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
CHEMBL3580918 | 128105 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 245 | 3 | 2 | 4 | 1.4 | COc1ccc2[nH]cc(Cc3n[nH]c(=O)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
44394478 | 73063 | 0 | None | -1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 404 | 8 | 1 | 3 | 5.3 | CC(C)C(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL184762 | 73063 | 0 | None | -1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 404 | 8 | 1 | 3 | 5.3 | CC(C)C(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 | 10.1016/j.bmcl.2004.07.055 | |||
10465460 | 215085 | 2 | None | 1 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 202 | 3 | 2 | 1 | 1.8 | CC(=O)NCCc1cc2ccccc2[nH]1 | 10.1021/jm001125h | |||
CHEMBL99083 | 215085 | 2 | None | 1 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 202 | 3 | 2 | 1 | 1.8 | CC(=O)NCCc1cc2ccccc2[nH]1 | 10.1021/jm001125h | |||
1355 | 10211 | 5 | None | -70 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1021/jm401343c | |||
9806449 | 10211 | 5 | None | -70 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1021/jm401343c | |||
CHEMBL14453 | 10211 | 5 | None | -70 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1021/jm401343c | |||
16105169 | 181456 | 0 | None | -1 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 345 | 3 | 1 | 3 | 3.3 | CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2 | 10.1016/j.bmc.2009.04.068 | |||
CHEMBL455909 | 181456 | 0 | None | -1 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 345 | 3 | 1 | 3 | 3.3 | CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2 | 10.1016/j.bmc.2009.04.068 | |||
22718596 | 124151 | 0 | None | 3 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 322 | 7 | 1 | 3 | 4.3 | CCCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL339784 | 124151 | 0 | None | 3 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 322 | 7 | 1 | 3 | 4.3 | CCCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
11078652 | 214697 | 0 | None | 16 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 351 | 7 | 1 | 3 | 4.3 | CCc1ccc2oc(Cc3cccc(OC)c3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
CHEMBL96778 | 214697 | 0 | None | 16 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 351 | 7 | 1 | 3 | 4.3 | CCc1ccc2oc(Cc3cccc(OC)c3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
10517621 | 214843 | 0 | None | 11 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 290 | 3 | 1 | 2 | 3.3 | CC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2 | 10.1021/jm980684+ | |||
CHEMBL9765 | 214843 | 0 | None | 11 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 290 | 3 | 1 | 2 | 3.3 | CC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2 | 10.1021/jm980684+ | |||
122178513 | 128111 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 288 | 5 | 2 | 5 | 3.1 | CCNc1nnc(Cc2c[nH]c3ccc(OC)cc23)s1 | 10.1021/acs.jmedchem.5b00245 | |||
CHEMBL3580926 | 128111 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 288 | 5 | 2 | 5 | 3.1 | CCNc1nnc(Cc2c[nH]c3ccc(OC)cc23)s1 | 10.1021/acs.jmedchem.5b00245 | |||
16743123 | 99851 | 0 | None | 4 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 270 | 5 | 1 | 2 | 3.0 | CCC(=O)NCCCc1cn2c3c(cccc13)CCC2 | 10.1016/j.ejmech.2007.01.005 | |||
CHEMBL244263 | 99851 | 0 | None | 4 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 270 | 5 | 1 | 2 | 3.0 | CCC(=O)NCCCc1cn2c3c(cccc13)CCC2 | 10.1016/j.ejmech.2007.01.005 | |||
10518621 | 104090 | 0 | None | 11 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 304 | 4 | 1 | 2 | 3.7 | CCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2 | 10.1021/jm980684+ | |||
CHEMBL269175 | 104090 | 0 | None | 11 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 304 | 4 | 1 | 2 | 3.7 | CCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2 | 10.1021/jm980684+ | |||
10640625 | 215075 | 0 | None | 46 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 336 | 7 | 1 | 3 | 3.8 | CCC(=O)NCCc1cc2c(OC)cccc2n1Cc1ccccc1 | 10.1021/jm001125h | |||
CHEMBL99002 | 215075 | 0 | None | 46 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 336 | 7 | 1 | 3 | 3.8 | CCC(=O)NCCc1cc2c(OC)cccc2n1Cc1ccccc1 | 10.1021/jm001125h | |||
16105169 | 181456 | 0 | None | -1 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 345 | 3 | 1 | 3 | 3.3 | CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2 | 10.1016/j.bmc.2009.04.068 | |||
CHEMBL455909 | 181456 | 0 | None | -1 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 345 | 3 | 1 | 3 | 3.3 | CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2 | 10.1016/j.bmc.2009.04.068 | |||
16105169 | 181456 | 0 | None | -1 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 345 | 3 | 1 | 3 | 3.3 | CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2 | 10.1016/j.bmc.2008.07.012 | |||
CHEMBL455909 | 181456 | 0 | None | -1 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 345 | 3 | 1 | 3 | 3.3 | CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2 | 10.1016/j.bmc.2008.07.012 | |||
44412082 | 146057 | 0 | None | -2 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 300 | 5 | 2 | 3 | 3.2 | CCCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1 | 10.1021/jm0512544 | |||
CHEMBL379096 | 146057 | 0 | None | -2 | 2 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 300 | 5 | 2 | 3 | 3.2 | CCCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1 | 10.1021/jm0512544 | |||
10022570 | 175326 | 0 | None | -13 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 378 | 10 | 1 | 3 | 5.1 | CC(C)C(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL435586 | 175326 | 0 | None | -13 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 378 | 10 | 1 | 3 | 5.1 | CC(C)C(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
11131123 | 177412 | 0 | None | 12 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 323 | 6 | 1 | 3 | 3.7 | COc1cccc(Cc2oc3ccccc3c2CCNC(C)=O)c1 | 10.1021/jm0005252 | |||
CHEMBL445117 | 177412 | 0 | None | 12 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 323 | 6 | 1 | 3 | 3.7 | COc1cccc(Cc2oc3ccccc3c2CCNC(C)=O)c1 | 10.1021/jm0005252 | |||
56664925 | 71224 | 0 | None | -53 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 498 | 17 | 2 | 6 | 3.8 | CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 | 10.1016/j.bmc.2011.06.063 | |||
CHEMBL1813321 | 71224 | 0 | None | -53 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 498 | 17 | 2 | 6 | 3.8 | CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 | 10.1016/j.bmc.2011.06.063 | |||
11485537 | 141990 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 370 | 5 | 1 | 4 | 4.0 | CCC(=O)NCc1cc2c(OC)cccc2n1C(=O)c1ccc(Cl)cc1 | 10.1021/jm048956y | |||
CHEMBL372243 | 141990 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 370 | 5 | 1 | 4 | 4.0 | CCC(=O)NCc1cc2c(OC)cccc2n1C(=O)c1ccc(Cl)cc1 | 10.1021/jm048956y | |||
9805364 | 43737 | 0 | None | -89 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 484 | 11 | 2 | 4 | 4.8 | CC(=O)NCCc1cccc2ccc(OCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 | 10.1021/jm0255872 | |||
CHEMBL14514 | 43737 | 0 | None | -89 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 484 | 11 | 2 | 4 | 4.8 | CC(=O)NCCc1cccc2ccc(OCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 | 10.1021/jm0255872 | |||
16743125 | 99078 | 0 | None | 1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 296 | 5 | 1 | 2 | 3.4 | O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CCC1 | 10.1016/j.ejmech.2007.01.005 | |||
CHEMBL242786 | 99078 | 0 | None | 1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 296 | 5 | 1 | 2 | 3.4 | O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CCC1 | 10.1016/j.ejmech.2007.01.005 | |||
44358217 | 34285 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 287 | 3 | 2 | 3 | 1.7 | O=C(NC1CC1)N[C@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL136894 | 34285 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 287 | 3 | 2 | 3 | 1.7 | O=C(NC1CC1)N[C@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
145971624 | 171392 | 0 | None | -1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 517 | 15 | 2 | 5 | 6.0 | CCC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
CHEMBL4215980 | 171392 | 0 | None | -1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 517 | 15 | 2 | 5 | 6.0 | CCC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
10301190 | 15337 | 0 | None | -7 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 511 | 12 | 1 | 5 | 6.2 | COC(=O)c1ccc(-c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc2)cc1 | 10.1016/j.bmc.2010.04.008 | |||
CHEMBL1094545 | 15337 | 0 | None | -7 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 511 | 12 | 1 | 5 | 6.2 | COC(=O)c1ccc(-c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc2)cc1 | 10.1016/j.bmc.2010.04.008 | |||
12004056 | 181001 | 0 | None | -13 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 340 | 6 | 3 | 3 | 2.0 | CC(=O)NCCc1c(Br)[nH]c2ccc(OCCO)cc12 | 10.1016/j.ejmech.2019.111847 | |||
CHEMBL4548591 | 181001 | 0 | None | -13 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 340 | 6 | 3 | 3 | 2.0 | CC(=O)NCCc1c(Br)[nH]c2ccc(OCCO)cc12 | 10.1016/j.ejmech.2019.111847 | |||
81689735 | 128103 | 0 | None | 3 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 257 | 4 | 1 | 4 | 2.7 | COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
CHEMBL3580916 | 128103 | 0 | None | 3 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 257 | 4 | 1 | 4 | 2.7 | COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
118712372 | 120929 | 0 | None | 3 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 308 | 2 | 1 | 2 | 3.4 | CCNC(=O)N1CCCC2Cc3cc(Cl)c(OC)cc3C21 | 10.1016/j.ejmech.2014.09.038 | |||
CHEMBL3329390 | 120929 | 0 | None | 3 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 308 | 2 | 1 | 2 | 3.4 | CCNC(=O)N1CCCC2Cc3cc(Cl)c(OC)cc3C21 | 10.1016/j.ejmech.2014.09.038 | |||
16094577 | 90253 | 4 | None | 2 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 297 | 7 | 1 | 2 | 3.5 | CCC(=O)NCC(Cc1ccccc1)c1cccc(OC)c1 | 10.1021/jm060850a | |||
CHEMBL220136 | 90253 | 4 | None | 2 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 297 | 7 | 1 | 2 | 3.5 | CCC(=O)NCC(Cc1ccccc1)c1cccc(OC)c1 | 10.1021/jm060850a | |||
11418246 | 69177 | 0 | None | 4 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 403 | 6 | 1 | 3 | 5.8 | O=C(NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12)C1CCC1 | 10.1016/j.ejmech.2011.02.044 | |||
CHEMBL1779806 | 69177 | 0 | None | 4 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 403 | 6 | 1 | 3 | 5.8 | O=C(NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12)C1CCC1 | 10.1016/j.ejmech.2011.02.044 | |||
10946222 | 201520 | 0 | None | 43 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 291 | 5 | 1 | 5 | 1.8 | COc1ccc2c(c(CCNC(C)=O)cn2C)c1[N+](=O)[O-] | 10.1021/jm011053+ | |||
CHEMBL53622 | 201520 | 0 | None | 43 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 291 | 5 | 1 | 5 | 1.8 | COc1ccc2c(c(CCNC(C)=O)cn2C)c1[N+](=O)[O-] | 10.1021/jm011053+ | |||
11208632 | 129683 | 1 | None | 2 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 294 | 4 | 1 | 2 | 3.5 | CCC(=O)NCCN1c2ccccc2CCc2ccccc21 | 10.1021/jm040768k | |||
CHEMBL360600 | 129683 | 1 | None | 2 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 294 | 4 | 1 | 2 | 3.5 | CCC(=O)NCCN1c2ccccc2CCc2ccccc21 | 10.1021/jm040768k | |||
11014883 | 214907 | 0 | None | 1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 400 | 6 | 1 | 3 | 4.1 | COc1ccc2c(Br)c(CCNC(C)=O)n(Cc3ccccc3)c2c1 | 10.1021/jm001125h | |||
CHEMBL98028 | 214907 | 0 | None | 1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 400 | 6 | 1 | 3 | 4.1 | COc1ccc2c(Br)c(CCNC(C)=O)n(Cc3ccccc3)c2c1 | 10.1021/jm001125h | |||
90666309 | 116163 | 0 | None | -1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 403 | 7 | 2 | 3 | 4.2 | COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CCC3)c2c1 | 10.1039/C1MD00149C | |||
CHEMBL3219330 | 116163 | 0 | None | -1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 403 | 7 | 2 | 3 | 4.2 | COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CCC3)c2c1 | 10.1039/C1MD00149C | |||
11581340 | 129119 | 0 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 363 | 8 | 1 | 2 | 4.6 | CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
CHEMBL359921 | 129119 | 0 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 363 | 8 | 1 | 2 | 4.6 | CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
20590652 | 136756 | 0 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 391 | 10 | 1 | 2 | 5.4 | CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
CHEMBL367604 | 136756 | 0 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 391 | 10 | 1 | 2 | 5.4 | CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
20590654 | 136948 | 0 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 377 | 9 | 1 | 2 | 5.0 | CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
CHEMBL367797 | 136948 | 0 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 377 | 9 | 1 | 2 | 5.0 | CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
137637884 | 163025 | 0 | None | 10 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 280 | 3 | 1 | 2 | 3.3 | CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | |||
CHEMBL4064813 | 163025 | 0 | None | 10 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 280 | 3 | 1 | 2 | 3.3 | CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | |||
10424693 | 116420 | 1 | None | 2 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 297 | 4 | 1 | 2 | 3.1 | COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1 | 10.1039/C5MD00190K | |||
CHEMBL322339 | 116420 | 1 | None | 2 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 297 | 4 | 1 | 2 | 3.1 | COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1 | 10.1039/C5MD00190K | |||
127038129 | 143650 | 0 | None | 2 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 311 | 5 | 1 | 2 | 3.3 | COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1 | 10.1039/C5MD00190K | |||
CHEMBL3742090 | 143650 | 0 | None | 2 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 311 | 5 | 1 | 2 | 3.3 | COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1 | 10.1039/C5MD00190K | |||
145983175 | 173210 | 0 | None | 3 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 314 | 4 | 2 | 2 | 3.4 | CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4277390 | 173210 | 0 | None | 3 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 314 | 4 | 2 | 2 | 3.4 | CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
145988801 | 173825 | 0 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 283 | 4 | 1 | 2 | 3.4 | COc1ccc2ccc3c(c2c1)C(CCNC(C)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4288925 | 173825 | 0 | None | 1 | 3 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 283 | 4 | 1 | 2 | 3.4 | COc1ccc2ccc3c(c2c1)C(CCNC(C)=O)CC3 | 10.1016/j.ejmech.2017.10.025 | |||
44358231 | 33721 | 0 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 275 | 3 | 2 | 3 | 1.5 | CCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL136431 | 33721 | 0 | None | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 275 | 3 | 2 | 3 | 1.5 | CCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
44264962 | 211629 | 0 | None | 46 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 283 | 5 | 1 | 3 | 4.0 | C/C=C/C(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7559 | 211629 | 0 | None | 46 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 283 | 5 | 1 | 3 | 4.0 | C/C=C/C(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
127025783 | 144516 | 0 | None | 4 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 287 | 4 | 1 | 3 | 3.2 | COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL3759160 | 144516 | 0 | None | 4 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 287 | 4 | 1 | 3 | 3.2 | COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
46885285 | 14939 | 0 | None | 186 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 265 | 8 | 1 | 3 | 2.6 | CCCOc1ccc(OC)cc1CCCNC(C)=O | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL1091894 | 14939 | 0 | None | 186 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 265 | 8 | 1 | 3 | 2.6 | CCCOc1ccc(OC)cc1CCCNC(C)=O | 10.1016/j.bmcl.2010.02.084 | |||
44429451 | 155991 | 0 | None | 15 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 352 | 6 | 1 | 3 | 3.4 | CCCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL394406 | 155991 | 0 | None | 15 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 352 | 6 | 1 | 3 | 3.4 | CCCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
168296374 | 199297 | 0 | None | 2 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 505 | 9 | 1 | 8 | 4.5 | CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1 | 10.1021/acs.jmedchem.2c00717 | |||
CHEMBL5209359 | 199297 | 0 | None | 2 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 505 | 9 | 1 | 8 | 4.5 | CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1 | 10.1021/acs.jmedchem.2c00717 | |||
10038243 | 123739 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 260 | 6 | 1 | 3 | 3.0 | CCCC(=O)NCCCc1cccc2nc(C)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL338659 | 123739 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 260 | 6 | 1 | 3 | 3.0 | CCCC(=O)NCCCc1cccc2nc(C)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
44272425 | 74101 | 0 | None | -3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 300 | 5 | 2 | 3 | 3.1 | CC(C)C1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL18846 | 74101 | 0 | None | -3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 300 | 5 | 2 | 3 | 3.1 | CC(C)C1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1 | 10.1016/j.bmcl.2003.12.052 | |||
44272406 | 75957 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 289 | 5 | 3 | 3 | 2.7 | CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CC)N2 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL19260 | 75957 | 0 | None | 1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 289 | 5 | 3 | 3 | 2.7 | CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CC)N2 | 10.1016/j.bmcl.2003.12.052 | |||
20355585 | 117642 | 6 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 280 | 4 | 2 | 2 | 2.8 | COc1cc2c(CCNC(C)=O)c(C)[nH]c2cc1Cl | 10.1021/jm401343c | |||
CHEMBL3260979 | 117642 | 6 | None | -1 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 280 | 4 | 2 | 2 | 2.8 | COc1cc2c(CCNC(C)=O)c(C)[nH]c2cc1Cl | 10.1021/jm401343c | |||
90666305 | 116159 | 0 | None | 125 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 363 | 6 | 2 | 3 | 3.4 | COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(C)=O)c2c1 | 10.1039/C1MD00149C | |||
CHEMBL3219326 | 116159 | 0 | None | 125 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 363 | 6 | 2 | 3 | 3.4 | COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(C)=O)c2c1 | 10.1039/C1MD00149C | |||
44241666 | 202875 | 0 | None | 6 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 351 | 7 | 2 | 3 | 3.5 | COc1ccc2[nH]c(CN(C)c3ccccc3)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2009.04.068 | |||
CHEMBL560865 | 202875 | 0 | None | 6 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 351 | 7 | 2 | 3 | 3.5 | COc1ccc2[nH]c(CN(C)c3ccccc3)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2009.04.068 | |||
44429450 | 94139 | 0 | None | 6 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 338 | 5 | 1 | 3 | 3.0 | CCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL233310 | 94139 | 0 | None | 6 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 338 | 5 | 1 | 3 | 3.0 | CCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
22718561 | 24027 | 0 | None | 3 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 246 | 5 | 1 | 3 | 2.5 | CCc1nc2cccc(CCCNC(C)=O)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL125665 | 24027 | 0 | None | 3 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 246 | 5 | 1 | 3 | 2.5 | CCc1nc2cccc(CCCNC(C)=O)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
10015474 | 25332 | 0 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 260 | 5 | 1 | 3 | 2.8 | Cc1nc2cccc(CCCNC(=O)C(C)C)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL127596 | 25332 | 0 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 260 | 5 | 1 | 3 | 2.8 | Cc1nc2cccc(CCCNC(=O)C(C)C)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
9893513 | 37734 | 0 | None | -29 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 540 | 15 | 2 | 4 | 6.4 | CC(=O)NCCc1cccc2ccc(OCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 | 10.1021/jm0255872 | |||
CHEMBL13985 | 37734 | 0 | None | -29 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 540 | 15 | 2 | 4 | 6.4 | CC(=O)NCCc1cccc2ccc(OCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 | 10.1021/jm0255872 | |||
10925526 | 119111 | 0 | None | 26 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 329 | 6 | 1 | 3 | 4.2 | COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
CHEMBL329299 | 119111 | 0 | None | 26 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 329 | 6 | 1 | 3 | 4.2 | COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
44272438 | 77084 | 0 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 302 | 5 | 2 | 3 | 3.3 | CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 | 10.1016/j.bmcl.2003.12.052 | |||
CHEMBL19441 | 77084 | 0 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 302 | 5 | 2 | 3 | 3.3 | CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2 | 10.1016/j.bmcl.2003.12.052 | |||
16094584 | 90020 | 0 | None | 33 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 281 | 5 | 1 | 2 | 3.3 | COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1 | 10.1021/jm800974d | |||
CHEMBL218708 | 90020 | 0 | None | 33 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 281 | 5 | 1 | 2 | 3.3 | COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1 | 10.1021/jm800974d | |||
16094593 | 172823 | 0 | None | 91 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 281 | 5 | 1 | 2 | 3.3 | COc1cccc(/C(=C\CNC(C)=O)c2ccccc2)c1 | 10.1021/jm060850a | |||
CHEMBL425644 | 172823 | 0 | None | 91 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 281 | 5 | 1 | 2 | 3.3 | COc1cccc(/C(=C\CNC(C)=O)c2ccccc2)c1 | 10.1021/jm060850a | |||
25270146 | 37466 | 0 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 262 | 5 | 1 | 3 | 2.2 | CCCC(=O)N[C@H]1CCN(c2cccc(OC)c2)C1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL139497 | 37466 | 0 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 262 | 5 | 1 | 3 | 2.2 | CCCC(=O)N[C@H]1CCN(c2cccc(OC)c2)C1 | 10.1016/j.bmcl.2003.09.030 | |||
44358276 | 125750 | 0 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 289 | 4 | 2 | 3 | 1.9 | CCCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL342393 | 125750 | 0 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 289 | 4 | 2 | 3 | 1.9 | CCCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
15453093 | 93186 | 0 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 255 | 3 | 1 | 2 | 2.8 | COc1ccc2ccccc2c1[C@@H]1C[C@H]1NC(C)=O | 10.1016/j.bmcl.2012.11.069 | |||
CHEMBL2314252 | 93186 | 0 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 255 | 3 | 1 | 2 | 2.8 | COc1ccc2ccccc2c1[C@@H]1C[C@H]1NC(C)=O | 10.1016/j.bmcl.2012.11.069 | |||
16094588 | 143500 | 4 | None | 208 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 311 | 8 | 1 | 2 | 4.1 | CCCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1 | 10.1021/jm060850a | |||
CHEMBL374075 | 143500 | 4 | None | 208 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 311 | 8 | 1 | 2 | 4.1 | CCCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1 | 10.1021/jm060850a | |||
44429445 | 94307 | 0 | None | 6 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 274 | 5 | 1 | 3 | 2.6 | CCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL233516 | 94307 | 0 | None | 6 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 274 | 5 | 1 | 3 | 2.6 | CCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
10400294 | 25321 | 0 | None | -3 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 258 | 5 | 1 | 3 | 2.6 | Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL127570 | 25321 | 0 | None | -3 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 258 | 5 | 1 | 3 | 2.6 | Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
11536239 | 83477 | 1 | None | -2 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 260 | 4 | 2 | 2 | 2.6 | COc1ccc2[nH]cc(C(C)(C)CNC(C)=O)c2c1 | 10.1021/jm0512544 | |||
CHEMBL206472 | 83477 | 1 | None | -2 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 260 | 4 | 2 | 2 | 2.6 | COc1ccc2[nH]cc(C(C)(C)CNC(C)=O)c2c1 | 10.1021/jm0512544 | |||
49865321 | 22670 | 0 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 251 | 7 | 1 | 3 | 2.4 | CCCC(=O)NC[C@H](C)Oc1cccc(OC)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223195 | 22670 | 0 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 251 | 7 | 1 | 3 | 2.4 | CCCC(=O)NC[C@H](C)Oc1cccc(OC)c1 | 10.1016/j.bmc.2010.06.100 | |||
11046748 | 214716 | 0 | None | 19 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 365 | 8 | 1 | 4 | 3.9 | C=CC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
CHEMBL96916 | 214716 | 0 | None | 19 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 365 | 8 | 1 | 4 | 3.9 | C=CC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12 | 10.1021/jm0005252 | |||
20642483 | 37425 | 0 | None | -2 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 272 | 3 | 1 | 3 | 1.7 | O=C(N[C@H]1CCN(c2cccc3c2CCO3)C1)C1CC1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL139439 | 37425 | 0 | None | -2 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 272 | 3 | 1 | 3 | 1.7 | O=C(N[C@H]1CCN(c2cccc3c2CCO3)C1)C1CC1 | 10.1016/j.bmcl.2003.09.030 | |||
10332159 | 23566 | 0 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 246 | 5 | 1 | 3 | 2.6 | CCC(=O)NCCCc1cccc2nc(C)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL124577 | 23566 | 0 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 246 | 5 | 1 | 3 | 2.6 | CCC(=O)NCCCc1cccc2nc(C)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
44394438 | 73738 | 0 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 9 | 1 | 2 | 5.6 | CCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL186736 | 73738 | 0 | None | -1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 375 | 9 | 1 | 2 | 5.6 | CCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
11630146 | 84860 | 0 | None | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 246 | 4 | 2 | 2 | 2.4 | COc1ccc2[nH]cc(C(C)CNC(C)=O)c2c1 | 10.1021/jm0512544 | |||
CHEMBL210147 | 84860 | 0 | None | -1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 246 | 4 | 2 | 2 | 2.4 | COc1ccc2[nH]cc(C(C)CNC(C)=O)c2c1 | 10.1021/jm0512544 | |||
23642306 | 165852 | 1 | None | -2 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 287 | 6 | 2 | 3 | 2.5 | CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12 | 10.1039/C4MD00149D | |||
CHEMBL4097233 | 165852 | 1 | None | -2 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 287 | 6 | 2 | 3 | 2.5 | CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12 | 10.1039/C4MD00149D | |||
44389812 | 69776 | 0 | None | -19 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 365 | 10 | 1 | 2 | 4.9 | CCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
CHEMBL178678 | 69776 | 0 | None | -19 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 365 | 10 | 1 | 2 | 4.9 | CCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
44424024 | 91948 | 0 | None | 4 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 522 | 16 | 2 | 6 | 5.6 | COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3ccccc3)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
CHEMBL225301 | 91948 | 0 | None | 4 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 522 | 16 | 2 | 6 | 5.6 | COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3ccccc3)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
49865269 | 22650 | 0 | None | -2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 249 | 6 | 1 | 3 | 2.0 | COc1cccc(O[C@H](C)CNC(=O)C2CC2)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223129 | 22650 | 0 | None | -2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 249 | 6 | 1 | 3 | 2.0 | COc1cccc(O[C@H](C)CNC(=O)C2CC2)c1 | 10.1016/j.bmc.2010.06.100 | |||
16094591 | 90098 | 4 | None | 3 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 283 | 6 | 1 | 2 | 3.2 | COc1cccc(C(CNC(C)=O)Cc2ccccc2)c1 | 10.1021/jm060850a | |||
CHEMBL219127 | 90098 | 4 | None | 3 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 283 | 6 | 1 | 2 | 3.2 | COc1cccc(C(CNC(C)=O)Cc2ccccc2)c1 | 10.1021/jm060850a | |||
56661499 | 71198 | 0 | None | -102 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 456 | 14 | 2 | 6 | 2.7 | CC(=O)NCCN(C)c1cccc(OCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 | 10.1016/j.bmc.2011.06.063 | |||
CHEMBL1813174 | 71198 | 0 | None | -102 | 2 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 456 | 14 | 2 | 6 | 2.7 | CC(=O)NCCN(C)c1cccc(OCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 | 10.1016/j.bmc.2011.06.063 | |||
90666302 | 116156 | 0 | None | 11 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 377 | 6 | 2 | 3 | 3.4 | COc1ccc2[nH]c(CN3CCc4ccccc4C3)c(CCNC(C)=O)c2c1 | 10.1039/C1MD00149C | |||
CHEMBL3219323 | 116156 | 0 | None | 11 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 377 | 6 | 2 | 3 | 3.4 | COc1ccc2[nH]c(CN3CCc4ccccc4C3)c(CCNC(C)=O)c2c1 | 10.1039/C1MD00149C | |||
127038130 | 143401 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 347 | 8 | 1 | 2 | 4.5 | CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12 | 10.1039/C5MD00190K | |||
CHEMBL3739824 | 143401 | 0 | None | 1 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 347 | 8 | 1 | 2 | 4.5 | CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12 | 10.1039/C5MD00190K | |||
85880795 | 117645 | 0 | None | -12 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 319 | 9 | 1 | 3 | 4.0 | CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2 | 10.1021/jm401343c | |||
CHEMBL3260984 | 117645 | 0 | None | -12 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 319 | 9 | 1 | 3 | 4.0 | CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2 | 10.1021/jm401343c | |||
10714573 | 105269 | 0 | None | 12 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 4.7 | CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2CCCc2ccccc2-1 | 10.1021/jm980684+ | |||
CHEMBL276005 | 105269 | 0 | None | 12 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 376 | 6 | 1 | 3 | 4.7 | CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2CCCc2ccccc2-1 | 10.1021/jm980684+ | |||
22718571 | 23610 | 0 | None | 7 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 288 | 8 | 1 | 3 | 3.6 | CCCC(=O)NCCCc1cccc2nc(CCC)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL124782 | 23610 | 0 | None | 7 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 288 | 8 | 1 | 3 | 3.6 | CCCC(=O)NCCCc1cccc2nc(CCC)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
44349100 | 121589 | 0 | None | -34 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 376 | 10 | 1 | 3 | 4.9 | O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL334079 | 121589 | 0 | None | -34 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 376 | 10 | 1 | 3 | 4.9 | O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1 | 10.1016/j.bmcl.2004.04.082 | |||
137640743 | 163824 | 0 | None | 2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 244 | 4 | 1 | 3 | 1.9 | COc1ccc2ccc(CCNC(C)=O)cc2n1 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4073867 | 163824 | 0 | None | 2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 244 | 4 | 1 | 3 | 1.9 | COc1ccc2ccc(CCNC(C)=O)cc2n1 | 10.1016/j.ejmech.2016.12.013 | |||
44349100 | 121589 | 0 | None | -34 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 376 | 10 | 1 | 3 | 4.9 | O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1 | 10.1021/jm401343c | |||
CHEMBL334079 | 121589 | 0 | None | -34 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 376 | 10 | 1 | 3 | 4.9 | O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1 | 10.1021/jm401343c | |||
44357899 | 125459 | 0 | None | 3 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 274 | 4 | 1 | 3 | 2.1 | CCCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL341705 | 125459 | 0 | None | 3 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 274 | 4 | 1 | 3 | 2.1 | CCCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
86272984 | 128110 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 288 | 4 | 2 | 4 | 3.0 | CCn1c(Cc2c[nH]c3ccc(OC)cc23)n[nH]c1=S | 10.1021/acs.jmedchem.5b00245 | |||
CHEMBL3580924 | 128110 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 288 | 4 | 2 | 4 | 3.0 | CCn1c(Cc2c[nH]c3ccc(OC)cc23)n[nH]c1=S | 10.1021/acs.jmedchem.5b00245 | |||
10610443 | 215086 | 0 | None | -1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 246 | 5 | 2 | 2 | 2.2 | CCC(=O)NCCc1cc2c(OC)cccc2[nH]1 | 10.1021/jm001125h | |||
CHEMBL99084 | 215086 | 0 | None | -1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 246 | 5 | 2 | 2 | 2.2 | CCC(=O)NCCc1cc2c(OC)cccc2[nH]1 | 10.1021/jm001125h | |||
45268309 | 203050 | 0 | None | 4 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 303 | 7 | 2 | 3 | 2.3 | CCN(C)Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O | 10.1016/j.bmc.2009.04.068 | |||
CHEMBL561928 | 203050 | 0 | None | 4 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 303 | 7 | 2 | 3 | 2.3 | CCN(C)Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O | 10.1016/j.bmc.2009.04.068 | |||
10567427 | 11012 | 0 | None | 3 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 316 | 4 | 1 | 2 | 3.7 | O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CC1 | 10.1021/jm980684+ | |||
CHEMBL10043 | 11012 | 0 | None | 3 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 316 | 4 | 1 | 2 | 3.7 | O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CC1 | 10.1021/jm980684+ | |||
10853021 | 104913 | 0 | None | 1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 318 | 3 | 1 | 2 | 3.9 | CC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2 | 10.1021/jm980684+ | |||
CHEMBL273623 | 104913 | 0 | None | 1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 318 | 3 | 1 | 2 | 3.9 | CC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2 | 10.1021/jm980684+ | |||
127025786 | 144627 | 0 | None | -1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 312 | 5 | 2 | 3 | 3.5 | CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL3760044 | 144627 | 0 | None | -1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 312 | 5 | 2 | 3 | 3.5 | CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12 | 10.1016/j.ejmech.2015.12.047 | |||
139451784 | 192174 | 0 | None | -6 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 317 | 7 | 1 | 5 | 2.4 | CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1 | 10.1021/acs.jmedchem.0c00627 | |||
CHEMBL4860729 | 192174 | 0 | None | -6 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 317 | 7 | 1 | 5 | 2.4 | CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1 | 10.1021/acs.jmedchem.0c00627 | |||
12985490 | 187999 | 0 | None | 12 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2cc(-c3ccc(CO)cc3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL476132 | 187999 | 0 | None | 12 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2cc(-c3ccc(CO)cc3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
10390684 | 18102 | 0 | None | 4 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 359 | 9 | 1 | 3 | 3.0 | CCC(=O)NCCc1c(OCC[N+](C)(C)C)ccc2ccc(OC)cc12 | 10.1016/S0960-894X(97)00444-7 | |||
CHEMBL1179488 | 18102 | 0 | None | 4 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 359 | 9 | 1 | 3 | 3.0 | CCC(=O)NCCc1c(OCC[N+](C)(C)C)ccc2ccc(OC)cc12 | 10.1016/S0960-894X(97)00444-7 | |||
CHEMBL78338 | 18102 | 0 | None | 4 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 359 | 9 | 1 | 3 | 3.0 | CCC(=O)NCCc1c(OCC[N+](C)(C)C)ccc2ccc(OC)cc12 | 10.1016/S0960-894X(97)00444-7 | |||
10069719 | 200177 | 4 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 403 | 5 | 2 | 4 | 2.4 | COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1[N+](=O)[O-] | 10.1021/jm011053+ | |||
CHEMBL52559 | 200177 | 4 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 403 | 5 | 2 | 4 | 2.4 | COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1[N+](=O)[O-] | 10.1021/jm011053+ | |||
162673916 | 189813 | 0 | None | 2 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 327 | 6 | 1 | 5 | 2.9 | COc1ccc2[nH]cc(CCc3nn(CC4CCC4)c(=O)o3)c2c1 | 10.1016/j.ejmech.2020.112090 | |||
CHEMBL4793947 | 189813 | 0 | None | 2 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 327 | 6 | 1 | 5 | 2.9 | COc1ccc2[nH]cc(CCc3nn(CC4CCC4)c(=O)o3)c2c1 | 10.1016/j.ejmech.2020.112090 | |||
46885229 | 14478 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 375 | 9 | 1 | 3 | 4.6 | COc1ccc(OCc2ccccc2)c(CCCNC(=O)c2ccccc2)c1 | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL1088826 | 14478 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 375 | 9 | 1 | 3 | 4.6 | COc1ccc(OCc2ccccc2)c(CCCNC(=O)c2ccccc2)c1 | 10.1016/j.bmcl.2010.02.084 | |||
16743464 | 99101 | 0 | None | 11 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 310 | 3 | 1 | 2 | 3.9 | CC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1 | 10.1016/j.ejmech.2007.01.005 | |||
CHEMBL243002 | 99101 | 0 | None | 11 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 310 | 3 | 1 | 2 | 3.9 | CC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1 | 10.1016/j.ejmech.2007.01.005 | |||
44412141 | 83518 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 312 | 4 | 2 | 3 | 3.2 | Cn1cc(C2(CNC(=O)C3CCC3)CCC2)c2cc(O)ccc21 | 10.1021/jm0512544 | |||
CHEMBL206686 | 83518 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 312 | 4 | 2 | 3 | 3.2 | Cn1cc(C2(CNC(=O)C3CCC3)CCC2)c2cc(O)ccc21 | 10.1021/jm0512544 | |||
49865266 | 22647 | 2 | None | 1 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 225 | 5 | 1 | 3 | 1.9 | COc1ccc(SCCNC(C)=O)cc1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223126 | 22647 | 2 | None | 1 | 2 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 225 | 5 | 1 | 3 | 1.9 | COc1ccc(SCCNC(C)=O)cc1 | 10.1016/j.bmc.2010.06.100 | |||
127025782 | 144509 | 0 | None | 6 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 297 | 4 | 1 | 3 | 3.9 | COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL3759054 | 144509 | 0 | None | 6 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 297 | 4 | 1 | 3 | 3.9 | COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1 | 10.1016/j.ejmech.2015.12.047 | |||
25210134 | 196403 | 0 | None | 4 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 315 | 6 | 2 | 3 | 2.5 | COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
CHEMBL514904 | 196403 | 0 | None | 4 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 315 | 6 | 2 | 3 | 2.5 | COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
53231367 | 69179 | 0 | None | 117 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 425 | 8 | 1 | 3 | 6.0 | O=C(CCCCl)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | |||
CHEMBL1779808 | 69179 | 0 | None | 117 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 425 | 8 | 1 | 3 | 6.0 | O=C(CCCCl)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | |||
11045144 | 215061 | 0 | None | 1 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 310 | 4 | 2 | 2 | 3.0 | CCC(=O)NCc1[nH]c2cc(OC)ccc2c1Br | 10.1021/jm001125h | |||
CHEMBL98956 | 215061 | 0 | None | 1 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 310 | 4 | 2 | 2 | 3.0 | CCC(=O)NCc1[nH]c2cc(OC)ccc2c1Br | 10.1021/jm001125h | |||
56662799 | 71230 | 0 | None | 1 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 526 | 15 | 2 | 6 | 2.9 | COc1cccc(N(CCNC(C)=O)C(=O)CCCCC(=O)N(CCNC(C)=O)c2cccc(OC)c2)c1 | 10.1016/j.bmc.2011.06.063 | |||
CHEMBL1813327 | 71230 | 0 | None | 1 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 526 | 15 | 2 | 6 | 2.9 | COc1cccc(N(CCNC(C)=O)C(=O)CCCCC(=O)N(CCNC(C)=O)c2cccc(OC)c2)c1 | 10.1016/j.bmc.2011.06.063 | |||
9888609 | 15664 | 0 | None | -46 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 424 | 7 | 2 | 2 | 5.0 | CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12 | 10.1039/C5MD00190K | |||
CHEMBL1097525 | 15664 | 0 | None | -46 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 424 | 7 | 2 | 2 | 5.0 | CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12 | 10.1039/C5MD00190K | |||
9888609 | 15664 | 0 | None | -46 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 424 | 7 | 2 | 2 | 5.0 | CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12 | 10.1021/jm401343c | |||
CHEMBL1097525 | 15664 | 0 | None | -46 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 424 | 7 | 2 | 2 | 5.0 | CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12 | 10.1021/jm401343c | |||
25210134 | 196403 | 0 | None | 4 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 315 | 6 | 2 | 3 | 2.5 | COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
CHEMBL514904 | 196403 | 0 | None | 4 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 315 | 6 | 2 | 3 | 2.5 | COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
162668689 | 189537 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 285 | 5 | 1 | 4 | 2.2 | COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2020.112078 | |||
CHEMBL4790145 | 189537 | 0 | None | -1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 285 | 5 | 1 | 4 | 2.2 | COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2020.112078 | |||
44264857 | 211888 | 2 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 286 | 5 | 2 | 3 | 3.6 | CCNC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7772 | 211888 | 2 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 286 | 5 | 2 | 3 | 3.6 | CCNC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
137646628 | 164357 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 275 | 4 | 2 | 3 | 1.9 | CNC(=S)NCCc1cccc2ncc(OC)cc12 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4080608 | 164357 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 275 | 4 | 2 | 3 | 1.9 | CNC(=S)NCCc1cccc2ncc(OC)cc12 | 10.1016/j.ejmech.2016.12.013 | |||
11602301 | 83476 | 0 | None | 1 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 326 | 5 | 1 | 3 | 3.5 | COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCCC1)cn2C | 10.1021/jm0512544 | |||
CHEMBL206471 | 83476 | 0 | None | 1 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 326 | 5 | 1 | 3 | 3.5 | COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCCC1)cn2C | 10.1021/jm0512544 | |||
44349258 | 23689 | 1 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 261 | 5 | 2 | 3 | 2.4 | CCNC(=O)NCCCc1cccc2nc(C)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL125226 | 23689 | 1 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 261 | 5 | 2 | 3 | 2.4 | CCNC(=O)NCCCc1cccc2nc(C)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
137660180 | 165901 | 0 | None | 4 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 270 | 5 | 1 | 3 | 2.3 | COc1cnc2cccc(CCNC(=O)C3CC3)c2c1 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4097817 | 165901 | 0 | None | 4 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 270 | 5 | 1 | 3 | 2.3 | COc1cnc2cccc(CCNC(=O)C3CC3)c2c1 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL3109560 | 217867 | 0 | None | 2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | None | None | None | COc1ccc(/C=C/C2=[N+]3C(=Cc4c(CCNC(C)=O)c5cc(OC)ccc5n4[B-]3(F)F)C=C2)cc1 | 10.1021/ml4004155 | |||||
46885283 | 15027 | 0 | None | 48 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 237 | 6 | 1 | 3 | 1.8 | COc1ccc(OC)c(CCCNC(C)=O)c1 | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL1092400 | 15027 | 0 | None | 48 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 237 | 6 | 1 | 3 | 1.8 | COc1ccc(OC)c(CCCNC(C)=O)c1 | 10.1016/j.bmcl.2010.02.084 | |||
25210000 | 196273 | 0 | None | 11 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 408 | 7 | 2 | 5 | 3.3 | COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
CHEMBL513933 | 196273 | 0 | None | 11 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 408 | 7 | 2 | 5 | 3.3 | COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
49865323 | 22672 | 0 | None | 2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 267 | 7 | 1 | 3 | 3.1 | CCCC(=O)NC[C@@H](C)Sc1cccc(OC)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223197 | 22672 | 0 | None | 2 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 267 | 7 | 1 | 3 | 3.1 | CCCC(=O)NC[C@@H](C)Sc1cccc(OC)c1 | 10.1016/j.bmc.2010.06.100 | |||
25210000 | 196273 | 0 | None | 11 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 408 | 7 | 2 | 5 | 3.3 | COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
CHEMBL513933 | 196273 | 0 | None | 11 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 408 | 7 | 2 | 5 | 3.3 | COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
9925874 | 169009 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 285 | 6 | 1 | 3 | 4.2 | CCCC(=O)Nc1cccc(Oc2cccc(OC)c2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL416328 | 169009 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 285 | 6 | 1 | 3 | 4.2 | CCCC(=O)Nc1cccc(Oc2cccc(OC)c2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
145975938 | 170678 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 519 | 14 | 3 | 6 | 5.4 | CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(O)c3)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
CHEMBL4207166 | 170678 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 519 | 14 | 3 | 6 | 5.4 | CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(O)c3)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
162674710 | 190113 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 270 | 3 | 1 | 4 | 2.4 | COc1ccc2c(c1)C(/C=C/c1n[nH]c(=O)o1)=CCC2 | 10.1016/j.ejmech.2020.112090 | |||
CHEMBL4797429 | 190113 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 270 | 3 | 1 | 4 | 2.4 | COc1ccc2c(c1)C(/C=C/c1n[nH]c(=O)o1)=CCC2 | 10.1016/j.ejmech.2020.112090 | |||
46935149 | 22623 | 2 | None | -2 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 239 | 5 | 1 | 3 | 2.3 | COc1cccc(SC(C)CNC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223051 | 22623 | 2 | None | -2 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 239 | 5 | 1 | 3 | 2.3 | COc1cccc(SC(C)CNC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
49865378 | 22707 | 0 | None | 1 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 239 | 5 | 1 | 3 | 2.3 | COc1cccc(SC[C@H](C)NC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223281 | 22707 | 0 | None | 1 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 239 | 5 | 1 | 3 | 2.3 | COc1cccc(SC[C@H](C)NC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
22718661 | 23611 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 274 | 7 | 1 | 3 | 3.2 | CCCc1nc2cccc(CCCNC(=O)CC)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL124783 | 23611 | 0 | None | 1 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 274 | 7 | 1 | 3 | 3.2 | CCCc1nc2cccc(CCCNC(=O)CC)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
24749950 | 10688 | 8 | None | 588 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 284 | 6 | 1 | 3 | 3.0 | COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C | 10.1021/jm700957j | |||
7923 | 10688 | 8 | None | 588 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 284 | 6 | 1 | 3 | 3.0 | COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C | 10.1021/jm700957j | |||
CHEMBL394676 | 10688 | 8 | None | 588 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 284 | 6 | 1 | 3 | 3.0 | COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C | 10.1021/jm700957j | |||
46885288 | 15101 | 0 | None | 95 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 343 | 9 | 1 | 4 | 3.4 | COc1ccc(COc2ccc(OC)cc2CCCNC(C)=O)cc1 | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL1092839 | 15101 | 0 | None | 95 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 343 | 9 | 1 | 4 | 3.4 | COc1ccc(COc2ccc(OC)cc2CCCNC(C)=O)cc1 | 10.1016/j.bmcl.2010.02.084 | |||
10903368 | 214883 | 0 | None | 4 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 3.7 | CCC(=O)NCc1cc2ccc(OC)cc2n1Cc1ccccc1 | 10.1021/jm001125h | |||
CHEMBL97885 | 214883 | 0 | None | 4 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 3.7 | CCC(=O)NCc1cc2ccc(OC)cc2n1Cc1ccccc1 | 10.1021/jm001125h | |||
164946945 | 197008 | 1 | None | 1 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 427 | 9 | 1 | 7 | 3.3 | COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | |||
CHEMBL5174929 | 197008 | 1 | None | 1 | 2 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 427 | 9 | 1 | 7 | 3.3 | COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | |||
11529521 | 83534 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 298 | 5 | 2 | 2 | 3.1 | COc1ccc2[nH]cc(C3(CNC(=O)C4CC4)CCC3)c2c1 | 10.1021/jm0512544 | |||
CHEMBL206790 | 83534 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 298 | 5 | 2 | 2 | 3.1 | COc1ccc2[nH]cc(C3(CNC(=O)C4CC4)CCC3)c2c1 | 10.1021/jm0512544 | |||
162645859 | 186486 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 315 | 3 | 1 | 5 | 1.5 | CCNC(=O)N1CCN(c2ncnc3ccc(OC)cc23)CC1 | 10.1016/j.ejmech.2020.112078 | |||
CHEMBL4743884 | 186486 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 315 | 3 | 1 | 5 | 1.5 | CCNC(=O)N1CCN(c2ncnc3ccc(OC)cc23)CC1 | 10.1016/j.ejmech.2020.112078 | |||
10657206 | 126467 | 2 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 2.2 | CCC(=O)NCc1cc2c(OC)cccc2[nH]1 | 10.1021/jm001125h | |||
CHEMBL34728 | 126467 | 2 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 2.2 | CCC(=O)NCc1cc2c(OC)cccc2[nH]1 | 10.1021/jm001125h | |||
11326232 | 134202 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 372 | 6 | 1 | 5 | 2.9 | CCC(=O)NCc1cc2c(OC)cccc2n1S(=O)(=O)c1ccccc1 | 10.1021/jm048956y | |||
CHEMBL366004 | 134202 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 372 | 6 | 1 | 5 | 2.9 | CCC(=O)NCc1cc2c(OC)cccc2n1S(=O)(=O)c1ccccc1 | 10.1021/jm048956y | |||
10091075 | 24053 | 0 | None | -8 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 378 | 11 | 1 | 3 | 5.2 | CCCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL125705 | 24053 | 0 | None | -8 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 378 | 11 | 1 | 3 | 5.2 | CCCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
22718654 | 120109 | 0 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 288 | 7 | 1 | 3 | 3.5 | CCCc1nc2cccc(CCCNC(=O)C(C)C)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL331636 | 120109 | 0 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 288 | 7 | 1 | 3 | 3.5 | CCCc1nc2cccc(CCCNC(=O)C(C)C)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
85880795 | 117645 | 0 | None | -12 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 319 | 9 | 1 | 3 | 4.0 | CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2 | 10.1021/jm401343c | |||
CHEMBL3260984 | 117645 | 0 | None | -12 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 319 | 9 | 1 | 3 | 4.0 | CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2 | 10.1021/jm401343c | |||
11065731 | 108658 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 277 | 5 | 2 | 4 | 1.8 | COc1cc([N+](=O)[O-])c2[nH]cc(CCNC(C)=O)c2c1 | 10.1021/jm011053+ | |||
CHEMBL300729 | 108658 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 277 | 5 | 2 | 4 | 1.8 | COc1cc([N+](=O)[O-])c2[nH]cc(CCNC(C)=O)c2c1 | 10.1021/jm011053+ | |||
145976375 | 170576 | 0 | None | -10 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 525 | 15 | 2 | 6 | 5.7 | CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
CHEMBL4206000 | 170576 | 0 | None | -10 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 525 | 15 | 2 | 6 | 5.7 | CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
145990308 | 173811 | 0 | None | 13 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 328 | 5 | 2 | 2 | 3.8 | CCCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4288690 | 173811 | 0 | None | 13 | 3 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 328 | 5 | 2 | 2 | 3.8 | CCCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
145986700 | 173998 | 0 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 328 | 4 | 2 | 2 | 3.5 | CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4292109 | 173998 | 0 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 328 | 4 | 2 | 2 | 3.5 | CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
139451767 | 191783 | 0 | None | -2 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 263 | 5 | 1 | 5 | 1.2 | COc1ccc2nc(OC)n(CCNC(C)=O)c2c1 | 10.1021/acs.jmedchem.0c00627 | |||
CHEMBL4854625 | 191783 | 0 | None | -2 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 263 | 5 | 1 | 5 | 1.2 | COc1ccc2nc(OC)n(CCNC(C)=O)c2c1 | 10.1021/acs.jmedchem.0c00627 | |||
11776674 | 123427 | 1 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 246 | 4 | 1 | 3 | 1.9 | COc1ccc2c(c1)c(CCNC(C)=O)cn2C | 10.1021/jm011053+ | |||
CHEMBL33700 | 123427 | 1 | None | 1 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 246 | 4 | 1 | 3 | 1.9 | COc1ccc2c(c1)c(CCNC(C)=O)cn2C | 10.1021/jm011053+ | |||
139451799 | 192618 | 0 | None | -3 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 279 | 5 | 1 | 5 | 1.9 | COc1ccc2nc(SC)n(CCNC(C)=O)c2c1 | 10.1021/acs.jmedchem.0c00627 | |||
CHEMBL4867553 | 192618 | 0 | None | -3 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 279 | 5 | 1 | 5 | 1.9 | COc1ccc2nc(SC)n(CCNC(C)=O)c2c1 | 10.1021/acs.jmedchem.0c00627 | |||
10938056 | 113835 | 0 | None | 2 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 393 | 11 | 1 | 3 | 5.7 | CCCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
CHEMBL315653 | 113835 | 0 | None | 2 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 393 | 11 | 1 | 3 | 5.7 | CCCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
11637615 | 84022 | 0 | None | 2 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 272 | 4 | 2 | 2 | 2.7 | COc1ccc2[nH]cc(C3(CNC(C)=O)CCC3)c2c1 | 10.1021/jm0512544 | |||
CHEMBL207960 | 84022 | 0 | None | 2 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 272 | 4 | 2 | 2 | 2.7 | COc1ccc2[nH]cc(C3(CNC(C)=O)CCC3)c2c1 | 10.1021/jm0512544 | |||
71508234 | 7492 | 0 | None | 38 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 341 | 9 | 1 | 3 | 3.8 | CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC | 10.1016/j.bmc.2012.10.060 | |||
7924 | 7492 | 0 | None | 38 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 341 | 9 | 1 | 3 | 3.8 | CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC | 10.1016/j.bmc.2012.10.060 | |||
CHEMBL2326202 | 7492 | 0 | None | 38 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 341 | 9 | 1 | 3 | 3.8 | CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC | 10.1016/j.bmc.2012.10.060 | |||
10427851 | 188612 | 0 | None | 407 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 3.7 | COc1ccc2cc(-c3cccc(CN)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL477834 | 188612 | 0 | None | 407 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 348 | 6 | 2 | 3 | 3.7 | COc1ccc2cc(-c3cccc(CN)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
122193492 | 130720 | 0 | None | 3 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 261 | 4 | 1 | 4 | 1.5 | COc1ccc2oc(=O)cc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2015.09.003 | |||
CHEMBL3628489 | 130720 | 0 | None | 3 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 261 | 4 | 1 | 4 | 1.5 | COc1ccc2oc(=O)cc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2015.09.003 | |||
189748 | 23588 | 9 | None | 60 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 262 | 5 | 2 | 3 | 1.9 | COc1cc2[nH]cc(CCNC(C)=O)c2cc1OC | 10.1021/jm401343c | |||
CHEMBL124699 | 23588 | 9 | None | 60 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 262 | 5 | 2 | 3 | 1.9 | COc1cc2[nH]cc(CCNC(C)=O)c2cc1OC | 10.1021/jm401343c | |||
11088627 | 214324 | 0 | None | 8 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 324 | 6 | 1 | 4 | 3.1 | COc1ccc2oc(Cc3cccnc3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
CHEMBL94745 | 214324 | 0 | None | 8 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 324 | 6 | 1 | 4 | 3.1 | COc1ccc2oc(Cc3cccnc3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
44349108 | 23636 | 0 | None | 2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 246 | 6 | 1 | 3 | 2.7 | CCCC(=O)NCCCc1cccc2ncoc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL124914 | 23636 | 0 | None | 2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 246 | 6 | 1 | 3 | 2.7 | CCCC(=O)NCCCc1cccc2ncoc12 | 10.1016/j.bmcl.2004.04.082 | |||
10711649 | 214563 | 0 | None | 19 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 332 | 5 | 1 | 2 | 4.3 | CCCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2 | 10.1021/jm980684+ | |||
CHEMBL9605 | 214563 | 0 | None | 19 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 332 | 5 | 1 | 2 | 4.3 | CCCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2 | 10.1021/jm980684+ | |||
90666306 | 116160 | 0 | None | 1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 377 | 7 | 2 | 3 | 3.8 | CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12 | 10.1039/C1MD00149C | |||
CHEMBL3219327 | 116160 | 0 | None | 1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 377 | 7 | 2 | 3 | 3.8 | CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12 | 10.1039/C1MD00149C | |||
24750194 | 96723 | 0 | None | 87 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 324 | 7 | 1 | 3 | 3.8 | COc1cccc(N(CCNC(=O)C2CCC2)c2ccccc2)c1 | 10.1021/jm700957j | |||
CHEMBL238049 | 96723 | 0 | None | 87 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 324 | 7 | 1 | 3 | 3.8 | COc1cccc(N(CCNC(=O)C2CCC2)c2ccccc2)c1 | 10.1021/jm700957j | |||
49865319 | 22668 | 0 | None | 1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 251 | 7 | 1 | 3 | 2.4 | CCCC(=O)NCC(C)Oc1cccc(OC)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223193 | 22668 | 0 | None | 1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 251 | 7 | 1 | 3 | 2.4 | CCCC(=O)NCC(C)Oc1cccc(OC)c1 | 10.1016/j.bmc.2010.06.100 | |||
137644121 | 164928 | 0 | None | 7 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 291 | 4 | 1 | 1 | 4.0 | CCC(=O)NCC1=C(c2ccccc2)c2ccccc2CC1 | 10.1021/acs.jmedchem.8b00359 | |||
CHEMBL4087265 | 164928 | 0 | None | 7 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 291 | 4 | 1 | 1 | 4.0 | CCC(=O)NCC1=C(c2ccccc2)c2ccccc2CC1 | 10.1021/acs.jmedchem.8b00359 | |||
86273227 | 128095 | 0 | None | 3 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 242 | 4 | 2 | 2 | 1.5 | C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12 | 10.1021/acs.jmedchem.5b00245 | |||
CHEMBL3580907 | 128095 | 0 | None | 3 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 242 | 4 | 2 | 2 | 1.5 | C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12 | 10.1021/acs.jmedchem.5b00245 | |||
10800029 | 123488 | 0 | None | 1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 239 | 3 | 1 | 1 | 3.0 | CC(=O)NCCC1Cc2cccc3cccc1c23 | 10.1021/jm000922c | |||
CHEMBL337295 | 123488 | 0 | None | 1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 239 | 3 | 1 | 1 | 3.0 | CC(=O)NCCC1Cc2cccc3cccc1c23 | 10.1021/jm000922c | |||
24750190 | 96660 | 1 | None | 32 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 254 | 5 | 1 | 2 | 3.0 | CC(=O)NCCN(c1ccccc1)c1ccccc1 | 10.1021/jm700957j | |||
CHEMBL237840 | 96660 | 1 | None | 32 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 254 | 5 | 1 | 2 | 3.0 | CC(=O)NCCN(c1ccccc1)c1ccccc1 | 10.1021/jm700957j | |||
139451780 | 192723 | 0 | None | -5 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 303 | 7 | 1 | 5 | 2.0 | CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1 | 10.1021/acs.jmedchem.0c00627 | |||
CHEMBL4869463 | 192723 | 0 | None | -5 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 303 | 7 | 1 | 5 | 2.0 | CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1 | 10.1021/acs.jmedchem.0c00627 | |||
44389845 | 71606 | 0 | None | -15 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 377 | 10 | 1 | 2 | 4.9 | O=C(NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1 | 10.1016/j.bmcl.2005.01.015 | |||
CHEMBL181974 | 71606 | 0 | None | -15 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 377 | 10 | 1 | 2 | 4.9 | O=C(NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1 | 10.1016/j.bmcl.2005.01.015 | |||
44389813 | 138152 | 0 | None | -15 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 379 | 11 | 1 | 2 | 5.3 | CCCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
CHEMBL368886 | 138152 | 0 | None | -15 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 379 | 11 | 1 | 2 | 5.3 | CCCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
54582195 | 67536 | 0 | None | 3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 329 | 5 | 1 | 5 | 1.9 | COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | |||
CHEMBL1760955 | 67536 | 0 | None | 3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 329 | 5 | 1 | 5 | 1.9 | COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | |||
25209999 | 182297 | 0 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 441 | 6 | 2 | 3 | 4.2 | COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
CHEMBL457807 | 182297 | 0 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 441 | 6 | 2 | 3 | 4.2 | COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
11173131 | 130876 | 0 | None | 7 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 265 | 2 | 1 | 1 | 3.1 | CC(=O)NCC1Cc2ccccc2Cc2ccccc21 | 10.1021/jm040768k | |||
CHEMBL363321 | 130876 | 0 | None | 7 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 265 | 2 | 1 | 1 | 3.1 | CC(=O)NCC1Cc2ccccc2Cc2ccccc21 | 10.1021/jm040768k | |||
25209999 | 182297 | 0 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 441 | 6 | 2 | 3 | 4.2 | COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
CHEMBL457807 | 182297 | 0 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 441 | 6 | 2 | 3 | 4.2 | COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1 | 10.1021/jm800974d | |||
162667374 | 189334 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 357 | 10 | 1 | 5 | 4.1 | CCCCCCCn1nc(CCc2c[nH]c3ccc(OC)cc23)oc1=O | 10.1016/j.ejmech.2020.112090 | |||
CHEMBL4787595 | 189334 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 357 | 10 | 1 | 5 | 4.1 | CCCCCCCn1nc(CCc2c[nH]c3ccc(OC)cc23)oc1=O | 10.1016/j.ejmech.2020.112090 | |||
44429452 | 94140 | 0 | None | 4 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 308 | 5 | 2 | 2 | 3.5 | COc1cc(-c2ccccc2)c2[nH]cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL233311 | 94140 | 0 | None | 4 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 308 | 5 | 2 | 2 | 3.5 | COc1cc(-c2ccccc2)c2[nH]cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.04.013 | |||
49865375 | 22704 | 0 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 223 | 5 | 1 | 3 | 1.6 | COc1cccc(OC[C@H](C)NC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223278 | 22704 | 0 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 223 | 5 | 1 | 3 | 1.6 | COc1cccc(OC[C@H](C)NC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
10737123 | 104155 | 0 | None | -1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 358 | 4 | 1 | 2 | 4.7 | O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CCC1 | 10.1021/jm980684+ | |||
CHEMBL269670 | 104155 | 0 | None | -1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 358 | 4 | 1 | 2 | 4.7 | O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CCC1 | 10.1021/jm980684+ | |||
56662798 | 71229 | 0 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 554 | 21 | 2 | 6 | 5.4 | COc1cccc(N(CCCCCCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1 | 10.1016/j.bmc.2011.06.063 | |||
CHEMBL1813326 | 71229 | 0 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 554 | 21 | 2 | 6 | 5.4 | COc1cccc(N(CCCCCCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1 | 10.1016/j.bmc.2011.06.063 | |||
11794657 | 215100 | 0 | None | 23 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 388 | 5 | 1 | 3 | 4.7 | COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCCc2ccccc2-1 | 10.1021/jm980684+ | |||
CHEMBL9917 | 215100 | 0 | None | 23 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 388 | 5 | 1 | 3 | 4.7 | COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCCc2ccccc2-1 | 10.1021/jm980684+ | |||
CHEMBL3109561 | 217868 | 0 | None | -6 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | None | None | None | COc1ccc(C2=[N+]3C(=Cc4c(CCNC(C)=O)c5cc(OC)ccc5n4[B-]3(F)F)C=C2)cc1 | 10.1021/ml4004155 | |||||
11680808 | 83854 | 0 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 286 | 5 | 2 | 2 | 3.1 | CCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1 | 10.1021/jm0512544 | |||
CHEMBL207420 | 83854 | 0 | None | 2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 286 | 5 | 2 | 2 | 3.1 | CCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1 | 10.1021/jm0512544 | |||
145978811 | 170639 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 531 | 16 | 2 | 5 | 6.4 | CC(=O)NCCN(C)c1cccc(OCCCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
CHEMBL4206642 | 170639 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 531 | 16 | 2 | 5 | 6.4 | CC(=O)NCCN(C)c1cccc(OCCCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
162668486 | 189353 | 0 | None | 2 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 377 | 8 | 1 | 5 | 3.7 | COc1ccc2[nH]cc(CCc3nn(CCCc4ccccc4)c(=O)o3)c2c1 | 10.1016/j.ejmech.2020.112090 | |||
CHEMBL4787877 | 189353 | 0 | None | 2 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 377 | 8 | 1 | 5 | 3.7 | COc1ccc2[nH]cc(CCc3nn(CCCc4ccccc4)c(=O)o3)c2c1 | 10.1016/j.ejmech.2020.112090 | |||
10595585 | 105322 | 0 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 374 | 5 | 1 | 3 | 4.3 | COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCc2ccccc2-1 | 10.1021/jm980684+ | |||
CHEMBL276490 | 105322 | 0 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 374 | 5 | 1 | 3 | 4.3 | COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCc2ccccc2-1 | 10.1021/jm980684+ | |||
162646341 | 186279 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 312 | 3 | 0 | 5 | 1.7 | COc1ccc2ncnc(N3CCN(C(=O)C4CC4)CC3)c2c1 | 10.1016/j.ejmech.2020.112078 | |||
CHEMBL4741114 | 186279 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 312 | 3 | 0 | 5 | 1.7 | COc1ccc2ncnc(N3CCN(C(=O)C4CC4)CC3)c2c1 | 10.1016/j.ejmech.2020.112078 | |||
9817692 | 212440 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 297 | 6 | 1 | 3 | 3.7 | CCCC(=O)Nc1ccc(C(=O)c2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL8200 | 212440 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 297 | 6 | 1 | 3 | 3.7 | CCCC(=O)Nc1ccc(C(=O)c2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
44394394 | 129488 | 0 | None | -2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 387 | 9 | 1 | 2 | 5.6 | O=C(NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12)C1CC1 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL360428 | 129488 | 0 | None | -2 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 387 | 9 | 1 | 2 | 5.6 | O=C(NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12)C1CC1 | 10.1016/j.bmcl.2004.07.055 | |||
11515177 | 147838 | 0 | None | 5 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 314 | 5 | 1 | 3 | 3.4 | COc1ccc2c(c1)c(C(C)(C)CNC(=O)C1CCC1)cn2C | 10.1021/jm0512544 | |||
CHEMBL382439 | 147838 | 0 | None | 5 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 314 | 5 | 1 | 3 | 3.4 | COc1ccc2c(c1)c(C(C)(C)CNC(=O)C1CCC1)cn2C | 10.1021/jm0512544 | |||
145963877 | 171035 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 503 | 14 | 2 | 5 | 5.7 | CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
CHEMBL4211530 | 171035 | 0 | None | -1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 503 | 14 | 2 | 5 | 5.7 | CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
44587356 | 200163 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 423 | 8 | 3 | 5 | 2.8 | COc1ccc2c(c1)CC(CO)N2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O | 10.1016/j.bmc.2008.07.012 | |||
CHEMBL525374 | 200163 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 423 | 8 | 3 | 5 | 2.8 | COc1ccc2c(c1)CC(CO)N2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O | 10.1016/j.bmc.2008.07.012 | |||
90666308 | 116162 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 389 | 7 | 2 | 3 | 3.8 | COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CC3)c2c1 | 10.1039/C1MD00149C | |||
CHEMBL3219329 | 116162 | 0 | None | 1 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 389 | 7 | 2 | 3 | 3.8 | COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CC3)c2c1 | 10.1039/C1MD00149C | |||
10520058 | 104914 | 0 | None | 8 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 324 | 3 | 1 | 2 | 4.0 | CC(=O)NCCc1c2n(c3ccc(Cl)cc13)Cc1ccccc1-2 | 10.1021/jm980684+ | |||
CHEMBL273624 | 104914 | 0 | None | 8 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 324 | 3 | 1 | 2 | 4.0 | CC(=O)NCCc1c2n(c3ccc(Cl)cc13)Cc1ccccc1-2 | 10.1021/jm980684+ | |||
145968467 | 171568 | 0 | None | -5 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 400 | 13 | 2 | 5 | 4.0 | CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(O)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
CHEMBL4218247 | 171568 | 0 | None | -5 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 400 | 13 | 2 | 5 | 4.0 | CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(O)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
13250272 | 22646 | 17 | None | 11 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 195 | 4 | 1 | 2 | 1.9 | CC(=O)NCCSc1ccccc1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223125 | 22646 | 17 | None | 11 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 195 | 4 | 1 | 2 | 1.9 | CC(=O)NCCSc1ccccc1 | 10.1016/j.bmc.2010.06.100 | |||
10950593 | 118298 | 0 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 459 | 6 | 1 | 3 | 5.7 | COc1ccc2oc(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
CHEMBL327864 | 118298 | 0 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 459 | 6 | 1 | 3 | 5.7 | COc1ccc2oc(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
49865373 | 22702 | 2 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 223 | 5 | 1 | 3 | 1.6 | COc1cccc(OCC(C)NC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223276 | 22702 | 2 | None | 1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 223 | 5 | 1 | 3 | 1.6 | COc1cccc(OCC(C)NC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
9860296 | 35990 | 0 | None | -8 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 272 | 3 | 1 | 3 | 1.7 | O=C(N[C@@H]1CCN(c2cccc3c2CCO3)C1)C1CC1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL138228 | 35990 | 0 | None | -8 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 272 | 3 | 1 | 3 | 1.7 | O=C(N[C@@H]1CCN(c2cccc3c2CCO3)C1)C1CC1 | 10.1016/j.bmcl.2003.09.030 | |||
22718579 | 23294 | 0 | None | 3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 260 | 5 | 1 | 3 | 3.0 | CC(=O)NCCCc1cccc2nc(C(C)C)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL123690 | 23294 | 0 | None | 3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 260 | 5 | 1 | 3 | 3.0 | CC(=O)NCCCc1cccc2nc(C(C)C)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
22718521 | 23425 | 0 | None | 5 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 260 | 6 | 1 | 3 | 2.8 | CCCc1nc2cccc(CCCNC(C)=O)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL124216 | 23425 | 0 | None | 5 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 260 | 6 | 1 | 3 | 2.8 | CCCc1nc2cccc(CCCNC(C)=O)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
21581653 | 144821 | 0 | None | -3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 233 | 4 | 2 | 3 | 1.3 | COc1cc2c(CCNC(C)=O)c[nH]c2cn1 | 10.1016/j.ejmech.2016.01.008 | |||
CHEMBL3765249 | 144821 | 0 | None | -3 | 2 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 233 | 4 | 2 | 3 | 1.3 | COc1cc2c(CCNC(C)=O)c[nH]c2cn1 | 10.1016/j.ejmech.2016.01.008 | |||
10638747 | 215146 | 0 | None | 11 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 310 | 4 | 2 | 2 | 2.6 | COc1ccc2c(Br)c(CCNC(C)=O)[nH]c2c1 | 10.1021/jm001125h | |||
CHEMBL99512 | 215146 | 0 | None | 11 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 310 | 4 | 2 | 2 | 2.6 | COc1ccc2c(Br)c(CCNC(C)=O)[nH]c2c1 | 10.1021/jm001125h | |||
1362 | 10210 | 22 | None | -39 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 498 | 12 | 2 | 4 | 5.2 | CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1039/C5MD00190K | |||
9870523 | 10210 | 22 | None | -39 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 498 | 12 | 2 | 4 | 5.2 | CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1039/C5MD00190K | |||
CHEMBL429392 | 10210 | 22 | None | -39 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 498 | 12 | 2 | 4 | 5.2 | CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1039/C5MD00190K | |||
10736247 | 215142 | 0 | None | 5 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 344 | 4 | 1 | 2 | 4.3 | O=C(NCCc1c2n(c3ccccc13)CCc1ccccc1-2)C1CCC1 | 10.1021/jm980684+ | |||
CHEMBL9950 | 215142 | 0 | None | 5 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 344 | 4 | 1 | 2 | 4.3 | O=C(NCCc1c2n(c3ccccc13)CCc1ccccc1-2)C1CCC1 | 10.1021/jm980684+ | |||
44349329 | 25320 | 1 | None | 13 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 289 | 7 | 2 | 3 | 3.0 | CCCc1nc2cccc(CCCNC(=O)NCC)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL127565 | 25320 | 1 | None | 13 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 289 | 7 | 2 | 3 | 3.0 | CCCc1nc2cccc(CCCNC(=O)NCC)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
44587357 | 194929 | 0 | None | -2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 393 | 7 | 3 | 4 | 2.8 | COc1ccc2[nH]c(CN3c4ccccc4CC3CO)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.07.012 | |||
CHEMBL498494 | 194929 | 0 | None | -2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 393 | 7 | 3 | 4 | 2.8 | COc1ccc2[nH]c(CN3c4ccccc4CC3CO)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.07.012 | |||
10709646 | 214612 | 0 | None | 10 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 304 | 3 | 1 | 2 | 3.5 | CC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2 | 10.1021/jm980684+ | |||
CHEMBL9634 | 214612 | 0 | None | 10 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 304 | 3 | 1 | 2 | 3.5 | CC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2 | 10.1021/jm980684+ | |||
56671858 | 71228 | 0 | None | 20 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 498 | 17 | 2 | 6 | 3.8 | COc1cccc(N(CCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1 | 10.1016/j.bmc.2011.06.063 | |||
CHEMBL1813325 | 71228 | 0 | None | 20 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 498 | 17 | 2 | 6 | 3.8 | COc1cccc(N(CCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1 | 10.1016/j.bmc.2011.06.063 | |||
10948786 | 214579 | 0 | None | 18 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 375 | 7 | 1 | 4 | 4.6 | COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)c3ccco3)c2c1 | 10.1021/jm0005252 | |||
CHEMBL96173 | 214579 | 0 | None | 18 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 375 | 7 | 1 | 4 | 4.6 | COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)c3ccco3)c2c1 | 10.1021/jm0005252 | |||
11624018 | 147666 | 0 | None | -5 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 326 | 5 | 1 | 3 | 3.5 | COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCC1)cn2C | 10.1021/jm0512544 | |||
CHEMBL382050 | 147666 | 0 | None | -5 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 326 | 5 | 1 | 3 | 3.5 | COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCC1)cn2C | 10.1021/jm0512544 | |||
44349305 | 177915 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 320 | 6 | 1 | 3 | 4.0 | O=C(NCCCc1cccc2nc(-c3ccccc3)oc12)C1CC1 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL445840 | 177915 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 320 | 6 | 1 | 3 | 4.0 | O=C(NCCCc1cccc2nc(-c3ccccc3)oc12)C1CC1 | 10.1016/j.bmcl.2004.04.082 | |||
11393103 | 132582 | 0 | None | 1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 322 | 5 | 1 | 3 | 3.8 | CCC(=O)NCCN1c2ccccc2C=Cc2ccc(OC)cc21 | 10.1021/jm040768k | |||
CHEMBL364806 | 132582 | 0 | None | 1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 322 | 5 | 1 | 3 | 3.8 | CCC(=O)NCCN1c2ccccc2C=Cc2ccc(OC)cc21 | 10.1021/jm040768k | |||
118712360 | 120928 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 330 | 4 | 0 | 4 | 2.6 | CCN(CC)C(=O)CN1CCCC2Cc3cc4c(cc3C21)OCO4 | 10.1016/j.ejmech.2014.09.038 | |||
CHEMBL3329377 | 120928 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 330 | 4 | 0 | 4 | 2.6 | CCN(CC)C(=O)CN1CCCC2Cc3cc4c(cc3C21)OCO4 | 10.1016/j.ejmech.2014.09.038 | |||
12436514 | 22699 | 6 | None | 3 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 193 | 4 | 1 | 2 | 1.6 | CC(=O)NC(C)COc1ccccc1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223273 | 22699 | 6 | None | 3 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 193 | 4 | 1 | 2 | 1.6 | CC(=O)NC(C)COc1ccccc1 | 10.1016/j.bmc.2010.06.100 | |||
44264983 | 212177 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 4.1 | CCCC(=O)Nc1ccc(Nc2cccc3c2CCO3)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL8004 | 212177 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 296 | 5 | 2 | 3 | 4.1 | CCCC(=O)Nc1ccc(Nc2cccc3c2CCO3)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
11623375 | 145470 | 0 | None | 2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 286 | 5 | 1 | 3 | 2.7 | CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1 | 10.1021/jm0512544 | |||
CHEMBL377871 | 145470 | 0 | None | 2 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 286 | 5 | 1 | 3 | 2.7 | CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1 | 10.1021/jm0512544 | |||
10454621 | 108657 | 4 | None | 47 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 5 | 1 | 5 | 2.4 | COc1ccc2c(c(CCNC(C)=O)c(I)n2C)c1[N+](=O)[O-] | 10.1021/jm011053+ | |||
CHEMBL300728 | 108657 | 4 | None | 47 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 417 | 5 | 1 | 5 | 2.4 | COc1ccc2c(c(CCNC(C)=O)c(I)n2C)c1[N+](=O)[O-] | 10.1021/jm011053+ | |||
44358035 | 36737 | 0 | None | 1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 260 | 3 | 1 | 3 | 1.7 | CCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL138848 | 36737 | 0 | None | 1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 260 | 3 | 1 | 3 | 1.7 | CCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
11392720 | 73825 | 0 | None | 4 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 309 | 4 | 1 | 2 | 3.5 | COc1ccc2c(c1)C(CCNC(C)=O)Cc1ccccc1C2 | 10.1021/jm040768k | |||
CHEMBL187160 | 73825 | 0 | None | 4 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 309 | 4 | 1 | 2 | 3.5 | COc1ccc2c(c1)C(CCNC(C)=O)Cc1ccccc1C2 | 10.1021/jm040768k | |||
168288029 | 198400 | 0 | None | 1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 471 | 9 | 1 | 9 | 3.4 | COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | |||
CHEMBL5195595 | 198400 | 0 | None | 1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 471 | 9 | 1 | 9 | 3.4 | COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | |||
49865265 | 22645 | 2 | None | 1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 225 | 5 | 1 | 3 | 1.9 | COc1cccc(SCCNC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223124 | 22645 | 2 | None | 1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 225 | 5 | 1 | 3 | 1.9 | COc1cccc(SCCNC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
162644334 | 188598 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 341 | 6 | 1 | 5 | 3.3 | COc1ccc2[nH]cc(CCc3nn(CC4CCCC4)c(=O)o3)c2c1 | 10.1016/j.ejmech.2020.112090 | |||
CHEMBL4778192 | 188598 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 341 | 6 | 1 | 5 | 3.3 | COc1ccc2[nH]cc(CCc3nn(CC4CCCC4)c(=O)o3)c2c1 | 10.1016/j.ejmech.2020.112090 | |||
162643514 | 188466 | 0 | None | 1 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 271 | 5 | 1 | 4 | 1.7 | COc1ccc2ncnc(CCNC(=O)C3CC3)c2c1 | 10.1016/j.ejmech.2020.112078 | |||
CHEMBL4776540 | 188466 | 0 | None | 1 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 271 | 5 | 1 | 4 | 1.7 | COc1ccc2ncnc(CCNC(=O)C3CC3)c2c1 | 10.1016/j.ejmech.2020.112078 | |||
145965883 | 170861 | 0 | None | 1 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 307 | 11 | 2 | 4 | 2.2 | CC(=O)NCCN(C)c1cccc(OCCCCCCN)c1 | 10.1021/acs.jmedchem.8b00893 | |||
CHEMBL4209446 | 170861 | 0 | None | 1 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 307 | 11 | 2 | 4 | 2.2 | CC(=O)NCCN(C)c1cccc(OCCCCCCN)c1 | 10.1021/acs.jmedchem.8b00893 | |||
122178509 | 128106 | 0 | None | 8 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 259 | 4 | 2 | 4 | 1.6 | COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
CHEMBL3580919 | 128106 | 0 | None | 8 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 259 | 4 | 2 | 4 | 1.6 | COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
137655435 | 165589 | 0 | None | 15 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 244 | 4 | 1 | 3 | 1.9 | COc1cnc2cccc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4094436 | 165589 | 0 | None | 15 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 244 | 4 | 1 | 3 | 1.9 | COc1cnc2cccc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2016.12.013 | |||
122178509 | 128106 | 0 | None | 8 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 259 | 4 | 2 | 4 | 1.6 | COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1 | 10.1016/j.ejmech.2020.112090 | |||
CHEMBL3580919 | 128106 | 0 | None | 8 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 259 | 4 | 2 | 4 | 1.6 | COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1 | 10.1016/j.ejmech.2020.112090 | |||
9796251 | 124888 | 0 | None | -1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 297 | 5 | 1 | 2 | 3.8 | CCC(=O)NCCC1CCc2c(OC)ccc3cccc1c23 | 10.1021/jm000922c | |||
CHEMBL340745 | 124888 | 0 | None | -1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 297 | 5 | 1 | 2 | 3.8 | CCC(=O)NCCC1CCc2c(OC)ccc3cccc1c23 | 10.1021/jm000922c | |||
9839199 | 28135 | 0 | None | 1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 297 | 5 | 1 | 2 | 3.8 | CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23 | 10.1021/jm000922c | |||
CHEMBL131424 | 28135 | 0 | None | 1 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 297 | 5 | 1 | 2 | 3.8 | CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23 | 10.1021/jm000922c | |||
9859913 | 212309 | 0 | None | 20 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 257 | 4 | 1 | 3 | 3.4 | COc1cccc(Oc2ccc(NC(C)=O)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL8094 | 212309 | 0 | None | 20 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 257 | 4 | 1 | 3 | 3.4 | COc1cccc(Oc2ccc(NC(C)=O)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
44264707 | 103946 | 1 | None | 19 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 256 | 4 | 2 | 3 | 3.4 | COc1cccc(Nc2ccc(NC(C)=O)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL268165 | 103946 | 1 | None | 19 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 256 | 4 | 2 | 3 | 3.4 | COc1cccc(Nc2ccc(NC(C)=O)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
127025787 | 144510 | 0 | None | 4 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 298 | 4 | 2 | 3 | 3.4 | CCNC(=O)NCc1cc2c(ccc3ccc(OC)cc32)o1 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL3759080 | 144510 | 0 | None | 4 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 298 | 4 | 2 | 3 | 3.4 | CCNC(=O)NCc1cc2c(ccc3ccc(OC)cc32)o1 | 10.1016/j.ejmech.2015.12.047 | |||
46888522 | 15417 | 0 | None | -11 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 513 | 12 | 1 | 5 | 6.2 | COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1 | 10.1016/j.bmc.2010.04.008 | |||
CHEMBL1095197 | 15417 | 0 | None | -11 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 513 | 12 | 1 | 5 | 6.2 | COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1 | 10.1016/j.bmc.2010.04.008 | |||
22718532 | 23555 | 0 | None | 7 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 218 | 4 | 1 | 3 | 1.9 | CC(=O)NCCCc1cccc2ncoc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL124488 | 23555 | 0 | None | 7 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 218 | 4 | 1 | 3 | 1.9 | CC(=O)NCCCc1cccc2ncoc12 | 10.1016/j.bmcl.2004.04.082 | |||
46935150 | 22651 | 0 | None | -6 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 249 | 6 | 1 | 3 | 2.0 | COc1cccc(O[C@@H](C)CNC(=O)C2CC2)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223130 | 22651 | 0 | None | -6 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 249 | 6 | 1 | 3 | 2.0 | COc1cccc(O[C@@H](C)CNC(=O)C2CC2)c1 | 10.1016/j.bmc.2010.06.100 | |||
11463056 | 69176 | 0 | None | 51 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 377 | 6 | 1 | 3 | 5.4 | CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | |||
CHEMBL1779805 | 69176 | 0 | None | 51 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 377 | 6 | 1 | 3 | 5.4 | CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | |||
11638009 | 172542 | 0 | None | 7 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 300 | 5 | 1 | 3 | 3.1 | CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1 | 10.1021/jm0512544 | |||
CHEMBL424693 | 172542 | 0 | None | 7 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 300 | 5 | 1 | 3 | 3.1 | CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1 | 10.1021/jm0512544 | |||
22718602 | 103319 | 0 | None | 2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 274 | 6 | 1 | 3 | 3.1 | CCc1nc2cccc(CCCNC(=O)C(C)C)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL262890 | 103319 | 0 | None | 2 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 274 | 6 | 1 | 3 | 3.1 | CCc1nc2cccc(CCCNC(=O)C(C)C)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
139451761 | 191376 | 0 | None | -4 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 291 | 7 | 1 | 5 | 2.0 | CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | |||
CHEMBL4848885 | 191376 | 0 | None | -4 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 291 | 7 | 1 | 5 | 2.0 | CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O | 10.1021/acs.jmedchem.0c00627 | |||
53310838 | 70565 | 0 | None | 4 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 321 | 4 | 1 | 4 | 2.8 | CC(=O)NCCn1c(-c2ccccc2)nc2ccc3c(c21)CCO3 | 10.1021/jm200385u | |||
CHEMBL1802021 | 70565 | 0 | None | 4 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 321 | 4 | 1 | 4 | 2.8 | CC(=O)NCCn1c(-c2ccccc2)nc2ccc3c(c21)CCO3 | 10.1021/jm200385u | |||
168296374 | 199297 | 0 | None | 2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 505 | 9 | 1 | 8 | 4.5 | CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1 | 10.1021/acs.jmedchem.2c00717 | |||
CHEMBL5209359 | 199297 | 0 | None | 2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 505 | 9 | 1 | 8 | 4.5 | CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1 | 10.1021/acs.jmedchem.2c00717 | |||
145972981 | 171274 | 0 | None | 1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 513 | 13 | 3 | 4 | 6.2 | CC(=O)NCCc1c[nH]c2ccc(OCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12 | 10.1021/acs.jmedchem.8b00893 | |||
CHEMBL4214478 | 171274 | 0 | None | 1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 513 | 13 | 3 | 4 | 6.2 | CC(=O)NCCc1c[nH]c2ccc(OCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12 | 10.1021/acs.jmedchem.8b00893 | |||
44358238 | 126150 | 0 | None | -2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 261 | 2 | 2 | 3 | 1.1 | CNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL344449 | 126150 | 0 | None | -2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 261 | 2 | 2 | 3 | 1.1 | CNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
49865204 | 22622 | 0 | None | -2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 223 | 5 | 1 | 3 | 1.6 | COc1cccc(O[C@@H](C)CNC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223050 | 22622 | 0 | None | -2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 223 | 5 | 1 | 3 | 1.6 | COc1cccc(O[C@@H](C)CNC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
44348996 | 23979 | 0 | None | -1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 272 | 6 | 1 | 3 | 2.8 | CCc1nc2cccc(CCCNC(=O)C3CC3)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL125642 | 23979 | 0 | None | -1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 272 | 6 | 1 | 3 | 2.8 | CCc1nc2cccc(CCCNC(=O)C3CC3)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
44264942 | 212223 | 0 | None | 19 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 313 | 5 | 1 | 4 | 4.0 | CCCC(=O)Nc1ccc(Oc2cccc3c2OCCO3)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL8032 | 212223 | 0 | None | 19 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 313 | 5 | 1 | 4 | 4.0 | CCCC(=O)Nc1ccc(Oc2cccc3c2OCCO3)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
44264844 | 211641 | 0 | None | 2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 296 | 5 | 1 | 3 | 3.8 | COc1cccc(N(C)c2ccc(NC(=O)C3CC3)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7567 | 211641 | 0 | None | 2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 296 | 5 | 1 | 3 | 3.8 | COc1cccc(N(C)c2ccc(NC(=O)C3CC3)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
44424023 | 151592 | 0 | None | 14 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 346 | 9 | 2 | 4 | 3.2 | CCCCCOC(=O)c1[nH]c2ccc(OC)cc2c1CCNC(C)=O | 10.1016/j.bmc.2007.03.080 | |||
CHEMBL390944 | 151592 | 0 | None | 14 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 346 | 9 | 2 | 4 | 3.2 | CCCCCOC(=O)c1[nH]c2ccc(OC)cc2c1CCNC(C)=O | 10.1016/j.bmc.2007.03.080 | |||
53231465 | 69174 | 0 | None | 5 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 237 | 3 | 1 | 2 | 2.7 | CC(=O)NCCc1csc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | |||
CHEMBL1779803 | 69174 | 0 | None | 5 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 237 | 3 | 1 | 2 | 2.7 | CC(=O)NCCc1csc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | |||
86273229 | 128097 | 1 | None | 3 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 244 | 5 | 2 | 2 | 2.0 | C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12 | 10.1021/acs.jmedchem.5b00245 | |||
CHEMBL3580909 | 128097 | 1 | None | 3 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 244 | 5 | 2 | 2 | 2.0 | C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12 | 10.1021/acs.jmedchem.5b00245 | |||
44389864 | 71110 | 0 | None | -4 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 380 | 10 | 2 | 2 | 4.7 | CCNC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
CHEMBL181192 | 71110 | 0 | None | -4 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 380 | 10 | 2 | 2 | 4.7 | CCNC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
44389839 | 71375 | 0 | None | -10 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 379 | 10 | 1 | 2 | 5.1 | CC(C)C(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
CHEMBL181687 | 71375 | 0 | None | -10 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 379 | 10 | 1 | 2 | 5.1 | CC(C)C(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
11165283 | 129910 | 0 | None | -4 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 392 | 9 | 2 | 2 | 4.8 | CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
CHEMBL361206 | 129910 | 0 | None | -4 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 392 | 9 | 2 | 2 | 4.8 | CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
137655489 | 165754 | 0 | None | 7 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 245 | 4 | 2 | 3 | 1.5 | COc1cnc2cccc(CCNC(N)=O)c2c1 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4096197 | 165754 | 0 | None | 7 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 245 | 4 | 2 | 3 | 1.5 | COc1cnc2cccc(CCNC(N)=O)c2c1 | 10.1016/j.ejmech.2016.12.013 | |||
56681902 | 71226 | 0 | None | -10 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 554 | 21 | 2 | 6 | 5.4 | CC(=O)NCCN(C)c1cccc(OCCCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 | 10.1016/j.bmc.2011.06.063 | |||
CHEMBL1813323 | 71226 | 0 | None | -10 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 554 | 21 | 2 | 6 | 5.4 | CC(=O)NCCN(C)c1cccc(OCCCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 | 10.1016/j.bmc.2011.06.063 | |||
54584155 | 67530 | 0 | None | 2 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 366 | 8 | 1 | 5 | 2.8 | COc1ccc2c(CN(C)Cc3ccccc3)cn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | |||
CHEMBL1760949 | 67530 | 0 | None | 2 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 366 | 8 | 1 | 5 | 2.8 | COc1ccc2c(CN(C)Cc3ccccc3)cn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | |||
11501012 | 84017 | 0 | None | 1 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 340 | 5 | 1 | 3 | 3.9 | COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCCC1)cn2C | 10.1021/jm0512544 | |||
CHEMBL207959 | 84017 | 0 | None | 1 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 340 | 5 | 1 | 3 | 3.9 | COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCCC1)cn2C | 10.1021/jm0512544 | |||
16105170 | 196506 | 0 | None | 4 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 5 | 1 | 5 | 3.3 | COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 | 10.1021/jm800974d | |||
CHEMBL515696 | 196506 | 0 | None | 4 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 5 | 1 | 5 | 3.3 | COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 | 10.1021/jm800974d | |||
16105170 | 196506 | 0 | None | 4 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 5 | 1 | 5 | 3.3 | COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 | 10.1016/j.bmc.2009.04.068 | |||
CHEMBL515696 | 196506 | 0 | None | 4 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 5 | 1 | 5 | 3.3 | COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 | 10.1016/j.bmc.2009.04.068 | |||
16743288 | 99102 | 0 | None | 14 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 338 | 5 | 1 | 2 | 4.7 | CCCC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1 | 10.1016/j.ejmech.2007.01.005 | |||
CHEMBL243003 | 99102 | 0 | None | 14 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 338 | 5 | 1 | 2 | 4.7 | CCCC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1 | 10.1016/j.ejmech.2007.01.005 | |||
162649850 | 186917 | 0 | None | 7 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 273 | 6 | 1 | 4 | 2.1 | CCCC(=O)NCCc1ncnc2ccc(OC)cc12 | 10.1016/j.ejmech.2020.112078 | |||
CHEMBL4748822 | 186917 | 0 | None | 7 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 273 | 6 | 1 | 4 | 2.1 | CCCC(=O)NCCc1ncnc2ccc(OC)cc12 | 10.1016/j.ejmech.2020.112078 | |||
162656758 | 187701 | 0 | None | 5 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 259 | 5 | 1 | 4 | 1.7 | CCC(=O)NCCc1ncnc2ccc(OC)cc12 | 10.1016/j.ejmech.2020.112078 | |||
CHEMBL4757920 | 187701 | 0 | None | 5 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 259 | 5 | 1 | 4 | 1.7 | CCC(=O)NCCc1ncnc2ccc(OC)cc12 | 10.1016/j.ejmech.2020.112078 | |||
10637638 | 27373 | 0 | None | -4 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 295 | 5 | 1 | 2 | 3.4 | COc1ccc2cccc3c2c1C(CCNC(=O)C1CC1)C3 | 10.1021/jm000922c | |||
CHEMBL130813 | 27373 | 0 | None | -4 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 295 | 5 | 1 | 2 | 3.4 | COc1ccc2cccc3c2c1C(CCNC(=O)C1CC1)C3 | 10.1021/jm000922c | |||
16105170 | 196506 | 0 | None | 4 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 5 | 1 | 5 | 3.3 | COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 | 10.1021/jm401343c | |||
CHEMBL515696 | 196506 | 0 | None | 4 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 5 | 1 | 5 | 3.3 | COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 | 10.1021/jm401343c | |||
16105170 | 196506 | 0 | None | 4 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 5 | 1 | 5 | 3.3 | COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 | 10.1021/jm800974d | |||
CHEMBL515696 | 196506 | 0 | None | 4 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 5 | 1 | 5 | 3.3 | COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 | 10.1021/jm800974d | |||
16105170 | 196506 | 0 | None | 4 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 5 | 1 | 5 | 3.3 | COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 | 10.1016/j.bmc.2008.07.012 | |||
CHEMBL515696 | 196506 | 0 | None | 4 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 405 | 5 | 1 | 5 | 3.3 | COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21 | 10.1016/j.bmc.2008.07.012 | |||
162647716 | 186666 | 0 | None | 3 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 259 | 5 | 1 | 4 | 1.7 | CCC(=O)NCCc1nncc2ccc(OC)cc12 | 10.1016/j.ejmech.2020.112078 | |||
CHEMBL4745789 | 186666 | 0 | None | 3 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 259 | 5 | 1 | 4 | 1.7 | CCC(=O)NCCc1nncc2ccc(OC)cc12 | 10.1016/j.ejmech.2020.112078 | |||
16094576 | 144910 | 6 | None | 1 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 253 | 5 | 1 | 1 | 3.1 | CC(=O)NCC(Cc1ccccc1)c1ccccc1 | 10.1021/jm060850a | |||
CHEMBL376693 | 144910 | 6 | None | 1 | 2 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 253 | 5 | 1 | 1 | 3.1 | CC(=O)NCC(Cc1ccccc1)c1ccccc1 | 10.1021/jm060850a | |||
45269183 | 202804 | 0 | None | 6 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 385 | 7 | 2 | 3 | 4.1 | COc1ccc2[nH]c(CN(C)c3ccc(Cl)cc3)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2009.04.068 | |||
CHEMBL560186 | 202804 | 0 | None | 6 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 385 | 7 | 2 | 3 | 4.1 | COc1ccc2[nH]c(CN(C)c3ccc(Cl)cc3)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2009.04.068 | |||
10704742 | 114038 | 0 | None | -1 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1cccc2cc(CCNC(C)=O)[nH]c12 | 10.1021/jm001125h | |||
CHEMBL316952 | 114038 | 0 | None | -1 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1cccc2cc(CCNC(C)=O)[nH]c12 | 10.1021/jm001125h | |||
44579261 | 193758 | 0 | None | 87 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 363 | 6 | 2 | 3 | 3.9 | COc1ccc2cc(-c3cccc(C(=O)O)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL490594 | 193758 | 0 | None | 87 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 363 | 6 | 2 | 3 | 3.9 | COc1ccc2cc(-c3cccc(C(=O)O)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
127038131 | 143429 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 363 | 9 | 1 | 3 | 4.4 | CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12 | 10.1039/C5MD00190K | |||
CHEMBL3740052 | 143429 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 363 | 9 | 1 | 3 | 4.4 | CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12 | 10.1039/C5MD00190K | |||
137655126 | 165405 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 260 | 4 | 1 | 4 | 2.1 | COC(=O)NCCc1cccc2ncc(OC)cc12 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4092353 | 165405 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 260 | 4 | 1 | 4 | 2.1 | COC(=O)NCCc1cccc2ncc(OC)cc12 | 10.1016/j.ejmech.2016.12.013 | |||
49865425 | 22732 | 0 | None | -1 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 209 | 4 | 1 | 2 | 2.3 | CC(=O)N[C@@H](C)CSc1ccccc1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223347 | 22732 | 0 | None | -1 | 2 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 209 | 4 | 1 | 2 | 2.3 | CC(=O)N[C@@H](C)CSc1ccccc1 | 10.1016/j.bmc.2010.06.100 | |||
127038131 | 143429 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 363 | 9 | 1 | 3 | 4.4 | CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12 | 10.1039/C5MD00190K | |||
CHEMBL3740052 | 143429 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 363 | 9 | 1 | 3 | 4.4 | CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12 | 10.1039/C5MD00190K | |||
86273222 | 128101 | 0 | None | 3 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 243 | 3 | 1 | 4 | 2.5 | COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
CHEMBL3580913 | 128101 | 0 | None | 3 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 243 | 3 | 1 | 4 | 2.5 | COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
44424022 | 90247 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 718 | 23 | 4 | 8 | 6.9 | COc1ccc2[nH]c(C(=O)OCCCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
CHEMBL220091 | 90247 | 0 | None | -1 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 718 | 23 | 4 | 8 | 6.9 | COc1ccc2[nH]c(C(=O)OCCCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
145964105 | 170997 | 0 | None | -3 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 475 | 12 | 2 | 5 | 4.9 | CC(=O)NCCN(C)c1cccc(OCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
CHEMBL4211018 | 170997 | 0 | None | -3 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 475 | 12 | 2 | 5 | 4.9 | CC(=O)NCCN(C)c1cccc(OCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
122162 | 9166 | 75 | None | 18 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 10.1021/jm980684+ | |||
1363 | 9166 | 75 | None | 18 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 10.1021/jm980684+ | |||
CHEMBL286615 | 9166 | 75 | None | 18 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 10.1021/jm980684+ | |||
10664333 | 214962 | 0 | None | 2 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 332 | 4 | 1 | 2 | 4.3 | CCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2 | 10.1021/jm980684+ | |||
CHEMBL9838 | 214962 | 0 | None | 2 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 332 | 4 | 1 | 2 | 4.3 | CCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2 | 10.1021/jm980684+ | |||
11002150 | 114330 | 0 | None | 7 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 334 | 6 | 1 | 3 | 3.7 | COc1cccc2c1cc(CCNC(=O)C1CC1)n2-c1ccccc1 | 10.1021/jm001125h | |||
CHEMBL318871 | 114330 | 0 | None | 7 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 334 | 6 | 1 | 3 | 3.7 | COc1cccc2c1cc(CCNC(=O)C1CC1)n2-c1ccccc1 | 10.1021/jm001125h | |||
18007928 | 15437 | 0 | None | -5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 485 | 12 | 2 | 4 | 5.5 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CC(=O)O)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
CHEMBL1095504 | 15437 | 0 | None | -5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 485 | 12 | 2 | 4 | 5.5 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CC(=O)O)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
44429455 | 94523 | 0 | None | 2 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 322 | 5 | 1 | 3 | 3.5 | COc1cc(-c2ccccc2)c2c(c1)c(CCNC(C)=O)cn2C | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL233740 | 94523 | 0 | None | 2 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 322 | 5 | 1 | 3 | 3.5 | COc1cc(-c2ccccc2)c2c(c1)c(CCNC(C)=O)cn2C | 10.1016/j.bmc.2007.04.013 | |||
11287002 | 22701 | 2 | None | 4 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 193 | 4 | 1 | 2 | 1.6 | CC(=O)N[C@@H](C)COc1ccccc1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223275 | 22701 | 2 | None | 4 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 193 | 4 | 1 | 2 | 1.6 | CC(=O)N[C@@H](C)COc1ccccc1 | 10.1016/j.bmc.2010.06.100 | |||
3964826 | 22626 | 30 | None | 1 | 2 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 209 | 5 | 1 | 3 | 1.2 | COc1ccc(OCCNC(C)=O)cc1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223054 | 22626 | 30 | None | 1 | 2 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 209 | 5 | 1 | 3 | 1.2 | COc1ccc(OCCNC(C)=O)cc1 | 10.1016/j.bmc.2010.06.100 | |||
127025170 | 144520 | 0 | None | 4 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 312 | 5 | 2 | 3 | 3.5 | CCNC(=O)NCCc1cc2c(ccc3ccc(OC)cc32)o1 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL3759180 | 144520 | 0 | None | 4 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 312 | 5 | 2 | 3 | 3.5 | CCNC(=O)NCCc1cc2c(ccc3ccc(OC)cc32)o1 | 10.1016/j.ejmech.2015.12.047 | |||
162649247 | 186854 | 0 | None | 10 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 351 | 6 | 1 | 5 | 3.0 | COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1 | 10.1016/j.ejmech.2020.112078 | |||
CHEMBL4747996 | 186854 | 0 | None | 10 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 351 | 6 | 1 | 5 | 3.0 | COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1 | 10.1016/j.ejmech.2020.112078 | |||
46885230 | 14965 | 0 | None | 8 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 223 | 5 | 2 | 3 | 1.5 | COc1ccc(O)c(CCCNC(C)=O)c1 | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL1092062 | 14965 | 0 | None | 8 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 223 | 5 | 2 | 3 | 1.5 | COc1ccc(O)c(CCCNC(C)=O)c1 | 10.1016/j.bmcl.2010.02.084 | |||
122162 | 9166 | 75 | None | 18 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 10.1016/j.ejmech.2007.01.005 | |||
1363 | 9166 | 75 | None | 18 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 10.1016/j.ejmech.2007.01.005 | |||
CHEMBL286615 | 9166 | 75 | None | 18 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 10.1016/j.ejmech.2007.01.005 | |||
137656715 | 166326 | 0 | None | 5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 308 | 5 | 1 | 2 | 3.0 | CC(=O)NCC1Cc2ccccc2N(CCc2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | |||
CHEMBL4102517 | 166326 | 0 | None | 5 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 308 | 5 | 1 | 2 | 3.0 | CC(=O)NCC1Cc2ccccc2N(CCc2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | |||
12985496 | 189110 | 0 | None | 31 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 389 | 7 | 2 | 3 | 4.5 | COc1ccc2cc(-c3cccc(CO)c3)cc(CCNC(=O)C3CCC3)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL478438 | 189110 | 0 | None | 31 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 389 | 7 | 2 | 3 | 4.5 | COc1ccc2cc(-c3cccc(CO)c3)cc(CCNC(=O)C3CCC3)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
49865317 | 22666 | 0 | None | 2 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 265 | 6 | 1 | 3 | 2.7 | COc1cccc(S[C@H](C)CNC(=O)C2CC2)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223191 | 22666 | 0 | None | 2 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 265 | 6 | 1 | 3 | 2.7 | COc1cccc(S[C@H](C)CNC(=O)C2CC2)c1 | 10.1016/j.bmc.2010.06.100 | |||
49865374 | 22703 | 0 | None | 7 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 223 | 5 | 1 | 3 | 1.6 | COc1cccc(OC[C@@H](C)NC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223277 | 22703 | 0 | None | 7 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 223 | 5 | 1 | 3 | 1.6 | COc1cccc(OC[C@@H](C)NC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
56653120 | 117646 | 0 | None | -12 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 336 | 8 | 2 | 2 | 3.9 | CC(=O)NCCc1c[nH]c2ccc(OCCCc3ccccc3)cc12 | 10.1021/jm401343c | |||
CHEMBL3260985 | 117646 | 0 | None | -12 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 336 | 8 | 2 | 2 | 3.9 | CC(=O)NCCc1c[nH]c2ccc(OCCCc3ccccc3)cc12 | 10.1021/jm401343c | |||
86273470 | 128100 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 256 | 4 | 1 | 3 | 3.3 | COc1ccc2[nH]cc(CCc3ncc(C)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
CHEMBL3580912 | 128100 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 256 | 4 | 1 | 3 | 3.3 | COc1ccc2[nH]cc(CCc3ncc(C)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
20590653 | 130053 | 0 | None | -5 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 389 | 9 | 1 | 2 | 5.0 | O=C(NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1 | 10.1016/j.bmcl.2005.01.015 | |||
CHEMBL361410 | 130053 | 0 | None | -5 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 389 | 9 | 1 | 2 | 5.0 | O=C(NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1 | 10.1016/j.bmcl.2005.01.015 | |||
54581170 | 67537 | 0 | None | 3 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 359 | 4 | 1 | 4 | 1.8 | COc1ccc2c(I)cn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | |||
CHEMBL1760956 | 67537 | 0 | None | 3 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 359 | 4 | 1 | 4 | 1.8 | COc1ccc2c(I)cn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | |||
127040355 | 144691 | 0 | None | 13 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 410 | 5 | 1 | 4 | 5.5 | COc1ccc2oc(-c3cc4ccccc4c4ccccc34)c(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
CHEMBL3763537 | 144691 | 0 | None | 13 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 410 | 5 | 1 | 4 | 5.5 | COc1ccc2oc(-c3cc4ccccc4c4ccccc34)c(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
127040022 | 144729 | 0 | None | 6 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 410 | 5 | 1 | 4 | 5.5 | COc1ccc2oc(-c3c4ccccc4cc4ccccc34)c(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
CHEMBL3764063 | 144729 | 0 | None | 6 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 410 | 5 | 1 | 4 | 5.5 | COc1ccc2oc(-c3c4ccccc4cc4ccccc34)c(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
10641756 | 105054 | 0 | None | 57 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 352 | 3 | 1 | 2 | 4.6 | CC(=O)NCCc1c2n(c3ccc(Cl)cc13)CCCc1ccccc1-2 | 10.1021/jm980684+ | |||
CHEMBL274630 | 105054 | 0 | None | 57 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 352 | 3 | 1 | 2 | 4.6 | CC(=O)NCCc1c2n(c3ccc(Cl)cc13)CCCc1ccccc1-2 | 10.1021/jm980684+ | |||
16094587 | 90037 | 3 | None | 72 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 297 | 7 | 1 | 2 | 3.7 | CCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1 | 10.1021/jm060850a | |||
CHEMBL218774 | 90037 | 3 | None | 72 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 297 | 7 | 1 | 2 | 3.7 | CCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1 | 10.1021/jm060850a | |||
49865322 | 22671 | 0 | None | 1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 267 | 7 | 1 | 3 | 3.1 | CCCC(=O)NCC(C)Sc1cccc(OC)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223196 | 22671 | 0 | None | 1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 267 | 7 | 1 | 3 | 3.1 | CCCC(=O)NCC(C)Sc1cccc(OC)c1 | 10.1016/j.bmc.2010.06.100 | |||
162674581 | 190091 | 0 | None | 51 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 268 | 3 | 1 | 4 | 2.7 | COc1ccc2cccc(/C=C/c3n[nH]c(=O)o3)c2c1 | 10.1016/j.ejmech.2020.112090 | |||
CHEMBL4797226 | 190091 | 0 | None | 51 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 268 | 3 | 1 | 4 | 2.7 | COc1ccc2cccc(/C=C/c3n[nH]c(=O)o3)c2c1 | 10.1016/j.ejmech.2020.112090 | |||
11351216 | 69178 | 0 | None | 4 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 441 | 6 | 1 | 3 | 5.4 | O=C(CBr)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | |||
CHEMBL1779807 | 69178 | 0 | None | 4 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 441 | 6 | 1 | 3 | 5.4 | O=C(CBr)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12 | 10.1016/j.ejmech.2011.02.044 | |||
22718576 | 121383 | 0 | None | 4 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 232 | 4 | 1 | 3 | 2.2 | CC(=O)NCCCc1cccc2nc(C)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL333810 | 121383 | 0 | None | 4 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 232 | 4 | 1 | 3 | 2.2 | CC(=O)NCCCc1cccc2nc(C)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
3956219 | 108324 | 11 | None | 2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 277 | 5 | 2 | 4 | 1.8 | COc1cc2c(CCNC(C)=O)c[nH]c2cc1[N+](=O)[O-] | 10.1021/jm011053+ | |||
CHEMBL298335 | 108324 | 11 | None | 2 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 277 | 5 | 2 | 4 | 1.8 | COc1cc2c(CCNC(C)=O)c[nH]c2cc1[N+](=O)[O-] | 10.1021/jm011053+ | |||
16094595 | 90036 | 4 | None | 407 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 283 | 6 | 1 | 2 | 3.4 | COc1cccc(C(CCNC(C)=O)c2ccccc2)c1 | 10.1021/jm060850a | |||
CHEMBL218773 | 90036 | 4 | None | 407 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 283 | 6 | 1 | 2 | 3.4 | COc1cccc(C(CCNC(C)=O)c2ccccc2)c1 | 10.1021/jm060850a | |||
23658145 | 164242 | 1 | None | 33 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 287 | 6 | 2 | 3 | 2.5 | CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12 | 10.1039/C4MD00149D | |||
CHEMBL4079214 | 164242 | 1 | None | 33 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 287 | 6 | 2 | 3 | 2.5 | CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12 | 10.1039/C4MD00149D | |||
1347 | 6950 | 56 | None | 1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 248 | 4 | 3 | 3 | 1.6 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1O | 10.1016/j.ejmech.2019.111847 | |||
1864 | 6950 | 56 | None | 1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 248 | 4 | 3 | 3 | 1.6 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1O | 10.1016/j.ejmech.2019.111847 | |||
CHEMBL127421 | 6950 | 56 | None | 1 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 248 | 4 | 3 | 3 | 1.6 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1O | 10.1016/j.ejmech.2019.111847 | |||
44264849 | 212151 | 0 | None | 19 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 298 | 5 | 1 | 3 | 4.1 | COc1cccc(N(C)c2ccc(NC(=O)C(C)C)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7990 | 212151 | 0 | None | 19 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 298 | 5 | 1 | 3 | 4.1 | COc1cccc(N(C)c2ccc(NC(=O)C(C)C)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
10808489 | 214554 | 0 | None | 42 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 360 | 6 | 1 | 3 | 4.1 | CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1 | 10.1021/jm980684+ | |||
CHEMBL9600 | 214554 | 0 | None | 42 | 2 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 360 | 6 | 1 | 3 | 4.1 | CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1 | 10.1021/jm980684+ | |||
90666303 | 116157 | 0 | None | 31 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 361 | 6 | 2 | 3 | 3.9 | COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(C)=O)c2c1 | 10.1039/C1MD00149C | |||
CHEMBL3219324 | 116157 | 0 | None | 31 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 361 | 6 | 2 | 3 | 3.9 | COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(C)=O)c2c1 | 10.1039/C1MD00149C | |||
44358218 | 34289 | 0 | None | 3 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 289 | 4 | 2 | 3 | 1.9 | CCCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL136895 | 34289 | 0 | None | 3 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 289 | 4 | 2 | 3 | 1.9 | CCCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
15453819 | 211762 | 0 | None | 30 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 287 | 6 | 1 | 4 | 3.1 | COCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7659 | 211762 | 0 | None | 30 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 287 | 6 | 1 | 4 | 3.1 | COCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
49865267 | 22648 | 2 | None | 7 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 225 | 5 | 1 | 3 | 1.9 | COc1ccccc1SCCNC(C)=O | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223127 | 22648 | 2 | None | 7 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 225 | 5 | 1 | 3 | 1.9 | COc1ccccc1SCCNC(C)=O | 10.1016/j.bmc.2010.06.100 | |||
7778 | 7601 | 0 | None | -97 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 497 | 12 | 2 | 4 | 6.1 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2 | 10.1016/j.bmc.2010.04.008 | |||
9957516 | 7601 | 0 | None | -97 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 497 | 12 | 2 | 4 | 6.1 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2 | 10.1016/j.bmc.2010.04.008 | |||
CHEMBL1094546 | 7601 | 0 | None | -97 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 497 | 12 | 2 | 4 | 6.1 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2 | 10.1016/j.bmc.2010.04.008 | |||
49865148 | 22603 | 2 | None | 2 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 223 | 5 | 1 | 3 | 1.6 | COc1ccccc1OC(C)CNC(C)=O | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1222984 | 22603 | 2 | None | 2 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 223 | 5 | 1 | 3 | 1.6 | COc1ccccc1OC(C)CNC(C)=O | 10.1016/j.bmc.2010.06.100 | |||
44349269 | 23360 | 1 | None | 3 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 289 | 6 | 2 | 3 | 3.2 | CCNC(=O)NCCCc1cccc2nc(C(C)C)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL123972 | 23360 | 1 | None | 3 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 289 | 6 | 2 | 3 | 3.2 | CCNC(=O)NCCCc1cccc2nc(C(C)C)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
44394456 | 72890 | 0 | None | -2 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 378 | 10 | 2 | 2 | 5.3 | CCNC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL183962 | 72890 | 0 | None | -2 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 378 | 10 | 2 | 2 | 5.3 | CCNC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
23658143 | 163156 | 1 | None | 6 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 291 | 6 | 2 | 3 | 2.0 | COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1 | 10.1039/C4MD00149D | |||
CHEMBL4066279 | 163156 | 1 | None | 6 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 291 | 6 | 2 | 3 | 2.0 | COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1 | 10.1039/C4MD00149D | |||
24750195 | 95329 | 0 | None | 24 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 298 | 6 | 0 | 3 | 3.3 | COc1cccc(N(CCN(C)C(C)=O)c2ccccc2)c1 | 10.1021/jm700957j | |||
CHEMBL235334 | 95329 | 0 | None | 24 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 298 | 6 | 0 | 3 | 3.3 | COc1cccc(N(CCN(C)C(C)=O)c2ccccc2)c1 | 10.1021/jm700957j | |||
11791741 | 214889 | 0 | None | 2 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 344 | 4 | 1 | 2 | 4.3 | O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CC1 | 10.1021/jm980684+ | |||
CHEMBL9791 | 214889 | 0 | None | 2 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 344 | 4 | 1 | 2 | 4.3 | O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CC1 | 10.1021/jm980684+ | |||
16094592 | 90060 | 1 | None | 6 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 251 | 4 | 1 | 1 | 3.4 | CC(=O)NC/C(=C/c1ccccc1)c1ccccc1 | 10.1021/jm060850a | |||
CHEMBL218926 | 90060 | 1 | None | 6 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 251 | 4 | 1 | 1 | 3.4 | CC(=O)NC/C(=C/c1ccccc1)c1ccccc1 | 10.1021/jm060850a | |||
145966403 | 170987 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 497 | 13 | 2 | 6 | 4.9 | CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
CHEMBL4210884 | 170987 | 0 | None | -1 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 497 | 13 | 2 | 6 | 4.9 | CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
122178510 | 128108 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 275 | 4 | 2 | 4 | 3.0 | COc1ccc2[nH]cc(CCc3n[nH]c(=S)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
CHEMBL3580921 | 128108 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 275 | 4 | 2 | 4 | 3.0 | COc1ccc2[nH]cc(CCc3n[nH]c(=S)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
162670470 | 189688 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 343 | 9 | 1 | 5 | 3.7 | CCCCCCn1nc(CCc2c[nH]c3ccc(OC)cc23)oc1=O | 10.1016/j.ejmech.2020.112090 | |||
CHEMBL4792353 | 189688 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 343 | 9 | 1 | 5 | 3.7 | CCCCCCn1nc(CCc2c[nH]c3ccc(OC)cc23)oc1=O | 10.1016/j.ejmech.2020.112090 | |||
86272988 | 128107 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 261 | 3 | 2 | 4 | 2.8 | COc1ccc2[nH]cc(Cc3n[nH]c(=S)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
CHEMBL3580920 | 128107 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 261 | 3 | 2 | 4 | 2.8 | COc1ccc2[nH]cc(Cc3n[nH]c(=S)o3)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
11310062 | 22700 | 2 | None | 1 | 2 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 193 | 4 | 1 | 2 | 1.6 | CC(=O)N[C@H](C)COc1ccccc1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223274 | 22700 | 2 | None | 1 | 2 | Human | 4.3 | pKi | = | 4.3 | Binding | ChEMBL | 193 | 4 | 1 | 2 | 1.6 | CC(=O)N[C@H](C)COc1ccccc1 | 10.1016/j.bmc.2010.06.100 | |||
44394416 | 73012 | 0 | None | -2 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 389 | 9 | 1 | 2 | 5.9 | CC(C)C(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL184562 | 73012 | 0 | None | -2 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 389 | 9 | 1 | 2 | 5.9 | CC(C)C(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
12436516 | 22628 | 6 | None | 2 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 179 | 4 | 1 | 2 | 1.2 | CC(=O)NCCOc1ccccc1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223056 | 22628 | 6 | None | 2 | 2 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 179 | 4 | 1 | 2 | 1.2 | CC(=O)NCCOc1ccccc1 | 10.1016/j.bmc.2010.06.100 | |||
54586060 | 67532 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 332 | 6 | 1 | 6 | 1.0 | COc1ccc2c(CN3CCOCC3)cn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | |||
CHEMBL1760951 | 67532 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 332 | 6 | 1 | 6 | 1.0 | COc1ccc2c(CN3CCOCC3)cn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | |||
137657824 | 166576 | 0 | None | 1 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 289 | 5 | 2 | 3 | 2.3 | CCNC(=S)NCCc1cccc2ncc(OC)cc12 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4105511 | 166576 | 0 | None | 1 | 2 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 289 | 5 | 2 | 3 | 2.3 | CCNC(=S)NCCc1cccc2ncc(OC)cc12 | 10.1016/j.ejmech.2016.12.013 | |||
86272986 | 128109 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 258 | 3 | 2 | 4 | 1.2 | COc1ccc2[nH]cc(Cc3n[nH]c(=O)n3C)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
CHEMBL3580922 | 128109 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 258 | 3 | 2 | 4 | 1.2 | COc1ccc2[nH]cc(Cc3n[nH]c(=O)n3C)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
22718548 | 23273 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 4.2 | CC(C)C(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL123612 | 23273 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 4.2 | CC(C)C(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
11543959 | 83899 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 300 | 6 | 2 | 2 | 3.5 | CCCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1 | 10.1021/jm0512544 | |||
CHEMBL207676 | 83899 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 300 | 6 | 2 | 2 | 3.5 | CCCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1 | 10.1021/jm0512544 | |||
44424026 | 149114 | 0 | None | -1 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 546 | 17 | 4 | 4 | 5.8 | COc1ccc2[nH]cc(CCNC(=O)CCCCCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
CHEMBL388591 | 149114 | 0 | None | -1 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 546 | 17 | 4 | 4 | 5.8 | COc1ccc2[nH]cc(CCNC(=O)CCCCCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
11666721 | 71764 | 0 | None | 18 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 309 | 5 | 1 | 4 | 2.7 | CNC(=O)CCc1c(-c2ccccc2)nc2ccc(OC)cn12 | 10.1016/j.ejmech.2011.06.030 | |||
CHEMBL1823016 | 71764 | 0 | None | 18 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 309 | 5 | 1 | 4 | 2.7 | CNC(=O)CCc1c(-c2ccccc2)nc2ccc(OC)cn12 | 10.1016/j.ejmech.2011.06.030 | |||
127039218 | 144674 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 234 | 4 | 1 | 4 | 1.5 | COc1cc2c(CCNC(C)=O)coc2cn1 | 10.1016/j.ejmech.2016.01.008 | |||
CHEMBL3763247 | 144674 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 234 | 4 | 1 | 4 | 1.5 | COc1cc2c(CCNC(C)=O)coc2cn1 | 10.1016/j.ejmech.2016.01.008 | |||
46845151 | 15438 | 0 | None | -38 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 499 | 12 | 2 | 4 | 6.1 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
CHEMBL1095505 | 15438 | 0 | None | -38 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 499 | 12 | 2 | 4 | 6.1 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
137656978 | 166542 | 0 | None | 147 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 294 | 4 | 1 | 2 | 3.1 | CCC(=O)NC1Cc2ccccc2N(Cc2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | |||
CHEMBL4105125 | 166542 | 0 | None | 147 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 294 | 4 | 1 | 2 | 3.1 | CCC(=O)NC1Cc2ccccc2N(Cc2ccccc2)C1 | 10.1021/acs.jmedchem.8b00359 | |||
137661786 | 165894 | 0 | None | 4 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 262 | 5 | 1 | 3 | 1.9 | COc1cnc2cccc(CCNC(=O)CF)c2c1 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4097693 | 165894 | 0 | None | 4 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 262 | 5 | 1 | 3 | 1.9 | COc1cnc2cccc(CCNC(=O)CF)c2c1 | 10.1016/j.ejmech.2016.12.013 | |||
44394535 | 73787 | 0 | None | -2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 390 | 8 | 1 | 3 | 5.1 | CCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL186977 | 73787 | 0 | None | -2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 390 | 8 | 1 | 3 | 5.1 | CCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 | 10.1016/j.bmcl.2004.07.055 | |||
16094580 | 88333 | 4 | None | 11 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 283 | 6 | 1 | 2 | 3.0 | COc1ccc(Cc2ccccc2)c(CCNC(C)=O)c1 | 10.1021/jm060850a | |||
CHEMBL216158 | 88333 | 4 | None | 11 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 283 | 6 | 1 | 2 | 3.0 | COc1ccc(Cc2ccccc2)c(CCNC(C)=O)c1 | 10.1021/jm060850a | |||
49865324 | 22673 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 267 | 7 | 1 | 3 | 3.1 | CCCC(=O)NC[C@H](C)Sc1cccc(OC)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223198 | 22673 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 267 | 7 | 1 | 3 | 3.1 | CCCC(=O)NC[C@H](C)Sc1cccc(OC)c1 | 10.1016/j.bmc.2010.06.100 | |||
24955342 | 70564 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 321 | 4 | 1 | 4 | 2.6 | CC(=O)NCCc1c(-c2ccccc2)nc2ccc3c(n12)CCO3 | 10.1021/jm200385u | |||
CHEMBL1802020 | 70564 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 321 | 4 | 1 | 4 | 2.6 | CC(=O)NCCc1c(-c2ccccc2)nc2ccc3c(n12)CCO3 | 10.1021/jm200385u | |||
23725513 | 132626 | 0 | None | 3 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 258 | 3 | 1 | 3 | 2.7 | CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
CHEMBL3648357 | 132626 | 0 | None | 3 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 258 | 3 | 1 | 3 | 2.7 | CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21 | 10.1021/acs.jmedchem.0c01836 | |||
10760155 | 105195 | 0 | None | 43 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 348 | 4 | 1 | 3 | 3.9 | COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1 | 10.1021/jm980684+ | |||
CHEMBL275529 | 105195 | 0 | None | 43 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 348 | 4 | 1 | 3 | 3.9 | COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1 | 10.1021/jm980684+ | |||
145976009 | 170311 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 541 | 15 | 3 | 4 | 7.0 | CC(=O)NCCc1c[nH]c2ccc(OCCCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12 | 10.1021/acs.jmedchem.8b00893 | |||
CHEMBL4202816 | 170311 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 541 | 15 | 3 | 4 | 7.0 | CC(=O)NCCc1c[nH]c2ccc(OCCCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12 | 10.1021/acs.jmedchem.8b00893 | |||
44358312 | 36595 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 274 | 3 | 1 | 3 | 2.0 | CC(C)C(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL138744 | 36595 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 274 | 3 | 1 | 3 | 2.0 | CC(C)C(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
10829695 | 125983 | 0 | None | 21 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 3.4 | COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1 | 10.1021/jm020982d | |||
CHEMBL34327 | 125983 | 0 | None | 21 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 3.4 | COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1 | 10.1021/jm020982d | |||
10829695 | 125983 | 0 | None | 21 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 3.4 | COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1 | 10.1021/jm048956y | |||
CHEMBL34327 | 125983 | 0 | None | 21 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 3.4 | COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1 | 10.1021/jm048956y | |||
10596576 | 10945 | 0 | None | 39 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 390 | 7 | 1 | 3 | 5.1 | CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)CCCc1ccccc1-2 | 10.1021/jm980684+ | |||
CHEMBL10007 | 10945 | 0 | None | 39 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 390 | 7 | 1 | 3 | 5.1 | CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)CCCc1ccccc1-2 | 10.1021/jm980684+ | |||
71540395 | 93191 | 0 | None | -2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 256 | 3 | 2 | 2 | 2.7 | CNC(=O)N/C=C/c1c(OC)ccc2ccccc12 | 10.1016/j.bmcl.2012.11.069 | |||
CHEMBL2314258 | 93191 | 0 | None | -2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 256 | 3 | 2 | 2 | 2.7 | CNC(=O)N/C=C/c1c(OC)ccc2ccccc12 | 10.1016/j.bmcl.2012.11.069 | |||
10163052 | 15293 | 0 | None | -72 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 483 | 12 | 2 | 4 | 5.9 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
CHEMBL1094212 | 15293 | 0 | None | -72 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 483 | 12 | 2 | 4 | 5.9 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
44317725 | 212450 | 0 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 329 | 9 | 1 | 3 | 4.1 | CCCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC | 10.1016/S0960-894X(97)00444-7 | |||
CHEMBL82135 | 212450 | 0 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 329 | 9 | 1 | 3 | 4.1 | CCCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC | 10.1016/S0960-894X(97)00444-7 | |||
49865318 | 22667 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 265 | 6 | 1 | 3 | 2.7 | COc1cccc(S[C@@H](C)CNC(=O)C2CC2)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223192 | 22667 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 265 | 6 | 1 | 3 | 2.7 | COc1cccc(S[C@@H](C)CNC(=O)C2CC2)c1 | 10.1016/j.bmc.2010.06.100 | |||
18360631 | 15487 | 0 | None | -26 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 516 | 13 | 2 | 4 | 5.7 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4c(c3)C(CCNC(C)=O)CCC4)cc12 | 10.1016/j.bmc.2010.04.008 | |||
CHEMBL1095831 | 15487 | 0 | None | -26 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 516 | 13 | 2 | 4 | 5.7 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4c(c3)C(CCNC(C)=O)CCC4)cc12 | 10.1016/j.bmc.2010.04.008 | |||
9881917 | 103816 | 0 | None | 44 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 271 | 5 | 1 | 3 | 3.8 | CCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL266970 | 103816 | 0 | None | 44 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 271 | 5 | 1 | 3 | 3.8 | CCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
71540275 | 93184 | 0 | None | 2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 225 | 2 | 1 | 1 | 2.8 | CC(=O)N[C@@H]1C[C@H]1c1cccc2ccccc12 | 10.1016/j.bmcl.2012.11.069 | |||
CHEMBL2314250 | 93184 | 0 | None | 2 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 225 | 2 | 1 | 1 | 2.8 | CC(=O)N[C@@H]1C[C@H]1c1cccc2ccccc12 | 10.1016/j.bmcl.2012.11.069 | |||
44241665 | 202479 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 329 | 6 | 1 | 4 | 2.6 | CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCN(C)C2 | 10.1016/j.bmc.2009.04.068 | |||
CHEMBL556908 | 202479 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 329 | 6 | 1 | 4 | 2.6 | CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCN(C)C2 | 10.1016/j.bmc.2009.04.068 | |||
168288029 | 198400 | 0 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 471 | 9 | 1 | 9 | 3.4 | COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | |||
CHEMBL5195595 | 198400 | 0 | None | 1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 471 | 9 | 1 | 9 | 3.4 | COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-] | 10.1021/acs.jmedchem.2c00717 | |||
10384120 | 131169 | 0 | None | -7 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 363 | 10 | 1 | 2 | 5.5 | CCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL363936 | 131169 | 0 | None | -7 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 363 | 10 | 1 | 2 | 5.5 | CCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
25022442 | 196338 | 0 | None | 5 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 375 | 4 | 1 | 4 | 3.3 | COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1 | 10.1021/jm800974d | |||
CHEMBL514413 | 196338 | 0 | None | 5 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 375 | 4 | 1 | 4 | 3.3 | COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1 | 10.1021/jm800974d | |||
145977894 | 170628 | 0 | None | -3 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 372 | 11 | 2 | 5 | 3.2 | CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(O)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
CHEMBL4206516 | 170628 | 0 | None | -3 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 372 | 11 | 2 | 5 | 3.2 | CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(O)c2)c1 | 10.1021/acs.jmedchem.8b00893 | |||
11314110 | 77513 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 350 | 6 | 1 | 3 | 4.3 | CCC(=O)NCc1cc2c(OC)cccc2n1Cc1c(C)cccc1C | 10.1021/jm048956y | |||
CHEMBL195074 | 77513 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 350 | 6 | 1 | 3 | 4.3 | CCC(=O)NCc1cc2c(OC)cccc2n1Cc1c(C)cccc1C | 10.1021/jm048956y | |||
44349294 | 25325 | 1 | None | 5 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 323 | 6 | 2 | 3 | 3.7 | CCNC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL127576 | 25325 | 1 | None | 5 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 323 | 6 | 2 | 3 | 3.7 | CCNC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
44429453 | 94316 | 0 | None | -1 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 322 | 6 | 2 | 2 | 3.9 | CCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL233517 | 94316 | 0 | None | -1 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 322 | 6 | 2 | 2 | 3.9 | CCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
11500596 | 145457 | 0 | None | 7 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 312 | 5 | 2 | 2 | 3.5 | COc1ccc2[nH]cc(C3(CNC(=O)C4CCC4)CCC3)c2c1 | 10.1021/jm0512544 | |||
CHEMBL377809 | 145457 | 0 | None | 7 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 312 | 5 | 2 | 2 | 3.5 | COc1ccc2[nH]cc(C3(CNC(=O)C4CCC4)CCC3)c2c1 | 10.1021/jm0512544 | |||
44424018 | 92133 | 0 | None | -3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 620 | 16 | 4 | 8 | 4.2 | COc1ccc2[nH]c(C(=O)OCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
CHEMBL226162 | 92133 | 0 | None | -3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 620 | 16 | 4 | 8 | 4.2 | COc1ccc2[nH]c(C(=O)OCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
45268310 | 203342 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 419 | 7 | 2 | 3 | 4.5 | COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2009.04.068 | |||
CHEMBL563847 | 203342 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 419 | 7 | 2 | 3 | 4.5 | COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2009.04.068 | |||
10807560 | 214926 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 346 | 5 | 1 | 2 | 4.7 | CCCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2 | 10.1021/jm980684+ | |||
CHEMBL9815 | 214926 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 346 | 5 | 1 | 2 | 4.7 | CCCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2 | 10.1021/jm980684+ | |||
45268310 | 203342 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 419 | 7 | 2 | 3 | 4.5 | COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2009.04.068 | |||
CHEMBL563847 | 203342 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 419 | 7 | 2 | 3 | 4.5 | COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2009.04.068 | |||
44264689 | 211830 | 1 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 282 | 5 | 2 | 3 | 3.8 | COc1cccc(Nc2ccc(NC(=O)C3CC3)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7713 | 211830 | 1 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 282 | 5 | 2 | 3 | 3.8 | COc1cccc(Nc2ccc(NC(=O)C3CC3)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
25022442 | 196338 | 0 | None | 5 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 375 | 4 | 1 | 4 | 3.3 | COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1 | 10.1016/j.bmc.2009.04.068 | |||
CHEMBL514413 | 196338 | 0 | None | 5 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 375 | 4 | 1 | 4 | 3.3 | COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1 | 10.1016/j.bmc.2009.04.068 | |||
10563168 | 126470 | 0 | None | -1 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 258 | 4 | 2 | 2 | 2.6 | COc1cccc2[nH]c(CNC(=O)C3CCC3)cc12 | 10.1021/jm001125h | |||
CHEMBL34729 | 126470 | 0 | None | -1 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 258 | 4 | 2 | 2 | 2.6 | COc1cccc2[nH]c(CNC(=O)C3CCC3)cc12 | 10.1021/jm001125h | |||
49865424 | 22731 | 0 | None | 1 | 2 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 209 | 4 | 1 | 2 | 2.3 | CC(=O)N[C@H](C)CSc1ccccc1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223346 | 22731 | 0 | None | 1 | 2 | Human | 4.2 | pKi | = | 4.2 | Binding | ChEMBL | 209 | 4 | 1 | 2 | 2.3 | CC(=O)N[C@H](C)CSc1ccccc1 | 10.1016/j.bmc.2010.06.100 | |||
25022442 | 196338 | 0 | None | 5 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 375 | 4 | 1 | 4 | 3.3 | COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1 | 10.1021/jm800974d | |||
CHEMBL514413 | 196338 | 0 | None | 5 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 375 | 4 | 1 | 4 | 3.3 | COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1 | 10.1021/jm800974d | |||
44424019 | 92134 | 0 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 648 | 18 | 4 | 8 | 5.0 | COc1ccc2[nH]c(C(=O)OCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
CHEMBL226163 | 92134 | 0 | None | 3 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 648 | 18 | 4 | 8 | 5.0 | COc1ccc2[nH]c(C(=O)OCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
25022442 | 196338 | 0 | None | 5 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 375 | 4 | 1 | 4 | 3.3 | COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1 | 10.1016/j.bmc.2008.07.012 | |||
CHEMBL514413 | 196338 | 0 | None | 5 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 375 | 4 | 1 | 4 | 3.3 | COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1 | 10.1016/j.bmc.2008.07.012 | |||
11536746 | 146229 | 0 | None | 2 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 300 | 4 | 1 | 3 | 3.1 | COc1ccc2c(c1)c(C1(CNC(C)=O)CCCC1)cn2C | 10.1021/jm0512544 | |||
CHEMBL379403 | 146229 | 0 | None | 2 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 300 | 4 | 1 | 3 | 3.1 | COc1ccc2c(c1)c(C1(CNC(C)=O)CCCC1)cn2C | 10.1021/jm0512544 | |||
45267465 | 201546 | 0 | None | 1 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 365 | 8 | 2 | 3 | 3.5 | COc1ccc2[nH]c(CN(C)Cc3ccccc3)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2009.04.068 | |||
CHEMBL538129 | 201546 | 0 | None | 1 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 365 | 8 | 2 | 3 | 3.5 | COc1ccc2[nH]c(CN(C)Cc3ccccc3)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2009.04.068 | |||
16094579 | 87617 | 5 | None | -1 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 267 | 6 | 1 | 1 | 3.3 | CCC(=O)NCCc1cccc(Cc2ccccc2)c1 | 10.1021/jm060850a | |||
CHEMBL215252 | 87617 | 5 | None | -1 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 267 | 6 | 1 | 1 | 3.3 | CCC(=O)NCCc1cccc(Cc2ccccc2)c1 | 10.1021/jm060850a | |||
49865205 | 22624 | 0 | None | 4 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 239 | 5 | 1 | 3 | 2.3 | COc1cccc(S[C@H](C)CNC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223052 | 22624 | 0 | None | 4 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 239 | 5 | 1 | 3 | 2.3 | COc1cccc(S[C@H](C)CNC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
4207624 | 22627 | 37 | None | 5 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 209 | 5 | 1 | 3 | 1.2 | COc1ccccc1OCCNC(C)=O | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223055 | 22627 | 37 | None | 5 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 209 | 5 | 1 | 3 | 1.2 | COc1ccccc1OCCNC(C)=O | 10.1016/j.bmc.2010.06.100 | |||
49865320 | 22669 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 251 | 7 | 1 | 3 | 2.4 | CCCC(=O)NC[C@@H](C)Oc1cccc(OC)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223194 | 22669 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 251 | 7 | 1 | 3 | 2.4 | CCCC(=O)NC[C@@H](C)Oc1cccc(OC)c1 | 10.1016/j.bmc.2010.06.100 | |||
44436051 | 158142 | 6 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 209 | 5 | 1 | 3 | 1.2 | COc1cccc(OCCNC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL396132 | 158142 | 6 | None | -1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 209 | 5 | 1 | 3 | 1.2 | COc1cccc(OCCNC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
44429456 | 94704 | 0 | None | 8 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 336 | 6 | 1 | 3 | 3.9 | CCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL233945 | 94704 | 0 | None | 8 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 336 | 6 | 1 | 3 | 3.9 | CCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
49865423 | 22730 | 2 | None | 4 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 209 | 4 | 1 | 2 | 2.3 | CC(=O)NC(C)CSc1ccccc1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223345 | 22730 | 2 | None | 4 | 2 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 209 | 4 | 1 | 2 | 2.3 | CC(=O)NC(C)CSc1ccccc1 | 10.1016/j.bmc.2010.06.100 | |||
122178508 | 128104 | 0 | None | 8 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 243 | 4 | 1 | 4 | 2.3 | COc1ccc2[nH]cc(CCc3nnco3)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
CHEMBL3580917 | 128104 | 0 | None | 8 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 243 | 4 | 1 | 4 | 2.3 | COc1ccc2[nH]cc(CCc3nnco3)c2c1 | 10.1021/acs.jmedchem.5b00245 | |||
162672373 | 189866 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 298 | 4 | 1 | 5 | 2.7 | COc1cc2cccc(/C=C/c3n[nH]c(=O)o3)c2cc1OC | 10.1016/j.ejmech.2020.112090 | |||
CHEMBL4794450 | 189866 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 298 | 4 | 1 | 5 | 2.7 | COc1cc2cccc(/C=C/c3n[nH]c(=O)o3)c2cc1OC | 10.1016/j.ejmech.2020.112090 | |||
46884554 | 15070 | 0 | None | 128 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 313 | 8 | 1 | 3 | 3.3 | COc1cc(CCCNC(C)=O)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL1092647 | 15070 | 0 | None | 128 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 313 | 8 | 1 | 3 | 3.3 | COc1cc(CCCNC(C)=O)ccc1OCc1ccccc1 | 10.1016/j.bmcl.2010.02.084 | |||
127027022 | 144587 | 0 | None | 19 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 314 | 4 | 2 | 3 | 3.6 | CCNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1 | 10.1016/j.ejmech.2015.12.047 | |||
CHEMBL3759677 | 144587 | 0 | None | 19 | 3 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 314 | 4 | 2 | 3 | 3.6 | CCNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1 | 10.1016/j.ejmech.2015.12.047 | |||
10104923 | 108277 | 2 | None | 12 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 221 | 6 | 1 | 2 | 2.2 | CCC(=O)NCCCc1cccc(OC)c1 | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL297947 | 108277 | 2 | None | 12 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 221 | 6 | 1 | 2 | 2.2 | CCC(=O)NCCCc1cccc(OC)c1 | 10.1016/j.bmcl.2010.02.084 | |||
25209998 | 196521 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 393 | 7 | 2 | 4 | 3.4 | COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O | 10.1021/jm800974d | |||
CHEMBL515856 | 196521 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 393 | 7 | 2 | 4 | 3.4 | COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O | 10.1021/jm800974d | |||
49865206 | 22625 | 1 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 239 | 5 | 1 | 3 | 2.3 | COc1cccc(S[C@@H](C)CNC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223053 | 22625 | 1 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 239 | 5 | 1 | 3 | 2.3 | COc1cccc(S[C@@H](C)CNC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
25209998 | 196521 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 393 | 7 | 2 | 4 | 3.4 | COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O | 10.1021/jm800974d | |||
CHEMBL515856 | 196521 | 0 | None | -1 | 2 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 393 | 7 | 2 | 4 | 3.4 | COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O | 10.1021/jm800974d | |||
44264843 | 211626 | 0 | None | 4 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 300 | 5 | 1 | 4 | 4.0 | CCOC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7556 | 211626 | 0 | None | 4 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 300 | 5 | 1 | 4 | 4.0 | CCOC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1 | 10.1016/j.bmcl.2003.11.030 | |||
44394508 | 72919 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 404 | 9 | 1 | 3 | 5.5 | CCCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL184144 | 72919 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 404 | 9 | 1 | 3 | 5.5 | CCCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 | 10.1016/j.bmcl.2004.07.055 | |||
18466111 | 26617 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 283 | 5 | 1 | 2 | 3.4 | CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
CHEMBL130214 | 26617 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 283 | 5 | 1 | 2 | 3.4 | CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23 | 10.1021/jm000922c | |||
24750070 | 160332 | 4 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 208 | 5 | 2 | 3 | 1.2 | COc1cccc(NCCNC(C)=O)c1 | 10.1021/jm700957j | |||
CHEMBL398017 | 160332 | 4 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 208 | 5 | 2 | 3 | 1.2 | COc1cccc(NCCNC(C)=O)c1 | 10.1021/jm700957j | |||
11688043 | 84770 | 0 | None | 28 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 300 | 6 | 1 | 3 | 3.1 | CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1 | 10.1021/jm0512544 | |||
CHEMBL209712 | 84770 | 0 | None | 28 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 300 | 6 | 1 | 3 | 3.1 | CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1 | 10.1021/jm0512544 | |||
44579296 | 193573 | 0 | None | 5 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 376 | 6 | 2 | 3 | 4.2 | COc1ccc2cc(-c3cccc(NC(C)=O)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL489170 | 193573 | 0 | None | 5 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 376 | 6 | 2 | 3 | 4.2 | COc1ccc2cc(-c3cccc(NC(C)=O)c3)cc(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.08.052 | |||
10639585 | 121241 | 0 | None | 83 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 3.7 | CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccccc1 | 10.1021/jm001125h | |||
CHEMBL33346 | 121241 | 0 | None | 83 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 322 | 6 | 1 | 3 | 3.7 | CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccccc1 | 10.1021/jm001125h | |||
44349362 | 23346 | 0 | None | 5 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 286 | 7 | 1 | 3 | 3.2 | CCCc1nc2cccc(CCCNC(=O)C3CC3)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL123899 | 23346 | 0 | None | 5 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 286 | 7 | 1 | 3 | 3.2 | CCCc1nc2cccc(CCCNC(=O)C3CC3)c2o1 | 10.1016/j.bmcl.2004.04.082 | |||
44424020 | 92137 | 0 | None | 7 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 676 | 20 | 4 | 8 | 5.8 | COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
CHEMBL226171 | 92137 | 0 | None | 7 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 676 | 20 | 4 | 8 | 5.8 | COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
10518884 | 119331 | 0 | None | 11 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 308 | 5 | 1 | 3 | 3.3 | COc1cccc2c1cc(CCNC(C)=O)n2-c1ccccc1 | 10.1021/jm001125h | |||
CHEMBL329979 | 119331 | 0 | None | 11 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 308 | 5 | 1 | 3 | 3.3 | COc1cccc2c1cc(CCNC(C)=O)n2-c1ccccc1 | 10.1021/jm001125h | |||
127041168 | 143382 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 388 | 10 | 2 | 3 | 3.9 | O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F | 10.1039/C5MD00190K | |||
CHEMBL3739674 | 143382 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 388 | 10 | 2 | 3 | 3.9 | O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F | 10.1039/C5MD00190K | |||
45268303 | 203524 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 301 | 4 | 1 | 4 | 1.8 | COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCN(C)C1 | 10.1016/j.bmc.2009.04.068 | |||
CHEMBL565176 | 203524 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 301 | 4 | 1 | 4 | 1.8 | COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCN(C)C1 | 10.1016/j.bmc.2009.04.068 | |||
127041168 | 143382 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 388 | 10 | 2 | 3 | 3.9 | O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F | 10.1039/C5MD00190K | |||
CHEMBL3739674 | 143382 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 388 | 10 | 2 | 3 | 3.9 | O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F | 10.1039/C5MD00190K | |||
25022429 | 194928 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 393 | 7 | 3 | 4 | 2.8 | COc1ccc2[nH]c(CN3c4ccccc4C[C@H]3CO)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.07.012 | |||
CHEMBL498493 | 194928 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 393 | 7 | 3 | 4 | 2.8 | COc1ccc2[nH]c(CN3c4ccccc4C[C@H]3CO)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2008.07.012 | |||
16750566 | 148810 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 662 | 19 | 4 | 8 | 5.4 | COc1ccc2[nH]c(C(=O)OCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
CHEMBL387655 | 148810 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 662 | 19 | 4 | 8 | 5.4 | COc1ccc2[nH]c(C(=O)OCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
16743124 | 98984 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 282 | 5 | 1 | 2 | 3.0 | O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CC1 | 10.1016/j.ejmech.2007.01.005 | |||
CHEMBL242573 | 98984 | 0 | None | 1 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 282 | 5 | 1 | 2 | 3.0 | O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CC1 | 10.1016/j.ejmech.2007.01.005 | |||
11616210 | 146236 | 0 | None | 6 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 286 | 4 | 1 | 3 | 2.7 | COc1ccc2c(c1)c(C1(CNC(C)=O)CCC1)cn2C | 10.1021/jm0512544 | |||
CHEMBL379413 | 146236 | 0 | None | 6 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 286 | 4 | 1 | 3 | 2.7 | COc1ccc2c(c1)c(C1(CNC(C)=O)CCC1)cn2C | 10.1021/jm0512544 | |||
46885287 | 14941 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 341 | 10 | 1 | 3 | 3.8 | COc1ccc(OCCCc2ccccc2)c(CCCNC(C)=O)c1 | 10.1016/j.bmcl.2010.02.084 | |||
CHEMBL1091896 | 14941 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 341 | 10 | 1 | 3 | 3.8 | COc1ccc(OCCCc2ccccc2)c(CCCNC(C)=O)c1 | 10.1016/j.bmcl.2010.02.084 | |||
1355 | 10211 | 5 | None | -70 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1021/jm0255872 | |||
9806449 | 10211 | 5 | None | -70 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1021/jm0255872 | |||
CHEMBL14453 | 10211 | 5 | None | -70 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1021/jm0255872 | |||
1355 | 10211 | 5 | None | -70 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1016/j.bmc.2010.04.008 | |||
9806449 | 10211 | 5 | None | -70 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1016/j.bmc.2010.04.008 | |||
CHEMBL14453 | 10211 | 5 | None | -70 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1016/j.bmc.2010.04.008 | |||
44424025 | 91949 | 0 | None | -1 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 504 | 14 | 4 | 4 | 4.6 | COc1ccc2[nH]cc(CCNC(=O)CCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
CHEMBL225302 | 91949 | 0 | None | -1 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 504 | 14 | 4 | 4 | 4.6 | COc1ccc2[nH]cc(CCNC(=O)CCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1 | 10.1016/j.bmc.2007.03.080 | |||
137633839 | 163389 | 0 | None | 7 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 273 | 5 | 2 | 3 | 2.1 | CCNC(=O)NCCc1cccc2ncc(OC)cc12 | 10.1016/j.ejmech.2016.12.013 | |||
CHEMBL4068922 | 163389 | 0 | None | 7 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 273 | 5 | 2 | 3 | 2.1 | CCNC(=O)NCCc1cccc2ncc(OC)cc12 | 10.1016/j.ejmech.2016.12.013 | |||
10526493 | 212073 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 427 | 8 | 1 | 3 | 3.7 | CCC(=O)NCCc1c(OCCI)ccc2ccc(OC)cc12 | 10.1016/S0960-894X(97)00444-7 | |||
CHEMBL79224 | 212073 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 427 | 8 | 1 | 3 | 3.7 | CCC(=O)NCCc1c(OCCI)ccc2ccc(OC)cc12 | 10.1016/S0960-894X(97)00444-7 | |||
1355 | 10211 | 5 | None | -70 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1021/jm401343c | |||
9806449 | 10211 | 5 | None | -70 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1021/jm401343c | |||
CHEMBL14453 | 10211 | 5 | None | -70 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1021/jm401343c | |||
1355 | 10211 | 5 | None | -70 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1039/C5MD00190K | |||
9806449 | 10211 | 5 | None | -70 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1039/C5MD00190K | |||
CHEMBL14453 | 10211 | 5 | None | -70 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 10.1039/C5MD00190K | |||
54582194 | 67531 | 0 | None | -1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 330 | 6 | 1 | 5 | 2.2 | COc1ccc2c(CN3CCCCC3)cn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | |||
CHEMBL1760950 | 67531 | 0 | None | -1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 330 | 6 | 1 | 5 | 2.2 | COc1ccc2c(CN3CCCCC3)cn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | |||
54583161 | 67534 | 0 | None | 1 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 452 | 8 | 1 | 6 | 3.4 | COc1ccc2c(CN3CCC(C(=O)c4ccc(F)cc4)CC3)cn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | |||
CHEMBL1760953 | 67534 | 0 | None | 1 | 2 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 452 | 8 | 1 | 6 | 3.4 | COc1ccc2c(CN3CCC(C(=O)c4ccc(F)cc4)CC3)cn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | |||
10849065 | 6925 | 8 | None | -4 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 262 | 6 | 3 | 3 | 1.2 | OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
1345 | 6925 | 8 | None | -4 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 262 | 6 | 3 | 3 | 1.2 | OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
CHEMBL126809 | 6925 | 8 | None | -4 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 262 | 6 | 3 | 3 | 1.2 | OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10.1016/j.ejmech.2019.111847 | |||
11109646 | 213851 | 0 | None | 7 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 309 | 5 | 2 | 3 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(O)cc12 | 10.1021/jm0005252 | |||
CHEMBL91813 | 213851 | 0 | None | 7 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 309 | 5 | 2 | 3 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(O)cc12 | 10.1021/jm0005252 | |||
54770909 | 71766 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 339 | 6 | 2 | 5 | 2.0 | COc1ccc2nc(-c3ccccc3)c(CC(CO)NC(C)=O)n2c1 | 10.1016/j.ejmech.2011.06.030 | |||
CHEMBL1823018 | 71766 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 339 | 6 | 2 | 5 | 2.0 | COc1ccc2nc(-c3ccccc3)c(CC(CO)NC(C)=O)n2c1 | 10.1016/j.ejmech.2011.06.030 | |||
162658247 | 187797 | 0 | None | 2 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 245 | 4 | 1 | 4 | 1.3 | COc1ccc2cnnc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2020.112078 | |||
CHEMBL4759137 | 187797 | 0 | None | 2 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 245 | 4 | 1 | 4 | 1.3 | COc1ccc2cnnc(CCNC(C)=O)c2c1 | 10.1016/j.ejmech.2020.112078 | |||
12071674 | 130721 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 351 | 9 | 1 | 2 | 4.5 | CC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
CHEMBL362849 | 130721 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 351 | 9 | 1 | 2 | 4.5 | CC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
25209861 | 181998 | 0 | None | 5 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 405 | 8 | 2 | 3 | 4.6 | CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12 | 10.1021/jm800974d | |||
CHEMBL457138 | 181998 | 0 | None | 5 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 405 | 8 | 2 | 3 | 4.6 | CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12 | 10.1021/jm800974d | |||
11702296 | 71765 | 6 | None | 3 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 309 | 5 | 1 | 4 | 2.7 | COc1ccc2nc(-c3ccccc3)c(CCNC(C)=O)n2c1 | 10.1016/j.ejmech.2011.06.030 | |||
CHEMBL1823017 | 71765 | 6 | None | 3 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 309 | 5 | 1 | 4 | 2.7 | COc1ccc2nc(-c3ccccc3)c(CCNC(C)=O)n2c1 | 10.1016/j.ejmech.2011.06.030 | |||
127041169 | 143626 | 0 | None | -6 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 570 | 14 | 2 | 4 | 5.7 | O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F | 10.1039/C5MD00190K | |||
CHEMBL3741890 | 143626 | 0 | None | -6 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 570 | 14 | 2 | 4 | 5.7 | O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F | 10.1039/C5MD00190K | |||
127041169 | 143626 | 0 | None | -6 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 570 | 14 | 2 | 4 | 5.7 | O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F | 10.1039/C5MD00190K | |||
CHEMBL3741890 | 143626 | 0 | None | -6 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 570 | 14 | 2 | 4 | 5.7 | O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F | 10.1039/C5MD00190K | |||
25209861 | 181998 | 0 | None | 5 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 405 | 8 | 2 | 3 | 4.6 | CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12 | 10.1021/jm800974d | |||
CHEMBL457138 | 181998 | 0 | None | 5 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 405 | 8 | 2 | 3 | 4.6 | CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12 | 10.1021/jm800974d | |||
10969292 | 214611 | 0 | None | 7 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 321 | 6 | 1 | 2 | 4.3 | CCc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
CHEMBL96333 | 214611 | 0 | None | 7 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 321 | 6 | 1 | 2 | 4.3 | CCc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
44579164 | 188909 | 0 | None | 14 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 406 | 7 | 2 | 4 | 4.8 | CCOC(=O)Nc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 | 10.1016/j.bmc.2008.08.052 | |||
CHEMBL478218 | 188909 | 0 | None | 14 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 406 | 7 | 2 | 4 | 4.8 | CCOC(=O)Nc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 | 10.1016/j.bmc.2008.08.052 | |||
46888520 | 15415 | 0 | None | -10 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 538 | 15 | 2 | 4 | 6.1 | C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
CHEMBL1095195 | 15415 | 0 | None | -10 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 538 | 15 | 2 | 4 | 6.1 | C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
10428383 | 10685 | 5 | None | 151 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 356 | 6 | 1 | 3 | 4.4 | CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC | 10.1021/jm401343c | |||
7783 | 10685 | 5 | None | 151 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 356 | 6 | 1 | 3 | 4.4 | CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC | 10.1021/jm401343c | |||
CHEMBL33185 | 10685 | 5 | None | 151 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 356 | 6 | 1 | 3 | 4.4 | CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC | 10.1021/jm401343c | |||
10428383 | 10685 | 5 | None | 151 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 356 | 6 | 1 | 3 | 4.4 | CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC | 10.1021/jm001125h | |||
7783 | 10685 | 5 | None | 151 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 356 | 6 | 1 | 3 | 4.4 | CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC | 10.1021/jm001125h | |||
CHEMBL33185 | 10685 | 5 | None | 151 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 356 | 6 | 1 | 3 | 4.4 | CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC | 10.1021/jm001125h | |||
10428383 | 10685 | 5 | None | 151 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 356 | 6 | 1 | 3 | 4.4 | CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC | 10.1021/jm048956y | |||
7783 | 10685 | 5 | None | 151 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 356 | 6 | 1 | 3 | 4.4 | CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC | 10.1021/jm048956y | |||
CHEMBL33185 | 10685 | 5 | None | 151 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 356 | 6 | 1 | 3 | 4.4 | CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC | 10.1021/jm048956y | |||
127038132 | 143592 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 361 | 9 | 1 | 2 | 4.9 | CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12 | 10.1039/C5MD00190K | |||
CHEMBL3741561 | 143592 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 361 | 9 | 1 | 2 | 4.9 | CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12 | 10.1039/C5MD00190K | |||
90666304 | 116158 | 0 | None | -1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 401 | 7 | 2 | 3 | 4.6 | COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(=O)C3CCC3)c2c1 | 10.1039/C1MD00149C | |||
CHEMBL3219325 | 116158 | 0 | None | -1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 401 | 7 | 2 | 3 | 4.6 | COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(=O)C3CCC3)c2c1 | 10.1039/C1MD00149C | |||
10656443 | 215154 | 2 | None | 1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 218 | 3 | 2 | 2 | 1.8 | COc1cccc2[nH]c(CNC(C)=O)cc12 | 10.1021/jm001125h | |||
CHEMBL99534 | 215154 | 2 | None | 1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 218 | 3 | 2 | 2 | 1.8 | COc1cccc2[nH]c(CNC(C)=O)cc12 | 10.1021/jm001125h | |||
56678563 | 71223 | 0 | None | -14 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 484 | 16 | 2 | 6 | 3.5 | CC(=O)NCCN(C)c1cccc(OCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 | 10.1016/j.bmc.2011.06.063 | |||
CHEMBL1813320 | 71223 | 0 | None | -14 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 484 | 16 | 2 | 6 | 3.5 | CC(=O)NCCN(C)c1cccc(OCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 | 10.1016/j.bmc.2011.06.063 | |||
18522267 | 73099 | 0 | None | -5 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 377 | 11 | 1 | 2 | 5.8 | CCCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL184990 | 73099 | 0 | None | -5 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 377 | 11 | 1 | 2 | 5.8 | CCCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
10956792 | 108588 | 7 | None | 1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 277 | 5 | 2 | 4 | 1.8 | COc1ccc2[nH]cc(CCNC(C)=O)c2c1[N+](=O)[O-] | 10.1021/jm011053+ | |||
CHEMBL300195 | 108588 | 7 | None | 1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 277 | 5 | 2 | 4 | 1.8 | COc1ccc2[nH]cc(CCNC(C)=O)c2c1[N+](=O)[O-] | 10.1021/jm011053+ | |||
10022490 | 73831 | 0 | None | -22 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 377 | 10 | 1 | 2 | 5.7 | CC(C)C(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL187186 | 73831 | 0 | None | -22 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 377 | 10 | 1 | 2 | 5.7 | CC(C)C(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
44264692 | 212012 | 1 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 284 | 5 | 2 | 3 | 4.0 | COc1cccc(Nc2ccc(NC(=O)C(C)C)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
CHEMBL7874 | 212012 | 1 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 284 | 5 | 2 | 3 | 4.0 | COc1cccc(Nc2ccc(NC(=O)C(C)C)cc2)c1 | 10.1016/j.bmcl.2003.11.030 | |||
46888491 | 15443 | 0 | None | -20 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 501 | 13 | 3 | 4 | 4.9 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4[nH]cc(CCNC(C)=O)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
CHEMBL1095522 | 15443 | 0 | None | -20 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 501 | 13 | 3 | 4 | 4.9 | CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4[nH]cc(CCNC(C)=O)c4c3)cc12 | 10.1016/j.bmc.2010.04.008 | |||
44358087 | 123191 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 274 | 3 | 1 | 3 | 2.0 | CC(C)C(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
CHEMBL336024 | 123191 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 274 | 3 | 1 | 3 | 2.0 | CC(C)C(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1 | 10.1016/j.bmcl.2003.09.030 | |||
10620323 | 215119 | 0 | None | 34 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 388 | 6 | 1 | 3 | 4.7 | CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1 | 10.1021/jm980684+ | |||
CHEMBL9935 | 215119 | 0 | None | 34 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 388 | 6 | 1 | 3 | 4.7 | CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1 | 10.1021/jm980684+ | |||
11595087 | 83442 | 0 | None | 6 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 328 | 6 | 1 | 3 | 3.9 | CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1 | 10.1021/jm0512544 | |||
CHEMBL206419 | 83442 | 0 | None | 6 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 328 | 6 | 1 | 3 | 3.9 | CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1 | 10.1021/jm0512544 | |||
11277044 | 133380 | 1 | None | 6 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 263 | 2 | 1 | 1 | 3.3 | CC(=O)NCC1=Cc2ccccc2Cc2ccccc21 | 10.1021/jm040768k | |||
CHEMBL365249 | 133380 | 1 | None | 6 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 263 | 2 | 1 | 1 | 3.3 | CC(=O)NCC1=Cc2ccccc2Cc2ccccc21 | 10.1021/jm040768k | |||
45269177 | 201644 | 0 | None | 3 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 299 | 5 | 1 | 3 | 2.5 | CCCC(=O)NCCc1c2n(c3ccccc13)CCN(C)C2 | 10.1016/j.bmc.2009.04.068 | |||
CHEMBL540182 | 201644 | 0 | None | 3 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 299 | 5 | 1 | 3 | 2.5 | CCCC(=O)NCCc1c2n(c3ccccc13)CCN(C)C2 | 10.1016/j.bmc.2009.04.068 | |||
44429457 | 176130 | 0 | None | 6 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 350 | 7 | 1 | 3 | 4.3 | CCCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL441916 | 176130 | 0 | None | 6 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 350 | 7 | 1 | 3 | 4.3 | CCCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
71540390 | 93193 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 235 | 4 | 1 | 3 | 1.7 | COc1ccc(OC)c([C@@H]2C[C@H]2NC(C)=O)c1 | 10.1016/j.bmcl.2012.11.069 | |||
CHEMBL2314263 | 93193 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 235 | 4 | 1 | 3 | 1.7 | COc1ccc(OC)c([C@@H]2C[C@H]2NC(C)=O)c1 | 10.1016/j.bmcl.2012.11.069 | |||
56653479 | 117647 | 0 | None | -10 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 352 | 9 | 2 | 3 | 3.7 | CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12 | 10.1039/C5MD00190K | |||
CHEMBL3260986 | 117647 | 0 | None | -10 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 352 | 9 | 2 | 3 | 3.7 | CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12 | 10.1039/C5MD00190K | |||
56653479 | 117647 | 0 | None | -10 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 352 | 9 | 2 | 3 | 3.7 | CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12 | 10.1021/jm401343c | |||
CHEMBL3260986 | 117647 | 0 | None | -10 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 352 | 9 | 2 | 3 | 3.7 | CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12 | 10.1021/jm401343c | |||
56653479 | 117647 | 0 | None | -10 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 352 | 9 | 2 | 3 | 3.7 | CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12 | 10.1039/C5MD00190K | |||
CHEMBL3260986 | 117647 | 0 | None | -10 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 352 | 9 | 2 | 3 | 3.7 | CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12 | 10.1039/C5MD00190K | |||
44429454 | 155994 | 0 | None | 1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 336 | 7 | 2 | 2 | 4.3 | CCCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
CHEMBL394408 | 155994 | 0 | None | 1 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 336 | 7 | 2 | 2 | 4.3 | CCCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12 | 10.1016/j.bmc.2007.04.013 | |||
22718555 | 23361 | 0 | None | -2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 288 | 6 | 1 | 3 | 3.7 | CC(C)C(=O)NCCCc1cccc2nc(C(C)C)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL123973 | 23361 | 0 | None | -2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 288 | 6 | 1 | 3 | 3.7 | CC(C)C(=O)NCCCc1cccc2nc(C(C)C)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
22718530 | 24719 | 0 | None | -2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 294 | 5 | 1 | 3 | 3.6 | CC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
CHEMBL126005 | 24719 | 0 | None | -2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 294 | 5 | 1 | 3 | 3.6 | CC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12 | 10.1016/j.bmcl.2004.04.082 | |||
11219713 | 132621 | 0 | None | 4 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 279 | 3 | 1 | 1 | 3.4 | CC(=O)NCCC1Cc2ccccc2Cc2ccccc21 | 10.1021/jm040768k | |||
CHEMBL364835 | 132621 | 0 | None | 4 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 279 | 3 | 1 | 1 | 3.4 | CC(=O)NCCC1Cc2ccccc2Cc2ccccc21 | 10.1021/jm040768k | |||
45268318 | 203105 | 0 | None | 6 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 315 | 4 | 1 | 4 | 2.2 | COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCN(C)C1 | 10.1016/j.bmc.2009.04.068 | |||
CHEMBL562328 | 203105 | 0 | None | 6 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 315 | 4 | 1 | 4 | 2.2 | COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCN(C)C1 | 10.1016/j.bmc.2009.04.068 | |||
127038130 | 143401 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 347 | 8 | 1 | 2 | 4.5 | CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12 | 10.1039/C5MD00190K | |||
CHEMBL3739824 | 143401 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 347 | 8 | 1 | 2 | 4.5 | CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12 | 10.1039/C5MD00190K | |||
127038132 | 143592 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 361 | 9 | 1 | 2 | 4.9 | CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12 | 10.1039/C5MD00190K | |||
CHEMBL3741561 | 143592 | 0 | None | 1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 361 | 9 | 1 | 2 | 4.9 | CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12 | 10.1039/C5MD00190K | |||
145979282 | 173454 | 0 | None | 16 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 300 | 3 | 2 | 2 | 3.0 | CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4281915 | 173454 | 0 | None | 16 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 300 | 3 | 2 | 2 | 3.0 | CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
10428383 | 10685 | 5 | None | 151 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 356 | 6 | 1 | 3 | 4.4 | CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC | 10.1021/jm800974d | |||
7783 | 10685 | 5 | None | 151 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 356 | 6 | 1 | 3 | 4.4 | CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC | 10.1021/jm800974d | |||
CHEMBL33185 | 10685 | 5 | None | 151 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 356 | 6 | 1 | 3 | 4.4 | CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC | 10.1021/jm800974d | |||
45270052 | 202172 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 381 | 8 | 2 | 4 | 3.5 | COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1 | 10.1016/j.bmc.2009.04.068 | |||
CHEMBL552002 | 202172 | 0 | None | -1 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 381 | 8 | 2 | 4 | 3.5 | COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1 | 10.1016/j.bmc.2009.04.068 | |||
127038225 | 144766 | 0 | None | 13 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 338 | 5 | 1 | 4 | 3.8 | COc1ccc2oc(-c3c(C)cccc3C)c(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
CHEMBL3764421 | 144766 | 0 | None | 13 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 338 | 5 | 1 | 4 | 3.8 | COc1ccc2oc(-c3c(C)cccc3C)c(CCNC(C)=O)c2n1 | 10.1016/j.ejmech.2016.01.008 | |||
10853020 | 104942 | 0 | None | 15 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 318 | 4 | 1 | 2 | 3.9 | CCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2 | 10.1021/jm980684+ | |||
CHEMBL273897 | 104942 | 0 | None | 15 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 318 | 4 | 1 | 2 | 3.9 | CCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2 | 10.1021/jm980684+ | |||
90666307 | 116161 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 389 | 8 | 2 | 3 | 3.9 | C=CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12 | 10.1039/C1MD00149C | |||
CHEMBL3219328 | 116161 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 389 | 8 | 2 | 3 | 3.9 | C=CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12 | 10.1039/C1MD00149C | |||
45270052 | 202172 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 381 | 8 | 2 | 4 | 3.5 | COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1 | 10.1016/j.bmc.2009.04.068 | |||
CHEMBL552002 | 202172 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 381 | 8 | 2 | 4 | 3.5 | COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1 | 10.1016/j.bmc.2009.04.068 | |||
49865149 | 22605 | 2 | None | -2 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 223 | 5 | 1 | 3 | 1.6 | COc1cccc(OC(C)CNC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1222986 | 22605 | 2 | None | -2 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 223 | 5 | 1 | 3 | 1.6 | COc1cccc(OC(C)CNC(C)=O)c1 | 10.1016/j.bmc.2010.06.100 | |||
10959837 | 214357 | 0 | None | 4 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 379 | 10 | 1 | 3 | 5.3 | CCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
CHEMBL94919 | 214357 | 0 | None | 4 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 379 | 10 | 1 | 3 | 5.3 | CCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1 | 10.1021/jm0005252 | |||
49865270 | 22652 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 265 | 6 | 1 | 3 | 2.7 | COc1cccc(SC(C)CNC(=O)C2CC2)c1 | 10.1016/j.bmc.2010.06.100 | |||
CHEMBL1223131 | 22652 | 0 | None | -1 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 265 | 6 | 1 | 3 | 2.7 | COc1cccc(SC(C)CNC(=O)C2CC2)c1 | 10.1016/j.bmc.2010.06.100 | |||
9909783 | 73910 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 415 | 6 | 0 | 3 | 5.4 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 | 10.1021/jm048956y | |||
CHEMBL187525 | 73910 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 415 | 6 | 0 | 3 | 5.4 | COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2 | 10.1021/jm048956y | |||
44389768 | 71317 | 0 | None | -1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 426 | 9 | 2 | 2 | 5.5 | CCNC(=O)NC[C@@H]1C[C@H]1c1c(Cl)ccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
CHEMBL181457 | 71317 | 0 | None | -1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 426 | 9 | 2 | 2 | 5.5 | CCNC(=O)NC[C@@H]1C[C@H]1c1c(Cl)ccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
20590665 | 130407 | 0 | None | -14 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 391 | 9 | 1 | 2 | 5.3 | CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
CHEMBL361854 | 130407 | 0 | None | -14 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 391 | 9 | 1 | 2 | 5.3 | CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2 | 10.1016/j.bmcl.2005.01.015 | |||
11616029 | 84769 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 272 | 4 | 1 | 3 | 2.4 | COc1ccc2c(c1)c(C1(CNC(C)=O)CC1)cn2C | 10.1021/jm0512544 | |||
CHEMBL209711 | 84769 | 0 | None | 1 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 272 | 4 | 1 | 3 | 2.4 | COc1ccc2c(c1)c(C1(CNC(C)=O)CC1)cn2C | 10.1021/jm0512544 | |||
20590664 | 130450 | 0 | None | -2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 390 | 9 | 2 | 2 | 5.4 | CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL362097 | 130450 | 0 | None | -2 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 390 | 9 | 2 | 2 | 5.4 | CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2oc(CCCCc3ccccc3)cc12 | 10.1016/j.bmcl.2004.07.055 | |||
24763223 | 7004 | 0 | None | -74 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 340 | 10 | 1 | 3 | 3.7 | CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C | 10.1039/C5MD00190K | |||
8289 | 7004 | 0 | None | -74 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 340 | 10 | 1 | 3 | 3.7 | CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C | 10.1039/C5MD00190K | |||
CHEMBL3260987 | 7004 | 0 | None | -74 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 340 | 10 | 1 | 3 | 3.7 | CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C | 10.1039/C5MD00190K | |||
681 | 8247 | 72 | None | -42 | 38 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1016/S0960-894X(97)00444-7 | |||
940 | 8247 | 72 | None | -42 | 38 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1016/S0960-894X(97)00444-7 | |||
947 | 8247 | 72 | None | -42 | 38 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1016/S0960-894X(97)00444-7 | |||
CHEMBL59 | 8247 | 72 | None | -42 | 38 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1016/S0960-894X(97)00444-7 | |||
DB00988 | 8247 | 72 | None | -42 | 38 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | 10.1016/S0960-894X(97)00444-7 | |||
54586061 | 67533 | 0 | None | 1 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 3.2 | COc1ccc2c(CN3CCN(c4cccc(Cl)c4)CC3)cn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | |||
CHEMBL1760952 | 67533 | 0 | None | 1 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 441 | 7 | 1 | 6 | 3.2 | COc1ccc2c(CN3CCN(c4cccc(Cl)c4)CC3)cn(CCNC(C)=O)c2n1 | 10.1016/j.bmcl.2011.02.097 | |||
56671856 | 71225 | 0 | None | -4 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 526 | 19 | 2 | 6 | 4.6 | CC(=O)NCCN(C)c1cccc(OCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 | 10.1016/j.bmc.2011.06.063 | |||
CHEMBL1813322 | 71225 | 0 | None | -4 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 526 | 19 | 2 | 6 | 4.6 | CC(=O)NCCN(C)c1cccc(OCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1 | 10.1016/j.bmc.2011.06.063 | |||
10513751 | 170073 | 1 | None | -1 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1cccc2[nH]c(CCNC(C)=O)cc12 | 10.1021/jm001125h | |||
CHEMBL418789 | 170073 | 1 | None | -1 | 2 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1cccc2[nH]c(CCNC(C)=O)cc12 | 10.1021/jm001125h | |||
10513752 | 115277 | 3 | None | 1 | 2 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2[nH]c(CCNC(C)=O)cc2c1 | 10.1021/jm001125h | |||
CHEMBL319970 | 115277 | 3 | None | 1 | 2 | Human | 5.0 | pKi | = | 5.0 | Binding | ChEMBL | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2[nH]c(CCNC(C)=O)cc2c1 | 10.1021/jm001125h | |||
18522272 | 72863 | 0 | None | -15 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 375 | 10 | 1 | 2 | 5.5 | O=C(NCCCc1cccc2oc(CCCCc3ccccc3)cc12)C1CC1 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL183846 | 72863 | 0 | None | -15 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 375 | 10 | 1 | 2 | 5.5 | O=C(NCCCc1cccc2oc(CCCCc3ccccc3)cc12)C1CC1 | 10.1016/j.bmcl.2004.07.055 | |||
16743294 | 98856 | 0 | None | 1 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 256 | 4 | 1 | 2 | 2.7 | CC(=O)NCCCc1cn2c3c(cccc13)CCC2 | 10.1016/j.ejmech.2007.01.005 | |||
CHEMBL241928 | 98856 | 0 | None | 1 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 256 | 4 | 1 | 2 | 2.7 | CC(=O)NCCCc1cn2c3c(cccc13)CCC2 | 10.1016/j.ejmech.2007.01.005 | |||
CHEMBL3109562 | 217869 | 0 | None | 2 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | None | None | None | CCC1=C(C)C2=Cc3c(CCNC(C)=O)c4cc(OC)ccc4n3[B-](F)(F)[N+]2=C1C | 10.1021/ml4004155 | |||||
145982333 | 173336 | 0 | None | -1 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 284 | 3 | 2 | 2 | 2.8 | CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
CHEMBL4279639 | 173336 | 0 | None | -1 | 3 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 284 | 3 | 2 | 2 | 2.8 | CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21 | 10.1016/j.ejmech.2017.10.025 | |||
44394338 | 128821 | 0 | None | -2 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 405 | 8 | 2 | 3 | 4.9 | CCNC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 | 10.1016/j.bmcl.2004.07.055 | |||
CHEMBL359561 | 128821 | 0 | None | -2 | 2 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 405 | 8 | 2 | 3 | 4.9 | CCNC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1 | 10.1016/j.bmcl.2004.07.055 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10696085 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10696085 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10696085 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10696085 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10696085 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.3 | pKd | = | 9.3 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 10696085 | |||
1358 | 6912 | 41 | 125I-Iodomelatonin | 870 | 2 | Human | 11.0 | pKi | = | 11 | Binding | PDSP KiDatabase | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | None | |||
3976006 | 6912 | 41 | 125I-Iodomelatonin | 870 | 2 | Human | 11.0 | pKi | = | 11 | Binding | PDSP KiDatabase | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | None | |||
CHEMBL285718 | 6912 | 41 | 125I-Iodomelatonin | 870 | 2 | Human | 11.0 | pKi | = | 11 | Binding | PDSP KiDatabase | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | None | |||
198 | 7101 | 126 | 125I-Iodomelatonin | 1 | 6 | Human | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
82148 | 7101 | 126 | 125I-Iodomelatonin | 1 | 6 | Human | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
99 | 7101 | 126 | 125I-Iodomelatonin | 1 | 6 | Human | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
CHEMBL10878 | 7101 | 126 | 125I-Iodomelatonin | 1 | 6 | Human | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
DB06594 | 7101 | 126 | 125I-Iodomelatonin | 1 | 6 | Human | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
1357 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 10.5 | pKi | = | 10.5 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1357 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 10.3 | pKi | = | 10.3 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 10.3 | pKi | = | 10.3 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 10.3 | pKi | = | 10.3 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 10.3 | pKi | = | 10.3 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 10.3 | pKi | = | 10.3 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 10.3 | pKi | = | 10.3 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
198 | 7101 | 126 | 125I-Iodomelatonin | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
82148 | 7101 | 126 | 125I-Iodomelatonin | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
99 | 7101 | 126 | 125I-Iodomelatonin | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
CHEMBL10878 | 7101 | 126 | 125I-Iodomelatonin | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
DB06594 | 7101 | 126 | 125I-Iodomelatonin | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
1357 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 10.0 | pKi | = | 10.0 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 10.0 | pKi | = | 10.0 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 10.0 | pKi | = | 10.0 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 10.0 | pKi | = | 10.0 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 10.0 | pKi | = | 10.0 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 10.0 | pKi | = | 10.0 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1357 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.9 | pKi | = | 9.9 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1357 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1349 | 8630 | 0 | 125I-Iodomelatonin | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 246 | 3 | 1 | 3 | 1.1 | CC(=O)NCCN1CCc2c1c1CCOc1cc2 | None | |||
5311134 | 8630 | 0 | 125I-Iodomelatonin | 1 | 2 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 246 | 3 | 1 | 3 | 1.1 | CC(=O)NCCN1CCc2c1c1CCOc1cc2 | None | |||
1357 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1357 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.8 | pKi | = | 9.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1357 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1357 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1357 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1357 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.7 | pKi | = | 9.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
198 | 7101 | 126 | 125I-Mel | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
82148 | 7101 | 126 | 125I-Mel | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
99 | 7101 | 126 | 125I-Mel | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
CHEMBL10878 | 7101 | 126 | 125I-Mel | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
DB06594 | 7101 | 126 | 125I-Mel | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
1357 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1357 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1357 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1357 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
198 | 7101 | 126 | UNDEFINED | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
82148 | 7101 | 126 | UNDEFINED | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
99 | 7101 | 126 | UNDEFINED | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
CHEMBL10878 | 7101 | 126 | UNDEFINED | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
DB06594 | 7101 | 126 | UNDEFINED | 1 | 6 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
1354 | 10209 | 15 | UNDEFINED | 275 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 334 | 5 | 2 | 3 | 3.8 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N | None | |||
22133318 | 10209 | 15 | UNDEFINED | 275 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 334 | 5 | 2 | 3 | 3.8 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N | None | |||
CHEMBL490188 | 10209 | 15 | UNDEFINED | 275 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 334 | 5 | 2 | 3 | 3.8 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N | None | |||
12985495 | 188165 | 0 | UNDEFINED | 213 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 377 | 8 | 2 | 3 | 4.5 | CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 | None | |||
CHEMBL476341 | 188165 | 0 | UNDEFINED | 213 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | PDSP KiDatabase | 377 | 8 | 2 | 3 | 4.5 | CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 | None | |||
1357 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.5 | pKi | = | 9.5 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
7922 | 8737 | 0 | UNDEFINED | 741 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO | None | |||
9798456 | 8737 | 0 | UNDEFINED | 741 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO | None | |||
CHEMBL476131 | 8737 | 0 | UNDEFINED | 741 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO | None | |||
9818487 | 180312 | 0 | UNDEFINED | 141 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 319 | 5 | 1 | 2 | 4.2 | COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1 | None | |||
CHEMBL453138 | 180312 | 0 | UNDEFINED | 141 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 319 | 5 | 1 | 2 | 4.2 | COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1 | None | |||
1357 | 9263 | 139 | UNDEFINED | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | UNDEFINED | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | UNDEFINED | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | UNDEFINED | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | UNDEFINED | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | UNDEFINED | 1 | 9 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
44579259 | 193893 | 0 | UNDEFINED | 331 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 347 | 6 | 1 | 3 | 4.0 | COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1 | None | |||
CHEMBL491604 | 193893 | 0 | UNDEFINED | 331 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | PDSP KiDatabase | 347 | 6 | 1 | 3 | 4.0 | COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1 | None | |||
1349 | 8630 | 0 | 125I-Iodomelatonin | 1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 246 | 3 | 1 | 3 | 1.1 | CC(=O)NCCN1CCc2c1c1CCOc1cc2 | None | |||
5311134 | 8630 | 0 | 125I-Iodomelatonin | 1 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 246 | 3 | 1 | 3 | 1.1 | CC(=O)NCCN1CCc2c1c1CCOc1cc2 | None | |||
1357 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
44579115 | 188614 | 0 | UNDEFINED | 162 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 348 | 6 | 2 | 3 | 4.2 | CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 | None | |||
CHEMBL477835 | 188614 | 0 | UNDEFINED | 162 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 348 | 6 | 2 | 3 | 4.2 | CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 | None | |||
12985494 | 197408 | 0 | UNDEFINED | 239 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 363 | 7 | 2 | 3 | 4.1 | CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 | None | |||
CHEMBL518113 | 197408 | 0 | UNDEFINED | 239 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 363 | 7 | 2 | 3 | 4.1 | CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12 | None | |||
12985491 | 193759 | 0 | UNDEFINED | 91 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 411 | 6 | 1 | 2 | 5.1 | COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1 | None | |||
CHEMBL490595 | 193759 | 0 | UNDEFINED | 91 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | PDSP KiDatabase | 411 | 6 | 1 | 2 | 5.1 | COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1 | None | |||
44579260 | 193894 | 0 | UNDEFINED | 38 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 377 | 6 | 1 | 4 | 4.0 | COC(=O)c1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 | None | |||
CHEMBL491605 | 193894 | 0 | UNDEFINED | 38 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 377 | 6 | 1 | 4 | 4.0 | COC(=O)c1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 | None | |||
1357 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
12985492 | 188610 | 0 | UNDEFINED | 177 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 459 | 6 | 1 | 2 | 5.1 | COc1ccc2cc(-c3cccc(CI)c3)cc(CCNC(C)=O)c2c1 | None | |||
CHEMBL477833 | 188610 | 0 | UNDEFINED | 177 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | PDSP KiDatabase | 459 | 6 | 1 | 2 | 5.1 | COc1ccc2cc(-c3cccc(CI)c3)cc(CCNC(C)=O)c2c1 | None | |||
44579163 | 188908 | 0 | UNDEFINED | 53 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 362 | 6 | 1 | 3 | 4.3 | COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1 | None | |||
CHEMBL478217 | 188908 | 0 | UNDEFINED | 53 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 362 | 6 | 1 | 3 | 4.3 | COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1 | None | |||
12985493 | 193871 | 0 | UNDEFINED | 213 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 363 | 7 | 1 | 3 | 4.3 | COCc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 | None | |||
CHEMBL491403 | 193871 | 0 | UNDEFINED | 213 | 2 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 363 | 7 | 1 | 3 | 4.3 | COCc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 | None | |||
1357 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Mel | 1 | 9 | Human | 9.0 | pKi | = | 9.0 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1358 | 6912 | 41 | 125I-Iodomelatonin | 870 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | None | |||
3976006 | 6912 | 41 | 125I-Iodomelatonin | 870 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | None | |||
CHEMBL285718 | 6912 | 41 | 125I-Iodomelatonin | 870 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | None | |||
1357 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
12985489 | 197015 | 0 | UNDEFINED | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2cc(-c3ccccc3CO)cc(CCNC(C)=O)c2c1 | None | |||
CHEMBL517502 | 197015 | 0 | UNDEFINED | 3 | 2 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2cc(-c3ccccc3CO)cc(CCNC(C)=O)c2c1 | None | |||
198 | 7101 | 126 | None | 1 | 6 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
82148 | 7101 | 126 | None | 1 | 6 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
99 | 7101 | 126 | None | 1 | 6 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
CHEMBL10878 | 7101 | 126 | None | 1 | 6 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
DB06594 | 7101 | 126 | None | 1 | 6 | Human | 8.0 | pKi | = | 8 | Binding | Drug Central | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | None | |||
122162 | 9166 | 75 | 125I-Iodomelatonin | 18 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | None | |||
1363 | 9166 | 75 | 125I-Iodomelatonin | 18 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | None | |||
CHEMBL286615 | 9166 | 75 | 125I-Iodomelatonin | 18 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | None | |||
1356 | 10061 | 99 | None | -3 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | None | |||
208902 | 10061 | 99 | None | -3 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | None | |||
2355 | 10061 | 99 | None | -3 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | None | |||
CHEMBL1218 | 10061 | 99 | None | -3 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | None | |||
DB00980 | 10061 | 99 | None | -3 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | None | |||
5 | 6927 | 72 | 125I-Mel | -23442 | 53 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
5202 | 6927 | 72 | 125I-Mel | -23442 | 53 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
CHEMBL39 | 6927 | 72 | 125I-Mel | -23442 | 53 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
DB08839 | 6927 | 72 | 125I-Mel | -23442 | 53 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
107 | 6929 | 121 | 125I-Iodomelatonin | -14791 | 31 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
1833 | 6929 | 121 | 125I-Iodomelatonin | -14791 | 31 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
CHEMBL8165 | 6929 | 121 | 125I-Iodomelatonin | -14791 | 31 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
4209 | 9937 | 75 | 125I-Mel | -26915 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | |||
4893 | 9937 | 75 | 125I-Mel | -26915 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | |||
503 | 9937 | 75 | 125I-Mel | -26915 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | |||
5385 | 9937 | 75 | 125I-Mel | -26915 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | |||
CHEMBL2 | 9937 | 75 | 125I-Mel | -26915 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | |||
DB00457 | 9937 | 75 | 125I-Mel | -26915 | 33 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 383 | 4 | 1 | 8 | 1.8 | COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1 | None | |||
122162 | 9166 | 75 | 125I-Iodomelatonin | 18 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | None | |||
1363 | 9166 | 75 | 125I-Iodomelatonin | 18 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | None | |||
CHEMBL286615 | 9166 | 75 | 125I-Iodomelatonin | 18 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | PDSP KiDatabase | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | None | |||
70547 | 120120 | 79 | 125I-Iodomelatonin | 10 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 202 | 3 | 2 | 1 | 1.8 | CC(=O)NCCc1c[nH]c2ccccc12 | None | |||
CHEMBL33171 | 120120 | 79 | 125I-Iodomelatonin | 10 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 202 | 3 | 2 | 1 | 1.8 | CC(=O)NCCc1c[nH]c2ccccc12 | None | |||
122162 | 9166 | 75 | 125I-Iodomelatonin | 18 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | None | |||
1363 | 9166 | 75 | 125I-Iodomelatonin | 18 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | None | |||
CHEMBL286615 | 9166 | 75 | 125I-Iodomelatonin | 18 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | PDSP KiDatabase | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | None | |||
903 | 119678 | 89 | 125I-Iodomelatonin | -1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 218 | 3 | 3 | 2 | 1.6 | CC(=O)NCCc1c[nH]c2ccc(O)cc12 | None | |||
CHEMBL33103 | 119678 | 89 | 125I-Iodomelatonin | -1 | 2 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 218 | 3 | 3 | 2 | 1.6 | CC(=O)NCCc1c[nH]c2ccc(O)cc12 | None | |||
903 | 119678 | 89 | 125I-Iodomelatonin | -1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 218 | 3 | 3 | 2 | 1.6 | CC(=O)NCCc1c[nH]c2ccc(O)cc12 | None | |||
CHEMBL33103 | 119678 | 89 | 125I-Iodomelatonin | -1 | 2 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 218 | 3 | 3 | 2 | 1.6 | CC(=O)NCCc1c[nH]c2ccc(O)cc12 | None | |||
1357 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 8.7 | pKi | = | 8.7 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
12985490 | 187999 | 0 | UNDEFINED | 12 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2cc(-c3ccc(CO)cc3)cc(CCNC(C)=O)c2c1 | None | |||
CHEMBL476132 | 187999 | 0 | UNDEFINED | 12 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2cc(-c3ccc(CO)cc3)cc(CCNC(C)=O)c2c1 | None | |||
122162 | 9166 | 75 | 125I-Iodomelatonin | 18 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | None | |||
1363 | 9166 | 75 | 125I-Iodomelatonin | 18 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | None | |||
CHEMBL286615 | 9166 | 75 | 125I-Iodomelatonin | 18 | 2 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | None | |||
10427851 | 188612 | 0 | UNDEFINED | 407 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 348 | 6 | 2 | 3 | 3.7 | COc1ccc2cc(-c3cccc(CN)c3)cc(CCNC(C)=O)c2c1 | None | |||
CHEMBL477834 | 188612 | 0 | UNDEFINED | 407 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 348 | 6 | 2 | 3 | 3.7 | COc1ccc2cc(-c3cccc(CN)c3)cc(CCNC(C)=O)c2c1 | None | |||
164157684 | 222881 | 0 | 125I-Iodomelatonin | 60 | 2 | Human | 8.5 | pKi | = | 8.5 | Binding | PDSP KiDatabase | 1094 | 24 | 4 | 18 | 8.7 | CC(C)(C)OC(=O)N(C)CC(CN(C)C(=O)OC(C)(C)C)CSP(=O)(O)O.CNCC(CNC)CSP(=O)(OCOC(=O)C1=CC=CC=C1)OCOC(=O)C2=CC=CC=C2.C1=CC=C(C=C1)C(=O)OCCl | None | |||
903 | 119678 | 89 | 125I-Iodomelatonin | -1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 218 | 3 | 3 | 2 | 1.6 | CC(=O)NCCc1c[nH]c2ccc(O)cc12 | None | |||
CHEMBL33103 | 119678 | 89 | 125I-Iodomelatonin | -1 | 2 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 218 | 3 | 3 | 2 | 1.6 | CC(=O)NCCc1c[nH]c2ccc(O)cc12 | None | |||
44579261 | 193758 | 0 | UNDEFINED | 87 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 363 | 6 | 2 | 3 | 3.9 | COc1ccc2cc(-c3cccc(C(=O)O)c3)cc(CCNC(C)=O)c2c1 | None | |||
CHEMBL490594 | 193758 | 0 | UNDEFINED | 87 | 2 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 363 | 6 | 2 | 3 | 3.9 | COc1ccc2cc(-c3cccc(C(=O)O)c3)cc(CCNC(C)=O)c2c1 | None | |||
12985496 | 189110 | 0 | UNDEFINED | 31 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 389 | 7 | 2 | 3 | 4.5 | COc1ccc2cc(-c3cccc(CO)c3)cc(CCNC(=O)C3CCC3)c2c1 | None | |||
CHEMBL478438 | 189110 | 0 | UNDEFINED | 31 | 2 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 389 | 7 | 2 | 3 | 4.5 | COc1ccc2cc(-c3cccc(CO)c3)cc(CCNC(=O)C3CCC3)c2c1 | None | |||
681 | 8247 | 72 | None | -42 | 38 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
940 | 8247 | 72 | None | -42 | 38 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
947 | 8247 | 72 | None | -42 | 38 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
CHEMBL59 | 8247 | 72 | None | -42 | 38 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
DB00988 | 8247 | 72 | None | -42 | 38 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 153 | 2 | 3 | 3 | 0.6 | NCCc1ccc(c(c1)O)O | None | |||
1357 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
1672 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
224 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
896 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
CHEMBL45 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
DB01065 | 9263 | 139 | 125I-Iodomelatonin | 1 | 9 | Human | 8.3 | pKi | = | 8.3 | Binding | PDSP KiDatabase | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | None | |||
None | 222878 | 0 | 125I-Mel | 1 | 2 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 218 | 2 | 2 | 4 | 1.5 | CC(=O)N1C=C(C2=C1C=CC(=C2)O)CCN | None | |||
70547 | 120120 | 79 | 125I-Iodomelatonin | 10 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 202 | 3 | 2 | 1 | 1.8 | CC(=O)NCCc1c[nH]c2ccccc12 | None | |||
CHEMBL33171 | 120120 | 79 | 125I-Iodomelatonin | 10 | 2 | Human | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 202 | 3 | 2 | 1 | 1.8 | CC(=O)NCCc1c[nH]c2ccccc12 | None | |||
44579296 | 193573 | 0 | UNDEFINED | 5 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 376 | 6 | 2 | 3 | 4.2 | COc1ccc2cc(-c3cccc(NC(C)=O)c3)cc(CCNC(C)=O)c2c1 | None | |||
CHEMBL489170 | 193573 | 0 | UNDEFINED | 5 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 376 | 6 | 2 | 3 | 4.2 | COc1ccc2cc(-c3cccc(NC(C)=O)c3)cc(CCNC(C)=O)c2c1 | None | |||
12835 | 222882 | 0 | 125I-Iodomelatonin | 6 | 2 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 191 | 3 | 2 | 2 | 1.7 | COC1=CC2=C(C=C1)NC=C2CCO | None | |||
44579164 | 188909 | 0 | UNDEFINED | 14 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 406 | 7 | 2 | 4 | 4.8 | CCOC(=O)Nc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 | None | |||
CHEMBL478218 | 188909 | 0 | UNDEFINED | 14 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | PDSP KiDatabase | 406 | 7 | 2 | 4 | 4.8 | CCOC(=O)Nc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1 | None | |||
10220503 | 10528 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 245 | 4 | 1 | 2 | 2.3 | CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 | None | |||
4820 | 10528 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 245 | 4 | 1 | 2 | 2.3 | CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 | None | |||
7393 | 10528 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 245 | 4 | 1 | 2 | 2.3 | CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 | None | |||
CHEMBL2103822 | 10528 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 245 | 4 | 1 | 2 | 2.3 | CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 | None | |||
DB09071 | 10528 | 0 | None | 2 | 2 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 245 | 4 | 1 | 2 | 2.3 | CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 | None | |||
70547 | 120120 | 79 | 125I-Iodomelatonin | 10 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 202 | 3 | 2 | 1 | 1.8 | CC(=O)NCCc1c[nH]c2ccccc12 | None | |||
CHEMBL33171 | 120120 | 79 | 125I-Iodomelatonin | 10 | 2 | Human | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 202 | 3 | 2 | 1 | 1.8 | CC(=O)NCCc1c[nH]c2ccccc12 | None | |||
11196 | 8767 | 0 | None | 3 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | Guide to Pharmacology | 888 | 18 | 3 | 11 | 5.9 | COc1ccc2c(n1)c(CCNC(=O)C)cn2CCNC(=O)CCCCCN1c2ccc(cc2C(/C/1=C\C=C\C1=[N+](CC)c2c(C1(C)C)cc(cc2)S(=O)(=O)O)(C)C)S(=O)(=O)[O-] | 28493341 | |||
154699456 | 8767 | 0 | None | 3 | 2 | Human | 5.5 | pKi | = | 5.5 | Binding | Guide to Pharmacology | 888 | 18 | 3 | 11 | 5.9 | COc1ccc2c(n1)c(CCNC(=O)C)cn2CCNC(=O)CCCCCN1c2ccc(cc2C(/C/1=C\C=C\C1=[N+](CC)c2c(C1(C)C)cc(cc2)S(=O)(=O)O)(C)C)S(=O)(=O)[O-] | 28493341 | |||
115348 | 6858 | 47 | None | -4 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 12764576 | |||
115348 | 6858 | 47 | None | -4 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 2991499 | |||
115348 | 6858 | 47 | None | -4 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 9089668 | |||
115348 | 6858 | 47 | None | -4 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 9618428 | |||
1343 | 6858 | 47 | None | -4 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 12764576 | |||
1343 | 6858 | 47 | None | -4 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 2991499 | |||
1343 | 6858 | 47 | None | -4 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 9089668 | |||
1343 | 6858 | 47 | None | -4 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 9618428 | |||
CHEMBL289233 | 6858 | 47 | None | -4 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 12764576 | |||
CHEMBL289233 | 6858 | 47 | None | -4 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 2991499 | |||
CHEMBL289233 | 6858 | 47 | None | -4 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 9089668 | |||
CHEMBL289233 | 6858 | 47 | None | -4 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 9618428 | |||
DB08190 | 6858 | 47 | None | -4 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 12764576 | |||
DB08190 | 6858 | 47 | None | -4 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 2991499 | |||
DB08190 | 6858 | 47 | None | -4 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 9089668 | |||
DB08190 | 6858 | 47 | None | -4 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 358 | 4 | 2 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I | 9618428 | |||
1356 | 10061 | 99 | None | -3 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 15695169 | |||
1356 | 10061 | 99 | None | -3 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 21182402 | |||
208902 | 10061 | 99 | None | -3 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 15695169 | |||
208902 | 10061 | 99 | None | -3 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 21182402 | |||
2355 | 10061 | 99 | None | -3 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 15695169 | |||
2355 | 10061 | 99 | None | -3 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 21182402 | |||
CHEMBL1218 | 10061 | 99 | None | -3 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 15695169 | |||
CHEMBL1218 | 10061 | 99 | None | -3 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 21182402 | |||
DB00980 | 10061 | 99 | None | -3 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 15695169 | |||
DB00980 | 10061 | 99 | None | -3 | 2 | Human | 10.0 | pKi | = | 10 | Binding | Guide to Pharmacology | 259 | 4 | 1 | 2 | 2.6 | CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2 | 21182402 | |||
198 | 7101 | 126 | None | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 12764576 | |||
198 | 7101 | 126 | None | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 9618428 | |||
82148 | 7101 | 126 | None | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 12764576 | |||
82148 | 7101 | 126 | None | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 9618428 | |||
99 | 7101 | 126 | None | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 12764576 | |||
99 | 7101 | 126 | None | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 9618428 | |||
CHEMBL10878 | 7101 | 126 | None | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 12764576 | |||
CHEMBL10878 | 7101 | 126 | None | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 9618428 | |||
DB06594 | 7101 | 126 | None | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 12764576 | |||
DB06594 | 7101 | 126 | None | 1 | 6 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 243 | 4 | 1 | 2 | 2.5 | COc1ccc2c(c1)c(CCNC(=O)C)ccc2 | 9618428 | |||
10220503 | 10528 | 0 | None | 2 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 245 | 4 | 1 | 2 | 2.3 | CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 | 19054552 | |||
4820 | 10528 | 0 | None | 2 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 245 | 4 | 1 | 2 | 2.3 | CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 | 19054552 | |||
7393 | 10528 | 0 | None | 2 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 245 | 4 | 1 | 2 | 2.3 | CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 | 19054552 | |||
CHEMBL2103822 | 10528 | 0 | None | 2 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 245 | 4 | 1 | 2 | 2.3 | CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 | 19054552 | |||
DB09071 | 10528 | 0 | None | 2 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 245 | 4 | 1 | 2 | 2.3 | CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2 | 19054552 | |||
24749950 | 10688 | 8 | None | 588 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 284 | 6 | 1 | 3 | 3.0 | COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C | 18052314 | |||
7923 | 10688 | 8 | None | 588 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 284 | 6 | 1 | 3 | 3.0 | COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C | 18052314 | |||
CHEMBL394676 | 10688 | 8 | None | 588 | 2 | Human | 10.2 | pKi | = | 10.2 | Binding | Guide to Pharmacology | 284 | 6 | 1 | 3 | 3.0 | COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C | 18052314 | |||
1350 | 8771 | 0 | None | 1 | 3 | Human | 10.3 | pKi | = | 10.3 | Binding | Guide to Pharmacology | 348 | 6 | 1 | 3 | 4.1 | CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 | 10420436 | |||
1350 | 8771 | 0 | None | 1 | 3 | Human | 10.3 | pKi | = | 10.3 | Binding | Guide to Pharmacology | 348 | 6 | 1 | 3 | 4.1 | CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 | 10737738 | |||
1350 | 8771 | 0 | None | -1 | 3 | Mouse | 10.3 | pKi | = | 10.3 | Binding | Guide to Pharmacology | 348 | 6 | 1 | 3 | 4.1 | CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 | 24106342 | |||
4172142 | 8771 | 0 | None | 1 | 3 | Human | 10.3 | pKi | = | 10.3 | Binding | Guide to Pharmacology | 348 | 6 | 1 | 3 | 4.1 | CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 | 10420436 | |||
4172142 | 8771 | 0 | None | 1 | 3 | Human | 10.3 | pKi | = | 10.3 | Binding | Guide to Pharmacology | 348 | 6 | 1 | 3 | 4.1 | CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 | 10737738 | |||
4172142 | 8771 | 0 | None | -1 | 3 | Mouse | 10.3 | pKi | = | 10.3 | Binding | Guide to Pharmacology | 348 | 6 | 1 | 3 | 4.1 | CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 | 24106342 | |||
CHEMBL10009 | 8771 | 0 | None | 1 | 3 | Human | 10.3 | pKi | = | 10.3 | Binding | Guide to Pharmacology | 348 | 6 | 1 | 3 | 4.1 | CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 | 10420436 | |||
CHEMBL10009 | 8771 | 0 | None | 1 | 3 | Human | 10.3 | pKi | = | 10.3 | Binding | Guide to Pharmacology | 348 | 6 | 1 | 3 | 4.1 | CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 | 10737738 | |||
CHEMBL10009 | 8771 | 0 | None | -1 | 3 | Mouse | 10.3 | pKi | = | 10.3 | Binding | Guide to Pharmacology | 348 | 6 | 1 | 3 | 4.1 | CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2 | 24106342 | |||
53238181 | 7721 | 0 | None | 741 | 2 | Human | 10.9 | pKi | = | 10.9 | Binding | Guide to Pharmacology | 339 | 5 | 1 | 2 | 4.4 | CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2 | 21473625 | |||
7780 | 7721 | 0 | None | 741 | 2 | Human | 10.9 | pKi | = | 10.9 | Binding | Guide to Pharmacology | 339 | 5 | 1 | 2 | 4.4 | CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2 | 21473625 | |||
CHEMBL1774519 | 7721 | 0 | None | 741 | 2 | Human | 10.9 | pKi | = | 10.9 | Binding | Guide to Pharmacology | 339 | 5 | 1 | 2 | 4.4 | CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2 | 21473625 | |||
57381997 | 8867 | 0 | None | - | 1 | Human | 11.0 | pKi | = | 11 | Binding | Guide to Pharmacology | 313 | 7 | 1 | 2 | 4.1 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)CCC(C)C | 22301214 | |||
7781 | 8867 | 0 | None | - | 1 | Human | 11.0 | pKi | = | 11 | Binding | Guide to Pharmacology | 313 | 7 | 1 | 2 | 4.1 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)CCC(C)C | 22301214 | |||
CHEMBL1946226 | 8867 | 0 | None | - | 1 | Human | 11.0 | pKi | = | 11 | Binding | Guide to Pharmacology | 313 | 7 | 1 | 2 | 4.1 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)CCC(C)C | 22301214 | |||
121231413 | 10681 | 1 | None | 16982 | 2 | Human | 12.0 | pKi | = | 12 | Binding | Guide to Pharmacology | 338 | 6 | 1 | 3 | 3.5 | CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC | 26334942 | |||
9226 | 10681 | 1 | None | 16982 | 2 | Human | 12.0 | pKi | = | 12 | Binding | Guide to Pharmacology | 338 | 6 | 1 | 3 | 3.5 | CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC | 26334942 | |||
CHEMBL3612464 | 10681 | 1 | None | 16982 | 2 | Human | 12.0 | pKi | = | 12 | Binding | Guide to Pharmacology | 338 | 6 | 1 | 3 | 3.5 | CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC | 26334942 | |||
122162 | 9166 | 75 | None | 18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 10696085 | |||
122162 | 9166 | 75 | None | 18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 12764576 | |||
122162 | 9166 | 75 | None | 18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 2843633 | |||
122162 | 9166 | 75 | None | 18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 9089668 | |||
122162 | 9166 | 75 | None | 18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 9737724 | |||
1363 | 9166 | 75 | None | 18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 10696085 | |||
1363 | 9166 | 75 | None | 18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 12764576 | |||
1363 | 9166 | 75 | None | 18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 2843633 | |||
1363 | 9166 | 75 | None | 18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 9089668 | |||
1363 | 9166 | 75 | None | 18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 9737724 | |||
CHEMBL286615 | 9166 | 75 | None | 18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 10696085 | |||
CHEMBL286615 | 9166 | 75 | None | 18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 12764576 | |||
CHEMBL286615 | 9166 | 75 | None | 18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 2843633 | |||
CHEMBL286615 | 9166 | 75 | None | 18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 9089668 | |||
CHEMBL286615 | 9166 | 75 | None | 18 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | Guide to Pharmacology | 292 | 5 | 2 | 1 | 3.4 | CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 9737724 | |||
3366 | 8192 | 40 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | Guide to Pharmacology | 334 | 8 | 2 | 1 | 4.6 | CCCCC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 9840420 | |||
3467177 | 8192 | 40 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | Guide to Pharmacology | 334 | 8 | 2 | 1 | 4.6 | CCCCC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 9840420 | |||
CHEMBL1327247 | 8192 | 40 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | Guide to Pharmacology | 334 | 8 | 2 | 1 | 4.6 | CCCCC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2 | 9840420 | |||
7773 | 10687 | 0 | None | 12 | 2 | Human | 8.0 | pKi | = | 8 | Binding | Guide to Pharmacology | 296 | 3 | 2 | 2 | 2.6 | COc1ccc2c(c1)C(CNC(=O)N)Cc1c(C2)cccc1 | 15293992 | |||
86277838 | 10687 | 0 | None | 12 | 2 | Human | 8.0 | pKi | = | 8 | Binding | Guide to Pharmacology | 296 | 3 | 2 | 2 | 2.6 | COc1ccc2c(c1)C(CNC(=O)N)Cc1c(C2)cccc1 | 15293992 | |||
10428383 | 10685 | 5 | None | 151 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 356 | 6 | 1 | 3 | 4.4 | CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC | 15943478 | |||
7783 | 10685 | 5 | None | 151 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 356 | 6 | 1 | 3 | 4.4 | CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC | 15943478 | |||
CHEMBL33185 | 10685 | 5 | None | 151 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | Guide to Pharmacology | 356 | 6 | 1 | 3 | 4.4 | CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC | 15943478 | |||
1347 | 6950 | 56 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 248 | 4 | 3 | 3 | 1.6 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1O | 10696085 | |||
1347 | 6950 | 56 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 248 | 4 | 3 | 3 | 1.6 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1O | 2991499 | |||
1347 | 6950 | 56 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 248 | 4 | 3 | 3 | 1.6 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1O | 9089668 | |||
1864 | 6950 | 56 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 248 | 4 | 3 | 3 | 1.6 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1O | 10696085 | |||
1864 | 6950 | 56 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 248 | 4 | 3 | 3 | 1.6 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1O | 2991499 | |||
1864 | 6950 | 56 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 248 | 4 | 3 | 3 | 1.6 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1O | 9089668 | |||
CHEMBL127421 | 6950 | 56 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 248 | 4 | 3 | 3 | 1.6 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1O | 10696085 | |||
CHEMBL127421 | 6950 | 56 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 248 | 4 | 3 | 3 | 1.6 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1O | 2991499 | |||
CHEMBL127421 | 6950 | 56 | None | 1 | 2 | Human | 8.6 | pKi | = | 8.6 | Binding | Guide to Pharmacology | 248 | 4 | 3 | 3 | 1.6 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1O | 9089668 | |||
12324 | 10683 | 0 | None | -2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 591 | 13 | 3 | 4 | 7.0 | O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1 | 30126274 | |||
145966622 | 10683 | 0 | None | -2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 591 | 13 | 3 | 4 | 7.0 | O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1 | 30126274 | |||
CHEMBL4210086 | 10683 | 0 | None | -2 | 2 | Human | 8.8 | pKi | = | 8.8 | Binding | Guide to Pharmacology | 591 | 13 | 3 | 4 | 7.0 | O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1 | 30126274 | |||
25210130 | 6857 | 0 | None | 91 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 363 | 6 | 2 | 3 | 3.4 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2 | 19193160 | |||
7782 | 6857 | 0 | None | 91 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 363 | 6 | 2 | 3 | 3.4 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2 | 19193160 | |||
CHEMBL514415 | 6857 | 0 | None | 91 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 363 | 6 | 2 | 3 | 3.4 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2 | 19193160 | |||
11185529 | 10686 | 5 | None | 14 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 295 | 3 | 1 | 2 | 3.1 | COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 | 15293992 | |||
11185529 | 10686 | 5 | None | 14 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 295 | 3 | 1 | 2 | 3.1 | COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 | 17907131 | |||
7772 | 10686 | 5 | None | 14 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 295 | 3 | 1 | 2 | 3.1 | COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 | 15293992 | |||
7772 | 10686 | 5 | None | 14 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 295 | 3 | 1 | 2 | 3.1 | COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 | 17907131 | |||
CHEMBL189449 | 10686 | 5 | None | 14 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 295 | 3 | 1 | 2 | 3.1 | COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 | 15293992 | |||
CHEMBL189449 | 10686 | 5 | None | 14 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 295 | 3 | 1 | 2 | 3.1 | COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1 | 17907131 | |||
1358 | 6912 | 41 | None | 870 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | 12764576 | |||
1358 | 6912 | 41 | None | 870 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | 9089668 | |||
1358 | 6912 | 41 | None | 870 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | 9737724 | |||
3976006 | 6912 | 41 | None | 870 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | 12764576 | |||
3976006 | 6912 | 41 | None | 870 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | 9089668 | |||
3976006 | 6912 | 41 | None | 870 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | 9737724 | |||
CHEMBL285718 | 6912 | 41 | None | 870 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | 12764576 | |||
CHEMBL285718 | 6912 | 41 | None | 870 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | 9089668 | |||
CHEMBL285718 | 6912 | 41 | None | 870 | 2 | Human | 9.1 | pKi | = | 9.1 | Binding | Guide to Pharmacology | 279 | 3 | 1 | 1 | 3.7 | CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1 | 9737724 | |||
24750192 | 10689 | 13 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 222 | 5 | 1 | 3 | 1.3 | COc1cccc(c1)N(CCNC(=O)C)C | 18052314 | |||
7777 | 10689 | 13 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 222 | 5 | 1 | 3 | 1.3 | COc1cccc(c1)N(CCNC(=O)C)C | 18052314 | |||
CHEMBL237236 | 10689 | 13 | None | 1 | 2 | Human | 9.2 | pKi | = | 9.2 | Binding | Guide to Pharmacology | 222 | 5 | 1 | 3 | 1.3 | COc1cccc(c1)N(CCNC(=O)C)C | 18052314 | |||
1359 | 8951 | 21 | None | 125 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | 376 | 6 | 1 | 3 | 4.7 | CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 | 10420436 | |||
1359 | 8951 | 21 | None | 125 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | 376 | 6 | 1 | 3 | 4.7 | CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 | 10737738 | |||
5311198 | 8951 | 21 | None | 125 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | 376 | 6 | 1 | 3 | 4.7 | CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 | 10420436 | |||
5311198 | 8951 | 21 | None | 125 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | 376 | 6 | 1 | 3 | 4.7 | CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 | 10737738 | |||
CHEMBL274438 | 8951 | 21 | None | 125 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | 376 | 6 | 1 | 3 | 4.7 | CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 | 10420436 | |||
CHEMBL274438 | 8951 | 21 | None | 125 | 2 | Human | 9.3 | pKi | = | 9.3 | Binding | Guide to Pharmacology | 376 | 6 | 1 | 3 | 4.7 | CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2 | 10737738 | |||
24954989 | 8314 | 1 | None | -6 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 273 | 4 | 1 | 4 | 1.5 | CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2 | 21568291 | |||
7774 | 8314 | 1 | None | -6 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 273 | 4 | 1 | 4 | 1.5 | CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2 | 21568291 | |||
CHEMBL1802025 | 8314 | 1 | None | -6 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 273 | 4 | 1 | 4 | 1.5 | CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2 | 21568291 | |||
7922 | 8737 | 0 | None | 741 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO | 18778943 | |||
9798456 | 8737 | 0 | None | 741 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO | 18778943 | |||
CHEMBL476131 | 8737 | 0 | None | 741 | 2 | Human | 9.4 | pKi | = | 9.4 | Binding | Guide to Pharmacology | 349 | 6 | 2 | 3 | 3.7 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO | 18778943 | |||
71508234 | 7492 | 0 | None | 38 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | 341 | 9 | 1 | 3 | 3.8 | CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC | 23228808 | |||
7924 | 7492 | 0 | None | 38 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | 341 | 9 | 1 | 3 | 3.8 | CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC | 23228808 | |||
CHEMBL2326202 | 7492 | 0 | None | 38 | 2 | Human | 9.5 | pKi | = | 9.5 | Binding | Guide to Pharmacology | 341 | 9 | 1 | 3 | 3.8 | CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC | 23228808 | |||
1346 | 6948 | 47 | None | 25 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 266 | 4 | 2 | 2 | 2.5 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl | 12764576 | |||
1346 | 6948 | 47 | None | 25 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 266 | 4 | 2 | 2 | 2.5 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl | 2991499 | |||
1346 | 6948 | 47 | None | 25 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 266 | 4 | 2 | 2 | 2.5 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl | 9089668 | |||
1346 | 6948 | 47 | None | 25 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 266 | 4 | 2 | 2 | 2.5 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl | 9618428 | |||
1858 | 6948 | 47 | None | 25 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 266 | 4 | 2 | 2 | 2.5 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl | 12764576 | |||
1858 | 6948 | 47 | None | 25 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 266 | 4 | 2 | 2 | 2.5 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl | 2991499 | |||
1858 | 6948 | 47 | None | 25 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 266 | 4 | 2 | 2 | 2.5 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl | 9089668 | |||
1858 | 6948 | 47 | None | 25 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 266 | 4 | 2 | 2 | 2.5 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl | 9618428 | |||
CHEMBL34730 | 6948 | 47 | None | 25 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 266 | 4 | 2 | 2 | 2.5 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl | 12764576 | |||
CHEMBL34730 | 6948 | 47 | None | 25 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 266 | 4 | 2 | 2 | 2.5 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl | 2991499 | |||
CHEMBL34730 | 6948 | 47 | None | 25 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 266 | 4 | 2 | 2 | 2.5 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl | 9089668 | |||
CHEMBL34730 | 6948 | 47 | None | 25 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 266 | 4 | 2 | 2 | 2.5 | COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl | 9618428 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 12764576 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 2991499 | |||
1357 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 9089668 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 12764576 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 2991499 | |||
1672 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 9089668 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 12764576 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 2991499 | |||
224 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 9089668 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 12764576 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 2991499 | |||
896 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 9089668 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 12764576 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 2991499 | |||
CHEMBL45 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 9089668 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 12764576 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 2991499 | |||
DB01065 | 9263 | 139 | None | 1 | 9 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 232 | 4 | 2 | 2 | 1.9 | COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 9089668 | |||
129776 | 6930 | 6 | None | 128 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 322 | 6 | 2 | 2 | 3.4 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1 | 9089668 | |||
1364 | 6930 | 6 | None | 128 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 322 | 6 | 2 | 2 | 3.4 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1 | 9089668 | |||
CHEMBL339105 | 6930 | 6 | None | 128 | 2 | Human | 9.6 | pKi | = | 9.6 | Binding | Guide to Pharmacology | 322 | 6 | 2 | 2 | 3.4 | COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1 | 9089668 | |||
1351 | 9174 | 21 | None | 1 | 2 | Human | 10.4 | pKi | None | 10.4 | Binding | Guide to Pharmacology | 280 | 4 | 2 | 2 | 3.1 | COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C | 15302228 | |||
219018 | 9174 | 21 | None | 1 | 2 | Human | 10.4 | pKi | None | 10.4 | Binding | Guide to Pharmacology | 280 | 4 | 2 | 2 | 3.1 | COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C | 15302228 | |||
CHEMBL4079759 | 9174 | 21 | None | 1 | 2 | Human | 10.4 | pKi | None | 10.4 | Binding | Guide to Pharmacology | 280 | 4 | 2 | 2 | 3.1 | COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C | 15302228 | |||
1362 | 10210 | 22 | None | -39 | 2 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 498 | 12 | 2 | 4 | 5.2 | CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 12764576 | |||
9870523 | 10210 | 22 | None | -39 | 2 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 498 | 12 | 2 | 4 | 5.2 | CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 12764576 | |||
CHEMBL429392 | 10210 | 22 | None | -39 | 2 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 498 | 12 | 2 | 4 | 5.2 | CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 12764576 | |||
1355 | 10211 | 5 | None | -70 | 2 | Human | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 12764576 | |||
9806449 | 10211 | 5 | None | -70 | 2 | Human | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 12764576 | |||
CHEMBL14453 | 10211 | 5 | None | -70 | 2 | Human | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 512 | 13 | 2 | 4 | 5.6 | CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2 | 12764576 | |||
10849065 | 6925 | 8 | None | -4 | 2 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 262 | 6 | 3 | 3 | 1.2 | OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 11068946 | |||
1345 | 6925 | 8 | None | -4 | 2 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 262 | 6 | 3 | 3 | 1.2 | OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 11068946 | |||
CHEMBL126809 | 6925 | 8 | None | -4 | 2 | Human | 7.1 | pKi | None | 7.1 | Binding | Guide to Pharmacology | 262 | 6 | 3 | 3 | 1.2 | OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2 | 11068946 | |||
127856 | 10206 | 0 | None | 3 | 2 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 253 | 4 | 1 | 1 | 3.3 | O=C(C1CCC1)NCCc1cccc2c1cccc2 | 12764576 | |||
1360 | 10206 | 0 | None | 3 | 2 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 253 | 4 | 1 | 1 | 3.3 | O=C(C1CCC1)NCCc1cccc2c1cccc2 | 12764576 | |||
CHEMBL12296 | 10206 | 0 | None | 3 | 2 | Human | 7.2 | pKi | None | 7.2 | Binding | Guide to Pharmacology | 253 | 4 | 1 | 1 | 3.3 | O=C(C1CCC1)NCCc1cccc2c1cccc2 | 12764576 | |||
1361 | 10207 | 0 | None | 1 | 2 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 247 | 4 | 1 | 2 | 3.1 | CCc1ccc2c(c1)c(CCNC(=O)C)cs2 | 12764576 | |||
9816339 | 10207 | 0 | None | 1 | 2 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 247 | 4 | 1 | 2 | 3.1 | CCc1ccc2c(c1)c(CCNC(=O)C)cs2 | 12764576 | |||
1348 | 8626 | 5 | None | 100 | 2 | Human | 8.9 | pKi | None | 8.9 | Binding | Guide to Pharmacology | 272 | 2 | 1 | 2 | 2.9 | COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C | 10205014 | |||
1348 | 8626 | 5 | None | 100 | 2 | Human | 8.9 | pKi | None | 8.9 | Binding | Guide to Pharmacology | 272 | 2 | 1 | 2 | 2.9 | COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C | 9089668 | |||
44208891 | 8626 | 5 | None | 100 | 2 | Human | 8.9 | pKi | None | 8.9 | Binding | Guide to Pharmacology | 272 | 2 | 1 | 2 | 2.9 | COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C | 10205014 | |||
44208891 | 8626 | 5 | None | 100 | 2 | Human | 8.9 | pKi | None | 8.9 | Binding | Guide to Pharmacology | 272 | 2 | 1 | 2 | 2.9 | COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C | 9089668 | |||
CHEMBL3260983 | 8626 | 5 | None | 100 | 2 | Human | 8.9 | pKi | None | 8.9 | Binding | Guide to Pharmacology | 272 | 2 | 1 | 2 | 2.9 | COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C | 10205014 | |||
CHEMBL3260983 | 8626 | 5 | None | 100 | 2 | Human | 8.9 | pKi | None | 8.9 | Binding | Guide to Pharmacology | 272 | 2 | 1 | 2 | 2.9 | COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C | 9089668 | |||
1354 | 10209 | 15 | None | 275 | 2 | Human | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 334 | 5 | 2 | 3 | 3.8 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N | 12764576 | |||
22133318 | 10209 | 15 | None | 275 | 2 | Human | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 334 | 5 | 2 | 3 | 3.8 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N | 12764576 | |||
CHEMBL490188 | 10209 | 15 | None | 275 | 2 | Human | 9.5 | pKi | None | 9.5 | Binding | Guide to Pharmacology | 334 | 5 | 2 | 3 | 3.8 | COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N | 12764576 | |||
1353 | 10208 | 5 | None | 112 | 2 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 353 | 7 | 1 | 4 | 3.7 | COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC | 12764576 | |||
9998187 | 10208 | 5 | None | 112 | 2 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 353 | 7 | 1 | 4 | 3.7 | COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC | 12764576 | |||
CHEMBL33549 | 10208 | 5 | None | 112 | 2 | Human | 9.6 | pKi | None | 9.6 | Binding | Guide to Pharmacology | 353 | 7 | 1 | 4 | 3.7 | COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC | 12764576 | |||
1349 | 8630 | 0 | None | 1 | 2 | Human | 9.8 | pKi | None | 9.8 | Binding | Guide to Pharmacology | 246 | 3 | 1 | 3 | 1.1 | CC(=O)NCCN1CCc2c1c1CCOc1cc2 | 10696085 | |||
1349 | 8630 | 0 | None | 1 | 2 | Human | 9.8 | pKi | None | 9.8 | Binding | Guide to Pharmacology | 246 | 3 | 1 | 3 | 1.1 | CC(=O)NCCN1CCc2c1c1CCOc1cc2 | 9618428 | |||
5311134 | 8630 | 0 | None | 1 | 2 | Human | 9.8 | pKi | None | 9.8 | Binding | Guide to Pharmacology | 246 | 3 | 1 | 3 | 1.1 | CC(=O)NCCN1CCc2c1c1CCOc1cc2 | 10696085 | |||
5311134 | 8630 | 0 | None | 1 | 2 | Human | 9.8 | pKi | None | 9.8 | Binding | Guide to Pharmacology | 246 | 3 | 1 | 3 | 1.1 | CC(=O)NCCN1CCc2c1c1CCOc1cc2 | 9618428 |