Ligand source activities (1 row/activity)





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11656002 83012 27 None 61 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 484 3 0 3 5.8 O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm301071h
CHEMBL2181247 83012 27 None 61 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 484 3 0 3 5.8 O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm301071h
90644451 112211 0 None 3 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 459 4 0 5 6.2 Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290717 112211 0 None 3 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 459 4 0 5 6.2 Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71561754 87644 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 432 6 0 5 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C(C)C 10.1016/j.bmcl.2012.12.076
CHEMBL2336232 87644 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 432 6 0 5 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C(C)C 10.1016/j.bmcl.2012.12.076
126673452 161153 0 None 257 2 Mouse 9.5 pEC50 = 9.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 774 19 2 12 5.2 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4087611 161153 0 None 257 2 Mouse 9.5 pEC50 = 9.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 774 19 2 12 5.2 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4117342 161153 0 None 257 2 Mouse 9.5 pEC50 = 9.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 774 19 2 12 5.2 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71462787 82994 0 None 3 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.1 Cc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
CHEMBL2181229 82994 0 None 3 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.1 Cc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
155669602 181940 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 372 4 0 4 4.1 C[C@H](c1ccccc1)n1cncc1C(=O)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4779837 181940 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 372 4 0 4 4.1 C[C@H](c1ccccc1)n1cncc1C(=O)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
118577239 160983 0 None 60 2 Mouse 9.4 pEC50 = 9.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 623 13 1 9 6.0 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4060410 160983 0 None 60 2 Mouse 9.4 pEC50 = 9.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 623 13 1 9 6.0 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116055 160983 0 None 60 2 Mouse 9.4 pEC50 = 9.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 623 13 1 9 6.0 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71626699 112210 0 None 5 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 425 4 0 5 5.6 Cc1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290716 112210 0 None 5 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 425 4 0 5 5.6 Cc1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71455634 82992 0 None 4 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 473 4 0 4 6.5 O=C(c1cnccc1Oc1cc(Cl)c(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181227 82992 0 None 4 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 473 4 0 4 6.5 O=C(c1cnccc1Oc1cc(Cl)c(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
90654589 109958 0 None 1 2 Mouse 9.3 pEC50 = 9.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 543 7 1 8 2.5 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCN(C5COC5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234570 109958 0 None 1 2 Mouse 9.3 pEC50 = 9.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 543 7 1 8 2.5 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCN(C5COC5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
90654598 110006 0 None 21 2 Mouse 9.3 pEC50 = 9.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 9 2 8 4.4 COc1cc(C2CCN(c3cc(N4CC[C@H]4C(=O)NCCc4ccc(C#N)cc4)nc(C(F)(F)F)n3)CC2)ccc1C(=O)O 10.1021/jm401731q
CHEMBL3234869 110006 0 None 21 2 Mouse 9.3 pEC50 = 9.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 9 2 8 4.4 COc1cc(C2CCN(c3cc(N4CC[C@H]4C(=O)NCCc4ccc(C#N)cc4)nc(C(F)(F)F)n3)CC2)ccc1C(=O)O 10.1021/jm401731q
71462786 82993 0 None 3 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 413 4 0 4 5.4 Cc1cc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1C 10.1021/jm301071h
CHEMBL2181228 82993 0 None 3 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 413 4 0 4 5.4 Cc1cc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1C 10.1021/jm301071h
71450251 82991 28 None 8 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 4 0 4 5.1 Cc1ccc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
CHEMBL2181226 82991 28 None 8 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 4 0 4 5.1 Cc1ccc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
71461054 82996 0 None 3 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 467 5 0 4 6.4 CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
CHEMBL2181230 82996 0 None 3 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 467 5 0 4 6.4 CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
118576935 157950 0 None 43 2 Mouse 9.1 pEC50 = 9.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 485 8 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4084668 157950 0 None 43 2 Mouse 9.1 pEC50 = 9.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 485 8 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
118576930 158815 0 None 25 2 Mouse 9.1 pEC50 = 9.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 515 9 0 7 6.4 COc1cc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)ccc1F 10.1021/acs.jmedchem.6b01873
CHEMBL4094487 158815 0 None 25 2 Mouse 9.1 pEC50 = 9.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 515 9 0 7 6.4 COc1cc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)ccc1F 10.1021/acs.jmedchem.6b01873
156705093 181890 0 None 25 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 469 5 0 7 5.0 COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4779084 181890 0 None 25 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 469 5 0 7 5.0 COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
90644451 112211 0 None -3 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 459 4 0 5 6.2 Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290717 112211 0 None -3 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 459 4 0 5 6.2 Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71462787 82994 0 None -3 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.1 Cc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
CHEMBL2181229 82994 0 None -3 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.1 Cc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
90654589 109958 0 None -1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 543 7 1 8 2.5 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCN(C5COC5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234570 109958 0 None -1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 543 7 1 8 2.5 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCN(C5COC5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
46232571 202614 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2010.01.003
CHEMBL612138 202614 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2010.01.003
118103672 164450 0 None 31 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 679 14 5 8 3.6 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4213913 164450 0 None 31 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 679 14 5 8 3.6 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
90654587 109955 0 None -1 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234568 109955 0 None -1 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90654597 110005 0 None 17 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 594 9 2 8 4.1 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(C(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234868 110005 0 None 17 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 594 9 2 8 4.1 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(C(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
90654600 110008 0 None 8 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234871 110008 0 None 8 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
162645557 179674 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 323 4 0 3 3.9 C[C@H](c1ccccc1)n1cncc1C(=O)N(C)c1ccc(F)cc1 10.1016/j.bmc.2020.115972
CHEMBL4743463 179674 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 323 4 0 3 3.9 C[C@H](c1ccccc1)n1cncc1C(=O)N(C)c1ccc(F)cc1 10.1016/j.bmc.2020.115972
162669860 182745 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 378 4 0 4 3.6 C[C@H](c1ccccc1)n1cncc1C(=O)N1CCN(c2ccccc2F)CC1 10.1016/j.bmc.2020.115972
CHEMBL4790044 182745 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 378 4 0 4 3.6 C[C@H](c1ccccc1)n1cncc1C(=O)N1CCN(c2ccccc2F)CC1 10.1016/j.bmc.2020.115972
71561753 87643 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 418 6 0 5 4.9 CCN(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL2336231 87643 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 418 6 0 5 4.9 CCN(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
71561756 87645 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 446 6 0 5 5.6 Cc1ccc(CN(C(=O)c2c(C)nn(C)c2Oc2cccc(Cl)c2Cl)C(C)C)cn1 10.1016/j.bmcl.2012.12.076
CHEMBL2336233 87645 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 446 6 0 5 5.6 Cc1ccc(CN(C(=O)c2c(C)nn(C)c2Oc2cccc(Cl)c2Cl)C(C)C)cn1 10.1016/j.bmcl.2012.12.076
71599441 163553 0 None 109 2 Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4202981 163553 0 None 109 2 Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
71599441 163553 0 None 109 2 Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4202981 163553 0 None 109 2 Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
71626700 112209 0 None 7 2 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 445 4 0 5 5.9 O=C(c1cnccc1Oc1cc2ccoc2cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290715 112209 0 None 7 2 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 445 4 0 5 5.9 O=C(c1cnccc1Oc1cc2ccoc2cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
71626488 112207 0 None 3 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 426 4 0 6 5.0 Cc1noc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290713 112207 0 None 3 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 426 4 0 6 5.0 Cc1noc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
53311869 83005 0 None 3 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181239 83005 0 None 3 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
89501409 161360 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 6 7.5 COc1ccc(C(C)(C)c2cnc(SCCOCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL4126062 161360 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 6 7.5 COc1ccc(C(C)(C)c2cnc(SCCOCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
71540074 87292 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 453 7 2 6 3.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(SC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331649 87292 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 453 7 2 6 3.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(SC(F)(F)F)cc1)CC2 10.1021/ml300277t
77845059 112214 0 None 22 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 517 6 0 7 6.1 CCOC(=O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290720 112214 0 None 22 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 517 6 0 7 6.1 CCOC(=O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71561755 87283 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 438 6 0 6 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cncs1)C(C)C 10.1016/j.bmcl.2012.12.076
CHEMBL2331604 87283 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 438 6 0 6 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cncs1)C(C)C 10.1016/j.bmcl.2012.12.076
76314787 106022 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 382 5 0 5 4.1 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(Cl)cc2)c1 10.1039/C2MD20174G
CHEMBL3132966 106022 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 382 5 0 5 4.1 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(Cl)cc2)c1 10.1039/C2MD20174G
118103698 163672 0 None 12 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 724 15 5 10 2.5 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4204655 163672 0 None 12 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 724 15 5 10 2.5 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118093476 164103 0 None 39 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 780 14 6 13 2.1 Cn1c(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4209669 164103 0 None 39 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 780 14 6 13 2.1 Cn1c(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118104387 164112 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 718 15 4 8 3.0 O=C(O)CNC(=O)CNC(=O)CNC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4209799 164112 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 718 15 4 8 3.0 O=C(O)CNC(=O)CNC(=O)CNC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
145974037 164754 0 None 15 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 725 15 7 10 1.9 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4217797 164754 0 None 15 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 725 15 7 10 1.9 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4212707 213272 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL None None None O=C(O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CCC(NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O)C(=O)NCC(=O)O)NC(=O)CCC(NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
91972025 155958 0 None 43 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 540 7 0 5 7.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4061329 155958 0 None 43 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 540 7 0 5 7.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
46195848 83011 0 None 257 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
CHEMBL2181246 83011 0 None 257 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
46232694 200913 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 5 0 3 5.9 CCCc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601637 200913 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 5 0 3 5.9 CCCc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232696 201540 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 5 0 3 5.9 CCc1onc(-c2ccccc2Cl)c1C(=O)N(CC)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL605367 201540 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 5 0 3 5.9 CCc1onc(-c2ccccc2Cl)c1C(=O)N(CC)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
76318386 106025 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 391 4 0 5 4.3 COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
CHEMBL3132969 106025 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 391 4 0 5 4.3 COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
118093484 163523 0 None 31 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 617 8 1 8 5.6 Cn1c(C(=O)O)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4202656 163523 0 None 31 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 617 8 1 8 5.6 Cn1c(C(=O)O)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118093390 163870 0 None 19 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4206832 163870 0 None 19 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
118093562 163887 0 None 5 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 547 9 1 5 5.7 O=C(O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4207005 163887 0 None 5 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 547 9 1 5 5.7 O=C(O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118103738 163888 0 None - 1 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 669 12 4 6 5.0 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCP(=O)(O)O 10.1021/acs.jmedchem.8b00308
CHEMBL4207008 163888 0 None - 1 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 669 12 4 6 5.0 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCP(=O)(O)O 10.1021/acs.jmedchem.8b00308
118103697 163957 0 None 7 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4207801 163957 0 None 7 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118103728 164003 0 None - 1 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 853 20 7 12 1.8 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CC[C@H](NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
CHEMBL4208317 164003 0 None - 1 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 853 20 7 12 1.8 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CC[C@H](NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
71661092 164052 0 None 10 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 665 13 5 8 3.2 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4208999 164052 0 None 10 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 665 13 5 8 3.2 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
118103732 164086 0 None - 1 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 648 14 2 7 5.1 O=C(O)CN(CCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)CC(=O)O 10.1021/acs.jmedchem.8b00308
CHEMBL4209515 164086 0 None - 1 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 648 14 2 7 5.1 O=C(O)CN(CCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)CC(=O)O 10.1021/acs.jmedchem.8b00308
71626700 112209 0 None -7 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 445 4 0 5 5.9 O=C(c1cnccc1Oc1cc2ccoc2cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290715 112209 0 None -7 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 445 4 0 5 5.9 O=C(c1cnccc1Oc1cc2ccoc2cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
90654593 109968 0 None 2 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 530 7 2 7 3.2 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(C(=O)O)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234580 109968 0 None 2 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 530 7 2 7 3.2 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(C(=O)O)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
164613236 184506 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 541 4 2 3 8.1 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4847424 184506 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 541 4 2 3 8.1 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
155339362 173088 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 459 5 1 3 5.7 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N3CCCC3)[C@@H]21 10.1021/acs.jmedchem.9b00770
CHEMBL4519993 173088 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 459 5 1 3 5.7 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N3CCCC3)[C@@H]21 10.1021/acs.jmedchem.9b00770
71626492 112200 0 None 2 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2occc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290706 112200 0 None 2 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2occc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
168288290 191354 0 None 95 2 Human 7.0 pEC50 = 7 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 307 6 0 3 5.0 CCC(C)Oc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5192002 191354 0 None 95 2 Human 7.0 pEC50 = 7 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 307 6 0 3 5.0 CCC(C)Oc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
156016578 177706 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 399 4 2 3 5.5 C=CC[C@@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4642126 177706 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 399 4 2 3 5.5 C=CC[C@@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
118093575 163628 1 None -6 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 463 4 1 5 4.6 O=C([C@@H]1CSCN1Cc1cc(Cl)c(O)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4203848 163628 1 None -6 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 463 4 1 5 4.6 O=C([C@@H]1CSCN1Cc1cc(Cl)c(O)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118103679 163948 0 None -39 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
CHEMBL4207707 163948 0 None -39 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
118103700 163983 0 None -3 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 764 14 6 13 1.4 Cn1nc(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cc1OCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4208057 163983 0 None -3 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 764 14 6 13 1.4 Cn1nc(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cc1OCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
71661092 164052 0 None -10 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 665 13 5 8 3.2 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4208999 164052 0 None -10 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 665 13 5 8 3.2 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
118103668 164407 0 None -7 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 741 16 7 11 1.8 O=C(NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4213391 164407 0 None -7 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 741 16 7 11 1.8 O=C(NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
145972818 164642 0 None -3 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 734 13 6 12 1.3 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccn(Cc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)n1 10.1021/acs.jmedchem.8b00308
CHEMBL4216361 164642 0 None -3 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 734 13 6 12 1.3 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccn(Cc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)n1 10.1021/acs.jmedchem.8b00308
118103734 164650 0 None -25 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
CHEMBL4216584 164650 0 None -25 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
46233056 199380 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.9 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2010.01.003
CHEMBL590982 199380 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.9 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2010.01.003
73357024 92713 0 None -1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 471 5 1 3 6.4 N#CC(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435926 92713 0 None -1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 471 5 1 3 6.4 N#CC(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
71660979 163543 0 None -1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4202908 163543 0 None -1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
71660960 163590 0 None 1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
CHEMBL4203445 163590 0 None 1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
71661220 163621 0 None 1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4203777 163621 0 None 1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
168280068 191189 0 None 5 2 Human 6.0 pEC50 = 6 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 293 6 0 3 4.6 CCCOc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5189181 191189 0 None 5 2 Human 6.0 pEC50 = 6 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 293 6 0 3 4.6 CCCOc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
44457490 157929 1 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 458 5 4 5 3.3 C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL408445 157929 1 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 458 5 4 5 3.3 C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
118093441 163772 0 None 1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 C[C@@]1(C(=O)N2CCN(C3CC3)c3ccccc32)CCCN1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4205745 163772 0 None 1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 C[C@@]1(C(=O)N2CCN(C3CC3)c3ccccc32)CCCN1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
71661224 164140 0 None -1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 415 4 0 3 4.6 O=C([C@@H]1CCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4210112 164140 0 None -1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 415 4 0 3 4.6 O=C([C@@H]1CCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
71660910 164257 0 None 1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 418 6 0 3 5.2 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CC1 10.1021/acs.jmedchem.8b00308
CHEMBL4211549 164257 0 None 1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 418 6 0 3 5.2 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CC1 10.1021/acs.jmedchem.8b00308
46232410 200575 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 354 4 0 3 5.1 CCc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL599126 200575 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 354 4 0 3 5.1 CCc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
46232569 201122 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL603096 201122 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2010.01.003
71660910 164257 0 None -1 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 418 6 0 3 5.2 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CC1 10.1021/acs.jmedchem.8b00308
CHEMBL4211549 164257 0 None -1 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 418 6 0 3 5.2 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CC1 10.1021/acs.jmedchem.8b00308
89651284 164646 0 None -1 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 432 6 0 3 5.6 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CCC1 10.1021/acs.jmedchem.8b00308
CHEMBL4216520 164646 0 None -1 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 432 6 0 3 5.6 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CCC1 10.1021/acs.jmedchem.8b00308
45483949 3582 35 None -2 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2020.112619
7048 3582 35 None -2 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2020.112619
CHEMBL567640 3582 35 None -2 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2020.112619
439763 158126 22 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1039/d0md00425a
CHEMBL408701 158126 22 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1039/d0md00425a
90644448 112230 0 None -2 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 1 6 6.2 Cc1c(CCC(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
CHEMBL3290736 112230 0 None -2 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 1 6 6.2 Cc1c(CCC(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
76314788 106023 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 383 5 0 6 3.5 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(Cl)cn2)c1 10.1039/C2MD20174G
CHEMBL3132967 106023 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 383 5 0 6 3.5 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(Cl)cn2)c1 10.1039/C2MD20174G
71561884 87648 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 430 6 0 5 5.0 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CC1 10.1016/j.bmcl.2012.12.076
CHEMBL2336236 87648 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 430 6 0 5 5.0 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CC1 10.1016/j.bmcl.2012.12.076
101886302 114910 36 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assayAgonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 5 3 3 5.0 CC[C@@H]1[C@H](O)[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCO)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/jm501273r
CHEMBL3342082 114910 36 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assayAgonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 5 3 3 5.0 CC[C@@H]1[C@H](O)[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCO)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/jm501273r
136166966 91611 0 None 4 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 359 6 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407944 91611 0 None 4 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 359 6 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2013.06.017
3945 625 92 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 10.1021/jm900872z
64971 625 92 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 10.1021/jm900872z
CHEMBL269277 625 92 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 10.1021/jm900872z
DB12480 625 92 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 10.1021/jm900872z
9929677 157685 4 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 3 3 3 4.1 C[C@H](CC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL408175 157685 4 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 3 3 3 4.1 C[C@H](CC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
71561753 87643 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 418 6 0 5 4.9 CCN(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL2336231 87643 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 418 6 0 5 4.9 CCN(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
67922813 117675 1 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)O 10.1016/j.bmc.2015.01.048
CHEMBL3401352 117675 1 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)O 10.1016/j.bmc.2015.01.048
71561885 87649 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 460 6 0 6 4.7 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CCOC1 10.1016/j.bmcl.2012.12.076
CHEMBL2336237 87649 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 460 6 0 6 4.7 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CCOC1 10.1016/j.bmcl.2012.12.076
118464662 159139 0 None 22 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 687 16 0 8 7.3 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4097990 159139 0 None 22 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 687 16 0 8 7.3 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
73353937 92705 0 None -20 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 588 6 0 5 7.0 O=C(c1ccsc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435914 92705 0 None -20 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 588 6 0 5 7.0 O=C(c1ccsc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
94192 17022 19 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 388 4 1 3 4.9 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(=O)C[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.bmc.2015.01.048
CHEMBL1254261 17022 19 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 388 4 1 3 4.9 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(=O)C[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.bmc.2015.01.048
90654598 110006 0 None -21 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 9 2 8 4.4 COc1cc(C2CCN(c3cc(N4CC[C@H]4C(=O)NCCc4ccc(C#N)cc4)nc(C(F)(F)F)n3)CC2)ccc1C(=O)O 10.1021/jm401731q
CHEMBL3234869 110006 0 None -21 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 9 2 8 4.4 COc1cc(C2CCN(c3cc(N4CC[C@H]4C(=O)NCCc4ccc(C#N)cc4)nc(C(F)(F)F)n3)CC2)ccc1C(=O)O 10.1021/jm401731q
76336516 106027 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 405 5 0 5 4.6 CCc1onc(-c2cccc(OC)c2)c1C(=O)N(C)c1ccc(C(F)(F)F)nc1 10.1039/C2MD20174G
CHEMBL3132970 106027 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 405 5 0 5 4.6 CCc1onc(-c2cccc(OC)c2)c1C(=O)N(C)c1ccc(C(F)(F)F)nc1 10.1039/C2MD20174G
90654585 109953 0 None -2 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 465 6 1 7 2.1 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)nc(N2CCN(C)CC2)c1F 10.1021/jm401731q
CHEMBL3234566 109953 0 None -2 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 465 6 1 7 2.1 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)nc(N2CCN(C)CC2)c1F 10.1021/jm401731q
71540073 87291 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 in human PBMC cells assessed as increase in intracellular cAMP measured after 1 hr by human whole blood assayAgonist activity at human TGR5 in human PBMC cells assessed as increase in intracellular cAMP measured after 1 hr by human whole blood assay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331648 87291 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 in human PBMC cells assessed as increase in intracellular cAMP measured after 1 hr by human whole blood assayAgonist activity at human TGR5 in human PBMC cells assessed as increase in intracellular cAMP measured after 1 hr by human whole blood assay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71626765 118824 0 None -2 2 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 539 8 0 6 6.3 CCOC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421893 118824 0 None -2 2 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 539 8 0 6 6.3 CCOC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
118586281 158563 0 None -7 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4091702 158563 0 None -7 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1 10.1021/acs.jmedchem.6b01873
126673489 156671 0 None -13 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 571 11 0 8 6.5 COC(=O)CCc1nc(SCc2c(F)cccc2F)n(-c2ccc(F)cc2)c1N(C)c1ccc(OC)c(OC)c1 10.1021/acs.jmedchem.6b01873
CHEMBL4069569 156671 0 None -13 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 571 11 0 8 6.5 COC(=O)CCc1nc(SCc2c(F)cccc2F)n(-c2ccc(F)cc2)c1N(C)c1ccc(OC)c(OC)c1 10.1021/acs.jmedchem.6b01873
71540174 87297 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 438 7 1 6 2.4 CCOc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331654 87297 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 438 7 1 6 2.4 CCOc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71561370 87630 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 424 4 0 5 5.2 Cc1ccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c(Cl)c1 10.1016/j.bmcl.2012.12.076
CHEMBL2336215 87630 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 424 4 0 5 5.2 Cc1ccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c(Cl)c1 10.1016/j.bmcl.2012.12.076
156705090 181707 0 None -54 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 497 7 0 7 5.8 CCCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4776876 181707 0 None -54 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 497 7 0 7 5.8 CCCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
164621408 185751 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 436 5 4 4 3.9 CC[C@H]1[C@@H](O)[C@@H]2[C@H](C[C@H](O)[C@H]3[C@H]2CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@]2(C)CC[C@@H](O)C[C@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4866257 185751 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 436 5 4 4 3.9 CC[C@H]1[C@@H](O)[C@@H]2[C@H](C[C@H](O)[C@H]3[C@H]2CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@]2(C)CC[C@@H](O)C[C@H]12 10.1021/acs.jmedchem.1c00851
137629931 161016 0 None 1 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 739 18 1 9 6.4 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)N(CCCO)CCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4064764 161016 0 None 1 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 739 18 1 9 6.4 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)N(CCCO)CCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4116312 161016 0 None 1 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 739 18 1 9 6.4 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)N(CCCO)CCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
155669593 183222 0 None 31 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 392 4 0 4 4.2 O=C(c1cncn1Cc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4796107 183222 0 None 31 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 392 4 0 4 4.2 O=C(c1cncn1Cc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
3035026 95784 41 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1021/jm7015864
CHEMBL258605 95784 41 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1021/jm7015864
73353943 92731 0 None -3 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 518 6 0 3 7.8 CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 10.1016/j.ejmech.2013.07.050
CHEMBL2435945 92731 0 None -3 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 518 6 0 3 7.8 CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 10.1016/j.ejmech.2013.07.050
90327533 112224 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 602 10 1 8 5.5 CCOC(=O)CNC(=O)CCc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290730 112224 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 602 10 1 8 5.5 CCOC(=O)CNC(=O)CCc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
126673464 159164 0 None - 1 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 556 12 1 7 6.6 COc1ccc(N(C)c2c(CCCCN)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4098315 159164 0 None - 1 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 556 12 1 7 6.6 COc1ccc(N(C)c2c(CCCCN)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71561368 87628 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2ccc(Cl)cc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336213 87628 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2ccc(Cl)cc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
118709772 113560 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 460 4 0 6 5.4 CSc1ncc(C(=O)N2CCN(C)c3ccccc32)c(Oc2cc(Cl)ccc2Cl)n1 10.1016/j.bmcl.2014.07.026
CHEMBL3321843 113560 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 460 4 0 6 5.4 CSc1ncc(C(=O)N2CCN(C)c3ccccc32)c(Oc2cc(Cl)ccc2Cl)n1 10.1016/j.bmcl.2014.07.026
71455632 82988 0 None 2 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 401 5 0 5 4.5 COc1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
CHEMBL2181223 82988 0 None 2 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 401 5 0 5 4.5 COc1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
71455633 82989 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 431 6 0 6 4.5 COc1ccc(OC)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
CHEMBL2181224 82989 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 431 6 0 6 4.5 COc1ccc(OC)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
71457418 82990 0 None 1 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 385 4 0 4 4.8 Cc1ccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1 10.1021/jm301071h
CHEMBL2181225 82990 0 None 1 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 385 4 0 4 4.8 Cc1ccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1 10.1021/jm301071h
90654594 109969 0 None -3 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 544 7 2 7 3.6 CC1(C(=O)O)CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234581 109969 0 None -3 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 544 7 2 7 3.6 CC1(C(=O)O)CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
118576974 157187 0 None 10 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3ccccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4075688 157187 0 None 10 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3ccccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
46232360 199315 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 496 3 0 3 6.4 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cc(Br)c(C)c(Br)c1 10.1016/j.bmcl.2010.01.003
CHEMBL590495 199315 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 496 3 0 3 6.4 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cc(Br)c(C)c(Br)c1 10.1016/j.bmcl.2010.01.003
46232566 200812 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccc(Cl)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL600821 200812 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccc(Cl)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232532 200886 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2cccc(Cl)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601441 200886 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2cccc(Cl)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232736 201308 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL604131 201308 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232567 201381 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccccc1-c1noc(C)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL604537 201381 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccccc1-c1noc(C)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
118103692 164396 0 None - 1 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 768 17 6 11 1.9 O=C(O)CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4213249 164396 0 None - 1 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 768 17 6 11 1.9 O=C(O)CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118103668 164407 0 None 7 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 741 16 7 11 1.8 O=C(NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4213391 164407 0 None 7 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 741 16 7 11 1.8 O=C(NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
44627312 198990 1 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 496 4 2 2 8.0 C=CC[C@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
CHEMBL585494 198990 1 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 496 4 2 2 8.0 C=CC[C@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
74766512 157447 0 None 3 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 699 17 0 9 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4079040 157447 0 None 3 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 699 17 0 9 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
118464638 159535 0 None 15 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 494 6 0 6 6.4 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4102357 159535 0 None 15 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 494 6 0 6 6.4 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
71720725 87651 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 428 4 0 5 5.1 Cc1nn(C)c(Oc2cccc(Cl)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336239 87651 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 428 4 0 5 5.1 Cc1nn(C)c(Oc2cccc(Cl)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
5284060 97494 11 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 4 3 3 4.4 C[C@H](CCCO)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL270287 97494 11 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 4 3 3 4.4 C[C@H](CCCO)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
73350995 92729 0 None 1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1ccsc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435943 92729 0 None 1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1ccsc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
90654577 109945 0 None 17 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1nccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234558 109945 0 None 17 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1nccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
156020210 178146 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 401 4 2 3 5.7 CCC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4648823 178146 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 401 4 2 3 5.7 CCC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
71626833 118827 0 None 1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 11 1 7 5.8 CCOC(=O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421897 118827 0 None 1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 11 1 7 5.8 CCOC(=O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
118735268 118834 0 None 2 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1398 41 2 18 10.9 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421904 118834 0 None 2 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1398 41 2 18 10.9 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
71626559 112202 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 410 4 1 4 5.0 O=C(c1cnccc1Oc1ccc2[nH]ccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290708 112202 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 410 4 1 4 5.0 O=C(c1cnccc1Oc1ccc2[nH]ccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
118721858 116088 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 389 3 1 3 3.3 CN1CCN(C(=O)C2(C(=O)Nc3cc(F)c(F)cc3F)CC2)c2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL3356914 116088 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 389 3 1 3 3.3 CN1CCN(C(=O)C2(C(=O)Nc3cc(F)c(F)cc3F)CC2)c2ccccc21 10.1016/j.bmcl.2014.07.026
164609554 184413 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 2 3 8.3 CC(C)NC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4846090 184413 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 2 3 8.3 CC(C)NC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
45483949 3582 35 None -2 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2013.07.050
7048 3582 35 None -2 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2013.07.050
CHEMBL567640 3582 35 None -2 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2013.07.050
73353944 92732 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 532 7 0 3 8.2 CCC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 10.1016/j.ejmech.2013.07.050
CHEMBL2435946 92732 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 532 7 0 3 8.2 CCC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 10.1016/j.ejmech.2013.07.050
118455158 157579 0 None 100 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1ccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4080612 157579 0 None 100 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1ccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
71599441 163553 0 None -109 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4202981 163553 0 None -109 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
118093493 163572 0 None 3 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 664 13 6 9 1.5 O=C(CCc1cc(Cl)c(CN2CCC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4203191 163572 0 None 3 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 664 13 6 9 1.5 O=C(CCc1cc(Cl)c(CN2CCC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
71660960 163590 0 None -1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
CHEMBL4203445 163590 0 None -1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
145978106 163825 0 None 1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 539 4 0 4 4.8 O=C([C@@H]1CSCN1Cc1cc(I)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4206320 163825 0 None 1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 539 4 0 4 4.8 O=C([C@@H]1CSCN1Cc1cc(I)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093410 164784 0 None 1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 465 4 0 3 5.2 O=C([C@@H]1CC(F)(F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4218210 164784 0 None 1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 465 4 0 3 5.2 O=C([C@@H]1CC(F)(F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46233022 200764 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 452 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(I)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL600421 200764 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 452 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(I)cc1 10.1016/j.bmcl.2010.01.003
46233052 200791 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL600629 200791 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
145978106 163825 0 None -1 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 539 4 0 4 4.8 O=C([C@@H]1CSCN1Cc1cc(I)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4206320 163825 0 None -1 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 539 4 0 4 4.8 O=C([C@@H]1CSCN1Cc1cc(I)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093410 164784 0 None -1 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 465 4 0 3 5.2 O=C([C@@H]1CC(F)(F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4218210 164784 0 None -1 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 465 4 0 3 5.2 O=C([C@@H]1CC(F)(F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
222528 1368 81 None 144 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
4988 1368 81 None 144 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
610 1368 81 None 144 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
CHEMBL406393 1368 81 None 144 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
DB03619 1368 81 None 144 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
44372853 119895 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 CC(CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL349105 119895 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 CC(CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
118455158 157579 0 None -100 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 526 7 0 5 7.6 COc1ccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4080612 157579 0 None -100 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 526 7 0 5 7.6 COc1ccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
118455116 156192 0 None - 1 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 560 7 1 5 7.4 COc1cc(C2(CO)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4064131 156192 0 None - 1 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 560 7 1 5 7.4 COc1cc(C2(CO)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
46232658 199528 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 346 3 0 3 4.9 CN(C(=O)c1conc1-c1ccccc1Cl)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL592158 199528 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 346 3 0 3 4.9 CN(C(=O)c1conc1-c1ccccc1Cl)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232412 200576 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 368 4 0 3 5.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(C)C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL599127 200576 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 368 4 0 3 5.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(C)C)cc1 10.1016/j.bmcl.2010.01.003
46232875 200763 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1cccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)c1 10.1016/j.bmcl.2010.01.003
CHEMBL600410 200763 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1cccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)c1 10.1016/j.bmcl.2010.01.003
46233024 200765 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1cccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)c1 10.1016/j.bmcl.2010.01.003
CHEMBL600422 200765 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1cccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)c1 10.1016/j.bmcl.2010.01.003
46232597 201233 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2ccc(C(F)(F)F)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL603706 201233 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2ccc(C(F)(F)F)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
118093441 163772 0 None -1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 C[C@@]1(C(=O)N2CCN(C3CC3)c3ccccc32)CCCN1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4205745 163772 0 None -1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 C[C@@]1(C(=O)N2CCN(C3CC3)c3ccccc32)CCCN1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
71661223 164433 0 None 1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4213705 164433 0 None 1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232488 201577 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 368 4 0 4 4.8 CC(=O)c1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL605554 201577 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 368 4 0 4 4.8 CC(=O)c1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
71452077 83000 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 400 3 0 4 5.2 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCOc2ccccc21 10.1021/jm301071h
CHEMBL2181234 83000 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 400 3 0 4 5.2 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCOc2ccccc21 10.1021/jm301071h
73347898 92722 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 466 6 0 2 6.7 CCC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435935 92722 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 466 6 0 2 6.7 CCC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
118576974 157187 0 None -10 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3ccccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4075688 157187 0 None -10 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3ccccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
156705100 182249 0 None 4 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 567 7 0 10 5.5 Cc1oc(=O)oc1COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4783601 182249 0 None 4 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 567 7 0 10 5.5 Cc1oc(=O)oc1COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
3223370 109934 2 None -1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)C1CCCN(c2ncccn2)C1 10.1021/jm401731q
CHEMBL3234546 109934 2 None -1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)C1CCCN(c2ncccn2)C1 10.1021/jm401731q
90654580 109948 0 None 4 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 367 5 1 5 2.4 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)ncc1F 10.1021/jm401731q
CHEMBL3234561 109948 0 None 4 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 367 5 1 5 2.4 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)ncc1F 10.1021/jm401731q
90644457 112228 0 None 2 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 8 2 8 4.9 Cc1c(/C=C/C(=O)NCC(=O)O)oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
CHEMBL3290734 112228 0 None 2 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 8 2 8 4.9 Cc1c(/C=C/C(=O)NCC(=O)O)oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
90654588 109956 0 None 1 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 2 7 2.4 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234569 109956 0 None 1 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 2 7 2.4 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
164611903 185140 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 529 4 2 3 7.9 CCNC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4856750 185140 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 529 4 2 3 7.9 CCNC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
164621055 185937 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 541 4 2 4 7.0 CC(=O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4869294 185937 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 541 4 2 4 7.0 CC(=O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
11656002 83012 27 None -61 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 484 3 0 3 5.8 O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2181247 83012 27 None -61 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 484 3 0 3 5.8 O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
90654581 109949 0 None -7 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3nccc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234562 109949 0 None -7 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3nccc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
45483949 3582 35 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmcl.2013.06.017
7048 3582 35 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmcl.2013.06.017
CHEMBL567640 3582 35 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmcl.2013.06.017
118735267 118833 0 None 1 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1310 35 2 16 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421903 118833 0 None 1 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1310 35 2 16 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
164609009 184424 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 570 5 2 5 7.4 CO/N=C(/C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4846185 184424 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 570 5 2 5 7.4 CO/N=C(/C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
1434463 157745 5 None 1 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 404 4 0 6 4.4 CCn1c(=O)c2ccccc2n2c(SCc3ccc(C(F)(F)F)cc3)nnc12 10.1021/acs.jmedchem.6b01873
CHEMBL4082345 157745 5 None 1 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 404 4 0 6 4.4 CCn1c(=O)c2ccccc2n2c(SCc3ccc(C(F)(F)F)cc3)nnc12 10.1021/acs.jmedchem.6b01873
45483949 3582 35 None 2 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmc.2020.115972
7048 3582 35 None 2 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmc.2020.115972
CHEMBL567640 3582 35 None 2 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmc.2020.115972
11165617 158877 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 404 3 3 3 4.3 C[C@H]([C@@H]1C[C@@H]1C(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL409511 158877 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 404 3 3 3 4.3 C[C@H]([C@@H]1C[C@@H]1C(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
118464622 158871 0 None 26 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 548 6 0 4 8.4 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4F)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4095058 158871 0 None 26 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 548 6 0 4 8.4 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4F)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
118464720 157104 0 None - 1 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 598 6 0 4 9.2 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(C(F)(F)F)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4074596 157104 0 None - 1 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 598 6 0 4 9.2 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(C(F)(F)F)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
76332905 106029 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 391 4 0 6 3.2 COc1cccc(-c2nnn(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
CHEMBL3132972 106029 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 391 4 0 6 3.2 COc1cccc(-c2nnn(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
77845211 112219 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 503 6 1 6 5.5 O=C(O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290725 112219 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 503 6 1 6 5.5 O=C(O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
221493 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
3096 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
609 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
CHEMBL205596 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
DB02659 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
221493 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
3096 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
609 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
CHEMBL205596 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
DB02659 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
221493 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm901390p
3096 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm901390p
609 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm901390p
CHEMBL205596 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm901390p
DB02659 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm901390p
221493 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
3096 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
609 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
CHEMBL205596 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
DB02659 921 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
10140 160337 59 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 465 6 5 5 2.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL411070 160337 59 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 465 6 5 5 2.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
156705083 183096 0 None 10 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 557 8 0 10 5.5 CCOC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4794523 183096 0 None 10 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 557 8 0 10 5.5 CCOC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
71541723 87290 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 383 7 2 6 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC)cc1)CC2 10.1021/ml300277t
CHEMBL2331647 87290 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 383 7 2 6 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC)cc1)CC2 10.1021/ml300277t
156705119 183114 0 None -29 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 499 7 0 8 5.0 COCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4794753 183114 0 None -29 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 499 7 0 8 5.0 COCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
90654576 109944 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccncn2)C1 10.1021/jm401731q
CHEMBL3234557 109944 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccncn2)C1 10.1021/jm401731q
156705083 183096 0 None -10 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 557 8 0 10 5.5 CCOC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4794523 183096 0 None -10 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 557 8 0 10 5.5 CCOC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
130361963 171147 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 387 4 1 3 5.6 CO[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCC#N)[C@@H]3[C@H](O)C[C@@H]2C1 10.1021/acs.jmedchem.9b00770
CHEMBL4458539 171147 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 387 4 1 3 5.6 CO[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCC#N)[C@@H]3[C@H](O)C[C@@H]2C1 10.1021/acs.jmedchem.9b00770
71561883 87647 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 404 5 0 5 4.5 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(C)Cc1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336235 87647 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 404 5 0 5 4.5 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(C)Cc1cccnc1 10.1016/j.bmcl.2012.12.076
90654588 109956 0 None -1 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 2 7 2.4 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234569 109956 0 None -1 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 2 7 2.4 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
90654595 109970 0 None -7 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 636 10 2 8 4.6 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(Oc5ccc(CC(=O)O)cc5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234582 109970 0 None -7 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 636 10 2 8 4.6 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(Oc5ccc(CC(=O)O)cc5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
89501434 161397 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 542 11 0 6 6.9 COc1ccc(C(C)(C)c2cnc(SCCOCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL4126485 161397 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 542 11 0 6 6.9 COc1ccc(C(C)(C)c2cnc(SCCOCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
44427761 93227 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 420 4 3 3 5.0 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1[C@@H](C)[C@H]3O)C(=O)O 10.1021/jm070633p
CHEMBL244784 93227 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 420 4 3 3 5.0 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1[C@@H](C)[C@H]3O)C(=O)O 10.1021/jm070633p
90654582 109950 0 None -6 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ccnc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234563 109950 0 None -6 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ccnc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
90654569 109936 1 None -2 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234549 109936 1 None -2 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
58043589 91608 0 None 8 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407935 91608 0 None 8 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
118464804 156543 0 None -4 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 568 9 1 6 6.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(CCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4068168 156543 0 None -4 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 568 9 1 6 6.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(CCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
71561618 87639 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 457 4 0 4 6.5 Cc1ccccc1C1CCCCN1C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL2336226 87639 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 457 4 0 4 6.5 Cc1ccccc1C1CCCCN1C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
90654575 109943 0 None -1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 343 5 1 3 3.3 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccccn2)C1 10.1021/jm401731q
CHEMBL3234556 109943 0 None -1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 343 5 1 3 3.3 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccccn2)C1 10.1021/jm401731q
118735266 118832 0 None 2 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1178 26 2 13 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421902 118832 0 None 2 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1178 26 2 13 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
90644460 112222 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 602 8 1 9 4.6 CCOC(=O)CNC(=O)c1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290728 112222 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 602 8 1 9 4.6 CCOC(=O)CNC(=O)c1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
118586281 158563 0 None 7 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4091702 158563 0 None 7 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1 10.1021/acs.jmedchem.6b01873
46232736 201308 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/ml300277t
CHEMBL604131 201308 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/ml300277t
46232736 201308 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1039/C2MD20174G
CHEMBL604131 201308 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1039/C2MD20174G
71599441 163553 0 None -109 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4202981 163553 0 None -109 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
156705091 182207 0 None -20 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 515 7 0 8 5.7 CSCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4783037 182207 0 None -20 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 515 7 0 8 5.7 CSCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
64945 58991 76 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 1 2 2 7.1 C[C@@H]1[C@H]2C3=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]4(C)[C@]3(C)CC[C@@]2(C(=O)O)CC[C@H]1C 10.1021/jm900872z
CHEMBL169 58991 76 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 1 2 2 7.1 C[C@@H]1[C@H]2C3=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]4(C)[C@]3(C)CC[C@@]2(C(=O)O)CC[C@H]1C 10.1021/jm900872z
156705115 182119 0 None 3 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 527 7 0 9 4.9 CC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4782069 182119 0 None 3 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 527 7 0 9 4.9 CC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
447718 97497 8 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CCCC[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL270311 97497 8 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CCCC[C@H]1C[C@H]3O 10.1021/jm7015864
71540076 87294 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 417 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331651 87294 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 417 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)cc1)CC2 10.1021/ml300277t
71561365 87625 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 410 4 0 5 4.9 Cc1nn(C)c(Oc2ccccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336210 87625 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 410 4 0 5 4.9 Cc1nn(C)c(Oc2ccccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
71540073 87291 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant TGR5 expressed in NCI-H716 cells assessed as increase in intracellular cAMP measured after 1 hrAgonist activity at human recombinant TGR5 expressed in NCI-H716 cells assessed as increase in intracellular cAMP measured after 1 hr
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331648 87291 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant TGR5 expressed in NCI-H716 cells assessed as increase in intracellular cAMP measured after 1 hrAgonist activity at human recombinant TGR5 expressed in NCI-H716 cells assessed as increase in intracellular cAMP measured after 1 hr
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71626558 112203 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 410 4 1 4 5.0 O=C(c1cnccc1Oc1cccc2[nH]ccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290709 112203 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 410 4 1 4 5.0 O=C(c1cnccc1Oc1cccc2[nH]ccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
71561369 87629 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cc(Cl)ccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336214 87629 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cc(Cl)ccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
11281589 117678 13 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 420 5 3 3 5.1 CC[C@H]1[C@H](O)[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCC(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
CHEMBL3401355 117678 13 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 420 5 3 3 5.1 CC[C@H]1[C@H](O)[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCC(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
71561365 87625 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 410 4 0 5 4.9 Cc1nn(C)c(Oc2ccccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336210 87625 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 410 4 0 5 4.9 Cc1nn(C)c(Oc2ccccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
71561614 87631 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.3 Cc1nn(C)c(Oc2ccccc2C(F)(F)F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336216 87631 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.3 Cc1nn(C)c(Oc2ccccc2C(F)(F)F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
71626560 112206 0 None 3 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 428 4 0 6 5.1 O=C(c1cnccc1Oc1ccc2ncsc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290712 112206 0 None 3 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 428 4 0 6 5.1 O=C(c1cnccc1Oc1ccc2ncsc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
90654600 110008 0 None -8 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234871 110008 0 None -8 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
71457418 82990 0 None -1 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 385 4 0 4 4.8 Cc1ccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1 10.1021/jm301071h
CHEMBL2181225 82990 0 None -1 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 385 4 0 4 4.8 Cc1ccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1 10.1021/jm301071h
46233021 200814 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 404 3 0 3 5.3 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Br)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL600827 200814 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 404 3 0 3 5.3 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Br)cc1 10.1016/j.bmcl.2010.01.003
118093575 163628 1 None 6 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 463 4 1 5 4.6 O=C([C@@H]1CSCN1Cc1cc(Cl)c(O)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4203848 163628 1 None 6 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 463 4 1 5 4.6 O=C([C@@H]1CSCN1Cc1cc(Cl)c(O)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118104397 164173 0 None 15 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 750 14 6 12 2.2 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)o1 10.1021/acs.jmedchem.8b00308
CHEMBL4210547 164173 0 None 15 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 750 14 6 12 2.2 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)o1 10.1021/acs.jmedchem.8b00308
73352466 92711 0 None -4 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 453 5 1 3 6.3 N#CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435924 92711 0 None -4 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 453 5 1 3 6.3 N#CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
447715 196927 68 None 9 7 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acs.jmedchem.6b01126
CHEMBL566315 196927 68 None 9 7 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acs.jmedchem.6b01126
71626229 118831 0 None -2 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 9 1 6 5.3 CN(CC(=O)O)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421901 118831 0 None -2 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 9 1 6 5.3 CN(CC(=O)O)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
164628742 186570 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 595 4 2 3 9.6 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)Nc6ccc(F)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4878269 186570 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 595 4 2 3 9.6 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)Nc6ccc(F)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
118464786 156630 0 None - 1 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 530 6 0 4 8.2 COc1ccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4069164 156630 0 None - 1 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 530 6 0 4 8.2 COc1ccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1Cl 10.1021/acsmedchemlett.7b00116
24969872 17669 0 None 10 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1021/ml300277t
CHEMBL1258423 17669 0 None 10 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1021/ml300277t
71540075 87293 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 435 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331650 87293 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 435 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC(F)(F)F)cc1)CC2 10.1021/ml300277t
53311618 83015 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 3 0 4 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
CHEMBL2181251 83015 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 3 0 4 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
118586298 158026 0 None -2 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 449 8 0 6 6.1 COc1ccc(N(C)c2cnc(SCc3ccccc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4085664 158026 0 None -2 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 449 8 0 6 6.1 COc1ccc(N(C)c2cnc(SCc3ccccc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
10133 910 78 None -1 4 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
145714624 910 78 None -1 4 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
4361 910 78 None -1 4 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
608 910 78 None -1 4 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
CHEMBL240597 910 78 None -1 4 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
DB06777 910 78 None -1 4 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
71541719 87289 1 None 194 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
CHEMBL2331646 87289 1 None 194 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
44605616 198295 67 None 28 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayAgonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/jm901434t
CHEMBL575966 198295 67 None 28 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayAgonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/jm901434t
118093402 164220 0 None 1 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4211041 164220 0 None 1 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232529 200853 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2F)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601233 200853 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2F)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
118104385 163583 0 None 5 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 648 13 6 10 0.7 O=C(CCc1ccc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)c1)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4203321 163583 0 None 5 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 648 13 6 10 0.7 O=C(CCc1ccc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)c1)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
118464806 159057 0 None -34 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4097059 159057 0 None -34 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
71661222 164497 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 O=C([C@@H]1CCCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4214506 164497 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 O=C([C@@H]1CCCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
71660822 164765 0 None -5 2 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 461 4 0 4 4.9 O=C([C@@H]1CSCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4217961 164765 0 None -5 2 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 461 4 0 4 4.9 O=C([C@@H]1CSCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
71561504 87635 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@@H]1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336222 87635 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@@H]1c1cccnc1 10.1016/j.bmcl.2012.12.076
71626697 112205 0 None 3 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 427 4 0 5 5.7 O=C(c1cnccc1Oc1ccc2sccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290711 112205 0 None 3 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 427 4 0 5 5.7 O=C(c1cnccc1Oc1ccc2sccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
90644456 112225 0 None -1 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 557 7 0 7 6.8 CCOC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290731 112225 0 None -1 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 557 7 0 7 6.8 CCOC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
156705098 183394 2 None 12 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 513 8 0 8 5.4 CCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4798091 183394 2 None 12 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 513 8 0 8 5.4 CCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
137634612 156115 0 None 35 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 518 9 0 6 7.4 COc1ccc(SCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4063237 156115 0 None 35 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 518 9 0 6 7.4 COc1ccc(SCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
145955827 162682 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 504 5 4 4 4.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)N3CC[C@H](O)C3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4170310 162682 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 504 5 4 4 4.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)N3CC[C@H](O)C3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
71461057 83010 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 403 5 0 5 4.9 COc1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl 10.1021/jm301071h
CHEMBL2181244 83010 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 403 5 0 5 4.9 COc1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl 10.1021/jm301071h
76322065 106024 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 417 5 0 6 3.8 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
CHEMBL3132968 106024 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 417 5 0 6 3.8 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
90654573 109941 0 None -1 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 362 5 1 4 2.8 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncc(F)cn2)C1 10.1021/jm401731q
CHEMBL3234554 109941 0 None -1 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 362 5 1 4 2.8 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncc(F)cn2)C1 10.1021/jm401731q
90654565 109964 0 None 1 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234576 109964 0 None 1 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
136166950 91602 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407929 91602 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
130361811 156391 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 445 4 2 3 5.0 C[C@H](CCC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL4066443 156391 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 445 4 2 3 5.0 C[C@H](CCC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
71626491 112204 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 410 4 1 4 5.0 O=C(c1cnccc1Oc1ccc2cc[nH]c2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290710 112204 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 410 4 1 4 5.0 O=C(c1cnccc1Oc1ccc2cc[nH]c2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
71462788 82998 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 417 3 0 5 5.3 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 10.1021/jm301071h
CHEMBL2181232 82998 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 417 3 0 5 5.3 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 10.1021/jm301071h
9838552 192092 56 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 279 4 1 3 3.5 O=C(O)c1ccc(OCc2ccc3ccccc3n2)cc1 10.1021/acs.jmedchem.1c01078
CHEMBL5202995 192092 56 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 279 4 1 3 3.5 O=C(O)c1ccc(OCc2ccc3ccccc3n2)cc1 10.1021/acs.jmedchem.1c01078
45483949 3582 35 None -2 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml300277t
7048 3582 35 None -2 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml300277t
CHEMBL567640 3582 35 None -2 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml300277t
137641119 157009 0 None -28 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 636 12 0 8 6.2 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)/N=C/N(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4073356 157009 0 None -28 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 636 12 0 8 6.2 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)/N=C/N(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
77845060 112218 0 None -7 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 489 5 1 6 5.6 O=C(O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL3290724 112218 0 None -7 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 489 5 1 6 5.6 O=C(O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
1434463 157745 5 None -1 2 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 404 4 0 6 4.4 CCn1c(=O)c2ccccc2n2c(SCc3ccc(C(F)(F)F)cc3)nnc12 10.1021/acs.jmedchem.6b01873
CHEMBL4082345 157745 5 None -1 2 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 404 4 0 6 4.4 CCn1c(=O)c2ccccc2n2c(SCc3ccc(C(F)(F)F)cc3)nnc12 10.1021/acs.jmedchem.6b01873
71626489 112194 0 None 3 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 421 4 0 4 5.7 O=C(c1cnccc1Oc1cccc2ccccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290700 112194 0 None 3 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 421 4 0 4 5.7 O=C(c1cnccc1Oc1cccc2ccccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
90654581 109949 0 None 7 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3nccc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234562 109949 0 None 7 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3nccc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
90654592 109961 0 None 2 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 517 7 1 9 1.9 CCN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4cnc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234573 109961 0 None 2 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 517 7 1 9 1.9 CCN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4cnc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
118577298 160986 0 None 18 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4086463 160986 0 None 18 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4096633 160986 0 None 18 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116110 160986 0 None 18 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
66739980 139465 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 514 8 0 5 7.4 COc1ccc(C(C)(C)c2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL3794175 139465 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 514 8 0 5 7.4 COc1ccc(C(C)(C)c2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
89501851 161544 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 540 11 0 6 7.3 COc1ccc(C(C)(C)c2cnc(SCCOCc3cccc(Cl)c3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL4128655 161544 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 540 11 0 6 7.3 COc1ccc(C(C)(C)c2cnc(SCCOCc3cccc(Cl)c3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
164611905 185141 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 515 3 2 3 7.5 CNC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4856752 185141 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 515 3 2 3 7.5 CNC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
168277662 190172 1 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 321 7 0 3 5.2 CCC(C)COc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5173976 190172 1 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 321 7 0 3 5.2 CCC(C)COc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
58043414 91617 0 None 38 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 424 5 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407951 91617 0 None 38 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 424 5 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
90654586 109954 0 None 2 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1nc(N2CCN(C)CC2)cc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234567 109954 0 None 2 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1nc(N2CCN(C)CC2)cc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
71626833 118827 0 None -1 2 Mouse 4.8 pEC50 = 4.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 11 1 7 5.8 CCOC(=O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421897 118827 0 None -1 2 Mouse 4.8 pEC50 = 4.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 11 1 7 5.8 CCOC(=O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
101882379 114247 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assayAgonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assay
ChEMBL 420 6 3 3 5.3 C[C@H](CCCCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm500889f
CHEMBL3330019 114247 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assayAgonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assay
ChEMBL 420 6 3 3 5.3 C[C@H](CCCCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm500889f
52905075 158759 8 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 445 4 2 3 5.0 C[C@H](CCC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acs.jmedchem.9b00770
CHEMBL4093987 158759 8 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 445 4 2 3 5.0 C[C@H](CCC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acs.jmedchem.9b00770
164617191 184512 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 613 6 4 4 7.1 CC(C)[C@@H]1CC[C@]2(NC(=O)NCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4847526 184512 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 613 6 4 4 7.1 CC(C)[C@@H]1CC[C@]2(NC(=O)NCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
164608751 184453 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 567 4 3 4 8.1 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)Nc6cc[nH]n6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4846632 184453 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 567 4 3 4 8.1 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)Nc6cc[nH]n6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
10790510 101272 1 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 469 2 2 3 7.6 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL296302 101272 1 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 469 2 2 3 7.6 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
155669596 180669 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 358 4 0 4 3.6 O=C(c1cncn1Cc1ccccc1)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4755237 180669 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 358 4 0 4 3.6 O=C(c1cncn1Cc1ccccc1)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
118577298 160986 0 None -18 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4086463 160986 0 None -18 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4096633 160986 0 None -18 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116110 160986 0 None -18 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
121355127 162811 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 444 5 3 5 4.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCc3nn[nH]n3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4172477 162811 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 444 5 3 5 4.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCc3nn[nH]n3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
118709776 113564 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 389 3 2 3 4.2 O=C(Nc1cc(Cl)ccc1Cl)C1(C(=O)N2CCNc3ccccc32)CC1 10.1016/j.bmcl.2014.07.026
CHEMBL3321849 113564 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 389 3 2 3 4.2 O=C(Nc1cc(Cl)ccc1Cl)C1(C(=O)N2CCNc3ccccc32)CC1 10.1016/j.bmcl.2014.07.026
90644449 112199 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1cccc2cccnc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290705 112199 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1cccc2cccnc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
137646061 157815 0 None -3 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 502 9 0 6 6.7 COc1ccc(OCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4083324 157815 0 None -3 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 502 9 0 6 6.7 COc1ccc(OCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
71561885 87649 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 460 6 0 6 4.7 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CCOC1 10.1016/j.bmcl.2012.12.076
CHEMBL2336237 87649 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 460 6 0 6 4.7 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CCOC1 10.1016/j.bmcl.2012.12.076
90644444 112229 0 None 4 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 587 8 0 8 6.1 CCOC(=O)CCc1oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290735 112229 0 None 4 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 587 8 0 8 6.1 CCOC(=O)CCc1oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
90654597 110005 0 None -17 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 594 9 2 8 4.1 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(C(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234868 110005 0 None -17 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 594 9 2 8 4.1 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(C(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
90644458 112226 0 None 1 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 529 6 1 6 6.3 Cc1c(/C=C/C(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
CHEMBL3290732 112226 0 None 1 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 529 6 1 6 6.3 Cc1c(/C=C/C(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
53311869 83005 0 None -3 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181239 83005 0 None -3 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
164628005 186486 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 555 4 2 4 7.2 CC1(C)[C@H](OC(=O)NC2CC2)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@H]3[C@H]([C@@]4(C)CO4)CC[C@]3(C(=O)O)CC[C@]21C 10.1021/acs.jmedchem.1c00851
CHEMBL4877060 186486 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 555 4 2 4 7.2 CC1(C)[C@H](OC(=O)NC2CC2)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@H]3[C@H]([C@@]4(C)CO4)CC[C@]3(C(=O)O)CC[C@]21C 10.1021/acs.jmedchem.1c00851
118586282 159555 0 None 23 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 486 8 0 7 5.8 COc1ccc(N(C)c2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4102610 159555 0 None 23 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 486 8 0 7 5.8 COc1ccc(N(C)c2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
168270223 190065 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 321 8 0 3 5.4 CCCCCOc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5172427 190065 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 321 8 0 3 5.4 CCCCCOc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
6013 141870 49 None -575 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 288 0 1 2 3.9 C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
CHEMBL386630 141870 49 None -575 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 288 0 1 2 3.9 C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
137651596 157128 0 None - 1 Mouse 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 546 6 0 4 8.7 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(Cl)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4075062 157128 0 None - 1 Mouse 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 546 6 0 4 8.7 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(Cl)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
118464638 159535 0 None -15 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 494 6 0 6 6.4 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4102357 159535 0 None -15 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 494 6 0 6 6.4 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
11656002 83012 27 None 61 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 484 3 0 3 5.8 O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2181247 83012 27 None 61 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 484 3 0 3 5.8 O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
90654568 109967 0 None -4 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 7 1 8 1.8 CCN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)nc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234579 109967 0 None -4 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 7 1 8 1.8 CCN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)nc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
46232361 200506 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 354 3 0 3 5.2 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1C 10.1016/j.bmcl.2010.01.003
CHEMBL598743 200506 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 354 3 0 3 5.2 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1C 10.1016/j.bmcl.2010.01.003
46232414 200612 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL599328 200612 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2010.01.003
46232598 200958 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 326 3 0 3 4.6 Cc1onc(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601882 200958 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 326 3 0 3 4.6 Cc1onc(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232660 201264 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 4 0 3 6.0 CC(C)c1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL603921 201264 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 4 0 3 6.0 CC(C)c1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
90654583 109951 0 None -2 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1cc(N2CCN(C)CC2)nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234564 109951 0 None -2 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1cc(N2CCN(C)CC2)nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
130361919 157108 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 459 5 1 3 5.7 CO[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCC(=O)N4CCCC4)[C@@H]3[C@H](O)C[C@@H]2C1 10.1021/acs.jmedchem.9b00770
CHEMBL4074652 157108 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 459 5 1 3 5.7 CO[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCC(=O)N4CCCC4)[C@@H]3[C@H](O)C[C@@H]2C1 10.1021/acs.jmedchem.9b00770
387316 66769 48 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL185878 66769 48 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
126700763 158453 0 None - 1 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 557 11 1 7 6.4 COc1ccc(N(C)c2c(CCC(=O)O)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4090586 158453 0 None - 1 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 557 11 1 7 6.4 COc1ccc(N(C)c2c(CCC(=O)O)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
118103740 163554 0 None -25 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cn1 10.1021/acs.jmedchem.8b00308
CHEMBL4202994 163554 0 None -25 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cn1 10.1021/acs.jmedchem.8b00308
71661220 163621 0 None -1 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4203777 163621 0 None -1 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093390 163870 0 None -19 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4206832 163870 0 None -19 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
71661186 164282 0 None -3 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 532 9 1 5 5.6 NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4211892 164282 0 None -3 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 532 9 1 5 5.6 NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118093420 164545 0 None 1 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
CHEMBL4215113 164545 0 None 1 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
155528730 171379 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 469 5 3 5 3.5 C[C@H](CCC(=O)NS(C)(=O)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL4461961 171379 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 469 5 3 5 3.5 C[C@H](CCC(=O)NS(C)(=O)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
118093418 164095 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 O=C([C@H]1CCCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4209597 164095 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 O=C([C@H]1CCCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232986 200790 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccccc1Cl 10.1016/j.bmcl.2010.01.003
CHEMBL600624 200790 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccccc1Cl 10.1016/j.bmcl.2010.01.003
71661222 164497 0 None -1 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 O=C([C@@H]1CCCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4214506 164497 0 None -1 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 O=C([C@@H]1CCCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
44605616 198295 67 None -28 2 Rat 5.7 pEC50 = 5.7 Functional
Agonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/jm901434t
CHEMBL575966 198295 67 None -28 2 Rat 5.7 pEC50 = 5.7 Functional
Agonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/jm901434t
90654584 109952 0 None 1 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(C(F)(F)F)nc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)n2)CC1 10.1021/jm401731q
CHEMBL3234565 109952 0 None 1 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(C(F)(F)F)nc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)n2)CC1 10.1021/jm401731q
71540078 87296 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 422 6 1 5 2.6 CCc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331653 87296 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 422 6 1 5 2.6 CCc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71455634 82992 0 None -4 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 473 4 0 4 6.5 O=C(c1cnccc1Oc1cc(Cl)c(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181227 82992 0 None -4 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 473 4 0 4 6.5 O=C(c1cnccc1Oc1cc(Cl)c(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
90654566 109965 0 None 1 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 473 6 1 7 2.1 CN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234577 109965 0 None 1 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 473 6 1 7 2.1 CN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90654595 109970 0 None 7 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 636 10 2 8 4.6 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(Oc5ccc(CC(=O)O)cc5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234582 109970 0 None 7 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 636 10 2 8 4.6 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(Oc5ccc(CC(=O)O)cc5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
90654596 109971 0 None 15 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 10 2 8 4.0 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(CC(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234583 109971 0 None 15 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 10 2 8 4.0 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(CC(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
90654599 110007 0 None 12 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 571 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc(-c4ccc(C(=O)O)cc4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234870 110007 0 None 12 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 571 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc(-c4ccc(C(=O)O)cc4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
118576958 158405 0 None 17 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 519 8 0 6 7.0 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)c(Cl)c2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4090147 158405 0 None 17 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 519 8 0 6 7.0 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)c(Cl)c2)cc1OC 10.1021/acs.jmedchem.6b01873
156705090 181707 0 None 54 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 497 7 0 7 5.8 CCCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4776876 181707 0 None 54 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 497 7 0 7 5.8 CCCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
76322064 106021 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 370 5 0 5 3.8 CCc1nnn(-c2cccc(OC)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1039/C2MD20174G
CHEMBL3132965 106021 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 370 5 0 5 3.8 CCc1nnn(-c2cccc(OC)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1039/C2MD20174G
71462786 82993 0 None -3 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 413 4 0 4 5.4 Cc1cc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1C 10.1021/jm301071h
CHEMBL2181228 82993 0 None -3 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 413 4 0 4 5.4 Cc1cc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1C 10.1021/jm301071h
71540073 87291 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1016/j.bmcl.2012.12.076
CHEMBL2331648 87291 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1016/j.bmcl.2012.12.076
145962358 161441 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 531 11 0 7 6.5 COc1ccc(C(C)(C)c2cnc(SCCOCc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL4127302 161441 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 531 11 0 7 6.5 COc1ccc(C(C)(C)c2cnc(SCCOCc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
71540073 87291 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331648 87291 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71461054 82996 0 None -3 2 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 467 5 0 4 6.4 CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
CHEMBL2181230 82996 0 None -3 2 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 467 5 0 4 6.4 CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
71561882 87646 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 446 7 0 5 5.7 CCC(C)N(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL2336234 87646 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 446 7 0 5 5.7 CCC(C)N(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
71626699 112210 0 None -5 2 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 425 4 0 5 5.6 Cc1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290716 112210 0 None -5 2 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 425 4 0 5 5.6 Cc1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71541719 87289 1 None 194 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
CHEMBL2331646 87289 1 None 194 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
118103679 163948 0 None 39 2 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
CHEMBL4207707 163948 0 None 39 2 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
118103737 164831 0 None - 1 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 738 12 3 7 5.1 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)N1CCN(CP(=O)(O)O)CC1 10.1021/acs.jmedchem.8b00308
CHEMBL4218746 164831 0 None - 1 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 738 12 3 7 5.1 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)N1CCN(CP(=O)(O)O)CC1 10.1021/acs.jmedchem.8b00308
71540076 87294 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 417 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331651 87294 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 417 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)cc1)CC2 10.1021/ml300277t
156705112 182864 0 None 15 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 483 6 0 7 5.4 CCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4791709 182864 0 None 15 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 483 6 0 7 5.4 CCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
71450252 83006 0 None 10 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.2 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181240 83006 0 None 10 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.2 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 10.1021/jm301071h
71540175 87298 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 434 6 1 5 2.9 NC(=O)c1nc(C2CC2)nc2c1CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331655 87298 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 434 6 1 5 2.9 NC(=O)c1nc(C2CC2)nc2c1CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
53311869 83005 0 None 3 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL2181239 83005 0 None 3 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
71452080 83020 0 None 10 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 440 4 0 5 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181256 83020 0 None 10 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 440 4 0 5 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
118709771 113528 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 429 3 2 6 4.3 CN1CCN(C(=O)c2cnc(O)nc2Nc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL3321758 113528 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 429 3 2 6 4.3 CN1CCN(C(=O)c2cnc(O)nc2Nc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
71452078 83016 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 428 4 0 5 5.1 CCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181252 83016 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 428 4 0 5 5.1 CCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
90654563 109962 0 None 1 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.8 CN1CCN(c2cc(N3CCCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234574 109962 0 None 1 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.8 CN1CCN(c2cc(N3CCCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
118576930 158815 0 None -25 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 515 9 0 7 6.4 COc1cc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)ccc1F 10.1021/acs.jmedchem.6b01873
CHEMBL4094487 158815 0 None -25 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 515 9 0 7 6.4 COc1cc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)ccc1F 10.1021/acs.jmedchem.6b01873
90655904 112806 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Transactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive element containing luciferase reporter gene assayTransactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive element containing luciferase reporter gene assay
ChEMBL 486 7 3 5 4.8 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCCOS(=O)(=O)O)[C@@H]2[C@@H]1O 10.1021/jm401873d
CHEMBL3260994 112806 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Transactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive element containing luciferase reporter gene assayTransactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive element containing luciferase reporter gene assay
ChEMBL 486 7 3 5 4.8 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCCOS(=O)(=O)O)[C@@H]2[C@@H]1O 10.1021/jm401873d
CHEMBL3306811 112806 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Transactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive element containing luciferase reporter gene assayTransactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive element containing luciferase reporter gene assay
ChEMBL 486 7 3 5 4.8 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCCOS(=O)(=O)O)[C@@H]2[C@@H]1O 10.1021/jm401873d
56601732 91605 0 None 1 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407932 91605 0 None 1 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
168276623 190411 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 295 4 2 4 3.2 O=C(O)c1cc(O)cc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5177797 190411 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 295 4 2 4 3.2 O=C(O)c1cc(O)cc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
118735267 118833 0 None -1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1310 35 2 16 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421903 118833 0 None -1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1310 35 2 16 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
447715 196927 68 None 9 7 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1016/j.bmc.2011.03.004
CHEMBL566315 196927 68 None 9 7 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1016/j.bmc.2011.03.004
73350992 92709 0 None 10 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 442 5 1 2 6.8 CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435921 92709 0 None 10 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 442 5 1 2 6.8 CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
73350992 92709 0 None -10 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 442 5 1 2 6.8 CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435921 92709 0 None -10 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 442 5 1 2 6.8 CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
118464724 159465 0 None -61 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 528 7 0 6 6.8 COc1ccc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4101442 159465 0 None -61 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 528 7 0 6 6.8 COc1ccc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
137651232 157368 0 None 20 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 570 10 1 9 6.1 COc1ccc(SCc2cnc(SCc3c(F)cc(-c4nn[nH]n4)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4077972 157368 0 None 20 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 570 10 1 9 6.1 COc1ccc(SCc2cnc(SCc3c(F)cc(-c4nn[nH]n4)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
137629931 161016 0 None -1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 739 18 1 9 6.4 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)N(CCCO)CCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4064764 161016 0 None -1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 739 18 1 9 6.4 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)N(CCCO)CCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4116312 161016 0 None -1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 739 18 1 9 6.4 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)N(CCCO)CCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
44627311 197282 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 496 4 2 2 8.0 C=CC[C@@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
CHEMBL568584 197282 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 496 4 2 2 8.0 C=CC[C@@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
156705098 183394 2 None -12 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 513 8 0 8 5.4 CCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4798091 183394 2 None -12 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 513 8 0 8 5.4 CCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
66740913 158655 0 None 22 2 Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 471 8 0 6 5.6 COc1ccc(Cc2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4092629 158655 0 None 22 2 Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 471 8 0 6 5.6 COc1ccc(Cc2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
89501422 161631 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 531 11 0 7 6.5 COc1ccc(C(C)(C)c2cnc(SCCOCc3cccc(C#N)c3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL4130025 161631 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 531 11 0 7 6.5 COc1ccc(C(C)(C)c2cnc(SCCOCc3cccc(C#N)c3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
118464747 158334 0 None 4 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 743 19 2 10 6.0 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)NCCOCCOCCOCCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4089352 158334 0 None 4 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 743 19 2 10 6.0 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)NCCOCCOCCOCCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
73357025 92718 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 568 7 0 3 7.3 O=S(=O)(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1)Cc1cnccc1-c1ccccc1F 10.1016/j.ejmech.2013.07.050
CHEMBL2435931 92718 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 568 7 0 3 7.3 O=S(=O)(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1)Cc1cnccc1-c1ccccc1F 10.1016/j.ejmech.2013.07.050
90654577 109945 0 None -17 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1nccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234558 109945 0 None -17 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1nccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
156705085 182987 0 None -2 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 543 10 0 9 5.0 COCCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4793377 182987 0 None -2 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 543 10 0 9 5.0 COCCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
164628559 186546 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 1 3 8.3 CCN(C)C(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4877942 186546 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 1 3 8.3 CCN(C)C(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
71718878 87650 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1016/j.bmcl.2012.12.076
CHEMBL2336238 87650 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1016/j.bmcl.2012.12.076
71718878 87650 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1039/C2MD20174G
CHEMBL2336238 87650 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1039/C2MD20174G
118464713 159297 0 None - 1 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 516 6 0 5 6.9 COc1cc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4099616 159297 0 None - 1 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 516 6 0 5 6.9 COc1cc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
71541722 87288 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 381 7 2 5 2.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC)cc1)CC2 10.1021/ml300277t
CHEMBL2331645 87288 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 381 7 2 5 2.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC)cc1)CC2 10.1021/ml300277t
77845060 112218 0 None 7 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 489 5 1 6 5.6 O=C(O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL3290724 112218 0 None 7 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 489 5 1 6 5.6 O=C(O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
44337790 7087 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 458 2 2 2 7.2 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)C(CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C12 10.1021/jm900872z
CHEMBL108505 7087 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 458 2 2 2 7.2 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)C(CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C12 10.1021/jm900872z
90654572 109940 0 None 1 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ncccn3)C2)cc1 10.1021/jm401731q
CHEMBL3234553 109940 0 None 1 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ncccn3)C2)cc1 10.1021/jm401731q
137634963 155881 0 None -21 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 529 10 0 6 6.3 COc1ccc(N(C=O)Cc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4060463 155881 0 None -21 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 529 10 0 6 6.3 COc1ccc(N(C=O)Cc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
5284061 16976 15 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 4 3 3 4.4 C[C@H](CCCO)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL1253814 16976 15 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 4 3 3 4.4 C[C@H](CCCO)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
66737876 117674 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 390 4 2 2 5.8 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)O 10.1016/j.bmc.2015.01.048
CHEMBL3401351 117674 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 390 4 2 2 5.8 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)O 10.1016/j.bmc.2015.01.048
90654578 109946 0 None 3 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1cccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234559 109946 0 None 3 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1cccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
155534242 171923 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 430 4 2 5 4.9 Cc1nnc(CC[C@@H](C)[C@H]2CC[C@H]3[C@H]4[C@H](CC[C@@]32C)[C@@]2(C)CC[C@@H](O)C[C@H]2C[C@H]4O)o1 10.1021/acs.jmedchem.9b00770
CHEMBL4470072 171923 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 430 4 2 5 4.9 Cc1nnc(CC[C@@H](C)[C@H]2CC[C@H]3[C@H]4[C@H](CC[C@@]32C)[C@@]2(C)CC[C@@H](O)C[C@H]2C[C@H]4O)o1 10.1021/acs.jmedchem.9b00770
10494 2916 81 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 1 2 2 7.2 O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C 10.1021/jm900872z
3306 2916 81 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 1 2 2 7.2 O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C 10.1021/jm900872z
CHEMBL168 2916 81 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 1 2 2 7.2 O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C 10.1021/jm900872z
156019954 177995 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 385 3 2 3 5.1 C=C[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4646264 177995 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 385 3 2 3 5.1 C=C[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
164613461 184990 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 607 5 2 4 9.4 COc1ccc(NC(=O)O[C@@H]2CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3CC[C@@H]3[C@H]5[C@H](C(C)C)CC[C@]5(C(=O)O)CC[C@]34C)C2(C)C)cc1 10.1021/acs.jmedchem.1c00851
CHEMBL4854339 184990 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 607 5 2 4 9.4 COc1ccc(NC(=O)O[C@@H]2CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3CC[C@@H]3[C@H]5[C@H](C(C)C)CC[C@]5(C(=O)O)CC[C@]34C)C2(C)C)cc1 10.1021/acs.jmedchem.1c00851
44457460 96115 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 394 4 2 2 5.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](F)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL260314 96115 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 394 4 2 2 5.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](F)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
44605617 198319 1 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL576138 198319 1 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1016/j.bmcl.2012.12.076
71452076 82997 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 454 4 0 5 5.6 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181231 82997 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 454 4 0 5 5.6 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 10.1021/jm301071h
90654582 109950 0 None 6 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ccnc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234563 109950 0 None 6 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ccnc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
156705093 181890 0 None -25 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 469 5 0 7 5.0 COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4779084 181890 0 None -25 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 469 5 0 7 5.0 COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
162665892 182325 0 None 16 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 537 6 0 7 6.0 O=C(OCC(F)(F)F)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4784355 182325 0 None 16 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 537 6 0 7 6.0 O=C(OCC(F)(F)F)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
73350995 92729 0 None -1 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1ccsc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435943 92729 0 None -1 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1ccsc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
137630517 161070 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 631 13 1 7 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4083747 161070 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 631 13 1 7 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4116717 161070 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 631 13 1 7 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
387316 66769 48 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1016/j.ejmech.2015.09.024
CHEMBL185878 66769 48 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1016/j.ejmech.2015.09.024
168281036 190956 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 281 4 2 4 3.0 OCc1cc(O)cc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5185938 190956 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 281 4 2 4 3.0 OCc1cc(O)cc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
71561366 87626 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336211 87626 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
44457491 96395 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 481 7 2 3 5.7 C[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL261826 96395 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 481 7 2 3 5.7 C[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@H]12 10.1021/jm7015864
118576918 161131 0 None -24 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 654 13 0 8 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4078612 161131 0 None -24 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 654 13 0 8 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4117224 161131 0 None -24 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 654 13 0 8 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
31401 48109 80 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.bmc.2015.01.048
CHEMBL1551 48109 80 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.bmc.2015.01.048
90644446 112216 0 None 3 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 559 7 0 8 5.4 COC(=O)CCc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290722 112216 0 None 3 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 559 7 0 8 5.4 COC(=O)CCc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
44605617 198319 1 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/ml300277t
CHEMBL576138 198319 1 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/ml300277t
118577239 160983 0 None -60 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 623 13 1 9 6.0 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4060410 160983 0 None -60 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 623 13 1 9 6.0 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116055 160983 0 None -60 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 623 13 1 9 6.0 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71459275 83001 0 None -7 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 427 4 0 4 5.7 CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181235 83001 0 None -7 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 427 4 0 4 5.7 CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
145956445 162085 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 505 6 3 5 5.2 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)O[C@H]3CCOC3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4160849 162085 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 505 6 3 5 5.2 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)O[C@H]3CCOC3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
145177795 162325 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 463 5 4 4 3.8 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)C(=O)O)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4164682 162325 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 463 5 4 4 3.8 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)C(=O)O)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
71626422 112208 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 426 4 0 6 5.0 Cc1noc2cc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)ccc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290714 112208 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 426 4 0 6 5.0 Cc1noc2cc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)ccc12 10.1016/j.ejmech.2014.05.031
119046 97537 40 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL270516 97537 40 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
71541723 87290 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 383 7 2 6 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC)cc1)CC2 10.1021/ml300277t
CHEMBL2331647 87290 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 383 7 2 6 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC)cc1)CC2 10.1021/ml300277t
134494 159745 21 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 292 0 2 2 3.8 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@H](O)CC[C@]34C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
CHEMBL410494 159745 21 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 292 0 2 2 3.8 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@H](O)CC[C@]34C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
5284305 114244 1 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assayAgonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assay
ChEMBL 364 3 3 3 4.0 C[C@H](CCO)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm500889f
CHEMBL3329940 114244 1 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assayAgonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assay
ChEMBL 364 3 3 3 4.0 C[C@H](CCO)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm500889f
137636348 155865 0 None 12 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 524 7 0 5 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4060315 155865 0 None 12 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 524 7 0 5 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
71626556 112201 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2ccoc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290707 112201 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2ccoc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
90644458 112226 0 None -1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 529 6 1 6 6.3 Cc1c(/C=C/C(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
CHEMBL3290732 112226 0 None -1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 529 6 1 6 6.3 Cc1c(/C=C/C(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
90654599 110007 0 None -12 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 571 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc(-c4ccc(C(=O)O)cc4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234870 110007 0 None -12 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 571 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc(-c4ccc(C(=O)O)cc4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
118103698 163672 0 None -12 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 724 15 5 10 2.5 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4204655 163672 0 None -12 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 724 15 5 10 2.5 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
71660821 163728 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 4 4.9 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4205214 163728 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 4 4.9 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093557 164659 0 None -3 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 477 5 1 5 4.4 O=C([C@@H]1CSCN1Cc1cc(Cl)c(CO)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4216682 164659 0 None -3 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 477 5 1 5 4.4 O=C([C@@H]1CSCN1Cc1cc(Cl)c(CO)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
71660821 163728 0 None -1 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 4 4.9 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4205214 163728 0 None -1 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 4 4.9 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
145972818 164642 0 None 3 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 734 13 6 12 1.3 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccn(Cc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)n1 10.1021/acs.jmedchem.8b00308
CHEMBL4216361 164642 0 None 3 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 734 13 6 12 1.3 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccn(Cc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)n1 10.1021/acs.jmedchem.8b00308
164617636 185350 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 530 5 1 4 7.4 COCC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4860100 185350 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 530 5 1 4 7.4 COCC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
44457471 98043 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 394 4 2 2 5.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3F 10.1021/jm7015864
CHEMBL273087 98043 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 394 4 2 2 5.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3F 10.1021/jm7015864
5059 206361 44 None -2 3 Human 5.6 pEC50 = 5.6 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 335 8 1 3 5.4 CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL8747 206361 44 None -2 3 Human 5.6 pEC50 = 5.6 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 335 8 1 3 5.4 CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
10873253 77195 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 C[C@H](CCC(=O)O)[C@H]1[C@@H](O)C[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/ml200256d
CHEMBL2062552 77195 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 C[C@H](CCC(=O)O)[C@H]1[C@@H](O)C[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/ml200256d
CHEMBL2079119 77195 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 C[C@H](CCC(=O)O)[C@H]1[C@@H](O)C[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/ml200256d
118735268 118834 0 None -2 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1398 41 2 18 10.9 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421904 118834 0 None -2 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1398 41 2 18 10.9 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
45483949 3582 35 None 2 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2020.112619
7048 3582 35 None 2 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2020.112619
CHEMBL567640 3582 35 None 2 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2020.112619
118104397 164173 0 None -15 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 750 14 6 12 2.2 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)o1 10.1021/acs.jmedchem.8b00308
CHEMBL4210547 164173 0 None -15 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 750 14 6 12 2.2 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)o1 10.1021/acs.jmedchem.8b00308
118093510 164186 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 475 4 0 4 5.7 CC1(C)SC[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4210686 164186 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 475 4 0 4 5.7 CC1(C)SC[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
71660823 164380 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 0 4 4.2 O=C([C@@H]1COCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4213036 164380 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 0 4 4.2 O=C([C@@H]1COCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118104381 164535 0 None -7 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1cccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)c1 10.1021/acs.jmedchem.8b00308
CHEMBL4215045 164535 0 None -7 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1cccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)c1 10.1021/acs.jmedchem.8b00308
46233055 200723 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1cc(Cl)ccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C 10.1016/j.bmcl.2010.01.003
CHEMBL600021 200723 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1cc(Cl)ccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C 10.1016/j.bmcl.2010.01.003
118093402 164220 0 None -1 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4211041 164220 0 None -1 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118464662 159139 0 None -22 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 687 16 0 8 7.3 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4097990 159139 0 None -22 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 687 16 0 8 7.3 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
71661223 164433 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4213705 164433 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232983 200888 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccccc1F 10.1016/j.bmcl.2010.01.003
CHEMBL601448 200888 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccccc1F 10.1016/j.bmcl.2010.01.003
46233053 201125 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C 10.1016/j.bmcl.2010.01.003
CHEMBL603107 201125 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C 10.1016/j.bmcl.2010.01.003
46232359 201376 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.9 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2010.01.003
CHEMBL604520 201376 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.9 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2010.01.003
118093511 164025 0 None 3 2 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 388 3 0 2 4.9 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4208655 164025 0 None 3 2 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 388 3 0 2 4.9 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.8b00308
118586278 159734 0 None -50 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccccc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4104779 159734 0 None -50 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccccc2)cc1OC 10.1021/acs.jmedchem.6b01873
137630592 161098 0 None - 1 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 599 13 0 6 7.4 COc1ccc(N(C)c2c(CCCC[N+](C)(C)C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4068186 161098 0 None - 1 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 599 13 0 6 7.4 COc1ccc(N(C)c2c(CCCC[N+](C)(C)C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116953 161098 0 None - 1 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 599 13 0 6 7.4 COc1ccc(N(C)c2c(CCCC[N+](C)(C)C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
44427764 93277 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 4 3 3 4.7 C[C@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O)C(=O)O 10.1021/jm070633p
CHEMBL245001 93277 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 4 3 3 4.7 C[C@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O)C(=O)O 10.1021/jm070633p
71541720 87286 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 353 6 2 5 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccccc1)CC2 10.1021/ml300277t
CHEMBL2331643 87286 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 353 6 2 5 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccccc1)CC2 10.1021/ml300277t
156705111 182930 0 None 2 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 455 5 1 6 4.9 O=C(O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4792593 182930 0 None 2 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 455 5 1 6 4.9 O=C(O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
90654593 109968 0 None -2 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 530 7 2 7 3.2 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(C(=O)O)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234580 109968 0 None -2 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 530 7 2 7 3.2 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(C(=O)O)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
71455632 82988 0 None -2 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 401 5 0 5 4.5 COc1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
CHEMBL2181223 82988 0 None -2 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 401 5 0 5 4.5 COc1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
164620346 186214 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 555 4 2 3 8.5 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4873169 186214 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 555 4 2 3 8.5 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
164626982 186306 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 5 2 3 8.3 CCCNC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4874555 186306 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 5 2 3 8.3 CCCNC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
164627955 186400 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 516 4 2 4 6.7 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)CO)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4875868 186400 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 516 4 2 4 6.7 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)CO)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
73350994 92728 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1cccs1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435942 92728 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1cccs1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
118577298 160986 0 None -18 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4086463 160986 0 None -18 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4096633 160986 0 None -18 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116110 160986 0 None -18 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
137656785 159686 0 None - 1 Mouse 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 510 5 0 5 7.3 Fc1ccc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc4c(c2)OCO4)CCC3)cc1 10.1021/acsmedchemlett.7b00116
CHEMBL4104148 159686 0 None - 1 Mouse 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 510 5 0 5 7.3 Fc1ccc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc4c(c2)OCO4)CCC3)cc1 10.1021/acsmedchemlett.7b00116
164623929 186241 0 None -31 2 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at N-terminal HA-tagged mouse TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged mouse TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 528 5 1 3 8.5 CCCC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4873587 186241 0 None -31 2 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at N-terminal HA-tagged mouse TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged mouse TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 528 5 1 3 8.5 CCCC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
247732 96149 25 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@H](O)CC[C@]34C)[C@@H]1CCC2=O 10.1021/jm7015864
CHEMBL260526 96149 25 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@H](O)CC[C@]34C)[C@@H]1CCC2=O 10.1021/jm7015864
44457504 97536 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 388 5 1 1 7.2 CC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL270494 97536 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 388 5 1 1 7.2 CC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
1452577 109937 1 None -4 2 Mouse 4.6 pEC50 = 4.6 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccccc3)C2)n1 10.1021/jm401731q
CHEMBL3234550 109937 1 None -4 2 Mouse 4.6 pEC50 = 4.6 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccccc3)C2)n1 10.1021/jm401731q
137657436 159577 0 None - 1 Mouse 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4ccc(F)cc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4102817 159577 0 None - 1 Mouse 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4ccc(F)cc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
156017547 177787 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 359 2 2 3 4.5 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
CHEMBL4643260 177787 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 359 2 2 3 4.5 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
71459273 82986 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181221 82986 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
5283906 160126 36 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 374 4 1 2 5.7 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL410893 160126 36 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 374 4 1 2 5.7 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
164626661 186594 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 614 6 3 5 7.5 CC(C)[C@@H]1CC[C@]2(NC(=O)OCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4878597 186594 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 614 6 3 5 7.5 CC(C)[C@@H]1CC[C@]2(NC(=O)OCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
90654565 109964 0 None -1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234576 109964 0 None -1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
136166955 91612 0 None 3 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 359 6 1 4 4.9 Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 10.1016/j.bmcl.2013.06.017
CHEMBL2407945 91612 0 None 3 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 359 6 1 4 4.9 Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 10.1016/j.bmcl.2013.06.017
5994 4641 88 None 1 10 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 314 1 0 2 4.7 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1021/jm7015864
CHEMBL103 4641 88 None 1 10 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 314 1 0 2 4.7 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1021/jm7015864
155534680 171948 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 431 3 2 3 4.6 C[C@H](CC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL4470499 171948 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 431 3 2 3 4.6 C[C@H](CC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
118464823 158609 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 496 6 0 4 7.6 COc1cccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)c1 10.1021/acsmedchemlett.7b00116
CHEMBL4092168 158609 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 496 6 0 4 7.6 COc1cccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)c1 10.1021/acsmedchemlett.7b00116
156011298 177386 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 401 3 2 3 5.6 CC(C)[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4638053 177386 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 401 3 2 3 5.6 CC(C)[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
71626492 112200 0 None -2 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2occc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290706 112200 0 None -2 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2occc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
145949879 162790 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 463 6 3 4 5.4 CCOC(=O)NCC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1[C@@H](CC)[C@H]3O 10.1021/acsmedchemlett.7b00318
CHEMBL4172216 162790 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 463 6 3 4 5.4 CCOC(=O)NCC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1[C@@H](CC)[C@H]3O 10.1021/acsmedchemlett.7b00318
1452520 109935 1 None 1 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncccn2)C1 10.1021/jm401731q
CHEMBL3234547 109935 1 None 1 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncccn2)C1 10.1021/jm401731q
17755103 198824 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O)C(=O)O 10.1016/j.bmc.2015.01.048
CHEMBL583611 198824 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O)C(=O)O 10.1016/j.bmc.2015.01.048
164622322 185837 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 569 4 2 3 8.8 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CCCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4867540 185837 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 569 4 2 3 8.8 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CCCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
137660218 159231 0 None 16 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 527 9 0 7 6.8 COc1ccc(SCc2cnc(SCc3c(F)cc(C#N)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4098862 159231 0 None 16 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 527 9 0 7 6.8 COc1ccc(SCc2cnc(SCc3c(F)cc(C#N)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
92810 157310 59 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 316 1 0 2 4.8 CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1021/jm7015864
CHEMBL407717 157310 59 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 316 1 0 2 4.8 CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1021/jm7015864
439763 158126 22 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL408701 158126 22 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
136166859 91609 0 None 5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407936 91609 0 None 5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
71561499 87632 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 401 4 0 6 4.2 Cc1nn(C)c(Oc2ccccc2C#N)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336217 87632 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 401 4 0 6 4.2 Cc1nn(C)c(Oc2ccccc2C#N)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
11463847 97899 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 404 3 3 3 4.3 C[C@H]([C@@H]1C[C@H]1C(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL272426 97899 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 404 3 3 3 4.3 C[C@H]([C@@H]1C[C@H]1C(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
45483949 3582 35 None -2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmcl.2014.07.026
7048 3582 35 None -2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmcl.2014.07.026
CHEMBL567640 3582 35 None -2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmcl.2014.07.026
118464802 157524 0 None - 1 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 524 5 0 5 7.3 Fc1ccc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc4c(c2)OCCO4)CCC3)cc1 10.1021/acsmedchemlett.7b00116
CHEMBL4079911 157524 0 None - 1 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 524 5 0 5 7.3 Fc1ccc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc4c(c2)OCCO4)CCC3)cc1 10.1021/acsmedchemlett.7b00116
137630926 161135 0 None -3 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 681 15 1 8 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)NCCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4086239 161135 0 None -3 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 681 15 1 8 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)NCCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4117239 161135 0 None -3 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 681 15 1 8 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)NCCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
387316 66769 48 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1016/j.ejmech.2015.09.024
CHEMBL185878 66769 48 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1016/j.ejmech.2015.09.024
118576916 157635 0 None -7 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 477 8 0 6 6.7 COc1ccc(N(C)c2cnc(SCc3c(C)cccc3C)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4081298 157635 0 None -7 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 477 8 0 6 6.7 COc1ccc(N(C)c2cnc(SCc3c(C)cccc3C)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71540077 87295 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 418 7 2 6 2.0 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)nc1)CC2 10.1021/ml300277t
CHEMBL2331652 87295 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 418 7 2 6 2.0 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)nc1)CC2 10.1021/ml300277t
90654587 109955 0 None 1 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234568 109955 0 None 1 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90654584 109952 0 None -1 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(C(F)(F)F)nc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)n2)CC1 10.1021/jm401731q
CHEMBL3234565 109952 0 None -1 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(C(F)(F)F)nc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)n2)CC1 10.1021/jm401731q
90654590 109959 0 None 1 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 502 6 1 8 2.1 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234571 109959 0 None 1 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 502 6 1 8 2.1 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
71459275 83001 0 None 7 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 427 4 0 4 5.7 CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181235 83001 0 None 7 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 427 4 0 4 5.7 CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
118093582 164121 0 None 12 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 710 15 6 10 2.1 O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4209927 164121 0 None 12 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 710 15 6 10 2.1 O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
53311869 83005 0 None -3 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL2181239 83005 0 None -3 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
71540174 87297 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 438 7 1 6 2.4 CCOc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331654 87297 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 438 7 1 6 2.4 CCOc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
53311701 113562 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 414 3 0 5 4.7 CN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL3321845 113562 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 414 3 0 5 4.7 CN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
91758806 113563 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 430 3 1 6 4.4 CN1CCN(C(=O)c2cnc(O)nc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL3321846 113563 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 430 3 1 6 4.4 CN1CCN(C(=O)c2cnc(O)nc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
46232695 200914 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 386 4 0 3 5.8 CN(C(=O)c1c(-c2ccccc2Cl)noc1C1CC1)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601638 200914 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 386 4 0 3 5.8 CN(C(=O)c1c(-c2ccccc2Cl)noc1C1CC1)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232659 201126 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 4 0 3 5.5 CCc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL603112 201126 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 4 0 3 5.5 CCc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
118103702 163700 0 None - 1 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 724 15 6 10 2.2 O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)N[C@@H](C(=O)O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4204919 163700 0 None - 1 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 724 15 6 10 2.2 O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)N[C@@H](C(=O)O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
145975890 163803 0 None 19 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 16 7 10 2.3 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4206078 163803 0 None 19 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 16 7 10 2.3 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
118103734 164650 0 None 25 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
CHEMBL4216584 164650 0 None 25 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
118104386 164692 0 None - 1 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 15 4 8 4.2 C[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](C)NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
CHEMBL4217133 164692 0 None - 1 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 15 4 8 4.2 C[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](C)NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
145967535 164793 0 None 15 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 15 6 10 2.3 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4218315 164793 0 None 15 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 15 6 10 2.3 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
90644447 112231 0 None 2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 10 1 8 5.8 CCOC(=O)CNC(=O)CCc1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290737 112231 0 None 2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 10 1 8 5.8 CCOC(=O)CNC(=O)CCc1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
71455636 83017 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 442 5 0 5 5.5 CCCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181253 83017 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 442 5 0 5 5.5 CCCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
71452079 83019 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 440 5 0 5 5.2 C=CCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181255 83019 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 440 5 0 5 5.2 C=CCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
90654596 109971 0 None -15 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 10 2 8 4.0 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(CC(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234583 109971 0 None -15 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 10 2 8 4.0 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(CC(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
71459273 82986 0 None -1 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181221 82986 0 None -1 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
71452080 83020 0 None -10 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 440 4 0 5 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181256 83020 0 None -10 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 440 4 0 5 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
164617886 184857 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 501 3 2 3 7.3 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(N)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4852436 184857 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 501 3 2 3 7.3 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(N)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
118464664 157190 0 None 2 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 478 6 0 6 5.9 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4075703 157190 0 None 2 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 478 6 0 6 5.9 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
156021144 178078 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 387 3 2 3 5.3 CC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4647613 178078 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 387 3 2 3 5.3 CC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
73350994 92728 0 None -1 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1cccs1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435942 92728 0 None -1 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1cccs1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
14774173 189881 5 None -1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 279 4 1 3 3.5 O=C(O)c1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5169385 189881 5 None -1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 279 4 1 3 3.5 O=C(O)c1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
101882290 114529 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
Activity at TGR5 in human NCI-H716 cells assessed as effect on intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayActivity at TGR5 in human NCI-H716 cells assessed as effect on intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 446 6 3 4 5.2 COc1ccc(C(=O)Nc2cccc(C(=O)O)c2)c(NC(=O)c2ccc(C(C)(C)C)cc2)c1 10.1021/jm500937v
CHEMBL3335672 114529 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
Activity at TGR5 in human NCI-H716 cells assessed as effect on intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayActivity at TGR5 in human NCI-H716 cells assessed as effect on intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 446 6 3 4 5.2 COc1ccc(C(=O)Nc2cccc(C(=O)O)c2)c(NC(=O)c2ccc(C(C)(C)C)cc2)c1 10.1021/jm500937v
9848818 97900 53 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL272427 97900 53 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
118735266 118832 0 None -2 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1178 26 2 13 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421902 118832 0 None -2 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1178 26 2 13 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
10133 910 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2011.03.004
145714624 910 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2011.03.004
4361 910 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2011.03.004
608 910 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2011.03.004
CHEMBL240597 910 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2011.03.004
DB06777 910 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2011.03.004
89707030 171768 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 391 4 3 3 3.9 C[C@H](CCC(N)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL4467588 171768 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 391 4 3 3 3.9 C[C@H](CCC(N)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
118464758 156396 0 None -95 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 560 7 0 5 8.2 COc1cc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc(Cl)c(OC)c2)CCC3)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4066466 156396 0 None -95 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 560 7 0 5 8.2 COc1cc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc(Cl)c(OC)c2)CCC3)ccc1F 10.1021/acsmedchemlett.7b00116
164618147 185365 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 599 6 2 5 7.6 CC(C)[C@@H]1CC[C@]2(C(=O)OCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4860380 185365 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 599 6 2 5 7.6 CC(C)[C@@H]1CC[C@]2(C(=O)OCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
130361936 169858 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 430 5 2 5 4.4 CO[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCc4nn[nH]n4)[C@@H]3[C@H](O)C[C@@H]2C1 10.1021/acs.jmedchem.9b00770
CHEMBL4440213 169858 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 430 5 2 5 4.4 CO[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCc4nn[nH]n4)[C@@H]3[C@H](O)C[C@@H]2C1 10.1021/acs.jmedchem.9b00770
73353940 92719 0 None 27 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 582 6 0 4 7.0 O=C(c1ccccc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435932 92719 0 None 27 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 582 6 0 4 7.0 O=C(c1ccccc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
71459274 82987 0 None -3 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1cccc(Cl)c1)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181222 82987 0 None -3 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1cccc(Cl)c1)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
71450252 83006 0 None -10 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.2 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181240 83006 0 None -10 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.2 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 10.1021/jm301071h
90654563 109962 0 None -1 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.8 CN1CCN(c2cc(N3CCCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234574 109962 0 None -1 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.8 CN1CCN(c2cc(N3CCCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
118093535 164446 0 None -5 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 10 1.4 O=C(CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4213844 164446 0 None -5 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 10 1.4 O=C(CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
118103672 164450 0 None -31 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 679 14 5 8 3.6 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4213913 164450 0 None -31 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 679 14 5 8 3.6 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
145974037 164754 0 None -15 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 725 15 7 10 1.9 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4217797 164754 0 None -15 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 725 15 7 10 1.9 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
44605616 198295 67 None 28 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/jm901434t
CHEMBL575966 198295 67 None 28 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/jm901434t
44605616 198295 67 None 28 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL575966 198295 67 None 28 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232628 200817 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 4 0 3 5.6 CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL600833 200817 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 4 0 3 5.6 CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232595 201383 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2ccccc2C(F)(F)F)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL604543 201383 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2ccccc2C(F)(F)F)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
118103700 163983 0 None 3 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 764 14 6 13 1.4 Cn1nc(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cc1OCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4208057 163983 0 None 3 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 764 14 6 13 1.4 Cn1nc(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cc1OCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118103673 164030 1 None 12 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 597 8 1 6 6.2 O=C(O)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4208726 164030 1 None 12 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 597 8 1 6 6.2 O=C(O)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
118104381 164535 0 None 7 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1cccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)c1 10.1021/acs.jmedchem.8b00308
CHEMBL4215045 164535 0 None 7 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1cccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)c1 10.1021/acs.jmedchem.8b00308
137636348 155865 0 None -12 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 524 7 0 5 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4060315 155865 0 None -12 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 524 7 0 5 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
73353943 92731 0 None 3 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 518 6 0 3 7.8 CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 10.1016/j.ejmech.2013.07.050
CHEMBL2435945 92731 0 None 3 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 518 6 0 3 7.8 CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 10.1016/j.ejmech.2013.07.050
64980 205467 8 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 458 2 2 3 6.1 CC(=O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL80460 205467 8 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 458 2 2 3 6.1 CC(=O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
118464758 156396 0 None 95 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 560 7 0 5 8.2 COc1cc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc(Cl)c(OC)c2)CCC3)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4066466 156396 0 None 95 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 560 7 0 5 8.2 COc1cc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc(Cl)c(OC)c2)CCC3)ccc1F 10.1021/acsmedchemlett.7b00116
71561617 87638 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1ccncc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336225 87638 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1ccncc1 10.1016/j.bmcl.2012.12.076
71453902 83009 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 373 4 0 4 4.9 CN(C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl)c1ccccc1 10.1021/jm301071h
CHEMBL2181243 83009 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 373 4 0 4 4.9 CN(C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl)c1ccccc1 10.1021/jm301071h
44605617 198319 1 None 5 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/ml300277t
CHEMBL576138 198319 1 None 5 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/ml300277t
118093484 163523 0 None -31 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 617 8 1 8 5.6 Cn1c(C(=O)O)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4202656 163523 0 None -31 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 617 8 1 8 5.6 Cn1c(C(=O)O)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
71660822 164765 0 None 5 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 461 4 0 4 4.9 O=C([C@@H]1CSCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4217961 164765 0 None 5 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 461 4 0 4 4.9 O=C([C@@H]1CSCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232485 200615 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 410 4 0 4 5.5 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(OC(F)(F)F)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL599347 200615 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 410 4 0 4 5.5 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(OC(F)(F)F)cc1 10.1016/j.bmcl.2010.01.003
46232596 201065 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2cccc(C(F)(F)F)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL602691 201065 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2cccc(C(F)(F)F)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232486 201537 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 351 3 0 4 4.5 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C#N)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL605356 201537 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 351 3 0 4 4.5 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C#N)cc1 10.1016/j.bmcl.2010.01.003
46232656 202101 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 5 0 3 6.0 CCCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL608867 202101 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 5 0 3 6.0 CCCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
71660823 164380 0 None -1 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 0 4 4.2 O=C([C@@H]1COCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4213036 164380 0 None -1 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 0 4 4.2 O=C([C@@H]1COCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093420 164545 0 None -1 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
CHEMBL4215113 164545 0 None -1 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
5283820 97958 65 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL272621 97958 65 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
46232657 200819 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 386 4 0 3 5.8 Cc1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C1CC1 10.1016/j.bmcl.2010.01.003
CHEMBL600835 200819 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 386 4 0 3 5.8 Cc1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C1CC1 10.1016/j.bmcl.2010.01.003
46232698 200850 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 372 2 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N1CCc2cc(Cl)ccc21 10.1016/j.bmcl.2010.01.003
CHEMBL601218 200850 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 372 2 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N1CCc2cc(Cl)ccc21 10.1016/j.bmcl.2010.01.003
723048 200924 20 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 346 3 1 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)Nc1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601671 200924 20 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 346 3 1 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)Nc1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
44626599 197730 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 573 4 1 4 8.9 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\OC(=O)c6ccccc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL571478 197730 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 573 4 1 4 8.9 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\OC(=O)c6ccccc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
71561367 87627 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 412 4 0 5 4.6 Cc1nn(C)c(Oc2cccc(F)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336212 87627 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 412 4 0 5 4.6 Cc1nn(C)c(Oc2cccc(F)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
73353941 92720 0 None 28 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 572 6 0 5 6.6 O=C(c1ccco1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435933 92720 0 None 28 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 572 6 0 5 6.6 O=C(c1ccco1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
73357026 92727 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 504 6 0 3 7.2 O=C(c1ccoc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435941 92727 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 504 6 0 3 7.2 O=C(c1ccoc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
90654570 109938 0 None 2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 342 5 1 4 2.5 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(F)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234551 109938 0 None 2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 342 5 1 4 2.5 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(F)cc3)C2)n1 10.1021/jm401731q
441302 97861 67 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@H](O)CC[C@@]43C)[C@@H]1CCC2=O 10.1021/jm7015864
CHEMBL272195 97861 67 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@H](O)CC[C@@]43C)[C@@H]1CCC2=O 10.1021/jm7015864
118464804 156543 0 None 4 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 568 9 1 6 6.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(CCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4068168 156543 0 None 4 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 568 9 1 6 6.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(CCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
24969872 17669 0 None 10 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1021/ml300277t
CHEMBL1258423 17669 0 None 10 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1021/ml300277t
126700765 156505 0 None -8 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 9 0 6 6.2 COc1ccc(CN(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4067717 156505 0 None -8 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 9 0 6 6.2 COc1ccc(CN(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
90654571 109939 0 None 2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 402 5 1 4 3.1 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Br)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234552 109939 0 None 2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 402 5 1 4 3.1 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Br)cc3)C2)n1 10.1021/jm401731q
71561754 87644 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 432 6 0 5 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C(C)C 10.1016/j.bmcl.2012.12.076
CHEMBL2336232 87644 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 432 6 0 5 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C(C)C 10.1016/j.bmcl.2012.12.076
155339374 181866 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 569 11 7 8 1.6 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1039/d0md00425a
CHEMBL4778769 181866 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 569 11 7 8 1.6 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1039/d0md00425a
118464724 159465 0 None 61 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 528 7 0 6 6.8 COc1ccc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4101442 159465 0 None 61 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 528 7 0 6 6.8 COc1ccc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
439763 158126 22 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation in presence of 3-isobutyl-1-methylxanthine after 20 minsAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation in presence of 3-isobutyl-1-methylxanthine after 20 mins
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acs.jmedchem.9b00770
CHEMBL408701 158126 22 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation in presence of 3-isobutyl-1-methylxanthine after 20 minsAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation in presence of 3-isobutyl-1-methylxanthine after 20 mins
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acs.jmedchem.9b00770
71626834 118830 0 None 2 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 10 2 6 5.3 O=C(O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421900 118830 0 None 2 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 10 2 6 5.3 O=C(O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
10133 910 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
145714624 910 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
4361 910 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
608 910 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
CHEMBL240597 910 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
DB06777 910 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
10133 910 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.6b01126
145714624 910 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.6b01126
4361 910 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.6b01126
608 910 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.6b01126
CHEMBL240597 910 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.6b01126
DB06777 910 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.6b01126
44627310 198780 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 474 3 3 3 6.1 CC(CO)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL583203 198780 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 474 3 3 3 6.1 CC(CO)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
5881 206850 78 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 288 0 1 2 3.9 C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CCC2=O 10.1021/jm7015864
CHEMBL90593 206850 78 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 288 0 1 2 3.9 C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CCC2=O 10.1021/jm7015864
71559936 87623 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 394 4 0 5 4.4 Cc1nn(C)c(Oc2ccccc2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336208 87623 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 394 4 0 5 4.4 Cc1nn(C)c(Oc2ccccc2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
126673445 157548 0 None -47 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 8 0 6 6.7 COc1ccc(N(C)c2c(C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4080290 157548 0 None -47 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 8 0 6 6.7 COc1ccc(N(C)c2c(C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
155669594 183134 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 394 4 0 4 3.8 O=C(c1cncn1Cc1ccc(F)cc1F)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4795121 183134 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 394 4 0 4 3.8 O=C(c1cncn1Cc1ccc(F)cc1F)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
12310288 158726 43 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL409348 158726 43 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
90644457 112228 0 None -2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 8 2 8 4.9 Cc1c(/C=C/C(=O)NCC(=O)O)oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
CHEMBL3290734 112228 0 None -2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 8 2 8 4.9 Cc1c(/C=C/C(=O)NCC(=O)O)oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
118464680 158660 0 None -46 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 526 7 0 5 7.6 COc1ccc([C@@H]2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4092785 158660 0 None -46 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 526 7 0 5 7.6 COc1ccc([C@@H]2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
45483949 3582 35 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/jm901390p
7048 3582 35 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/jm901390p
CHEMBL567640 3582 35 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/jm901390p
156705120 181873 0 None -41 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 503 6 0 7 5.6 O=C(OCCl)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4778884 181873 0 None -41 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 503 6 0 7 5.6 O=C(OCCl)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
71559937 87624 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 410 4 0 5 4.9 Cc1nn(C)c(Oc2cccc(Cl)c2)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336209 87624 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 410 4 0 5 4.9 Cc1nn(C)c(Oc2cccc(Cl)c2)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
73352466 92711 0 None 4 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 453 5 1 3 6.3 N#CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435924 92711 0 None 4 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 453 5 1 3 6.3 N#CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
90644448 112230 0 None 2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 1 6 6.2 Cc1c(CCC(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
CHEMBL3290736 112230 0 None 2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 1 6 6.2 Cc1c(CCC(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
118576935 157950 0 None -43 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 485 8 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4084668 157950 0 None -43 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 485 8 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
118576958 158405 0 None -17 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 519 8 0 6 7.0 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)c(Cl)c2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4090147 158405 0 None -17 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 519 8 0 6 7.0 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)c(Cl)c2)cc1OC 10.1021/acs.jmedchem.6b01873
89501664 161451 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 566 9 0 4 8.7 CC(C)(c1ccc(Cl)c(Cl)c1)c1cnc(SCCOCc2c(F)cccc2Cl)n1-c1ccc(F)cc1 10.1016/j.bmcl.2018.04.011
CHEMBL4127444 161451 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 566 9 0 4 8.7 CC(C)(c1ccc(Cl)c(Cl)c1)c1cnc(SCCOCc2c(F)cccc2Cl)n1-c1ccc(F)cc1 10.1016/j.bmcl.2018.04.011
73355480 92723 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 514 6 0 2 7.6 O=C(c1ccccc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435937 92723 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 514 6 0 2 7.6 O=C(c1ccccc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
1452520 109935 1 None -1 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncccn2)C1 10.1021/jm401731q
CHEMBL3234547 109935 1 None -1 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncccn2)C1 10.1021/jm401731q
118464718 158250 0 None -36 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 568 8 1 6 6.9 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)O)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4088541 158250 0 None -36 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 568 8 1 6 6.9 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)O)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
155669596 180669 0 None -1 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 358 4 0 4 3.6 O=C(c1cncn1Cc1ccccc1)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4755237 180669 0 None -1 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 358 4 0 4 3.6 O=C(c1cncn1Cc1ccccc1)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
71626832 118825 0 None 2 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 511 7 1 5 5.8 O=C(O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421894 118825 0 None 2 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 511 7 1 5 5.8 O=C(O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
118464622 158871 0 None -26 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 548 6 0 4 8.4 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4F)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4095058 158871 0 None -26 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 548 6 0 4 8.4 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4F)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
71561614 87631 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.3 Cc1nn(C)c(Oc2ccccc2C(F)(F)F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336216 87631 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.3 Cc1nn(C)c(Oc2ccccc2C(F)(F)F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
90654567 109966 0 None - 1 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 473 6 1 7 2.1 CN1CCN(c2cc(N3CC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234578 109966 0 None - 1 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 473 6 1 7 2.1 CN1CCN(c2cc(N3CC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
44427760 93226 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O)C(=O)O 10.1021/jm070633p
CHEMBL244783 93226 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O)C(=O)O 10.1021/jm070633p
17755103 198824 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O)C(=O)O 10.1021/jm901390p
CHEMBL583611 198824 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O)C(=O)O 10.1021/jm901390p
136166852 91634 0 None 2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2408107 91634 0 None 2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
44457475 96195 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 509 9 2 3 6.5 CCC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL260737 96195 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 509 9 2 3 6.5 CCC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@H]12 10.1021/jm7015864
45483949 3582 35 None 2 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2013.07.050
7048 3582 35 None 2 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2013.07.050
CHEMBL567640 3582 35 None 2 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2013.07.050
31401 48109 80 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL1551 48109 80 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
45485277 197733 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 553 4 1 4 8.7 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@](C)(CC[C@@H]4[C@@]5(C)CC/C(=N\OC(=O)C(C)C)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL571493 197733 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 553 4 1 4 8.7 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@](C)(CC[C@@H]4[C@@]5(C)CC/C(=N\OC(=O)C(C)C)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
118586279 155852 0 None 2 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 535 8 0 6 7.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(C(F)(F)F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4060122 155852 0 None 2 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 535 8 0 6 7.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(C(F)(F)F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
114611 97672 43 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL271208 97672 43 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
137653533 158763 0 None -48 2 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 702 16 5 9 5.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NC(CCCNC(=N)N)C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4094009 158763 0 None -48 2 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 702 16 5 9 5.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NC(CCCNC(=N)N)C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
155669593 183222 0 None -31 2 Mouse 5.4 pEC50 = 5.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 392 4 0 4 4.2 O=C(c1cncn1Cc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4796107 183222 0 None -31 2 Mouse 5.4 pEC50 = 5.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 392 4 0 4 4.2 O=C(c1cncn1Cc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
164612607 185410 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 3 4 6.8 C[C@@H](O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4861151 185410 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 3 4 6.8 C[C@@H](O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
73347897 92712 0 None -6 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 435 5 1 3 6.1 N#CC(NCc1cnccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435925 92712 0 None -6 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 435 5 1 3 6.1 N#CC(NCc1cnccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
71455635 83007 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 416 5 0 5 4.9 CN(C)c1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl 10.1021/jm301071h
CHEMBL2181241 83007 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 416 5 0 5 4.9 CN(C)c1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl 10.1021/jm301071h
118464811 156790 0 None -5 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)ccc(OCCOCCOCCN(C)C)c4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4070895 156790 0 None -5 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)ccc(OCCOCCOCCN(C)C)c4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
5880 206112 40 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@H](O)CC[C@]34C)[C@@H]1CCC2=O 10.1021/jm7015864
CHEMBL85799 206112 40 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@H](O)CC[C@]34C)[C@@H]1CCC2=O 10.1021/jm7015864
71541721 87287 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 367 6 2 5 1.8 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C)cc1)CC2 10.1021/ml300277t
CHEMBL2331644 87287 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 367 6 2 5 1.8 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C)cc1)CC2 10.1021/ml300277t
90644459 112213 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 6 0 7 6.4 CCOC(=O)c1oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290719 112213 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 6 0 7 6.4 CCOC(=O)c1oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2c1C 10.1016/j.ejmech.2014.05.031
90654592 109961 0 None -2 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 517 7 1 9 1.9 CCN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4cnc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234573 109961 0 None -2 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 517 7 1 9 1.9 CCN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4cnc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90644453 112215 0 None -7 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 0 7 6.0 CCOC(=O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290721 112215 0 None -7 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 0 7 6.0 CCOC(=O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
90654574 109942 0 None -4 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 376 5 1 4 3.2 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)ncc1F 10.1021/jm401731q
CHEMBL3234555 109942 0 None -4 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 376 5 1 4 3.2 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)ncc1F 10.1021/jm401731q
137661039 159489 0 None 21 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 653 13 2 9 5.5 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4101738 159489 0 None 21 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 653 13 2 9 5.5 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
164614522 184895 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 598 6 3 4 7.2 CC(C)[C@@H]1CC[C@]2(C(=O)NCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4852971 184895 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 598 6 3 4 7.2 CC(C)[C@@H]1CC[C@]2(C(=O)NCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
71626765 118824 0 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 539 8 0 6 6.3 CCOC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421893 118824 0 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 539 8 0 6 6.3 CCOC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
118464620 158914 0 None - 1 Mouse 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 542 7 0 5 8.1 COc1ccc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc(Cl)c(OC)c2)CCC3)cc1 10.1021/acsmedchemlett.7b00116
CHEMBL4095497 158914 0 None - 1 Mouse 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 542 7 0 5 8.1 COc1ccc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc(Cl)c(OC)c2)CCC3)cc1 10.1021/acsmedchemlett.7b00116
71561370 87630 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 424 4 0 5 5.2 Cc1ccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c(Cl)c1 10.1016/j.bmcl.2012.12.076
CHEMBL2336215 87630 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 424 4 0 5 5.2 Cc1ccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c(Cl)c1 10.1016/j.bmcl.2012.12.076
73349425 92710 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 456 6 1 2 7.2 CCC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435922 92710 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 456 6 1 2 7.2 CCC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
1012 25 86 None -22387 4 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm7015864
1013 25 86 None -22387 4 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm7015864
1057 25 86 None -22387 4 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm7015864
5757 25 86 None -22387 4 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm7015864
CHEMBL135 25 86 None -22387 4 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm7015864
DB00783 25 86 None -22387 4 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm7015864
71453905 83014 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 3 0 4 5.2 O=C(c1ncncc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
CHEMBL2181250 83014 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 3 0 4 5.2 O=C(c1ncncc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
162665892 182325 0 None -16 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 537 6 0 7 6.0 O=C(OCC(F)(F)F)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4784355 182325 0 None -16 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 537 6 0 7 6.0 O=C(OCC(F)(F)F)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
12544 48178 32 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL1552 48178 32 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
77845059 112214 0 None -22 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 517 6 0 7 6.1 CCOC(=O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290720 112214 0 None -22 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 517 6 0 7 6.1 CCOC(=O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
118093582 164121 0 None -12 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 710 15 6 10 2.1 O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4209927 164121 0 None -12 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 710 15 6 10 2.1 O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
145971348 164570 0 None 1 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 481 4 0 4 5.2 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1C(F)(F)F)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4215354 164570 0 None 1 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 481 4 0 4 5.2 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1C(F)(F)F)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232629 200818 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 4 0 3 6.0 Cc1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C(C)C 10.1016/j.bmcl.2010.01.003
CHEMBL600834 200818 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 4 0 3 6.0 Cc1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C(C)C 10.1016/j.bmcl.2010.01.003
118103669 164197 0 None - 1 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 1047 28 13 18 -2.1 O=C(NCCCN(CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4210783 164197 0 None - 1 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 1047 28 13 18 -2.1 O=C(NCCCN(CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
74766512 157447 0 None -3 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 699 17 0 9 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4079040 157447 0 None -3 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 699 17 0 9 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
71561619 87640 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 430 4 0 5 5.2 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336227 87640 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 430 4 0 5 5.2 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
71541719 87289 1 None -194 3 Rat 5.4 pEC50 = 5.4 Functional
Agonist activity at rat TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at rat TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
CHEMBL2331646 87289 1 None -194 3 Rat 5.4 pEC50 = 5.4 Functional
Agonist activity at rat TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at rat TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
118464639 158161 0 None - 1 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 541 7 0 6 7.5 COc1cc(C2CCCc3nc(SCc4c(F)cccc4[N+](=O)[O-])n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4087370 158161 0 None - 1 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 541 7 0 6 7.5 COc1cc(C2CCCc3nc(SCc4c(F)cccc4[N+](=O)[O-])n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
118103673 164030 1 None -12 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 597 8 1 6 6.2 O=C(O)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4208726 164030 1 None -12 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 597 8 1 6 6.2 O=C(O)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
118103718 164521 0 None 1 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 9 1.4 O=C(CCc1cc(Cl)c(CN2C[C@@H](F)C[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4214838 164521 0 None 1 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 9 1.4 O=C(CCc1cc(Cl)c(CN2C[C@@H](F)C[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
46232982 201422 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL604751 201422 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
46233023 201649 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C 10.1016/j.bmcl.2010.01.003
CHEMBL605986 201649 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C 10.1016/j.bmcl.2010.01.003
118093493 163572 0 None -3 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 664 13 6 9 1.5 O=C(CCc1cc(Cl)c(CN2CCC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4203191 163572 0 None -3 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 664 13 6 9 1.5 O=C(CCc1cc(Cl)c(CN2CCC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
118093510 164186 0 None -1 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 475 4 0 4 5.7 CC1(C)SC[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4210686 164186 0 None -1 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 475 4 0 4 5.7 CC1(C)SC[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
118093506 164722 0 None 1 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4217450 164722 0 None 1 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
5283932 97666 23 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 390 4 2 3 4.7 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CCC(=O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL271172 97666 23 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 390 4 2 3 4.7 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CCC(=O)C[C@H]1C[C@H]3O 10.1021/jm7015864
71660856 164206 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 406 3 0 3 5.1 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4210879 164206 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 406 3 0 3 5.1 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 10.1021/acs.jmedchem.8b00308
46232487 200409 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 369 4 0 4 4.6 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL598120 200409 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 369 4 0 4 4.6 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2010.01.003
749179 202544 17 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 326 3 0 3 4.6 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccccc1 10.1016/j.bmcl.2010.01.003
CHEMBL611676 202544 17 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 326 3 0 3 4.6 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccccc1 10.1016/j.bmcl.2010.01.003
90654585 109953 0 None 2 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 465 6 1 7 2.1 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)nc(N2CCN(C)CC2)c1F 10.1021/jm401731q
CHEMBL3234566 109953 0 None 2 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 465 6 1 7 2.1 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)nc(N2CCN(C)CC2)c1F 10.1021/jm401731q
90654566 109965 0 None -1 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 473 6 1 7 2.1 CN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234577 109965 0 None -1 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 473 6 1 7 2.1 CN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90654564 109963 0 None 1 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234575 109963 0 None 1 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90654568 109967 0 None 4 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 7 1 8 1.8 CCN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)nc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234579 109967 0 None 4 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 7 1 8 1.8 CCN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)nc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90654594 109969 0 None 3 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 544 7 2 7 3.6 CC1(C(=O)O)CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234581 109969 0 None 3 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 544 7 2 7 3.6 CC1(C(=O)O)CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
118576999 159705 0 None 17 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 566 9 0 7 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CCN(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4104359 159705 0 None 17 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 566 9 0 7 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CCN(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
162657867 181029 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 390 5 0 5 3.5 COc1ccc(N2CCN(C(=O)c3cncn3[C@H](C)c3ccccc3)CC2)cc1 10.1016/j.bmc.2020.115972
CHEMBL4759282 181029 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 390 5 0 5 3.5 COc1ccc(N2CCN(C(=O)c3cncn3[C@H](C)c3ccccc3)CC2)cc1 10.1016/j.bmc.2020.115972
156705119 183114 0 None 29 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 499 7 0 8 5.0 COCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4794753 183114 0 None 29 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 499 7 0 8 5.0 COCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
71540075 87293 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 435 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331650 87293 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 435 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC(F)(F)F)cc1)CC2 10.1021/ml300277t
118586284 156547 0 None 9 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 503 8 0 6 6.5 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2F)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4068227 156547 0 None 9 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 503 8 0 6 6.5 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2F)cc1OC 10.1021/acs.jmedchem.6b01873
71626557 112196 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1cccc2ncccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290702 112196 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1cccc2ncccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
126700765 156505 0 None 8 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 9 0 6 6.2 COc1ccc(CN(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4067717 156505 0 None 8 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 9 0 6 6.2 COc1ccc(CN(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
101886309 114911 26 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assayAgonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.6 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCO)[C@@H]2[C@@H]1O 10.1021/jm501273r
CHEMBL3342086 114911 26 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assayAgonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.6 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCO)[C@@H]2[C@@H]1O 10.1021/jm501273r
91668293 136381 10 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 (unknown origin) assessed as cAMP levelAgonist activity at TGR5 (unknown origin) assessed as cAMP level
ChEMBL 576 9 4 3 7.1 C[C@H](CCC(=O)N[C@H](CC(=O)O)Cc1c[nH]c2ccccc12)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.ejmech.2015.08.048
CHEMBL3735125 136381 10 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 (unknown origin) assessed as cAMP levelAgonist activity at TGR5 (unknown origin) assessed as cAMP level
ChEMBL 576 9 4 3 7.1 C[C@H](CCC(=O)N[C@H](CC(=O)O)Cc1c[nH]c2ccccc12)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.ejmech.2015.08.048
73353938 92706 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 512 5 1 3 6.1 O=S(=O)(NCc1c(-c2ccccc2F)ccnc1Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435915 92706 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 512 5 1 3 6.1 O=S(=O)(NCc1c(-c2ccccc2F)ccnc1Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
73353942 92725 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 515 6 0 3 7.0 O=C(c1ccncc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435939 92725 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 515 6 0 3 7.0 O=C(c1ccncc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
118709773 113561 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 446 4 1 6 5.4 CSc1ncc(C(=O)N2CCNc3ccccc32)c(Oc2cc(Cl)ccc2Cl)n1 10.1016/j.bmcl.2014.07.026
CHEMBL3321844 113561 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 446 4 1 6 5.4 CSc1ncc(C(=O)N2CCNc3ccccc32)c(Oc2cc(Cl)ccc2Cl)n1 10.1016/j.bmcl.2014.07.026
71626490 112195 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 421 4 0 4 5.7 O=C(c1cnccc1Oc1ccc2ccccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290701 112195 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 421 4 0 4 5.7 O=C(c1cnccc1Oc1ccc2ccccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
118576916 157635 0 None 7 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 477 8 0 6 6.7 COc1ccc(N(C)c2cnc(SCc3c(C)cccc3C)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4081298 157635 0 None 7 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 477 8 0 6 6.7 COc1ccc(N(C)c2cnc(SCc3c(C)cccc3C)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
162656549 180954 0 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@@H]2[C@H]([C@@H]3CC[C@H]([C@H](C)CCC(=O)O)[C@@]3(C)C[C@H]2O)[C@@H]1O 10.1021/acs.jmedchem.6b01126
CHEMBL4758363 180954 0 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@@H]2[C@H]([C@@H]3CC[C@H]([C@H](C)CCC(=O)O)[C@@]3(C)C[C@H]2O)[C@@H]1O 10.1021/acs.jmedchem.6b01126
44627314 197746 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 510 4 2 2 8.4 C=C(C)C[C@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
CHEMBL571592 197746 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 510 4 2 2 8.4 C=C(C)C[C@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
145955411 162398 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 474 6 4 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)NC3CC3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4165830 162398 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 474 6 4 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)NC3CC3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
137651232 157368 0 None -20 2 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 570 10 1 9 6.1 COc1ccc(SCc2cnc(SCc3c(F)cc(-c4nn[nH]n4)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4077972 157368 0 None -20 2 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 570 10 1 9 6.1 COc1ccc(SCc2cnc(SCc3c(F)cc(-c4nn[nH]n4)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
71540077 87295 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 418 7 2 6 2.0 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)nc1)CC2 10.1021/ml300277t
CHEMBL2331652 87295 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 418 7 2 6 2.0 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)nc1)CC2 10.1021/ml300277t
71540175 87298 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 434 6 1 5 2.9 NC(=O)c1nc(C2CC2)nc2c1CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331655 87298 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 434 6 1 5 2.9 NC(=O)c1nc(C2CC2)nc2c1CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71626556 112201 0 None -1 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2ccoc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290707 112201 0 None -1 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2ccoc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
90654572 109940 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ncccn3)C2)cc1 10.1021/jm401731q
CHEMBL3234553 109940 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ncccn3)C2)cc1 10.1021/jm401731q
118586282 159555 0 None -23 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 486 8 0 7 5.8 COc1ccc(N(C)c2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4102610 159555 0 None -23 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 486 8 0 7 5.8 COc1ccc(N(C)c2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
118464815 159516 0 None -6 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 528 6 0 4 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4102107 159516 0 None -6 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 528 6 0 4 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
44427763 96973 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 422 4 4 4 3.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O)C(=O)O 10.1021/jm070633p
CHEMBL266356 96973 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 422 4 4 4 3.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O)C(=O)O 10.1021/jm070633p
11069533 98042 35 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 406 4 2 4 4.6 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL273086 98042 35 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 406 4 2 4 4.6 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
118725000 117060 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1021/jm7015864
CHEMBL3391714 117060 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1021/jm7015864
156705112 182864 0 None -15 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 483 6 0 7 5.4 CCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4791709 182864 0 None -15 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 483 6 0 7 5.4 CCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
118577011 156986 0 None 20 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 489 7 0 5 7.0 COc1cc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)ccc1Cl 10.1021/acs.jmedchem.6b01873
CHEMBL4073081 156986 0 None 20 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 489 7 0 5 7.0 COc1cc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)ccc1Cl 10.1021/acs.jmedchem.6b01873
91972025 155958 0 None -43 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 540 7 0 5 7.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4061329 155958 0 None -43 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 540 7 0 5 7.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
21121407 156635 1 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 442 5 3 4 4.3 C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL406923 156635 1 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 442 5 3 4 4.3 C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
73352462 92633 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 486 6 1 4 5.9 COC(=O)C(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435835 92633 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 486 6 1 4 5.9 COC(=O)C(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
90654586 109954 0 None -2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1nc(N2CCN(C)CC2)cc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234567 109954 0 None -2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1nc(N2CCN(C)CC2)cc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
10635 98712 49 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
CHEMBL27769 98712 49 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
137661958 159524 0 None - 1 Mouse 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 562 10 1 7 5.6 COc1ccc(SCc2cnc([S+]([O-])Cc3c(F)cc(C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4102235 159524 0 None - 1 Mouse 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 562 10 1 7 5.6 COc1ccc(SCc2cnc([S+]([O-])Cc3c(F)cc(C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
164620529 185692 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 551 5 2 4 6.7 CNS(=O)(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4865346 185692 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 551 5 2 4 6.7 CNS(=O)(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
71461053 82984 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 4 0 3 6.1 CN(C(=O)c1cnccc1Oc1cc(Cl)ccc1Cl)c1ccccc1Cl 10.1021/jm301071h
CHEMBL2181219 82984 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 4 0 3 6.1 CN(C(=O)c1cnccc1Oc1cc(Cl)ccc1Cl)c1ccccc1Cl 10.1021/jm301071h
164610027 184731 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 571 3 1 4 7.6 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)N6CCOCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4850654 184731 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 571 3 1 4 7.6 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)N6CCOCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
44605617 198319 1 None 5 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL576138 198319 1 None 5 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1016/j.bmcl.2012.12.076
73357023 92708 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 428 5 1 2 6.2 Fc1ccccc1-c1ccncc1CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435919 92708 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 428 5 1 2 6.2 Fc1ccccc1-c1ccncc1CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
156014273 177218 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 435 3 2 3 6.1 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@@](O)(c4ccccc4)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
CHEMBL4635505 177218 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 435 3 2 3 6.1 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@@](O)(c4ccccc4)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
56602333 91607 0 None 11 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407934 91607 0 None 11 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
118464806 159057 0 None 34 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4097059 159057 0 None 34 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
73350993 92716 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 495 7 0 3 7.4 CCCN(Cc1cnccc1-c1ccccc1F)C(C#N)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435929 92716 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 495 7 0 3 7.4 CCCN(Cc1cnccc1-c1ccccc1F)C(C#N)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
71561615 87636 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@H]1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336223 87636 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@H]1c1cccnc1 10.1016/j.bmcl.2012.12.076
71452075 82985 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 371 4 0 4 4.5 O=C(c1cnccc1Oc1ccccc1)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181220 82985 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 371 4 0 4 4.5 O=C(c1cnccc1Oc1ccccc1)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
46232736 201308 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/ml300277t
CHEMBL604131 201308 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/ml300277t
118586284 156547 0 None -9 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 503 8 0 6 6.5 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2F)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4068227 156547 0 None -9 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 503 8 0 6 6.5 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2F)cc1OC 10.1021/acs.jmedchem.6b01873
73355481 92726 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 504 6 0 3 7.2 O=C(c1ccco1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435940 92726 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 504 6 0 3 7.2 O=C(c1ccco1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
66740913 158655 0 None -22 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 471 8 0 6 5.6 COc1ccc(Cc2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4092629 158655 0 None -22 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 471 8 0 6 5.6 COc1ccc(Cc2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
122844 167938 58 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 454 2 1 2 7.3 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL431525 167938 58 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 454 2 1 2 7.3 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
192254 17107 29 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 3 3 3 4.1 C[C@H](CC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL1254990 17107 29 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 3 3 3 4.1 C[C@H](CC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
440071 97535 10 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 563 9 3 6 4.3 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](OS(=O)(=O)O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL270493 97535 10 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 563 9 3 6 4.3 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](OS(=O)(=O)O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
9910920 197138 1 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/jm901390p
CHEMBL567835 197138 1 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/jm901390p
53311618 83015 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 399 3 0 4 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL2181251 83015 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 399 3 0 4 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1016/j.bmcl.2014.07.026
71540074 87292 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 453 7 2 6 3.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(SC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331649 87292 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 453 7 2 6 3.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(SC(F)(F)F)cc1)CC2 10.1021/ml300277t
90654591 109960 0 None 1 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 6 2 8 1.7 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cn1 10.1021/jm401731q
CHEMBL3234572 109960 0 None 1 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 6 2 8 1.7 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cn1 10.1021/jm401731q
118464629 156255 0 None - 1 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1cc(C2CCCc3nc(SCc4c(F)cccc4OC)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4064931 156255 0 None - 1 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1cc(C2CCCc3nc(SCc4c(F)cccc4OC)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
11069533 98042 35 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 406 4 2 4 4.6 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL273086 98042 35 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 406 4 2 4 4.6 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
71457417 82983 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 401 5 0 4 5.6 CCN(C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl)c1ccccc1C 10.1021/jm301071h
CHEMBL2181218 82983 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 401 5 0 4 5.6 CCN(C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl)c1ccccc1C 10.1021/jm301071h
5283821 97957 21 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL272620 97957 21 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
90654579 109947 0 None -5 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)c1 10.1021/jm401731q
CHEMBL3234560 109947 0 None -5 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)c1 10.1021/jm401731q
53311781 82999 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 398 3 0 3 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
CHEMBL2181233 82999 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 398 3 0 3 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
71561756 87645 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 446 6 0 5 5.6 Cc1ccc(CN(C(=O)c2c(C)nn(C)c2Oc2cccc(Cl)c2Cl)C(C)C)cn1 10.1016/j.bmcl.2012.12.076
CHEMBL2336233 87645 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 446 6 0 5 5.6 Cc1ccc(CN(C(=O)c2c(C)nn(C)c2Oc2cccc(Cl)c2Cl)C(C)C)cn1 10.1016/j.bmcl.2012.12.076
155339365 181008 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 507 11 2 5 4.8 COCCOCCNC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3OC 10.1039/d0md00425a
CHEMBL4759021 181008 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 507 11 2 5 4.8 COCCOCCNC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3OC 10.1039/d0md00425a
118464755 158505 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 544 6 0 4 8.5 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(C)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4091129 158505 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 544 6 0 4 8.5 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(C)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
71561500 87633 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 406 5 0 6 4.3 COc1cccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c1 10.1016/j.bmcl.2012.12.076
CHEMBL2336218 87633 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 406 5 0 6 4.3 COc1cccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c1 10.1016/j.bmcl.2012.12.076
137660218 159231 0 None -16 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 527 9 0 7 6.8 COc1ccc(SCc2cnc(SCc3c(F)cc(C#N)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4098862 159231 0 None -16 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 527 9 0 7 6.8 COc1ccc(SCc2cnc(SCc3c(F)cc(C#N)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
6675 85127 40 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 515 7 5 6 2.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL224867 85127 40 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 515 7 5 6 2.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
164611776 186215 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 3 4 6.8 C[C@H](O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4873170 186215 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 3 4 6.8 C[C@H](O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
118709777 113565 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 403 3 1 3 4.2 CN1CCN(C(=O)C2(C(=O)Nc3cc(Cl)ccc3Cl)CC2)c2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL3321850 113565 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 403 3 1 3 4.2 CN1CCN(C(=O)C2(C(=O)Nc3cc(Cl)ccc3Cl)CC2)c2ccccc21 10.1016/j.bmcl.2014.07.026
118586278 159734 0 None 50 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccccc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4104779 159734 0 None 50 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccccc2)cc1OC 10.1021/acs.jmedchem.6b01873
90644453 112215 0 None 7 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 0 7 6.0 CCOC(=O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290721 112215 0 None 7 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 0 7 6.0 CCOC(=O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71718878 87650 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1016/j.bmcl.2012.12.076
CHEMBL2336238 87650 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1016/j.bmcl.2012.12.076
71718878 87650 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1039/C2MD20174G
CHEMBL2336238 87650 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1039/C2MD20174G
71626488 112207 0 None -3 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 426 4 0 6 5.0 Cc1noc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290713 112207 0 None -3 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 426 4 0 6 5.0 Cc1noc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
155339372 173070 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 444 5 1 5 5.6 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCc3nnc(C)o3)[C@@H]21 10.1021/acs.jmedchem.9b00770
CHEMBL4519596 173070 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 444 5 1 5 5.6 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCc3nnc(C)o3)[C@@H]21 10.1021/acs.jmedchem.9b00770
118464803 155784 0 None 15 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 525 7 0 6 6.6 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cncc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4059508 155784 0 None 15 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 525 7 0 6 6.6 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cncc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
71661185 163810 0 None 1 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4206153 163810 0 None 1 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093562 163887 0 None -5 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 547 9 1 5 5.7 O=C(O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4207005 163887 0 None -5 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 547 9 1 5 5.7 O=C(O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
71661185 163810 0 None -1 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4206153 163810 0 None -1 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
14650340 67184 1 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 307 7 0 3 5.0 CCCCOc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL18775 67184 1 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 307 7 0 3 5.0 CCCCOc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
136167006 91616 0 None 6 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 408 5 1 3 5.9 Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407950 91616 0 None 6 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 408 5 1 3 5.9 Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
73349428 92730 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 522 6 0 3 7.4 O=C(c1ccco1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1F 10.1016/j.ejmech.2013.07.050
CHEMBL2435944 92730 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 522 6 0 3 7.4 O=C(c1ccco1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1F 10.1016/j.ejmech.2013.07.050
12113821 197426 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 511 3 1 4 7.6 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\OC(C)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL569634 197426 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 511 3 1 4 7.6 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\OC(C)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
611 2327 75 None 50 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/ml200256d
9903 2327 75 None 50 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/ml200256d
CHEMBL1478 2327 75 None 50 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/ml200256d
9910920 197138 1 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acs.jmedchem.6b01126
CHEMBL567835 197138 1 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acs.jmedchem.6b01126
71626228 118828 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 10 0 7 5.8 CCOC(=O)CN(C)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421898 118828 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 10 0 7 5.8 CCOC(=O)CN(C)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
44605617 198319 1 None 5 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayAgonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/jm901434t
CHEMBL576138 198319 1 None 5 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayAgonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/jm901434t
118103736 164236 0 None 1 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 453 5 0 4 5.1 O=C([C@@H]1CSCN1Cc1cc(C2CC2)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4211208 164236 0 None 1 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 453 5 0 4 5.1 O=C([C@@H]1CSCN1Cc1cc(C2CC2)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232531 199450 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccc(F)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL591455 199450 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccc(F)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232985 200889 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(F)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601449 200889 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(F)cc1 10.1016/j.bmcl.2010.01.003
44605615 198772 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayAgonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 374 4 0 3 5.6 CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1cccc(Cl)c1 10.1021/jm901434t
CHEMBL583110 198772 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayAgonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 374 4 0 3 5.6 CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1cccc(Cl)c1 10.1021/jm901434t
44605615 198772 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 4 0 3 5.6 CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1cccc(Cl)c1 10.1016/j.bmcl.2010.01.003
CHEMBL583110 198772 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 4 0 3 5.6 CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1cccc(Cl)c1 10.1016/j.bmcl.2010.01.003
46232594 201064 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL602690 201064 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2010.01.003
71660856 164206 0 None -1 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 406 3 0 3 5.1 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4210879 164206 0 None -1 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 406 3 0 3 5.1 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 10.1021/acs.jmedchem.8b00308
10479586 106196 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 442 5 3 4 4.3 C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL3138525 106196 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 442 5 3 4 4.3 C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
9848818 97900 53 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.ejmech.2015.09.024
CHEMBL272427 97900 53 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.ejmech.2015.09.024
118586280 158287 0 None 1 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 493 6 0 4 7.7 CN(c1ccc(Cl)c(Cl)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4088938 158287 0 None 1 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 493 6 0 4 7.7 CN(c1ccc(Cl)c(Cl)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
71691935 173248 8 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 461 4 3 4 4.0 C[C@H](CCC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL4524597 173248 8 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 461 4 3 4 4.0 C[C@H](CCC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
118464701 158190 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 548 6 0 4 8.4 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(F)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4087791 158190 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 548 6 0 4 8.4 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(F)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
73357024 92713 0 None 1 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 471 5 1 3 6.4 N#CC(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435926 92713 0 None 1 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 471 5 1 3 6.4 N#CC(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
71626697 112205 0 None -3 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 427 4 0 5 5.7 O=C(c1cnccc1Oc1ccc2sccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290711 112205 0 None -3 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 427 4 0 5 5.7 O=C(c1cnccc1Oc1ccc2sccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
137645502 157658 0 None 1 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 490 7 0 7 5.8 COc1ccc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4081476 157658 0 None 1 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 490 7 0 7 5.8 COc1ccc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
145973129 163031 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 459 5 3 5 5.6 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCc3cc(O)no3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4175888 163031 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 459 5 3 5 5.6 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCc3cc(O)no3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
90644450 112223 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 9 1 9 4.6 CCOC(=O)CNC(=O)Cc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290729 112223 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 9 1 9 4.6 CCOC(=O)CNC(=O)Cc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
73353937 92705 0 None 20 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 588 6 0 5 7.0 O=C(c1ccsc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435914 92705 0 None 20 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 588 6 0 5 7.0 O=C(c1ccsc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
46232736 201308 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1039/C2MD20174G
CHEMBL604131 201308 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1039/C2MD20174G
71626905 118826 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 596 10 1 7 5.4 CCOC(=O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421896 118826 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 596 10 1 7 5.4 CCOC(=O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
71461056 83008 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 387 4 0 4 5.2 Cc1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl 10.1021/jm301071h
CHEMBL2181242 83008 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 387 4 0 4 5.2 Cc1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl 10.1021/jm301071h
130361940 159307 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 447 7 3 3 5.3 CCCCNC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL4099757 159307 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 447 7 3 3 5.3 CCCCNC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
115245 95817 42 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 433 6 3 3 4.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL258818 95817 42 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 433 6 3 3 4.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
71453904 83013 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 3 0 4 5.2 O=C(c1nccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
CHEMBL2181248 83013 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 3 0 4 5.2 O=C(c1nccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
71561368 87628 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2ccc(Cl)cc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336213 87628 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2ccc(Cl)cc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
137656815 159738 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4104842 159738 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
73352467 92715 0 None -8 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 496 5 1 3 5.5 O=S(=O)(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435928 92715 0 None -8 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 496 5 1 3 5.5 O=S(=O)(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
54586161 61167 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 551 8 3 4 7.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)OC/C=C/c3ccccc3)[C@@H]2[C@@H]1O 10.1016/j.bmc.2011.03.004
CHEMBL1765565 61167 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 551 8 3 4 7.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)OC/C=C/c3ccccc3)[C@@H]2[C@@H]1O 10.1016/j.bmc.2011.03.004
45483949 3582 35 None -2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml300277t
7048 3582 35 None -2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml300277t
CHEMBL567640 3582 35 None -2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml300277t
118464805 157798 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 544 6 0 4 8.4 COc1cc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4083189 157798 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 544 6 0 4 8.4 COc1cc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
611 2327 75 None 50 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm900872z
9903 2327 75 None 50 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm900872z
CHEMBL1478 2327 75 None 50 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm900872z
156705115 182119 0 None -3 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 527 7 0 9 4.9 CC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4782069 182119 0 None -3 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 527 7 0 9 4.9 CC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
71541719 87289 1 None -281 3 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at mouse TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at mouse TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
CHEMBL2331646 87289 1 None -281 3 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at mouse TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at mouse TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
130361815 170478 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 447 8 1 5 4.2 C[C@H](CCC(N)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](OC=O)C[C@H]1C[C@H]3OC=O 10.1021/acs.jmedchem.9b00770
CHEMBL4449000 170478 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 447 8 1 5 4.2 C[C@H](CCC(N)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](OC=O)C[C@H]1C[C@H]3OC=O 10.1021/acs.jmedchem.9b00770
162671787 182842 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 876 23 13 15 -2.2 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N(CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1039/d0md00425a
CHEMBL4791399 182842 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 876 23 13 15 -2.2 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N(CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1039/d0md00425a
155669591 182696 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 376 4 0 4 3.7 O=C(c1cncn1Cc1ccc(F)cc1)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4789395 182696 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 376 4 0 4 3.7 O=C(c1cncn1Cc1ccc(F)cc1)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
137646061 157815 0 None 3 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 502 9 0 6 6.7 COc1ccc(OCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4083324 157815 0 None 3 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 502 9 0 6 6.7 COc1ccc(OCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
137634612 156115 0 None -35 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 518 9 0 6 7.4 COc1ccc(SCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4063237 156115 0 None -35 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 518 9 0 6 7.4 COc1ccc(SCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
156018264 177791 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 373 2 2 3 4.9 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@@](C)(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
CHEMBL4643368 177791 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 373 2 2 3 4.9 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@@](C)(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
71626905 118826 0 None -1 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 596 10 1 7 5.4 CCOC(=O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421896 118826 0 None -1 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 596 10 1 7 5.4 CCOC(=O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
71720725 87651 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 428 4 0 5 5.1 Cc1nn(C)c(Oc2cccc(Cl)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336239 87651 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 428 4 0 5 5.1 Cc1nn(C)c(Oc2cccc(Cl)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
136167037 91620 0 None -1 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407954 91620 0 None -1 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
90284086 117677 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 418 5 2 2 6.4 CC[C@H]1C[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
CHEMBL3401354 117677 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 418 5 2 2 6.4 CC[C@H]1C[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
611 2327 75 None 50 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
9903 2327 75 None 50 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
CHEMBL1478 2327 75 None 50 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
73352464 92707 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 410 5 1 2 6.1 FC(F)(F)c1cc(CNCc2cnccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435918 92707 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 410 5 1 2 6.1 FC(F)(F)c1cc(CNCc2cnccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
1452577 109937 1 None 4 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccccc3)C2)n1 10.1021/jm401731q
CHEMBL3234550 109937 1 None 4 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccccc3)C2)n1 10.1021/jm401731q
71626229 118831 0 None 2 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 9 1 6 5.3 CN(CC(=O)O)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421901 118831 0 None 2 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 9 1 6 5.3 CN(CC(=O)O)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
71626493 112198 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1ccc2cccnc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290704 112198 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1ccc2cccnc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
137641119 157009 0 None 28 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 636 12 0 8 6.2 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)/N=C/N(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4073356 157009 0 None 28 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 636 12 0 8 6.2 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)/N=C/N(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
92880 96194 15 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 390 4 1 3 5.6 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL260735 96194 15 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 390 4 1 3 5.6 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
71461058 83021 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 456 6 0 5 5.8 CCCCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181257 83021 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 456 6 0 5 5.8 CCCCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
156705100 182249 0 None -4 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 567 7 0 10 5.5 Cc1oc(=O)oc1COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4783601 182249 0 None -4 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 567 7 0 10 5.5 Cc1oc(=O)oc1COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
90654590 109959 0 None -1 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 502 6 1 8 2.1 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234571 109959 0 None -1 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 502 6 1 8 2.1 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
45273910 113559 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 413 3 0 4 5.3 CN1CCN(C(=O)c2cccnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL3321841 113559 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 413 3 0 4 5.3 CN1CCN(C(=O)c2cccnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
90644455 112227 0 None 1 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 9 1 8 5.9 CCOC(=O)CNC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290733 112227 0 None 1 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 9 1 8 5.9 CCOC(=O)CNC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
71453901 83004 0 None 10 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 5 0 4 5.8 C=CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181238 83004 0 None 10 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 5 0 4 5.8 C=CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
71450251 82991 28 None -8 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 4 0 4 5.1 Cc1ccc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
CHEMBL2181226 82991 28 None -8 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 4 0 4 5.1 Cc1ccc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
118103729 164231 0 None - 1 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 676 14 3 7 5.0 O=C(O)CC[C@H](NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
CHEMBL4211123 164231 0 None - 1 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 676 14 3 7 5.0 O=C(O)CC[C@H](NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
118093535 164446 0 None 5 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 10 1.4 O=C(CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4213844 164446 0 None 5 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 10 1.4 O=C(CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
118093557 164659 0 None 3 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 477 5 1 5 4.4 O=C([C@@H]1CSCN1Cc1cc(Cl)c(CO)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4216682 164659 0 None 3 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 477 5 1 5 4.4 O=C([C@@H]1CSCN1Cc1cc(Cl)c(CO)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
71561504 87635 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@@H]1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336222 87635 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@@H]1c1cccnc1 10.1016/j.bmcl.2012.12.076
155669601 181009 0 None 91 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1ccc(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4759025 181009 0 None 91 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1ccc(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
90654569 109936 1 None 2 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234549 109936 1 None 2 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
71561755 87283 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 438 6 0 6 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cncs1)C(C)C 10.1016/j.bmcl.2012.12.076
CHEMBL2331604 87283 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 438 6 0 6 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cncs1)C(C)C 10.1016/j.bmcl.2012.12.076
71626560 112206 0 None -3 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 428 4 0 6 5.1 O=C(c1cnccc1Oc1ccc2ncsc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290712 112206 0 None -3 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 428 4 0 6 5.1 O=C(c1cnccc1Oc1ccc2ncsc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
156705111 182930 0 None -2 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 455 5 1 6 4.9 O=C(O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4792593 182930 0 None -2 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 455 5 1 6 4.9 O=C(O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
137638975 156875 0 None - 1 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 546 10 1 7 6.6 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4071870 156875 0 None - 1 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 546 10 1 7 6.6 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
92803 167332 31 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 360 4 1 1 6.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CCCC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL429432 167332 31 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 360 4 1 1 6.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CCCC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
73347897 92712 0 None 6 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 435 5 1 3 6.1 N#CC(NCc1cnccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435925 92712 0 None 6 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 435 5 1 3 6.1 N#CC(NCc1cnccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
10133 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2015.01.048
145714624 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2015.01.048
4361 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2015.01.048
608 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2015.01.048
CHEMBL240597 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2015.01.048
DB06777 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2015.01.048
155669601 181009 0 None -91 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1ccc(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4759025 181009 0 None -91 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1ccc(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
76318386 106025 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 391 4 0 5 4.3 COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
CHEMBL3132969 106025 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 391 4 0 5 4.3 COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
44457506 157306 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 374 4 1 1 6.8 C[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL407713 157306 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 374 4 1 1 6.8 C[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
73352467 92715 0 None 8 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 496 5 1 3 5.5 O=S(=O)(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435928 92715 0 None 8 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 496 5 1 3 5.5 O=S(=O)(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
155339364 182716 0 None 1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 583 11 6 8 1.9 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1039/d0md00425a
CHEMBL4789628 182716 0 None 1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 583 11 6 8 1.9 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1039/d0md00425a
118464749 158579 0 None - 1 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 562 7 0 4 8.4 COc1cc(C2(CF)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4091882 158579 0 None - 1 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 562 7 0 4 8.4 COc1cc(C2(CF)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
162646016 179471 0 None - 1 Human 4.2 pEC50 = 4.2 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acs.jmedchem.6b01126
CHEMBL4740844 179471 0 None - 1 Human 4.2 pEC50 = 4.2 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acs.jmedchem.6b01126
118464630 158654 0 None - 1 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 574 6 0 4 8.3 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Br)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4092628 158654 0 None - 1 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 574 6 0 4 8.3 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Br)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
5879 206331 49 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]1CCC2=O 10.1021/jm7015864
CHEMBL87285 206331 49 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]1CCC2=O 10.1021/jm7015864
44627313 197761 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 510 4 2 2 8.4 C=C(C)C[C@@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
CHEMBL571735 197761 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 510 4 2 2 8.4 C=C(C)C[C@@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
73349426 92714 0 None 12 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 478 5 1 3 5.4 O=S(=O)(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435927 92714 0 None 12 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 478 5 1 3 5.4 O=S(=O)(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
90327488 112217 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 503 5 1 6 5.9 Cc1c(C(=O)O)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290723 112217 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 503 5 1 6 5.9 Cc1c(C(=O)O)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
90654591 109960 0 None -1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 6 2 8 1.7 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cn1 10.1021/jm401731q
CHEMBL3234572 109960 0 None -1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 6 2 8 1.7 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cn1 10.1021/jm401731q
90654580 109948 0 None -4 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 367 5 1 5 2.4 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)ncc1F 10.1021/jm401731q
CHEMBL3234561 109948 0 None -4 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 367 5 1 5 2.4 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)ncc1F 10.1021/jm401731q
118093541 163519 0 None -7 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4202603 163519 0 None -7 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
71660979 163543 0 None 1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4202908 163543 0 None 1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
145967535 164793 0 None -15 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 15 6 10 2.3 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4218315 164793 0 None -15 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 15 6 10 2.3 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
46233054 200722 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1cc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)ccc1Cl 10.1016/j.bmcl.2010.01.003
CHEMBL600020 200722 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1cc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)ccc1Cl 10.1016/j.bmcl.2010.01.003
46232737 200880 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 4 0 3 4.8 CCc1onc(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601428 200880 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 4 0 3 4.8 CCc1onc(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232570 201197 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccccc1-c1noc(C)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL603500 201197 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccccc1-c1noc(C)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
71661186 164282 0 None 3 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 532 9 1 5 5.6 NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4211892 164282 0 None 3 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 532 9 1 5 5.6 NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
145971348 164570 0 None -1 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 481 4 0 4 5.2 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1C(F)(F)F)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4215354 164570 0 None -1 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 481 4 0 4 5.2 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1C(F)(F)F)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46233020 199347 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cccc(Cl)c1 10.1016/j.bmcl.2010.01.003
CHEMBL590739 199347 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cccc(Cl)c1 10.1016/j.bmcl.2010.01.003
46232626 199504 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.9 Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL591927 199504 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.9 Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232627 200923 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 378 3 0 3 5.4 Cc1onc(-c2c(F)cccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601670 200923 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 378 3 0 3 5.4 Cc1onc(-c2c(F)cccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232984 201423 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cccc(F)c1 10.1016/j.bmcl.2010.01.003
CHEMBL604752 201423 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cccc(F)c1 10.1016/j.bmcl.2010.01.003
71661224 164140 0 None 1 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 415 4 0 3 4.6 O=C([C@@H]1CCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4210112 164140 0 None 1 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 415 4 0 3 4.6 O=C([C@@H]1CCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118103718 164521 0 None -1 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 9 1.4 O=C(CCc1cc(Cl)c(CN2C[C@@H](F)C[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4214838 164521 0 None -1 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 9 1.4 O=C(CCc1cc(Cl)c(CN2C[C@@H](F)C[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
44605617 198319 1 None -5 2 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/jm901434t
CHEMBL576138 198319 1 None -5 2 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/jm901434t
46232411 201377 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 368 5 0 3 5.5 CCCc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL604524 201377 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 368 5 0 3 5.5 CCCc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
71626555 112197 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1ccc2ncccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290703 112197 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1ccc2ncccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
58043236 91606 0 None -2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407933 91606 0 None -2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
71561881 87641 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 447 4 0 6 4.9 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1nccn1C 10.1016/j.bmcl.2012.12.076
CHEMBL2336228 87641 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 447 4 0 6 4.9 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1nccn1C 10.1016/j.bmcl.2012.12.076
71561367 87627 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 412 4 0 5 4.6 Cc1nn(C)c(Oc2cccc(F)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336212 87627 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 412 4 0 5 4.6 Cc1nn(C)c(Oc2cccc(F)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
46196449 77210 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C[C@H](O)[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml200256d
CHEMBL2062554 77210 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C[C@H](O)[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml200256d
CHEMBL2079386 77210 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C[C@H](O)[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml200256d
71626489 112194 0 None -3 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 421 4 0 4 5.7 O=C(c1cnccc1Oc1cccc2ccccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290700 112194 0 None -3 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 421 4 0 4 5.7 O=C(c1cnccc1Oc1cccc2ccccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
77846087 112212 0 None -8 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 537 4 0 5 7.0 Cc1c(Br)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290718 112212 0 None -8 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 537 4 0 5 7.0 Cc1c(Br)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71453901 83004 0 None -10 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 5 0 4 5.8 C=CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181238 83004 0 None -10 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 5 0 4 5.8 C=CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
156019635 177989 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 387 3 2 3 5.3 CC[C@@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4646200 177989 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 387 3 2 3 5.3 CC[C@@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
89501425 161548 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 539 9 0 5 7.8 CC(C)(c1ccc(Cl)c(Cl)c1)c1cnc(SCCOCc2ccc(C#N)cc2)n1-c1ccc(F)cc1 10.1016/j.bmcl.2018.04.011
CHEMBL4128688 161548 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 539 9 0 5 7.8 CC(C)(c1ccc(Cl)c(Cl)c1)c1cnc(SCCOCc2ccc(C#N)cc2)n1-c1ccc(F)cc1 10.1016/j.bmcl.2018.04.011
10133 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
145714624 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
4361 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
608 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
CHEMBL240597 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
DB06777 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
10133 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
145714624 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
4361 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
608 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
CHEMBL240597 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
DB06777 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
10133 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
145714624 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
4361 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
608 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
CHEMBL240597 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
DB06777 910 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
77845284 112220 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 517 7 1 6 5.9 O=C(O)CCc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290726 112220 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 517 7 1 6 5.9 O=C(O)CCc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
118464815 159516 0 None 6 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 528 6 0 4 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4102107 159516 0 None 6 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 528 6 0 4 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
118586298 158026 0 None 2 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 449 8 0 6 6.1 COc1ccc(N(C)c2cnc(SCc3ccccc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4085664 158026 0 None 2 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 449 8 0 6 6.1 COc1ccc(N(C)c2cnc(SCc3ccccc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
164620833 185558 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 565 6 2 4 7.0 CCNS(=O)(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4863256 185558 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 565 6 2 4 7.0 CCNS(=O)(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
118464664 157190 0 None -2 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 478 6 0 6 5.9 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4075703 157190 0 None -2 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 478 6 0 6 5.9 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
118464811 156790 0 None 5 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)ccc(OCCOCCOCCN(C)C)c4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4070895 156790 0 None 5 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)ccc(OCCOCCOCCN(C)C)c4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
611 2327 75 None 50 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1016/j.bmc.2015.01.048
9903 2327 75 None 50 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1016/j.bmc.2015.01.048
CHEMBL1478 2327 75 None 50 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1016/j.bmc.2015.01.048
2733768 161300 28 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1016/j.ejmech.2015.09.024
CHEMBL412272 161300 28 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1016/j.ejmech.2015.09.024
71461055 83003 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 441 4 0 4 6.1 CC(C)N1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181237 83003 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 441 4 0 4 6.1 CC(C)N1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
118455251 156359 0 None - 1 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4065966 156359 0 None - 1 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
156014434 177231 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 373 2 2 3 4.9 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@](C)(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
CHEMBL4635684 177231 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 373 2 2 3 4.9 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@](C)(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
44479724 197093 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 472 2 2 3 6.3 CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@H]3[C@H]([C@]4(C)CO4)CC[C@]3(C(=O)O)CC[C@]21C 10.1021/jm900872z
CHEMBL567578 197093 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 472 2 2 3 6.3 CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@H]3[C@H]([C@]4(C)CO4)CC[C@]3(C(=O)O)CC[C@]21C 10.1021/jm900872z
156705091 182207 0 None 20 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 515 7 0 8 5.7 CSCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4783037 182207 0 None 20 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 515 7 0 8 5.7 CSCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
126673445 157548 0 None 47 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 8 0 6 6.7 COc1ccc(N(C)c2c(C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4080290 157548 0 None 47 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 8 0 6 6.7 COc1ccc(N(C)c2c(C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71459276 83002 0 None 10 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 441 5 0 4 6.1 CCCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181236 83002 0 None 10 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 441 5 0 4 6.1 CCCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
118577298 160986 0 None 18 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4086463 160986 0 None 18 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4096633 160986 0 None 18 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116110 160986 0 None 18 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
77846087 112212 0 None 8 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 537 4 0 5 7.0 Cc1c(Br)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290718 112212 0 None 8 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 537 4 0 5 7.0 Cc1c(Br)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
126673504 157615 0 None 10 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 511 10 0 6 6.9 C=CCN(c1ccc(OC)c(OC)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4081050 157615 0 None 10 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 511 10 0 6 6.9 C=CCN(c1ccc(OC)c(OC)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
71561366 87626 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336211 87626 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
71561884 87648 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 430 6 0 5 5.0 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CC1 10.1016/j.bmcl.2012.12.076
CHEMBL2336236 87648 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 430 6 0 5 5.0 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CC1 10.1016/j.bmcl.2012.12.076
71459274 82987 0 None 3 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1cccc(Cl)c1)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181222 82987 0 None 3 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1cccc(Cl)c1)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
46232530 200885 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2cccc(F)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601440 200885 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2cccc(F)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
118093541 163519 0 None 7 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4202603 163519 0 None 7 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118103740 163554 0 None 25 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cn1 10.1021/acs.jmedchem.8b00308
CHEMBL4202994 163554 0 None 25 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cn1 10.1021/acs.jmedchem.8b00308
71561882 87646 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 446 7 0 5 5.7 CCC(C)N(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL2336234 87646 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 446 7 0 5 5.7 CCC(C)N(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
121322331 162887 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 497 6 3 5 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NS(C)(=O)=O)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4173597 162887 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 497 6 3 5 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NS(C)(=O)=O)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
15818 115436 25 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 292 0 2 2 3.8 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
CHEMBL335062 115436 25 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 292 0 2 2 3.8 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
118576999 159705 0 None -17 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 566 9 0 7 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CCN(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4104359 159705 0 None -17 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 566 9 0 7 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CCN(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71453906 83018 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 442 4 0 5 5.5 CC(C)N1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181254 83018 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 442 4 0 5 5.5 CC(C)N1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
71626832 118825 0 None -2 2 Mouse 4.2 pEC50 = 4.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 511 7 1 5 5.8 O=C(O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421894 118825 0 None -2 2 Mouse 4.2 pEC50 = 4.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 511 7 1 5 5.8 O=C(O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
90644444 112229 0 None -4 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 587 8 0 8 6.1 CCOC(=O)CCc1oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290735 112229 0 None -4 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 587 8 0 8 6.1 CCOC(=O)CCc1oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
90654578 109946 0 None -3 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1cccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234559 109946 0 None -3 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1cccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
118464680 158660 0 None 46 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1ccc([C@@H]2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4092785 158660 0 None 46 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1ccc([C@@H]2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
90284520 117679 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 434 5 3 3 5.4 CC[C@H]1[C@H](O)[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
CHEMBL3401356 117679 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 434 5 3 3 5.4 CC[C@H]1[C@H](O)[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
44457480 157963 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 495 8 2 3 6.1 CC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL408477 157963 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 495 8 2 3 6.1 CC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@H]12 10.1021/jm7015864
14650410 190199 16 None -6 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 265 4 1 3 3.3 OCc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5174405 190199 16 None -6 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 265 4 1 3 3.3 OCc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
118464628 157973 0 None - 1 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4cc(F)ccc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4084863 157973 0 None - 1 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4cc(F)ccc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
73346391 92724 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 548 6 0 2 8.3 O=C(c1ccc(Cl)cc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435938 92724 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 548 6 0 2 8.3 O=C(c1ccc(Cl)cc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
71540073 87291 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331648 87291 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71540073 87291 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1016/j.bmcl.2012.12.076
CHEMBL2331648 87291 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1016/j.bmcl.2012.12.076
136166936 91604 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407931 91604 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
137645502 157658 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 490 7 0 7 5.8 COc1ccc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4081476 157658 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 490 7 0 7 5.8 COc1ccc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
118728411 117676 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 404 5 2 2 6.1 CC[C@H]1C[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCC(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
CHEMBL3401353 117676 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 404 5 2 2 6.1 CC[C@H]1C[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCC(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
118586280 158287 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 493 6 0 4 7.7 CN(c1ccc(Cl)c(Cl)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4088938 158287 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 493 6 0 4 7.7 CN(c1ccc(Cl)c(Cl)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
90654570 109938 0 None -2 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 342 5 1 4 2.5 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(F)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234551 109938 0 None -2 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 342 5 1 4 2.5 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(F)cc3)C2)n1 10.1021/jm401731q
447715 196927 68 None 9 7 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/jm070633p
CHEMBL566315 196927 68 None 9 7 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/jm070633p
11258221 158876 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 404 3 3 3 4.3 C[C@H]([C@H]1C[C@H]1C(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL409510 158876 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 404 3 3 3 4.3 C[C@H]([C@H]1C[C@H]1C(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
126016 97451 8 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 390 4 2 2 5.8 CC1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL270105 97451 8 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 390 4 2 2 5.8 CC1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
90654583 109951 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1cc(N2CCN(C)CC2)nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234564 109951 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1cc(N2CCN(C)CC2)nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
71459276 83002 0 None -10 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 441 5 0 4 6.1 CCCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181236 83002 0 None -10 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 441 5 0 4 6.1 CCCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
155339369 182782 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 406 5 2 3 5.1 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]21 10.1039/d0md00425a
CHEMBL4790399 182782 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 406 5 2 3 5.1 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]21 10.1039/d0md00425a
137653533 158763 0 None 48 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 702 16 5 9 5.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NC(CCCNC(=N)N)C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4094009 158763 0 None 48 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 702 16 5 9 5.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NC(CCCNC(=N)N)C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
126673452 161153 0 None -257 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 774 19 2 12 5.2 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4087611 161153 0 None -257 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 774 19 2 12 5.2 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4117342 161153 0 None -257 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 774 19 2 12 5.2 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
164613452 184941 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 564 6 1 4 7.9 CCCS(=O)(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4853647 184941 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 564 6 1 4 7.9 CCCS(=O)(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
118464803 155784 0 None -15 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 525 7 0 6 6.6 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cncc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4059508 155784 0 None -15 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 525 7 0 6 6.6 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cncc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
44372731 54396 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 362 3 2 2 5.1 CC(CC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL160902 54396 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 362 3 2 2 5.1 CC(CC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
44626704 197731 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 525 4 1 4 8.0 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\OC(=O)CC)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL571482 197731 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 525 4 1 4 8.0 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\OC(=O)CC)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
118577093 158037 0 None -8 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 497 9 0 7 6.2 COc1ccc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4085777 158037 0 None -8 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 497 9 0 7 6.2 COc1ccc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)cc1 10.1021/acs.jmedchem.6b01873
118464729 156949 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 532 6 0 5 7.4 COc1cc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4072719 156949 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 532 6 0 5 7.4 COc1cc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
90644445 112221 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 8 1 9 4.9 CCOC(=O)CNC(=O)c1oc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290727 112221 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 8 1 9 4.9 CCOC(=O)CNC(=O)c1oc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2c1C 10.1016/j.ejmech.2014.05.031
71541721 87287 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 367 6 2 5 1.8 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C)cc1)CC2 10.1021/ml300277t
CHEMBL2331644 87287 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 367 6 2 5 1.8 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C)cc1)CC2 10.1021/ml300277t
156011870 177320 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 427 6 2 3 6.3 C=CCCC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4637054 177320 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 427 6 2 3 6.3 C=CCCC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
44457500 155774 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 402 6 1 1 7.6 CCC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL405879 155774 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 402 6 1 1 7.6 CCC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
71626228 118828 0 None -1 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 10 0 7 5.8 CCOC(=O)CN(C)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421898 118828 0 None -1 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 10 0 7 5.8 CCOC(=O)CN(C)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
44626600 197735 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 551 6 1 4 8.6 C=CCCC(=O)O/N=C1\CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
CHEMBL571515 197735 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 551 6 1 4 8.6 C=CCCC(=O)O/N=C1\CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
145975890 163803 0 None -19 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 16 7 10 2.3 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4206078 163803 0 None -19 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 16 7 10 2.3 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
118103697 163957 0 None -7 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4207801 163957 0 None -7 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118093476 164103 0 None -39 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 780 14 6 13 2.1 Cn1c(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4209669 164103 0 None -39 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 780 14 6 13 2.1 Cn1c(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
44605617 198319 1 None 5 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/jm901434t
CHEMBL576138 198319 1 None 5 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/jm901434t
44605617 198319 1 None 5 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1016/j.bmcl.2010.01.003
CHEMBL576138 198319 1 None 5 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1016/j.bmcl.2010.01.003
46232568 201098 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2010.01.003
CHEMBL602892 201098 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2010.01.003
2733768 161300 28 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1021/jm7015864
CHEMBL412272 161300 28 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1021/jm7015864
118104385 163583 0 None -5 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 648 13 6 10 0.7 O=C(CCc1ccc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)c1)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4203321 163583 0 None -5 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 648 13 6 10 0.7 O=C(CCc1ccc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)c1)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
89651284 164646 0 None 1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 432 6 0 3 5.6 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CCC1 10.1021/acs.jmedchem.8b00308
CHEMBL4216520 164646 0 None 1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 432 6 0 3 5.6 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CCC1 10.1021/acs.jmedchem.8b00308
118093506 164722 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4217450 164722 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232697 199595 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 416 5 0 3 6.8 CC(C)c1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C(C)C 10.1016/j.bmcl.2010.01.003
CHEMBL592645 199595 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 416 5 0 3 6.8 CC(C)c1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C(C)C 10.1016/j.bmcl.2010.01.003
118103736 164236 0 None -1 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 453 5 0 4 5.1 O=C([C@@H]1CSCN1Cc1cc(C2CC2)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4211208 164236 0 None -1 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 453 5 0 4 5.1 O=C([C@@H]1CSCN1Cc1cc(C2CC2)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093511 164025 0 None -3 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 388 3 0 2 4.9 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4208655 164025 0 None -3 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 388 3 0 2 4.9 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.8b00308
46232528 201016 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 384 4 0 5 4.4 COC(=O)c1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL602273 201016 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 384 4 0 5 4.4 COC(=O)c1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
46232413 201419 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 382 3 0 3 5.9 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(C)(C)C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL604734 201419 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 382 3 0 3 5.9 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(C)(C)C)cc1 10.1016/j.bmcl.2010.01.003
90654574 109942 0 None 4 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 376 5 1 4 3.2 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)ncc1F 10.1021/jm401731q
CHEMBL3234555 109942 0 None 4 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 376 5 1 4 3.2 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)ncc1F 10.1021/jm401731q
90654564 109963 0 None -1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234575 109963 0 None -1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
76318387 106028 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 417 5 0 5 4.9 COc1cccc(-c2noc(C3CC3)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
CHEMBL3132971 106028 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 417 5 0 5 4.9 COc1cccc(-c2noc(C3CC3)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
90644455 112227 0 None -1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 9 1 8 5.9 CCOC(=O)CNC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290733 112227 0 None -1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 9 1 8 5.9 CCOC(=O)CNC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
90644456 112225 0 None 1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 557 7 0 7 6.8 CCOC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290731 112225 0 None 1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 557 7 0 7 6.8 CCOC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
136167004 91603 7 None 1 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407930 91603 7 None 1 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
164618838 185786 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 530 4 1 4 8.4 CCOC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4866697 185786 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 530 4 1 4 8.4 CCOC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
71626834 118830 0 None -2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 10 2 6 5.3 O=C(O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421900 118830 0 None -2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 10 2 6 5.3 O=C(O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
118735265 118829 0 None 1 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 568 9 2 6 4.9 O=C(O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421899 118829 0 None 1 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 568 9 2 6 4.9 O=C(O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
156705085 182987 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 543 10 0 9 5.0 COCCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4793377 182987 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 543 10 0 9 5.0 COCCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
118464738 156714 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 564 6 0 4 8.9 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(Cl)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4070183 156714 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 564 6 0 4 8.9 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(Cl)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
90654576 109944 0 None 1 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccncn2)C1 10.1021/jm401731q
CHEMBL3234557 109944 0 None 1 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccncn2)C1 10.1021/jm401731q
90644446 112216 0 None -3 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 559 7 0 8 5.4 COC(=O)CCc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290722 112216 0 None -3 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 559 7 0 8 5.4 COC(=O)CCc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
126673489 156671 0 None 13 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 571 11 0 8 6.5 COC(=O)CCc1nc(SCc2c(F)cccc2F)n(-c2ccc(F)cc2)c1N(C)c1ccc(OC)c(OC)c1 10.1021/acs.jmedchem.6b01873
CHEMBL4069569 156671 0 None 13 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 571 11 0 8 6.5 COC(=O)CCc1nc(SCc2c(F)cccc2F)n(-c2ccc(F)cc2)c1N(C)c1ccc(OC)c(OC)c1 10.1021/acs.jmedchem.6b01873
45483949 3582 35 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml200256d
7048 3582 35 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml200256d
CHEMBL567640 3582 35 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml200256d
44605418 196758 22 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1021/jm901390p
CHEMBL565278 196758 22 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1021/jm901390p
45483949 3582 35 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmc.2020.115972
7048 3582 35 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmc.2020.115972
CHEMBL567640 3582 35 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmc.2020.115972
73349426 92714 0 None -12 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 478 5 1 3 5.4 O=S(=O)(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435927 92714 0 None -12 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 478 5 1 3 5.4 O=S(=O)(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
137661039 159489 0 None -21 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 653 13 2 9 5.5 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4101738 159489 0 None -21 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 653 13 2 9 5.5 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
71540078 87296 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 422 6 1 5 2.6 CCc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331653 87296 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 422 6 1 5 2.6 CCc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
164623929 186241 0 None 31 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 528 5 1 3 8.5 CCCC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4873587 186241 0 None 31 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 528 5 1 3 8.5 CCCC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
156705120 181873 0 None 41 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 503 6 0 7 5.6 O=C(OCCl)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4778884 181873 0 None 41 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 503 6 0 7 5.6 O=C(OCCl)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
155669600 179776 0 None -87 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4744582 179776 0 None -87 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
71541720 87286 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 353 6 2 5 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccccc1)CC2 10.1021/ml300277t
CHEMBL2331643 87286 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 353 6 2 5 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccccc1)CC2 10.1021/ml300277t
447715 196927 68 None 9 7 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL566315 196927 68 None 9 7 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
130361991 169696 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 430 4 2 5 4.9 Cc1noc(CC[C@@H](C)[C@H]2CC[C@H]3[C@H]4[C@H](CC[C@@]32C)[C@@]2(C)CC[C@@H](O)C[C@H]2C[C@H]4O)n1 10.1021/acs.jmedchem.9b00770
CHEMBL4437850 169696 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 430 4 2 5 4.9 Cc1noc(CC[C@@H](C)[C@H]2CC[C@H]3[C@H]4[C@H](CC[C@@]32C)[C@@]2(C)CC[C@@H](O)C[C@H]2C[C@H]4O)n1 10.1021/acs.jmedchem.9b00770
71561619 87640 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 430 4 0 5 5.2 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336227 87640 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 430 4 0 5 5.2 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
439763 158126 22 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acs.jmedchem.9b00770
CHEMBL408701 158126 22 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acs.jmedchem.9b00770
90644447 112231 0 None -2 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 10 1 8 5.8 CCOC(=O)CNC(=O)CCc1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290737 112231 0 None -2 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 10 1 8 5.8 CCOC(=O)CNC(=O)CCc1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
219833 97410 40 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 320 1 2 2 4.4 C[C@H](O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1021/jm7015864
CHEMBL269897 97410 40 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 320 1 2 2 4.4 C[C@H](O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1021/jm7015864
73353940 92719 0 None -27 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 582 6 0 4 7.0 O=C(c1ccccc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435932 92719 0 None -27 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 582 6 0 4 7.0 O=C(c1ccccc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
126673504 157615 0 None -10 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 511 10 0 6 6.9 C=CCN(c1ccc(OC)c(OC)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4081050 157615 0 None -10 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 511 10 0 6 6.9 C=CCN(c1ccc(OC)c(OC)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
164612114 184630 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 512 3 2 3 7.7 CC(C)[C@@H]1CC[C@]2(N)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4849469 184630 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 512 3 2 3 7.7 CC(C)[C@@H]1CC[C@]2(N)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
5284055 97574 4 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 394 4 4 4 3.4 C[C@H](CCCO)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL270703 97574 4 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 394 4 4 4 3.4 C[C@H](CCCO)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
70686470 77209 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C[C@@H](O)[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml200256d
CHEMBL2062553 77209 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C[C@@H](O)[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml200256d
CHEMBL2079385 77209 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C[C@@H](O)[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml200256d
90654571 109939 0 None -2 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 402 5 1 4 3.1 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Br)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234552 109939 0 None -2 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 402 5 1 4 3.1 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Br)cc3)C2)n1 10.1021/jm401731q
136166933 91615 0 None 3 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 394 5 1 3 5.6 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407949 91615 0 None 3 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 394 5 1 3 5.6 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
3223370 109934 2 None 1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)C1CCCN(c2ncccn2)C1 10.1021/jm401731q
CHEMBL3234546 109934 2 None 1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)C1CCCN(c2ncccn2)C1 10.1021/jm401731q
118577011 156986 0 None -20 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 489 7 0 5 7.0 COc1cc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)ccc1Cl 10.1021/acs.jmedchem.6b01873
CHEMBL4073081 156986 0 None -20 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 489 7 0 5 7.0 COc1cc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)ccc1Cl 10.1021/acs.jmedchem.6b01873
118455249 156697 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 530 6 0 4 8.2 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4069934 156697 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 530 6 0 4 8.2 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
2733768 161300 28 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1016/j.ejmech.2015.09.024
CHEMBL412272 161300 28 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1016/j.ejmech.2015.09.024
73346390 92717 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 533 7 0 4 7.8 N#CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccco1)Cc1cnccc1-c1ccccc1F 10.1016/j.ejmech.2013.07.050
CHEMBL2435930 92717 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 533 7 0 4 7.8 N#CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccco1)Cc1cnccc1-c1ccccc1F 10.1016/j.ejmech.2013.07.050
71541722 87288 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 381 7 2 5 2.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC)cc1)CC2 10.1021/ml300277t
CHEMBL2331645 87288 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 381 7 2 5 2.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC)cc1)CC2 10.1021/ml300277t
155669600 179776 0 None 87 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4744582 179776 0 None 87 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
118576918 161131 0 None 24 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 654 13 0 8 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4078612 161131 0 None 24 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 654 13 0 8 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4117224 161131 0 None 24 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 654 13 0 8 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
45483949 3582 35 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/acs.jmedchem.6b01126
7048 3582 35 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/acs.jmedchem.6b01126
CHEMBL567640 3582 35 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/acs.jmedchem.6b01126
118586279 155852 0 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 535 8 0 6 7.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(C(F)(F)F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4060122 155852 0 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 535 8 0 6 7.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(C(F)(F)F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
118586276 156172 0 None 10 2 Mouse 7.0 pEC50 = 7.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1cccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)c1 10.1021/acs.jmedchem.6b01873
CHEMBL4063932 156172 0 None 10 2 Mouse 7.0 pEC50 = 7.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1cccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)c1 10.1021/acs.jmedchem.6b01873
73355479 92721 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 452 5 0 2 6.3 CC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435934 92721 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 452 5 0 2 6.3 CC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
73353941 92720 0 None -28 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 572 6 0 5 6.6 O=C(c1ccco1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435933 92720 0 None -28 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 572 6 0 5 6.6 O=C(c1ccco1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
90283905 117680 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 402 4 1 3 5.1 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@@H]3C(=O)C[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)O 10.1016/j.bmc.2015.01.048
CHEMBL3401357 117680 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 402 4 1 3 5.1 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@@H]3C(=O)C[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)O 10.1016/j.bmc.2015.01.048
71561502 87634 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 376 4 0 5 4.3 Cc1nn(C)c(Oc2ccccc2)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336220 87634 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 376 4 0 5 4.3 Cc1nn(C)c(Oc2ccccc2)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
71561883 87647 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 404 5 0 5 4.5 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(C)Cc1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336235 87647 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 404 5 0 5 4.5 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(C)Cc1cccnc1 10.1016/j.bmcl.2012.12.076
118464747 158334 0 None -4 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 743 19 2 10 6.0 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)NCCOCCOCCOCCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4089352 158334 0 None -4 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 743 19 2 10 6.0 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)NCCOCCOCCOCCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
90654575 109943 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 343 5 1 3 3.3 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccccn2)C1 10.1021/jm401731q
CHEMBL3234556 109943 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 343 5 1 3 3.3 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccccn2)C1 10.1021/jm401731q
90654579 109947 0 None 5 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)c1 10.1021/jm401731q
CHEMBL3234560 109947 0 None 5 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)c1 10.1021/jm401731q
156018124 177890 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 449 4 2 3 6.1 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@](O)(Cc4ccccc4)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
CHEMBL4644760 177890 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 449 4 2 3 6.1 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@](O)(Cc4ccccc4)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
137630926 161135 0 None 3 2 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 681 15 1 8 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)NCCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4086239 161135 0 None 3 2 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 681 15 1 8 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)NCCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4117239 161135 0 None 3 2 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 681 15 1 8 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)NCCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
118577093 158037 0 None 8 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 497 9 0 7 6.2 COc1ccc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4085777 158037 0 None 8 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 497 9 0 7 6.2 COc1ccc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)cc1 10.1021/acs.jmedchem.6b01873
118455177 156273 0 None - 1 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1ccc([C@H]2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4065113 156273 0 None - 1 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1ccc([C@H]2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
89501618 161556 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 563 11 0 8 5.2 COc1ccc(C(C)(C)c2cnc(S(=O)(=O)CCOCc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL4128816 161556 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 563 11 0 8 5.2 COc1ccc(C(C)(C)c2cnc(S(=O)(=O)CCOCc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
118464718 158250 0 None 36 2 Mouse 7.0 pEC50 = 7.0 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 568 8 1 6 6.9 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)O)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4088541 158250 0 None 36 2 Mouse 7.0 pEC50 = 7.0 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 568 8 1 6 6.9 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)O)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
44427762 93228 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 434 5 3 3 5.4 CC[C@@H]1C2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1021/jm070633p
CHEMBL244785 93228 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 434 5 3 3 5.4 CC[C@@H]1C2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1021/jm070633p
45483944 197013 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](O)C(=O)O)[C@@H]2[C@@H]1O 10.1021/jm901390p
CHEMBL566985 197013 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](O)C(=O)O)[C@@H]2[C@@H]1O 10.1021/jm901390p
90654573 109941 0 None 1 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 362 5 1 4 2.8 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncc(F)cn2)C1 10.1021/jm401731q
CHEMBL3234554 109941 0 None 1 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 362 5 1 4 2.8 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncc(F)cn2)C1 10.1021/jm401731q
71561616 87637 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1ccccn1 10.1016/j.bmcl.2012.12.076
CHEMBL2336224 87637 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1ccccn1 10.1016/j.bmcl.2012.12.076
118735265 118829 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 568 9 2 6 4.9 O=C(O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421899 118829 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 568 9 2 6 4.9 O=C(O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
130361906 157977 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 473 6 0 3 6.3 CO[C@@H]1CC[C@@]2(C)[C@@H](C1)C[C@@H](OC)[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@H]2[C@H](C)CCC(=O)N1CCCC1 10.1021/acs.jmedchem.9b00770
CHEMBL4084918 157977 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 473 6 0 3 6.3 CO[C@@H]1CC[C@@]2(C)[C@@H](C1)C[C@@H](OC)[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@H]2[C@H](C)CCC(=O)N1CCCC1 10.1021/acs.jmedchem.9b00770
137634963 155881 0 None 21 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 529 10 0 6 6.3 COc1ccc(N(C=O)Cc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4060463 155881 0 None 21 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 529 10 0 6 6.3 COc1ccc(N(C=O)Cc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
118586276 156172 0 None -10 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1cccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)c1 10.1021/acs.jmedchem.6b01873
CHEMBL4063932 156172 0 None -10 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1cccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)c1 10.1021/acs.jmedchem.6b01873
52941357 17605 0 None 7 2 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 390 7 1 5 5.3 COc1ccc(CNCc2cc3ccc(OC)cc3nc2-c2ccsc2)cc1 10.1016/j.bmcl.2010.08.014
CHEMBL1258196 17605 0 None 7 2 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 390 7 1 5 5.3 COc1ccc(CNCc2cc3ccc(OC)cc3nc2-c2ccsc2)cc1 10.1016/j.bmcl.2010.08.014
52945302 17570 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 360 6 1 4 5.3 COc1ccc2cc(CNCc3ccccc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258081 17570 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 360 6 1 4 5.3 COc1ccc2cc(CNCc3ccccc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52949938 17670 0 None -4 2 Mouse 4.9 pIC50 = 4.9 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3cccc(Br)c3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258424 17670 0 None -4 2 Mouse 4.9 pIC50 = 4.9 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3cccc(Br)c3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
17755104 17569 0 None 1 2 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 434 5 3 3 5.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1016/j.bmcl.2010.08.014
CHEMBL1258080 17569 0 None 1 2 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 434 5 3 3 5.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1016/j.bmcl.2010.08.014
52946277 17434 0 None -19 2 Mouse 5.8 pIC50 = 5.8 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257612 17434 0 None -19 2 Mouse 5.8 pIC50 = 5.8 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2c1 10.1016/j.bmcl.2010.08.014
17755104 17569 0 None -1 2 Mouse 6.6 pIC50 = 6.6 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 434 5 3 3 5.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1016/j.bmcl.2010.08.014
CHEMBL1258080 17569 0 None -1 2 Mouse 6.6 pIC50 = 6.6 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 434 5 3 3 5.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1016/j.bmcl.2010.08.014
52948571 17287 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 437 7 1 5 5.0 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ncco3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257142 17287 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 437 7 1 5 5.0 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ncco3)nc2c1 10.1016/j.bmcl.2010.08.014
136002656 17393 0 None 18 2 Mouse 6.6 pIC50 = 6.6 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257491 17393 0 None 18 2 Mouse 6.6 pIC50 = 6.6 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52949938 17670 0 None 4 2 Human 5.6 pIC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3cccc(Br)c3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258424 17670 0 None 4 2 Human 5.6 pIC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3cccc(Br)c3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52946791 17472 0 None 1 2 Mouse 6.5 pIC50 = 6.5 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 468 7 2 5 5.8 COc1cc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2cc1O 10.1016/j.bmcl.2010.08.014
CHEMBL1257732 17472 0 None 1 2 Mouse 6.5 pIC50 = 6.5 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 468 7 2 5 5.8 COc1cc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2cc1O 10.1016/j.bmcl.2010.08.014
24969872 17669 0 None -10 2 Mouse 5.5 pIC50 = 5.5 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258423 17669 0 None -10 2 Mouse 5.5 pIC50 = 5.5 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
26404327 17635 0 None -38 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 7 1 4 6.0 COc1ccc2cc(CNCCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258311 17635 0 None -38 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 7 1 4 6.0 COc1ccc2cc(CNCCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
24969952 17780 0 None -85 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccncc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258758 17780 0 None -85 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccncc3)nc2c1 10.1016/j.bmcl.2010.08.014
52941356 17604 0 None -4 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 374 6 1 4 5.6 COc1ccc2cc(CNCc3ccc(C)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258195 17604 0 None -4 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 374 6 1 4 5.6 COc1ccc2cc(CNCc3ccc(C)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52945144 17742 0 None -7 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccco3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258645 17742 0 None -7 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccco3)nc2c1 10.1016/j.bmcl.2010.08.014
52946791 17472 0 None -1 2 Human 6.4 pIC50 = 6.4 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 468 7 2 5 5.8 COc1cc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2cc1O 10.1016/j.bmcl.2010.08.014
CHEMBL1257732 17472 0 None -1 2 Human 6.4 pIC50 = 6.4 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 468 7 2 5 5.8 COc1cc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2cc1O 10.1016/j.bmcl.2010.08.014
42429922 17634 3 None -7 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 394 6 1 4 5.9 COc1ccc2cc(CNCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258310 17634 3 None -7 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 394 6 1 4 5.9 COc1ccc2cc(CNCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
24969952 17780 0 None 85 2 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccncc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258758 17780 0 None 85 2 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccncc3)nc2c1 10.1016/j.bmcl.2010.08.014
52946134 17321 0 None 2 2 Human 5.4 pIC50 = 5.4 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 466 8 1 4 6.5 CCOc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257260 17321 0 None 2 2 Human 5.4 pIC50 = 5.4 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 466 8 1 4 6.5 CCOc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52948780 17705 0 None -7 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccs3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258530 17705 0 None -7 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccs3)nc2c1 10.1016/j.bmcl.2010.08.014
52950002 17743 0 None 16 2 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 446 7 1 3 6.0 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccccc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258646 17743 0 None 16 2 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 446 7 1 3 6.0 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccccc3)nc2c1 10.1016/j.bmcl.2010.08.014
52945144 17742 0 None 7 2 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccco3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258645 17742 0 None 7 2 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccco3)nc2c1 10.1016/j.bmcl.2010.08.014
52947341 17288 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 6 1 3 6.4 Cc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257143 17288 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 6 1 3 6.4 Cc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52948858 17815 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 453 7 1 5 5.5 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3nccs3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258878 17815 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 453 7 1 5 5.5 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3nccs3)nc2c1 10.1016/j.bmcl.2010.08.014
24969527 17781 0 None -77 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccnc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258759 17781 0 None -77 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccnc3)nc2c1 10.1016/j.bmcl.2010.08.014
136002656 17393 0 None -18 2 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257491 17393 0 None -18 2 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
221493 921 87 None -2 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
3096 921 87 None -2 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
609 921 87 None -2 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
CHEMBL205596 921 87 None -2 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
DB02659 921 87 None -2 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
52941381 17392 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 422 6 1 3 6.1 Brc1ccc(CCNCc2cc3ccccc3nc2-c2ccsc2)cc1 10.1016/j.bmcl.2010.08.014
CHEMBL1257490 17392 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 422 6 1 3 6.1 Brc1ccc(CCNCc2cc3ccccc3nc2-c2ccsc2)cc1 10.1016/j.bmcl.2010.08.014
42429922 17634 3 None 7 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 394 6 1 4 5.9 COc1ccc2cc(CNCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258310 17634 3 None 7 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 394 6 1 4 5.9 COc1ccc2cc(CNCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52948780 17705 0 None 7 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccs3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258530 17705 0 None 7 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccs3)nc2c1 10.1016/j.bmcl.2010.08.014
221493 921 87 None 2 2 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
3096 921 87 None 2 2 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
609 921 87 None 2 2 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
CHEMBL205596 921 87 None 2 2 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
DB02659 921 87 None 2 2 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
52946355 17706 1 None -8 2 Mouse 5.2 pIC50 = 5.2 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccoc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258531 17706 1 None -8 2 Mouse 5.2 pIC50 = 5.2 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccoc3)nc2c1 10.1016/j.bmcl.2010.08.014
24969872 17669 0 None 10 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258423 17669 0 None 10 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
24969527 17781 0 None 77 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccnc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258759 17781 0 None 77 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccnc3)nc2c1 10.1016/j.bmcl.2010.08.014
52941296 17320 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 456 6 1 3 6.7 Clc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257259 17320 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 456 6 1 3 6.7 Clc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52946355 17706 1 None 8 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccoc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258531 17706 1 None 8 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccoc3)nc2c1 10.1016/j.bmcl.2010.08.014
52950002 17743 0 None -16 2 Mouse 5.1 pIC50 = 5.1 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 446 7 1 3 6.0 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccccc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258646 17743 0 None -16 2 Mouse 5.1 pIC50 = 5.1 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 446 7 1 3 6.0 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccccc3)nc2c1 10.1016/j.bmcl.2010.08.014
52946277 17434 0 None 19 2 Human 7.1 pIC50 = 7.1 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257612 17434 0 None 19 2 Human 7.1 pIC50 = 7.1 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2c1 10.1016/j.bmcl.2010.08.014
52941357 17605 0 None -7 2 Mouse 5.1 pIC50 = 5.1 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 390 7 1 5 5.3 COc1ccc(CNCc2cc3ccc(OC)cc3nc2-c2ccsc2)cc1 10.1016/j.bmcl.2010.08.014
CHEMBL1258196 17605 0 None -7 2 Mouse 5.1 pIC50 = 5.1 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 390 7 1 5 5.3 COc1ccc(CNCc2cc3ccc(OC)cc3nc2-c2ccsc2)cc1 10.1016/j.bmcl.2010.08.014
52941356 17604 0 None 4 2 Human 6.1 pIC50 = 6.1 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 374 6 1 4 5.6 COc1ccc2cc(CNCc3ccc(C)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258195 17604 0 None 4 2 Human 6.1 pIC50 = 6.1 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 374 6 1 4 5.6 COc1ccc2cc(CNCc3ccc(C)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52946134 17321 0 None -2 2 Mouse 5.0 pIC50 = 5.0 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 466 8 1 4 6.5 CCOc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257260 17321 0 None -2 2 Mouse 5.0 pIC50 = 5.0 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 466 8 1 4 6.5 CCOc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
26404327 17635 0 None 38 2 Human 7.0 pIC50 = 7.0 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 7 1 4 6.0 COc1ccc2cc(CNCCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258311 17635 0 None 38 2 Human 7.0 pIC50 = 7.0 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 7 1 4 6.0 COc1ccc2cc(CNCCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
221493 921 87 None 2 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
3096 921 87 None 2 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
609 921 87 None 2 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
CHEMBL205596 921 87 None 2 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
DB02659 921 87 None 2 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
10133 910 78 None -1 4 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
145714624 910 78 None -1 4 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
4361 910 78 None -1 4 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
608 910 78 None -1 4 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
CHEMBL240597 910 78 None -1 4 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
DB06777 910 78 None -1 4 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
31401 48109 80 None - 1 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C None
CHEMBL1551 48109 80 None - 1 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C None
222528 1368 81 None 144 2 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
4988 1368 81 None 144 2 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
610 1368 81 None 144 2 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
CHEMBL406393 1368 81 None 144 2 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
DB03619 1368 81 None 144 2 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
447715 196927 68 None 9 7 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O None
CHEMBL566315 196927 68 None 9 7 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O None
60166172 994 0 None 79 2 Human 9.4 pEC50 = 9.4 Functional
Assessed in a cAMP production assay in Jurkat cells expressing exogenous hGPBAR1.Assessed in a cAMP production assay in Jurkat cells expressing exogenous hGPBAR1.
Guide to Pharmacology 387 4 1 2 5.5 Fc1ccc(c(c1)C)N(C(=O)c1ccncc1C)Cc1cccc2c1cc([nH]2)C 25411721
9078 994 0 None 79 2 Human 9.4 pEC50 = 9.4 Functional
Assessed in a cAMP production assay in Jurkat cells expressing exogenous hGPBAR1.Assessed in a cAMP production assay in Jurkat cells expressing exogenous hGPBAR1.
Guide to Pharmacology 387 4 1 2 5.5 Fc1ccc(c(c1)C)N(C(=O)c1ccncc1C)Cc1cccc2c1cc([nH]2)C 25411721
60166172 994 0 None -79 2 Mouse 7.5 pEC50 = 7.5 Functional
Assessed in a cAMP production assay in Jurkat cells expressing exogenous mGPBAR1.Assessed in a cAMP production assay in Jurkat cells expressing exogenous mGPBAR1.
Guide to Pharmacology 387 4 1 2 5.5 Fc1ccc(c(c1)C)N(C(=O)c1ccncc1C)Cc1cccc2c1cc([nH]2)C 25411721
9078 994 0 None -79 2 Mouse 7.5 pEC50 = 7.5 Functional
Assessed in a cAMP production assay in Jurkat cells expressing exogenous mGPBAR1.Assessed in a cAMP production assay in Jurkat cells expressing exogenous mGPBAR1.
Guide to Pharmacology 387 4 1 2 5.5 Fc1ccc(c(c1)C)N(C(=O)c1ccncc1C)Cc1cccc2c1cc([nH]2)C 25411721
10198 2054 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Measured by TR-FRET assay.Measured by TR-FRET assay.
Guide to Pharmacology 471 6 2 6 4.1 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)CC[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)[C@@H](CCOS(=O)(=O)[O-])C 20631053
137321169 2054 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Measured by TR-FRET assay.Measured by TR-FRET assay.
Guide to Pharmacology 471 6 2 6 4.1 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)CC[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)[C@@H](CCOS(=O)(=O)[O-])C 20631053
23642339 2054 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Measured by TR-FRET assay.Measured by TR-FRET assay.
Guide to Pharmacology 471 6 2 6 4.1 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)CC[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)[C@@H](CCOS(=O)(=O)[O-])C 20631053
CHEMBL3306873 2054 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Measured by TR-FRET assay.Measured by TR-FRET assay.
Guide to Pharmacology 471 6 2 6 4.1 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)CC[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)[C@@H](CCOS(=O)(=O)[O-])C 20631053
11696 4108 0 None 31 2 Human 7.1 pEC50 = 7.1 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5
Guide to Pharmacology 528 5 1 3 8.5 C[C@]12C(CC[C@]3(C)[C@@H]1CC[C@H]1[C@@]3(C)CC[C@]3(C(=O)O)[C@@H]1[C@H](C(C)C)CC3)C(C)(C)[C@H](OC(=O)CCC)CC2 34406006
156587567 4108 0 None 31 2 Human 7.1 pEC50 = 7.1 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5
Guide to Pharmacology 528 5 1 3 8.5 C[C@]12C(CC[C@]3(C)[C@@H]1CC[C@H]1[C@@]3(C)CC[C@]3(C(=O)O)[C@@H]1[C@H](C(C)C)CC3)C(C)(C)[C@H](OC(=O)CCC)CC2 34406006
11697 972 0 None 134 2 Human 8.2 pEC50 = 8.2 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5
Guide to Pharmacology 543 4 3 4 6.8 CC1(C)[C@H](OC(=O)NC2CC2)CC[C@@]2(C)C1CC[C@]1(C)C2CCC2[C@@]1(C)CC[C@]1(C(=O)O)C2[C@H]([C@H](C)O)CC1 34406006
156304705 972 0 None 134 2 Human 8.2 pEC50 = 8.2 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5
Guide to Pharmacology 543 4 3 4 6.8 CC1(C)[C@H](OC(=O)NC2CC2)CC[C@@]2(C)C1CC[C@]1(C)C2CCC2[C@@]1(C)CC[C@]1(C(=O)O)C2[C@H]([C@H](C)O)CC1 34406006
11696 4108 0 None -31 2 Mouse 5.6 pEC50 = 5.6 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5
Guide to Pharmacology 528 5 1 3 8.5 C[C@]12C(CC[C@]3(C)[C@@H]1CC[C@H]1[C@@]3(C)CC[C@]3(C(=O)O)[C@@H]1[C@H](C(C)C)CC3)C(C)(C)[C@H](OC(=O)CCC)CC2 34406006
156587567 4108 0 None -31 2 Mouse 5.6 pEC50 = 5.6 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5
Guide to Pharmacology 528 5 1 3 8.5 C[C@]12C(CC[C@]3(C)[C@@H]1CC[C@H]1[C@@]3(C)CC[C@]3(C(=O)O)[C@@H]1[C@H](C(C)C)CC3)C(C)(C)[C@H](OC(=O)CCC)CC2 34406006
11697 972 0 None -134 2 Mouse 6.0 pEC50 = 6.0 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5
Guide to Pharmacology 543 4 3 4 6.8 CC1(C)[C@H](OC(=O)NC2CC2)CC[C@@]2(C)C1CC[C@]1(C)C2CCC2[C@@]1(C)CC[C@]1(C(=O)O)C2[C@H]([C@H](C)O)CC1 34406006
156304705 972 0 None -134 2 Mouse 6.0 pEC50 = 6.0 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5
Guide to Pharmacology 543 4 3 4 6.8 CC1(C)[C@H](OC(=O)NC2CC2)CC[C@@]2(C)C1CC[C@]1(C)C2CCC2[C@@]1(C)CC[C@]1(C(=O)O)C2[C@H]([C@H](C)O)CC1 34406006
10494 2916 81 None - 1 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 1 2 2 7.2 O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C 17825251
3306 2916 81 None - 1 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 1 2 2 7.2 O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C 17825251
CHEMBL168 2916 81 None - 1 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 1 2 2 7.2 O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C 17825251
3945 625 92 None - 1 Human 6.0 pEC50 = 6.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 19911773
64971 625 92 None - 1 Human 6.0 pEC50 = 6.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 19911773
CHEMBL269277 625 92 None - 1 Human 6.0 pEC50 = 6.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 19911773
DB12480 625 92 None - 1 Human 6.0 pEC50 = 6.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 19911773
45483949 3582 35 None 2 2 Mouse 6.1 pEC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 20014870
7048 3582 35 None 2 2 Mouse 6.1 pEC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 20014870
CHEMBL567640 3582 35 None 2 2 Mouse 6.1 pEC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 20014870
222528 1368 81 None 144 2 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
4988 1368 81 None 144 2 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
610 1368 81 None 144 2 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
CHEMBL406393 1368 81 None 144 2 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
DB03619 1368 81 None 144 2 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
118694559 1134 0 None -1 2 Mouse 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 470 7 0 6 4.3 COC1=C(C=CC=C1)COC(=O)C=2[C@@H](CC(N(C2C)C[C@@H]3OCCC3)=O)C=4C=NC(=CC4)Cl 37639383
12906 1134 0 None -1 2 Mouse 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 470 7 0 6 4.3 COC1=C(C=CC=C1)COC(=O)C=2[C@@H](CC(N(C2C)C[C@@H]3OCCC3)=O)C=4C=NC(=CC4)Cl 37639383
118694559 1134 0 None 1 2 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 470 7 0 6 4.3 COC1=C(C=CC=C1)COC(=O)C=2[C@@H](CC(N(C2C)C[C@@H]3OCCC3)=O)C=4C=NC(=CC4)Cl 37639383
12906 1134 0 None 1 2 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 470 7 0 6 4.3 COC1=C(C=CC=C1)COC(=O)C=2[C@@H](CC(N(C2C)C[C@@H]3OCCC3)=O)C=4C=NC(=CC4)Cl 37639383
221493 921 87 None 2 2 Human 5.0 pEC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
3096 921 87 None 2 2 Human 5.0 pEC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
609 921 87 None 2 2 Human 5.0 pEC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
CHEMBL205596 921 87 None 2 2 Human 5.0 pEC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
DB02659 921 87 None 2 2 Human 5.0 pEC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
10133 910 78 None -1 4 Human 5.4 pEC50 None 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
145714624 910 78 None -1 4 Human 5.4 pEC50 None 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
4361 910 78 None -1 4 Human 5.4 pEC50 None 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
608 910 78 None -1 4 Human 5.4 pEC50 None 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
CHEMBL240597 910 78 None -1 4 Human 5.4 pEC50 None 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
DB06777 910 78 None -1 4 Human 5.4 pEC50 None 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
611 2327 75 None 50 2 Human 7.5 pEC50 None 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
9903 2327 75 None 50 2 Human 7.5 pEC50 None 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
CHEMBL1478 2327 75 None 50 2 Human 7.5 pEC50 None 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
5755 20820 76 None - 1 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha releaseAgonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha release
Drug Central 360 2 3 5 1.6 C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO None
CHEMBL131 20820 76 None - 1 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha releaseAgonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha release
Drug Central 360 2 3 5 1.6 C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO None
93055 217722 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha releaseAgonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha release
Drug Central 458 4 2 6 3.5 CC(C)(C)CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]12C None




Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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DOI

89501446 139402 1 None - 0 Human 10.2 pEC50 = 10.2 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 8 6.7 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3793436 139402 1 None - 0 Human 10.2 pEC50 = 10.2 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 8 6.7 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
89501446 139402 1 None - 0 Mouse 10.2 pEC50 = 10.2 Binding
Agonist activity at mouse TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 8 6.7 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3793436 139402 1 None - 0 Mouse 10.2 pEC50 = 10.2 Binding
Agonist activity at mouse TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 8 6.7 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL5270816 193653 0 None - 0 Human 9.4 pEC50 = 9.4 Binding
Agonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP productionAgonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP production
ChEMBL 460 4 0 6 5.6 Cc1noc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1021/acs.jmedchem.5b00342
CHEMBL5286836 194623 0 None - 0 Mouse 9.2 pEC50 = 9.2 Binding
Inhibition of mouse TGR5Inhibition of mouse TGR5
ChEMBL 615 10 0 5 6.6 CN(CC[N+](C)(C)C)C(=O)CCc1cc(Cl)c(Oc2ccsc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acsmedchemlett.3c00001
CHEMBL5315434 194623 0 None - 0 Mouse 9.2 pEC50 = 9.2 Binding
Inhibition of mouse TGR5Inhibition of mouse TGR5
ChEMBL 615 10 0 5 6.6 CN(CC[N+](C)(C)C)C(=O)CCc1cc(Cl)c(Oc2ccsc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acsmedchemlett.3c00001
CHEMBL5290871 194516 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionAgonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP production
ChEMBL 476 7 2 4 5.9 Cc1cc(/C(C[C@H](c2ccc(C3C[C@@H]4C(C(=O)O)[C@@H]4C3)cc2)c2ccc(F)cc2F)=N\O)ccn1 10.1021/acs.jmedchem.5b00342
CHEMBL5284434 194255 0 None - 0 Human 8.9 pEC50 = 8.9 Binding
Agonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assayAgonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assay
ChEMBL 587 5 0 5 8.2 Fc1cccc(F)c1-c1ccncc1CN1C(c2ccco2)=NO[C@@H]1c1cc(C(F)(F)F)cc(C(F)(F)F)c1Cl 10.1021/acs.jmedchem.5b00342
89501666 139486 0 None - 0 Human 8.8 pEC50 = 8.8 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 572 11 0 8 7.0 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4C)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3794442 139486 0 None - 0 Human 8.8 pEC50 = 8.8 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 572 11 0 8 7.0 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4C)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
46195848 83011 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at GPBAR1 in human NCI-H716 cellsAgonist activity at GPBAR1 in human NCI-H716 cells
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.5b01875
CHEMBL2181246 83011 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at GPBAR1 in human NCI-H716 cellsAgonist activity at GPBAR1 in human NCI-H716 cells
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.5b01875
46195848 83011 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at TGR5 (unknown origin)Agonist activity at TGR5 (unknown origin)
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1016/j.ejmech.2013.07.050
CHEMBL2181246 83011 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at TGR5 (unknown origin)Agonist activity at TGR5 (unknown origin)
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1016/j.ejmech.2013.07.050
46195848 83011 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.5b00342
CHEMBL2181246 83011 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.5b00342
136239453 91613 0 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407946 91613 0 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)cc1 10.1016/j.bmcl.2013.06.017
447715 196927 68 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml400247k
CHEMBL566315 196927 68 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml400247k
1520267 167762 45 None - 0 Human 6.0 pEC50 = 6 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 500 8 0 8 1.8 COc1ccc(S(=O)(=O)N2CCCN(S(=O)(=O)c3ccc(OC)c(OC)c3)CC2)cc1OC 10.1021/acs.jmedchem.5b00342
CHEMBL4303545 167762 45 None - 0 Human 6.0 pEC50 = 6 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 500 8 0 8 1.8 COc1ccc(S(=O)(=O)N2CCCN(S(=O)(=O)c3ccc(OC)c(OC)c3)CC2)cc1OC 10.1021/acs.jmedchem.5b00342
10133 910 78 None - 1 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
145714624 910 78 None - 1 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
4361 910 78 None - 1 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
608 910 78 None - 1 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
CHEMBL240597 910 78 None - 1 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
DB06777 910 78 None - 1 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
136166852 91634 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2408107 91634 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136239453 91613 0 None - 0 Mouse 6.0 pEC50 = 6.0 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407946 91613 0 None - 0 Mouse 6.0 pEC50 = 6.0 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)cc1 10.1016/j.bmcl.2013.06.017
136166933 91615 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 394 5 1 3 5.6 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407949 91615 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 394 5 1 3 5.6 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
136166936 91604 0 None - 0 Mouse 6.9 pEC50 = 6.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407931 91604 0 None - 0 Mouse 6.9 pEC50 = 6.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
56602333 91607 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407934 91607 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
76328184 104218 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 391 4 3 3 4.6 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCN)[C@@H]2[C@@H]1O 10.1021/ml400247k
CHEMBL3098607 104218 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 391 4 3 3 4.6 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCN)[C@@H]2[C@@H]1O 10.1021/ml400247k
CHEMBL5286949 194365 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 455 4 0 5 5.0 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2COC2)c2ccccc21 10.1021/acs.jmedchem.5b00342
136166852 91634 0 None - 0 Mouse 6.9 pEC50 = 6.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2408107 91634 0 None - 0 Mouse 6.9 pEC50 = 6.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
58043414 91617 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 424 5 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407951 91617 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 424 5 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL5276894 193916 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assayAgonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assay
ChEMBL 535 5 0 5 7.4 Fc1ccccc1-c1ccncc1CN1C(c2ccco2)=NOC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b00342
136166955 91612 0 None - 0 Mouse 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 10.1016/j.bmcl.2013.06.017
CHEMBL2407945 91612 0 None - 0 Mouse 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 10.1016/j.bmcl.2013.06.017
89501608 139457 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 559 11 0 9 6.1 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cncn4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3794111 139457 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 559 11 0 9 6.1 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cncn4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136260512 91614 0 None - 0 Mouse 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 346 6 1 5 3.9 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccn2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407947 91614 0 None - 0 Mouse 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 346 6 1 5 3.9 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccn2)cc1 10.1016/j.bmcl.2013.06.017
66739980 139465 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at TGR5 in human STC1 cells assessed as increase in GLP-1 secretionAgonist activity at TGR5 in human STC1 cells assessed as increase in GLP-1 secretion
ChEMBL 514 8 0 5 7.4 COc1ccc(C(C)(C)c2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.5b00342
CHEMBL3794175 139465 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at TGR5 in human STC1 cells assessed as increase in GLP-1 secretionAgonist activity at TGR5 in human STC1 cells assessed as increase in GLP-1 secretion
ChEMBL 514 8 0 5 7.4 COc1ccc(C(C)(C)c2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.5b00342
CHEMBL5275304 193849 0 None - 0 Mouse 7.8 pEC50 = 7.8 Binding
Inhibition of mouse TGR5Inhibition of mouse TGR5
ChEMBL 1315 33 1 21 7.0 CC#CCn1c(N2CCC[C@H](NC(=O)CCOCCOCCOCCOCCOCCOCCN(C)C(=O)CCc3cc(Cl)c(Oc4ccncc4C(=O)N4CCN(C5CC5)c5ccccc54)cc3Cl)C2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C 10.1021/acsmedchemlett.3c00001
66739980 139465 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 514 8 0 5 7.4 COc1ccc(C(C)(C)c2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3794175 139465 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 514 8 0 5 7.4 COc1ccc(C(C)(C)c2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
45483949 3582 35 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml400247k
7048 3582 35 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml400247k
CHEMBL567640 3582 35 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml400247k
89501521 139425 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 8 6.7 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cccn4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3793859 139425 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 8 6.7 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cccn4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136166950 91602 0 None - 0 Mouse 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407929 91602 0 None - 0 Mouse 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
221493 921 87 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
3096 921 87 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
609 921 87 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
CHEMBL205596 921 87 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
DB02659 921 87 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
90644452 111664 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 336 3 1 4 3.2 CC(=O)c1cc(C(=O)N2CCN(C3CC3)c3ccccc32)ccc1O 10.1016/j.ejmech.2014.05.031
CHEMBL3286440 111664 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 336 3 1 4 3.2 CC(=O)c1cc(C(=O)N2CCN(C3CC3)c3ccccc32)ccc1O 10.1016/j.ejmech.2014.05.031
89501429 139359 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 517 10 0 7 6.4 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3793012 139359 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 517 10 0 7 6.4 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136167037 91620 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407954 91620 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136166859 91609 0 None - 0 Mouse 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407936 91609 0 None - 0 Mouse 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL5279619 194030 0 None - 0 Mouse 5.7 pEC50 = 5.7 Binding
Agonist activity at mouse TGR5Agonist activity at mouse TGR5
ChEMBL 398 3 0 3 5.5 O=C(c1cccnc1Oc1cccc(C(F)(F)F)c1)N1CCCc2ccccc21 10.1021/acs.jmedchem.5b00342
CHEMBL5268940 193587 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP productionAgonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP production
ChEMBL 390 4 2 2 5.8 CC(C[C@H](C)C(=O)O)[C@H]1CCC2C3CC[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@@]21C 10.1021/acs.jmedchem.5b00342
CHEMBL5286375 194342 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP productionAgonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP production
ChEMBL 403 4 0 4 5.9 Fc1ccc(-n2c(COc3cccc4cnccc34)nc3ccccc32)c(Cl)c1 10.1021/acs.jmedchem.5b00342
CHEMBL5270683 193643 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human TGR5 transfected in CHO-K1 cells assessed as increase in cAMP productionAgonist activity at human TGR5 transfected in CHO-K1 cells assessed as increase in cAMP production
ChEMBL 702 12 2 7 6.1 Cc1c(Cl)cccc1OCCCC(=O)N1CCCc2c(-c3cnn(Cc4c(F)cc(C(=O)NCCS(=O)(=O)O)cc4Cl)c3)cccc21 10.1021/acs.jmedchem.5b00342
136166936 91604 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407931 91604 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL5284578 194258 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human TGR5 transfected in CHO-K1 cells assessed as increase in cAMP productionAgonist activity at human TGR5 transfected in CHO-K1 cells assessed as increase in cAMP production
ChEMBL 584 11 2 5 5.2 Cc1c(Cl)cccc1OCCCC(=O)N1CCC(Cc2cccc(C(=O)NCCS(=O)(=O)O)c2)c2ccccc21 10.1021/acs.jmedchem.5b00342
136166966 91611 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407944 91611 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2013.06.017
46195848 83011 0 None - 0 Mouse 5.6 pEC50 = 5.6 Binding
Agonist activity at mouse TGR5Agonist activity at mouse TGR5
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.5b00342
CHEMBL2181246 83011 0 None - 0 Mouse 5.6 pEC50 = 5.6 Binding
Agonist activity at mouse TGR5Agonist activity at mouse TGR5
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.5b00342
CHEMBL5289884 194483 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at GPBAR1 in human NCI-H716 cellsAgonist activity at GPBAR1 in human NCI-H716 cells
ChEMBL 581 6 2 6 7.1 Cc1cc(NC(=O)c2cc(Cl)c(Oc3ncccc3C(=O)N3CCCc4ccccc43)cc2Cl)sc1C(=O)O 10.1021/acs.jmedchem.5b01875
56602333 91607 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407934 91607 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
136166845 91618 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 374 6 2 4 4.8 Cc1cc(/C(CC(c2ccc(C(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407952 91618 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 374 6 2 4 4.8 Cc1cc(/C(CC(c2ccc(C(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136166900 91610 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N/O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407938 91610 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N/O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
136167006 91616 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 408 5 1 3 5.9 Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407950 91616 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 408 5 1 3 5.9 Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136167004 91603 7 None - 0 Mouse 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407930 91603 7 None - 0 Mouse 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL5281639 194121 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionAgonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP production
ChEMBL 428 6 1 5 3.6 Cc1ccccc1[C@H](C/C(=N/O)C1CCC(=O)N(C)C1)c1ccc(S(C)(=O)=O)cc1 10.1021/acs.jmedchem.5b00342
136166841 91621 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3cccc(C(=O)O)c3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407955 91621 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3cccc(C(=O)O)c3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
90654587 109955 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nMAgonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nM
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234568 109955 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nMAgonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nM
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
58043589 91608 0 None - 0 Mouse 5.5 pEC50 = 5.5 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407935 91608 0 None - 0 Mouse 5.5 pEC50 = 5.5 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
127029731 139484 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 575 11 0 8 7.6 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-c4nccs4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3794424 139484 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 575 11 0 8 7.6 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-c4nccs4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136166933 91615 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 394 5 1 3 5.6 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407949 91615 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 394 5 1 3 5.6 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
58043236 91606 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407933 91606 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL5281159 194106 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse TGR5Agonist activity at mouse TGR5
ChEMBL 550 6 2 8 4.6 O=C(Nc1nnn[nH]1)c1cc(Cl)c(Oc2ncccc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.5b00342
17755103 198824 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at TGR5 (unknown origin)Agonist activity at TGR5 (unknown origin)
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O)C(=O)O 10.1021/acs.jmedchem.5b00342
CHEMBL583611 198824 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at TGR5 (unknown origin)Agonist activity at TGR5 (unknown origin)
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O)C(=O)O 10.1021/acs.jmedchem.5b00342
136166845 91618 0 None - 0 Mouse 5.4 pEC50 = 5.4 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 374 6 2 4 4.8 Cc1cc(/C(CC(c2ccc(C(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407952 91618 0 None - 0 Mouse 5.4 pEC50 = 5.4 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 374 6 2 4 4.8 Cc1cc(/C(CC(c2ccc(C(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
89501780 139475 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 492 10 0 6 6.5 COc1ccc(C(C)(C)c2cnc(SCCOc3ccccc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3794293 139475 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 492 10 0 6 6.5 COc1ccc(C(C)(C)c2cnc(SCCOc3ccccc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136260512 91614 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 346 6 1 5 3.9 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccn2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407947 91614 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 346 6 1 5 3.9 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccn2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL5279619 194030 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 398 3 0 3 5.5 O=C(c1cccnc1Oc1cccc(C(F)(F)F)c1)N1CCCc2ccccc21 10.1021/acs.jmedchem.5b00342
136167004 91603 7 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407930 91603 7 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL5278743 193994 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at TGR5 (unknown origin) expressed in CHO cells incubated for 0.5 hr by microplate reader based analysisAgonist activity at TGR5 (unknown origin) expressed in CHO cells incubated for 0.5 hr by microplate reader based analysis
ChEMBL 529 7 0 5 6.9 COc1cc(Cl)cc(N(CC23CCC(c4ccc(OC)c(C#N)c4)(CC2)CC3)C(=O)c2ccncc2C)c1 10.1021/acs.jmedchem.1c01017
136166859 91609 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407936 91609 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
56601732 91605 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407932 91605 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
90654600 110008 0 None - 0 Mouse 7.3 pEC50 = 7.3 Binding
Agonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nMAgonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nM
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234871 110008 0 None - 0 Mouse 7.3 pEC50 = 7.3 Binding
Agonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nMAgonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nM
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL5286406 194345 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at GPBAR1 in human NCI-H716 cellsAgonist activity at GPBAR1 in human NCI-H716 cells
ChEMBL 470 6 1 4 5.8 O=C(O)CCc1cc(Cl)c(Oc2ncccc2C(=O)N2CCCc3ccccc32)cc1Cl 10.1021/acs.jmedchem.5b01875
90644454 112232 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 413 5 0 5 4.7 CC(=O)c1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1016/j.ejmech.2014.05.031
CHEMBL3290739 112232 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 413 5 0 5 4.7 CC(=O)c1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1016/j.ejmech.2014.05.031
CHEMBL5268028 193546 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Agonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assayAgonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assay
ChEMBL 569 5 0 5 8.1 Fc1ccccc1-c1ccncc1CN1C(c2ccco2)=NOC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1Cl 10.1021/acs.jmedchem.5b00342
89501594 139398 0 None - 0 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 576 11 0 8 6.9 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3793388 139398 0 None - 0 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 576 11 0 8 6.9 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136166950 91602 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407929 91602 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL5272181 193713 0 None - 0 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionAgonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP production
ChEMBL 425 5 1 5 4.3 Cc1ccccc1[C@H](C/C(=N/O)c1ccc(=O)n(C)n1)c1ccc(Br)cc1 10.1021/acs.jmedchem.5b00342
56601732 91605 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407932 91605 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
136166866 91619 0 None - 0 Mouse 5.2 pEC50 = 5.2 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 388 7 2 4 4.7 Cc1cc(/C(CC(c2ccc(CC(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407953 91619 0 None - 0 Mouse 5.2 pEC50 = 5.2 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 388 7 2 4 4.7 Cc1cc(/C(CC(c2ccc(CC(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
155339364 182716 0 None - 0 Mouse 7.2 pEC50 = 7.2 Binding
Inhibition of mouse TGR5Inhibition of mouse TGR5
ChEMBL 583 11 6 8 1.9 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1021/acsmedchemlett.3c00001
CHEMBL4789628 182716 0 None - 0 Mouse 7.2 pEC50 = 7.2 Binding
Inhibition of mouse TGR5Inhibition of mouse TGR5
ChEMBL 583 11 6 8 1.9 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1021/acsmedchemlett.3c00001
58043236 91606 0 None - 0 Mouse 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407933 91606 0 None - 0 Mouse 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL5273781 193778 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at GPBAR1 in human NCI-H716 cellsAgonist activity at GPBAR1 in human NCI-H716 cells
ChEMBL 527 8 2 5 4.9 O=C(O)CNC(=O)CCc1cc(Cl)c(Oc2ncccc2C(=O)N2CCCc3ccccc32)cc1Cl 10.1021/acs.jmedchem.5b01875
CHEMBL5275121 193839 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at GPBAR1 in human NCI-H716 cellsAgonist activity at GPBAR1 in human NCI-H716 cells
ChEMBL 485 6 2 5 4.5 O=C(NCCO)c1cc(Cl)c(Oc2ncccc2C(=O)N2CCCc3ccccc32)cc1Cl 10.1021/acs.jmedchem.5b01875
CHEMBL5283173 194189 0 None - 0 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at TGR5 in human T-lymphocyte cells assessed as increase in cAMP productionAgonist activity at TGR5 in human T-lymphocyte cells assessed as increase in cAMP production
ChEMBL 603 7 0 5 6.7 CS(=O)(=O)c1ccc(CC2CCC(c3c(C(=O)N4CCC(c5ccc(F)cc5)C4)cnn3-c3ccc(F)cc3)CC2)cc1 10.1021/acs.jmedchem.5b00342
CHEMBL5280567 194075 0 None - 0 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionAgonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP production
ChEMBL 398 3 0 3 5.8 O=C(c1ccncc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.5b00342
89501494 139352 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 557 11 0 7 7.3 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cccc4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3792957 139352 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 557 11 0 7 7.3 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cccc4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136166866 91619 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 388 7 2 4 4.7 Cc1cc(/C(CC(c2ccc(CC(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407953 91619 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 388 7 2 4 4.7 Cc1cc(/C(CC(c2ccc(CC(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136166966 91611 0 None - 0 Mouse 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407944 91611 0 None - 0 Mouse 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2013.06.017
611 2327 75 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/ml400247k
9903 2327 75 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/ml400247k
CHEMBL1478 2327 75 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/ml400247k
CHEMBL5280905 194089 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Agonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP productionAgonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP production
ChEMBL 449 5 0 4 5.8 N#Cc1cc(F)ccc1N(C(=O)COc1cccc2cnccc12)c1ccc(F)cc1Cl 10.1021/acs.jmedchem.5b00342
136167006 91616 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 408 5 1 3 5.9 Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407950 91616 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 408 5 1 3 5.9 Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL5267358 193524 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionAgonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP production
ChEMBL 483 5 0 6 4.0 COc1cc(F)ccc1-c1ccnnc1N(C)C(=O)c1cc(C(F)(F)F)cc(S(C)(=O)=O)c1 10.1021/acs.jmedchem.5b00342
CHEMBL5281159 194106 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 550 6 2 8 4.6 O=C(Nc1nnn[nH]1)c1cc(Cl)c(Oc2ncccc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.5b00342
CHEMBL5274626 193823 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assayAgonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assay
ChEMBL 545 5 0 4 7.8 Fc1ccccc1-c1ccncc1CN1C(c2ccccc2)=NOC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b00342
136166955 91612 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 10.1016/j.bmcl.2013.06.017
CHEMBL2407945 91612 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 10.1016/j.bmcl.2013.06.017
58043414 91617 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 424 5 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407951 91617 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 424 5 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
89501844 139380 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 590 11 0 8 7.2 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3793168 139380 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 590 11 0 8 7.2 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
58043589 91608 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407935 91608 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
136166841 91621 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3cccc(C(=O)O)c3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407955 91621 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3cccc(C(=O)O)c3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL5286933 194363 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionAgonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP production
ChEMBL 565 6 0 6 4.2 COc1cc(F)ccc1-c1ccncc1N(C)C(=O)c1cc(C(F)(F)F)cc(S(=O)(=O)N2CC3(COC3)C2)c1 10.1021/acs.jmedchem.5b00342
CHEMBL5272787 193736 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionAgonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP production
ChEMBL 380 3 0 4 4.5 CN(C(=O)c1c(-c2ccc(F)cc2)nc2ncccn12)c1ccc(Cl)cc1 10.1021/acs.jmedchem.5b00342
136167037 91620 0 None - 0 Mouse 7.0 pEC50 = 7.0 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407954 91620 0 None - 0 Mouse 7.0 pEC50 = 7.0 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
90654600 110008 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assayAgonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assay
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234871 110008 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assayAgonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assay
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
5755 20820 76 None - 0 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha releaseAgonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha release
ChEMBL 360 2 3 5 1.6 C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO 10.1021/acsmedchemlett.5b00323
CHEMBL131 20820 76 None - 0 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha releaseAgonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha release
ChEMBL 360 2 3 5 1.6 C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO 10.1021/acsmedchemlett.5b00323
90654587 109955 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assayAgonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234568 109955 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assayAgonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q