Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	122653602	184827	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	8	2	6	3.7	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NC5CCN(CCO)CC5)cccc43)c2)cc1F	nan
	CHEMBL4852000	184827	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	8	2	6	3.7	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NC5CCN(CCO)CC5)cccc43)c2)cc1F	nan
	122653721	184398	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	CHEMBL4845846	184398	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	122653713	184433	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4846330	184433	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1	nan
	122653650	184434	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1cc(Cl)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4846333	184434	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1cc(Cl)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653704	184438	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	409	6	2	4	3.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	CHEMBL4846416	184438	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	409	6	2	4	3.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	122653665	184452	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	510	7	2	5	4.0	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4846586	184452	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	510	7	2	5	4.0	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653719	184462	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccnc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4846775	184462	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccnc(C(F)(F)F)c2)ccn1	nan
	122653649	184468	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cccc(Cc2cccc(C(F)(F)F)c2)n1	nan
	CHEMBL4846914	184468	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cccc(Cc2cccc(C(F)(F)F)c2)n1	nan
	122653642	184476	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4846977	184476	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653806	184521	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	486	7	1	4	4.8	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4847685	184521	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	486	7	1	4	4.8	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653408	184523	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	475	7	3	5	3.0	O=C(NC[C@@H](O)CO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4847708	184523	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	475	7	3	5	3.0	O=C(NC[C@@H](O)CO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653470	184527	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NC[C@@H](O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4847735	184527	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NC[C@@H](O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653679	184560	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	5	2.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(Cl)nc2)ccn1	nan
	CHEMBL4848378	184560	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	5	2.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(Cl)nc2)ccn1	nan
	122653688	184561	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4848379	184561	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653654	184580	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	436	5	1	4	4.6	N#CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4848606	184580	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	436	5	1	4	4.6	N#CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653571	184589	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	CHEMBL4848812	184589	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	122653464	184612	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	2	4	4.2	O=C(NCC(O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4849056	184612	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	2	4	4.2	O=C(NCC(O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653683	184625	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	465	9	2	6	3.3	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(OC)c(F)c2)ccn1	nan
	CHEMBL4849398	184625	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	465	9	2	6	3.3	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(OC)c(F)c2)ccn1	nan
	122653417	184650	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4849645	184650	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653491	184655	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	368	4	2	3	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc3[nH]ccc23)ccn1	nan
	CHEMBL4849698	184655	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	368	4	2	3	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc3[nH]ccc23)ccn1	nan
	122653696	184674	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	5	1	4	4.5	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1C(F)(F)F	nan
	CHEMBL4849904	184674	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	5	1	4	4.5	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1C(F)(F)F	nan
	122653579	184679	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4849970	184679	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653601	184688	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(C(F)(F)F)c2)ccn1	nan
	CHEMBL4850054	184688	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(C(F)(F)F)c2)ccn1	nan
	122653613	184726	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	6	2	4	4.4	Cc1c(Cc2cccc(C(F)(F)F)c2)ccnc1N1CCc2c(C(=O)NCCO)cccc21	nan
	CHEMBL4850541	184726	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	6	2	4	4.4	Cc1c(Cc2cccc(C(F)(F)F)c2)ccnc1N1CCc2c(C(=O)NCCO)cccc21	nan
	122653676	184745	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4850812	184745	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cncc(C(F)(F)F)c2)ccn1	nan
	122653686	184756	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	6	2	4	3.5	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4850965	184756	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	6	2	4	3.5	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653731	184763	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	460	6	2	5	3.1	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)N[C@H]5CCNC5=O)cccc43)c2)cc1F	nan
	CHEMBL4851069	184763	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	460	6	2	5	3.1	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)N[C@H]5CCNC5=O)cccc43)c2)cc1F	nan
	122653592	184782	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	379	4	1	3	4.0	CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	CHEMBL4851368	184782	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	379	4	1	3	4.0	CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	122653436	184783	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	9	2	5	3.5	O=C(NCCOCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4851394	184783	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	9	2	5	3.5	O=C(NCCOCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653690	184789	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	369	4	1	4	4.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4851533	184789	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	369	4	1	4	4.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653558	184790	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4851577	184790	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653573	184809	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	394	5	1	5	3.5	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1Cl	nan
	CHEMBL4851800	184809	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	394	5	1	5	3.5	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1Cl	nan
	122653608	184819	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	7	2	5	3.3	CC(=O)c1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ccn2)c1	nan
	CHEMBL4851936	184819	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	7	2	5	3.3	CC(=O)c1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ccn2)c1	nan
	122653448	184841	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(Cl)c2)ccn1	nan
	CHEMBL4852273	184841	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(Cl)c2)ccn1	nan
	122653452	184847	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	4	1	4	3.4	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	CHEMBL4852339	184847	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	4	1	4	3.4	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	122653453	184854	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@H](O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4852404	184854	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@H](O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653427	184880	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	373	4	1	5	3.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)OCO3)ccn1	nan
	CHEMBL4852734	184880	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	373	4	1	5	3.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)OCO3)ccn1	nan
	122653420	184905	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	5	3.8	O=C(N[C@H]1CCOC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4853193	184905	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	5	3.8	O=C(N[C@H]1CCOC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122654155	184923	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	429	6	1	3	4.5	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4853351	184923	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	429	6	1	3	4.5	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653581	184936	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4853555	184936	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653658	184937	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	483	7	2	5	3.5	O=C(NCC1(CO)COC1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4853557	184937	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	483	7	2	5	3.5	O=C(NCC1(CO)COC1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653641	184945	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	348	4	1	5	3.1	Cc1noc(C)c1Cc1ccnc(N2CCc3c(C(N)=O)cccc32)c1	nan
	CHEMBL4853689	184945	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	348	4	1	5	3.1	Cc1noc(C)c1Cc1ccnc(N2CCc3c(C(N)=O)cccc32)c1	nan
	122653547	184955	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	391	6	1	4	4.0	CCOc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4853824	184955	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	391	6	1	4	4.0	CCOc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653619	184962	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	429	6	1	3	4.5	O=C(NCCF)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4853939	184962	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	429	6	1	3	4.5	O=C(NCCF)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653645	184974	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4854092	184974	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653725	184976	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4854146	184976	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653537	184979	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	494	5	1	4	5.2	CN1CCC(NC(=O)c2cccc3c2CCN3c2cc(Cc3cccc(C(F)(F)F)c3)ccn2)CC1	nan
	CHEMBL4854218	184979	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	494	5	1	4	5.2	CN1CCC(NC(=O)c2cccc3c2CCN3c2cc(Cc3cccc(C(F)(F)F)c3)ccn2)CC1	nan
	122653488	185006	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@H](O)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4854701	185006	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@H](O)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653599	185012	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	319	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccoc2)ccn1	nan
	CHEMBL4854849	185012	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	319	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccoc2)ccn1	nan
	122653722	185028	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4855055	185028	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653455	185032	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NCC(O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4855110	185032	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NCC(O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653627	185042	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	452	7	1	4	4.5	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4855290	185042	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	452	7	1	4	4.5	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653632	185058	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	494	7	1	4	4.1	O=C(NCCN1CCCC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4855414	185058	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	494	7	1	4	4.1	O=C(NCCN1CCCC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653486	185069	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4855646	185069	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653810	185079	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	4	1	3	5.1	CNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)cc(C)n1	nan
	CHEMBL4855829	185079	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	4	1	3	5.1	CNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)cc(C)n1	nan
	122653618	185089	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	6	1	4	4.8	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4856011	185089	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	6	1	4	4.8	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	164609725	185097	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	447	7	1	4	5.2	O=C(NCC(F)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4856051	185097	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	447	7	1	4	5.2	O=C(NCC(F)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	164609750	185123	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	536	8	2	5	4.7	O=C(NCC(O)Cc1cccnc1)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4856315	185123	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	536	8	2	5	4.7	O=C(NCC(O)Cc1cccnc1)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	164614108	185131	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	8	1	5	4.8	COC[C@@H](F)CNC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4856557	185131	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	8	1	5	4.8	COC[C@@H](F)CNC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	164614116	185136	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	524	8	1	5	4.8	O=C(NCCCN1CCOCC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4856676	185136	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	524	8	1	5	4.8	O=C(NCCCN1CCOCC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653723	185143	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	359	5	1	4	3.5	COc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4856786	185143	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	359	5	1	4	3.5	COc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653607	185148	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4856937	185148	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653609	185231	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4858042	185231	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653629	185232	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	361	5	1	6	2.3	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	CHEMBL4858047	185232	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	361	5	1	6	2.3	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	122653504	185238	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	483	5	1	4	4.1	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)c[n+]([O-])c1	nan
	CHEMBL4858187	185238	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	483	5	1	4	4.1	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)c[n+]([O-])c1	nan
	122653540	185245	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4858311	185245	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653412	185254	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	7	2	4	4.5	O=C(NCCc1cnc[nH]1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4858448	185254	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	7	2	4	4.5	O=C(NCCc1cnc[nH]1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653473	185262	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	486	7	2	4	3.8	CC(=O)NCCNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4858574	185262	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	486	7	2	4	3.8	CC(=O)NCCNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653489	185326	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	378	5	1	5	3.0	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4859593	185326	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	378	5	1	5	3.0	COc1ncc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653708	185346	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	383	4	1	3	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4860064	185346	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	383	4	1	3	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653667	185359	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	6	2	5	3.8	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4860274	185359	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	6	2	5	3.8	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653407	185362	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4860294	185362	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653481	185415	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	516	8	2	6	3.9	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(=O)NC5CCN(CCO)CC5)cccc43)c2)ccc1F	nan
	CHEMBL4861199	185415	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	516	8	2	6	3.9	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(=O)NC5CCN(CCO)CC5)cccc43)c2)ccc1F	nan
	122653808	185434	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	498	7	2	6	3.5	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	CHEMBL4861454	185434	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	498	7	2	6	3.5	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	122653426	185463	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	480	5	2	4	3.8	O=C1CCC(NC(=O)c2cccc3c2CCN3c2cc(Cc3cc(F)c(F)c(F)c3)ccn2)CN1	nan
	CHEMBL4861879	185463	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	480	5	2	4	3.8	O=C1CCC(NC(=O)c2cccc3c2CCN3c2cc(Cc3cc(F)c(F)c(F)c3)ccn2)CN1	nan
	122653405	185469	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4861950	185469	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653749	185506	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	475	7	3	5	3.0	O=C(NC(CO)CO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4862500	185506	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	475	7	3	5	3.0	O=C(NC(CO)CO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653745	185511	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	8	2	6	3.3	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCC5(CO)COC5)cccc43)c2)cc1F	nan
	CHEMBL4862529	185511	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	8	2	6	3.3	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCC5(CO)COC5)cccc43)c2)cc1F	nan
	122653500	185548	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	8	2	5	3.7	COC[C@@H](O)CNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4863091	185548	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	8	2	5	3.7	COC[C@@H](O)CNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653416	185553	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	7	2	4	4.5	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4863198	185553	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	7	2	4	4.5	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653669	185573	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	417	4	1	4	4.8	NC(=O)c1cccc2c1CCN2c1cc(Oc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4863386	185573	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	417	4	1	4	4.8	NC(=O)c1cccc2c1CCN2c1cc(Oc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653624	185578	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	364	4	1	4	3.5	NC(=O)c1cccc2c1CCN2c1cc(Cc2cncc(Cl)c2)ccn1	nan
	CHEMBL4863447	185578	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	364	4	1	4	3.5	NC(=O)c1cccc2c1CCN2c1cc(Cc2cncc(Cl)c2)ccn1	nan
	122653435	185584	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	439	7	2	5	3.4	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCO)c2)cc1F	nan
	CHEMBL4863562	185584	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	439	7	2	5	3.4	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCO)c2)cc1F	nan
	122653567	185585	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4863576	185585	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC[C@@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653804	185587	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	464	5	2	4	3.8	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4863613	185587	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	464	5	2	4	3.8	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653543	185592	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	452	5	2	5	3.7	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4863658	185592	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	452	5	2	5	3.7	O=C(N[C@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653554	185605	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	9	2	6	3.9	O=C(NCCOCCO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4863892	185605	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	9	2	6	3.9	O=C(NCCOCCO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653694	185615	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4864049	185615	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653480	185637	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4864397	185637	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653747	185643	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)n2)ccn1	nan
	CHEMBL4864476	185643	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)n2)ccn1	nan
	122653506	185670	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4864933	185670	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	3	5	2.9	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653610	185677	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4865057	185677	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653750	185682	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1Cl	nan
	CHEMBL4865124	185682	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1Cl	nan
	122653520	185683	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	508	7	2	5	4.3	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4865128	185683	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	508	7	2	5	4.3	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653728	185712	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4865653	185712	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.5	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653434	185723	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4865786	185723	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653569	185728	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2ccc(F)c(C(F)(F)F)c2)c1	nan
	CHEMBL4865910	185728	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	4	4.2	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2ccc(F)c(C(F)(F)F)c2)c1	nan
	122653712	185733	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(Cl)c(F)c2)ccn1	nan
	CHEMBL4865996	185733	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	381	4	1	3	4.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(Cl)c(F)c2)ccn1	nan
	122653803	185743	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4866193	185743	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	122653465	185765	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	319	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccco2)ccn1	nan
	CHEMBL4866434	185765	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	319	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccco2)ccn1	nan
	122653620	185768	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	6	2	4	4.5	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4866463	185768	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	455	6	2	4	4.5	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653724	185775	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@@H](O)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4866543	185775	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@@H](O)CF)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653706	185782	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	2	4	4.2	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4866626	185782	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	457	7	2	4	4.2	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122660774	185789	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2cc(N3CCc4c(C(=O)NC[C@@H](O)CF)cccc43)ccn2)cc1F	nan
	CHEMBL4866746	185789	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2cc(N3CCc4c(C(=O)NC[C@@H](O)CF)cccc43)ccn2)cc1F	nan
	122653748	185796	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.3	C[C@H](O)[C@@H](CO)NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4866874	185796	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	7	3	5	3.3	C[C@H](O)[C@@H](CO)NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653717	185810	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)n2)ccn1	nan
	CHEMBL4867044	185810	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)n2)ccn1	nan
	122653680	185849	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	524	7	2	5	4.6	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4867659	185849	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	524	7	2	5	4.6	O=C(NC1CCN(CCO)CC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653626	185850	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COCC(O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4867681	185850	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COCC(O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653477	185878	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1cc(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4868214	185878	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1cc(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653697	185896	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	373	5	1	4	3.8	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1C	nan
	CHEMBL4868562	185896	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	373	5	1	4	3.8	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1C	nan
	122653462	185901	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4868643	185901	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653545	185909	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	380	4	1	4	4.0	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc3ncccc23)ccn1	nan
	CHEMBL4868799	185909	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	380	4	1	4	4.0	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc3ncccc23)ccn1	nan
	122653419	185917	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	7	1	4	4.4	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCF)c2)cc1F	nan
	CHEMBL4868949	185917	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	7	1	4	4.4	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCF)c2)cc1F	nan
	122653460	185918	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	6	2	5	3.0	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	CHEMBL4869015	185918	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	6	2	5	3.0	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)CCO3)ccn1	nan
	122653519	185921	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4869072	185921	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653693	185926	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	7	2	4	3.9	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4869130	185926	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	7	2	4	3.9	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653518	185927	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4869139	185927	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653692	185936	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	389	5	1	4	3.8	CC(=O)c1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4869262	185936	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	389	5	1	4	3.8	CC(=O)c1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653691	185938	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	5	2	4	3.5	O=C(N[C@@H]1CCNC1=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4869305	185938	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	5	2	4	3.5	O=C(N[C@@H]1CCNC1=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653630	185949	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	8	2	5	3.7	COC[C@H](O)CNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4869524	185949	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	8	2	5	3.7	COC[C@H](O)CNC(=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653483	185982	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4869851	185982	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653648	185986	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	395	5	1	4	3.8	COc1c(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4870024	185986	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	395	5	1	4	3.8	COc1c(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	122653406	185987	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	2	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(CO)c(F)c2)ccn1	nan
	CHEMBL4870029	185987	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	2	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(CO)c(F)c2)ccn1	nan
	122653709	186040	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	355	4	1	5	2.7	N#Cc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	CHEMBL4870751	186040	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	355	4	1	5	2.7	N#Cc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	122653458	186047	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4870894	186047	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](O)CF)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653638	186049	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	2	4	3.7	CC(=O)NCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4870900	186049	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	2	4	3.7	CC(=O)NCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653428	186060	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	5	4.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4871052	186060	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	6	2	5	4.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ccn1	nan
	122653751	186074	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(F)c2)ccn1	nan
	CHEMBL4871344	186074	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	365	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(F)c2)ccn1	nan
	122653586	186132	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	7	1	5	4.4	O=C(NCCn1ccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4871971	186132	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	477	7	1	5	4.4	O=C(NCCn1ccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653589	186138	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(Cl)c2)ccn1	nan
	CHEMBL4872112	186138	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(Cl)c2)ccn1	nan
	122653461	186144	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4872227	186144	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	397	4	1	3	4.5	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653597	186154	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	542	7	2	5	4.7	O=C(NC1CCN(CCO)CC1)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4872358	186154	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	542	7	2	5	4.7	O=C(NC1CCN(CCO)CC1)c1c(F)ccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122660773	186258	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2cc(N3CCc4c(C(=O)NC[C@H](O)CF)cccc43)ccn2)cc1F	nan
	CHEMBL4873801	186258	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2cc(N3CCc4c(C(=O)NC[C@H](O)CF)cccc43)ccn2)cc1F	nan
	122653482	186259	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4873808	186259	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653628	186274	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4874029	186274	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653590	186313	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4874627	186313	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	466	5	2	4	3.4	O=C(N[C@@H]1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653603	186349	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	458	5	1	4	5.8	O=C(Nc1ccncc1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4875102	186349	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	458	5	1	4	5.8	O=C(Nc1ccncc1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	122653521	186352	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1ccccn1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4875163	186352	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1ccccn1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	164629075	186360	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	508	8	1	4	5.6	O=C(NCCCN1CCCC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4875342	186360	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	508	8	1	4	5.6	O=C(NCCCN1CCCC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653698	186366	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	435	5	1	4	4.2	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	CHEMBL4875443	186366	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	435	5	1	4	4.2	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ccn1	nan
	122653514	186379	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	5	2	4	3.5	O=C(N[C@H]1CCNC1=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4875637	186379	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	5	2	4	3.5	O=C(N[C@H]1CCNC1=O)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122654150	186414	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	363	4	2	4	3.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(O)c2)ccn1	nan
	CHEMBL4876057	186414	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	363	4	2	4	3.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(O)c2)ccn1	nan
	122653705	186417	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	360	5	1	5	2.9	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	CHEMBL4876095	186417	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	360	5	1	5	2.9	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cn1	nan
	122653595	186431	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	382	4	1	4	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(F)c(Cl)c2)ccn1	nan
	CHEMBL4876282	186431	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	382	4	1	4	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(F)c(Cl)c2)ccn1	nan
	122653585	186448	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	1	4	4.7	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4876504	186448	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	1	4	4.7	CN(C)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653634	186476	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@H](F)CO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	CHEMBL4876839	186476	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	7	2	5	4.2	O=C(NC[C@H](F)CO)c1cccc2c1CCN2c1cc(Cc2ccc3occc3c2)ccn1	nan
	122653720	186498	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	421	7	2	5	3.2	COc1cc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)ccc1F	nan
	CHEMBL4877278	186498	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	421	7	2	5	3.2	COc1cc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)ccc1F	nan
	122653695	186499	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1ccncc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4877331	186499	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1ccncc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653677	186509	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(C(F)(F)F)c2)ccn1	nan
	CHEMBL4877494	186509	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	3	4.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(C(F)(F)F)c2)ccn1	nan
	122653672	186512	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1Cl	nan
	CHEMBL4877524	186512	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	393	5	1	4	4.1	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1Cl	nan
	122653640	186529	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1cc(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4877713	186529	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1cc(F)cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653538	186541	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)n1	nan
	CHEMBL4877909	186541	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	398	4	1	4	3.9	NC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)n1	nan
	122653534	186557	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)c[n+]([O-])c1	nan
	CHEMBL4878069	186557	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	4	1	3	3.7	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)c[n+]([O-])c1	nan
	122653451	186560	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4878142	186560	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NCC(O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653510	186566	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	389	5	1	4	3.8	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	CHEMBL4878221	186566	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	389	5	1	4	3.8	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	122653549	186586	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NC[C@@H](F)CO)cccc43)c2)cc1F	nan
	CHEMBL4878529	186586	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	453	8	2	5	3.6	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NC[C@@H](F)CO)cccc43)c2)cc1F	nan
	122653729	186595	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4878629	186595	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	3.9	C[C@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653583	186622	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NCC(O)CF)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4879330	186622	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NCC(O)CF)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	122653714	185902	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4868685	185902	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1ccnc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653423	185540	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	433	7	2	5	3.4	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)ccc1F	nan
	CHEMBL4862971	185540	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	433	7	2	5	3.4	CC(=O)c1cc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)ccc1F	nan
	122653512	186151	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	480	8	2	5	3.5	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCNC(C)=O)c2)cc1F	nan
	CHEMBL4872333	186151	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	480	8	2	5	3.5	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NCCNC(C)=O)c2)cc1F	nan
	162676039	183463	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	456	6	2	6	3.1	O=C(c1cccc(C(F)(F)F)c1)c1cc(N2CCc3c(C(=O)NCCO)cccc32)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4799062	183463	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	456	6	2	6	3.1	O=C(c1cccc(C(F)(F)F)c1)c1cc(N2CCc3c(C(=O)NCCO)cccc32)ncn1	10.1021/acs.jmedchem.0c01498
	162662654	181893	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4779158	181893	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	122653659	184546	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cccc(Cc2cccc(C(F)(F)F)c2)n1	nan
	CHEMBL4848041	184546	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cccc(Cc2cccc(C(F)(F)F)c2)n1	nan
	162659079	181283	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	392	6	2	5	2.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4762205	181283	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	392	6	2	5	2.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162663893	182006	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(C(F)(F)F)cc2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4780640	182006	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccc(C(F)(F)F)cc2)ncn1	10.1021/acs.jmedchem.0c01498
	54670455	155799	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	408	4	1	3	5.3	Cc1cc(-c2sc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4059658	155799	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	408	4	1	3	5.3	Cc1cc(-c2sc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653588	185185	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	5	1	4	3.7	CC(=O)c1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4857429	185185	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	5	1	4	3.7	CC(=O)c1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122653600	185687	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	CHEMBL4865212	185687	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	372	4	1	4	3.5	N#Cc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	137640725	157031	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	444	4	1	3	5.8	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(C(F)(F)F)c1	10.1016/j.bmc.2017.03.064
	CHEMBL4073584	157031	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	444	4	1	3	5.8	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(C(F)(F)F)c1	10.1016/j.bmc.2017.03.064
	162644528	179390	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	443	6	3	6	3.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Nc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4739868	179390	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	443	6	3	6	3.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Nc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162655320	180714	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	410	6	2	5	2.8	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4755625	180714	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	410	6	2	5	2.8	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	122653730	180181	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4749272	180181	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	10.1021/acs.jmedchem.0c01498
	122653687	185535	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4862838	185535	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	459	7	2	4	3.8	O=C(NC[C@@H](F)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653670	185515	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4862614	185515	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653730	180181	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4749272	180181	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	441	6	2	4	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653499	186066	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)cc(Cl)c2)c1	nan
	CHEMBL4871179	186066	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)cc(Cl)c2)c1	nan
	137654783	158878	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3cccc(Cl)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4095110	158878	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3cccc(Cl)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	162655975	180785	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	458	7	2	6	3.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(OC(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4756386	180785	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	458	7	2	6	3.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cccc(OC(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	155977949	182009	17	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4780654	182009	17	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	137659986	159215	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	390	4	1	3	5.1	Cc1cc(C(N)=O)ccc1-c1sc(Cc2cccc(C(F)(F)F)c2)nc1C	10.1016/j.bmc.2017.03.064
	CHEMBL4098770	159215	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	390	4	1	3	5.1	Cc1cc(C(N)=O)ccc1-c1sc(Cc2cccc(C(F)(F)F)c2)nc1C	10.1016/j.bmc.2017.03.064
	122653605	186511	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	5	3.8	O=C(N[C@@H]1CCOC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4877497	186511	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	5	3.8	O=C(N[C@@H]1CCOC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	69921128	165070	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	Cc1c(C(=O)NCCO)c(CO)nn1-c1cccc2cc(Cc3cccc(C(F)(F)F)c3)sc12	10.1016/j.bmc.2018.02.005
	CHEMBL4226751	165070	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	Cc1c(C(=O)NCCO)c(CO)nn1-c1cccc2cc(Cc3cccc(C(F)(F)F)c3)sc12	10.1016/j.bmc.2018.02.005
	69921041	165219	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	6	2	5	5.0	Cc1nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c(C)c1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	CHEMBL4229063	165219	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	6	2	5	5.0	Cc1nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c(C)c1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	162660100	181228	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)cnn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4761453	181228	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)cnn1	10.1021/acs.jmedchem.0c01498
	162660762	181257	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	6	3.3	O=C(c1cc(F)cc(C(F)(F)F)c1)c1ccnc(N2CCc3c(C(=O)NCCO)cccc32)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4761816	181257	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	6	3.3	O=C(c1cc(F)cc(C(F)(F)F)c1)c1ccnc(N2CCc3c(C(=O)NCCO)cccc32)n1	10.1021/acs.jmedchem.0c01498
	122653655	186376	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	5	1	4	3.7	CC(=O)c1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1	nan
	CHEMBL4875581	186376	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	371	5	1	4	3.7	CC(=O)c1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1	nan
	137647647	157652	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	352	5	1	4	4.1	COc1cccc(Cc2nc(C)c(-c3ccc(C(N)=O)c(C)c3)s2)c1	10.1016/j.bmc.2017.03.064
	CHEMBL4081439	157652	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	352	5	1	4	4.1	COc1cccc(Cc2nc(C)c(-c3ccc(C(N)=O)c(C)c3)s2)c1	10.1016/j.bmc.2017.03.064
	162652816	180377	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	6	3.3	O=C(c1cc(F)cc(C(F)(F)F)c1)c1cc(N2CCc3c(C(=O)NCCO)cccc32)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4751676	180377	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	6	3.3	O=C(c1cc(F)cc(C(F)(F)F)c1)c1cc(N2CCc3c(C(=O)NCCO)cccc32)ncn1	10.1021/acs.jmedchem.0c01498
	70922254	165065	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	487	7	1	5	5.7	COCCNC(=O)c1c(C)nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1C	10.1016/j.bmc.2018.02.005
	CHEMBL4226695	165065	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	487	7	1	5	5.7	COCCNC(=O)c1c(C)nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1C	10.1016/j.bmc.2018.02.005
	122653422	185955	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	362	4	1	4	3.3	Cc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cnc1F	nan
	CHEMBL4869553	185955	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	362	4	1	4	3.3	Cc1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cnc1F	nan
	137635271	156024	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	406	5	1	4	4.8	COc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4062229	156024	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	406	5	1	4	4.8	COc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653459	184410	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	2	4	3.7	CNC(=O)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4846042	184410	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	468	7	2	4	3.7	CNC(=O)CCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653726	185614	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.7	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NC[C@@H](F)CO)c2)cc1F	nan
	CHEMBL4864048	185614	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.7	COc1ccc(Cc2ccnc(N3CCc4c3ccc(F)c4C(=O)NC[C@@H](F)CO)c2)cc1F	nan
	122653449	184549	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	495	7	2	4	3.5	O=C(NCCN1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4848165	184549	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	495	7	2	4	3.5	O=C(NCCN1CCNC1=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	162656501	180895	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1nccc(Cc2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4757616	180895	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1nccc(Cc2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	59193825	112416	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	441	6	2	3	4.6	O=C(NCCO)c1cccc(-c2cccc3c2OC(Cc2cccc(C(F)(F)F)c2)C3)c1	10.1021/jm5002919
	CHEMBL3297807	112416	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	441	6	2	3	4.6	O=C(NCCO)c1cccc(-c2cccc3c2OC(Cc2cccc(C(F)(F)F)c2)C3)c1	10.1021/jm5002919
	69921479	1371	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	10.1016/j.bmc.2018.02.005
	9804	1371	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	10.1016/j.bmc.2018.02.005
	CHEMBL4228912	1371	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	10.1016/j.bmc.2018.02.005
	122653611	185173	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	387	5	1	5	3.4	CC(=O)Oc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4857269	185173	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	387	5	1	5	3.4	CC(=O)Oc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	122654148	185093	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	CHEMBL4856037	185093	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	471	8	2	5	3.5	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1ccnc(Cc2cc(F)c(F)c(F)c2)c1	nan
	137637645	156222	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3ccc(Cl)cc3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4064577	156222	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3ccc(Cl)cc3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653689	185517	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	401	4	1	5	3.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)OCCCO3)ccn1	nan
	CHEMBL4862638	185517	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	401	4	1	5	3.6	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc3c(c2)OCCCO3)ccn1	nan
	137644761	158491	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	376	4	1	3	4.8	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)cc1	10.1016/j.bmc.2017.03.064
	CHEMBL4091030	158491	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	376	4	1	3	4.8	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)cc1	10.1016/j.bmc.2017.03.064
	122653437	184680	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	404	5	2	4	3.0	CNC(=O)c1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	CHEMBL4849975	184680	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	404	5	2	4	3.0	CNC(=O)c1cc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)ccc1F	nan
	56651044	158146	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	391	4	1	3	4.2	Cc1cc(-c2cc(Cc3cc(F)cc(C(F)(F)F)c3)nn2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4087237	158146	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	391	4	1	3	4.2	Cc1cc(-c2cc(Cc3cc(F)cc(C(F)(F)F)c3)nn2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653604	186081	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	5	1	4	4.4	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(OC(F)(F)F)c2)ccn1	nan
	CHEMBL4871459	186081	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	413	5	1	4	4.4	NC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(OC(F)(F)F)c2)ccn1	nan
	122653668	185379	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	463	5	1	5	4.8	Cn1cc(NC(=O)c2cccc3c2CCN3c2cc(Cc3cc(F)c(F)c(F)c3)ccn2)cn1	nan
	CHEMBL4860543	185379	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	463	5	1	5	4.8	Cn1cc(NC(=O)c2cccc3c2CCN3c2cc(Cc3cc(F)c(F)c(F)c3)ccn2)cn1	nan
	162662725	181894	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	444	6	2	6	3.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Oc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4779168	181894	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	444	6	2	6	3.7	O=C(NCCO)c1cccc2c1CCN2c1cc(Oc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	137649487	157201	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	374	4	1	3	4.9	Cc1cc(-c2sc(Cc3cc(F)cc(Cl)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4075971	157201	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	374	4	1	3	4.9	Cc1cc(-c2sc(Cc3cc(F)cc(Cl)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	137639427	156782	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	340	4	1	3	4.3	Cc1cc(-c2sc(Cc3cccc(F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4070849	156782	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	340	4	1	3	4.3	Cc1cc(-c2sc(Cc3cccc(F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	162644756	179442	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	7	2	5	4.0	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4740473	179442	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	7	2	5	4.0	O=C(NCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	44623954	1136	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	10.1021/jm5002919
	8840	1136	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	10.1021/jm5002919
	CHEMBL3299119	1136	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	10.1021/jm5002919
	59193920	112445	5	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	453	7	1	3	6.3	COCCNC(=O)c1cccc(-c2cccc3cc(Cc4cc(F)cc(Cl)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3298233	112445	5	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	453	7	1	3	6.3	COCCNC(=O)c1cccc(-c2cccc3cc(Cc4cc(F)cc(Cl)c4)sc23)c1	10.1021/jm5002919
	122653478	184509	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	495	6	2	4	4.4	O=C(NC[C@H](O)C(F)(F)F)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4847442	184509	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	495	6	2	4	4.4	O=C(NC[C@H](O)C(F)(F)F)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	162665315	182247	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	374	6	2	5	2.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccccc2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4783576	182247	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	374	6	2	5	2.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccccc2)ncn1	10.1021/acs.jmedchem.0c01498
	122653639	184627	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	421	7	2	5	3.2	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)cc1F	nan
	CHEMBL4849417	184627	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	421	7	2	5	3.2	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCO)cccc43)c2)cc1F	nan
	122653746	186491	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	6	2	4	3.6	O=C(NCCO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4877187	186491	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	445	6	2	4	3.6	O=C(NCCO)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653653	184733	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	485	9	1	5	4.2	COCC(COC)NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4850677	184733	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	485	9	1	5	4.2	COCC(COC)NC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653556	186204	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	469	8	2	5	3.9	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4873066	186204	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	469	8	2	5	3.9	COC[C@@H](O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	162654687	180600	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	478	6	2	5	4.1	O=C(NCCO)c1cccc2c1CCN2c1nccc(C(F)c2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4754435	180600	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	478	6	2	5	4.1	O=C(NCCO)c1cccc2c1CCN2c1nccc(C(F)c2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	162675088	183317	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	478	6	2	5	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(C(F)c2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4797286	183317	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	478	6	2	5	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(C(F)c2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162674993	183371	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	476	6	3	6	3.1	O=C(NCCO)c1cccc2c1CCN2c1cc(C(O)c2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4797830	183371	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	476	6	3	6	3.1	O=C(NCCO)c1cccc2c1CCN2c1cc(C(O)c2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	59193747	112538	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	O=C(NCCO)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)oc23)c1	10.1021/jm5002919
	CHEMBL3299120	112538	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	3	5.4	O=C(NCCO)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)oc23)c1	10.1021/jm5002919
	162655237	180709	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	490	7	3	6	3.0	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4755614	180709	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	490	7	3	6	3.0	O=C(NC(CO)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	122653637	186061	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	363	4	2	4	3.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(O)c(F)c2)ccn1	nan
	CHEMBL4871096	186061	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	363	4	2	4	3.3	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(O)c(F)c2)ccn1	nan
	162672139	182915	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	404	7	2	6	2.5	COc1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	CHEMBL4792434	182915	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	404	7	2	6	2.5	COc1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	122653507	186218	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	450	6	1	4	5.0	N#CCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4873264	186218	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	450	6	1	4	5.0	N#CCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	nan
	122653498	185829	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	2	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(CO)c2)ccn1	nan
	CHEMBL4867455	185829	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	2	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2ccc(F)c(CO)c2)ccn1	nan
	122653457	185070	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NC[C@H](O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4855685	185070	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	504	7	2	5	4.6	O=C(NC[C@H](O)c1cccnc1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	59194084	112540	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	455	6	2	3	5.9	O=C(NCCO)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3299122	112540	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	455	6	2	3	5.9	O=C(NCCO)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	137639301	156955	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	418	5	1	3	6.0	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(C(C)C)c1	10.1016/j.bmc.2017.03.064
	CHEMBL4072782	156955	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	418	5	1	3	6.0	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(C(C)C)c1	10.1016/j.bmc.2017.03.064
	162652119	180343	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	6	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4751311	180343	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	6	4.1	O=C(NCCO)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162677433	183511	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4799772	183511	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	3.6	O=C(NCCO)c1cccc2c1CCN2c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	122653552	185868	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	386	6	1	4	3.5	CN(C)Cc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	CHEMBL4868031	185868	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	386	6	1	4	3.5	CN(C)Cc1cccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)c1	nan
	59193882	112539	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	455	6	2	3	5.9	O=C(NCCO)c1cccc(-c2cccc3sc(Cc4cccc(C(F)(F)F)c4)cc23)c1	10.1021/jm5002919
	CHEMBL3299121	112539	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	455	6	2	3	5.9	O=C(NCCO)c1cccc(-c2cccc3sc(Cc4cccc(C(F)(F)F)c4)cc23)c1	10.1021/jm5002919
	122653447	186453	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	369	4	1	4	4.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc3ccccc3o2)ccn1	nan
	CHEMBL4876570	186453	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	369	4	1	4	4.2	NC(=O)c1cccc2c1CCN2c1cc(Cc2cc3ccccc3o2)ccn1	nan
	59193828	112541	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	4	4.5	O=C(NCCO)c1cccc(-c2cccc3nn(Cc4cccc(C(F)(F)F)c4)cc23)c1	10.1021/jm5002919
	CHEMBL3299123	112541	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	4	4.5	O=C(NCCO)c1cccc(-c2cccc3nn(Cc4cccc(C(F)(F)F)c4)cc23)c1	10.1021/jm5002919
	137648436	157878	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	394	4	1	3	5.0	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(F)c1	10.1016/j.bmc.2017.03.064
	CHEMBL4083957	157878	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	394	4	1	3	5.0	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)c(F)c1	10.1016/j.bmc.2017.03.064
	137648989	157109	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3ccccc3Cl)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4074656	157109	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	356	4	1	3	4.8	Cc1cc(-c2sc(Cc3ccccc3Cl)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	162654874	180588	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	488	8	2	5	4.4	O=C(NCCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4754346	180588	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	488	8	2	5	4.4	O=C(NCCCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162655610	180737	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	476	6	3	6	3.1	O=C(NCCO)c1cccc2c1CCN2c1nccc(C(O)c2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	CHEMBL4755935	180737	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	476	6	3	6	3.1	O=C(NCCO)c1cccc2c1CCN2c1nccc(C(O)c2cc(F)cc(C(F)(F)F)c2)n1	10.1021/acs.jmedchem.0c01498
	137659770	159283	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	377	4	1	4	4.2	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)cn1	10.1016/j.bmc.2017.03.064
	CHEMBL4099457	159283	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	377	4	1	4	4.2	Cc1nc(Cc2cccc(C(F)(F)F)c2)sc1-c1ccc(C(N)=O)cn1	10.1016/j.bmc.2017.03.064
	67185105	112419	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	469	7	1	3	6.6	COCCNC(=O)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3297811	112419	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	469	7	1	3	6.6	COCCNC(=O)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	122653539	185154	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	4	5.0	NC(=O)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4857044	185154	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	415	4	1	4	5.0	NC(=O)c1cccc2c1CCN2c1cc(Sc2cccc(C(F)(F)F)c2)ccn1	nan
	162647123	179527	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	462	6	1	4	4.6	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4741318	179527	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	462	6	1	4	4.6	O=C(NCCF)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	69921111	165194	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	6	2	5	4.6	Cn1nc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)cc1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	CHEMBL4228734	165194	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	6	2	5	4.6	Cn1nc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)cc1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	162649639	180081	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	7	1	5	4.3	COCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4748048	180081	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	7	1	5	4.3	COCCNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	69921074	165042	1	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	6	2	5	4.7	Cc1nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)cc1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	CHEMBL4226295	165042	1	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	6	2	5	4.7	Cc1nn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)cc1C(=O)NCCO	10.1016/j.bmc.2018.02.005
	122653454	184543	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4847995	184543	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	467	5	1	4	4.9	O=C(N[C@H]1CCOC1)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	122653710	185455	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	423	7	1	4	4.2	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCF)cccc43)c2)cc1F	nan
	CHEMBL4861734	185455	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	423	7	1	4	4.2	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCF)cccc43)c2)cc1F	nan
	122653718	185477	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	CHEMBL4862064	185477	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	377	5	1	4	3.6	COc1ccc(Cc2ccnc(N3CCc4c(C(N)=O)cccc43)c2)cc1F	nan
	59193981	112418	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	468	6	2	3	5.4	NC(=O)CNC(=O)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3297810	112418	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	468	6	2	3	5.4	NC(=O)CNC(=O)c1cccc(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	122653716	186128	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	501	7	2	5	3.7	O=C(NCC1(CO)COC1)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4871931	186128	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	501	7	2	5	3.7	O=C(NCC1(CO)COC1)c1c(F)ccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	162668388	182754	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	4.0	O=C(NCCO)c1cccc2c1CCN2c1cc(C(F)c2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4790115	182754	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	460	6	2	5	4.0	O=C(NCCO)c1cccc2c1CCN2c1cc(C(F)c2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162665062	182078	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	458	6	3	6	3.0	O=C(NCCO)c1cccc2c1CCN2c1cc(C(O)c2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4781520	182078	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	458	6	3	6	3.0	O=C(NCCO)c1cccc2c1CCN2c1cc(C(O)c2cccc(C(F)(F)F)c2)ncn1	10.1021/acs.jmedchem.0c01498
	162656735	180850	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	494	6	2	5	4.3	O=C(NCCO)c1cccc2c1CCN2c1nncc(Cc2cc(F)cc(C(F)(F)F)c2)c1Cl	10.1021/acs.jmedchem.0c01498
	CHEMBL4757171	180850	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	494	6	2	5	4.3	O=C(NCCO)c1cccc2c1CCN2c1nncc(Cc2cc(F)cc(C(F)(F)F)c2)c1Cl	10.1021/acs.jmedchem.0c01498
	137661708	159469	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	391	4	1	3	4.3	Cc1cc(-n2cc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4101517	159469	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	391	4	1	3	4.3	Cc1cc(-n2cc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653471	185633	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	8	2	5	3.4	CN(C)CC(O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4864354	185633	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	484	8	2	5	3.4	CN(C)CC(O)CNC(=O)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653560	185814	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)n1	nan
	CHEMBL4867123	185814	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)n1	nan
	122653474	186409	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	380	4	1	4	4.0	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc3ccccc3c2)ccn1	nan
	CHEMBL4876029	186409	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	380	4	1	4	4.0	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc3ccccc3c2)ccn1	nan
	122653651	185100	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	366	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(F)c(F)c2)ccn1	nan
	CHEMBL4856067	185100	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	366	4	1	4	3.1	NC(=O)c1cccc2c1CCN2c1cc(Cc2cnc(F)c(F)c2)ccn1	nan
	70922218	165039	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	7	1	5	5.1	COCCNC(=O)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1016/j.bmc.2018.02.005
	CHEMBL4226253	165039	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	459	7	1	5	5.1	COCCNC(=O)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1016/j.bmc.2018.02.005
	69921013	165069	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	7	1	5	5.4	COCCNC(=O)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1C	10.1016/j.bmc.2018.02.005
	CHEMBL4226750	165069	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	7	1	5	5.4	COCCNC(=O)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1C	10.1016/j.bmc.2018.02.005
	59193856	112542	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	4	4.5	O=C(NCCO)c1cccc(-c2cccc3cn(Cc4cccc(C(F)(F)F)c4)nc23)c1	10.1021/jm5002919
	CHEMBL3299124	112542	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	439	6	2	4	4.5	O=C(NCCO)c1cccc(-c2cccc3cn(Cc4cccc(C(F)(F)F)c4)nc23)c1	10.1021/jm5002919
	59193730	112543	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	441	6	2	3	4.6	O=C(NCCO)c1cccc(-c2cccc3c2CC(Cc2cccc(C(F)(F)F)c2)O3)c1	10.1021/jm5002919
	CHEMBL3299125	112543	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	441	6	2	3	4.6	O=C(NCCO)c1cccc(-c2cccc3c2CC(Cc2cccc(C(F)(F)F)c2)O3)c1	10.1021/jm5002919
	162659255	181232	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	504	8	2	6	3.3	O=C(c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1)N(CCO)CCO	10.1021/acs.jmedchem.0c01498
	CHEMBL4761550	181232	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	504	8	2	6	3.3	O=C(c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1)N(CCO)CCO	10.1021/acs.jmedchem.0c01498
	137653669	158565	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	365	5	1	4	4.2	Cc1cc(-c2sc(Cc3cccc(N(C)C)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4091718	158565	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	365	5	1	4	4.2	Cc1cc(-c2sc(Cc3cccc(N(C)C)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	122653555	186107	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	411	4	1	3	4.7	CNC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	CHEMBL4871721	186107	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	411	4	1	3	4.7	CNC(=O)c1cccc2c1CCN2c1cncc(Cc2cccc(C(F)(F)F)c2)c1	nan
	162662957	181919	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccccc2C(F)(F)F)ncn1	10.1021/acs.jmedchem.0c01498
	CHEMBL4779620	181919	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	442	6	2	5	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2ccccc2C(F)(F)F)ncn1	10.1021/acs.jmedchem.0c01498
	122653438	185522	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4862739	185522	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	489	7	3	5	3.6	O=C(NC[C@H](O)CO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	54670452	157586	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	390	4	1	3	5.1	Cc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4080724	157586	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	390	4	1	3	5.1	Cc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	56649300	157771	30	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4082756	157771	30	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	162670049	182706	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	5	4.0	Cc1c(Cc2cc(F)cc(C(F)(F)F)c2)cnnc1N1CCc2c(C(=O)NCCO)cccc21	10.1021/acs.jmedchem.0c01498
	CHEMBL4789517	182706	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	474	6	2	5	4.0	Cc1c(Cc2cc(F)cc(C(F)(F)F)c2)cnnc1N1CCc2c(C(=O)NCCO)cccc21	10.1021/acs.jmedchem.0c01498
	162668520	182633	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	472	4	1	5	3.7	O=C(c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1)N1CC(O)C1	10.1021/acs.jmedchem.0c01498
	CHEMBL4788591	182633	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	472	4	1	5	3.7	O=C(c1cccc2c1CCN2c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ncn1)N1CC(O)C1	10.1021/acs.jmedchem.0c01498
	122653533	185946	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	465	10	2	6	3.3	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCOCCO)cccc43)c2)cc1F	nan
	CHEMBL4869490	185946	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	465	10	2	6	3.3	COc1ccc(Cc2ccnc(N3CCc4c(C(=O)NCCOCCO)cccc43)c2)cc1F	nan
	118798887	186248	22	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	6	2	4	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4873666	186248	22	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	427	6	2	4	3.5	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653606	184510	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	411	4	1	3	4.8	Cc1cc(Cc2cccc(C(F)(F)F)c2)cc(N2CCc3c(C(N)=O)cccc32)n1	nan
	CHEMBL4847476	184510	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	411	4	1	3	4.8	Cc1cc(Cc2cccc(C(F)(F)F)c2)cc(N2CCc3c(C(N)=O)cccc32)n1	nan
	59193906	112417	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	453	6	2	3	5.7	Cc1c(Cc2cccc(C(F)(F)F)c2)oc2c(-c3cccc(C(=O)NCCO)c3)cccc12	10.1021/jm5002919
	CHEMBL3297809	112417	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	453	6	2	3	5.7	Cc1c(Cc2cccc(C(F)(F)F)c2)oc2c(-c3cccc(C(=O)NCCO)c3)cccc12	10.1021/jm5002919
	137660928	159300	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	404	5	1	3	5.4	CCc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	CHEMBL4099668	159300	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	404	5	1	3	5.4	CCc1cc(-c2sc(Cc3cccc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
	44816186	112446	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	486	6	2	3	5.5	NC(=O)CNC(=O)c1cccc(-c2ccc(F)c3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	CHEMBL3298234	112446	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as cAMP production after 30 mins by Alphascreen assay	ChEMBL	486	6	2	3	5.5	NC(=O)CNC(=O)c1cccc(-c2ccc(F)c3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1021/jm5002919
	162647487	179945	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	434	8	2	7	2.5	COc1cc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)cc(OC)c1	10.1021/acs.jmedchem.0c01498
	CHEMBL4746394	179945	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	434	8	2	7	2.5	COc1cc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)cc(OC)c1	10.1021/acs.jmedchem.0c01498
	70922568	165037	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	445	6	2	5	4.4	O=C(NCCO)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1016/j.bmc.2018.02.005
	CHEMBL4226225	165037	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	445	6	2	5	4.4	O=C(NCCO)c1cnn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)c1	10.1016/j.bmc.2018.02.005
	69921357	165225	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	7	1	5	5.4	COCCNC(=O)c1cn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)nc1C	10.1016/j.bmc.2018.02.005
	CHEMBL4229128	165225	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assayAgonist activity at human GPR52 expressed in CHO cells assessed as increase in cAMP level after 30 mins by AlphaScreen assay	ChEMBL	473	7	1	5	5.4	COCCNC(=O)c1cn(-c2cccc3cc(Cc4cccc(C(F)(F)F)c4)sc23)nc1C	10.1016/j.bmc.2018.02.005
	122653711	185416	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	493	7	2	6	4.2	O=C(Nc1cnn(CCO)c1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	CHEMBL4861218	185416	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	493	7	2	6	4.2	O=C(Nc1cnn(CCO)c1)c1cccc2c1CCN2c1cc(Cc2cc(F)c(F)c(F)c2)ccn1	nan
	122653542	185914	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	CHEMBL4868910	185914	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	425	6	2	4	3.9	O=C(NCCO)c1cccc2c1CCN2c1cc(Cc2cc(F)cc(Cl)c2)ccn1	nan
	162659193	181222	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	388	6	2	5	2.8	Cc1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	CHEMBL4761381	181222	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	388	6	2	5	2.8	Cc1cccc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	56649300	157771	30	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Affinity Phenotypic Cellular interaction (Alphascreen (cAMP increase in human GPR52 expressed CHO cell line)) EUB0000317b GPR52Affinity Phenotypic Cellular interaction (Alphascreen (cAMP increase in human GPR52 expressed CHO cell line)) EUB0000317b GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL5209897
	CHEMBL4082756	157771	30	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Affinity Phenotypic Cellular interaction (Alphascreen (cAMP increase in human GPR52 expressed CHO cell line)) EUB0000317b GPR52Affinity Phenotypic Cellular interaction (Alphascreen (cAMP increase in human GPR52 expressed CHO cell line)) EUB0000317b GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL5209897
	162645603	179510	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	402	6	2	5	3.1	Cc1cc(C)cc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	CHEMBL4741200	179510	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assayAgonist activity at human GPR52 expressed in HEK293 cells assessed as increase in cAMP levels incubated for 15 mins by Glosensor cAMP assay	ChEMBL	402	6	2	5	3.1	Cc1cc(C)cc(Cc2cc(N3CCc4c(C(=O)NCCO)cccc43)ncn2)c1	10.1021/acs.jmedchem.0c01498
	122653404	186279	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	461	6	2	5	4.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Oc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	CHEMBL4874102	186279	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assayAgonist activity at GPR52 (unknown origin) expressed in CHO-K1 or HEK293 cells assessed as intracellular cAMP accumulation incubated for 1 hr by HTRF assay	ChEMBL	461	6	2	5	4.4	O=C(NCCO)c1cccc2c1CCN2c1cc(Oc2cc(F)cc(C(F)(F)F)c2)ccn1	nan
	162671742	182805	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1cccnc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4790746	182805	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1cccnc1	10.1021/acs.jmedchem.0c01133
	162664350	182169	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	240	5	0	3	2.8	Cn1nccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4782590	182169	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	240	5	0	3	2.8	Cn1nccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162646497	179518	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1ccccc1-c1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4741257	179518	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1ccccc1-c1ccccc1	10.1021/acs.jmedchem.0c01133
	162676088	183323	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1cccc(C(=O)/C=C/CCc2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4797370	183323	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1cccc(C(=O)/C=C/CCc2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	162669764	182568	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	226	5	0	2	3.7	O=C(/C=C/CCc1ccccc1)c1ccoc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4787771	182568	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	226	5	0	2	3.7	O=C(/C=C/CCc1ccccc1)c1ccoc1	10.1021/acs.jmedchem.0c01133
	162648761	179953	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	314	5	0	1	4.8	O=C(/C=C/CCc1ccccc1Br)c1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4746541	179953	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	314	5	0	1	4.8	O=C(/C=C/CCc1ccccc1Br)c1ccccc1	10.1021/acs.jmedchem.0c01133
	162670773	182981	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1ccccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4793323	182981	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1ccccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162673688	183156	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	254	5	0	1	4.2	O=C(/C=C/CCc1ccccc1)c1ccccc1F	10.1021/acs.jmedchem.0c01133
	CHEMBL4795327	183156	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	254	5	0	1	4.2	O=C(/C=C/CCc1ccccc1)c1ccccc1F	10.1021/acs.jmedchem.0c01133
	162659243	181206	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	314	5	0	1	4.8	O=C(/C=C/CCc1ccc(Br)cc1)c1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4761208	181206	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	314	5	0	1	4.8	O=C(/C=C/CCc1ccc(Br)cc1)c1ccccc1	10.1021/acs.jmedchem.0c01133
	162672248	182870	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1ccncc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4791780	182870	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1ccncc1	10.1021/acs.jmedchem.0c01133
	162649157	179840	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1ccccn1	10.1021/acs.jmedchem.0c01133
	CHEMBL4745132	179840	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	237	5	0	2	3.5	O=C(/C=C/CCc1ccccc1)c1ccccn1	10.1021/acs.jmedchem.0c01133
	162664011	182205	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	254	5	0	1	4.2	O=C(/C=C/CCc1ccccc1)c1cccc(F)c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4783011	182205	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	254	5	0	1	4.2	O=C(/C=C/CCc1ccccc1)c1cccc(F)c1	10.1021/acs.jmedchem.0c01133
	162659388	181190	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1cccc(C(=O)/C=C/CCc2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4761078	181190	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1cccc(C(=O)/C=C/CCc2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	162648653	179908	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1ccccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4746014	179908	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1ccccc1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162661330	181400	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	264	5	0	1	4.7	Cc1cccc(C)c1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4763588	181400	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	264	5	0	1	4.7	Cc1cccc(C)c1C(=O)/C=C/CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162644983	179460	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1ccc(C(=O)/C=C/CCc2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4740701	179460	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	250	5	0	1	4.4	Cc1ccc(C(=O)/C=C/CCc2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	162650192	180142	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	286	5	0	1	5.2	O=C(/C=C/CCc1ccccc1)c1cccc2ccccc12	10.1021/acs.jmedchem.0c01133
	CHEMBL4748854	180142	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	286	5	0	1	5.2	O=C(/C=C/CCc1ccccc1)c1cccc2ccccc12	10.1021/acs.jmedchem.0c01133
	58517179	181775	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	286	5	0	1	5.2	O=C(/C=C/CCc1ccccc1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4777734	181775	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	286	5	0	1	5.2	O=C(/C=C/CCc1ccccc1)c1ccc2ccccc2c1	10.1021/acs.jmedchem.0c01133
	162660152	181336	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1ccc(C(=O)/C=C/CCc2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4762863	181336	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	266	6	0	2	4.1	COc1ccc(C(=O)/C=C/CCc2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	5316932	91544	24	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	264	7	0	1	4.4	O=C(/C=C/CCc1ccccc1)CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL240484	91544	24	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	264	7	0	1	4.4	O=C(/C=C/CCc1ccccc1)CCc1ccccc1	10.1021/acs.jmedchem.0c01133
	162662933	182014	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	226	5	0	2	3.7	O=C(/C=C/CCc1ccccc1)c1ccco1	10.1021/acs.jmedchem.0c01133
	CHEMBL4780703	182014	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	226	5	0	2	3.7	O=C(/C=C/CCc1ccccc1)c1ccco1	10.1021/acs.jmedchem.0c01133
	10879121	89623	19	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	236	5	0	1	4.1	O=C(/C=C/CCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01133
	CHEMBL2375494	89623	19	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	236	5	0	1	4.1	O=C(/C=C/CCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.0c01133
	162675641	183396	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4798117	183396	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1ccc(-c2ccccc2)cc1	10.1021/acs.jmedchem.0c01133
	162656078	180687	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	CHEMBL4755423	180687	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	312	6	0	1	5.7	O=C(/C=C/CCc1ccccc1)c1cccc(-c2ccccc2)c1	10.1021/acs.jmedchem.0c01133
	156588927	182148	20	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1cccs1	10.1021/acs.jmedchem.0c01133
	CHEMBL4782344	182148	20	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1cccs1	10.1021/acs.jmedchem.0c01133
	162675368	183293	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1ccsc1	10.1021/acs.jmedchem.0c01133
	CHEMBL4796964	183293	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysisAntagonist activity at GPR52 (unknown origin) expressed in HEK293 cells assessed as inhibition of WO459-induced cAMP accumulation preincubated for 15 mins followed by WO459 addition and measured after 30 mins by LANCE Ultra cAMP kit based microplate reader analysis	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1ccsc1	10.1021/acs.jmedchem.0c01133
	44623954	1136	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	24884590
	8840	1136	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	24884590
	CHEMBL3299119	1136	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	439	6	2	3	5.4	OCCNC(=O)c1cccc(c1)c1cccc2c1cc(o2)Cc1cccc(c1)C(F)(F)F	24884590
	69921479	1371	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	29478803
	9804	1371	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	29478803
	CHEMBL4228912	1371	2	None	-	1	Human	7.7	pEC50	=	7.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	489	7	3	6	4.2	OCCNC(=O)c1c(C)nn(c1CO)c1cccc2c1sc(c2)Cc1cccc(c1)C(F)(F)F	29478803

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		CHEMBL5282094	194143	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	404	3	1	4	3.6	Cc1nn(-c2cncc(Cc3cc(F)cc(C(F)(F)F)c3)c2)c2c1C(=O)NCC2	10.1021/acsmedchemlett.3c00052
		CHEMBL5287006	194370	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2c1cnn2-c1cc(Cc2cc(F)cc(C(F)(F)F)c2)ccn1	10.1021/acsmedchemlett.3c00052
		CHEMBL5280513	194073	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2c1cnn2-c1cncc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
		CHEMBL5289682	194476	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	389	3	1	3	3.9	O=C1NCCc2c1cnn2-c1cccc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
		CHEMBL5287950	194402	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	372	4	1	4	3.2	O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
		CHEMBL5277794	193949	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	386	4	1	4	3.5	Cc1nn(-c2ccnc(Cc3cc(F)cc(C(F)F)c3)c2)c2c1C(=O)NCC2	10.1021/acsmedchemlett.3c00052
		CHEMBL5274093	193793	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	404	3	0	4	3.6	CN1CCc2c(cnn2-c2cc(Cc3cc(F)cc(C(F)(F)F)c3)ccn2)C1=O	10.1021/acsmedchemlett.3c00052
		CHEMBL5284809	194266	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	371	3	0	4	4.4	O=C1CCCc2c1cnn2-c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	10.1021/acsmedchemlett.3c00052
		CHEMBL5272124	193709	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	376	3	1	4	3.3	O=C1NCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
		CHEMBL5284353	194252	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
		CHEMBL5278598	193986	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	404	3	1	4	3.6	Cc1nn(-c2ccnc(Cc3cc(F)cc(C(F)(F)F)c3)c2)c2c1C(=O)NCC2	10.1021/acsmedchemlett.3c00052
		CHEMBL5284353	194252	0	None	-	0	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
		90645439	112537	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin)	ChEMBL	414	8	2	4	3.9	O=C(NCCO)c1cccc(-c2cccc(OCCc3cc(F)cc(Cl)c3)n2)c1	10.1021/jm5002919
		CHEMBL3299118	112537	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin)	ChEMBL	414	8	2	4	3.9	O=C(NCCO)c1cccc(-c2cccc(OCCc3cc(F)cc(Cl)c3)n2)c1	10.1021/jm5002919
		CHEMBL5278255	193972	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	424	3	1	4	4.0	O=C1NCCc2c1cnn2-c1ccnc(Cc2cc(F)c(Cl)c(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
		CHEMBL5273936	193786	0	None	-	0	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	404	3	1	4	3.7	O=C1NCCCc2c1cnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
		CHEMBL5291296	194526	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	390	3	1	4	3.3	O=C1NCCc2nn(-c3ccnc(Cc4cc(F)cc(C(F)(F)F)c4)c3)cc21	10.1021/acsmedchemlett.3c00052
		CHEMBL5287320	194380	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	402	5	1	5	3.2	Cc1nn(-c2ccnc(Cc3cc(F)cc(OC(F)F)c3)c2)c2c1C(=O)NCC2	10.1021/acsmedchemlett.3c00052
		CHEMBL5271921	193703	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	372	3	1	4	3.2	O=C1NCCc2c1cnn2-c1cc(Cc2cccc(C(F)(F)F)c2)ccn1	10.1021/acsmedchemlett.3c00052
		CHEMBL5267002	193502	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysisAgonist activity at human GPR52 expressed in HEK293F assessed as cAMP accumulation preincubated for 30 mins followed by cAMP detection reagent and measured after 1 hr by HTRF analysis	ChEMBL	391	3	1	5	2.7	O=C1NCCc2c1nnn2-c1ccnc(Cc2cc(F)cc(C(F)(F)F)c2)c1	10.1021/acsmedchemlett.3c00052
		44206579	112536	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin)	ChEMBL	430	8	2	4	4.1	O=C(NCCO)c1cccc(-c2cccc(OCCc3cccc(C(F)(F)F)c3)n2)c1	10.1021/jm5002919
		CHEMBL3299117	112536	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at GPR52 (unknown origin)Agonist activity at GPR52 (unknown origin)	ChEMBL	430	8	2	4	4.1	O=C(NCCO)c1cccc(-c2cccc(OCCc3cccc(C(F)(F)F)c3)n2)c1	10.1021/jm5002919
		56649300	157771	30	None	-	0	Mouse	7.2	pEC50	=	7.2	Binding	Agonist activity at mouse GPR52Agonist activity at mouse GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
		CHEMBL4082756	157771	30	None	-	0	Mouse	7.2	pEC50	=	7.2	Binding	Agonist activity at mouse GPR52Agonist activity at mouse GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.1016/j.bmc.2017.03.064
		56649300	157771	30	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL5210121
		CHEMBL4082756	157771	30	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52Affinity On-target Cellular interaction (Cell-based cAMP assay) EUB0000317b GPR52	ChEMBL	392	4	1	4	3.7	Cc1cc(-n2nc(Cc3cc(F)cc(C(F)(F)F)c3)nc2C)ccc1C(N)=O	10.6019/CHEMBL5210121
		CHEMBL5279049	194011	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	372	2	0	6	2.9	C=C1C(=O)O[C@@H]2C/C=C(\C)CC3C=C(C[C@H](OC(=O)/C(C)=C\C)[C@@H]12)C(=O)O3	10.1021/acs.jmedchem.2c00799
		5316932	91544	24	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	264	7	0	1	4.4	O=C(/C=C/CCc1ccccc1)CCc1ccccc1	10.1021/acs.jmedchem.2c00799
		CHEMBL240484	91544	24	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	264	7	0	1	4.4	O=C(/C=C/CCc1ccccc1)CCc1ccccc1	10.1021/acs.jmedchem.2c00799
		156588927	182148	20	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1cccs1	10.1021/acs.jmedchem.2c00799
		CHEMBL4782344	182148	20	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	242	5	0	2	4.1	O=C(/C=C/CCc1ccccc1)c1cccs1	10.1021/acs.jmedchem.2c00799
		10879121	89623	19	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	236	5	0	1	4.1	O=C(/C=C/CCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.2c00799
		CHEMBL2375494	89623	19	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of GPR52 (unknown origin)Inhibition of GPR52 (unknown origin)	ChEMBL	236	5	0	1	4.1	O=C(/C=C/CCc1ccccc1)c1ccccc1	10.1021/acs.jmedchem.2c00799

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Main reference

Ligand source activities (1 row/activity)