Ligand source activities (1 row/activity)





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11656002 89787 27 None 61 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 484 3 0 3 5.8 O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm301071h
CHEMBL2181247 89787 27 None 61 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 484 3 0 3 5.8 O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm301071h
90644451 118988 0 None 3 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 459 4 0 5 6.2 Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290717 118988 0 None 3 2 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 459 4 0 5 6.2 Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71561754 94419 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 432 6 0 5 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C(C)C 10.1016/j.bmcl.2012.12.076
CHEMBL2336232 94419 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 432 6 0 5 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C(C)C 10.1016/j.bmcl.2012.12.076
126673452 167932 0 None 257 2 Mouse 9.5 pEC50 = 9.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 774 19 2 12 5.2 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4087611 167932 0 None 257 2 Mouse 9.5 pEC50 = 9.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 774 19 2 12 5.2 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4117342 167932 0 None 257 2 Mouse 9.5 pEC50 = 9.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 774 19 2 12 5.2 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71462787 89769 0 None 3 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.1 Cc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
CHEMBL2181229 89769 0 None 3 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.1 Cc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
155669602 188719 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 372 4 0 4 4.1 C[C@H](c1ccccc1)n1cncc1C(=O)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4779837 188719 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 372 4 0 4 4.1 C[C@H](c1ccccc1)n1cncc1C(=O)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
118577239 167762 0 None 60 2 Mouse 9.4 pEC50 = 9.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 623 13 1 9 6.0 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4060410 167762 0 None 60 2 Mouse 9.4 pEC50 = 9.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 623 13 1 9 6.0 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116055 167762 0 None 60 2 Mouse 9.4 pEC50 = 9.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 623 13 1 9 6.0 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71626699 118987 0 None 5 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 425 4 0 5 5.6 Cc1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290716 118987 0 None 5 2 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 425 4 0 5 5.6 Cc1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71455634 89767 0 None 4 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 473 4 0 4 6.5 O=C(c1cnccc1Oc1cc(Cl)c(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181227 89767 0 None 4 2 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 473 4 0 4 6.5 O=C(c1cnccc1Oc1cc(Cl)c(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
90654589 116735 0 None 1 2 Mouse 9.3 pEC50 = 9.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 543 7 1 8 2.5 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCN(C5COC5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234570 116735 0 None 1 2 Mouse 9.3 pEC50 = 9.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 543 7 1 8 2.5 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCN(C5COC5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
90654598 116783 0 None 21 2 Mouse 9.3 pEC50 = 9.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 9 2 8 4.4 COc1cc(C2CCN(c3cc(N4CC[C@H]4C(=O)NCCc4ccc(C#N)cc4)nc(C(F)(F)F)n3)CC2)ccc1C(=O)O 10.1021/jm401731q
CHEMBL3234869 116783 0 None 21 2 Mouse 9.3 pEC50 = 9.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 9 2 8 4.4 COc1cc(C2CCN(c3cc(N4CC[C@H]4C(=O)NCCc4ccc(C#N)cc4)nc(C(F)(F)F)n3)CC2)ccc1C(=O)O 10.1021/jm401731q
71462786 89768 0 None 3 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 413 4 0 4 5.4 Cc1cc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1C 10.1021/jm301071h
CHEMBL2181228 89768 0 None 3 2 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 413 4 0 4 5.4 Cc1cc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1C 10.1021/jm301071h
71450251 89766 28 None 8 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 4 0 4 5.1 Cc1ccc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
CHEMBL2181226 89766 28 None 8 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 4 0 4 5.1 Cc1ccc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
71461054 89771 0 None 3 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 467 5 0 4 6.4 CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
CHEMBL2181230 89771 0 None 3 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 467 5 0 4 6.4 CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
118576935 164729 0 None 43 2 Mouse 9.1 pEC50 = 9.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 485 8 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4084668 164729 0 None 43 2 Mouse 9.1 pEC50 = 9.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 485 8 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
118576930 165594 0 None 25 2 Mouse 9.1 pEC50 = 9.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 515 9 0 7 6.4 COc1cc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)ccc1F 10.1021/acs.jmedchem.6b01873
CHEMBL4094487 165594 0 None 25 2 Mouse 9.1 pEC50 = 9.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 515 9 0 7 6.4 COc1cc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)ccc1F 10.1021/acs.jmedchem.6b01873
156705093 188669 0 None 25 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 469 5 0 7 5.0 COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4779084 188669 0 None 25 2 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 469 5 0 7 5.0 COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
90644451 118988 0 None -3 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 459 4 0 5 6.2 Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290717 118988 0 None -3 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 459 4 0 5 6.2 Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71462787 89769 0 None -3 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.1 Cc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
CHEMBL2181229 89769 0 None -3 2 Mouse 9.0 pEC50 = 9.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.1 Cc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
90654589 116735 0 None -1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 543 7 1 8 2.5 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCN(C5COC5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234570 116735 0 None -1 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 543 7 1 8 2.5 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCN(C5COC5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
46232571 209393 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2010.01.003
CHEMBL612138 209393 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2010.01.003
118103672 171229 0 None 31 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 679 14 5 8 3.6 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4213913 171229 0 None 31 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 679 14 5 8 3.6 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
90654587 116732 0 None -1 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234568 116732 0 None -1 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90654597 116782 0 None 17 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 594 9 2 8 4.1 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(C(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234868 116782 0 None 17 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 594 9 2 8 4.1 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(C(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
90654600 116785 0 None 8 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234871 116785 0 None 8 2 Mouse 9.0 pEC50 = 9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
162645557 186453 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 323 4 0 3 3.9 C[C@H](c1ccccc1)n1cncc1C(=O)N(C)c1ccc(F)cc1 10.1016/j.bmc.2020.115972
CHEMBL4743463 186453 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 323 4 0 3 3.9 C[C@H](c1ccccc1)n1cncc1C(=O)N(C)c1ccc(F)cc1 10.1016/j.bmc.2020.115972
162669860 189524 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 378 4 0 4 3.6 C[C@H](c1ccccc1)n1cncc1C(=O)N1CCN(c2ccccc2F)CC1 10.1016/j.bmc.2020.115972
CHEMBL4790044 189524 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 378 4 0 4 3.6 C[C@H](c1ccccc1)n1cncc1C(=O)N1CCN(c2ccccc2F)CC1 10.1016/j.bmc.2020.115972
71561753 94418 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 418 6 0 5 4.9 CCN(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL2336231 94418 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 418 6 0 5 4.9 CCN(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
71561756 94420 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 446 6 0 5 5.6 Cc1ccc(CN(C(=O)c2c(C)nn(C)c2Oc2cccc(Cl)c2Cl)C(C)C)cn1 10.1016/j.bmcl.2012.12.076
CHEMBL2336233 94420 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 446 6 0 5 5.6 Cc1ccc(CN(C(=O)c2c(C)nn(C)c2Oc2cccc(Cl)c2Cl)C(C)C)cn1 10.1016/j.bmcl.2012.12.076
71599441 170332 0 None 109 2 Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4202981 170332 0 None 109 2 Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
71599441 170332 0 None 109 2 Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4202981 170332 0 None 109 2 Mouse 8.9 pEC50 = 8.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
71626700 118986 0 None 7 2 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 445 4 0 5 5.9 O=C(c1cnccc1Oc1cc2ccoc2cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290715 118986 0 None 7 2 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 445 4 0 5 5.9 O=C(c1cnccc1Oc1cc2ccoc2cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
71626488 118984 0 None 3 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 426 4 0 6 5.0 Cc1noc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290713 118984 0 None 3 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 426 4 0 6 5.0 Cc1noc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
53311869 89780 0 None 3 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181239 89780 0 None 3 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
89501409 168139 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 6 7.5 COc1ccc(C(C)(C)c2cnc(SCCOCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL4126062 168139 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 6 7.5 COc1ccc(C(C)(C)c2cnc(SCCOCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
71540074 94067 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 453 7 2 6 3.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(SC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331649 94067 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 453 7 2 6 3.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(SC(F)(F)F)cc1)CC2 10.1021/ml300277t
77845059 118991 0 None 22 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 517 6 0 7 6.1 CCOC(=O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290720 118991 0 None 22 2 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 517 6 0 7 6.1 CCOC(=O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71561755 94058 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 438 6 0 6 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cncs1)C(C)C 10.1016/j.bmcl.2012.12.076
CHEMBL2331604 94058 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 438 6 0 6 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cncs1)C(C)C 10.1016/j.bmcl.2012.12.076
76314787 112799 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 382 5 0 5 4.1 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(Cl)cc2)c1 10.1039/C2MD20174G
CHEMBL3132966 112799 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 382 5 0 5 4.1 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(Cl)cc2)c1 10.1039/C2MD20174G
118103698 170451 0 None 12 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 724 15 5 10 2.5 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4204655 170451 0 None 12 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 724 15 5 10 2.5 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118093476 170882 0 None 39 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 780 14 6 13 2.1 Cn1c(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4209669 170882 0 None 39 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 780 14 6 13 2.1 Cn1c(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118104387 170891 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 718 15 4 8 3.0 O=C(O)CNC(=O)CNC(=O)CNC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4209799 170891 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 718 15 4 8 3.0 O=C(O)CNC(=O)CNC(=O)CNC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
145974037 171533 0 None 15 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 725 15 7 10 1.9 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4217797 171533 0 None 15 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 725 15 7 10 1.9 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4212707 220051 0 None - 1 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL None None None O=C(O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CCC(NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O)C(=O)NCC(=O)O)NC(=O)CCC(NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
91972025 162737 0 None 43 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 540 7 0 5 7.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4061329 162737 0 None 43 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 540 7 0 5 7.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
46195848 89786 0 None 257 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
CHEMBL2181246 89786 0 None 257 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
46232694 207692 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 5 0 3 5.9 CCCc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601637 207692 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 5 0 3 5.9 CCCc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232696 208319 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 5 0 3 5.9 CCc1onc(-c2ccccc2Cl)c1C(=O)N(CC)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL605367 208319 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 5 0 3 5.9 CCc1onc(-c2ccccc2Cl)c1C(=O)N(CC)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
76318386 112802 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 391 4 0 5 4.3 COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
CHEMBL3132969 112802 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 391 4 0 5 4.3 COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
118093484 170302 0 None 31 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 617 8 1 8 5.6 Cn1c(C(=O)O)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4202656 170302 0 None 31 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 617 8 1 8 5.6 Cn1c(C(=O)O)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118093390 170649 0 None 19 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4206832 170649 0 None 19 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
118093562 170666 0 None 5 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 547 9 1 5 5.7 O=C(O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4207005 170666 0 None 5 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 547 9 1 5 5.7 O=C(O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118103738 170667 0 None - 1 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 669 12 4 6 5.0 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCP(=O)(O)O 10.1021/acs.jmedchem.8b00308
CHEMBL4207008 170667 0 None - 1 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 669 12 4 6 5.0 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCP(=O)(O)O 10.1021/acs.jmedchem.8b00308
118103697 170736 0 None 7 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4207801 170736 0 None 7 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118103728 170782 0 None - 1 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 853 20 7 12 1.8 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CC[C@H](NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
CHEMBL4208317 170782 0 None - 1 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 853 20 7 12 1.8 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CC[C@H](NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
71661092 170831 0 None 10 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 665 13 5 8 3.2 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4208999 170831 0 None 10 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 665 13 5 8 3.2 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
118103732 170865 0 None - 1 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 648 14 2 7 5.1 O=C(O)CN(CCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)CC(=O)O 10.1021/acs.jmedchem.8b00308
CHEMBL4209515 170865 0 None - 1 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 648 14 2 7 5.1 O=C(O)CN(CCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)CC(=O)O 10.1021/acs.jmedchem.8b00308
71626700 118986 0 None -7 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 445 4 0 5 5.9 O=C(c1cnccc1Oc1cc2ccoc2cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290715 118986 0 None -7 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 445 4 0 5 5.9 O=C(c1cnccc1Oc1cc2ccoc2cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
90654593 116745 0 None 2 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 530 7 2 7 3.2 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(C(=O)O)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234580 116745 0 None 2 2 Mouse 8.0 pEC50 = 8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 530 7 2 7 3.2 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(C(=O)O)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
164613236 191285 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 541 4 2 3 8.1 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4847424 191285 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 541 4 2 3 8.1 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
155339362 179867 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 459 5 1 3 5.7 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N3CCCC3)[C@@H]21 10.1021/acs.jmedchem.9b00770
CHEMBL4519993 179867 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 459 5 1 3 5.7 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N3CCCC3)[C@@H]21 10.1021/acs.jmedchem.9b00770
71626492 118977 0 None 2 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2occc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290706 118977 0 None 2 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2occc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
168288290 198133 0 None 95 2 Human 7.0 pEC50 = 7 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 307 6 0 3 5.0 CCC(C)Oc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5192002 198133 0 None 95 2 Human 7.0 pEC50 = 7 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 307 6 0 3 5.0 CCC(C)Oc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
156016578 184485 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 399 4 2 3 5.5 C=CC[C@@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4642126 184485 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 399 4 2 3 5.5 C=CC[C@@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
118093575 170407 1 None -6 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 463 4 1 5 4.6 O=C([C@@H]1CSCN1Cc1cc(Cl)c(O)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4203848 170407 1 None -6 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 463 4 1 5 4.6 O=C([C@@H]1CSCN1Cc1cc(Cl)c(O)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118103679 170727 0 None -39 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
CHEMBL4207707 170727 0 None -39 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
118103700 170762 0 None -3 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 764 14 6 13 1.4 Cn1nc(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cc1OCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4208057 170762 0 None -3 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 764 14 6 13 1.4 Cn1nc(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cc1OCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
71661092 170831 0 None -10 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 665 13 5 8 3.2 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4208999 170831 0 None -10 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 665 13 5 8 3.2 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
118103668 171186 0 None -7 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 741 16 7 11 1.8 O=C(NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4213391 171186 0 None -7 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 741 16 7 11 1.8 O=C(NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
145972818 171421 0 None -3 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 734 13 6 12 1.3 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccn(Cc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)n1 10.1021/acs.jmedchem.8b00308
CHEMBL4216361 171421 0 None -3 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 734 13 6 12 1.3 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccn(Cc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)n1 10.1021/acs.jmedchem.8b00308
118103734 171429 0 None -25 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
CHEMBL4216584 171429 0 None -25 2 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
46233056 206159 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.9 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2010.01.003
CHEMBL590982 206159 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.9 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2010.01.003
73357024 99488 0 None -1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 471 5 1 3 6.4 N#CC(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435926 99488 0 None -1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 471 5 1 3 6.4 N#CC(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
71660979 170322 0 None -1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4202908 170322 0 None -1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
71660960 170369 0 None 1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
CHEMBL4203445 170369 0 None 1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
71661220 170400 0 None 1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4203777 170400 0 None 1 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
168280068 197968 0 None 5 2 Human 6.0 pEC50 = 6 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 293 6 0 3 4.6 CCCOc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5189181 197968 0 None 5 2 Human 6.0 pEC50 = 6 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 293 6 0 3 4.6 CCCOc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
44457490 164708 1 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 458 5 4 5 3.3 C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL408445 164708 1 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 458 5 4 5 3.3 C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
118093441 170551 0 None 1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 C[C@@]1(C(=O)N2CCN(C3CC3)c3ccccc32)CCCN1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4205745 170551 0 None 1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 C[C@@]1(C(=O)N2CCN(C3CC3)c3ccccc32)CCCN1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
71661224 170919 0 None -1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 415 4 0 3 4.6 O=C([C@@H]1CCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4210112 170919 0 None -1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 415 4 0 3 4.6 O=C([C@@H]1CCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
71660910 171036 0 None 1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 418 6 0 3 5.2 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CC1 10.1021/acs.jmedchem.8b00308
CHEMBL4211549 171036 0 None 1 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 418 6 0 3 5.2 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CC1 10.1021/acs.jmedchem.8b00308
46232410 207354 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 354 4 0 3 5.1 CCc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL599126 207354 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 354 4 0 3 5.1 CCc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
46232569 207901 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL603096 207901 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2010.01.003
71660910 171036 0 None -1 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 418 6 0 3 5.2 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CC1 10.1021/acs.jmedchem.8b00308
CHEMBL4211549 171036 0 None -1 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 418 6 0 3 5.2 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CC1 10.1021/acs.jmedchem.8b00308
89651284 171425 0 None -1 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 432 6 0 3 5.6 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CCC1 10.1021/acs.jmedchem.8b00308
CHEMBL4216520 171425 0 None -1 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 432 6 0 3 5.6 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CCC1 10.1021/acs.jmedchem.8b00308
45483949 10354 35 None -2 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2020.112619
7048 10354 35 None -2 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2020.112619
CHEMBL567640 10354 35 None -2 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2020.112619
439763 164905 22 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1039/d0md00425a
CHEMBL408701 164905 22 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1039/d0md00425a
90644448 119007 0 None -2 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 1 6 6.2 Cc1c(CCC(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
CHEMBL3290736 119007 0 None -2 2 Mouse 7.0 pEC50 = 7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 1 6 6.2 Cc1c(CCC(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
76314788 112800 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 383 5 0 6 3.5 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(Cl)cn2)c1 10.1039/C2MD20174G
CHEMBL3132967 112800 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 383 5 0 6 3.5 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(Cl)cn2)c1 10.1039/C2MD20174G
71561884 94423 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 430 6 0 5 5.0 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CC1 10.1016/j.bmcl.2012.12.076
CHEMBL2336236 94423 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 430 6 0 5 5.0 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CC1 10.1016/j.bmcl.2012.12.076
101886302 121688 36 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assayAgonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 5 3 3 5.0 CC[C@@H]1[C@H](O)[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCO)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/jm501273r
CHEMBL3342082 121688 36 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assayAgonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 5 3 3 5.0 CC[C@@H]1[C@H](O)[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCCO)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/jm501273r
136166966 98386 0 None 4 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 359 6 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407944 98386 0 None 4 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 359 6 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2013.06.017
3945 7412 92 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 10.1021/jm900872z
64971 7412 92 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 10.1021/jm900872z
CHEMBL269277 7412 92 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 10.1021/jm900872z
DB12480 7412 92 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 10.1021/jm900872z
9929677 164464 4 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 3 3 3 4.1 C[C@H](CC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL408175 164464 4 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 3 3 3 4.1 C[C@H](CC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
71561753 94418 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 418 6 0 5 4.9 CCN(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL2336231 94418 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 418 6 0 5 4.9 CCN(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
67922813 124453 1 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)O 10.1016/j.bmc.2015.01.048
CHEMBL3401352 124453 1 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)O 10.1016/j.bmc.2015.01.048
71561885 94424 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 460 6 0 6 4.7 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CCOC1 10.1016/j.bmcl.2012.12.076
CHEMBL2336237 94424 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 460 6 0 6 4.7 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CCOC1 10.1016/j.bmcl.2012.12.076
118464662 165918 0 None 22 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 687 16 0 8 7.3 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4097990 165918 0 None 22 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 687 16 0 8 7.3 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
73353937 99480 0 None -20 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 588 6 0 5 7.0 O=C(c1ccsc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435914 99480 0 None -20 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 588 6 0 5 7.0 O=C(c1ccsc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
94192 23794 19 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 388 4 1 3 4.9 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(=O)C[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.bmc.2015.01.048
CHEMBL1254261 23794 19 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 388 4 1 3 4.9 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C(=O)C[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.bmc.2015.01.048
90654598 116783 0 None -21 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 9 2 8 4.4 COc1cc(C2CCN(c3cc(N4CC[C@H]4C(=O)NCCc4ccc(C#N)cc4)nc(C(F)(F)F)n3)CC2)ccc1C(=O)O 10.1021/jm401731q
CHEMBL3234869 116783 0 None -21 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 9 2 8 4.4 COc1cc(C2CCN(c3cc(N4CC[C@H]4C(=O)NCCc4ccc(C#N)cc4)nc(C(F)(F)F)n3)CC2)ccc1C(=O)O 10.1021/jm401731q
76336516 112804 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 405 5 0 5 4.6 CCc1onc(-c2cccc(OC)c2)c1C(=O)N(C)c1ccc(C(F)(F)F)nc1 10.1039/C2MD20174G
CHEMBL3132970 112804 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 405 5 0 5 4.6 CCc1onc(-c2cccc(OC)c2)c1C(=O)N(C)c1ccc(C(F)(F)F)nc1 10.1039/C2MD20174G
90654585 116730 0 None -2 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 465 6 1 7 2.1 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)nc(N2CCN(C)CC2)c1F 10.1021/jm401731q
CHEMBL3234566 116730 0 None -2 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 465 6 1 7 2.1 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)nc(N2CCN(C)CC2)c1F 10.1021/jm401731q
71540073 94066 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 in human PBMC cells assessed as increase in intracellular cAMP measured after 1 hr by human whole blood assayAgonist activity at human TGR5 in human PBMC cells assessed as increase in intracellular cAMP measured after 1 hr by human whole blood assay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331648 94066 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 in human PBMC cells assessed as increase in intracellular cAMP measured after 1 hr by human whole blood assayAgonist activity at human TGR5 in human PBMC cells assessed as increase in intracellular cAMP measured after 1 hr by human whole blood assay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71626765 125602 0 None -2 2 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 539 8 0 6 6.3 CCOC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421893 125602 0 None -2 2 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 539 8 0 6 6.3 CCOC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
118586281 165342 0 None -7 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4091702 165342 0 None -7 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1 10.1021/acs.jmedchem.6b01873
126673489 163450 0 None -13 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 571 11 0 8 6.5 COC(=O)CCc1nc(SCc2c(F)cccc2F)n(-c2ccc(F)cc2)c1N(C)c1ccc(OC)c(OC)c1 10.1021/acs.jmedchem.6b01873
CHEMBL4069569 163450 0 None -13 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 571 11 0 8 6.5 COC(=O)CCc1nc(SCc2c(F)cccc2F)n(-c2ccc(F)cc2)c1N(C)c1ccc(OC)c(OC)c1 10.1021/acs.jmedchem.6b01873
71540174 94072 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 438 7 1 6 2.4 CCOc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331654 94072 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 438 7 1 6 2.4 CCOc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71561370 94405 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 424 4 0 5 5.2 Cc1ccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c(Cl)c1 10.1016/j.bmcl.2012.12.076
CHEMBL2336215 94405 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 424 4 0 5 5.2 Cc1ccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c(Cl)c1 10.1016/j.bmcl.2012.12.076
156705090 188486 0 None -54 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 497 7 0 7 5.8 CCCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4776876 188486 0 None -54 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 497 7 0 7 5.8 CCCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
164621408 192530 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 436 5 4 4 3.9 CC[C@H]1[C@@H](O)[C@@H]2[C@H](C[C@H](O)[C@H]3[C@H]2CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@]2(C)CC[C@@H](O)C[C@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4866257 192530 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 436 5 4 4 3.9 CC[C@H]1[C@@H](O)[C@@H]2[C@H](C[C@H](O)[C@H]3[C@H]2CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@]2(C)CC[C@@H](O)C[C@H]12 10.1021/acs.jmedchem.1c00851
137629931 167795 0 None 1 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 739 18 1 9 6.4 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)N(CCCO)CCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4064764 167795 0 None 1 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 739 18 1 9 6.4 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)N(CCCO)CCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4116312 167795 0 None 1 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 739 18 1 9 6.4 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)N(CCCO)CCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
155669593 190001 0 None 31 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 392 4 0 4 4.2 O=C(c1cncn1Cc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4796107 190001 0 None 31 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 392 4 0 4 4.2 O=C(c1cncn1Cc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
3035026 102559 41 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1021/jm7015864
CHEMBL258605 102559 41 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1021/jm7015864
73353943 99506 0 None -3 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 518 6 0 3 7.8 CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 10.1016/j.ejmech.2013.07.050
CHEMBL2435945 99506 0 None -3 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 518 6 0 3 7.8 CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 10.1016/j.ejmech.2013.07.050
90327533 119001 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 602 10 1 8 5.5 CCOC(=O)CNC(=O)CCc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290730 119001 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 602 10 1 8 5.5 CCOC(=O)CNC(=O)CCc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
126673464 165943 0 None - 1 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 556 12 1 7 6.6 COc1ccc(N(C)c2c(CCCCN)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4098315 165943 0 None - 1 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 556 12 1 7 6.6 COc1ccc(N(C)c2c(CCCCN)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71561368 94403 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2ccc(Cl)cc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336213 94403 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2ccc(Cl)cc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
118709772 120337 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 460 4 0 6 5.4 CSc1ncc(C(=O)N2CCN(C)c3ccccc32)c(Oc2cc(Cl)ccc2Cl)n1 10.1016/j.bmcl.2014.07.026
CHEMBL3321843 120337 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 460 4 0 6 5.4 CSc1ncc(C(=O)N2CCN(C)c3ccccc32)c(Oc2cc(Cl)ccc2Cl)n1 10.1016/j.bmcl.2014.07.026
71455632 89763 0 None 2 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 401 5 0 5 4.5 COc1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
CHEMBL2181223 89763 0 None 2 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 401 5 0 5 4.5 COc1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
71455633 89764 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 431 6 0 6 4.5 COc1ccc(OC)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
CHEMBL2181224 89764 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 431 6 0 6 4.5 COc1ccc(OC)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
71457418 89765 0 None 1 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 385 4 0 4 4.8 Cc1ccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1 10.1021/jm301071h
CHEMBL2181225 89765 0 None 1 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 385 4 0 4 4.8 Cc1ccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1 10.1021/jm301071h
90654594 116746 0 None -3 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 544 7 2 7 3.6 CC1(C(=O)O)CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234581 116746 0 None -3 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 544 7 2 7 3.6 CC1(C(=O)O)CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
118576974 163966 0 None 10 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3ccccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4075688 163966 0 None 10 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3ccccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
46232360 206094 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 496 3 0 3 6.4 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cc(Br)c(C)c(Br)c1 10.1016/j.bmcl.2010.01.003
CHEMBL590495 206094 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 496 3 0 3 6.4 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cc(Br)c(C)c(Br)c1 10.1016/j.bmcl.2010.01.003
46232566 207591 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccc(Cl)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL600821 207591 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccc(Cl)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232532 207665 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2cccc(Cl)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601441 207665 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2cccc(Cl)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232736 208087 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL604131 208087 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232567 208160 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccccc1-c1noc(C)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL604537 208160 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccccc1-c1noc(C)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
118103692 171175 0 None - 1 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 768 17 6 11 1.9 O=C(O)CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4213249 171175 0 None - 1 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 768 17 6 11 1.9 O=C(O)CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118103668 171186 0 None 7 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 741 16 7 11 1.8 O=C(NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4213391 171186 0 None 7 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 741 16 7 11 1.8 O=C(NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
44627312 205769 1 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 496 4 2 2 8.0 C=CC[C@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
CHEMBL585494 205769 1 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 496 4 2 2 8.0 C=CC[C@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
74766512 164226 0 None 3 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 699 17 0 9 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4079040 164226 0 None 3 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 699 17 0 9 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
118464638 166314 0 None 15 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 494 6 0 6 6.4 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4102357 166314 0 None 15 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 494 6 0 6 6.4 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
71720725 94426 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 428 4 0 5 5.1 Cc1nn(C)c(Oc2cccc(Cl)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336239 94426 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 428 4 0 5 5.1 Cc1nn(C)c(Oc2cccc(Cl)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
5284060 104270 11 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 4 3 3 4.4 C[C@H](CCCO)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL270287 104270 11 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 4 3 3 4.4 C[C@H](CCCO)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
73350995 99504 0 None 1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1ccsc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435943 99504 0 None 1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1ccsc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
90654577 116722 0 None 17 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1nccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234558 116722 0 None 17 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1nccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
156020210 184925 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 401 4 2 3 5.7 CCC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4648823 184925 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 401 4 2 3 5.7 CCC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
71626833 125605 0 None 1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 11 1 7 5.8 CCOC(=O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421897 125605 0 None 1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 11 1 7 5.8 CCOC(=O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
118735268 125612 0 None 2 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1398 41 2 18 10.9 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421904 125612 0 None 2 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1398 41 2 18 10.9 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
71626559 118979 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 410 4 1 4 5.0 O=C(c1cnccc1Oc1ccc2[nH]ccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290708 118979 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 410 4 1 4 5.0 O=C(c1cnccc1Oc1ccc2[nH]ccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
118721858 122866 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 389 3 1 3 3.3 CN1CCN(C(=O)C2(C(=O)Nc3cc(F)c(F)cc3F)CC2)c2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL3356914 122866 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 389 3 1 3 3.3 CN1CCN(C(=O)C2(C(=O)Nc3cc(F)c(F)cc3F)CC2)c2ccccc21 10.1016/j.bmcl.2014.07.026
164609554 191192 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 2 3 8.3 CC(C)NC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4846090 191192 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 2 3 8.3 CC(C)NC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
45483949 10354 35 None -2 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2013.07.050
7048 10354 35 None -2 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2013.07.050
CHEMBL567640 10354 35 None -2 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2013.07.050
73353944 99507 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 532 7 0 3 8.2 CCC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 10.1016/j.ejmech.2013.07.050
CHEMBL2435946 99507 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 532 7 0 3 8.2 CCC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 10.1016/j.ejmech.2013.07.050
118455158 164358 0 None 100 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1ccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4080612 164358 0 None 100 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1ccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
71599441 170332 0 None -109 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4202981 170332 0 None -109 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
118093493 170351 0 None 3 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 664 13 6 9 1.5 O=C(CCc1cc(Cl)c(CN2CCC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4203191 170351 0 None 3 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 664 13 6 9 1.5 O=C(CCc1cc(Cl)c(CN2CCC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
71660960 170369 0 None -1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
CHEMBL4203445 170369 0 None -1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
145978106 170604 0 None 1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 539 4 0 4 4.8 O=C([C@@H]1CSCN1Cc1cc(I)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4206320 170604 0 None 1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 539 4 0 4 4.8 O=C([C@@H]1CSCN1Cc1cc(I)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093410 171563 0 None 1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 465 4 0 3 5.2 O=C([C@@H]1CC(F)(F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4218210 171563 0 None 1 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 465 4 0 3 5.2 O=C([C@@H]1CC(F)(F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46233022 207543 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 452 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(I)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL600421 207543 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 452 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(I)cc1 10.1016/j.bmcl.2010.01.003
46233052 207570 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL600629 207570 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
145978106 170604 0 None -1 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 539 4 0 4 4.8 O=C([C@@H]1CSCN1Cc1cc(I)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4206320 170604 0 None -1 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 539 4 0 4 4.8 O=C([C@@H]1CSCN1Cc1cc(I)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093410 171563 0 None -1 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 465 4 0 3 5.2 O=C([C@@H]1CC(F)(F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4218210 171563 0 None -1 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 465 4 0 3 5.2 O=C([C@@H]1CC(F)(F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
222528 8150 81 None 144 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
4988 8150 81 None 144 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
610 8150 81 None 144 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
CHEMBL406393 8150 81 None 144 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
DB03619 8150 81 None 144 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
44372853 126673 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 CC(CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL349105 126673 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 CC(CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
118455158 164358 0 None -100 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 526 7 0 5 7.6 COc1ccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4080612 164358 0 None -100 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 526 7 0 5 7.6 COc1ccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
118455116 162971 0 None - 1 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 560 7 1 5 7.4 COc1cc(C2(CO)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4064131 162971 0 None - 1 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 560 7 1 5 7.4 COc1cc(C2(CO)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
46232658 206307 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 346 3 0 3 4.9 CN(C(=O)c1conc1-c1ccccc1Cl)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL592158 206307 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 346 3 0 3 4.9 CN(C(=O)c1conc1-c1ccccc1Cl)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232412 207355 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 368 4 0 3 5.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(C)C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL599127 207355 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 368 4 0 3 5.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(C)C)cc1 10.1016/j.bmcl.2010.01.003
46232875 207542 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1cccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)c1 10.1016/j.bmcl.2010.01.003
CHEMBL600410 207542 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1cccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)c1 10.1016/j.bmcl.2010.01.003
46233024 207544 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1cccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)c1 10.1016/j.bmcl.2010.01.003
CHEMBL600422 207544 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1cccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)c1 10.1016/j.bmcl.2010.01.003
46232597 208012 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2ccc(C(F)(F)F)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL603706 208012 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2ccc(C(F)(F)F)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
118093441 170551 0 None -1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 C[C@@]1(C(=O)N2CCN(C3CC3)c3ccccc32)CCCN1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4205745 170551 0 None -1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 C[C@@]1(C(=O)N2CCN(C3CC3)c3ccccc32)CCCN1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
71661223 171212 0 None 1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4213705 171212 0 None 1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232488 208356 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 368 4 0 4 4.8 CC(=O)c1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL605554 208356 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 368 4 0 4 4.8 CC(=O)c1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
71452077 89775 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 400 3 0 4 5.2 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCOc2ccccc21 10.1021/jm301071h
CHEMBL2181234 89775 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 400 3 0 4 5.2 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCOc2ccccc21 10.1021/jm301071h
73347898 99497 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 466 6 0 2 6.7 CCC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435935 99497 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 466 6 0 2 6.7 CCC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
118576974 163966 0 None -10 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3ccccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4075688 163966 0 None -10 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3ccccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
156705100 189028 0 None 4 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 567 7 0 10 5.5 Cc1oc(=O)oc1COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4783601 189028 0 None 4 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 567 7 0 10 5.5 Cc1oc(=O)oc1COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
3223370 116711 2 None -1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)C1CCCN(c2ncccn2)C1 10.1021/jm401731q
CHEMBL3234546 116711 2 None -1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)C1CCCN(c2ncccn2)C1 10.1021/jm401731q
90654580 116725 0 None 4 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 367 5 1 5 2.4 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)ncc1F 10.1021/jm401731q
CHEMBL3234561 116725 0 None 4 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 367 5 1 5 2.4 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)ncc1F 10.1021/jm401731q
90644457 119005 0 None 2 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 8 2 8 4.9 Cc1c(/C=C/C(=O)NCC(=O)O)oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
CHEMBL3290734 119005 0 None 2 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 8 2 8 4.9 Cc1c(/C=C/C(=O)NCC(=O)O)oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
90654588 116733 0 None 1 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 2 7 2.4 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234569 116733 0 None 1 2 Mouse 7.9 pEC50 = 7.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 2 7 2.4 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
164611903 191919 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 529 4 2 3 7.9 CCNC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4856750 191919 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 529 4 2 3 7.9 CCNC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
164621055 192716 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 541 4 2 4 7.0 CC(=O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4869294 192716 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 541 4 2 4 7.0 CC(=O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
11656002 89787 27 None -61 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 484 3 0 3 5.8 O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2181247 89787 27 None -61 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 484 3 0 3 5.8 O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
90654581 116726 0 None -7 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3nccc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234562 116726 0 None -7 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3nccc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
45483949 10354 35 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmcl.2013.06.017
7048 10354 35 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmcl.2013.06.017
CHEMBL567640 10354 35 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmcl.2013.06.017
118735267 125611 0 None 1 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1310 35 2 16 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421903 125611 0 None 1 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1310 35 2 16 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
164609009 191203 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 570 5 2 5 7.4 CO/N=C(/C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4846185 191203 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 570 5 2 5 7.4 CO/N=C(/C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
1434463 164524 5 None 1 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 404 4 0 6 4.4 CCn1c(=O)c2ccccc2n2c(SCc3ccc(C(F)(F)F)cc3)nnc12 10.1021/acs.jmedchem.6b01873
CHEMBL4082345 164524 5 None 1 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 404 4 0 6 4.4 CCn1c(=O)c2ccccc2n2c(SCc3ccc(C(F)(F)F)cc3)nnc12 10.1021/acs.jmedchem.6b01873
45483949 10354 35 None 2 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmc.2020.115972
7048 10354 35 None 2 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmc.2020.115972
CHEMBL567640 10354 35 None 2 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmc.2020.115972
11165617 165656 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 404 3 3 3 4.3 C[C@H]([C@@H]1C[C@@H]1C(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL409511 165656 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 404 3 3 3 4.3 C[C@H]([C@@H]1C[C@@H]1C(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
118464622 165650 0 None 26 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 548 6 0 4 8.4 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4F)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4095058 165650 0 None 26 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 548 6 0 4 8.4 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4F)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
118464720 163883 0 None - 1 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 598 6 0 4 9.2 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(C(F)(F)F)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4074596 163883 0 None - 1 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 598 6 0 4 9.2 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(C(F)(F)F)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
76332905 112806 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 391 4 0 6 3.2 COc1cccc(-c2nnn(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
CHEMBL3132972 112806 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 391 4 0 6 3.2 COc1cccc(-c2nnn(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
77845211 118996 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 503 6 1 6 5.5 O=C(O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290725 118996 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 503 6 1 6 5.5 O=C(O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
221493 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
3096 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
609 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
CHEMBL205596 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
DB02659 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
221493 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
3096 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
609 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
CHEMBL205596 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
DB02659 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
221493 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm901390p
3096 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm901390p
609 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm901390p
CHEMBL205596 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm901390p
DB02659 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm901390p
221493 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
3096 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
609 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
CHEMBL205596 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
DB02659 7708 87 None 2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
10140 167116 59 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 465 6 5 5 2.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL411070 167116 59 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 465 6 5 5 2.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
156705083 189875 0 None 10 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 557 8 0 10 5.5 CCOC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4794523 189875 0 None 10 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 557 8 0 10 5.5 CCOC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
71541723 94065 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 383 7 2 6 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC)cc1)CC2 10.1021/ml300277t
CHEMBL2331647 94065 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 383 7 2 6 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC)cc1)CC2 10.1021/ml300277t
156705119 189893 0 None -29 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 499 7 0 8 5.0 COCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4794753 189893 0 None -29 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 499 7 0 8 5.0 COCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
90654576 116721 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccncn2)C1 10.1021/jm401731q
CHEMBL3234557 116721 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccncn2)C1 10.1021/jm401731q
156705083 189875 0 None -10 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 557 8 0 10 5.5 CCOC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4794523 189875 0 None -10 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 557 8 0 10 5.5 CCOC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
130361963 177926 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 387 4 1 3 5.6 CO[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCC#N)[C@@H]3[C@H](O)C[C@@H]2C1 10.1021/acs.jmedchem.9b00770
CHEMBL4458539 177926 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 387 4 1 3 5.6 CO[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCC#N)[C@@H]3[C@H](O)C[C@@H]2C1 10.1021/acs.jmedchem.9b00770
71561883 94422 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 404 5 0 5 4.5 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(C)Cc1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336235 94422 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 404 5 0 5 4.5 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(C)Cc1cccnc1 10.1016/j.bmcl.2012.12.076
90654588 116733 0 None -1 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 2 7 2.4 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234569 116733 0 None -1 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 2 7 2.4 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
90654595 116747 0 None -7 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 636 10 2 8 4.6 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(Oc5ccc(CC(=O)O)cc5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234582 116747 0 None -7 2 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 636 10 2 8 4.6 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(Oc5ccc(CC(=O)O)cc5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
89501434 168176 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 542 11 0 6 6.9 COc1ccc(C(C)(C)c2cnc(SCCOCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL4126485 168176 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 542 11 0 6 6.9 COc1ccc(C(C)(C)c2cnc(SCCOCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
44427761 100002 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 420 4 3 3 5.0 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1[C@@H](C)[C@H]3O)C(=O)O 10.1021/jm070633p
CHEMBL244784 100002 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 420 4 3 3 5.0 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1[C@@H](C)[C@H]3O)C(=O)O 10.1021/jm070633p
90654582 116727 0 None -6 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ccnc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234563 116727 0 None -6 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ccnc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
90654569 116713 1 None -2 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234549 116713 1 None -2 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
58043589 98383 0 None 8 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407935 98383 0 None 8 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
118464804 163322 0 None -4 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 568 9 1 6 6.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(CCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4068168 163322 0 None -4 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 568 9 1 6 6.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(CCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
71561618 94414 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 457 4 0 4 6.5 Cc1ccccc1C1CCCCN1C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL2336226 94414 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 457 4 0 4 6.5 Cc1ccccc1C1CCCCN1C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
90654575 116720 0 None -1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 343 5 1 3 3.3 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccccn2)C1 10.1021/jm401731q
CHEMBL3234556 116720 0 None -1 2 Mouse 5.9 pEC50 = 5.9 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 343 5 1 3 3.3 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccccn2)C1 10.1021/jm401731q
118735266 125610 0 None 2 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1178 26 2 13 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421902 125610 0 None 2 2 Mouse 4.9 pEC50 = 4.9 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1178 26 2 13 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
90644460 118999 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 602 8 1 9 4.6 CCOC(=O)CNC(=O)c1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290728 118999 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 602 8 1 9 4.6 CCOC(=O)CNC(=O)c1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
118586281 165342 0 None 7 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4091702 165342 0 None 7 2 Mouse 6.9 pEC50 = 6.9 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1 10.1021/acs.jmedchem.6b01873
46232736 208087 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/ml300277t
CHEMBL604131 208087 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/ml300277t
46232736 208087 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1039/C2MD20174G
CHEMBL604131 208087 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1039/C2MD20174G
71599441 170332 0 None -109 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4202981 170332 0 None -109 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
156705091 188986 0 None -20 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 515 7 0 8 5.7 CSCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4783037 188986 0 None -20 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 515 7 0 8 5.7 CSCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
64945 65765 76 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 1 2 2 7.1 C[C@@H]1[C@H]2C3=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]4(C)[C@]3(C)CC[C@@]2(C(=O)O)CC[C@H]1C 10.1021/jm900872z
CHEMBL169 65765 76 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 1 2 2 7.1 C[C@@H]1[C@H]2C3=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]4(C)[C@]3(C)CC[C@@]2(C(=O)O)CC[C@H]1C 10.1021/jm900872z
156705115 188898 0 None 3 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 527 7 0 9 4.9 CC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4782069 188898 0 None 3 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 527 7 0 9 4.9 CC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
447718 104273 8 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CCCC[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL270311 104273 8 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CCCC[C@H]1C[C@H]3O 10.1021/jm7015864
71540076 94069 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 417 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331651 94069 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 417 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)cc1)CC2 10.1021/ml300277t
71561365 94400 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 410 4 0 5 4.9 Cc1nn(C)c(Oc2ccccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336210 94400 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 410 4 0 5 4.9 Cc1nn(C)c(Oc2ccccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
71540073 94066 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant TGR5 expressed in NCI-H716 cells assessed as increase in intracellular cAMP measured after 1 hrAgonist activity at human recombinant TGR5 expressed in NCI-H716 cells assessed as increase in intracellular cAMP measured after 1 hr
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331648 94066 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant TGR5 expressed in NCI-H716 cells assessed as increase in intracellular cAMP measured after 1 hrAgonist activity at human recombinant TGR5 expressed in NCI-H716 cells assessed as increase in intracellular cAMP measured after 1 hr
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71626558 118980 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 410 4 1 4 5.0 O=C(c1cnccc1Oc1cccc2[nH]ccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290709 118980 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 410 4 1 4 5.0 O=C(c1cnccc1Oc1cccc2[nH]ccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
71561369 94404 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cc(Cl)ccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336214 94404 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cc(Cl)ccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
11281589 124456 13 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 420 5 3 3 5.1 CC[C@H]1[C@H](O)[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCC(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
CHEMBL3401355 124456 13 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 420 5 3 3 5.1 CC[C@H]1[C@H](O)[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCC(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
71561365 94400 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 410 4 0 5 4.9 Cc1nn(C)c(Oc2ccccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336210 94400 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 410 4 0 5 4.9 Cc1nn(C)c(Oc2ccccc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
71561614 94406 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.3 Cc1nn(C)c(Oc2ccccc2C(F)(F)F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336216 94406 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.3 Cc1nn(C)c(Oc2ccccc2C(F)(F)F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
71626560 118983 0 None 3 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 428 4 0 6 5.1 O=C(c1cnccc1Oc1ccc2ncsc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290712 118983 0 None 3 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 428 4 0 6 5.1 O=C(c1cnccc1Oc1ccc2ncsc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
90654600 116785 0 None -8 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234871 116785 0 None -8 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
71457418 89765 0 None -1 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 385 4 0 4 4.8 Cc1ccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1 10.1021/jm301071h
CHEMBL2181225 89765 0 None -1 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 385 4 0 4 4.8 Cc1ccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1 10.1021/jm301071h
46233021 207593 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 404 3 0 3 5.3 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Br)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL600827 207593 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 404 3 0 3 5.3 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Br)cc1 10.1016/j.bmcl.2010.01.003
118093575 170407 1 None 6 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 463 4 1 5 4.6 O=C([C@@H]1CSCN1Cc1cc(Cl)c(O)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4203848 170407 1 None 6 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 463 4 1 5 4.6 O=C([C@@H]1CSCN1Cc1cc(Cl)c(O)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118104397 170952 0 None 15 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 750 14 6 12 2.2 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)o1 10.1021/acs.jmedchem.8b00308
CHEMBL4210547 170952 0 None 15 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 750 14 6 12 2.2 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)o1 10.1021/acs.jmedchem.8b00308
73352466 99486 0 None -4 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 453 5 1 3 6.3 N#CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435924 99486 0 None -4 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 453 5 1 3 6.3 N#CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
447715 203706 68 None 9 7 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acs.jmedchem.6b01126
CHEMBL566315 203706 68 None 9 7 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acs.jmedchem.6b01126
71626229 125609 0 None -2 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 9 1 6 5.3 CN(CC(=O)O)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421901 125609 0 None -2 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 9 1 6 5.3 CN(CC(=O)O)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
164628742 193349 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 595 4 2 3 9.6 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)Nc6ccc(F)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4878269 193349 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 595 4 2 3 9.6 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)Nc6ccc(F)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
118464786 163409 0 None - 1 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 530 6 0 4 8.2 COc1ccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4069164 163409 0 None - 1 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 530 6 0 4 8.2 COc1ccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1Cl 10.1021/acsmedchemlett.7b00116
24969872 24441 0 None 10 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1021/ml300277t
CHEMBL1258423 24441 0 None 10 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1021/ml300277t
71540075 94068 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 435 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331650 94068 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 435 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC(F)(F)F)cc1)CC2 10.1021/ml300277t
53311618 89790 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 3 0 4 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
CHEMBL2181251 89790 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 3 0 4 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
118586298 164805 0 None -2 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 449 8 0 6 6.1 COc1ccc(N(C)c2cnc(SCc3ccccc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4085664 164805 0 None -2 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 449 8 0 6 6.1 COc1ccc(N(C)c2cnc(SCc3ccccc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
10133 7697 78 None -1 4 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
145714624 7697 78 None -1 4 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
4361 7697 78 None -1 4 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
608 7697 78 None -1 4 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
CHEMBL240597 7697 78 None -1 4 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
DB06777 7697 78 None -1 4 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
71541719 94064 1 None 194 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
CHEMBL2331646 94064 1 None 194 3 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
44605616 205074 67 None 28 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayAgonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/jm901434t
CHEMBL575966 205074 67 None 28 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayAgonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/jm901434t
118093402 170999 0 None 1 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4211041 170999 0 None 1 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232529 207632 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2F)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601233 207632 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2F)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
118104385 170362 0 None 5 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 648 13 6 10 0.7 O=C(CCc1ccc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)c1)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4203321 170362 0 None 5 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 648 13 6 10 0.7 O=C(CCc1ccc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)c1)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
118464806 165836 0 None -34 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4097059 165836 0 None -34 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
71661222 171276 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 O=C([C@@H]1CCCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4214506 171276 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 O=C([C@@H]1CCCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
71660822 171544 0 None -5 2 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 461 4 0 4 4.9 O=C([C@@H]1CSCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4217961 171544 0 None -5 2 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 461 4 0 4 4.9 O=C([C@@H]1CSCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
71561504 94410 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@@H]1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336222 94410 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@@H]1c1cccnc1 10.1016/j.bmcl.2012.12.076
71626697 118982 0 None 3 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 427 4 0 5 5.7 O=C(c1cnccc1Oc1ccc2sccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290711 118982 0 None 3 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 427 4 0 5 5.7 O=C(c1cnccc1Oc1ccc2sccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
90644456 119002 0 None -1 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 557 7 0 7 6.8 CCOC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290731 119002 0 None -1 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 557 7 0 7 6.8 CCOC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
156705098 190173 2 None 12 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 513 8 0 8 5.4 CCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4798091 190173 2 None 12 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 513 8 0 8 5.4 CCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
137634612 162894 0 None 35 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 518 9 0 6 7.4 COc1ccc(SCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4063237 162894 0 None 35 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 518 9 0 6 7.4 COc1ccc(SCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
145955827 169461 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 504 5 4 4 4.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)N3CC[C@H](O)C3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4170310 169461 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 504 5 4 4 4.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)N3CC[C@H](O)C3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
71461057 89785 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 403 5 0 5 4.9 COc1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl 10.1021/jm301071h
CHEMBL2181244 89785 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 403 5 0 5 4.9 COc1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl 10.1021/jm301071h
76322065 112801 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 417 5 0 6 3.8 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
CHEMBL3132968 112801 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 417 5 0 6 3.8 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
90654573 116718 0 None -1 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 362 5 1 4 2.8 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncc(F)cn2)C1 10.1021/jm401731q
CHEMBL3234554 116718 0 None -1 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 362 5 1 4 2.8 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncc(F)cn2)C1 10.1021/jm401731q
90654565 116741 0 None 1 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234576 116741 0 None 1 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
136166950 98377 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407929 98377 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
130361811 163170 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 445 4 2 3 5.0 C[C@H](CCC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL4066443 163170 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 445 4 2 3 5.0 C[C@H](CCC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
71626491 118981 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 410 4 1 4 5.0 O=C(c1cnccc1Oc1ccc2cc[nH]c2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290710 118981 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 410 4 1 4 5.0 O=C(c1cnccc1Oc1ccc2cc[nH]c2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
71462788 89773 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 417 3 0 5 5.3 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 10.1021/jm301071h
CHEMBL2181232 89773 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 417 3 0 5 5.3 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 10.1021/jm301071h
9838552 198871 56 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 279 4 1 3 3.5 O=C(O)c1ccc(OCc2ccc3ccccc3n2)cc1 10.1021/acs.jmedchem.1c01078
CHEMBL5202995 198871 56 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 279 4 1 3 3.5 O=C(O)c1ccc(OCc2ccc3ccccc3n2)cc1 10.1021/acs.jmedchem.1c01078
45483949 10354 35 None -2 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml300277t
7048 10354 35 None -2 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml300277t
CHEMBL567640 10354 35 None -2 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml300277t
137641119 163788 0 None -28 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 636 12 0 8 6.2 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)/N=C/N(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4073356 163788 0 None -28 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 636 12 0 8 6.2 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)/N=C/N(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
77845060 118995 0 None -7 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 489 5 1 6 5.6 O=C(O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL3290724 118995 0 None -7 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 489 5 1 6 5.6 O=C(O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
1434463 164524 5 None -1 2 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 404 4 0 6 4.4 CCn1c(=O)c2ccccc2n2c(SCc3ccc(C(F)(F)F)cc3)nnc12 10.1021/acs.jmedchem.6b01873
CHEMBL4082345 164524 5 None -1 2 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 404 4 0 6 4.4 CCn1c(=O)c2ccccc2n2c(SCc3ccc(C(F)(F)F)cc3)nnc12 10.1021/acs.jmedchem.6b01873
71626489 118971 0 None 3 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 421 4 0 4 5.7 O=C(c1cnccc1Oc1cccc2ccccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290700 118971 0 None 3 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 421 4 0 4 5.7 O=C(c1cnccc1Oc1cccc2ccccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
90654581 116726 0 None 7 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3nccc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234562 116726 0 None 7 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3nccc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
90654592 116738 0 None 2 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 517 7 1 9 1.9 CCN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4cnc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234573 116738 0 None 2 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 517 7 1 9 1.9 CCN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4cnc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
118577298 167765 0 None 18 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4086463 167765 0 None 18 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4096633 167765 0 None 18 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116110 167765 0 None 18 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
66739980 146243 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 514 8 0 5 7.4 COc1ccc(C(C)(C)c2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL3794175 146243 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 514 8 0 5 7.4 COc1ccc(C(C)(C)c2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
89501851 168323 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 540 11 0 6 7.3 COc1ccc(C(C)(C)c2cnc(SCCOCc3cccc(Cl)c3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL4128655 168323 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 540 11 0 6 7.3 COc1ccc(C(C)(C)c2cnc(SCCOCc3cccc(Cl)c3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
164611905 191920 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 515 3 2 3 7.5 CNC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4856752 191920 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 515 3 2 3 7.5 CNC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
168277662 196951 1 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 321 7 0 3 5.2 CCC(C)COc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5173976 196951 1 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 321 7 0 3 5.2 CCC(C)COc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
58043414 98392 0 None 38 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 424 5 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407951 98392 0 None 38 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 424 5 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
90654586 116731 0 None 2 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1nc(N2CCN(C)CC2)cc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234567 116731 0 None 2 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1nc(N2CCN(C)CC2)cc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
71626833 125605 0 None -1 2 Mouse 4.8 pEC50 = 4.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 11 1 7 5.8 CCOC(=O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421897 125605 0 None -1 2 Mouse 4.8 pEC50 = 4.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 11 1 7 5.8 CCOC(=O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
101882379 121024 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assayAgonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assay
ChEMBL 420 6 3 3 5.3 C[C@H](CCCCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm500889f
CHEMBL3330019 121024 0 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assayAgonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assay
ChEMBL 420 6 3 3 5.3 C[C@H](CCCCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm500889f
52905075 165538 8 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 445 4 2 3 5.0 C[C@H](CCC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acs.jmedchem.9b00770
CHEMBL4093987 165538 8 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 445 4 2 3 5.0 C[C@H](CCC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acs.jmedchem.9b00770
164617191 191291 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 613 6 4 4 7.1 CC(C)[C@@H]1CC[C@]2(NC(=O)NCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4847526 191291 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 613 6 4 4 7.1 CC(C)[C@@H]1CC[C@]2(NC(=O)NCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
164608751 191232 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 567 4 3 4 8.1 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)Nc6cc[nH]n6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4846632 191232 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 567 4 3 4 8.1 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)Nc6cc[nH]n6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
10790510 108049 1 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 469 2 2 3 7.6 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL296302 108049 1 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 469 2 2 3 7.6 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
155669596 187448 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 358 4 0 4 3.6 O=C(c1cncn1Cc1ccccc1)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4755237 187448 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 358 4 0 4 3.6 O=C(c1cncn1Cc1ccccc1)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
118577298 167765 0 None -18 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4086463 167765 0 None -18 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4096633 167765 0 None -18 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116110 167765 0 None -18 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
121355127 169590 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 444 5 3 5 4.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCc3nn[nH]n3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4172477 169590 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 444 5 3 5 4.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCc3nn[nH]n3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
118709776 120341 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 389 3 2 3 4.2 O=C(Nc1cc(Cl)ccc1Cl)C1(C(=O)N2CCNc3ccccc32)CC1 10.1016/j.bmcl.2014.07.026
CHEMBL3321849 120341 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 389 3 2 3 4.2 O=C(Nc1cc(Cl)ccc1Cl)C1(C(=O)N2CCNc3ccccc32)CC1 10.1016/j.bmcl.2014.07.026
90644449 118976 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1cccc2cccnc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290705 118976 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1cccc2cccnc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
137646061 164594 0 None -3 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 502 9 0 6 6.7 COc1ccc(OCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4083324 164594 0 None -3 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 502 9 0 6 6.7 COc1ccc(OCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
71561885 94424 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 460 6 0 6 4.7 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CCOC1 10.1016/j.bmcl.2012.12.076
CHEMBL2336237 94424 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 460 6 0 6 4.7 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CCOC1 10.1016/j.bmcl.2012.12.076
90644444 119006 0 None 4 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 587 8 0 8 6.1 CCOC(=O)CCc1oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290735 119006 0 None 4 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 587 8 0 8 6.1 CCOC(=O)CCc1oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
90654597 116782 0 None -17 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 594 9 2 8 4.1 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(C(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234868 116782 0 None -17 2 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 594 9 2 8 4.1 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(C(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
90644458 119003 0 None 1 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 529 6 1 6 6.3 Cc1c(/C=C/C(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
CHEMBL3290732 119003 0 None 1 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 529 6 1 6 6.3 Cc1c(/C=C/C(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
53311869 89780 0 None -3 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181239 89780 0 None -3 2 Mouse 7.8 pEC50 = 7.8 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
164628005 193265 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 555 4 2 4 7.2 CC1(C)[C@H](OC(=O)NC2CC2)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@H]3[C@H]([C@@]4(C)CO4)CC[C@]3(C(=O)O)CC[C@]21C 10.1021/acs.jmedchem.1c00851
CHEMBL4877060 193265 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 555 4 2 4 7.2 CC1(C)[C@H](OC(=O)NC2CC2)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@H]3[C@H]([C@@]4(C)CO4)CC[C@]3(C(=O)O)CC[C@]21C 10.1021/acs.jmedchem.1c00851
118586282 166334 0 None 23 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 486 8 0 7 5.8 COc1ccc(N(C)c2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4102610 166334 0 None 23 2 Mouse 6.8 pEC50 = 6.8 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 486 8 0 7 5.8 COc1ccc(N(C)c2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
168270223 196844 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 321 8 0 3 5.4 CCCCCOc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5172427 196844 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 321 8 0 3 5.4 CCCCCOc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
6013 148648 49 None -575 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 288 0 1 2 3.9 C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
CHEMBL386630 148648 49 None -575 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 288 0 1 2 3.9 C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
137651596 163907 0 None - 1 Mouse 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 546 6 0 4 8.7 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(Cl)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4075062 163907 0 None - 1 Mouse 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 546 6 0 4 8.7 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(Cl)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
118464638 166314 0 None -15 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 494 6 0 6 6.4 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4102357 166314 0 None -15 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 494 6 0 6 6.4 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
11656002 89787 27 None 61 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 484 3 0 3 5.8 O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2181247 89787 27 None 61 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 484 3 0 3 5.8 O=C1COc2nccc(-c3ccccc3F)c2CN1Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
90654568 116744 0 None -4 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 7 1 8 1.8 CCN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)nc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234579 116744 0 None -4 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 7 1 8 1.8 CCN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)nc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
46232361 207285 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 354 3 0 3 5.2 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1C 10.1016/j.bmcl.2010.01.003
CHEMBL598743 207285 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 354 3 0 3 5.2 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1C 10.1016/j.bmcl.2010.01.003
46232414 207391 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL599328 207391 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2010.01.003
46232598 207737 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 326 3 0 3 4.6 Cc1onc(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601882 207737 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 326 3 0 3 4.6 Cc1onc(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232660 208043 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 4 0 3 6.0 CC(C)c1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL603921 208043 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 4 0 3 6.0 CC(C)c1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
90654583 116728 0 None -2 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1cc(N2CCN(C)CC2)nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234564 116728 0 None -2 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1cc(N2CCN(C)CC2)nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
130361919 163887 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 459 5 1 3 5.7 CO[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCC(=O)N4CCCC4)[C@@H]3[C@H](O)C[C@@H]2C1 10.1021/acs.jmedchem.9b00770
CHEMBL4074652 163887 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 459 5 1 3 5.7 CO[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCC(=O)N4CCCC4)[C@@H]3[C@H](O)C[C@@H]2C1 10.1021/acs.jmedchem.9b00770
387316 73543 48 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL185878 73543 48 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
126700763 165232 0 None - 1 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 557 11 1 7 6.4 COc1ccc(N(C)c2c(CCC(=O)O)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4090586 165232 0 None - 1 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 557 11 1 7 6.4 COc1ccc(N(C)c2c(CCC(=O)O)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
118103740 170333 0 None -25 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cn1 10.1021/acs.jmedchem.8b00308
CHEMBL4202994 170333 0 None -25 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cn1 10.1021/acs.jmedchem.8b00308
71661220 170400 0 None -1 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4203777 170400 0 None -1 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093390 170649 0 None -19 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4206832 170649 0 None -19 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
71661186 171061 0 None -3 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 532 9 1 5 5.6 NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4211892 171061 0 None -3 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 532 9 1 5 5.6 NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118093420 171324 0 None 1 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
CHEMBL4215113 171324 0 None 1 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
155528730 178158 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 469 5 3 5 3.5 C[C@H](CCC(=O)NS(C)(=O)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL4461961 178158 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 469 5 3 5 3.5 C[C@H](CCC(=O)NS(C)(=O)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
118093418 170874 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 O=C([C@H]1CCCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4209597 170874 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 O=C([C@H]1CCCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232986 207569 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccccc1Cl 10.1016/j.bmcl.2010.01.003
CHEMBL600624 207569 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccccc1Cl 10.1016/j.bmcl.2010.01.003
71661222 171276 0 None -1 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 O=C([C@@H]1CCCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4214506 171276 0 None -1 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 443 4 0 3 5.4 O=C([C@@H]1CCCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
44605616 205074 67 None -28 2 Rat 5.7 pEC50 = 5.7 Functional
Agonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/jm901434t
CHEMBL575966 205074 67 None -28 2 Rat 5.7 pEC50 = 5.7 Functional
Agonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/jm901434t
90654584 116729 0 None 1 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(C(F)(F)F)nc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)n2)CC1 10.1021/jm401731q
CHEMBL3234565 116729 0 None 1 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(C(F)(F)F)nc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)n2)CC1 10.1021/jm401731q
71540078 94071 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 422 6 1 5 2.6 CCc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331653 94071 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 422 6 1 5 2.6 CCc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71455634 89767 0 None -4 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 473 4 0 4 6.5 O=C(c1cnccc1Oc1cc(Cl)c(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181227 89767 0 None -4 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 473 4 0 4 6.5 O=C(c1cnccc1Oc1cc(Cl)c(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
90654566 116742 0 None 1 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 473 6 1 7 2.1 CN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234577 116742 0 None 1 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 473 6 1 7 2.1 CN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90654595 116747 0 None 7 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 636 10 2 8 4.6 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(Oc5ccc(CC(=O)O)cc5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234582 116747 0 None 7 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 636 10 2 8 4.6 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(Oc5ccc(CC(=O)O)cc5)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
90654596 116748 0 None 15 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 10 2 8 4.0 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(CC(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234583 116748 0 None 15 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 10 2 8 4.0 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(CC(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
90654599 116784 0 None 12 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 571 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc(-c4ccc(C(=O)O)cc4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234870 116784 0 None 12 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 571 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc(-c4ccc(C(=O)O)cc4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
118576958 165184 0 None 17 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 519 8 0 6 7.0 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)c(Cl)c2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4090147 165184 0 None 17 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 519 8 0 6 7.0 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)c(Cl)c2)cc1OC 10.1021/acs.jmedchem.6b01873
156705090 188486 0 None 54 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 497 7 0 7 5.8 CCCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4776876 188486 0 None 54 2 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 497 7 0 7 5.8 CCCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
76322064 112798 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 370 5 0 5 3.8 CCc1nnn(-c2cccc(OC)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1039/C2MD20174G
CHEMBL3132965 112798 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 370 5 0 5 3.8 CCc1nnn(-c2cccc(OC)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1039/C2MD20174G
71462786 89768 0 None -3 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 413 4 0 4 5.4 Cc1cc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1C 10.1021/jm301071h
CHEMBL2181228 89768 0 None -3 2 Mouse 8.7 pEC50 = 8.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 413 4 0 4 5.4 Cc1cc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1C 10.1021/jm301071h
71540073 94066 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1016/j.bmcl.2012.12.076
CHEMBL2331648 94066 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1016/j.bmcl.2012.12.076
145962358 168220 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 531 11 0 7 6.5 COc1ccc(C(C)(C)c2cnc(SCCOCc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL4127302 168220 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 531 11 0 7 6.5 COc1ccc(C(C)(C)c2cnc(SCCOCc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
71540073 94066 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331648 94066 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71461054 89771 0 None -3 2 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 467 5 0 4 6.4 CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
CHEMBL2181230 89771 0 None -3 2 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 467 5 0 4 6.4 CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm301071h
71561882 94421 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 446 7 0 5 5.7 CCC(C)N(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL2336234 94421 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 446 7 0 5 5.7 CCC(C)N(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
71626699 118987 0 None -5 2 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 425 4 0 5 5.6 Cc1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290716 118987 0 None -5 2 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 425 4 0 5 5.6 Cc1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71541719 94064 1 None 194 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
CHEMBL2331646 94064 1 None 194 3 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
118103679 170727 0 None 39 2 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
CHEMBL4207707 170727 0 None 39 2 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
118103737 171610 0 None - 1 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 738 12 3 7 5.1 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)N1CCN(CP(=O)(O)O)CC1 10.1021/acs.jmedchem.8b00308
CHEMBL4218746 171610 0 None - 1 Mouse 8.6 pEC50 = 8.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 738 12 3 7 5.1 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)N1CCN(CP(=O)(O)O)CC1 10.1021/acs.jmedchem.8b00308
71540076 94069 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 417 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331651 94069 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 417 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)cc1)CC2 10.1021/ml300277t
156705112 189643 0 None 15 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 483 6 0 7 5.4 CCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4791709 189643 0 None 15 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 483 6 0 7 5.4 CCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
71450252 89781 0 None 10 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.2 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181240 89781 0 None 10 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.2 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 10.1021/jm301071h
71540175 94073 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 434 6 1 5 2.9 NC(=O)c1nc(C2CC2)nc2c1CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331655 94073 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 434 6 1 5 2.9 NC(=O)c1nc(C2CC2)nc2c1CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
53311869 89780 0 None 3 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL2181239 89780 0 None 3 2 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
71452080 89795 0 None 10 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 440 4 0 5 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181256 89795 0 None 10 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 440 4 0 5 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
118709771 120305 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 429 3 2 6 4.3 CN1CCN(C(=O)c2cnc(O)nc2Nc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL3321758 120305 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 429 3 2 6 4.3 CN1CCN(C(=O)c2cnc(O)nc2Nc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
71452078 89791 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 428 4 0 5 5.1 CCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181252 89791 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 428 4 0 5 5.1 CCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
90654563 116739 0 None 1 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.8 CN1CCN(c2cc(N3CCCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234574 116739 0 None 1 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.8 CN1CCN(c2cc(N3CCCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
118576930 165594 0 None -25 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 515 9 0 7 6.4 COc1cc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)ccc1F 10.1021/acs.jmedchem.6b01873
CHEMBL4094487 165594 0 None -25 2 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 515 9 0 7 6.4 COc1cc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)ccc1F 10.1021/acs.jmedchem.6b01873
90655904 119583 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Transactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive element containing luciferase reporter gene assayTransactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive element containing luciferase reporter gene assay
ChEMBL 486 7 3 5 4.8 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCCOS(=O)(=O)O)[C@@H]2[C@@H]1O 10.1021/jm401873d
CHEMBL3260994 119583 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Transactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive element containing luciferase reporter gene assayTransactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive element containing luciferase reporter gene assay
ChEMBL 486 7 3 5 4.8 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCCOS(=O)(=O)O)[C@@H]2[C@@H]1O 10.1021/jm401873d
CHEMBL3306811 119583 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Transactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive element containing luciferase reporter gene assayTransactivation of human GP-BAR1 transfected in HEK293T cells assessed as induction of intracellular cAMP production after 18 hrs by cAMP responsive element containing luciferase reporter gene assay
ChEMBL 486 7 3 5 4.8 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCCOS(=O)(=O)O)[C@@H]2[C@@H]1O 10.1021/jm401873d
56601732 98380 0 None 1 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407932 98380 0 None 1 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
168276623 197190 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 295 4 2 4 3.2 O=C(O)c1cc(O)cc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5177797 197190 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 295 4 2 4 3.2 O=C(O)c1cc(O)cc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
118735267 125611 0 None -1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1310 35 2 16 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421903 125611 0 None -1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1310 35 2 16 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
447715 203706 68 None 9 7 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1016/j.bmc.2011.03.004
CHEMBL566315 203706 68 None 9 7 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1016/j.bmc.2011.03.004
73350992 99484 0 None 10 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 442 5 1 2 6.8 CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435921 99484 0 None 10 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 442 5 1 2 6.8 CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
73350992 99484 0 None -10 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 442 5 1 2 6.8 CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435921 99484 0 None -10 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 442 5 1 2 6.8 CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
118464724 166244 0 None -61 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 528 7 0 6 6.8 COc1ccc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4101442 166244 0 None -61 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 528 7 0 6 6.8 COc1ccc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
137651232 164147 0 None 20 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 570 10 1 9 6.1 COc1ccc(SCc2cnc(SCc3c(F)cc(-c4nn[nH]n4)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4077972 164147 0 None 20 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 570 10 1 9 6.1 COc1ccc(SCc2cnc(SCc3c(F)cc(-c4nn[nH]n4)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
137629931 167795 0 None -1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 739 18 1 9 6.4 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)N(CCCO)CCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4064764 167795 0 None -1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 739 18 1 9 6.4 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)N(CCCO)CCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4116312 167795 0 None -1 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 739 18 1 9 6.4 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)N(CCCO)CCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
44627311 204061 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 496 4 2 2 8.0 C=CC[C@@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
CHEMBL568584 204061 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 496 4 2 2 8.0 C=CC[C@@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
156705098 190173 2 None -12 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 513 8 0 8 5.4 CCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4798091 190173 2 None -12 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 513 8 0 8 5.4 CCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
66740913 165434 0 None 22 2 Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 471 8 0 6 5.6 COc1ccc(Cc2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4092629 165434 0 None 22 2 Mouse 7.7 pEC50 = 7.7 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 471 8 0 6 5.6 COc1ccc(Cc2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
89501422 168410 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 531 11 0 7 6.5 COc1ccc(C(C)(C)c2cnc(SCCOCc3cccc(C#N)c3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL4130025 168410 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 531 11 0 7 6.5 COc1ccc(C(C)(C)c2cnc(SCCOCc3cccc(C#N)c3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
118464747 165113 0 None 4 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 743 19 2 10 6.0 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)NCCOCCOCCOCCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4089352 165113 0 None 4 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 743 19 2 10 6.0 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)NCCOCCOCCOCCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
73357025 99493 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 568 7 0 3 7.3 O=S(=O)(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1)Cc1cnccc1-c1ccccc1F 10.1016/j.ejmech.2013.07.050
CHEMBL2435931 99493 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 568 7 0 3 7.3 O=S(=O)(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccccc1)Cc1cnccc1-c1ccccc1F 10.1016/j.ejmech.2013.07.050
90654577 116722 0 None -17 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1nccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234558 116722 0 None -17 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1nccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
156705085 189766 0 None -2 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 543 10 0 9 5.0 COCCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4793377 189766 0 None -2 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 543 10 0 9 5.0 COCCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
164628559 193325 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 1 3 8.3 CCN(C)C(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4877942 193325 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 1 3 8.3 CCN(C)C(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
71718878 94425 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1016/j.bmcl.2012.12.076
CHEMBL2336238 94425 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1016/j.bmcl.2012.12.076
71718878 94425 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1039/C2MD20174G
CHEMBL2336238 94425 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1039/C2MD20174G
118464713 166076 0 None - 1 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 516 6 0 5 6.9 COc1cc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4099616 166076 0 None - 1 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 516 6 0 5 6.9 COc1cc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
71541722 94063 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 381 7 2 5 2.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC)cc1)CC2 10.1021/ml300277t
CHEMBL2331645 94063 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 381 7 2 5 2.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC)cc1)CC2 10.1021/ml300277t
77845060 118995 0 None 7 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 489 5 1 6 5.6 O=C(O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL3290724 118995 0 None 7 2 Mouse 6.7 pEC50 = 6.7 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 489 5 1 6 5.6 O=C(O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
44337790 13859 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 458 2 2 2 7.2 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)C(CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C12 10.1021/jm900872z
CHEMBL108505 13859 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 458 2 2 2 7.2 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)C(CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C12 10.1021/jm900872z
90654572 116717 0 None 1 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ncccn3)C2)cc1 10.1021/jm401731q
CHEMBL3234553 116717 0 None 1 2 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ncccn3)C2)cc1 10.1021/jm401731q
137634963 162660 0 None -21 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 529 10 0 6 6.3 COc1ccc(N(C=O)Cc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4060463 162660 0 None -21 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 529 10 0 6 6.3 COc1ccc(N(C=O)Cc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
5284061 23748 15 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 4 3 3 4.4 C[C@H](CCCO)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL1253814 23748 15 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 4 3 3 4.4 C[C@H](CCCO)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
66737876 124452 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 390 4 2 2 5.8 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)O 10.1016/j.bmc.2015.01.048
CHEMBL3401351 124452 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 390 4 2 2 5.8 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)O 10.1016/j.bmc.2015.01.048
90654578 116723 0 None 3 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1cccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234559 116723 0 None 3 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1cccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
155534242 178702 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 430 4 2 5 4.9 Cc1nnc(CC[C@@H](C)[C@H]2CC[C@H]3[C@H]4[C@H](CC[C@@]32C)[C@@]2(C)CC[C@@H](O)C[C@H]2C[C@H]4O)o1 10.1021/acs.jmedchem.9b00770
CHEMBL4470072 178702 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 430 4 2 5 4.9 Cc1nnc(CC[C@@H](C)[C@H]2CC[C@H]3[C@H]4[C@H](CC[C@@]32C)[C@@]2(C)CC[C@@H](O)C[C@H]2C[C@H]4O)o1 10.1021/acs.jmedchem.9b00770
10494 9690 81 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 1 2 2 7.2 O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C 10.1021/jm900872z
3306 9690 81 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 1 2 2 7.2 O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C 10.1021/jm900872z
CHEMBL168 9690 81 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 456 1 2 2 7.2 O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C 10.1021/jm900872z
156019954 184774 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 385 3 2 3 5.1 C=C[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4646264 184774 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 385 3 2 3 5.1 C=C[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
164613461 191769 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 607 5 2 4 9.4 COc1ccc(NC(=O)O[C@@H]2CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3CC[C@@H]3[C@H]5[C@H](C(C)C)CC[C@]5(C(=O)O)CC[C@]34C)C2(C)C)cc1 10.1021/acs.jmedchem.1c00851
CHEMBL4854339 191769 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 607 5 2 4 9.4 COc1ccc(NC(=O)O[C@@H]2CC[C@@]3(C)[C@@H](CC[C@]4(C)[C@@H]3CC[C@@H]3[C@H]5[C@H](C(C)C)CC[C@]5(C(=O)O)CC[C@]34C)C2(C)C)cc1 10.1021/acs.jmedchem.1c00851
44457460 102890 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 394 4 2 2 5.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](F)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL260314 102890 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 394 4 2 2 5.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](F)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
44605617 205098 1 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL576138 205098 1 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1016/j.bmcl.2012.12.076
71452076 89772 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 454 4 0 5 5.6 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181231 89772 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 454 4 0 5 5.6 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 10.1021/jm301071h
90654582 116727 0 None 6 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ccnc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234563 116727 0 None 6 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 403 5 1 5 2.9 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ccnc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
156705093 188669 0 None -25 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 469 5 0 7 5.0 COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4779084 188669 0 None -25 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 469 5 0 7 5.0 COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
162665892 189104 0 None 16 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 537 6 0 7 6.0 O=C(OCC(F)(F)F)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4784355 189104 0 None 16 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 537 6 0 7 6.0 O=C(OCC(F)(F)F)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
73350995 99504 0 None -1 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1ccsc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435943 99504 0 None -1 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1ccsc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
137630517 167849 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 631 13 1 7 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4083747 167849 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 631 13 1 7 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4116717 167849 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 631 13 1 7 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
387316 73543 48 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1016/j.ejmech.2015.09.024
CHEMBL185878 73543 48 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1016/j.ejmech.2015.09.024
168281036 197735 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 281 4 2 4 3.0 OCc1cc(O)cc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5185938 197735 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 281 4 2 4 3.0 OCc1cc(O)cc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
71561366 94401 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336211 94401 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
44457491 103170 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 481 7 2 3 5.7 C[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL261826 103170 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 481 7 2 3 5.7 C[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@H]12 10.1021/jm7015864
118576918 167910 0 None -24 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 654 13 0 8 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4078612 167910 0 None -24 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 654 13 0 8 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4117224 167910 0 None -24 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 654 13 0 8 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
31401 54883 80 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.bmc.2015.01.048
CHEMBL1551 54883 80 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.bmc.2015.01.048
90644446 118993 0 None 3 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 559 7 0 8 5.4 COC(=O)CCc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290722 118993 0 None 3 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 559 7 0 8 5.4 COC(=O)CCc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
44605617 205098 1 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/ml300277t
CHEMBL576138 205098 1 None 5 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/ml300277t
118577239 167762 0 None -60 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 623 13 1 9 6.0 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4060410 167762 0 None -60 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 623 13 1 9 6.0 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116055 167762 0 None -60 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 623 13 1 9 6.0 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71459275 89776 0 None -7 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 427 4 0 4 5.7 CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181235 89776 0 None -7 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 427 4 0 4 5.7 CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
145956445 168864 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 505 6 3 5 5.2 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)O[C@H]3CCOC3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4160849 168864 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 505 6 3 5 5.2 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)O[C@H]3CCOC3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
145177795 169104 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 463 5 4 4 3.8 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)C(=O)O)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4164682 169104 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 463 5 4 4 3.8 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)C(=O)O)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
71626422 118985 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 426 4 0 6 5.0 Cc1noc2cc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)ccc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290714 118985 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 426 4 0 6 5.0 Cc1noc2cc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)ccc12 10.1016/j.ejmech.2014.05.031
119046 104313 40 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL270516 104313 40 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
71541723 94065 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 383 7 2 6 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC)cc1)CC2 10.1021/ml300277t
CHEMBL2331647 94065 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 383 7 2 6 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC)cc1)CC2 10.1021/ml300277t
134494 166524 21 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 292 0 2 2 3.8 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@H](O)CC[C@]34C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
CHEMBL410494 166524 21 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 292 0 2 2 3.8 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@H](O)CC[C@]34C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
5284305 121021 1 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assayAgonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assay
ChEMBL 364 3 3 3 4.0 C[C@H](CCO)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm500889f
CHEMBL3329940 121021 1 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assayAgonist activity at human GPBAR1 expressed in HEK293T cells assessed as stimulation of cAMP response element-mediated receptor transactivation by luciferase reporter gene assay
ChEMBL 364 3 3 3 4.0 C[C@H](CCO)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm500889f
137636348 162644 0 None 12 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 524 7 0 5 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4060315 162644 0 None 12 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 524 7 0 5 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
71626556 118978 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2ccoc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290707 118978 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2ccoc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
90644458 119003 0 None -1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 529 6 1 6 6.3 Cc1c(/C=C/C(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
CHEMBL3290732 119003 0 None -1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 529 6 1 6 6.3 Cc1c(/C=C/C(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
90654599 116784 0 None -12 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 571 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc(-c4ccc(C(=O)O)cc4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234870 116784 0 None -12 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 571 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc(-c4ccc(C(=O)O)cc4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
118103698 170451 0 None -12 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 724 15 5 10 2.5 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4204655 170451 0 None -12 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 724 15 5 10 2.5 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
71660821 170507 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 4 4.9 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4205214 170507 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 4 4.9 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093557 171438 0 None -3 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 477 5 1 5 4.4 O=C([C@@H]1CSCN1Cc1cc(Cl)c(CO)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4216682 171438 0 None -3 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 477 5 1 5 4.4 O=C([C@@H]1CSCN1Cc1cc(Cl)c(CO)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
71660821 170507 0 None -1 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 4 4.9 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4205214 170507 0 None -1 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 4 4.9 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
145972818 171421 0 None 3 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 734 13 6 12 1.3 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccn(Cc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)n1 10.1021/acs.jmedchem.8b00308
CHEMBL4216361 171421 0 None 3 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 734 13 6 12 1.3 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccn(Cc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)n1 10.1021/acs.jmedchem.8b00308
164617636 192129 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 530 5 1 4 7.4 COCC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4860100 192129 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 530 5 1 4 7.4 COCC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
44457471 104819 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 394 4 2 2 5.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3F 10.1021/jm7015864
CHEMBL273087 104819 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 394 4 2 2 5.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3F 10.1021/jm7015864
5059 213140 44 None -2 3 Human 5.6 pEC50 = 5.6 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 335 8 1 3 5.4 CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL8747 213140 44 None -2 3 Human 5.6 pEC50 = 5.6 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 335 8 1 3 5.4 CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
10873253 83970 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 C[C@H](CCC(=O)O)[C@H]1[C@@H](O)C[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/ml200256d
CHEMBL2062552 83970 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 C[C@H](CCC(=O)O)[C@H]1[C@@H](O)C[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/ml200256d
CHEMBL2079119 83970 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 408 4 4 4 3.4 C[C@H](CCC(=O)O)[C@H]1[C@@H](O)C[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/ml200256d
118735268 125612 0 None -2 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1398 41 2 18 10.9 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421904 125612 0 None -2 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1398 41 2 18 10.9 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
45483949 10354 35 None 2 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2020.112619
7048 10354 35 None 2 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2020.112619
CHEMBL567640 10354 35 None 2 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2020.112619
118104397 170952 0 None -15 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 750 14 6 12 2.2 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)o1 10.1021/acs.jmedchem.8b00308
CHEMBL4210547 170952 0 None -15 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 750 14 6 12 2.2 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)o1 10.1021/acs.jmedchem.8b00308
118093510 170965 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 475 4 0 4 5.7 CC1(C)SC[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4210686 170965 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 475 4 0 4 5.7 CC1(C)SC[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
71660823 171159 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 0 4 4.2 O=C([C@@H]1COCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4213036 171159 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 0 4 4.2 O=C([C@@H]1COCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118104381 171314 0 None -7 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1cccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)c1 10.1021/acs.jmedchem.8b00308
CHEMBL4215045 171314 0 None -7 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1cccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)c1 10.1021/acs.jmedchem.8b00308
46233055 207502 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1cc(Cl)ccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C 10.1016/j.bmcl.2010.01.003
CHEMBL600021 207502 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1cc(Cl)ccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C 10.1016/j.bmcl.2010.01.003
118093402 170999 0 None -1 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4211041 170999 0 None -1 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118464662 165918 0 None -22 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 687 16 0 8 7.3 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4097990 165918 0 None -22 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 687 16 0 8 7.3 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
71661223 171212 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4213705 171212 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 429 4 0 3 5.0 O=C([C@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232983 207667 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccccc1F 10.1016/j.bmcl.2010.01.003
CHEMBL601448 207667 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccccc1F 10.1016/j.bmcl.2010.01.003
46233053 207904 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C 10.1016/j.bmcl.2010.01.003
CHEMBL603107 207904 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C 10.1016/j.bmcl.2010.01.003
46232359 208155 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.9 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2010.01.003
CHEMBL604520 208155 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.9 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2010.01.003
118093511 170804 0 None 3 2 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 388 3 0 2 4.9 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4208655 170804 0 None 3 2 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 388 3 0 2 4.9 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.8b00308
118586278 166513 0 None -50 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccccc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4104779 166513 0 None -50 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccccc2)cc1OC 10.1021/acs.jmedchem.6b01873
137630592 167877 0 None - 1 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 599 13 0 6 7.4 COc1ccc(N(C)c2c(CCCC[N+](C)(C)C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4068186 167877 0 None - 1 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 599 13 0 6 7.4 COc1ccc(N(C)c2c(CCCC[N+](C)(C)C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116953 167877 0 None - 1 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 599 13 0 6 7.4 COc1ccc(N(C)c2c(CCCC[N+](C)(C)C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
44427764 100052 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 4 3 3 4.7 C[C@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O)C(=O)O 10.1021/jm070633p
CHEMBL245001 100052 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 4 3 3 4.7 C[C@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O)C(=O)O 10.1021/jm070633p
71541720 94061 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 353 6 2 5 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccccc1)CC2 10.1021/ml300277t
CHEMBL2331643 94061 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 353 6 2 5 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccccc1)CC2 10.1021/ml300277t
156705111 189709 0 None 2 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 455 5 1 6 4.9 O=C(O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4792593 189709 0 None 2 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 455 5 1 6 4.9 O=C(O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
90654593 116745 0 None -2 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 530 7 2 7 3.2 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(C(=O)O)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
CHEMBL3234580 116745 0 None -2 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 530 7 2 7 3.2 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCC(C(=O)O)CC4)nc(C(F)(F)F)n3)C2)cc1 10.1021/jm401731q
71455632 89763 0 None -2 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 401 5 0 5 4.5 COc1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
CHEMBL2181223 89763 0 None -2 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 401 5 0 5 4.5 COc1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
164620346 192993 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 555 4 2 3 8.5 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4873169 192993 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 555 4 2 3 8.5 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
164626982 193085 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 5 2 3 8.3 CCCNC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4874555 193085 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 5 2 3 8.3 CCCNC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
164627955 193179 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 516 4 2 4 6.7 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)CO)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4875868 193179 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 516 4 2 4 6.7 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)CO)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
73350994 99503 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1cccs1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435942 99503 0 None 1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1cccs1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
118577298 167765 0 None -18 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4086463 167765 0 None -18 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4096633 167765 0 None -18 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116110 167765 0 None -18 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
137656785 166465 0 None - 1 Mouse 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 510 5 0 5 7.3 Fc1ccc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc4c(c2)OCO4)CCC3)cc1 10.1021/acsmedchemlett.7b00116
CHEMBL4104148 166465 0 None - 1 Mouse 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 510 5 0 5 7.3 Fc1ccc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc4c(c2)OCO4)CCC3)cc1 10.1021/acsmedchemlett.7b00116
164623929 193020 0 None -31 2 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at N-terminal HA-tagged mouse TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged mouse TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 528 5 1 3 8.5 CCCC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4873587 193020 0 None -31 2 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at N-terminal HA-tagged mouse TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged mouse TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 528 5 1 3 8.5 CCCC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
247732 102924 25 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@H](O)CC[C@]34C)[C@@H]1CCC2=O 10.1021/jm7015864
CHEMBL260526 102924 25 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@H](O)CC[C@]34C)[C@@H]1CCC2=O 10.1021/jm7015864
44457504 104312 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 388 5 1 1 7.2 CC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL270494 104312 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 388 5 1 1 7.2 CC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
1452577 116714 1 None -4 2 Mouse 4.6 pEC50 = 4.6 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccccc3)C2)n1 10.1021/jm401731q
CHEMBL3234550 116714 1 None -4 2 Mouse 4.6 pEC50 = 4.6 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccccc3)C2)n1 10.1021/jm401731q
137657436 166356 0 None - 1 Mouse 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4ccc(F)cc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4102817 166356 0 None - 1 Mouse 4.6 pEC50 = 4.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4ccc(F)cc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
156017547 184566 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 359 2 2 3 4.5 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
CHEMBL4643260 184566 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 359 2 2 3 4.5 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
71459273 89761 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181221 89761 0 None 1 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
5283906 166905 36 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 374 4 1 2 5.7 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL410893 166905 36 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 374 4 1 2 5.7 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
164626661 193373 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 614 6 3 5 7.5 CC(C)[C@@H]1CC[C@]2(NC(=O)OCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4878597 193373 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 614 6 3 5 7.5 CC(C)[C@@H]1CC[C@]2(NC(=O)OCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
90654565 116741 0 None -1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234576 116741 0 None -1 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
136166955 98387 0 None 3 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 359 6 1 4 4.9 Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 10.1016/j.bmcl.2013.06.017
CHEMBL2407945 98387 0 None 3 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 359 6 1 4 4.9 Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 10.1016/j.bmcl.2013.06.017
5994 11413 88 None 1 10 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 314 1 0 2 4.7 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1021/jm7015864
CHEMBL103 11413 88 None 1 10 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 314 1 0 2 4.7 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1021/jm7015864
155534680 178727 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 431 3 2 3 4.6 C[C@H](CC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL4470499 178727 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 431 3 2 3 4.6 C[C@H](CC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
118464823 165388 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 496 6 0 4 7.6 COc1cccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)c1 10.1021/acsmedchemlett.7b00116
CHEMBL4092168 165388 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 496 6 0 4 7.6 COc1cccc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)c1 10.1021/acsmedchemlett.7b00116
156011298 184165 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 401 3 2 3 5.6 CC(C)[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4638053 184165 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 401 3 2 3 5.6 CC(C)[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
71626492 118977 0 None -2 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2occc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290706 118977 0 None -2 2 Mouse 7.6 pEC50 = 7.6 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2occc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
145949879 169569 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 463 6 3 4 5.4 CCOC(=O)NCC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1[C@@H](CC)[C@H]3O 10.1021/acsmedchemlett.7b00318
CHEMBL4172216 169569 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 463 6 3 4 5.4 CCOC(=O)NCC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1[C@@H](CC)[C@H]3O 10.1021/acsmedchemlett.7b00318
1452520 116712 1 None 1 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncccn2)C1 10.1021/jm401731q
CHEMBL3234547 116712 1 None 1 2 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncccn2)C1 10.1021/jm401731q
17755103 205603 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O)C(=O)O 10.1016/j.bmc.2015.01.048
CHEMBL583611 205603 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O)C(=O)O 10.1016/j.bmc.2015.01.048
164622322 192616 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 569 4 2 3 8.8 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CCCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4867540 192616 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 569 4 2 3 8.8 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CCCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
137660218 166010 0 None 16 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 527 9 0 7 6.8 COc1ccc(SCc2cnc(SCc3c(F)cc(C#N)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4098862 166010 0 None 16 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 527 9 0 7 6.8 COc1ccc(SCc2cnc(SCc3c(F)cc(C#N)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
92810 164089 59 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 316 1 0 2 4.8 CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1021/jm7015864
CHEMBL407717 164089 59 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 316 1 0 2 4.8 CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1021/jm7015864
439763 164905 22 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL408701 164905 22 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
136166859 98384 0 None 5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407936 98384 0 None 5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
71561499 94407 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 401 4 0 6 4.2 Cc1nn(C)c(Oc2ccccc2C#N)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336217 94407 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 401 4 0 6 4.2 Cc1nn(C)c(Oc2ccccc2C#N)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
11463847 104675 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 404 3 3 3 4.3 C[C@H]([C@@H]1C[C@H]1C(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL272426 104675 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 404 3 3 3 4.3 C[C@H]([C@@H]1C[C@H]1C(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
45483949 10354 35 None -2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmcl.2014.07.026
7048 10354 35 None -2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmcl.2014.07.026
CHEMBL567640 10354 35 None -2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmcl.2014.07.026
118464802 164303 0 None - 1 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 524 5 0 5 7.3 Fc1ccc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc4c(c2)OCCO4)CCC3)cc1 10.1021/acsmedchemlett.7b00116
CHEMBL4079911 164303 0 None - 1 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 524 5 0 5 7.3 Fc1ccc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc4c(c2)OCCO4)CCC3)cc1 10.1021/acsmedchemlett.7b00116
137630926 167914 0 None -3 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 681 15 1 8 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)NCCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4086239 167914 0 None -3 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 681 15 1 8 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)NCCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4117239 167914 0 None -3 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 681 15 1 8 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)NCCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
387316 73543 48 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1016/j.ejmech.2015.09.024
CHEMBL185878 73543 48 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1016/j.ejmech.2015.09.024
118576916 164414 0 None -7 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 477 8 0 6 6.7 COc1ccc(N(C)c2cnc(SCc3c(C)cccc3C)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4081298 164414 0 None -7 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 477 8 0 6 6.7 COc1ccc(N(C)c2cnc(SCc3c(C)cccc3C)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71540077 94070 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 418 7 2 6 2.0 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)nc1)CC2 10.1021/ml300277t
CHEMBL2331652 94070 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 418 7 2 6 2.0 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)nc1)CC2 10.1021/ml300277t
90654587 116732 0 None 1 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234568 116732 0 None 1 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90654584 116729 0 None -1 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(C(F)(F)F)nc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)n2)CC1 10.1021/jm401731q
CHEMBL3234565 116729 0 None -1 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(C(F)(F)F)nc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)n2)CC1 10.1021/jm401731q
90654590 116736 0 None 1 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 502 6 1 8 2.1 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234571 116736 0 None 1 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 502 6 1 8 2.1 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
71459275 89776 0 None 7 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 427 4 0 4 5.7 CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181235 89776 0 None 7 2 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 427 4 0 4 5.7 CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
118093582 170900 0 None 12 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 710 15 6 10 2.1 O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4209927 170900 0 None 12 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 710 15 6 10 2.1 O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
53311869 89780 0 None -3 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL2181239 89780 0 None -3 2 Mouse 8.5 pEC50 = 8.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 439 4 0 4 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
71540174 94072 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 438 7 1 6 2.4 CCOc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331654 94072 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 438 7 1 6 2.4 CCOc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
53311701 120339 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 414 3 0 5 4.7 CN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL3321845 120339 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 414 3 0 5 4.7 CN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
91758806 120340 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 430 3 1 6 4.4 CN1CCN(C(=O)c2cnc(O)nc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL3321846 120340 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 430 3 1 6 4.4 CN1CCN(C(=O)c2cnc(O)nc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
46232695 207693 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 386 4 0 3 5.8 CN(C(=O)c1c(-c2ccccc2Cl)noc1C1CC1)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601638 207693 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 386 4 0 3 5.8 CN(C(=O)c1c(-c2ccccc2Cl)noc1C1CC1)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232659 207905 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 4 0 3 5.5 CCc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL603112 207905 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 4 0 3 5.5 CCc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
118103702 170479 0 None - 1 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 724 15 6 10 2.2 O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)N[C@@H](C(=O)O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4204919 170479 0 None - 1 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 724 15 6 10 2.2 O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)N[C@@H](C(=O)O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
145975890 170582 0 None 19 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 16 7 10 2.3 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4206078 170582 0 None 19 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 16 7 10 2.3 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
118103734 171429 0 None 25 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
CHEMBL4216584 171429 0 None 25 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)nc1 10.1021/acs.jmedchem.8b00308
118104386 171471 0 None - 1 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 15 4 8 4.2 C[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](C)NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
CHEMBL4217133 171471 0 None - 1 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 15 4 8 4.2 C[C@@H](NC(=O)[C@@H](C)NC(=O)[C@@H](C)NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
145967535 171572 0 None 15 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 15 6 10 2.3 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4218315 171572 0 None 15 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 15 6 10 2.3 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
90644447 119008 0 None 2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 10 1 8 5.8 CCOC(=O)CNC(=O)CCc1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290737 119008 0 None 2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 10 1 8 5.8 CCOC(=O)CNC(=O)CCc1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
71455636 89792 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 442 5 0 5 5.5 CCCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181253 89792 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 442 5 0 5 5.5 CCCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
71452079 89794 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 440 5 0 5 5.2 C=CCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181255 89794 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 440 5 0 5 5.2 C=CCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
90654596 116748 0 None -15 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 10 2 8 4.0 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(CC(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234583 116748 0 None -15 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 608 10 2 8 4.0 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(N3CCC(Oc4ccc(CC(=O)O)cc4)CC3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
71459273 89761 0 None -1 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181221 89761 0 None -1 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
71452080 89795 0 None -10 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 440 4 0 5 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181256 89795 0 None -10 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 440 4 0 5 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
164617886 191636 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 501 3 2 3 7.3 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(N)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4852436 191636 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 501 3 2 3 7.3 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(N)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
118464664 163969 0 None 2 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 478 6 0 6 5.9 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4075703 163969 0 None 2 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 478 6 0 6 5.9 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
156021144 184857 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 387 3 2 3 5.3 CC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4647613 184857 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 387 3 2 3 5.3 CC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
73350994 99503 0 None -1 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1cccs1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435942 99503 0 None -1 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 520 6 0 3 7.7 O=C(c1cccs1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
14774173 196660 5 None -1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 279 4 1 3 3.5 O=C(O)c1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5169385 196660 5 None -1 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 279 4 1 3 3.5 O=C(O)c1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
101882290 121307 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
Activity at TGR5 in human NCI-H716 cells assessed as effect on intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayActivity at TGR5 in human NCI-H716 cells assessed as effect on intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 446 6 3 4 5.2 COc1ccc(C(=O)Nc2cccc(C(=O)O)c2)c(NC(=O)c2ccc(C(C)(C)C)cc2)c1 10.1021/jm500937v
CHEMBL3335672 121307 0 None - 1 Human 4.5 pEC50 = 4.5 Functional
Activity at TGR5 in human NCI-H716 cells assessed as effect on intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayActivity at TGR5 in human NCI-H716 cells assessed as effect on intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 446 6 3 4 5.2 COc1ccc(C(=O)Nc2cccc(C(=O)O)c2)c(NC(=O)c2ccc(C(C)(C)C)cc2)c1 10.1021/jm500937v
9848818 104676 53 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL272427 104676 53 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
118735266 125610 0 None -2 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1178 26 2 13 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421902 125610 0 None -2 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 1178 26 2 13 10.8 O=C(CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NCCOCCOCCOCCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
10133 7697 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2011.03.004
145714624 7697 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2011.03.004
4361 7697 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2011.03.004
608 7697 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2011.03.004
CHEMBL240597 7697 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2011.03.004
DB06777 7697 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2011.03.004
89707030 178547 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 391 4 3 3 3.9 C[C@H](CCC(N)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL4467588 178547 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 391 4 3 3 3.9 C[C@H](CCC(N)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
118464758 163175 0 None -95 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 560 7 0 5 8.2 COc1cc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc(Cl)c(OC)c2)CCC3)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4066466 163175 0 None -95 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 560 7 0 5 8.2 COc1cc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc(Cl)c(OC)c2)CCC3)ccc1F 10.1021/acsmedchemlett.7b00116
164618147 192144 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 599 6 2 5 7.6 CC(C)[C@@H]1CC[C@]2(C(=O)OCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4860380 192144 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 599 6 2 5 7.6 CC(C)[C@@H]1CC[C@]2(C(=O)OCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
130361936 176637 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 430 5 2 5 4.4 CO[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCc4nn[nH]n4)[C@@H]3[C@H](O)C[C@@H]2C1 10.1021/acs.jmedchem.9b00770
CHEMBL4440213 176637 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 430 5 2 5 4.4 CO[C@@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@H]4[C@H](C)CCc4nn[nH]n4)[C@@H]3[C@H](O)C[C@@H]2C1 10.1021/acs.jmedchem.9b00770
73353940 99494 0 None 27 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 582 6 0 4 7.0 O=C(c1ccccc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435932 99494 0 None 27 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 582 6 0 4 7.0 O=C(c1ccccc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
71459274 89762 0 None -3 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1cccc(Cl)c1)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181222 89762 0 None -3 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1cccc(Cl)c1)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
71450252 89781 0 None -10 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.2 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181240 89781 0 None -10 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 453 4 0 4 6.2 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCN(C2CCC2)c2ccccc21 10.1021/jm301071h
90654563 116739 0 None -1 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.8 CN1CCN(c2cc(N3CCCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234574 116739 0 None -1 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 501 6 1 7 2.8 CN1CCN(c2cc(N3CCCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
118093535 171225 0 None -5 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 10 1.4 O=C(CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4213844 171225 0 None -5 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 10 1.4 O=C(CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
118103672 171229 0 None -31 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 679 14 5 8 3.6 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4213913 171229 0 None -31 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 679 14 5 8 3.6 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC(CO)(CO)CO 10.1021/acs.jmedchem.8b00308
145974037 171533 0 None -15 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 725 15 7 10 1.9 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4217797 171533 0 None -15 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 725 15 7 10 1.9 O=C(NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
44605616 205074 67 None 28 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/jm901434t
CHEMBL575966 205074 67 None 28 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/jm901434t
44605616 205074 67 None 28 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL575966 205074 67 None 28 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232628 207596 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 4 0 3 5.6 CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL600833 207596 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 4 0 3 5.6 CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232595 208162 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2ccccc2C(F)(F)F)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL604543 208162 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2ccccc2C(F)(F)F)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
118103700 170762 0 None 3 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 764 14 6 13 1.4 Cn1nc(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cc1OCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4208057 170762 0 None 3 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 764 14 6 13 1.4 Cn1nc(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cc1OCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118103673 170809 1 None 12 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 597 8 1 6 6.2 O=C(O)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4208726 170809 1 None 12 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 597 8 1 6 6.2 O=C(O)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
118104381 171314 0 None 7 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1cccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)c1 10.1021/acs.jmedchem.8b00308
CHEMBL4215045 171314 0 None 7 2 Mouse 7.5 pEC50 = 7.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 760 14 6 11 2.6 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1cccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)c1 10.1021/acs.jmedchem.8b00308
137636348 162644 0 None -12 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 524 7 0 5 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4060315 162644 0 None -12 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 524 7 0 5 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
73353943 99506 0 None 3 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 518 6 0 3 7.8 CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 10.1016/j.ejmech.2013.07.050
CHEMBL2435945 99506 0 None 3 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 518 6 0 3 7.8 CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1cnccc1-c1ccccc1)C(=O)c1ccco1 10.1016/j.ejmech.2013.07.050
64980 212246 8 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 458 2 2 3 6.1 CC(=O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL80460 212246 8 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 458 2 2 3 6.1 CC(=O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
118464758 163175 0 None 95 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 560 7 0 5 8.2 COc1cc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc(Cl)c(OC)c2)CCC3)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4066466 163175 0 None 95 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 560 7 0 5 8.2 COc1cc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc(Cl)c(OC)c2)CCC3)ccc1F 10.1021/acsmedchemlett.7b00116
71561617 94413 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1ccncc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336225 94413 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1ccncc1 10.1016/j.bmcl.2012.12.076
71453902 89784 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 373 4 0 4 4.9 CN(C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl)c1ccccc1 10.1021/jm301071h
CHEMBL2181243 89784 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 373 4 0 4 4.9 CN(C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl)c1ccccc1 10.1021/jm301071h
44605617 205098 1 None 5 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/ml300277t
CHEMBL576138 205098 1 None 5 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/ml300277t
118093484 170302 0 None -31 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 617 8 1 8 5.6 Cn1c(C(=O)O)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4202656 170302 0 None -31 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 617 8 1 8 5.6 Cn1c(C(=O)O)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
71660822 171544 0 None 5 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 461 4 0 4 4.9 O=C([C@@H]1CSCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4217961 171544 0 None 5 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 461 4 0 4 4.9 O=C([C@@H]1CSCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232485 207394 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 410 4 0 4 5.5 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(OC(F)(F)F)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL599347 207394 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 410 4 0 4 5.5 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(OC(F)(F)F)cc1 10.1016/j.bmcl.2010.01.003
46232596 207844 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2cccc(C(F)(F)F)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL602691 207844 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.6 Cc1onc(-c2cccc(C(F)(F)F)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232486 208316 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 351 3 0 4 4.5 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C#N)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL605356 208316 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 351 3 0 4 4.5 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C#N)cc1 10.1016/j.bmcl.2010.01.003
46232656 208880 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 5 0 3 6.0 CCCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL608867 208880 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 5 0 3 6.0 CCCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
71660823 171159 0 None -1 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 0 4 4.2 O=C([C@@H]1COCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4213036 171159 0 None -1 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 0 4 4.2 O=C([C@@H]1COCCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093420 171324 0 None -1 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
CHEMBL4215113 171324 0 None -1 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 459 5 0 4 4.6 CO[C@H]1C[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N(Cc2cc(Cl)ccc2Cl)C1 10.1021/acs.jmedchem.8b00308
5283820 104734 65 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL272621 104734 65 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
46232657 207598 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 386 4 0 3 5.8 Cc1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C1CC1 10.1016/j.bmcl.2010.01.003
CHEMBL600835 207598 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 386 4 0 3 5.8 Cc1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C1CC1 10.1016/j.bmcl.2010.01.003
46232698 207629 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 372 2 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N1CCc2cc(Cl)ccc21 10.1016/j.bmcl.2010.01.003
CHEMBL601218 207629 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 372 2 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N1CCc2cc(Cl)ccc21 10.1016/j.bmcl.2010.01.003
723048 207703 20 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 346 3 1 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)Nc1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601671 207703 20 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 346 3 1 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)Nc1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
44626599 204509 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 573 4 1 4 8.9 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\OC(=O)c6ccccc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL571478 204509 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 573 4 1 4 8.9 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\OC(=O)c6ccccc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
71561367 94402 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 412 4 0 5 4.6 Cc1nn(C)c(Oc2cccc(F)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336212 94402 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 412 4 0 5 4.6 Cc1nn(C)c(Oc2cccc(F)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
73353941 99495 0 None 28 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 572 6 0 5 6.6 O=C(c1ccco1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435933 99495 0 None 28 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 572 6 0 5 6.6 O=C(c1ccco1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
73357026 99502 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 504 6 0 3 7.2 O=C(c1ccoc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435941 99502 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 504 6 0 3 7.2 O=C(c1ccoc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
90654570 116715 0 None 2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 342 5 1 4 2.5 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(F)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234551 116715 0 None 2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 342 5 1 4 2.5 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(F)cc3)C2)n1 10.1021/jm401731q
441302 104637 67 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@H](O)CC[C@@]43C)[C@@H]1CCC2=O 10.1021/jm7015864
CHEMBL272195 104637 67 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@H](O)CC[C@@]43C)[C@@H]1CCC2=O 10.1021/jm7015864
118464804 163322 0 None 4 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 568 9 1 6 6.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(CCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4068168 163322 0 None 4 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 568 9 1 6 6.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(CCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
24969872 24441 0 None 10 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1021/ml300277t
CHEMBL1258423 24441 0 None 10 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1021/ml300277t
126700765 163284 0 None -8 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 9 0 6 6.2 COc1ccc(CN(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4067717 163284 0 None -8 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 9 0 6 6.2 COc1ccc(CN(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
90654571 116716 0 None 2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 402 5 1 4 3.1 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Br)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234552 116716 0 None 2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 402 5 1 4 3.1 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Br)cc3)C2)n1 10.1021/jm401731q
71561754 94419 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 432 6 0 5 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C(C)C 10.1016/j.bmcl.2012.12.076
CHEMBL2336232 94419 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 432 6 0 5 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C(C)C 10.1016/j.bmcl.2012.12.076
155339374 188645 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 569 11 7 8 1.6 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1039/d0md00425a
CHEMBL4778769 188645 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 569 11 7 8 1.6 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1039/d0md00425a
118464724 166244 0 None 61 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 528 7 0 6 6.8 COc1ccc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4101442 166244 0 None 61 2 Mouse 6.5 pEC50 = 6.5 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 528 7 0 6 6.8 COc1ccc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
439763 164905 22 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation in presence of 3-isobutyl-1-methylxanthine after 20 minsAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation in presence of 3-isobutyl-1-methylxanthine after 20 mins
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acs.jmedchem.9b00770
CHEMBL408701 164905 22 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation in presence of 3-isobutyl-1-methylxanthine after 20 minsAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation in presence of 3-isobutyl-1-methylxanthine after 20 mins
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acs.jmedchem.9b00770
71626834 125608 0 None 2 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 10 2 6 5.3 O=C(O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421900 125608 0 None 2 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 10 2 6 5.3 O=C(O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
10133 7697 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
145714624 7697 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
4361 7697 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
608 7697 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
CHEMBL240597 7697 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
DB06777 7697 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.9b00770
10133 7697 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.6b01126
145714624 7697 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.6b01126
4361 7697 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.6b01126
608 7697 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.6b01126
CHEMBL240597 7697 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.6b01126
DB06777 7697 78 None -1 4 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/acs.jmedchem.6b01126
44627310 205559 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 474 3 3 3 6.1 CC(CO)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL583203 205559 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 474 3 3 3 6.1 CC(CO)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
5881 213629 78 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 288 0 1 2 3.9 C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CCC2=O 10.1021/jm7015864
CHEMBL90593 213629 78 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 288 0 1 2 3.9 C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CCC2=O 10.1021/jm7015864
71559936 94398 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 394 4 0 5 4.4 Cc1nn(C)c(Oc2ccccc2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336208 94398 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 394 4 0 5 4.4 Cc1nn(C)c(Oc2ccccc2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
126673445 164327 0 None -47 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 8 0 6 6.7 COc1ccc(N(C)c2c(C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4080290 164327 0 None -47 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 8 0 6 6.7 COc1ccc(N(C)c2c(C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
155669594 189913 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 394 4 0 4 3.8 O=C(c1cncn1Cc1ccc(F)cc1F)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4795121 189913 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 394 4 0 4 3.8 O=C(c1cncn1Cc1ccc(F)cc1F)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
12310288 165505 43 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL409348 165505 43 None - 1 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
90644457 119005 0 None -2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 8 2 8 4.9 Cc1c(/C=C/C(=O)NCC(=O)O)oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
CHEMBL3290734 119005 0 None -2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 8 2 8 4.9 Cc1c(/C=C/C(=O)NCC(=O)O)oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
118464680 165439 0 None -46 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 526 7 0 5 7.6 COc1ccc([C@@H]2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4092785 165439 0 None -46 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 526 7 0 5 7.6 COc1ccc([C@@H]2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
45483949 10354 35 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/jm901390p
7048 10354 35 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/jm901390p
CHEMBL567640 10354 35 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/jm901390p
156705120 188652 0 None -41 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 503 6 0 7 5.6 O=C(OCCl)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4778884 188652 0 None -41 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 503 6 0 7 5.6 O=C(OCCl)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
71559937 94399 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 410 4 0 5 4.9 Cc1nn(C)c(Oc2cccc(Cl)c2)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336209 94399 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 410 4 0 5 4.9 Cc1nn(C)c(Oc2cccc(Cl)c2)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
73352466 99486 0 None 4 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 453 5 1 3 6.3 N#CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435924 99486 0 None 4 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 453 5 1 3 6.3 N#CC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
90644448 119007 0 None 2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 1 6 6.2 Cc1c(CCC(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
CHEMBL3290736 119007 0 None 2 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 1 6 6.2 Cc1c(CCC(=O)O)oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c12 10.1016/j.ejmech.2014.05.031
118576935 164729 0 None -43 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 485 8 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4084668 164729 0 None -43 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 485 8 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
118576958 165184 0 None -17 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 519 8 0 6 7.0 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)c(Cl)c2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4090147 165184 0 None -17 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 519 8 0 6 7.0 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)c(Cl)c2)cc1OC 10.1021/acs.jmedchem.6b01873
89501664 168230 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 566 9 0 4 8.7 CC(C)(c1ccc(Cl)c(Cl)c1)c1cnc(SCCOCc2c(F)cccc2Cl)n1-c1ccc(F)cc1 10.1016/j.bmcl.2018.04.011
CHEMBL4127444 168230 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 566 9 0 4 8.7 CC(C)(c1ccc(Cl)c(Cl)c1)c1cnc(SCCOCc2c(F)cccc2Cl)n1-c1ccc(F)cc1 10.1016/j.bmcl.2018.04.011
73355480 99498 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 514 6 0 2 7.6 O=C(c1ccccc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435937 99498 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 514 6 0 2 7.6 O=C(c1ccccc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
1452520 116712 1 None -1 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncccn2)C1 10.1021/jm401731q
CHEMBL3234547 116712 1 None -1 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncccn2)C1 10.1021/jm401731q
118464718 165029 0 None -36 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 568 8 1 6 6.9 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)O)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4088541 165029 0 None -36 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 568 8 1 6 6.9 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)O)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
155669596 187448 0 None -1 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 358 4 0 4 3.6 O=C(c1cncn1Cc1ccccc1)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4755237 187448 0 None -1 2 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 358 4 0 4 3.6 O=C(c1cncn1Cc1ccccc1)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
71626832 125603 0 None 2 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 511 7 1 5 5.8 O=C(O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421894 125603 0 None 2 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 511 7 1 5 5.8 O=C(O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
118464622 165650 0 None -26 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 548 6 0 4 8.4 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4F)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4095058 165650 0 None -26 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 548 6 0 4 8.4 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4F)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
71561614 94406 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.3 Cc1nn(C)c(Oc2ccccc2C(F)(F)F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336216 94406 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.3 Cc1nn(C)c(Oc2ccccc2C(F)(F)F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
90654567 116743 0 None - 1 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 473 6 1 7 2.1 CN1CCN(c2cc(N3CC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234578 116743 0 None - 1 Mouse 5.5 pEC50 = 5.5 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 473 6 1 7 2.1 CN1CCN(c2cc(N3CC[C@@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
44427760 100001 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O)C(=O)O 10.1021/jm070633p
CHEMBL244783 100001 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O)C(=O)O 10.1021/jm070633p
17755103 205603 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O)C(=O)O 10.1021/jm901390p
CHEMBL583611 205603 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O)C(=O)O 10.1021/jm901390p
136166852 98409 0 None 2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2408107 98409 0 None 2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
44457475 102970 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 509 9 2 3 6.5 CCC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL260737 102970 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 509 9 2 3 6.5 CCC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@H]12 10.1021/jm7015864
45483949 10354 35 None 2 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2013.07.050
7048 10354 35 None 2 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2013.07.050
CHEMBL567640 10354 35 None 2 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.ejmech.2013.07.050
31401 54883 80 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL1551 54883 80 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
45485277 204512 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 553 4 1 4 8.7 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@](C)(CC[C@@H]4[C@@]5(C)CC/C(=N\OC(=O)C(C)C)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL571493 204512 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 553 4 1 4 8.7 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@](C)(CC[C@@H]4[C@@]5(C)CC/C(=N\OC(=O)C(C)C)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
118586279 162631 0 None 2 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 535 8 0 6 7.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(C(F)(F)F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4060122 162631 0 None 2 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 535 8 0 6 7.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(C(F)(F)F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
114611 104448 43 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL271208 104448 43 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
137653533 165542 0 None -48 2 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 702 16 5 9 5.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NC(CCCNC(=N)N)C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4094009 165542 0 None -48 2 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 702 16 5 9 5.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NC(CCCNC(=N)N)C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
155669593 190001 0 None -31 2 Mouse 5.4 pEC50 = 5.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 392 4 0 4 4.2 O=C(c1cncn1Cc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4796107 190001 0 None -31 2 Mouse 5.4 pEC50 = 5.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 392 4 0 4 4.2 O=C(c1cncn1Cc1ccccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
164612607 192189 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 3 4 6.8 C[C@@H](O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4861151 192189 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 3 4 6.8 C[C@@H](O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
73347897 99487 0 None -6 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 435 5 1 3 6.1 N#CC(NCc1cnccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435925 99487 0 None -6 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 435 5 1 3 6.1 N#CC(NCc1cnccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
71455635 89782 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 416 5 0 5 4.9 CN(C)c1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl 10.1021/jm301071h
CHEMBL2181241 89782 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 416 5 0 5 4.9 CN(C)c1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl 10.1021/jm301071h
118464811 163569 0 None -5 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)ccc(OCCOCCOCCN(C)C)c4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4070895 163569 0 None -5 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)ccc(OCCOCCOCCN(C)C)c4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
5880 212891 40 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@H](O)CC[C@]34C)[C@@H]1CCC2=O 10.1021/jm7015864
CHEMBL85799 212891 40 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@H](O)CC[C@]34C)[C@@H]1CCC2=O 10.1021/jm7015864
71541721 94062 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 367 6 2 5 1.8 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C)cc1)CC2 10.1021/ml300277t
CHEMBL2331644 94062 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 367 6 2 5 1.8 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C)cc1)CC2 10.1021/ml300277t
90644459 118990 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 6 0 7 6.4 CCOC(=O)c1oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290719 118990 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 6 0 7 6.4 CCOC(=O)c1oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2c1C 10.1016/j.ejmech.2014.05.031
90654592 116738 0 None -2 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 517 7 1 9 1.9 CCN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4cnc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234573 116738 0 None -2 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 517 7 1 9 1.9 CCN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4cnc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90644453 118992 0 None -7 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 0 7 6.0 CCOC(=O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290721 118992 0 None -7 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 0 7 6.0 CCOC(=O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
90654574 116719 0 None -4 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 376 5 1 4 3.2 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)ncc1F 10.1021/jm401731q
CHEMBL3234555 116719 0 None -4 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 376 5 1 4 3.2 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)ncc1F 10.1021/jm401731q
137661039 166268 0 None 21 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 653 13 2 9 5.5 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4101738 166268 0 None 21 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 653 13 2 9 5.5 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
164614522 191674 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 598 6 3 4 7.2 CC(C)[C@@H]1CC[C@]2(C(=O)NCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4852971 191674 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 598 6 3 4 7.2 CC(C)[C@@H]1CC[C@]2(C(=O)NCC(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
71626765 125602 0 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 539 8 0 6 6.3 CCOC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421893 125602 0 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 539 8 0 6 6.3 CCOC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
118464620 165693 0 None - 1 Mouse 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 542 7 0 5 8.1 COc1ccc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc(Cl)c(OC)c2)CCC3)cc1 10.1021/acsmedchemlett.7b00116
CHEMBL4095497 165693 0 None - 1 Mouse 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 542 7 0 5 8.1 COc1ccc(-n2c(SCc3c(F)cccc3Cl)nc3c2C(c2ccc(Cl)c(OC)c2)CCC3)cc1 10.1021/acsmedchemlett.7b00116
71561370 94405 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 424 4 0 5 5.2 Cc1ccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c(Cl)c1 10.1016/j.bmcl.2012.12.076
CHEMBL2336215 94405 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 424 4 0 5 5.2 Cc1ccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c(Cl)c1 10.1016/j.bmcl.2012.12.076
73349425 99485 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 456 6 1 2 7.2 CCC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435922 99485 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 456 6 1 2 7.2 CCC(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
1012 6814 86 None -22387 4 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm7015864
1013 6814 86 None -22387 4 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm7015864
1057 6814 86 None -22387 4 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm7015864
5757 6814 86 None -22387 4 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm7015864
CHEMBL135 6814 86 None -22387 4 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm7015864
DB00783 6814 86 None -22387 4 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 272 0 2 2 3.6 Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2O)C 10.1021/jm7015864
71453905 89789 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 3 0 4 5.2 O=C(c1ncncc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
CHEMBL2181250 89789 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 3 0 4 5.2 O=C(c1ncncc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
162665892 189104 0 None -16 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 537 6 0 7 6.0 O=C(OCC(F)(F)F)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4784355 189104 0 None -16 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 537 6 0 7 6.0 O=C(OCC(F)(F)F)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
12544 54952 32 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL1552 54952 32 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 449 6 4 4 3.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
77845059 118991 0 None -22 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 517 6 0 7 6.1 CCOC(=O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290720 118991 0 None -22 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 517 6 0 7 6.1 CCOC(=O)c1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
118093582 170900 0 None -12 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 710 15 6 10 2.1 O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4209927 170900 0 None -12 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 710 15 6 10 2.1 O=C(CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
145971348 171349 0 None 1 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 481 4 0 4 5.2 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1C(F)(F)F)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4215354 171349 0 None 1 2 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 481 4 0 4 5.2 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1C(F)(F)F)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232629 207597 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 4 0 3 6.0 Cc1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C(C)C 10.1016/j.bmcl.2010.01.003
CHEMBL600834 207597 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 388 4 0 3 6.0 Cc1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C(C)C 10.1016/j.bmcl.2010.01.003
118103669 170976 0 None - 1 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 1047 28 13 18 -2.1 O=C(NCCCN(CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4210783 170976 0 None - 1 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 1047 28 13 18 -2.1 O=C(NCCCN(CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCOc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
74766512 164226 0 None -3 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 699 17 0 9 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4079040 164226 0 None -3 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 699 17 0 9 7.2 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
71561619 94415 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 430 4 0 5 5.2 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336227 94415 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 430 4 0 5 5.2 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
71541719 94064 1 None -194 3 Rat 5.4 pEC50 = 5.4 Functional
Agonist activity at rat TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at rat TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
CHEMBL2331646 94064 1 None -194 3 Rat 5.4 pEC50 = 5.4 Functional
Agonist activity at rat TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at rat TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
118464639 164940 0 None - 1 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 541 7 0 6 7.5 COc1cc(C2CCCc3nc(SCc4c(F)cccc4[N+](=O)[O-])n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4087370 164940 0 None - 1 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 541 7 0 6 7.5 COc1cc(C2CCCc3nc(SCc4c(F)cccc4[N+](=O)[O-])n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
118103673 170809 1 None -12 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 597 8 1 6 6.2 O=C(O)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
CHEMBL4208726 170809 1 None -12 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 597 8 1 6 6.2 O=C(O)c1ccc(COc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cc1 10.1021/acs.jmedchem.8b00308
118103718 171300 0 None 1 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 9 1.4 O=C(CCc1cc(Cl)c(CN2C[C@@H](F)C[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4214838 171300 0 None 1 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 9 1.4 O=C(CCc1cc(Cl)c(CN2C[C@@H](F)C[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
46232982 208201 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL604751 208201 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
46233023 208428 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C 10.1016/j.bmcl.2010.01.003
CHEMBL605986 208428 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1ccccc1N(C)C(=O)c1c(-c2ccccc2Cl)noc1C 10.1016/j.bmcl.2010.01.003
118093493 170351 0 None -3 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 664 13 6 9 1.5 O=C(CCc1cc(Cl)c(CN2CCC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4203191 170351 0 None -3 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 664 13 6 9 1.5 O=C(CCc1cc(Cl)c(CN2CCC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
118093510 170965 0 None -1 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 475 4 0 4 5.7 CC1(C)SC[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4210686 170965 0 None -1 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 475 4 0 4 5.7 CC1(C)SC[C@@H](C(=O)N2CCN(C3CC3)c3ccccc32)N1Cc1cc(Cl)ccc1Cl 10.1021/acs.jmedchem.8b00308
118093506 171501 0 None 1 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4217450 171501 0 None 1 2 Mouse 6.4 pEC50 = 6.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
5283932 104442 23 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 390 4 2 3 4.7 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CCC(=O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL271172 104442 23 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 390 4 2 3 4.7 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CCC(=O)C[C@H]1C[C@H]3O 10.1021/jm7015864
71660856 170985 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 406 3 0 3 5.1 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4210879 170985 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 406 3 0 3 5.1 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 10.1021/acs.jmedchem.8b00308
46232487 207188 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 369 4 0 4 4.6 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL598120 207188 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 369 4 0 4 4.6 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2010.01.003
749179 209323 17 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 326 3 0 3 4.6 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccccc1 10.1016/j.bmcl.2010.01.003
CHEMBL611676 209323 17 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 326 3 0 3 4.6 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccccc1 10.1016/j.bmcl.2010.01.003
90654585 116730 0 None 2 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 465 6 1 7 2.1 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)nc(N2CCN(C)CC2)c1F 10.1021/jm401731q
CHEMBL3234566 116730 0 None 2 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 465 6 1 7 2.1 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)nc(N2CCN(C)CC2)c1F 10.1021/jm401731q
90654566 116742 0 None -1 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 473 6 1 7 2.1 CN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234577 116742 0 None -1 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 473 6 1 7 2.1 CN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90654564 116740 0 None 1 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234575 116740 0 None 1 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90654568 116744 0 None 4 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 7 1 8 1.8 CCN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)nc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234579 116744 0 None 4 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 7 1 8 1.8 CCN1CCN(c2cc(N3CC[C@H]3C(=O)NCCc3ccc(C#N)nc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
90654594 116746 0 None 3 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 544 7 2 7 3.6 CC1(C(=O)O)CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234581 116746 0 None 3 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 544 7 2 7 3.6 CC1(C(=O)O)CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
118576999 166484 0 None 17 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 566 9 0 7 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CCN(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4104359 166484 0 None 17 2 Mouse 8.4 pEC50 = 8.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 566 9 0 7 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CCN(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
162657867 187808 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 390 5 0 5 3.5 COc1ccc(N2CCN(C(=O)c3cncn3[C@H](C)c3ccccc3)CC2)cc1 10.1016/j.bmc.2020.115972
CHEMBL4759282 187808 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 390 5 0 5 3.5 COc1ccc(N2CCN(C(=O)c3cncn3[C@H](C)c3ccccc3)CC2)cc1 10.1016/j.bmc.2020.115972
156705119 189893 0 None 29 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 499 7 0 8 5.0 COCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4794753 189893 0 None 29 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 499 7 0 8 5.0 COCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
71540075 94068 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 435 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331650 94068 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 435 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC(F)(F)F)cc1)CC2 10.1021/ml300277t
118586284 163326 0 None 9 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 503 8 0 6 6.5 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2F)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4068227 163326 0 None 9 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 503 8 0 6 6.5 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2F)cc1OC 10.1021/acs.jmedchem.6b01873
71626557 118973 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1cccc2ncccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290702 118973 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1cccc2ncccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
126700765 163284 0 None 8 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 9 0 6 6.2 COc1ccc(CN(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4067717 163284 0 None 8 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 9 0 6 6.2 COc1ccc(CN(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
101886309 121689 26 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assayAgonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.6 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCO)[C@@H]2[C@@H]1O 10.1021/jm501273r
CHEMBL3342086 121689 26 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assayAgonist activity at GP-BAR1 (unknown origin) in human HEK293 cells assessed as receptor transactivation at 100 nM to 50 uM incubated for 16 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.6 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCO)[C@@H]2[C@@H]1O 10.1021/jm501273r
91668293 143159 10 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 (unknown origin) assessed as cAMP levelAgonist activity at TGR5 (unknown origin) assessed as cAMP level
ChEMBL 576 9 4 3 7.1 C[C@H](CCC(=O)N[C@H](CC(=O)O)Cc1c[nH]c2ccccc12)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.ejmech.2015.08.048
CHEMBL3735125 143159 10 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 (unknown origin) assessed as cAMP levelAgonist activity at TGR5 (unknown origin) assessed as cAMP level
ChEMBL 576 9 4 3 7.1 C[C@H](CCC(=O)N[C@H](CC(=O)O)Cc1c[nH]c2ccccc12)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.ejmech.2015.08.048
73353938 99481 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 512 5 1 3 6.1 O=S(=O)(NCc1c(-c2ccccc2F)ccnc1Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435915 99481 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 512 5 1 3 6.1 O=S(=O)(NCc1c(-c2ccccc2F)ccnc1Cl)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
73353942 99500 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 515 6 0 3 7.0 O=C(c1ccncc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435939 99500 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 515 6 0 3 7.0 O=C(c1ccncc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
118709773 120338 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 446 4 1 6 5.4 CSc1ncc(C(=O)N2CCNc3ccccc32)c(Oc2cc(Cl)ccc2Cl)n1 10.1016/j.bmcl.2014.07.026
CHEMBL3321844 120338 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 446 4 1 6 5.4 CSc1ncc(C(=O)N2CCNc3ccccc32)c(Oc2cc(Cl)ccc2Cl)n1 10.1016/j.bmcl.2014.07.026
71626490 118972 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 421 4 0 4 5.7 O=C(c1cnccc1Oc1ccc2ccccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290701 118972 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 421 4 0 4 5.7 O=C(c1cnccc1Oc1ccc2ccccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
118576916 164414 0 None 7 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 477 8 0 6 6.7 COc1ccc(N(C)c2cnc(SCc3c(C)cccc3C)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4081298 164414 0 None 7 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 477 8 0 6 6.7 COc1ccc(N(C)c2cnc(SCc3c(C)cccc3C)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
162656549 187733 0 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@@H]2[C@H]([C@@H]3CC[C@H]([C@H](C)CCC(=O)O)[C@@]3(C)C[C@H]2O)[C@@H]1O 10.1021/acs.jmedchem.6b01126
CHEMBL4758363 187733 0 None - 1 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@@H]2[C@H]([C@@H]3CC[C@H]([C@H](C)CCC(=O)O)[C@@]3(C)C[C@H]2O)[C@@H]1O 10.1021/acs.jmedchem.6b01126
44627314 204525 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 510 4 2 2 8.4 C=C(C)C[C@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
CHEMBL571592 204525 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 510 4 2 2 8.4 C=C(C)C[C@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
145955411 169177 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 474 6 4 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)NC3CC3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4165830 169177 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 474 6 4 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)NC3CC3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
137651232 164147 0 None -20 2 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 570 10 1 9 6.1 COc1ccc(SCc2cnc(SCc3c(F)cc(-c4nn[nH]n4)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4077972 164147 0 None -20 2 Human 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 570 10 1 9 6.1 COc1ccc(SCc2cnc(SCc3c(F)cc(-c4nn[nH]n4)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
71540077 94070 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 418 7 2 6 2.0 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)nc1)CC2 10.1021/ml300277t
CHEMBL2331652 94070 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 418 7 2 6 2.0 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)(F)F)nc1)CC2 10.1021/ml300277t
71540175 94073 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 434 6 1 5 2.9 NC(=O)c1nc(C2CC2)nc2c1CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331655 94073 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 434 6 1 5 2.9 NC(=O)c1nc(C2CC2)nc2c1CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71626556 118978 0 None -1 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2ccoc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290707 118978 0 None -1 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 411 4 0 5 5.2 O=C(c1cnccc1Oc1ccc2ccoc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
90654572 116717 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ncccn3)C2)cc1 10.1021/jm401731q
CHEMBL3234553 116717 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3ncccn3)C2)cc1 10.1021/jm401731q
118586282 166334 0 None -23 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 486 8 0 7 5.8 COc1ccc(N(C)c2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4102610 166334 0 None -23 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 486 8 0 7 5.8 COc1ccc(N(C)c2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
118464815 166295 0 None -6 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 528 6 0 4 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4102107 166295 0 None -6 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 528 6 0 4 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
44427763 103748 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 422 4 4 4 3.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O)C(=O)O 10.1021/jm070633p
CHEMBL266356 103748 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 422 4 4 4 3.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)CC1C[C@H]3O)C(=O)O 10.1021/jm070633p
11069533 104818 35 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 406 4 2 4 4.6 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL273086 104818 35 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 406 4 2 4 4.6 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
118725000 123838 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1021/jm7015864
CHEMBL3391714 123838 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1021/jm7015864
156705112 189643 0 None -15 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 483 6 0 7 5.4 CCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4791709 189643 0 None -15 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 483 6 0 7 5.4 CCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
118577011 163765 0 None 20 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 489 7 0 5 7.0 COc1cc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)ccc1Cl 10.1021/acs.jmedchem.6b01873
CHEMBL4073081 163765 0 None 20 2 Mouse 7.4 pEC50 = 7.4 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 489 7 0 5 7.0 COc1cc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)ccc1Cl 10.1021/acs.jmedchem.6b01873
91972025 162737 0 None -43 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 540 7 0 5 7.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4061329 162737 0 None -43 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 540 7 0 5 7.8 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
21121407 163414 1 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 442 5 3 4 4.3 C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL406923 163414 1 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 442 5 3 4 4.3 C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
73352462 99408 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 486 6 1 4 5.9 COC(=O)C(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435835 99408 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 486 6 1 4 5.9 COC(=O)C(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
90654586 116731 0 None -2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1nc(N2CCN(C)CC2)cc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234567 116731 0 None -2 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1nc(N2CCN(C)CC2)cc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
10635 105488 49 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
CHEMBL27769 105488 49 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@H]4CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
137661958 166303 0 None - 1 Mouse 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 562 10 1 7 5.6 COc1ccc(SCc2cnc([S+]([O-])Cc3c(F)cc(C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4102235 166303 0 None - 1 Mouse 4.4 pEC50 = 4.4 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 562 10 1 7 5.6 COc1ccc(SCc2cnc([S+]([O-])Cc3c(F)cc(C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
164620529 192471 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 551 5 2 4 6.7 CNS(=O)(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4865346 192471 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 551 5 2 4 6.7 CNS(=O)(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
71461053 89759 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 4 0 3 6.1 CN(C(=O)c1cnccc1Oc1cc(Cl)ccc1Cl)c1ccccc1Cl 10.1021/jm301071h
CHEMBL2181219 89759 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 406 4 0 3 6.1 CN(C(=O)c1cnccc1Oc1cc(Cl)ccc1Cl)c1ccccc1Cl 10.1021/jm301071h
164610027 191510 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 571 3 1 4 7.6 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)N6CCOCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4850654 191510 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 571 3 1 4 7.6 CC(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)N6CCOCC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
44605617 205098 1 None 5 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL576138 205098 1 None 5 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1016/j.bmcl.2012.12.076
73357023 99483 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 428 5 1 2 6.2 Fc1ccccc1-c1ccncc1CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435919 99483 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 428 5 1 2 6.2 Fc1ccccc1-c1ccncc1CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
156014273 183997 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 435 3 2 3 6.1 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@@](O)(c4ccccc4)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
CHEMBL4635505 183997 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 435 3 2 3 6.1 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@@](O)(c4ccccc4)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
56602333 98382 0 None 11 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407934 98382 0 None 11 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
118464806 165836 0 None 34 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4097059 165836 0 None 34 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cc(OCCOCCOCCN(C)C)cc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
73350993 99491 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 495 7 0 3 7.4 CCCN(Cc1cnccc1-c1ccccc1F)C(C#N)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435929 99491 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 495 7 0 3 7.4 CCCN(Cc1cnccc1-c1ccccc1F)C(C#N)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
71561615 94411 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@H]1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336223 94411 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@H]1c1cccnc1 10.1016/j.bmcl.2012.12.076
71452075 89760 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 371 4 0 4 4.5 O=C(c1cnccc1Oc1ccccc1)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181220 89760 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 371 4 0 4 4.5 O=C(c1cnccc1Oc1ccccc1)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
46232736 208087 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/ml300277t
CHEMBL604131 208087 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1021/ml300277t
118586284 163326 0 None -9 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 503 8 0 6 6.5 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2F)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4068227 163326 0 None -9 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 503 8 0 6 6.5 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2F)cc1OC 10.1021/acs.jmedchem.6b01873
73355481 99501 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 504 6 0 3 7.2 O=C(c1ccco1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435940 99501 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 504 6 0 3 7.2 O=C(c1ccco1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
66740913 165434 0 None -22 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 471 8 0 6 5.6 COc1ccc(Cc2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4092629 165434 0 None -22 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 471 8 0 6 5.6 COc1ccc(Cc2nnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
122844 174717 58 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 454 2 1 2 7.3 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL431525 174717 58 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 454 2 1 2 7.3 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
192254 23879 29 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 3 3 3 4.1 C[C@H](CC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL1254990 23879 29 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 378 3 3 3 4.1 C[C@H](CC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
440071 104311 10 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 563 9 3 6 4.3 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](OS(=O)(=O)O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL270493 104311 10 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 563 9 3 6 4.3 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](OS(=O)(=O)O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
9910920 203917 1 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/jm901390p
CHEMBL567835 203917 1 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/jm901390p
53311618 89790 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 399 3 0 4 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL2181251 89790 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 399 3 0 4 5.2 O=C(c1cncnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1016/j.bmcl.2014.07.026
71540074 94067 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 453 7 2 6 3.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(SC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331649 94067 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 453 7 2 6 3.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(SC(F)(F)F)cc1)CC2 10.1021/ml300277t
90654591 116737 0 None 1 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 6 2 8 1.7 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cn1 10.1021/jm401731q
CHEMBL3234572 116737 0 None 1 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 6 2 8 1.7 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cn1 10.1021/jm401731q
118464629 163034 0 None - 1 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1cc(C2CCCc3nc(SCc4c(F)cccc4OC)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4064931 163034 0 None - 1 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1cc(C2CCCc3nc(SCc4c(F)cccc4OC)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
11069533 104818 35 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 406 4 2 4 4.6 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL273086 104818 35 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 406 4 2 4 4.6 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
71457417 89758 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 401 5 0 4 5.6 CCN(C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl)c1ccccc1C 10.1021/jm301071h
CHEMBL2181218 89758 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 401 5 0 4 5.6 CCN(C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl)c1ccccc1C 10.1021/jm301071h
5283821 104733 21 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL272620 104733 21 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3C[C@@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
90654579 116724 0 None -5 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)c1 10.1021/jm401731q
CHEMBL3234560 116724 0 None -5 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)c1 10.1021/jm401731q
53311781 89774 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 398 3 0 3 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
CHEMBL2181233 89774 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 398 3 0 3 5.8 O=C(c1cnccc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
71561756 94420 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 446 6 0 5 5.6 Cc1ccc(CN(C(=O)c2c(C)nn(C)c2Oc2cccc(Cl)c2Cl)C(C)C)cn1 10.1016/j.bmcl.2012.12.076
CHEMBL2336233 94420 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 446 6 0 5 5.6 Cc1ccc(CN(C(=O)c2c(C)nn(C)c2Oc2cccc(Cl)c2Cl)C(C)C)cn1 10.1016/j.bmcl.2012.12.076
155339365 187787 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 507 11 2 5 4.8 COCCOCCNC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3OC 10.1039/d0md00425a
CHEMBL4759021 187787 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 507 11 2 5 4.8 COCCOCCNC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3OC 10.1039/d0md00425a
118464755 165284 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 544 6 0 4 8.5 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(C)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4091129 165284 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 544 6 0 4 8.5 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(C)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
71561500 94408 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 406 5 0 6 4.3 COc1cccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c1 10.1016/j.bmcl.2012.12.076
CHEMBL2336218 94408 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 406 5 0 6 4.3 COc1cccc(Oc2c(C(=O)N3CCCCC3c3cccnc3)c(C)nn2C)c1 10.1016/j.bmcl.2012.12.076
137660218 166010 0 None -16 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 527 9 0 7 6.8 COc1ccc(SCc2cnc(SCc3c(F)cc(C#N)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4098862 166010 0 None -16 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 527 9 0 7 6.8 COc1ccc(SCc2cnc(SCc3c(F)cc(C#N)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
6675 91902 40 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 515 7 5 6 2.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL224867 91902 40 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 515 7 5 6 2.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
164611776 192994 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 3 4 6.8 C[C@H](O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4873170 192994 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 543 4 3 4 6.8 C[C@H](O)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
118709777 120342 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 403 3 1 3 4.2 CN1CCN(C(=O)C2(C(=O)Nc3cc(Cl)ccc3Cl)CC2)c2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL3321850 120342 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 403 3 1 3 4.2 CN1CCN(C(=O)C2(C(=O)Nc3cc(Cl)ccc3Cl)CC2)c2ccccc21 10.1016/j.bmcl.2014.07.026
118586278 166513 0 None 50 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccccc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4104779 166513 0 None 50 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 467 8 0 6 6.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccccc2)cc1OC 10.1021/acs.jmedchem.6b01873
90644453 118992 0 None 7 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 0 7 6.0 CCOC(=O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290721 118992 0 None 7 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 531 7 0 7 6.0 CCOC(=O)Cc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71718878 94425 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1016/j.bmcl.2012.12.076
CHEMBL2336238 94425 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1016/j.bmcl.2012.12.076
71718878 94425 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1039/C2MD20174G
CHEMBL2336238 94425 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 373 5 0 6 3.3 COc1cccc(-n2nnc(C3CC3)c2C(=O)N(C)c2ccc(C#N)cc2)c1 10.1039/C2MD20174G
71626488 118984 0 None -3 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 426 4 0 6 5.0 Cc1noc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290713 118984 0 None -3 2 Mouse 8.3 pEC50 = 8.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 426 4 0 6 5.0 Cc1noc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
155339372 179849 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 444 5 1 5 5.6 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCc3nnc(C)o3)[C@@H]21 10.1021/acs.jmedchem.9b00770
CHEMBL4519596 179849 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 444 5 1 5 5.6 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCc3nnc(C)o3)[C@@H]21 10.1021/acs.jmedchem.9b00770
118464803 162563 0 None 15 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 525 7 0 6 6.6 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cncc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4059508 162563 0 None 15 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 525 7 0 6 6.6 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cncc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
71661185 170589 0 None 1 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4206153 170589 0 None 1 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093562 170666 0 None -5 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 547 9 1 5 5.7 O=C(O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4207005 170666 0 None -5 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 547 9 1 5 5.7 O=C(O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
71661185 170589 0 None -1 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4206153 170589 0 None -1 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
14650340 73958 1 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 307 7 0 3 5.0 CCCCOc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL18775 73958 1 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 307 7 0 3 5.0 CCCCOc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
136167006 98391 0 None 6 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 408 5 1 3 5.9 Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407950 98391 0 None 6 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 408 5 1 3 5.9 Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
73349428 99505 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 522 6 0 3 7.4 O=C(c1ccco1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1F 10.1016/j.ejmech.2013.07.050
CHEMBL2435944 99505 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 522 6 0 3 7.4 O=C(c1ccco1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1F 10.1016/j.ejmech.2013.07.050
12113821 204205 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 511 3 1 4 7.6 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\OC(C)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL569634 204205 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 511 3 1 4 7.6 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\OC(C)=O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
611 9107 75 None 50 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/ml200256d
9903 9107 75 None 50 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/ml200256d
CHEMBL1478 9107 75 None 50 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/ml200256d
9910920 203917 1 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acs.jmedchem.6b01126
CHEMBL567835 203917 1 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acs.jmedchem.6b01126
71626228 125606 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 10 0 7 5.8 CCOC(=O)CN(C)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421898 125606 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 10 0 7 5.8 CCOC(=O)CN(C)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
44605617 205098 1 None 5 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayAgonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/jm901434t
CHEMBL576138 205098 1 None 5 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayAgonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/jm901434t
118103736 171015 0 None 1 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 453 5 0 4 5.1 O=C([C@@H]1CSCN1Cc1cc(C2CC2)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4211208 171015 0 None 1 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 453 5 0 4 5.1 O=C([C@@H]1CSCN1Cc1cc(C2CC2)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232531 206229 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccc(F)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL591455 206229 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccc(F)cc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232985 207668 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(F)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601449 207668 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(F)cc1 10.1016/j.bmcl.2010.01.003
44605615 205551 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayAgonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 374 4 0 3 5.6 CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1cccc(Cl)c1 10.1021/jm901434t
CHEMBL583110 205551 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assayAgonist activity at TGR5 expressed in human U2-OS cells assessed as increase in MRE/CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 374 4 0 3 5.6 CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1cccc(Cl)c1 10.1021/jm901434t
44605615 205551 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 4 0 3 5.6 CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1cccc(Cl)c1 10.1016/j.bmcl.2010.01.003
CHEMBL583110 205551 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 4 0 3 5.6 CCN(C(=O)c1c(-c2ccccc2Cl)noc1C)c1cccc(Cl)c1 10.1016/j.bmcl.2010.01.003
46232594 207843 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL602690 207843 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)cc1 10.1016/j.bmcl.2010.01.003
71660856 170985 0 None -1 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 406 3 0 3 5.1 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4210879 170985 0 None -1 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 406 3 0 3 5.1 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCSc2ccccc21 10.1021/acs.jmedchem.8b00308
10479586 112973 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 442 5 3 4 4.3 C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL3138525 112973 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 442 5 3 4 4.3 C[C@H](CCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
9848818 104676 53 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.ejmech.2015.09.024
CHEMBL272427 104676 53 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/j.ejmech.2015.09.024
118586280 165066 0 None 1 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 493 6 0 4 7.7 CN(c1ccc(Cl)c(Cl)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4088938 165066 0 None 1 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 493 6 0 4 7.7 CN(c1ccc(Cl)c(Cl)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
71691935 180027 8 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 461 4 3 4 4.0 C[C@H](CCC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL4524597 180027 8 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 461 4 3 4 4.0 C[C@H](CCC(=O)N1CCCC1)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
118464701 164969 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 548 6 0 4 8.4 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(F)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4087791 164969 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 548 6 0 4 8.4 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(F)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
73357024 99488 0 None 1 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 471 5 1 3 6.4 N#CC(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435926 99488 0 None 1 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 471 5 1 3 6.4 N#CC(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
71626697 118982 0 None -3 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 427 4 0 5 5.7 O=C(c1cnccc1Oc1ccc2sccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290711 118982 0 None -3 2 Mouse 7.3 pEC50 = 7.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 427 4 0 5 5.7 O=C(c1cnccc1Oc1ccc2sccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
137645502 164437 0 None 1 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 490 7 0 7 5.8 COc1ccc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4081476 164437 0 None 1 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 490 7 0 7 5.8 COc1ccc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
145973129 169810 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 459 5 3 5 5.6 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCc3cc(O)no3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4175888 169810 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 459 5 3 5 5.6 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCc3cc(O)no3)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
90644450 119000 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 9 1 9 4.6 CCOC(=O)CNC(=O)Cc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290729 119000 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 9 1 9 4.6 CCOC(=O)CNC(=O)Cc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
73353937 99480 0 None 20 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 588 6 0 5 7.0 O=C(c1ccsc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435914 99480 0 None 20 2 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 588 6 0 5 7.0 O=C(c1ccsc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
46232736 208087 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1039/C2MD20174G
CHEMBL604131 208087 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 340 4 0 4 3.8 CCc1nnn(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1039/C2MD20174G
71626905 125604 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 596 10 1 7 5.4 CCOC(=O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421896 125604 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 596 10 1 7 5.4 CCOC(=O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
71461056 89783 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 387 4 0 4 5.2 Cc1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl 10.1021/jm301071h
CHEMBL2181242 89783 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 387 4 0 4 5.2 Cc1ccccc1N(C)C(=O)c1cncnc1Oc1cc(Cl)ccc1Cl 10.1021/jm301071h
130361940 166086 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 447 7 3 3 5.3 CCCCNC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
CHEMBL4099757 166086 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 447 7 3 3 5.3 CCCCNC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/acs.jmedchem.9b00770
115245 102592 42 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 433 6 3 3 4.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL258818 102592 42 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 433 6 3 3 4.6 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
71453904 89788 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 3 0 4 5.2 O=C(c1nccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
CHEMBL2181248 89788 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 3 0 4 5.2 O=C(c1nccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/jm301071h
71561368 94403 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2ccc(Cl)cc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336213 94403 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2ccc(Cl)cc2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
137656815 166517 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4104842 166517 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
73352467 99490 0 None -8 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 496 5 1 3 5.5 O=S(=O)(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435928 99490 0 None -8 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 496 5 1 3 5.5 O=S(=O)(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
54586161 67941 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 551 8 3 4 7.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)OC/C=C/c3ccccc3)[C@@H]2[C@@H]1O 10.1016/j.bmc.2011.03.004
CHEMBL1765565 67941 0 None - 1 Human 4.3 pEC50 = 4.3 Functional
Agonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assayAgonist activity at human TGR5 receptor expressed in NCI-H716 cells assessed as intracellular cAMP level by TR-FRET assay
ChEMBL 551 8 3 4 7.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCNC(=O)OC/C=C/c3ccccc3)[C@@H]2[C@@H]1O 10.1016/j.bmc.2011.03.004
45483949 10354 35 None -2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml300277t
7048 10354 35 None -2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml300277t
CHEMBL567640 10354 35 None -2 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml300277t
118464805 164577 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 544 6 0 4 8.4 COc1cc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4083189 164577 0 None - 1 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 544 6 0 4 8.4 COc1cc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
611 9107 75 None 50 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm900872z
9903 9107 75 None 50 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm900872z
CHEMBL1478 9107 75 None 50 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm900872z
156705115 188898 0 None -3 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 527 7 0 9 4.9 CC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4782069 188898 0 None -3 2 Mouse 6.3 pEC50 = 6.3 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 527 7 0 9 4.9 CC(=O)OCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
71541719 94064 1 None -281 3 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at mouse TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at mouse TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
CHEMBL2331646 94064 1 None -281 3 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at mouse TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at mouse TGR5 expressed in deoxycycline-induced CHO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 395 7 2 5 2.6 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C(C)C)cc1)CC2 10.1021/ml300277t
130361815 177257 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 447 8 1 5 4.2 C[C@H](CCC(N)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](OC=O)C[C@H]1C[C@H]3OC=O 10.1021/acs.jmedchem.9b00770
CHEMBL4449000 177257 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 447 8 1 5 4.2 C[C@H](CCC(N)=O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](OC=O)C[C@H]1C[C@H]3OC=O 10.1021/acs.jmedchem.9b00770
162671787 189621 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 876 23 13 15 -2.2 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N(CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1039/d0md00425a
CHEMBL4791399 189621 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 876 23 13 15 -2.2 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N(CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)CCCNC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1039/d0md00425a
155669591 189475 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 376 4 0 4 3.7 O=C(c1cncn1Cc1ccc(F)cc1)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4789395 189475 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 376 4 0 4 3.7 O=C(c1cncn1Cc1ccc(F)cc1)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
137646061 164594 0 None 3 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 502 9 0 6 6.7 COc1ccc(OCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4083324 164594 0 None 3 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 502 9 0 6 6.7 COc1ccc(OCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
137634612 162894 0 None -35 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 518 9 0 6 7.4 COc1ccc(SCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4063237 162894 0 None -35 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 518 9 0 6 7.4 COc1ccc(SCc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
156018264 184570 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 373 2 2 3 4.9 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@@](C)(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
CHEMBL4643368 184570 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 373 2 2 3 4.9 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@@](C)(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
71626905 125604 0 None -1 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 596 10 1 7 5.4 CCOC(=O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421896 125604 0 None -1 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 596 10 1 7 5.4 CCOC(=O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
71720725 94426 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 428 4 0 5 5.1 Cc1nn(C)c(Oc2cccc(Cl)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336239 94426 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 428 4 0 5 5.1 Cc1nn(C)c(Oc2cccc(Cl)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
136167037 98395 0 None -1 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407954 98395 0 None -1 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
90284086 124455 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 418 5 2 2 6.4 CC[C@H]1C[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
CHEMBL3401354 124455 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 418 5 2 2 6.4 CC[C@H]1C[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
611 9107 75 None 50 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
9903 9107 75 None 50 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
CHEMBL1478 9107 75 None 50 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/jm7015864
73352464 99482 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 410 5 1 2 6.1 FC(F)(F)c1cc(CNCc2cnccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435918 99482 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 410 5 1 2 6.1 FC(F)(F)c1cc(CNCc2cnccc2-c2ccccc2)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
1452577 116714 1 None 4 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccccc3)C2)n1 10.1021/jm401731q
CHEMBL3234550 116714 1 None 4 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 324 5 1 4 2.4 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccccc3)C2)n1 10.1021/jm401731q
71626229 125609 0 None 2 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 9 1 6 5.3 CN(CC(=O)O)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421901 125609 0 None 2 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 9 1 6 5.3 CN(CC(=O)O)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
71626493 118975 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1ccc2cccnc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290704 118975 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1ccc2cccnc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
137641119 163788 0 None 28 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 636 12 0 8 6.2 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)/N=C/N(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4073356 163788 0 None 28 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 636 12 0 8 6.2 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)/N=C/N(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
92880 102969 15 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 390 4 1 3 5.6 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL260735 102969 15 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 390 4 1 3 5.6 COC(=O)CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
71461058 89796 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 456 6 0 5 5.8 CCCCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181257 89796 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 456 6 0 5 5.8 CCCCN1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
156705100 189028 0 None -4 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 567 7 0 10 5.5 Cc1oc(=O)oc1COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4783601 189028 0 None -4 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 567 7 0 10 5.5 Cc1oc(=O)oc1COC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
90654590 116736 0 None -1 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 502 6 1 8 2.1 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234571 116736 0 None -1 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 502 6 1 8 2.1 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)nc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
45273910 120336 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 413 3 0 4 5.3 CN1CCN(C(=O)c2cccnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
CHEMBL3321841 120336 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as cAMP level after 48 hrs by fluorescent assay
ChEMBL 413 3 0 4 5.3 CN1CCN(C(=O)c2cccnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1016/j.bmcl.2014.07.026
90644455 119004 0 None 1 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 9 1 8 5.9 CCOC(=O)CNC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290733 119004 0 None 1 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 9 1 8 5.9 CCOC(=O)CNC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
71453901 89779 0 None 10 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 5 0 4 5.8 C=CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181238 89779 0 None 10 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 5 0 4 5.8 C=CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
71450251 89766 28 None -8 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 4 0 4 5.1 Cc1ccc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
CHEMBL2181226 89766 28 None -8 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 399 4 0 4 5.1 Cc1ccc(C)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1021/jm301071h
118103729 171010 0 None - 1 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 676 14 3 7 5.0 O=C(O)CC[C@H](NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
CHEMBL4211123 171010 0 None - 1 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 676 14 3 7 5.0 O=C(O)CC[C@H](NC(=O)CCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)C(=O)O 10.1021/acs.jmedchem.8b00308
118093535 171225 0 None 5 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 10 1.4 O=C(CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4213844 171225 0 None 5 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 10 1.4 O=C(CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
118093557 171438 0 None 3 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 477 5 1 5 4.4 O=C([C@@H]1CSCN1Cc1cc(Cl)c(CO)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4216682 171438 0 None 3 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 477 5 1 5 4.4 O=C([C@@H]1CSCN1Cc1cc(Cl)c(CO)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
71561504 94410 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@@H]1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336222 94410 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC[C@@H]1c1cccnc1 10.1016/j.bmcl.2012.12.076
155669601 187788 0 None 91 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1ccc(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4759025 187788 0 None 91 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1ccc(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
90654569 116713 1 None 2 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234549 116713 1 None 2 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 358 5 1 4 3.0 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
71561755 94058 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 438 6 0 6 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cncs1)C(C)C 10.1016/j.bmcl.2012.12.076
CHEMBL2331604 94058 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 438 6 0 6 5.3 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cncs1)C(C)C 10.1016/j.bmcl.2012.12.076
71626560 118983 0 None -3 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 428 4 0 6 5.1 O=C(c1cnccc1Oc1ccc2ncsc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290712 118983 0 None -3 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 428 4 0 6 5.1 O=C(c1cnccc1Oc1ccc2ncsc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
156705111 189709 0 None -2 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 455 5 1 6 4.9 O=C(O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4792593 189709 0 None -2 2 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 455 5 1 6 4.9 O=C(O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
137638975 163654 0 None - 1 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 546 10 1 7 6.6 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4071870 163654 0 None - 1 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 546 10 1 7 6.6 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
92803 174111 31 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 360 4 1 1 6.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CCCC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL429432 174111 31 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 360 4 1 1 6.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CCCC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
73347897 99487 0 None 6 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 435 5 1 3 6.1 N#CC(NCc1cnccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435925 99487 0 None 6 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 435 5 1 3 6.1 N#CC(NCc1cnccc1-c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
10133 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2015.01.048
145714624 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2015.01.048
4361 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2015.01.048
608 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2015.01.048
CHEMBL240597 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2015.01.048
DB06777 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmc.2015.01.048
155669601 187788 0 None -91 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1ccc(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4759025 187788 0 None -91 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1ccc(Cl)cc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
76318386 112802 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 391 4 0 5 4.3 COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
CHEMBL3132969 112802 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 391 4 0 5 4.3 COc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
44457506 164085 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 374 4 1 1 6.8 C[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL407713 164085 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 374 4 1 1 6.8 C[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
73352467 99490 0 None 8 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 496 5 1 3 5.5 O=S(=O)(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435928 99490 0 None 8 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 496 5 1 3 5.5 O=S(=O)(NCc1cnccc1-c1c(F)cccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
155339364 189495 0 None 1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 583 11 6 8 1.9 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1039/d0md00425a
CHEMBL4789628 189495 0 None 1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 583 11 6 8 1.9 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1039/d0md00425a
118464749 165358 0 None - 1 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 562 7 0 4 8.4 COc1cc(C2(CF)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4091882 165358 0 None - 1 Mouse 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 562 7 0 4 8.4 COc1cc(C2(CF)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
162646016 186250 0 None - 1 Human 4.2 pEC50 = 4.2 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acs.jmedchem.6b01126
CHEMBL4740844 186250 0 None - 1 Human 4.2 pEC50 = 4.2 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acs.jmedchem.6b01126
118464630 165433 0 None - 1 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 574 6 0 4 8.3 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Br)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4092628 165433 0 None - 1 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 574 6 0 4 8.3 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Br)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
5879 213110 49 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]1CCC2=O 10.1021/jm7015864
CHEMBL87285 213110 49 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 290 0 1 2 4.0 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]1CCC2=O 10.1021/jm7015864
44627313 204540 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 510 4 2 2 8.4 C=C(C)C[C@@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
CHEMBL571735 204540 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 510 4 2 2 8.4 C=C(C)C[C@@]1(O)CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
73349426 99489 0 None 12 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 478 5 1 3 5.4 O=S(=O)(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435927 99489 0 None 12 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 478 5 1 3 5.4 O=S(=O)(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
90327488 118994 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 503 5 1 6 5.9 Cc1c(C(=O)O)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290723 118994 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 503 5 1 6 5.9 Cc1c(C(=O)O)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
90654591 116737 0 None -1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 6 2 8 1.7 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cn1 10.1021/jm401731q
CHEMBL3234572 116737 0 None -1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 488 6 2 8 1.7 N#Cc1ccc(CCNC(=O)[C@@H]2CCCN(c3cc(N4CCNCC4)nc(C(F)(F)F)n3)C2)cn1 10.1021/jm401731q
90654580 116725 0 None -4 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 367 5 1 5 2.4 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)ncc1F 10.1021/jm401731q
CHEMBL3234561 116725 0 None -4 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 367 5 1 5 2.4 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)ncc1F 10.1021/jm401731q
118093541 170298 0 None -7 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4202603 170298 0 None -7 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
71660979 170322 0 None 1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4202908 170322 0 None 1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 447 4 0 3 4.9 O=C([C@@H]1C[C@@H](F)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
145967535 171572 0 None -15 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 15 6 10 2.3 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4218315 171572 0 None -15 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 15 6 10 2.3 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
46233054 207501 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1cc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)ccc1Cl 10.1016/j.bmcl.2010.01.003
CHEMBL600020 207501 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1cc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)ccc1Cl 10.1016/j.bmcl.2010.01.003
46232737 207659 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 4 0 3 4.8 CCc1onc(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601428 207659 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 4 0 3 4.8 CCc1onc(-c2ccccc2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232570 207976 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccccc1-c1noc(C)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL603500 207976 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 356 4 0 4 4.6 COc1ccccc1-c1noc(C)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
71661186 171061 0 None 3 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 532 9 1 5 5.6 NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4211892 171061 0 None 3 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 532 9 1 5 5.6 NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
145971348 171349 0 None -1 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 481 4 0 4 5.2 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1C(F)(F)F)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4215354 171349 0 None -1 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 481 4 0 4 5.2 O=C([C@@H]1CSCN1Cc1cc(Cl)ccc1C(F)(F)F)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46233020 206126 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cccc(Cl)c1 10.1016/j.bmcl.2010.01.003
CHEMBL590739 206126 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 360 3 0 3 5.2 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cccc(Cl)c1 10.1016/j.bmcl.2010.01.003
46232626 206283 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.9 Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL591927 206283 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 394 3 0 3 5.9 Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232627 207702 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 378 3 0 3 5.4 Cc1onc(-c2c(F)cccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601670 207702 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 378 3 0 3 5.4 Cc1onc(-c2c(F)cccc2Cl)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
46232984 208202 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cccc(F)c1 10.1016/j.bmcl.2010.01.003
CHEMBL604752 208202 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1cccc(F)c1 10.1016/j.bmcl.2010.01.003
71661224 170919 0 None 1 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 415 4 0 3 4.6 O=C([C@@H]1CCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4210112 170919 0 None 1 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 415 4 0 3 4.6 O=C([C@@H]1CCN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118103718 171300 0 None -1 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 9 1.4 O=C(CCc1cc(Cl)c(CN2C[C@@H](F)C[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4214838 171300 0 None -1 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 682 13 6 9 1.4 O=C(CCc1cc(Cl)c(CN2C[C@@H](F)C[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
44605617 205098 1 None -5 2 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/jm901434t
CHEMBL576138 205098 1 None -5 2 Rat 6.2 pEC50 = 6.2 Functional
Agonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at rat TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/jm901434t
46232411 208156 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 368 5 0 3 5.5 CCCc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL604524 208156 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 368 5 0 3 5.5 CCCc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
71626555 118974 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1ccc2ncccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290703 118974 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 422 4 0 5 5.1 O=C(c1cnccc1Oc1ccc2ncccc2c1)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
58043236 98381 0 None -2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407933 98381 0 None -2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
71561881 94416 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 447 4 0 6 4.9 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1nccn1C 10.1016/j.bmcl.2012.12.076
CHEMBL2336228 94416 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 447 4 0 6 4.9 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1nccn1C 10.1016/j.bmcl.2012.12.076
71561367 94402 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 412 4 0 5 4.6 Cc1nn(C)c(Oc2cccc(F)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336212 94402 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 412 4 0 5 4.6 Cc1nn(C)c(Oc2cccc(F)c2F)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
46196449 83985 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C[C@H](O)[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml200256d
CHEMBL2062554 83985 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C[C@H](O)[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml200256d
CHEMBL2079386 83985 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C[C@H](O)[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml200256d
71626489 118971 0 None -3 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 421 4 0 4 5.7 O=C(c1cnccc1Oc1cccc2ccccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
CHEMBL3290700 118971 0 None -3 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 421 4 0 4 5.7 O=C(c1cnccc1Oc1cccc2ccccc12)N1CCN(C2CC2)c2ccccc21 10.1016/j.ejmech.2014.05.031
77846087 118989 0 None -8 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 537 4 0 5 7.0 Cc1c(Br)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290718 118989 0 None -8 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 537 4 0 5 7.0 Cc1c(Br)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
71453901 89779 0 None -10 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 5 0 4 5.8 C=CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181238 89779 0 None -10 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 439 5 0 4 5.8 C=CCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
156019635 184768 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 387 3 2 3 5.3 CC[C@@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4646200 184768 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 387 3 2 3 5.3 CC[C@@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
89501425 168327 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 539 9 0 5 7.8 CC(C)(c1ccc(Cl)c(Cl)c1)c1cnc(SCCOCc2ccc(C#N)cc2)n1-c1ccc(F)cc1 10.1016/j.bmcl.2018.04.011
CHEMBL4128688 168327 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 539 9 0 5 7.8 CC(C)(c1ccc(Cl)c(Cl)c1)c1cnc(SCCOCc2ccc(C#N)cc2)n1-c1ccc(F)cc1 10.1016/j.bmcl.2018.04.011
10133 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
145714624 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
4361 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
608 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
CHEMBL240597 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
DB06777 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml200256d
10133 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
145714624 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
4361 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
608 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
CHEMBL240597 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
DB06777 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm070633p
10133 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
145714624 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
4361 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
608 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
CHEMBL240597 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
DB06777 7697 78 None -1 4 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/jm7015864
77845284 118997 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 517 7 1 6 5.9 O=C(O)CCc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290726 118997 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 517 7 1 6 5.9 O=C(O)CCc1coc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
118464815 166295 0 None 6 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 528 6 0 4 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4102107 166295 0 None 6 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 528 6 0 4 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
118586298 164805 0 None 2 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 449 8 0 6 6.1 COc1ccc(N(C)c2cnc(SCc3ccccc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4085664 164805 0 None 2 2 Mouse 7.2 pEC50 = 7.2 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 449 8 0 6 6.1 COc1ccc(N(C)c2cnc(SCc3ccccc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
164620833 192337 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 565 6 2 4 7.0 CCNS(=O)(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4863256 192337 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 565 6 2 4 7.0 CCNS(=O)(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
118464664 163969 0 None -2 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 478 6 0 6 5.9 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
CHEMBL4075703 163969 0 None -2 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 478 6 0 6 5.9 COc1cc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)ccc1F 10.1021/acsmedchemlett.7b00116
118464811 163569 0 None 5 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)ccc(OCCOCCOCCN(C)C)c4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4070895 163569 0 None 5 2 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 703 16 0 8 7.9 COc1cc(C2(C)CCCc3nc(SCc4c(F)ccc(OCCOCCOCCN(C)C)c4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
611 9107 75 None 50 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1016/j.bmc.2015.01.048
9903 9107 75 None 50 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1016/j.bmc.2015.01.048
CHEMBL1478 9107 75 None 50 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1016/j.bmc.2015.01.048
2733768 168079 28 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1016/j.ejmech.2015.09.024
CHEMBL412272 168079 28 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1016/j.ejmech.2015.09.024
71461055 89778 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 441 4 0 4 6.1 CC(C)N1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181237 89778 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 441 4 0 4 6.1 CC(C)N1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
118455251 163138 0 None - 1 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4065966 163138 0 None - 1 Mouse 6.2 pEC50 = 6.2 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4c(F)cccc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
156014434 184010 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 373 2 2 3 4.9 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@](C)(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
CHEMBL4635684 184010 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 373 2 2 3 4.9 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@](C)(O)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
44479724 203872 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 472 2 2 3 6.3 CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@H]3[C@H]([C@]4(C)CO4)CC[C@]3(C(=O)O)CC[C@]21C 10.1021/jm900872z
CHEMBL567578 203872 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 472 2 2 3 6.3 CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2CC[C@@H]2[C@H]3[C@H]([C@]4(C)CO4)CC[C@]3(C(=O)O)CC[C@]21C 10.1021/jm900872z
156705091 188986 0 None 20 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 515 7 0 8 5.7 CSCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4783037 188986 0 None 20 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 515 7 0 8 5.7 CSCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
126673445 164327 0 None 47 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 8 0 6 6.7 COc1ccc(N(C)c2c(C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4080290 164327 0 None 47 2 Mouse 8.2 pEC50 = 8.2 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 499 8 0 6 6.7 COc1ccc(N(C)c2c(C)nc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71459276 89777 0 None 10 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 441 5 0 4 6.1 CCCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181236 89777 0 None 10 2 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 441 5 0 4 6.1 CCCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
118577298 167765 0 None 18 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4086463 167765 0 None 18 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4096633 167765 0 None 18 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4116110 167765 0 None 18 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 581 9 0 6 6.4 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
77846087 118989 0 None 8 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 537 4 0 5 7.0 Cc1c(Br)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290718 118989 0 None 8 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 537 4 0 5 7.0 Cc1c(Br)oc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
126673504 164394 0 None 10 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 511 10 0 6 6.9 C=CCN(c1ccc(OC)c(OC)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4081050 164394 0 None 10 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 511 10 0 6 6.9 C=CCN(c1ccc(OC)c(OC)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
71561366 94401 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336211 94401 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
71561884 94423 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 430 6 0 5 5.0 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CC1 10.1016/j.bmcl.2012.12.076
CHEMBL2336236 94423 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 430 6 0 5 5.0 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(Cc1cccnc1)C1CC1 10.1016/j.bmcl.2012.12.076
71459274 89762 0 None 3 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1cccc(Cl)c1)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
CHEMBL2181222 89762 0 None 3 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 405 4 0 4 5.2 O=C(c1cnccc1Oc1cccc(Cl)c1)N1CCN(C2CC2)c2ccccc21 10.1021/jm301071h
46232530 207664 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2cccc(F)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL601440 207664 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 344 3 0 3 4.7 Cc1onc(-c2cccc(F)c2)c1C(=O)N(C)c1ccc(Cl)cc1 10.1016/j.bmcl.2010.01.003
118093541 170298 0 None 7 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4202603 170298 0 None 7 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118103740 170333 0 None 25 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cn1 10.1021/acs.jmedchem.8b00308
CHEMBL4202994 170333 0 None 25 2 Mouse 8.1 pEC50 = 8.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 761 14 6 12 2.0 O=C(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)c1ccc(OCc2cc(Cl)c(CN3CSC[C@H]3C(=O)N3CCN(C4CC4)c4ccccc43)cc2Cl)cn1 10.1021/acs.jmedchem.8b00308
71561882 94421 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 446 7 0 5 5.7 CCC(C)N(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
CHEMBL2336234 94421 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 446 7 0 5 5.7 CCC(C)N(Cc1cccnc1)C(=O)c1c(C)nn(C)c1Oc1cccc(Cl)c1Cl 10.1016/j.bmcl.2012.12.076
121322331 169666 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 497 6 3 5 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NS(C)(=O)=O)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL4173597 169666 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 497 6 3 5 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NS(C)(=O)=O)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
15818 122214 25 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 292 0 2 2 3.8 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
CHEMBL335062 122214 25 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 292 0 2 2 3.8 C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]1CC[C@@H]2O 10.1021/jm7015864
118576999 166484 0 None -17 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 566 9 0 7 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CCN(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4104359 166484 0 None -17 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 566 9 0 7 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(C#CCN(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
71453906 89793 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 442 4 0 5 5.5 CC(C)N1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181254 89793 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 442 4 0 5 5.5 CC(C)N1CCN(C(=O)c2cncnc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
71626832 125603 0 None -2 2 Mouse 4.2 pEC50 = 4.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 511 7 1 5 5.8 O=C(O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421894 125603 0 None -2 2 Mouse 4.2 pEC50 = 4.2 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 511 7 1 5 5.8 O=C(O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
90644444 119006 0 None -4 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 587 8 0 8 6.1 CCOC(=O)CCc1oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290735 119006 0 None -4 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 587 8 0 8 6.1 CCOC(=O)CCc1oc2ccc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
90654578 116723 0 None -3 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1cccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234559 116723 0 None -3 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1cccc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)n1 10.1021/jm401731q
118464680 165439 0 None 46 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1ccc([C@@H]2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4092785 165439 0 None 46 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1ccc([C@@H]2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
90284520 124457 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 434 5 3 3 5.4 CC[C@H]1[C@H](O)[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
CHEMBL3401356 124457 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 434 5 3 3 5.4 CC[C@H]1[C@H](O)[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
44457480 164742 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 495 8 2 3 6.1 CC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL408477 164742 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 495 8 2 3 6.1 CC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)NCCS(=O)(=O)O)[C@H]12 10.1021/jm7015864
14650410 196978 16 None -6 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 265 4 1 3 3.3 OCc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
CHEMBL5174405 196978 16 None -6 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysisAgonist activity against human GPBAR1 expressed in HEK293T cells assessed as transactivation of cAMP-responsive element incubated for 18 hrs by Dual-Luciferase reporter assay based luminometer analysis
ChEMBL 265 4 1 3 3.3 OCc1cccc(OCc2ccc3ccccc3n2)c1 10.1021/acs.jmedchem.1c01078
118464628 164752 0 None - 1 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4cc(F)ccc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4084863 164752 0 None - 1 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 514 6 0 4 7.7 COc1cc(C2CCCc3nc(SCc4cc(F)ccc4F)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
73346391 99499 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 548 6 0 2 8.3 O=C(c1ccc(Cl)cc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435938 99499 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 548 6 0 2 8.3 O=C(c1ccc(Cl)cc1)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
71540073 94066 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331648 94066 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
71540073 94066 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1016/j.bmcl.2012.12.076
CHEMBL2331648 94066 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 437 7 2 6 2.4 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1016/j.bmcl.2012.12.076
136166936 98379 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407931 98379 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
137645502 164437 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 490 7 0 7 5.8 COc1ccc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4081476 164437 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 490 7 0 7 5.8 COc1ccc(C2(C)CCCc3nc(SCc4ncccn4)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
118728411 124454 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 404 5 2 2 6.1 CC[C@H]1C[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCC(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
CHEMBL3401353 124454 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 404 5 2 2 6.1 CC[C@H]1C[C@@H]2[C@H](CC[C@@]3(C)[C@H]2CC[C@@H]3[C@H](C)CCC(=O)O)[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1016/j.bmc.2015.01.048
118586280 165066 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 493 6 0 4 7.7 CN(c1ccc(Cl)c(Cl)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4088938 165066 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 493 6 0 4 7.7 CN(c1ccc(Cl)c(Cl)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
90654570 116715 0 None -2 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 342 5 1 4 2.5 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(F)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234551 116715 0 None -2 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 342 5 1 4 2.5 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(F)cc3)C2)n1 10.1021/jm401731q
447715 203706 68 None 9 7 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/jm070633p
CHEMBL566315 203706 68 None 9 7 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/jm070633p
11258221 165655 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 404 3 3 3 4.3 C[C@H]([C@H]1C[C@H]1C(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL409510 165655 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 404 3 3 3 4.3 C[C@H]([C@H]1C[C@H]1C(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
126016 104227 8 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 390 4 2 2 5.8 CC1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL270105 104227 8 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 390 4 2 2 5.8 CC1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
90654583 116728 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1cc(N2CCN(C)CC2)nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234564 116728 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 447 6 1 7 2.0 Cc1cc(N2CCN(C)CC2)nc(N2CCC[C@@H](C(=O)NCCc3ccc(C#N)cc3)C2)n1 10.1021/jm401731q
71459276 89777 0 None -10 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 441 5 0 4 6.1 CCCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
CHEMBL2181236 89777 0 None -10 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 441 5 0 4 6.1 CCCN1CCN(C(=O)c2cnccc2Oc2cc(Cl)ccc2Cl)c2ccccc21 10.1021/jm301071h
155339369 189561 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 406 5 2 3 5.1 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]21 10.1039/d0md00425a
CHEMBL4790399 189561 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 406 5 2 3 5.1 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]21 10.1039/d0md00425a
137653533 165542 0 None 48 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 702 16 5 9 5.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NC(CCCNC(=N)N)C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4094009 165542 0 None 48 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 702 16 5 9 5.3 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NC(CCCNC(=N)N)C(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
126673452 167932 0 None -257 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 774 19 2 12 5.2 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4087611 167932 0 None -257 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 774 19 2 12 5.2 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4117342 167932 0 None -257 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 774 19 2 12 5.2 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCCN(CCS(=O)(=O)O)CCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
164613452 191720 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 564 6 1 4 7.9 CCCS(=O)(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4853647 191720 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 564 6 1 4 7.9 CCCS(=O)(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
118464803 162563 0 None -15 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 525 7 0 6 6.6 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cncc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4059508 162563 0 None -15 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 525 7 0 6 6.6 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cncc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
44372731 61170 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 362 3 2 2 5.1 CC(CC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
CHEMBL160902 61170 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 362 3 2 2 5.1 CC(CC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/jm7015864
44626704 204510 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 525 4 1 4 8.0 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\OC(=O)CC)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
CHEMBL571482 204510 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 525 4 1 4 8.0 C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC/C(=N\OC(=O)CC)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/jm900872z
118577093 164816 0 None -8 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 497 9 0 7 6.2 COc1ccc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4085777 164816 0 None -8 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 497 9 0 7 6.2 COc1ccc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)cc1 10.1021/acs.jmedchem.6b01873
118464729 163728 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 532 6 0 5 7.4 COc1cc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4072719 163728 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 532 6 0 5 7.4 COc1cc(C2OCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
90644445 118998 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 8 1 9 4.9 CCOC(=O)CNC(=O)c1oc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290727 118998 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 8 1 9 4.9 CCOC(=O)CNC(=O)c1oc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc2c1C 10.1016/j.ejmech.2014.05.031
71541721 94062 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 367 6 2 5 1.8 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C)cc1)CC2 10.1021/ml300277t
CHEMBL2331644 94062 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 367 6 2 5 1.8 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(C)cc1)CC2 10.1021/ml300277t
156011870 184099 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 427 6 2 3 6.3 C=CCCC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
CHEMBL4637054 184099 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 427 6 2 3 6.3 C=CCCC[C@]1(O)C[C@H]2[C@@H]3CC[C@H]([C@H](C)CC#N)[C@@]3(C)CC[C@@H]2[C@@]2(C)CC[C@@H](O)C[C@@H]12 10.1021/acsmedchemlett.9b00636
44457500 162553 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 402 6 1 1 7.6 CCC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
CHEMBL405879 162553 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 402 6 1 1 7.6 CCC[C@H]1C[C@@H]2CCCC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@H]12 10.1021/jm7015864
71626228 125606 0 None -1 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 10 0 7 5.8 CCOC(=O)CN(C)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421898 125606 0 None -1 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 610 10 0 7 5.8 CCOC(=O)CN(C)C(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
44626600 204514 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 551 6 1 4 8.6 C=CCCC(=O)O/N=C1\CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
CHEMBL571515 204514 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assayAgonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay
ChEMBL 551 6 1 4 8.6 C=CCCC(=O)O/N=C1\CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(=C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/jm900872z
145975890 170582 0 None -19 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 16 7 10 2.3 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4206078 170582 0 None -19 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 739 16 7 10 2.3 O=C(NCCCCCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
118103697 170736 0 None -7 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4207801 170736 0 None -7 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 696 13 5 10 1.7 CN(C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)CCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
118093476 170882 0 None -39 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 780 14 6 13 2.1 Cn1c(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
CHEMBL4209669 170882 0 None -39 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 780 14 6 13 2.1 Cn1c(C(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cnc1SCc1cc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.8b00308
44605617 205098 1 None 5 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/jm901434t
CHEMBL576138 205098 1 None 5 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assayAgonist activity at human TGR5 expressed in melanophores assessed as melanosome dispersion by melanophore assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1021/jm901434t
44605617 205098 1 None 5 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1016/j.bmcl.2010.01.003
CHEMBL576138 205098 1 None 5 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 374 3 0 3 5.5 Cc1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1Cl 10.1016/j.bmcl.2010.01.003
46232568 207877 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2010.01.003
CHEMBL602892 207877 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 340 3 0 3 4.9 Cc1cccc(-c2noc(C)c2C(=O)N(C)c2ccc(Cl)cc2)c1 10.1016/j.bmcl.2010.01.003
2733768 168079 28 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1021/jm7015864
CHEMBL412272 168079 28 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1021/jm7015864
118104385 170362 0 None -5 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 648 13 6 10 0.7 O=C(CCc1ccc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)c1)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
CHEMBL4203321 170362 0 None -5 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 648 13 6 10 0.7 O=C(CCc1ccc(Cl)c(CN2CSC[C@H]2C(=O)N2CCN(C3CC3)c3ccccc32)c1)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/acs.jmedchem.8b00308
89651284 171425 0 None 1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 432 6 0 3 5.6 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CCC1 10.1021/acs.jmedchem.8b00308
CHEMBL4216520 171425 0 None 1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 432 6 0 3 5.6 CN(C(=O)[C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)c1ccccc1OC1CCC1 10.1021/acs.jmedchem.8b00308
118093506 171501 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4217450 171501 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 445 4 1 4 3.9 O=C([C@@H]1C[C@H](O)CN1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
46232697 206374 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 416 5 0 3 6.8 CC(C)c1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C(C)C 10.1016/j.bmcl.2010.01.003
CHEMBL592645 206374 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 416 5 0 3 6.8 CC(C)c1onc(-c2ccccc2Cl)c1C(=O)N(c1ccc(Cl)cc1)C(C)C 10.1016/j.bmcl.2010.01.003
118103736 171015 0 None -1 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 453 5 0 4 5.1 O=C([C@@H]1CSCN1Cc1cc(C2CC2)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4211208 171015 0 None -1 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 453 5 0 4 5.1 O=C([C@@H]1CSCN1Cc1cc(C2CC2)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1021/acs.jmedchem.8b00308
118093511 170804 0 None -3 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 388 3 0 2 4.9 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.8b00308
CHEMBL4208655 170804 0 None -3 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level by HTRF assay
ChEMBL 388 3 0 2 4.9 O=C([C@@H]1CCCN1Cc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.8b00308
46232528 207795 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 384 4 0 5 4.4 COC(=O)c1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL602273 207795 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 384 4 0 5 4.4 COC(=O)c1ccc(N(C)C(=O)c2c(-c3ccccc3Cl)noc2C)cc1 10.1016/j.bmcl.2010.01.003
46232413 208198 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 382 3 0 3 5.9 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(C)(C)C)cc1 10.1016/j.bmcl.2010.01.003
CHEMBL604734 208198 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 receptor expressed in human U2-OS cells assessed as changes in response to cAMP level by MRE/CRE-driven luciferase reporter gene assay
ChEMBL 382 3 0 3 5.9 Cc1onc(-c2ccccc2Cl)c1C(=O)N(C)c1ccc(C(C)(C)C)cc1 10.1016/j.bmcl.2010.01.003
90654574 116719 0 None 4 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 376 5 1 4 3.2 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)ncc1F 10.1021/jm401731q
CHEMBL3234555 116719 0 None 4 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 376 5 1 4 3.2 Cc1nc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)ncc1F 10.1021/jm401731q
90654564 116740 0 None -1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234575 116740 0 None -1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 487 6 1 7 2.4 CN1CCN(c2cc(N3CCC[C@H]3C(=O)NCCc3ccc(C#N)cc3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
76318387 112805 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 417 5 0 5 4.9 COc1cccc(-c2noc(C3CC3)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
CHEMBL3132971 112805 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometryAgonist activity at human recombinant TGR5 receptor expressed in doxycycline-induced CHO cells assessed as cAMP accumulation after 30 mins by spectrophotometry
ChEMBL 417 5 0 5 4.9 COc1cccc(-c2noc(C3CC3)c2C(=O)N(C)c2ccc(C(F)(F)F)nc2)c1 10.1039/C2MD20174G
90644455 119004 0 None -1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 9 1 8 5.9 CCOC(=O)CNC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290733 119004 0 None -1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 614 9 1 8 5.9 CCOC(=O)CNC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
90644456 119002 0 None 1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 557 7 0 7 6.8 CCOC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290731 119002 0 None 1 2 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 557 7 0 7 6.8 CCOC(=O)/C=C/c1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
136167004 98378 7 None 1 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407930 98378 7 None 1 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
164618838 192565 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 530 4 1 4 8.4 CCOC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4866697 192565 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 530 4 1 4 8.4 CCOC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
71626834 125608 0 None -2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 10 2 6 5.3 O=C(O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421900 125608 0 None -2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 582 10 2 6 5.3 O=C(O)CCNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
118735265 125607 0 None 1 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 568 9 2 6 4.9 O=C(O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421899 125607 0 None 1 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 568 9 2 6 4.9 O=C(O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
156705085 189766 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 543 10 0 9 5.0 COCCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4793377 189766 0 None 2 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 543 10 0 9 5.0 COCCOCOC(=O)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
118464738 163493 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 564 6 0 4 8.9 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(Cl)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4070183 163493 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 564 6 0 4 8.9 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)c(Cl)c4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
90654576 116721 0 None 1 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccncn2)C1 10.1021/jm401731q
CHEMBL3234557 116721 0 None 1 2 Mouse 5.1 pEC50 = 5.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccncn2)C1 10.1021/jm401731q
90644446 118993 0 None -3 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 559 7 0 8 5.4 COC(=O)CCc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
CHEMBL3290722 118993 0 None -3 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 559 7 0 8 5.4 COC(=O)CCc1coc2cc(Cl)c(C(=O)Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2014.05.031
126673489 163450 0 None 13 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 571 11 0 8 6.5 COC(=O)CCc1nc(SCc2c(F)cccc2F)n(-c2ccc(F)cc2)c1N(C)c1ccc(OC)c(OC)c1 10.1021/acs.jmedchem.6b01873
CHEMBL4069569 163450 0 None 13 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 571 11 0 8 6.5 COC(=O)CCc1nc(SCc2c(F)cccc2F)n(-c2ccc(F)cc2)c1N(C)c1ccc(OC)c(OC)c1 10.1021/acs.jmedchem.6b01873
45483949 10354 35 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml200256d
7048 10354 35 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml200256d
CHEMBL567640 10354 35 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml200256d
44605418 203537 22 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1021/jm901390p
CHEMBL565278 203537 22 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 450 5 4 4 4.3 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2C[C@H](O)[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1021/jm901390p
45483949 10354 35 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmc.2020.115972
7048 10354 35 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmc.2020.115972
CHEMBL567640 10354 35 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1016/j.bmc.2020.115972
73349426 99489 0 None -12 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 478 5 1 3 5.4 O=S(=O)(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435927 99489 0 None -12 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 478 5 1 3 5.4 O=S(=O)(NCc1cnccc1-c1ccccc1F)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
137661039 166268 0 None -21 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 653 13 2 9 5.5 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4101738 166268 0 None -21 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 653 13 2 9 5.5 COc1ccc(SCc2cnc(SCc3c(F)cc(C(=O)NCCS(=O)(=O)O)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
71540078 94071 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 422 6 1 5 2.6 CCc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
CHEMBL2331653 94071 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 422 6 1 5 2.6 CCc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(OC(F)(F)F)cc1)CC2 10.1021/ml300277t
164623929 193020 0 None 31 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 528 5 1 3 8.5 CCCC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
CHEMBL4873587 193020 0 None 31 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 528 5 1 3 8.5 CCCC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CC[C@]3(C)[C@@H]2CC[C@@H]2[C@H]4[C@H](C(C)C)CC[C@]4(C(=O)O)CC[C@]23C)C1(C)C 10.1021/acs.jmedchem.1c00851
156705120 188652 0 None 41 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 503 6 0 7 5.6 O=C(OCCl)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
CHEMBL4778884 188652 0 None 41 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as CRE-driven luciferase reporter gene activity incubated for 5.5 hrs and measured by Steady Glow reagent based luminescence assay
ChEMBL 503 6 0 7 5.6 O=C(OCCl)c1coc2ccc(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1016/j.ejmech.2020.112619
155669600 186555 0 None -87 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4744582 186555 0 None -87 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at mouse TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
71541720 94061 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 353 6 2 5 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccccc1)CC2 10.1021/ml300277t
CHEMBL2331643 94061 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in uninduced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 353 6 2 5 1.5 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccccc1)CC2 10.1021/ml300277t
447715 203706 68 None 9 7 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
CHEMBL566315 203706 68 None 9 7 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assayAgonist activity at human TGR5 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 1 hr by TR-FRET assay
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/acsmedchemlett.7b00318
130361991 176475 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 430 4 2 5 4.9 Cc1noc(CC[C@@H](C)[C@H]2CC[C@H]3[C@H]4[C@H](CC[C@@]32C)[C@@]2(C)CC[C@@H](O)C[C@H]2C[C@H]4O)n1 10.1021/acs.jmedchem.9b00770
CHEMBL4437850 176475 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 430 4 2 5 4.9 Cc1noc(CC[C@@H](C)[C@H]2CC[C@H]3[C@H]4[C@H](CC[C@@]32C)[C@@]2(C)CC[C@@H](O)C[C@H]2C[C@H]4O)n1 10.1021/acs.jmedchem.9b00770
71561619 94415 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 430 4 0 5 5.2 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336227 94415 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 430 4 0 5 5.2 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
439763 164905 22 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acs.jmedchem.9b00770
CHEMBL408701 164905 22 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 483 7 3 4 4.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acs.jmedchem.9b00770
90644447 119008 0 None -2 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 10 1 8 5.8 CCOC(=O)CNC(=O)CCc1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
CHEMBL3290737 119008 0 None -2 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells co-expressing CRE after 5.5 hrs by luciferase reporter gene assay
ChEMBL 616 10 1 8 5.8 CCOC(=O)CNC(=O)CCc1oc2ccc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)c2c1C 10.1016/j.ejmech.2014.05.031
219833 104185 40 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 320 1 2 2 4.4 C[C@H](O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1021/jm7015864
CHEMBL269897 104185 40 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 320 1 2 2 4.4 C[C@H](O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 10.1021/jm7015864
73353940 99494 0 None -27 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 582 6 0 4 7.0 O=C(c1ccccc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435932 99494 0 None -27 2 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 582 6 0 4 7.0 O=C(c1ccccc1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
126673504 164394 0 None -10 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 511 10 0 6 6.9 C=CCN(c1ccc(OC)c(OC)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4081050 164394 0 None -10 2 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 511 10 0 6 6.9 C=CCN(c1ccc(OC)c(OC)c1)c1cnc(SCc2c(F)cccc2F)n1-c1ccc(F)cc1 10.1021/acs.jmedchem.6b01873
164612114 191409 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 512 3 2 3 7.7 CC(C)[C@@H]1CC[C@]2(N)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
CHEMBL4849469 191409 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assayAgonist activity at N-terminal HA-tagged human TGR5 expressed in HEK293 cells assessed as reduction in intracellular cAMP levels incubated for 30 mins by Lance Ultra cAMP assay
ChEMBL 512 3 2 3 7.7 CC(C)[C@@H]1CC[C@]2(N)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@@H](OC(=O)NC6CC6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 10.1021/acs.jmedchem.1c00851
5284055 104350 4 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 394 4 4 4 3.4 C[C@H](CCCO)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
CHEMBL270703 104350 4 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in CHO cells by luciferase assayAgonist activity at human TGR5 expressed in CHO cells by luciferase assay
ChEMBL 394 4 4 4 3.4 C[C@H](CCCO)[C@H]1CC[C@H]2[C@H]3[C@H](C[C@H](O)[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O 10.1021/jm7015864
70686470 83984 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C[C@@H](O)[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml200256d
CHEMBL2062553 83984 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C[C@@H](O)[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml200256d
CHEMBL2079385 83984 0 None - 1 Human 4.1 pEC50 = 4.1 Functional
Agonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysisAgonist activity at TGR5 expressed in NCI-H716 cells assessed as cAMP level after 60 mins by FRET analysis
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](C[C@@H](O)[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml200256d
90654571 116716 0 None -2 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 402 5 1 4 3.1 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Br)cc3)C2)n1 10.1021/jm401731q
CHEMBL3234552 116716 0 None -2 2 Mouse 7.1 pEC50 = 7.1 Functional
Agonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at mouse TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 402 5 1 4 3.1 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Br)cc3)C2)n1 10.1021/jm401731q
136166933 98390 0 None 3 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 394 5 1 3 5.6 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407949 98390 0 None 3 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP productionAgonist activity at GPBAR1 in human NCI-H716 cells assessed as stimulation of cAMP production
ChEMBL 394 5 1 3 5.6 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
3223370 116711 2 None 1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)C1CCCN(c2ncccn2)C1 10.1021/jm401731q
CHEMBL3234546 116711 2 None 1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 344 5 1 4 2.7 O=C(NCCc1ccc(Cl)cc1)C1CCCN(c2ncccn2)C1 10.1021/jm401731q
118577011 163765 0 None -20 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 489 7 0 5 7.0 COc1cc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)ccc1Cl 10.1021/acs.jmedchem.6b01873
CHEMBL4073081 163765 0 None -20 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 489 7 0 5 7.0 COc1cc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)ccc1Cl 10.1021/acs.jmedchem.6b01873
118455249 163476 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 530 6 0 4 8.2 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
CHEMBL4069934 163476 0 None - 1 Mouse 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 530 6 0 4 8.2 COc1cc(C2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)ccc1Cl 10.1021/acsmedchemlett.7b00116
2733768 168079 28 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1016/j.ejmech.2015.09.024
CHEMBL412272 168079 28 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assayAgonist activity at human TGR5 Y89A mutant expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay
ChEMBL 499 7 4 5 3.4 C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@@]21C 10.1016/j.ejmech.2015.09.024
73346390 99492 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 533 7 0 4 7.8 N#CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccco1)Cc1cnccc1-c1ccccc1F 10.1016/j.ejmech.2013.07.050
CHEMBL2435930 99492 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 533 7 0 4 7.8 N#CC(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(Cc1ccco1)Cc1cnccc1-c1ccccc1F 10.1016/j.ejmech.2013.07.050
71541722 94063 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 381 7 2 5 2.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC)cc1)CC2 10.1021/ml300277t
CHEMBL2331645 94063 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassayAgonist activity at human TGR5 expressed in deoxycycline-induced Flp-In-CHO-TO cells assessed as increase in intracellular cAMP measured after 48 hrs by HTRF competitive immunoassay
ChEMBL 381 7 2 5 2.1 CCNc1nc2c(c(C(N)=O)n1)CN(C(=O)CCc1ccc(CC)cc1)CC2 10.1021/ml300277t
155669600 186555 0 None 87 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
CHEMBL4744582 186555 0 None 87 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assayAgonist activity at human TGR5 transfected in HEK293T cells assessed intracellular cAMP level by HTRF assay
ChEMBL 426 4 0 4 4.9 O=C(c1cncn1Cc1cc(Cl)ccc1Cl)N1CCN(C2CC2)c2ccccc21 10.1016/j.bmc.2020.115972
118576918 167910 0 None 24 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 654 13 0 8 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4078612 167910 0 None 24 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 654 13 0 8 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4117224 167910 0 None 24 2 Mouse 8.0 pEC50 = 8.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 654 13 0 8 6.3 COc1ccc(N(C)c2cnc(SCc3c(F)cc(OCCC[N+]45CCN(CC4)CC5)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
45483949 10354 35 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/acs.jmedchem.6b01126
7048 10354 35 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/acs.jmedchem.6b01126
CHEMBL567640 10354 35 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayAgonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assay
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/acs.jmedchem.6b01126
118586279 162631 0 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 535 8 0 6 7.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(C(F)(F)F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
CHEMBL4060122 162631 0 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 535 8 0 6 7.2 COc1ccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(C(F)(F)F)cc2)cc1OC 10.1021/acs.jmedchem.6b01873
118586276 162951 0 None 10 2 Mouse 7.0 pEC50 = 7.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1cccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)c1 10.1021/acs.jmedchem.6b01873
CHEMBL4063932 162951 0 None 10 2 Mouse 7.0 pEC50 = 7.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1cccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)c1 10.1021/acs.jmedchem.6b01873
73355479 99496 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 452 5 0 2 6.3 CC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
CHEMBL2435934 99496 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 452 5 0 2 6.3 CC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)Cc1cnccc1-c1ccccc1 10.1016/j.ejmech.2013.07.050
73353941 99495 0 None -28 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 572 6 0 5 6.6 O=C(c1ccco1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
CHEMBL2435933 99495 0 None -28 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assayAgonist activity at mouse TGR5 expressed in HEK293 cells assessed CRE-induced luciferase activity after 5.5 hrs by reporter gene assay
ChEMBL 572 6 0 5 6.6 O=C(c1ccco1)N(Cc1cnccc1-c1ccccc1F)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.ejmech.2013.07.050
90283905 124458 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 402 4 1 3 5.1 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@@H]3C(=O)C[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)O 10.1016/j.bmc.2015.01.048
CHEMBL3401357 124458 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assayAgonist activity at human GPBAR1 expressed in HEK293 cells assessed as increase in intracellular cAMP level after 30 mins by cAMP-Glo assay
ChEMBL 402 4 1 3 5.1 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@@H]3C(=O)C[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)O 10.1016/j.bmc.2015.01.048
71561502 94409 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 376 4 0 5 4.3 Cc1nn(C)c(Oc2ccccc2)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336220 94409 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 376 4 0 5 4.3 Cc1nn(C)c(Oc2ccccc2)c1C(=O)N1CCCCC1c1cccnc1 10.1016/j.bmcl.2012.12.076
71561883 94422 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 404 5 0 5 4.5 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(C)Cc1cccnc1 10.1016/j.bmcl.2012.12.076
CHEMBL2336235 94422 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycyclineAgonist activity at human TGR5 receptor in CHO cells assessed as elevation of cAMP level by uninduced cAMP detection method in absence of doxycycline
ChEMBL 404 5 0 5 4.5 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N(C)Cc1cccnc1 10.1016/j.bmcl.2012.12.076
118464747 165113 0 None -4 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 743 19 2 10 6.0 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)NCCOCCOCCOCCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4089352 165113 0 None -4 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assayAgonist activity at TGR5 in human NCI-H716 cells assessed as increase in cAMP accumulation after 40 mins by HTRF assay
ChEMBL 743 19 2 10 6.0 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)NCCOCCOCCOCCO)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
90654575 116720 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 343 5 1 3 3.3 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccccn2)C1 10.1021/jm401731q
CHEMBL3234556 116720 0 None 1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 343 5 1 3 3.3 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ccccn2)C1 10.1021/jm401731q
90654579 116724 0 None 5 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)c1 10.1021/jm401731q
CHEMBL3234560 116724 0 None 5 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 357 5 1 3 3.6 Cc1ccnc(N2CCC[C@@H](C(=O)NCCc3ccc(Cl)cc3)C2)c1 10.1021/jm401731q
156018124 184669 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 449 4 2 3 6.1 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@](O)(Cc4ccccc4)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
CHEMBL4644760 184669 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assayAgonist activity at human GPBAR1 receptor expressed in HEK293T cells after 18 hrs by cAMP response element driven renilla-luciferase dual reporter gene assay
ChEMBL 449 4 2 3 6.1 C[C@H](CC#N)[C@H]1CC[C@H]2[C@@H]3C[C@](O)(Cc4ccccc4)[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1021/acsmedchemlett.9b00636
137630926 167914 0 None 3 2 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 681 15 1 8 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)NCCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4086239 167914 0 None 3 2 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 681 15 1 8 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)NCCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4117239 167914 0 None 3 2 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 681 15 1 8 6.3 COc1ccc(SCc2cnc(SCc3c(F)cc(S(=O)(=O)NCCC[N+](C)(C)C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
118577093 164816 0 None 8 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 497 9 0 7 6.2 COc1ccc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)cc1 10.1021/acs.jmedchem.6b01873
CHEMBL4085777 164816 0 None 8 2 Mouse 6.0 pEC50 = 6.0 Functional
Agonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at mouse TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 497 9 0 7 6.2 COc1ccc(-n2c(N(C)c3ccc(OC)c(OC)c3)cnc2SCc2c(F)cccc2F)cc1 10.1021/acs.jmedchem.6b01873
118455177 163052 0 None - 1 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1ccc([C@H]2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4065113 163052 0 None - 1 Mouse 5.0 pEC50 = 5.0 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 526 7 0 5 7.6 COc1ccc([C@H]2CCCc3nc(SCc4c(F)cccc4Cl)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
89501618 168335 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 563 11 0 8 5.2 COc1ccc(C(C)(C)c2cnc(S(=O)(=O)CCOCc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
CHEMBL4128816 168335 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHOK1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 563 11 0 8 5.2 COc1ccc(C(C)(C)c2cnc(S(=O)(=O)CCOCc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2018.04.011
118464718 165029 0 None 36 2 Mouse 7.0 pEC50 = 7.0 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 568 8 1 6 6.9 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)O)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
CHEMBL4088541 165029 0 None 36 2 Mouse 7.0 pEC50 = 7.0 Functional
Agonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric methodAgonist activity at TGR5 in mouse STC1 cells assessed as increase in cAMP accumulation after 40 mins by mass spectrometric method
ChEMBL 568 8 1 6 6.9 COc1ccc(C2(C)CCCc3nc(SCc4c(F)cc(C(=O)O)cc4F)n(-c4ccc(F)cc4)c32)cc1OC 10.1021/acsmedchemlett.7b00116
44427762 100003 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 434 5 3 3 5.4 CC[C@@H]1C2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1021/jm070633p
CHEMBL244785 100003 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells after 5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 434 5 3 3 5.4 CC[C@@H]1C2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1021/jm070633p
45483944 203792 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](O)C(=O)O)[C@@H]2[C@@H]1O 10.1021/jm901390p
CHEMBL566985 203792 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO cells assessed as increase in CRE-driven gene expression by luciferase reporter gene assay
ChEMBL 436 5 4 4 4.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](O)C(=O)O)[C@@H]2[C@@H]1O 10.1021/jm901390p
90654573 116718 0 None 1 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 362 5 1 4 2.8 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncc(F)cn2)C1 10.1021/jm401731q
CHEMBL3234554 116718 0 None 1 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assayAgonist activity at human TGR5 expressed in Jurkat cells assessed as intracellular cAMP level after 1 hr by HTRF assay
ChEMBL 362 5 1 4 2.8 O=C(NCCc1ccc(Cl)cc1)[C@@H]1CCCN(c2ncc(F)cn2)C1 10.1021/jm401731q
71561616 94412 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1ccccn1 10.1016/j.bmcl.2012.12.076
CHEMBL2336224 94412 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assayAgonist activity at doxycycline-promoter regulated overexpressed human TGR5 receptor in CHO cells assessed as elevation of cAMP level by induced-cAMP assay
ChEMBL 444 4 0 5 5.6 Cc1nn(C)c(Oc2cccc(Cl)c2Cl)c1C(=O)N1CCCCC1c1ccccn1 10.1016/j.bmcl.2012.12.076
118735265 125607 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 568 9 2 6 4.9 O=C(O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
CHEMBL3421899 125607 0 None -1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assayAgonist activity at human TGR5 expressed in HEK293 cells incubated for 5.5 hrs by CRE-driven luciferase reporter gene assay
ChEMBL 568 9 2 6 4.9 O=C(O)CNC(=O)CCc1cc(Cl)c(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/jm500829b
130361906 164756 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 473 6 0 3 6.3 CO[C@@H]1CC[C@@]2(C)[C@@H](C1)C[C@@H](OC)[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@H]2[C@H](C)CCC(=O)N1CCCC1 10.1021/acs.jmedchem.9b00770
CHEMBL4084918 164756 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assayAgonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay
ChEMBL 473 6 0 3 6.3 CO[C@@H]1CC[C@@]2(C)[C@@H](C1)C[C@@H](OC)[C@@H]1[C@@H]2CC[C@@]2(C)[C@H]1CC[C@@H]2[C@H](C)CCC(=O)N1CCCC1 10.1021/acs.jmedchem.9b00770
137634963 162660 0 None 21 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 529 10 0 6 6.3 COc1ccc(N(C=O)Cc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
CHEMBL4060463 162660 0 None 21 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric methodAgonist activity at TGR5 in STC1 cells derived from double transgenic mouse expressing rat insulin promoters linked to SV40 large T antigen and to polyomavirus small T antigen assessed as increase in cAMP level after 40 mins by mass spectrometric method
ChEMBL 529 10 0 6 6.3 COc1ccc(N(C=O)Cc2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1016/j.bmcl.2017.02.069
118586276 162951 0 None -10 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1cccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)c1 10.1021/acs.jmedchem.6b01873
CHEMBL4063932 162951 0 None -10 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assayAgonist activity at human TGR5 transfected in HEK293 cells assessed as cAMP accumulation after overnight incubation by luciferase reporter gene assay
ChEMBL 455 7 0 5 6.4 COc1cccc(N(C)c2cnc(SCc3c(F)cccc3F)n2-c2ccc(F)cc2)c1 10.1021/acs.jmedchem.6b01873
52941357 24377 0 None 7 2 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 390 7 1 5 5.3 COc1ccc(CNCc2cc3ccc(OC)cc3nc2-c2ccsc2)cc1 10.1016/j.bmcl.2010.08.014
CHEMBL1258196 24377 0 None 7 2 Human 6.0 pIC50 = 6.0 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 390 7 1 5 5.3 COc1ccc(CNCc2cc3ccc(OC)cc3nc2-c2ccsc2)cc1 10.1016/j.bmcl.2010.08.014
52945302 24342 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 360 6 1 4 5.3 COc1ccc2cc(CNCc3ccccc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258081 24342 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 360 6 1 4 5.3 COc1ccc2cc(CNCc3ccccc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52949938 24442 0 None -4 2 Mouse 4.9 pIC50 = 4.9 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3cccc(Br)c3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258424 24442 0 None -4 2 Mouse 4.9 pIC50 = 4.9 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3cccc(Br)c3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
17755104 24341 0 None 1 2 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 434 5 3 3 5.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1016/j.bmcl.2010.08.014
CHEMBL1258080 24341 0 None 1 2 Human 6.9 pIC50 = 6.9 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 434 5 3 3 5.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1016/j.bmcl.2010.08.014
52946277 24206 0 None -19 2 Mouse 5.8 pIC50 = 5.8 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257612 24206 0 None -19 2 Mouse 5.8 pIC50 = 5.8 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2c1 10.1016/j.bmcl.2010.08.014
17755104 24341 0 None -1 2 Mouse 6.6 pIC50 = 6.6 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 434 5 3 3 5.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1016/j.bmcl.2010.08.014
CHEMBL1258080 24341 0 None -1 2 Mouse 6.6 pIC50 = 6.6 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 434 5 3 3 5.4 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)C[C@H](C)C(=O)O)[C@@H]2[C@@H]1O 10.1016/j.bmcl.2010.08.014
52948571 24059 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 437 7 1 5 5.0 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ncco3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257142 24059 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 437 7 1 5 5.0 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ncco3)nc2c1 10.1016/j.bmcl.2010.08.014
136002656 24165 0 None 18 2 Mouse 6.6 pIC50 = 6.6 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257491 24165 0 None 18 2 Mouse 6.6 pIC50 = 6.6 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52949938 24442 0 None 4 2 Human 5.6 pIC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3cccc(Br)c3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258424 24442 0 None 4 2 Human 5.6 pIC50 = 5.6 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3cccc(Br)c3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52946791 24244 0 None 1 2 Mouse 6.5 pIC50 = 6.5 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 468 7 2 5 5.8 COc1cc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2cc1O 10.1016/j.bmcl.2010.08.014
CHEMBL1257732 24244 0 None 1 2 Mouse 6.5 pIC50 = 6.5 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 468 7 2 5 5.8 COc1cc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2cc1O 10.1016/j.bmcl.2010.08.014
24969872 24441 0 None -10 2 Mouse 5.5 pIC50 = 5.5 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258423 24441 0 None -10 2 Mouse 5.5 pIC50 = 5.5 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
26404327 24407 0 None -38 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 7 1 4 6.0 COc1ccc2cc(CNCCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258311 24407 0 None -38 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 7 1 4 6.0 COc1ccc2cc(CNCCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
24969952 24552 0 None -85 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccncc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258758 24552 0 None -85 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccncc3)nc2c1 10.1016/j.bmcl.2010.08.014
52941356 24376 0 None -4 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 374 6 1 4 5.6 COc1ccc2cc(CNCc3ccc(C)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258195 24376 0 None -4 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 374 6 1 4 5.6 COc1ccc2cc(CNCc3ccc(C)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52945144 24514 0 None -7 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccco3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258645 24514 0 None -7 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccco3)nc2c1 10.1016/j.bmcl.2010.08.014
52946791 24244 0 None -1 2 Human 6.4 pIC50 = 6.4 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 468 7 2 5 5.8 COc1cc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2cc1O 10.1016/j.bmcl.2010.08.014
CHEMBL1257732 24244 0 None -1 2 Human 6.4 pIC50 = 6.4 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 468 7 2 5 5.8 COc1cc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2cc1O 10.1016/j.bmcl.2010.08.014
42429922 24406 3 None -7 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 394 6 1 4 5.9 COc1ccc2cc(CNCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258310 24406 3 None -7 2 Mouse 5.4 pIC50 = 5.4 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 394 6 1 4 5.9 COc1ccc2cc(CNCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
24969952 24552 0 None 85 2 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccncc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258758 24552 0 None 85 2 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccncc3)nc2c1 10.1016/j.bmcl.2010.08.014
52946134 24093 0 None 2 2 Human 5.4 pIC50 = 5.4 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 466 8 1 4 6.5 CCOc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257260 24093 0 None 2 2 Human 5.4 pIC50 = 5.4 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 466 8 1 4 6.5 CCOc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52948780 24477 0 None -7 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccs3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258530 24477 0 None -7 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccs3)nc2c1 10.1016/j.bmcl.2010.08.014
52950002 24515 0 None 16 2 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 446 7 1 3 6.0 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccccc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258646 24515 0 None 16 2 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 446 7 1 3 6.0 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccccc3)nc2c1 10.1016/j.bmcl.2010.08.014
52945144 24514 0 None 7 2 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccco3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258645 24514 0 None 7 2 Human 6.3 pIC50 = 6.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccco3)nc2c1 10.1016/j.bmcl.2010.08.014
52947341 24060 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 6 1 3 6.4 Cc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257143 24060 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 6 1 3 6.4 Cc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52948858 24587 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 453 7 1 5 5.5 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3nccs3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258878 24587 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 453 7 1 5 5.5 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3nccs3)nc2c1 10.1016/j.bmcl.2010.08.014
24969527 24553 0 None -77 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccnc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258759 24553 0 None -77 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccnc3)nc2c1 10.1016/j.bmcl.2010.08.014
136002656 24165 0 None -18 2 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257491 24165 0 None -18 2 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
221493 7708 87 None -2 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
3096 7708 87 None -2 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
609 7708 87 None -2 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
CHEMBL205596 7708 87 None -2 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
DB02659 7708 87 None -2 2 Mouse 5.3 pIC50 = 5.3 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
52941381 24164 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 422 6 1 3 6.1 Brc1ccc(CCNCc2cc3ccccc3nc2-c2ccsc2)cc1 10.1016/j.bmcl.2010.08.014
CHEMBL1257490 24164 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 422 6 1 3 6.1 Brc1ccc(CCNCc2cc3ccccc3nc2-c2ccsc2)cc1 10.1016/j.bmcl.2010.08.014
42429922 24406 3 None 7 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 394 6 1 4 5.9 COc1ccc2cc(CNCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258310 24406 3 None 7 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 394 6 1 4 5.9 COc1ccc2cc(CNCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52948780 24477 0 None 7 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccs3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258530 24477 0 None 7 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccs3)nc2c1 10.1016/j.bmcl.2010.08.014
221493 7708 87 None 2 2 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
3096 7708 87 None 2 2 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
609 7708 87 None 2 2 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
CHEMBL205596 7708 87 None 2 2 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
DB02659 7708 87 None 2 2 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1016/j.bmcl.2010.08.014
52946355 24478 1 None -8 2 Mouse 5.2 pIC50 = 5.2 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccoc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258531 24478 1 None -8 2 Mouse 5.2 pIC50 = 5.2 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccoc3)nc2c1 10.1016/j.bmcl.2010.08.014
24969872 24441 0 None 10 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258423 24441 0 None 10 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 452 7 1 4 6.1 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
24969527 24553 0 None 77 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccnc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258759 24553 0 None 77 2 Human 7.2 pIC50 = 7.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 447 7 1 4 5.4 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3cccnc3)nc2c1 10.1016/j.bmcl.2010.08.014
52941296 24092 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 456 6 1 3 6.7 Clc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257259 24092 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 456 6 1 3 6.7 Clc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52946355 24478 1 None 8 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccoc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258531 24478 1 None 8 2 Human 6.2 pIC50 = 6.2 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 436 7 1 4 5.6 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccoc3)nc2c1 10.1016/j.bmcl.2010.08.014
52950002 24515 0 None -16 2 Mouse 5.1 pIC50 = 5.1 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 446 7 1 3 6.0 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccccc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258646 24515 0 None -16 2 Mouse 5.1 pIC50 = 5.1 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 446 7 1 3 6.0 COc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccccc3)nc2c1 10.1016/j.bmcl.2010.08.014
52946277 24206 0 None 19 2 Human 7.1 pIC50 = 7.1 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257612 24206 0 None 19 2 Human 7.1 pIC50 = 7.1 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 438 6 2 4 5.8 Oc1ccc2nc(-c3ccsc3)c(CNCCc3ccc(Br)cc3)cc2c1 10.1016/j.bmcl.2010.08.014
52941357 24377 0 None -7 2 Mouse 5.1 pIC50 = 5.1 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 390 7 1 5 5.3 COc1ccc(CNCc2cc3ccc(OC)cc3nc2-c2ccsc2)cc1 10.1016/j.bmcl.2010.08.014
CHEMBL1258196 24377 0 None -7 2 Mouse 5.1 pIC50 = 5.1 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 390 7 1 5 5.3 COc1ccc(CNCc2cc3ccc(OC)cc3nc2-c2ccsc2)cc1 10.1016/j.bmcl.2010.08.014
52941356 24376 0 None 4 2 Human 6.1 pIC50 = 6.1 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 374 6 1 4 5.6 COc1ccc2cc(CNCc3ccc(C)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258195 24376 0 None 4 2 Human 6.1 pIC50 = 6.1 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 374 6 1 4 5.6 COc1ccc2cc(CNCc3ccc(C)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
52946134 24093 0 None -2 2 Mouse 5.0 pIC50 = 5.0 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 466 8 1 4 6.5 CCOc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1257260 24093 0 None -2 2 Mouse 5.0 pIC50 = 5.0 Functional
Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 466 8 1 4 6.5 CCOc1ccc2cc(CNCCc3ccc(Br)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
26404327 24407 0 None 38 2 Human 7.0 pIC50 = 7.0 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 7 1 4 6.0 COc1ccc2cc(CNCCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
CHEMBL1258311 24407 0 None 38 2 Human 7.0 pIC50 = 7.0 Functional
Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelAgonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP level
ChEMBL 408 7 1 4 6.0 COc1ccc2cc(CNCCc3ccc(Cl)cc3)c(-c3ccsc3)nc2c1 10.1016/j.bmcl.2010.08.014
221493 7708 87 None 2 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
3096 7708 87 None 2 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
609 7708 87 None 2 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
CHEMBL205596 7708 87 None 2 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
DB02659 7708 87 None 2 2 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
10133 7697 78 None -1 4 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
145714624 7697 78 None -1 4 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
4361 7697 78 None -1 4 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
608 7697 78 None -1 4 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
CHEMBL240597 7697 78 None -1 4 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
DB06777 7697 78 None -1 4 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C None
31401 54883 80 None - 1 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C None
CHEMBL1551 54883 80 None - 1 Human 8.3 pEC50 = 8.3 Functional
NoneNone
Drug Central 392 4 3 3 4.5 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@@]21C None
222528 8150 81 None 144 2 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
4988 8150 81 None 144 2 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
610 8150 81 None 144 2 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
CHEMBL406393 8150 81 None 144 2 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
DB03619 8150 81 None 144 2 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C None
447715 203706 68 None 9 7 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O None
CHEMBL566315 203706 68 None 9 7 Human 8.2 pEC50 = 8.2 Functional
NoneNone
Drug Central 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O None
60166172 7781 0 None 79 2 Human 9.4 pEC50 = 9.4 Functional
Assessed in a cAMP production assay in Jurkat cells expressing exogenous hGPBAR1.Assessed in a cAMP production assay in Jurkat cells expressing exogenous hGPBAR1.
Guide to Pharmacology 387 4 1 2 5.5 Fc1ccc(c(c1)C)N(C(=O)c1ccncc1C)Cc1cccc2c1cc([nH]2)C 25411721
9078 7781 0 None 79 2 Human 9.4 pEC50 = 9.4 Functional
Assessed in a cAMP production assay in Jurkat cells expressing exogenous hGPBAR1.Assessed in a cAMP production assay in Jurkat cells expressing exogenous hGPBAR1.
Guide to Pharmacology 387 4 1 2 5.5 Fc1ccc(c(c1)C)N(C(=O)c1ccncc1C)Cc1cccc2c1cc([nH]2)C 25411721
60166172 7781 0 None -79 2 Mouse 7.5 pEC50 = 7.5 Functional
Assessed in a cAMP production assay in Jurkat cells expressing exogenous mGPBAR1.Assessed in a cAMP production assay in Jurkat cells expressing exogenous mGPBAR1.
Guide to Pharmacology 387 4 1 2 5.5 Fc1ccc(c(c1)C)N(C(=O)c1ccncc1C)Cc1cccc2c1cc([nH]2)C 25411721
9078 7781 0 None -79 2 Mouse 7.5 pEC50 = 7.5 Functional
Assessed in a cAMP production assay in Jurkat cells expressing exogenous mGPBAR1.Assessed in a cAMP production assay in Jurkat cells expressing exogenous mGPBAR1.
Guide to Pharmacology 387 4 1 2 5.5 Fc1ccc(c(c1)C)N(C(=O)c1ccncc1C)Cc1cccc2c1cc([nH]2)C 25411721
10198 8835 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Measured by TR-FRET assay.Measured by TR-FRET assay.
Guide to Pharmacology 471 6 2 6 4.1 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)CC[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)[C@@H](CCOS(=O)(=O)[O-])C 20631053
137321169 8835 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Measured by TR-FRET assay.Measured by TR-FRET assay.
Guide to Pharmacology 471 6 2 6 4.1 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)CC[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)[C@@H](CCOS(=O)(=O)[O-])C 20631053
23642339 8835 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Measured by TR-FRET assay.Measured by TR-FRET assay.
Guide to Pharmacology 471 6 2 6 4.1 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)CC[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)[C@@H](CCOS(=O)(=O)[O-])C 20631053
CHEMBL3306873 8835 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Measured by TR-FRET assay.Measured by TR-FRET assay.
Guide to Pharmacology 471 6 2 6 4.1 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)CC[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)[C@@H](CCOS(=O)(=O)[O-])C 20631053
11696 10880 0 None 31 2 Human 7.1 pEC50 = 7.1 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5
Guide to Pharmacology 528 5 1 3 8.5 C[C@]12C(CC[C@]3(C)[C@@H]1CC[C@H]1[C@@]3(C)CC[C@]3(C(=O)O)[C@@H]1[C@H](C(C)C)CC3)C(C)(C)[C@H](OC(=O)CCC)CC2 34406006
156587567 10880 0 None 31 2 Human 7.1 pEC50 = 7.1 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5
Guide to Pharmacology 528 5 1 3 8.5 C[C@]12C(CC[C@]3(C)[C@@H]1CC[C@H]1[C@@]3(C)CC[C@]3(C(=O)O)[C@@H]1[C@H](C(C)C)CC3)C(C)(C)[C@H](OC(=O)CCC)CC2 34406006
11697 7759 0 None 134 2 Human 8.2 pEC50 = 8.2 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5
Guide to Pharmacology 543 4 3 4 6.8 CC1(C)[C@H](OC(=O)NC2CC2)CC[C@@]2(C)C1CC[C@]1(C)C2CCC2[C@@]1(C)CC[C@]1(C(=O)O)C2[C@H]([C@H](C)O)CC1 34406006
156304705 7759 0 None 134 2 Human 8.2 pEC50 = 8.2 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing hTGR5
Guide to Pharmacology 543 4 3 4 6.8 CC1(C)[C@H](OC(=O)NC2CC2)CC[C@@]2(C)C1CC[C@]1(C)C2CCC2[C@@]1(C)CC[C@]1(C(=O)O)C2[C@H]([C@H](C)O)CC1 34406006
11696 10880 0 None -31 2 Mouse 5.6 pEC50 = 5.6 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5
Guide to Pharmacology 528 5 1 3 8.5 C[C@]12C(CC[C@]3(C)[C@@H]1CC[C@H]1[C@@]3(C)CC[C@]3(C(=O)O)[C@@H]1[C@H](C(C)C)CC3)C(C)(C)[C@H](OC(=O)CCC)CC2 34406006
156587567 10880 0 None -31 2 Mouse 5.6 pEC50 = 5.6 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5
Guide to Pharmacology 528 5 1 3 8.5 C[C@]12C(CC[C@]3(C)[C@@H]1CC[C@H]1[C@@]3(C)CC[C@]3(C(=O)O)[C@@H]1[C@H](C(C)C)CC3)C(C)(C)[C@H](OC(=O)CCC)CC2 34406006
11697 7759 0 None -134 2 Mouse 6.0 pEC50 = 6.0 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5
Guide to Pharmacology 543 4 3 4 6.8 CC1(C)[C@H](OC(=O)NC2CC2)CC[C@@]2(C)C1CC[C@]1(C)C2CCC2[C@@]1(C)CC[C@]1(C(=O)O)C2[C@H]([C@H](C)O)CC1 34406006
156304705 7759 0 None -134 2 Mouse 6.0 pEC50 = 6.0 Functional
Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5Measuring receptor activation as cAMP accumulation in HEK293 cells expressing mTGR5
Guide to Pharmacology 543 4 3 4 6.8 CC1(C)[C@H](OC(=O)NC2CC2)CC[C@@]2(C)C1CC[C@]1(C)C2CCC2[C@@]1(C)CC[C@]1(C(=O)O)C2[C@H]([C@H](C)O)CC1 34406006
10494 9690 81 None - 1 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 1 2 2 7.2 O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C 17825251
3306 9690 81 None - 1 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 1 2 2 7.2 O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C 17825251
CHEMBL168 9690 81 None - 1 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 1 2 2 7.2 O[C@H]1CC[C@]2([C@H](C1(C)C)CC[C@@]1([C@@H]2CC=C2[C@@]1(C)CC[C@@]1([C@H]2CC(C)(C)CC1)C(=O)O)C)C 17825251
3945 7412 92 None - 1 Human 6.0 pEC50 = 6.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 19911773
64971 7412 92 None - 1 Human 6.0 pEC50 = 6.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 19911773
CHEMBL269277 7412 92 None - 1 Human 6.0 pEC50 = 6.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 19911773
DB12480 7412 92 None - 1 Human 6.0 pEC50 = 6.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology 456 2 2 2 7.1 CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O 19911773
45483949 10354 35 None 2 2 Mouse 6.1 pEC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 20014870
7048 10354 35 None 2 2 Mouse 6.1 pEC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 20014870
CHEMBL567640 10354 35 None 2 2 Mouse 6.1 pEC50 = 6.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 20014870
222528 8150 81 None 144 2 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
4988 8150 81 None 144 2 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
610 8150 81 None 144 2 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
CHEMBL406393 8150 81 None 144 2 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
DB03619 8150 81 None 144 2 Human 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
118694559 7918 0 None -1 2 Mouse 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 470 7 0 6 4.3 COC1=C(C=CC=C1)COC(=O)C=2[C@@H](CC(N(C2C)C[C@@H]3OCCC3)=O)C=4C=NC(=CC4)Cl 37639383
12906 7918 0 None -1 2 Mouse 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 470 7 0 6 4.3 COC1=C(C=CC=C1)COC(=O)C=2[C@@H](CC(N(C2C)C[C@@H]3OCCC3)=O)C=4C=NC(=CC4)Cl 37639383
118694559 7918 0 None 1 2 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 470 7 0 6 4.3 COC1=C(C=CC=C1)COC(=O)C=2[C@@H](CC(N(C2C)C[C@@H]3OCCC3)=O)C=4C=NC(=CC4)Cl 37639383
12906 7918 0 None 1 2 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 470 7 0 6 4.3 COC1=C(C=CC=C1)COC(=O)C=2[C@@H](CC(N(C2C)C[C@@H]3OCCC3)=O)C=4C=NC(=CC4)Cl 37639383
221493 7708 87 None 2 2 Human 5.0 pEC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
3096 7708 87 None 2 2 Human 5.0 pEC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
609 7708 87 None 2 2 Human 5.0 pEC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
CHEMBL205596 7708 87 None 2 2 Human 5.0 pEC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
DB02659 7708 87 None 2 2 Human 5.0 pEC50 None 5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
10133 7697 78 None -1 4 Human 5.4 pEC50 None 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
145714624 7697 78 None -1 4 Human 5.4 pEC50 None 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
4361 7697 78 None -1 4 Human 5.4 pEC50 None 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
608 7697 78 None -1 4 Human 5.4 pEC50 None 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
CHEMBL240597 7697 78 None -1 4 Human 5.4 pEC50 None 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
DB06777 7697 78 None -1 4 Human 5.4 pEC50 None 5.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 12419312
611 9107 75 None 50 2 Human 7.5 pEC50 None 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
9903 9107 75 None 50 2 Human 7.5 pEC50 None 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
CHEMBL1478 9107 75 None 50 2 Human 7.5 pEC50 None 7.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 12419312
5755 27592 76 None - 1 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha releaseAgonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha release
Drug Central 360 2 3 5 1.6 C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO None
CHEMBL131 27592 76 None - 1 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha releaseAgonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha release
Drug Central 360 2 3 5 1.6 C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO None
93055 224501 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Agonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha releaseAgonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha release
Drug Central 458 4 2 6 3.5 CC(C)(C)CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]12C None




Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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DOI

89501446 146180 1 None - 0 Human 10.2 pEC50 = 10.2 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 8 6.7 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3793436 146180 1 None - 0 Human 10.2 pEC50 = 10.2 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 8 6.7 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
89501446 146180 1 None - 0 Mouse 10.2 pEC50 = 10.2 Binding
Agonist activity at mouse TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 8 6.7 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3793436 146180 1 None - 0 Mouse 10.2 pEC50 = 10.2 Binding
Agonist activity at mouse TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at mouse TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 8 6.7 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL5270816 200432 0 None - 0 Human 9.4 pEC50 = 9.4 Binding
Agonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP productionAgonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP production
ChEMBL 460 4 0 6 5.6 Cc1noc2cc(Cl)c(Oc3ccncc3C(=O)N3CCN(C4CC4)c4ccccc43)cc12 10.1021/acs.jmedchem.5b00342
CHEMBL5286836 201402 0 None - 0 Mouse 9.2 pEC50 = 9.2 Binding
Inhibition of mouse TGR5Inhibition of mouse TGR5
ChEMBL 615 10 0 5 6.6 CN(CC[N+](C)(C)C)C(=O)CCc1cc(Cl)c(Oc2ccsc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acsmedchemlett.3c00001
CHEMBL5315434 201402 0 None - 0 Mouse 9.2 pEC50 = 9.2 Binding
Inhibition of mouse TGR5Inhibition of mouse TGR5
ChEMBL 615 10 0 5 6.6 CN(CC[N+](C)(C)C)C(=O)CCc1cc(Cl)c(Oc2ccsc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acsmedchemlett.3c00001
CHEMBL5290871 201295 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionAgonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP production
ChEMBL 476 7 2 4 5.9 Cc1cc(/C(C[C@H](c2ccc(C3C[C@@H]4C(C(=O)O)[C@@H]4C3)cc2)c2ccc(F)cc2F)=N\O)ccn1 10.1021/acs.jmedchem.5b00342
CHEMBL5284434 201034 0 None - 0 Human 8.9 pEC50 = 8.9 Binding
Agonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assayAgonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assay
ChEMBL 587 5 0 5 8.2 Fc1cccc(F)c1-c1ccncc1CN1C(c2ccco2)=NO[C@@H]1c1cc(C(F)(F)F)cc(C(F)(F)F)c1Cl 10.1021/acs.jmedchem.5b00342
89501666 146264 0 None - 0 Human 8.8 pEC50 = 8.8 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 572 11 0 8 7.0 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4C)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3794442 146264 0 None - 0 Human 8.8 pEC50 = 8.8 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 572 11 0 8 7.0 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4C)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
46195848 89786 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at GPBAR1 in human NCI-H716 cellsAgonist activity at GPBAR1 in human NCI-H716 cells
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.5b01875
CHEMBL2181246 89786 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at GPBAR1 in human NCI-H716 cellsAgonist activity at GPBAR1 in human NCI-H716 cells
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.5b01875
46195848 89786 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at TGR5 (unknown origin)Agonist activity at TGR5 (unknown origin)
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1016/j.ejmech.2013.07.050
CHEMBL2181246 89786 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at TGR5 (unknown origin)Agonist activity at TGR5 (unknown origin)
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1016/j.ejmech.2013.07.050
46195848 89786 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.5b00342
CHEMBL2181246 89786 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.5b00342
136239453 98388 0 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407946 98388 0 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)cc1 10.1016/j.bmcl.2013.06.017
447715 203706 68 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml400247k
CHEMBL566315 203706 68 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 420 5 3 3 5.1 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)O)[C@@H]2[C@@H]1O 10.1021/ml400247k
1520267 174541 45 None - 0 Human 6.0 pEC50 = 6 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 500 8 0 8 1.8 COc1ccc(S(=O)(=O)N2CCCN(S(=O)(=O)c3ccc(OC)c(OC)c3)CC2)cc1OC 10.1021/acs.jmedchem.5b00342
CHEMBL4303545 174541 45 None - 0 Human 6.0 pEC50 = 6 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 500 8 0 8 1.8 COc1ccc(S(=O)(=O)N2CCCN(S(=O)(=O)c3ccc(OC)c(OC)c3)CC2)cc1OC 10.1021/acs.jmedchem.5b00342
10133 7697 78 None - 1 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
145714624 7697 78 None - 1 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
4361 7697 78 None - 1 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
608 7697 78 None - 1 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
CHEMBL240597 7697 78 None - 1 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
DB06777 7697 78 None - 1 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 392 4 3 3 4.5 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
136166852 98409 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2408107 98409 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136239453 98388 0 None - 0 Mouse 6.0 pEC50 = 6.0 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407946 98388 0 None - 0 Mouse 6.0 pEC50 = 6.0 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)cc1 10.1016/j.bmcl.2013.06.017
136166933 98390 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 394 5 1 3 5.6 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407949 98390 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 394 5 1 3 5.6 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
136166936 98379 0 None - 0 Mouse 6.9 pEC50 = 6.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407931 98379 0 None - 0 Mouse 6.9 pEC50 = 6.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
56602333 98382 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407934 98382 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
76328184 110995 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 391 4 3 3 4.6 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCN)[C@@H]2[C@@H]1O 10.1021/ml400247k
CHEMBL3098607 110995 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 391 4 3 3 4.6 CC[C@@H]1[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCN)[C@@H]2[C@@H]1O 10.1021/ml400247k
CHEMBL5286949 201144 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 455 4 0 5 5.0 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCN(C2COC2)c2ccccc21 10.1021/acs.jmedchem.5b00342
136166852 98409 0 None - 0 Mouse 6.9 pEC50 = 6.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2408107 98409 0 None - 0 Mouse 6.9 pEC50 = 6.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
58043414 98392 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 424 5 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407951 98392 0 None - 0 Mouse 5.9 pEC50 = 5.9 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 424 5 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL5276894 200695 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assayAgonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assay
ChEMBL 535 5 0 5 7.4 Fc1ccccc1-c1ccncc1CN1C(c2ccco2)=NOC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b00342
136166955 98387 0 None - 0 Mouse 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 10.1016/j.bmcl.2013.06.017
CHEMBL2407945 98387 0 None - 0 Mouse 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 10.1016/j.bmcl.2013.06.017
89501608 146235 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 559 11 0 9 6.1 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cncn4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3794111 146235 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 559 11 0 9 6.1 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cncn4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136260512 98389 0 None - 0 Mouse 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 346 6 1 5 3.9 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccn2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407947 98389 0 None - 0 Mouse 5.8 pEC50 = 5.8 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 346 6 1 5 3.9 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccn2)cc1 10.1016/j.bmcl.2013.06.017
66739980 146243 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at TGR5 in human STC1 cells assessed as increase in GLP-1 secretionAgonist activity at TGR5 in human STC1 cells assessed as increase in GLP-1 secretion
ChEMBL 514 8 0 5 7.4 COc1ccc(C(C)(C)c2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.5b00342
CHEMBL3794175 146243 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at TGR5 in human STC1 cells assessed as increase in GLP-1 secretionAgonist activity at TGR5 in human STC1 cells assessed as increase in GLP-1 secretion
ChEMBL 514 8 0 5 7.4 COc1ccc(C(C)(C)c2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1021/acs.jmedchem.5b00342
CHEMBL5275304 200628 0 None - 0 Mouse 7.8 pEC50 = 7.8 Binding
Inhibition of mouse TGR5Inhibition of mouse TGR5
ChEMBL 1315 33 1 21 7.0 CC#CCn1c(N2CCC[C@H](NC(=O)CCOCCOCCOCCOCCOCCOCCN(C)C(=O)CCc3cc(Cl)c(Oc4ccncc4C(=O)N4CCN(C5CC5)c5ccccc54)cc3Cl)C2)nc2c1c(=O)n(Cc1nc(C)c3ccccc3n1)c(=O)n2C 10.1021/acsmedchemlett.3c00001
66739980 146243 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 514 8 0 5 7.4 COc1ccc(C(C)(C)c2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3794175 146243 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 514 8 0 5 7.4 COc1ccc(C(C)(C)c2cnc(SCc3c(F)cccc3Cl)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
45483949 10354 35 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml400247k
7048 10354 35 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml400247k
CHEMBL567640 10354 35 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 450 5 4 4 4.3 CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)[C@H](C[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)O)[C@@H](C[C@@H](C(=O)O)C)C 10.1021/ml400247k
89501521 146203 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 8 6.7 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cccn4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3793859 146203 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 558 11 0 8 6.7 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cccn4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136166950 98377 0 None - 0 Mouse 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407929 98377 0 None - 0 Mouse 6.7 pEC50 = 6.7 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
221493 7708 87 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
3096 7708 87 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
609 7708 87 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
CHEMBL205596 7708 87 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
DB02659 7708 87 None - 0 Human 4.7 pEC50 = 4.7 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 408 4 4 4 3.4 O[C@@H]1CC[C@]2([C@@H](C1)C[C@H]([C@@H]1[C@@H]2C[C@H](O)[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C 10.1021/ml400247k
90644452 118441 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 336 3 1 4 3.2 CC(=O)c1cc(C(=O)N2CCN(C3CC3)c3ccccc32)ccc1O 10.1016/j.ejmech.2014.05.031
CHEMBL3286440 118441 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 336 3 1 4 3.2 CC(=O)c1cc(C(=O)N2CCN(C3CC3)c3ccccc32)ccc1O 10.1016/j.ejmech.2014.05.031
89501429 146137 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 517 10 0 7 6.4 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3793012 146137 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 517 10 0 7 6.4 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(C#N)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136167037 98395 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407954 98395 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136166859 98384 0 None - 0 Mouse 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407936 98384 0 None - 0 Mouse 5.7 pEC50 = 5.7 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL5279619 200809 0 None - 0 Mouse 5.7 pEC50 = 5.7 Binding
Agonist activity at mouse TGR5Agonist activity at mouse TGR5
ChEMBL 398 3 0 3 5.5 O=C(c1cccnc1Oc1cccc(C(F)(F)F)c1)N1CCCc2ccccc21 10.1021/acs.jmedchem.5b00342
CHEMBL5268940 200366 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP productionAgonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP production
ChEMBL 390 4 2 2 5.8 CC(C[C@H](C)C(=O)O)[C@H]1CCC2C3CC[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@@]21C 10.1021/acs.jmedchem.5b00342
CHEMBL5286375 201121 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP productionAgonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP production
ChEMBL 403 4 0 4 5.9 Fc1ccc(-n2c(COc3cccc4cnccc34)nc3ccccc32)c(Cl)c1 10.1021/acs.jmedchem.5b00342
CHEMBL5270683 200422 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human TGR5 transfected in CHO-K1 cells assessed as increase in cAMP productionAgonist activity at human TGR5 transfected in CHO-K1 cells assessed as increase in cAMP production
ChEMBL 702 12 2 7 6.1 Cc1c(Cl)cccc1OCCCC(=O)N1CCCc2c(-c3cnn(Cc4c(F)cc(C(=O)NCCS(=O)(=O)O)cc4Cl)c3)cccc21 10.1021/acs.jmedchem.5b00342
136166936 98379 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407931 98379 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL5284578 201037 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human TGR5 transfected in CHO-K1 cells assessed as increase in cAMP productionAgonist activity at human TGR5 transfected in CHO-K1 cells assessed as increase in cAMP production
ChEMBL 584 11 2 5 5.2 Cc1c(Cl)cccc1OCCCC(=O)N1CCC(Cc2cccc(C(=O)NCCS(=O)(=O)O)c2)c2ccccc21 10.1021/acs.jmedchem.5b00342
136166966 98386 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407944 98386 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2013.06.017
46195848 89786 0 None - 0 Mouse 5.6 pEC50 = 5.6 Binding
Agonist activity at mouse TGR5Agonist activity at mouse TGR5
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.5b00342
CHEMBL2181246 89786 0 None - 0 Mouse 5.6 pEC50 = 5.6 Binding
Agonist activity at mouse TGR5Agonist activity at mouse TGR5
ChEMBL 398 3 0 3 5.8 O=C(c1cccnc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.5b00342
CHEMBL5289884 201262 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at GPBAR1 in human NCI-H716 cellsAgonist activity at GPBAR1 in human NCI-H716 cells
ChEMBL 581 6 2 6 7.1 Cc1cc(NC(=O)c2cc(Cl)c(Oc3ncccc3C(=O)N3CCCc4ccccc43)cc2Cl)sc1C(=O)O 10.1021/acs.jmedchem.5b01875
56602333 98382 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407934 98382 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
136166845 98393 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 374 6 2 4 4.8 Cc1cc(/C(CC(c2ccc(C(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407952 98393 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 374 6 2 4 4.8 Cc1cc(/C(CC(c2ccc(C(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136166900 98385 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N/O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407938 98385 0 None - 0 Human 6.6 pEC50 = 6.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N/O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
136167006 98391 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 408 5 1 3 5.9 Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407950 98391 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 408 5 1 3 5.9 Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136167004 98378 7 None - 0 Mouse 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407930 98378 7 None - 0 Mouse 7.6 pEC50 = 7.6 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL5281639 200900 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionAgonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP production
ChEMBL 428 6 1 5 3.6 Cc1ccccc1[C@H](C/C(=N/O)C1CCC(=O)N(C)C1)c1ccc(S(C)(=O)=O)cc1 10.1021/acs.jmedchem.5b00342
136166841 98396 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3cccc(C(=O)O)c3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407955 98396 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3cccc(C(=O)O)c3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
90654587 116732 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nMAgonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nM
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234568 116732 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nMAgonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nM
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
58043589 98383 0 None - 0 Mouse 5.5 pEC50 = 5.5 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407935 98383 0 None - 0 Mouse 5.5 pEC50 = 5.5 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
127029731 146262 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 575 11 0 8 7.6 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-c4nccs4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3794424 146262 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 575 11 0 8 7.6 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-c4nccs4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136166933 98390 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 394 5 1 3 5.6 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407949 98390 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 394 5 1 3 5.6 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
58043236 98381 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407933 98381 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL5281159 200885 0 None - 0 Mouse 6.5 pEC50 = 6.5 Binding
Agonist activity at mouse TGR5Agonist activity at mouse TGR5
ChEMBL 550 6 2 8 4.6 O=C(Nc1nnn[nH]1)c1cc(Cl)c(Oc2ncccc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.5b00342
17755103 205603 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at TGR5 (unknown origin)Agonist activity at TGR5 (unknown origin)
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O)C(=O)O 10.1021/acs.jmedchem.5b00342
CHEMBL583611 205603 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at TGR5 (unknown origin)Agonist activity at TGR5 (unknown origin)
ChEMBL 406 4 3 3 4.7 C[C@@H](C[C@@H](C)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O)C(=O)O 10.1021/acs.jmedchem.5b00342
136166845 98393 0 None - 0 Mouse 5.4 pEC50 = 5.4 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 374 6 2 4 4.8 Cc1cc(/C(CC(c2ccc(C(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407952 98393 0 None - 0 Mouse 5.4 pEC50 = 5.4 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 374 6 2 4 4.8 Cc1cc(/C(CC(c2ccc(C(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
89501780 146253 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 492 10 0 6 6.5 COc1ccc(C(C)(C)c2cnc(SCCOc3ccccc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3794293 146253 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 492 10 0 6 6.5 COc1ccc(C(C)(C)c2cnc(SCCOc3ccccc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136260512 98389 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 346 6 1 5 3.9 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccn2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407947 98389 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 346 6 1 5 3.9 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccn2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL5279619 200809 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 398 3 0 3 5.5 O=C(c1cccnc1Oc1cccc(C(F)(F)F)c1)N1CCCc2ccccc21 10.1021/acs.jmedchem.5b00342
136167004 98378 7 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407930 98378 7 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 457 7 2 5 5.4 Cc1cc(/C(C[C@H](c2ccc(N3CCC(C(=O)O)CC3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL5278743 200773 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at TGR5 (unknown origin) expressed in CHO cells incubated for 0.5 hr by microplate reader based analysisAgonist activity at TGR5 (unknown origin) expressed in CHO cells incubated for 0.5 hr by microplate reader based analysis
ChEMBL 529 7 0 5 6.9 COc1cc(Cl)cc(N(CC23CCC(c4ccc(OC)c(C#N)c4)(CC2)CC3)C(=O)c2ccncc2C)c1 10.1021/acs.jmedchem.1c01017
136166859 98384 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407936 98384 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 345 6 1 4 4.5 CN(C)c1ccc(C(C/C(=N\O)c2ccncc2)c2ccccc2)cc1 10.1016/j.bmcl.2013.06.017
56601732 98380 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407932 98380 0 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
90654600 116785 0 None - 0 Mouse 7.3 pEC50 = 7.3 Binding
Agonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nMAgonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nM
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234871 116785 0 None - 0 Mouse 7.3 pEC50 = 7.3 Binding
Agonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nMAgonist activity at TGR5 in mouse GLUTag cells assessed as secretion of GLP-1 after 2 hrs by HEK293 cell-based luciferase reporter gene assay in presence of DPP4 inhibitor PKF275 at 600 nM
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL5286406 201124 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at GPBAR1 in human NCI-H716 cellsAgonist activity at GPBAR1 in human NCI-H716 cells
ChEMBL 470 6 1 4 5.8 O=C(O)CCc1cc(Cl)c(Oc2ncccc2C(=O)N2CCCc3ccccc32)cc1Cl 10.1021/acs.jmedchem.5b01875
90644454 119009 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 413 5 0 5 4.7 CC(=O)c1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1016/j.ejmech.2014.05.031
CHEMBL3290739 119009 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 413 5 0 5 4.7 CC(=O)c1cccc(Oc2ccncc2C(=O)N2CCN(C3CC3)c3ccccc32)c1 10.1016/j.ejmech.2014.05.031
CHEMBL5268028 200325 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Agonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assayAgonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assay
ChEMBL 569 5 0 5 8.1 Fc1ccccc1-c1ccncc1CN1C(c2ccco2)=NOC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1Cl 10.1021/acs.jmedchem.5b00342
89501594 146176 0 None - 0 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 576 11 0 8 6.9 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3793388 146176 0 None - 0 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 576 11 0 8 6.9 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136166950 98377 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407929 98377 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(C[C@@H](c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL5272181 200492 0 None - 0 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionAgonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP production
ChEMBL 425 5 1 5 4.3 Cc1ccccc1[C@H](C/C(=N/O)c1ccc(=O)n(C)n1)c1ccc(Br)cc1 10.1021/acs.jmedchem.5b00342
56601732 98380 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407932 98380 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
136166866 98394 0 None - 0 Mouse 5.2 pEC50 = 5.2 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 388 7 2 4 4.7 Cc1cc(/C(CC(c2ccc(CC(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407953 98394 0 None - 0 Mouse 5.2 pEC50 = 5.2 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 388 7 2 4 4.7 Cc1cc(/C(CC(c2ccc(CC(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
155339364 189495 0 None - 0 Mouse 7.2 pEC50 = 7.2 Binding
Inhibition of mouse TGR5Inhibition of mouse TGR5
ChEMBL 583 11 6 8 1.9 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1021/acsmedchemlett.3c00001
CHEMBL4789628 189495 0 None - 0 Mouse 7.2 pEC50 = 7.2 Binding
Inhibition of mouse TGR5Inhibition of mouse TGR5
ChEMBL 583 11 6 8 1.9 CO[C@@H]1C[C@@H]2C[C@H](O)CC[C@]2(C)[C@H]2CC[C@@]3(C)[C@@H](CC[C@@H]3[C@H](C)CCC(=O)N(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)[C@@H]21 10.1021/acsmedchemlett.3c00001
58043236 98381 0 None - 0 Mouse 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407933 98381 0 None - 0 Mouse 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 466 7 2 5 5.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(-c2ccc(C(=O)O)cc2)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL5273781 200557 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at GPBAR1 in human NCI-H716 cellsAgonist activity at GPBAR1 in human NCI-H716 cells
ChEMBL 527 8 2 5 4.9 O=C(O)CNC(=O)CCc1cc(Cl)c(Oc2ncccc2C(=O)N2CCCc3ccccc32)cc1Cl 10.1021/acs.jmedchem.5b01875
CHEMBL5275121 200618 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at GPBAR1 in human NCI-H716 cellsAgonist activity at GPBAR1 in human NCI-H716 cells
ChEMBL 485 6 2 5 4.5 O=C(NCCO)c1cc(Cl)c(Oc2ncccc2C(=O)N2CCCc3ccccc32)cc1Cl 10.1021/acs.jmedchem.5b01875
CHEMBL5283173 200968 0 None - 0 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at TGR5 in human T-lymphocyte cells assessed as increase in cAMP productionAgonist activity at TGR5 in human T-lymphocyte cells assessed as increase in cAMP production
ChEMBL 603 7 0 5 6.7 CS(=O)(=O)c1ccc(CC2CCC(c3c(C(=O)N4CCC(c5ccc(F)cc5)C4)cnn3-c3ccc(F)cc3)CC2)cc1 10.1021/acs.jmedchem.5b00342
CHEMBL5280567 200854 0 None - 0 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionAgonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP production
ChEMBL 398 3 0 3 5.8 O=C(c1ccncc1Oc1cc(Cl)ccc1Cl)N1CCCc2ccccc21 10.1021/acs.jmedchem.5b00342
89501494 146130 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 557 11 0 7 7.3 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cccc4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3792957 146130 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 557 11 0 7 7.3 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4cccc4)cc3)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
136166866 98394 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 388 7 2 4 4.7 Cc1cc(/C(CC(c2ccc(CC(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407953 98394 0 None - 0 Human 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 388 7 2 4 4.7 Cc1cc(/C(CC(c2ccc(CC(=O)O)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
136166966 98386 0 None - 0 Mouse 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407944 98386 0 None - 0 Mouse 6.2 pEC50 = 6.2 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccncc1)c1ccc(N(C)C)cc1 10.1016/j.bmcl.2013.06.017
611 9107 75 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/ml400247k
9903 9107 75 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/ml400247k
CHEMBL1478 9107 75 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at wild type TGR5 (unknown origin)Agonist activity at wild type TGR5 (unknown origin)
ChEMBL 376 4 2 2 5.5 O[C@@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)C 10.1021/ml400247k
CHEMBL5280905 200868 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Agonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP productionAgonist activity at TGR5 in human HEK293 cells assessed as increase in cAMP production
ChEMBL 449 5 0 4 5.8 N#Cc1cc(F)ccc1N(C(=O)COc1cccc2cnccc12)c1ccc(F)cc1Cl 10.1021/acs.jmedchem.5b00342
136167006 98391 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 408 5 1 3 5.9 Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407950 98391 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 408 5 1 3 5.9 Cc1cc(/C(CC(c2ccc(Br)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL5267358 200303 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionAgonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP production
ChEMBL 483 5 0 6 4.0 COc1cc(F)ccc1-c1ccnnc1N(C)C(=O)c1cc(C(F)(F)F)cc(S(C)(=O)=O)c1 10.1021/acs.jmedchem.5b00342
CHEMBL5281159 200885 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human TGR5Agonist activity at human TGR5
ChEMBL 550 6 2 8 4.6 O=C(Nc1nnn[nH]1)c1cc(Cl)c(Oc2ncccc2C(=O)N2CCN(C3CC3)c3ccccc32)cc1Cl 10.1021/acs.jmedchem.5b00342
CHEMBL5274626 200602 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assayAgonist activity at human TGR5 expressed in human HEK293 cells measured after 5.5 hrs by steady-glo luciferase assay
ChEMBL 545 5 0 4 7.8 Fc1ccccc1-c1ccncc1CN1C(c2ccccc2)=NOC1c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/acs.jmedchem.5b00342
136166955 98387 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 10.1016/j.bmcl.2013.06.017
CHEMBL2407945 98387 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 359 6 1 4 4.9 Cc1cccc(C(C/C(=N\O)c2ccncc2)c2ccc(N(C)C)cc2)c1 10.1016/j.bmcl.2013.06.017
58043414 98392 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 424 5 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407951 98392 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 424 5 1 4 4.9 Cc1ccccc1C(C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(Br)cc1 10.1016/j.bmcl.2013.06.017
89501844 146158 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 590 11 0 8 7.2 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
CHEMBL3793168 146158 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assayAgonist activity at human TGR5 expressed in CHO-K1 cells after 5 hrs by luciferase reporter gene assay
ChEMBL 590 11 0 8 7.2 COc1ccc(C(C)(C)c2cnc(SCCOc3ccc(-n4ccnc4C)cc3F)n2-c2ccc(F)cc2)cc1OC 10.1021/acsmedchemlett.5b00323
58043589 98383 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
CHEMBL2407935 98383 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at recombinant human GPBAR1 expressed in CHO cellsAgonist activity at recombinant human GPBAR1 expressed in CHO cells
ChEMBL 424 6 1 6 3.5 Cc1ccccc1[C@@H](C/C(=N\O)c1ccc(=O)n(C)c1)c1ccc(S(C)(=O)=O)cc1 10.1016/j.bmcl.2013.06.017
136166841 98396 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3cccc(C(=O)O)c3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407955 98396 0 None - 0 Mouse 6.1 pEC50 = 6.1 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3cccc(C(=O)O)c3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL5286933 201142 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionAgonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP production
ChEMBL 565 6 0 6 4.2 COc1cc(F)ccc1-c1ccncc1N(C)C(=O)c1cc(C(F)(F)F)cc(S(=O)(=O)N2CC3(COC3)C2)c1 10.1021/acs.jmedchem.5b00342
CHEMBL5272787 200515 0 None - 0 Human 7.1 pEC50 = 7.1 Binding
Agonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP productionAgonist activity at human TGR5 transfected in CHO cells assessed as increase in cAMP production
ChEMBL 380 3 0 4 4.5 CN(C(=O)c1c(-c2ccc(F)cc2)nc2ncccn12)c1ccc(Cl)cc1 10.1021/acs.jmedchem.5b00342
136167037 98395 0 None - 0 Mouse 7.0 pEC50 = 7.0 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
CHEMBL2407954 98395 0 None - 0 Mouse 7.0 pEC50 = 7.0 Binding
Agonist activity at recombinant mouse GPBAR1 expressed in CHO cellsAgonist activity at recombinant mouse GPBAR1 expressed in CHO cells
ChEMBL 450 7 2 4 6.5 Cc1cc(/C(CC(c2ccc(-c3ccc(C(=O)O)cc3)cc2)c2ccccc2C)=N/O)ccn1 10.1016/j.bmcl.2013.06.017
90654600 116785 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assayAgonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assay
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
CHEMBL3234871 116785 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Agonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assayAgonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assay
ChEMBL 577 8 2 6 5.3 N#Cc1ccc(CCNC(=O)[C@@H]2CCN2c2cc(-c3ccc([C@H]4CC[C@H](C(=O)O)CC4)cc3)nc(C(F)(F)F)n2)cc1 10.1021/jm401731q
5755 27592 76 None - 0 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha releaseAgonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha release
ChEMBL 360 2 3 5 1.6 C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO 10.1021/acsmedchemlett.5b00323
CHEMBL131 27592 76 None - 0 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha releaseAgonist activity at TGR5 in human whole blood assessed as inhibition of LPS-induced TNF-alpha release
ChEMBL 360 2 3 5 1.6 C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO 10.1021/acsmedchemlett.5b00323
90654587 116732 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assayAgonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q
CHEMBL3234568 116732 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assayAgonist activity at TGR5 in human PBMC assessed as inhibition of LPS-induced TNFalpha production preincubated for 30 mins followed by LPS stimulation measured after 3 hrs by HTRF assay
ChEMBL 501 6 1 7 2.7 CN1CCN(c2cc(N3CCC[C@@H](C(=O)NCCc4ccc(C#N)cc4)C3)nc(C(F)(F)F)n2)CC1 10.1021/jm401731q