Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 11467753 | 180975 | 0 | None | - | 1 | Human | 10.8 | pEC50 | = | 10.8 | Functional | ChEMBL | 626 | 6 | 3 | 5 | 4.5 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.01.011 | ||
| CHEMBL454791 | 180975 | 0 | None | - | 1 | Human | 10.8 | pEC50 | = | 10.8 | Functional | ChEMBL | 626 | 6 | 3 | 5 | 4.5 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.01.011 | ||
| 44593666 | 179509 | 7 | None | - | 1 | Human | 10.5 | pEC50 | = | 10.5 | Functional | ChEMBL | 644 | 6 | 3 | 5 | 4.6 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1021/jm800546t | ||
| CHEMBL450668 | 179509 | 7 | None | - | 1 | Human | 10.5 | pEC50 | = | 10.5 | Functional | ChEMBL | 644 | 6 | 3 | 5 | 4.6 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1021/jm800546t | ||
| 51049968 | 89335 | 47 | None | - | 1 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 534 | 3 | 2 | 7 | 4.5 | N[C@@H]1c2cccnc2[C@H](OC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)CC[C@H]1c1cccc(F)c1F | 10.1021/jm3013147 | ||
| CHEMBL2178422 | 89335 | 47 | None | - | 1 | Human | 9.9 | pEC50 | = | 9.9 | Functional | ChEMBL | 534 | 3 | 2 | 7 | 4.5 | N[C@@H]1c2cccnc2[C@H](OC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)CC[C@H]1c1cccc(F)c1F | 10.1021/jm3013147 | ||
| CHEMBL412994 | 219818 | 0 | None | - | 1 | Human | 9.7 | pEC50 | = | 9.7 | Functional | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)[C@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm061343w | ||||
| 24756611 | 83278 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 613 | 5 | 2 | 5 | 5.4 | O=C1CC2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)c2ccccc2N1 | 10.1016/j.bmcl.2012.05.118 | ||
| CHEMBL2059896 | 83278 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 613 | 5 | 2 | 5 | 5.4 | O=C1CC2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)c2ccccc2N1 | 10.1016/j.bmcl.2012.05.118 | ||
| 70694804 | 83282 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 626 | 6 | 2 | 6 | 4.4 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC2(CC1)N=C(c1ccccc1)NC2=O | 10.1016/j.bmcl.2012.05.118 | ||
| CHEMBL2059900 | 83282 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 626 | 6 | 2 | 6 | 4.4 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC2(CC1)N=C(c1ccccc1)NC2=O | 10.1016/j.bmcl.2012.05.118 | ||
| 24756612 | 83280 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 613 | 5 | 2 | 5 | 4.8 | O=C1NCC2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.118 | ||
| CHEMBL2059898 | 83280 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 613 | 5 | 2 | 5 | 4.8 | O=C1NCC2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.118 | ||
| 70694803 | 83279 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 613 | 5 | 2 | 5 | 4.7 | O=C1Cc2ccccc2C2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)N1 | 10.1016/j.bmcl.2012.05.118 | ||
| CHEMBL2059897 | 83279 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 613 | 5 | 2 | 5 | 4.7 | O=C1Cc2ccccc2C2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)N1 | 10.1016/j.bmcl.2012.05.118 | ||
| 62705051 | 83288 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 614 | 5 | 3 | 5 | 5.1 | O=C1Nc2ccccc2C2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)N1 | 10.1016/j.bmcl.2012.05.118 | ||
| CHEMBL2059906 | 83288 | 0 | None | - | 1 | Human | 8.5 | pEC50 | = | 8.5 | Functional | ChEMBL | 614 | 5 | 3 | 5 | 5.1 | O=C1Nc2ccccc2C2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)N1 | 10.1016/j.bmcl.2012.05.118 | ||
| 21102224 | 83287 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 615 | 5 | 2 | 6 | 5.6 | O=C1Nc2ccccc2C2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)O1 | 10.1016/j.bmcl.2012.05.118 | ||
| CHEMBL2059905 | 83287 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 615 | 5 | 2 | 6 | 5.6 | O=C1Nc2ccccc2C2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)O1 | 10.1016/j.bmcl.2012.05.118 | ||
| 11621504 | 180241 | 0 | None | - | 1 | Human | 11.0 | pIC50 | = | 11 | Functional | ChEMBL | 627 | 6 | 2 | 6 | 4.9 | Cc1cc(C[C@@H](OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| CHEMBL452966 | 180241 | 0 | None | - | 1 | Human | 11.0 | pIC50 | = | 11 | Functional | ChEMBL | 627 | 6 | 2 | 6 | 4.9 | Cc1cc(C[C@@H](OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| 11599913 | 195757 | 0 | None | - | 1 | Human | 11.0 | pIC50 | = | 11.0 | Functional | ChEMBL | 645 | 6 | 2 | 6 | 5.0 | Cc1cc(C[C@@H](OC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| CHEMBL508453 | 195757 | 0 | None | - | 1 | Human | 11.0 | pIC50 | = | 11.0 | Functional | ChEMBL | 645 | 6 | 2 | 6 | 5.0 | Cc1cc(C[C@@H](OC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| 11685954 | 195733 | 0 | None | - | 1 | Human | 10.8 | pIC50 | = | 10.8 | Functional | ChEMBL | 624 | 6 | 2 | 6 | 5.1 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| CHEMBL508215 | 195733 | 0 | None | - | 1 | Human | 10.8 | pIC50 | = | 10.8 | Functional | ChEMBL | 624 | 6 | 2 | 6 | 5.1 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| 57404535 | 80573 | 0 | None | - | 1 | Human | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 625 | 7 | 2 | 5 | 4.9 | Cc1cc(C[C@@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018517 | 80573 | 0 | None | - | 1 | Human | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 625 | 7 | 2 | 5 | 4.9 | Cc1cc(C[C@@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| 70696075 | 80890 | 0 | None | - | 1 | Human | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 607 | 7 | 2 | 6 | 6.2 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(CN3CCCCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2022601 | 80890 | 0 | None | - | 1 | Human | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 607 | 7 | 2 | 6 | 6.2 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(CN3CCCCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 11498219 | 178908 | 0 | None | - | 1 | Human | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 624 | 6 | 2 | 6 | 5.1 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCN(C3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| CHEMBL447297 | 178908 | 0 | None | - | 1 | Human | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 624 | 6 | 2 | 6 | 5.1 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCN(C3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| 11549159 | 179545 | 0 | None | - | 1 | Human | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 645 | 6 | 2 | 6 | 5.0 | Cc1cc(C[C@@H](OC(=O)N2CCC(N3Cc4ccc(F)cc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| CHEMBL451164 | 179545 | 0 | None | - | 1 | Human | 10.7 | pIC50 | = | 10.7 | Functional | ChEMBL | 645 | 6 | 2 | 6 | 5.0 | Cc1cc(C[C@@H](OC(=O)N2CCC(N3Cc4ccc(F)cc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| 44593666 | 179509 | 7 | None | - | 1 | Human | 10.6 | pIC50 | = | 10.6 | Functional | ChEMBL | 644 | 6 | 3 | 5 | 4.6 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL450668 | 179509 | 7 | None | - | 1 | Human | 10.6 | pIC50 | = | 10.6 | Functional | ChEMBL | 644 | 6 | 3 | 5 | 4.6 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 70696079 | 80895 | 0 | None | - | 1 | Human | 10.4 | pIC50 | = | 10.4 | Functional | ChEMBL | 618 | 7 | 2 | 6 | 6.8 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(CN3CCCCCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2022606 | 80895 | 0 | None | - | 1 | Human | 10.4 | pIC50 | = | 10.4 | Functional | ChEMBL | 618 | 7 | 2 | 6 | 6.8 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(CN3CCCCCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 11657395 | 195166 | 0 | None | - | 1 | Human | 10.4 | pIC50 | = | 10.4 | Functional | ChEMBL | 624 | 5 | 2 | 6 | 5.0 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCC3(CCN(C)CC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| CHEMBL501603 | 195166 | 0 | None | - | 1 | Human | 10.4 | pIC50 | = | 10.4 | Functional | ChEMBL | 624 | 5 | 2 | 6 | 5.0 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCC3(CCN(C)CC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| 70687597 | 80563 | 0 | None | - | 1 | Human | 10.3 | pIC50 | = | 10.3 | Functional | ChEMBL | 637 | 8 | 2 | 6 | 4.9 | Cc1cc(CC(CC(=O)N2CCC(n3cc(-c4ccccc4)[nH]c3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018507 | 80563 | 0 | None | - | 1 | Human | 10.3 | pIC50 | = | 10.3 | Functional | ChEMBL | 637 | 8 | 2 | 6 | 4.9 | Cc1cc(CC(CC(=O)N2CCC(n3cc(-c4ccccc4)[nH]c3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| 11599798 | 195016 | 0 | None | - | 1 | Human | 10.3 | pIC50 | = | 10.3 | Functional | ChEMBL | 622 | 6 | 2 | 6 | 4.9 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCC(N3CC=CCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| CHEMBL499488 | 195016 | 0 | None | - | 1 | Human | 10.3 | pIC50 | = | 10.3 | Functional | ChEMBL | 622 | 6 | 2 | 6 | 4.9 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCC(N3CC=CCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| 11520204 | 180119 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 642 | 6 | 2 | 6 | 5.3 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4cccc(F)c4[nH]c3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| CHEMBL452686 | 180119 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 642 | 6 | 2 | 6 | 5.3 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4cccc(F)c4[nH]c3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| 164618286 | 191324 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 632 | 4 | 2 | 5 | 4.1 | Cn1c(=O)[nH]c2c(Cl)cc3c(c21)CN(CC(F)(F)F)C(=O)[C@H](CC(=O)N1CCC(N2CCc4ccccc4NC2=O)CC1)C3 | 10.1016/j.bmcl.2021.128077 | ||
| CHEMBL4848032 | 191324 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 632 | 4 | 2 | 5 | 4.1 | Cn1c(=O)[nH]c2c(Cl)cc3c(c21)CN(CC(F)(F)F)C(=O)[C@H](CC(=O)N1CCC(N2CCc4ccccc4NC2=O)CC1)C3 | 10.1016/j.bmcl.2021.128077 | ||
| 11512851 | 195749 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 619 | 6 | 2 | 7 | 4.4 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCN(c3ccncc3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| CHEMBL508349 | 195749 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 619 | 6 | 2 | 7 | 4.4 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCN(c3ccncc3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| 57404529 | 80974 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 612 | 6 | 2 | 6 | 5.8 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(C(=O)N(C)C)cc(Cl)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2023189 | 80974 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 612 | 6 | 2 | 6 | 5.8 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(C(=O)N(C)C)cc(Cl)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 10416497 | 80560 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 625 | 7 | 2 | 5 | 4.9 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018504 | 80560 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 625 | 7 | 2 | 5 | 4.9 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| 11592648 | 195206 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 639 | 7 | 2 | 7 | 4.9 | Cc1cc(C[C@@H](OC(=O)N2CCC(n3cc(-c4ccccc4)[nH]c3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| CHEMBL502243 | 195206 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Functional | ChEMBL | 639 | 7 | 2 | 7 | 4.9 | Cc1cc(C[C@@H](OC(=O)N2CCC(n3cc(-c4ccccc4)[nH]c3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| 46885183 | 15110 | 0 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 488 | 2 | 2 | 7 | 2.7 | O=C1Cn2c(=O)n(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)Nc4ncccc43)c3cccc(c32)N1 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1092882 | 15110 | 0 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 488 | 2 | 2 | 7 | 2.7 | O=C1Cn2c(=O)n(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)Nc4ncccc43)c3cccc(c32)N1 | 10.1016/j.bmcl.2010.02.086 | ||
| 11422298 | 99108 | 0 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 637 | 7 | 3 | 6 | 6.0 | Cc1cc(Cn2ccnc2C(Cc2cc(C)c3[nH]ncc3c2)NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)cc(Cl)n1 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430167 | 99108 | 0 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 637 | 7 | 3 | 6 | 6.0 | Cc1cc(Cn2ccnc2C(Cc2cc(C)c3[nH]ncc3c2)NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)cc(Cl)n1 | 10.1016/j.bmcl.2013.08.031 | ||
| 57404534 | 80575 | 0 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 643 | 7 | 2 | 5 | 5.1 | Cc1cc(C[C@@H](CC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018519 | 80575 | 0 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 643 | 7 | 2 | 5 | 5.1 | Cc1cc(C[C@@H](CC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| 11308219 | 80561 | 0 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 643 | 7 | 2 | 5 | 5.1 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018505 | 80561 | 0 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 643 | 7 | 2 | 5 | 5.1 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| 164614302 | 192121 | 0 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 646 | 5 | 2 | 5 | 4.5 | CCn1c(=O)[nH]c2c(Cl)cc3c(c21)CN(CC(F)(F)F)C(=O)[C@H](CC(=O)N1CCC(N2CCc4ccccc4NC2=O)CC1)C3 | 10.1016/j.bmcl.2021.128077 | ||
| CHEMBL4859941 | 192121 | 0 | None | - | 1 | Human | 10.1 | pIC50 | = | 10.1 | Functional | ChEMBL | 646 | 5 | 2 | 5 | 4.5 | CCn1c(=O)[nH]c2c(Cl)cc3c(c21)CN(CC(F)(F)F)C(=O)[C@H](CC(=O)N1CCC(N2CCc4ccccc4NC2=O)CC1)C3 | 10.1016/j.bmcl.2021.128077 | ||
| 50939479 | 99253 | 1 | None | - | 1 | Human | 10.0 | pIC50 | = | 10.0 | Functional | ChEMBL | 585 | 4 | 2 | 5 | 4.3 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(CC(=O)Nc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | ||
| CHEMBL2431248 | 99253 | 1 | None | - | 1 | Human | 10.0 | pIC50 | = | 10.0 | Functional | ChEMBL | 585 | 4 | 2 | 5 | 4.3 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(CC(=O)Nc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | ||
| 11308069 | 80889 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 621 | 6 | 2 | 6 | 5.8 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(C(=O)N3CCCCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2022600 | 80889 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 621 | 6 | 2 | 6 | 5.8 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(C(=O)N3CCCCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 70681361 | 80892 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 604 | 7 | 2 | 6 | 6.4 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(CN3CCCCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2022603 | 80892 | 0 | None | - | 1 | Human | 10.0 | pIC50 | = | 10 | Functional | ChEMBL | 604 | 7 | 2 | 6 | 6.4 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(CN3CCCCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 164614208 | 191983 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 700 | 5 | 2 | 5 | 5.1 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]c(=O)n(CC(F)(F)F)c3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2021.128077 | ||
| CHEMBL4857649 | 191983 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 700 | 5 | 2 | 5 | 5.1 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]c(=O)n(CC(F)(F)F)c3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2021.128077 | ||
| 70681270 | 80564 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 622 | 7 | 2 | 5 | 5.1 | Cc1cc(CC(CC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018508 | 80564 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 622 | 7 | 2 | 5 | 5.1 | Cc1cc(CC(CC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| 45485692 | 205779 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 530 | 4 | 2 | 4 | 4.7 | CC1(C)CC[C@@H](c2c(F)cccc2F)N(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)Nc3ncccc32)C1=O | 10.1016/j.bmcl.2009.07.134 | ||
| CHEMBL585568 | 205779 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 530 | 4 | 2 | 4 | 4.7 | CC1(C)CC[C@@H](c2c(F)cccc2F)N(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)Nc3ncccc32)C1=O | 10.1016/j.bmcl.2009.07.134 | ||
| 11478962 | 99110 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 603 | 7 | 3 | 6 | 5.3 | Cc1cc(Cn2ccnc2C(Cc2cc(C)c3[nH]ncc3c2)NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)ccn1 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430169 | 99110 | 0 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 603 | 7 | 3 | 6 | 5.3 | Cc1cc(Cn2ccnc2C(Cc2cc(C)c3[nH]ncc3c2)NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)ccn1 | 10.1016/j.bmcl.2013.08.031 | ||
| 11599872 | 195704 | 1 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 636 | 6 | 2 | 6 | 5.1 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCN(c3ccc(F)cc3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| CHEMBL507893 | 195704 | 1 | None | - | 1 | Human | 9.9 | pIC50 | = | 9.9 | Functional | ChEMBL | 636 | 6 | 2 | 6 | 5.1 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCN(c3ccc(F)cc3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| 44583379 | 195040 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 608 | 6 | 1 | 6 | 5.8 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4cn3)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| CHEMBL499810 | 195040 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 608 | 6 | 1 | 6 | 5.8 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4cn3)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| 11204498 | 99118 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 644 | 7 | 3 | 5 | 6.9 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2Cc2ccc(C(C)(C)C)cc2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430177 | 99118 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 644 | 7 | 3 | 5 | 6.9 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2Cc2ccc(C(C)(C)C)cc2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 54581910 | 68290 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 592 | 3 | 2 | 7 | 5.5 | CC1(c2cnc3n2C[C@H](c2cccc(F)c2F)CC[C@H]3NC(=O)N2CCC3(CC2)OC(=O)Nc2ncccc23)CCCO1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770729 | 68290 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 592 | 3 | 2 | 7 | 5.5 | CC1(c2cnc3n2C[C@H](c2cccc(F)c2F)CC[C@H]3NC(=O)N2CCC3(CC2)OC(=O)Nc2ncccc23)CCCO1 | 10.1016/j.bmcl.2010.12.054 | ||
| 46174937 | 83356 | 7 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 519 | 3 | 1 | 6 | 5.0 | O=C(O[C@@H]1CC[C@@H](c2cccc(F)c2F)Cc2cccnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/ml300021s | ||
| CHEMBL2063115 | 83356 | 7 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 519 | 3 | 1 | 6 | 5.0 | O=C(O[C@@H]1CC[C@@H](c2cccc(F)c2F)Cc2cccnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/ml300021s | ||
| 72191391 | 99107 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 633 | 6 | 2 | 7 | 6.4 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2ncc3n2CCN(C2CCCCC2)C3)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430166 | 99107 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Functional | ChEMBL | 633 | 6 | 2 | 7 | 6.4 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2ncc3n2CCN(C2CCCCC2)C3)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 56944164 | 81863 | 3 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 572 | 4 | 3 | 6 | 3.3 | C[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | ||
| CHEMBL2035983 | 81863 | 3 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 572 | 4 | 3 | 6 | 3.3 | C[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | ||
| 54580850 | 68285 | 1 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 580 | 4 | 2 | 7 | 5.3 | COC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770724 | 68285 | 1 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 580 | 4 | 2 | 7 | 5.3 | COC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 54586725 | 68289 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 608 | 6 | 2 | 7 | 6.1 | CCC(CC)(OC)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770728 | 68289 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 608 | 6 | 2 | 7 | 6.1 | CCC(CC)(OC)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 72191392 | 99106 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 641 | 7 | 2 | 7 | 6.2 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2ncc3n2CCN(Cc2ccccc2)C3)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430165 | 99106 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 641 | 7 | 2 | 7 | 6.2 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2ncc3n2CCN(Cc2ccccc2)C3)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 17751102 | 186718 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 602 | 4 | 2 | 4 | 4.8 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | ||
| CHEMBL4746351 | 186718 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 602 | 4 | 2 | 4 | 4.8 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | ||
| 11364682 | 81167 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 538 | 6 | 2 | 6 | 5.0 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(C=O)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024603 | 81167 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 538 | 6 | 2 | 6 | 5.0 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(C=O)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 25181509 | 196144 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 480 | 3 | 3 | 7 | 1.8 | O=C(Cn1c(=O)n2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL512773 | 196144 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 480 | 3 | 3 | 7 | 1.8 | O=C(Cn1c(=O)n2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| 25181509 | 196144 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 480 | 3 | 3 | 7 | 1.8 | O=C(Cn1c(=O)n2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL512773 | 196144 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 480 | 3 | 3 | 7 | 1.8 | O=C(Cn1c(=O)n2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2010.02.086 | ||
| 25181509 | 196144 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 480 | 3 | 3 | 7 | 1.8 | O=C(Cn1c(=O)n2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL512773 | 196144 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Functional | ChEMBL | 480 | 3 | 3 | 7 | 1.8 | O=C(Cn1c(=O)n2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| 59555187 | 111957 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 692 | 8 | 1 | 6 | 6.2 | CC(C)N1CCN(c2c(F)cccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114495 | 111957 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 692 | 8 | 1 | 6 | 6.2 | CC(C)N1CCN(c2c(F)cccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 54585731 | 68276 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 579 | 5 | 2 | 7 | 4.7 | COC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770715 | 68276 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 579 | 5 | 2 | 7 | 4.7 | COC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 54583843 | 68287 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 594 | 5 | 2 | 7 | 5.7 | CCOC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770726 | 68287 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 594 | 5 | 2 | 7 | 5.7 | CCOC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 70685595 | 80973 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 612 | 6 | 2 | 6 | 5.8 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(C(=O)N(C)C)cc(Cl)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2023188 | 80973 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 612 | 6 | 2 | 6 | 5.8 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(C(=O)N(C)C)cc(Cl)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 56944164 | 81863 | 3 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 572 | 4 | 3 | 6 | 3.3 | C[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | ||
| CHEMBL2035983 | 81863 | 3 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 572 | 4 | 3 | 6 | 3.3 | C[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | ||
| 11169454 | 80562 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 611 | 6 | 3 | 5 | 4.6 | Cc1cc(CC(CC(=O)N2CCC3(CC2)NC(=O)Nc2ccccc23)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018506 | 80562 | 0 | None | - | 1 | Human | 9.5 | pIC50 | = | 9.5 | Functional | ChEMBL | 611 | 6 | 3 | 5 | 4.6 | Cc1cc(CC(CC(=O)N2CCC3(CC2)NC(=O)Nc2ccccc23)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| 54580803 | 68258 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 589 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770557 | 68258 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 589 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 72190778 | 99115 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 620 | 7 | 3 | 5 | 6.1 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ncc(C)n2Cc2cccc(F)c2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430174 | 99115 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 620 | 7 | 3 | 5 | 6.1 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ncc(C)n2Cc2cccc(F)c2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 50939479 | 99253 | 1 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 585 | 4 | 2 | 5 | 4.3 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(CC(=O)Nc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | ||
| CHEMBL2431248 | 99253 | 1 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 585 | 4 | 2 | 5 | 4.3 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(CC(=O)Nc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | ||
| 72190777 | 99117 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 702 | 7 | 3 | 5 | 6.7 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nc(Br)cn2Cc2cc(F)cc(F)c2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430176 | 99117 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 702 | 7 | 3 | 5 | 6.7 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nc(Br)cn2Cc2cc(F)cc(F)c2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 11411030 | 99119 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 624 | 7 | 3 | 5 | 5.9 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2Cc2cc(F)cc(F)c2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430178 | 99119 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 624 | 7 | 3 | 5 | 5.9 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2Cc2cc(F)cc(F)c2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 11706981 | 68281 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 590 | 3 | 2 | 6 | 5.5 | O=C1Nc2ncccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)Cn4c(CC(F)(F)F)cnc43)CC2)O1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770720 | 68281 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 590 | 3 | 2 | 6 | 5.5 | O=C1Nc2ncccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)Cn4c(CC(F)(F)F)cnc43)CC2)O1 | 10.1016/j.bmcl.2010.12.054 | ||
| 54586725 | 68289 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 608 | 6 | 2 | 7 | 6.1 | CCC(CC)(OC)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770728 | 68289 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 608 | 6 | 2 | 7 | 6.1 | CCC(CC)(OC)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 11238677 | 99111 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 589 | 7 | 3 | 6 | 5.0 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2Cc2cccnc2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430170 | 99111 | 0 | None | - | 1 | Human | 9.4 | pIC50 | = | 9.4 | Functional | ChEMBL | 589 | 7 | 3 | 6 | 5.0 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2Cc2cccnc2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 11786642 | 81159 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 588 | 5 | 2 | 5 | 6.0 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cccc(Br)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024595 | 81159 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 588 | 5 | 2 | 5 | 6.0 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cccc(Br)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 46885244 | 14565 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 487 | 2 | 2 | 5 | 4.2 | CC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@@]1(C4)C(=O)Nc3ncccc31)C2 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1089433 | 14565 | 0 | None | - | 1 | Human | 9.3 | pIC50 | = | 9.3 | Functional | ChEMBL | 487 | 2 | 2 | 5 | 4.2 | CC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@@]1(C4)C(=O)Nc3ncccc31)C2 | 10.1016/j.bmcl.2010.02.086 | ||
| 59554856 | 111958 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 706 | 7 | 1 | 6 | 6.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)SC1c1cccc(F)c1N1CCN(C(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114496 | 111958 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 706 | 7 | 1 | 6 | 6.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)SC1c1cccc(F)c1N1CCN(C(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 54581909 | 68284 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 552 | 4 | 2 | 7 | 4.6 | COCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770723 | 68284 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 552 | 4 | 2 | 7 | 4.6 | COCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 54585731 | 68276 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 579 | 5 | 2 | 7 | 4.7 | COC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770715 | 68276 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 579 | 5 | 2 | 7 | 4.7 | COC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 45267476 | 203063 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 463 | 3 | 3 | 5 | 3.2 | O=C(Cn1cc2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL562069 | 203063 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 463 | 3 | 3 | 5 | 3.2 | O=C(Cn1cc2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| 11606400 | 68269 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 549 | 4 | 2 | 6 | 5.0 | CC(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770568 | 68269 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 549 | 4 | 2 | 6 | 5.0 | CC(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 25181509 | 196144 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 480 | 3 | 3 | 7 | 1.8 | O=C(Cn1c(=O)n2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL512773 | 196144 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 480 | 3 | 3 | 7 | 1.8 | O=C(Cn1c(=O)n2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| 25181509 | 196144 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 480 | 3 | 3 | 7 | 1.8 | O=C(Cn1c(=O)n2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL512773 | 196144 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 480 | 3 | 3 | 7 | 1.8 | O=C(Cn1c(=O)n2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2010.02.086 | ||
| 45485605 | 204433 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 516 | 3 | 3 | 6 | 2.7 | NCC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@]1(C4)C(=O)Nc3ncccc31)C2=O | 10.1016/j.bmcl.2009.07.134 | ||
| CHEMBL570933 | 204433 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 516 | 3 | 3 | 6 | 2.7 | NCC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@]1(C4)C(=O)Nc3ncccc31)C2=O | 10.1016/j.bmcl.2009.07.134 | ||
| 25181509 | 196144 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 480 | 3 | 3 | 7 | 1.8 | O=C(Cn1c(=O)n2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL512773 | 196144 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 480 | 3 | 3 | 7 | 1.8 | O=C(Cn1c(=O)n2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| 54580838 | 68275 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 551 | 5 | 2 | 7 | 4.0 | COCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770714 | 68275 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 551 | 5 | 2 | 7 | 4.0 | COCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 54580850 | 68285 | 1 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 580 | 4 | 2 | 7 | 5.3 | COC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770724 | 68285 | 1 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 580 | 4 | 2 | 7 | 5.3 | COC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 11295951 | 81163 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 560 | 5 | 2 | 5 | 6.4 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc3ccccc3cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024599 | 81163 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 560 | 5 | 2 | 5 | 6.4 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc3ccccc3cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 11250445 | 99120 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 606 | 7 | 3 | 5 | 5.8 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2Cc2cccc(F)c2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430179 | 99120 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 606 | 7 | 3 | 5 | 5.8 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2Cc2cccc(F)c2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 54583844 | 68288 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 648 | 5 | 2 | 7 | 6.3 | CC(C)(OCC(F)(F)F)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770727 | 68288 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 648 | 5 | 2 | 7 | 6.3 | CC(C)(OCC(F)(F)F)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 46885299 | 14980 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 501 | 3 | 2 | 5 | 4.6 | CCC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@@]1(C4)C(=O)Nc3ncccc31)C2 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1092208 | 14980 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 501 | 3 | 2 | 5 | 4.6 | CCC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@@]1(C4)C(=O)Nc3ncccc31)C2 | 10.1016/j.bmcl.2010.02.086 | ||
| 24756690 | 80559 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 612 | 6 | 2 | 6 | 5.0 | Cc1cc(CC(CC(=O)N2CCC3(CC2)OC(=O)Nc2ccccc23)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018503 | 80559 | 0 | None | - | 1 | Human | 9.2 | pIC50 | = | 9.2 | Functional | ChEMBL | 612 | 6 | 2 | 6 | 5.0 | Cc1cc(CC(CC(=O)N2CCC3(CC2)OC(=O)Nc2ccccc23)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| 54581910 | 68290 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 592 | 3 | 2 | 7 | 5.5 | CC1(c2cnc3n2C[C@H](c2cccc(F)c2F)CC[C@H]3NC(=O)N2CCC3(CC2)OC(=O)Nc2ncccc23)CCCO1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770729 | 68290 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 592 | 3 | 2 | 7 | 5.5 | CC1(c2cnc3n2C[C@H](c2cccc(F)c2F)CC[C@H]3NC(=O)N2CCC3(CC2)OC(=O)Nc2ncccc23)CCCO1 | 10.1016/j.bmcl.2010.12.054 | ||
| 57794685 | 99126 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 588 | 7 | 3 | 5 | 5.6 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2Cc2ccccc2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430185 | 99126 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 588 | 7 | 3 | 5 | 5.6 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2Cc2ccccc2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 54586710 | 68280 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 564 | 4 | 2 | 6 | 4.8 | COC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770719 | 68280 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 564 | 4 | 2 | 6 | 4.8 | COC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 11215446 | 81158 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 587 | 5 | 3 | 4 | 5.5 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cccc(Br)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024594 | 81158 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 587 | 5 | 3 | 4 | 5.5 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cccc(Br)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 54583842 | 68283 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 591 | 3 | 2 | 7 | 4.9 | O=C1Nc2ncccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)Cn4c(CC(F)(F)F)nnc43)CC2)O1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770722 | 68283 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 591 | 3 | 2 | 7 | 4.9 | O=C1Nc2ncccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)Cn4c(CC(F)(F)F)nnc43)CC2)O1 | 10.1016/j.bmcl.2010.12.054 | ||
| 11478841 | 99109 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 589 | 7 | 3 | 6 | 5.0 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2Cc2ccncc2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430168 | 99109 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 589 | 7 | 3 | 6 | 5.0 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2Cc2ccncc2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 54587762 | 68286 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 566 | 3 | 3 | 7 | 4.7 | CC(C)(O)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770725 | 68286 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 566 | 3 | 3 | 7 | 4.7 | CC(C)(O)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 46885242 | 15099 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 473 | 2 | 2 | 5 | 4.1 | O=C1CC2CN(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)Nc4ncccc43)c3cccc(c32)N1 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1092837 | 15099 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 473 | 2 | 2 | 5 | 4.1 | O=C1CC2CN(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)Nc4ncccc43)c3cccc(c32)N1 | 10.1016/j.bmcl.2010.02.086 | ||
| 44570616 | 196993 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 538 | 5 | 2 | 7 | 2.5 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)Nc3ncccc31)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL517467 | 196993 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 538 | 5 | 2 | 7 | 2.5 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)Nc3ncccc31)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.106 | ||
| 11456201 | 99123 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 602 | 8 | 3 | 5 | 5.8 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2CCc2ccccc2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430182 | 99123 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 602 | 8 | 3 | 5 | 5.8 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2CCc2ccccc2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 46905052 | 17190 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 488 | 3 | 2 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2C | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL1162991 | 17190 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 488 | 3 | 2 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2C | 10.1016/j.bmcl.2009.06.057 | ||
| 44593545 | 185233 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 474 | 3 | 3 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL466192 | 185233 | 0 | None | - | 1 | Human | 9.1 | pIC50 | = | 9.1 | Functional | ChEMBL | 474 | 3 | 3 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2 | 10.1016/j.bmcl.2008.10.106 | ||
| 71819577 | 152079 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 552 | 3 | 3 | 6 | 4.2 | N[C@@H]1c2cccnc2[C@H](NC(=O)c2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)CC[C@H]1c1cccc(F)c1F | nan | ||
| CHEMBL3913150 | 152079 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 552 | 3 | 3 | 6 | 4.2 | N[C@@H]1c2cccnc2[C@H](NC(=O)c2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)CC[C@H]1c1cccc(F)c1F | nan | ||
| 54587752 | 68277 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 574 | 3 | 2 | 5 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)cnc21)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770716 | 68277 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 574 | 3 | 2 | 5 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)cnc21)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 11341642 | 81153 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 536 | 7 | 2 | 5 | 4.8 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc(C=O)cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024589 | 81153 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 536 | 7 | 2 | 5 | 4.8 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc(C=O)cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 11250446 | 99121 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 606 | 7 | 3 | 5 | 5.8 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2Cc2ccc(F)cc2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430180 | 99121 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9.0 | Functional | ChEMBL | 606 | 7 | 3 | 5 | 5.8 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2Cc2ccc(F)cc2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 11467108 | 81162 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 559 | 5 | 3 | 4 | 5.9 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc3ccccc3cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024598 | 81162 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 559 | 5 | 3 | 4 | 5.9 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc3ccccc3cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 76321477 | 111982 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 706 | 7 | 1 | 6 | 6.6 | CC(C)(C)CCN1C(=O)[C@H](CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)S[C@@H]1c1cccc(F)c1N1CCN(C(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114676 | 111982 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 706 | 7 | 1 | 6 | 6.6 | CC(C)(C)CCN1C(=O)[C@H](CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)S[C@@H]1c1cccc(F)c1N1CCN(C(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 23656921 | 96997 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 596 | 6 | 2 | 6 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCOC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL238276 | 96997 | 0 | None | - | 1 | Human | 9.0 | pIC50 | = | 9 | Functional | ChEMBL | 596 | 6 | 2 | 6 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCOC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 46885185 | 14741 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 502 | 2 | 1 | 7 | 2.8 | CN1C(=O)Cn2c(=O)n(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)Nc4ncccc43)c3cccc1c32 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1090515 | 14741 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 502 | 2 | 1 | 7 | 2.8 | CN1C(=O)Cn2c(=O)n(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)Nc4ncccc43)c3cccc1c32 | 10.1016/j.bmcl.2010.02.086 | ||
| 54583842 | 68283 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 591 | 3 | 2 | 7 | 4.9 | O=C1Nc2ncccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)Cn4c(CC(F)(F)F)nnc43)CC2)O1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770722 | 68283 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 591 | 3 | 2 | 7 | 4.9 | O=C1Nc2ncccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)Cn4c(CC(F)(F)F)nnc43)CC2)O1 | 10.1016/j.bmcl.2010.12.054 | ||
| 11192748 | 81154 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 605 | 8 | 2 | 5 | 6.0 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc(CN3CCCCC3)cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024590 | 81154 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 605 | 8 | 2 | 5 | 6.0 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc(CN3CCCCC3)cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 45267481 | 203441 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 479 | 3 | 3 | 5 | 3.1 | CC12CC(=O)Nc3cccc(c31)N(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)Nc3ncccc31)C2 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL564487 | 203441 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 479 | 3 | 3 | 5 | 3.1 | CC12CC(=O)Nc3cccc(c31)N(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)Nc3ncccc31)C2 | 10.1016/j.bmcl.2009.06.057 | ||
| 46885244 | 14565 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 487 | 2 | 2 | 5 | 4.2 | CC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@@]1(C4)C(=O)Nc3ncccc31)C2 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1089433 | 14565 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 487 | 2 | 2 | 5 | 4.2 | CC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@@]1(C4)C(=O)Nc3ncccc31)C2 | 10.1016/j.bmcl.2010.02.086 | ||
| 11520007 | 68278 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 600 | 3 | 2 | 5 | 5.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(C3(C(F)(F)F)CC3)cnc21)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770717 | 68278 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 600 | 3 | 2 | 5 | 5.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(C3(C(F)(F)F)CC3)cnc21)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 54586710 | 68280 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 564 | 4 | 2 | 6 | 4.8 | COC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770719 | 68280 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 564 | 4 | 2 | 6 | 4.8 | COC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 11226747 | 81160 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 559 | 5 | 3 | 4 | 5.9 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc3ccccc3n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024596 | 81160 | 0 | None | - | 1 | Human | 8.9 | pIC50 | = | 8.9 | Functional | ChEMBL | 559 | 5 | 3 | 4 | 5.9 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc3ccccc3n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 54587762 | 68286 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 566 | 3 | 3 | 7 | 4.7 | CC(C)(O)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770725 | 68286 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 566 | 3 | 3 | 7 | 4.7 | CC(C)(O)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 46885299 | 14980 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 501 | 3 | 2 | 5 | 4.6 | CCC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@@]1(C4)C(=O)Nc3ncccc31)C2 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1092208 | 14980 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 501 | 3 | 2 | 5 | 4.6 | CCC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@@]1(C4)C(=O)Nc3ncccc31)C2 | 10.1016/j.bmcl.2010.02.086 | ||
| 54582783 | 68257 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 548 | 4 | 2 | 7 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(C3CC3)nnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770556 | 68257 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 548 | 4 | 2 | 7 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(C3CC3)nnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 11456078 | 99112 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 589 | 7 | 3 | 6 | 5.0 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2Cc2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430171 | 99112 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 589 | 7 | 3 | 6 | 5.0 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2Cc2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 44570579 | 197610 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 503 | 4 | 2 | 8 | 2.6 | O=C(Cn1c(=O)n(-c2ccncn2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL518422 | 197610 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 503 | 4 | 2 | 8 | 2.6 | O=C(Cn1c(=O)n(-c2ccncn2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| 54581897 | 68279 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 536 | 4 | 2 | 6 | 4.0 | COCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770718 | 68279 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 536 | 4 | 2 | 6 | 4.0 | COCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 54581909 | 68284 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 552 | 4 | 2 | 7 | 4.6 | COCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770723 | 68284 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 552 | 4 | 2 | 7 | 4.6 | COCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 73355345 | 99105 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 579 | 6 | 2 | 7 | 5.0 | CCN1CCn2c(cnc2C(Cc2cc(C)c3[nH]ncc3c2)OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C1 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430164 | 99105 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 579 | 6 | 2 | 7 | 5.0 | CCN1CCn2c(cnc2C(Cc2cc(C)c3[nH]ncc3c2)OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C1 | 10.1016/j.bmcl.2013.08.031 | ||
| 46885135 | 14808 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 468 | 2 | 2 | 7 | 1.4 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(Cn4c(=O)n5c6c(cccc64)NC(=O)C5)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1090848 | 14808 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Functional | ChEMBL | 468 | 2 | 2 | 7 | 1.4 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(Cn4c(=O)n5c6c(cccc64)NC(=O)C5)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| 11599135 | 195080 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 541 | 5 | 2 | 5 | 4.7 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCCCC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| CHEMBL500384 | 195080 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 541 | 5 | 2 | 5 | 4.7 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCCCC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2009.04.150 | ||
| 54580838 | 68275 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 551 | 5 | 2 | 7 | 4.0 | COCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770714 | 68275 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 551 | 5 | 2 | 7 | 4.0 | COCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 11466363 | 81157 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 510 | 5 | 2 | 5 | 5.2 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024593 | 81157 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 510 | 5 | 2 | 5 | 5.2 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 11169408 | 99122 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 606 | 7 | 3 | 5 | 5.8 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2Cc2ccccc2F)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430181 | 99122 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 606 | 7 | 3 | 5 | 5.8 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2Cc2ccccc2F)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 44563028 | 201345 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 447 | 3 | 2 | 6 | 1.6 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2C | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL530116 | 201345 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 447 | 3 | 2 | 6 | 1.6 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2C | 10.1016/j.bmcl.2008.10.019 | ||
| 59555048 | 111948 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2[C@@H]2S[C@H](CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114486 | 111948 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2[C@@H]2S[C@H](CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 11387595 | 153760 | 1 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 575 | 5 | 2 | 6 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(Cc2ccccn2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL392635 | 153760 | 1 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 575 | 5 | 2 | 6 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(Cc2ccccn2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 11752904 | 154129 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 530 | 5 | 2 | 5 | 3.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCF)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL392937 | 154129 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 530 | 5 | 2 | 5 | 3.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCF)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 44570498 | 190819 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 483 | 4 | 2 | 8 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccncn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL482178 | 190819 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8 | Functional | ChEMBL | 483 | 4 | 2 | 8 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccncn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| 44416824 | 87058 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 542 | 4 | 2 | 5 | 2.5 | O=C1CN(C2CCN(C(=O)N[C@@H]3N=C(c4ccccc4)c4ccccc4N(CC(F)(F)F)C3=O)CC2)C(=O)N1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL213976 | 87058 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 542 | 4 | 2 | 5 | 2.5 | O=C1CN(C2CCN(C(=O)N[C@@H]3N=C(c4ccccc4)c4ccccc4N(CC(F)(F)F)C3=O)CC2)C(=O)N1 | 10.1016/j.bmcl.2006.07.044 | ||
| 135461116 | 148331 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 603 | 5 | 2 | 7 | 4.8 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2nc(-c3ccccc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL384799 | 148331 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 603 | 5 | 2 | 7 | 4.8 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2nc(-c3ccccc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 58864267 | 80547 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 649 | 7 | 3 | 5 | 4.7 | O=C(Nc1ccccc1Cl)N[C@@H](CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCC(N2CCCCC2)CC1 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018491 | 80547 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 649 | 7 | 3 | 5 | 4.7 | O=C(Nc1ccccc1Cl)N[C@@H](CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCC(N2CCCCC2)CC1 | 10.1016/j.bmcl.2012.02.066 | ||
| 23656587 | 96996 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 464 | 3 | 4 | 6 | 1.8 | O=C1NCC(c2ccc(O)cc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL238275 | 96996 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 464 | 3 | 4 | 6 | 1.8 | O=C1NCC(c2ccc(O)cc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 11848908 | 102220 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 524 | 6 | 2 | 7 | 3.3 | COCCn1cc(-c2cccc(F)c2F)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL257094 | 102220 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 524 | 6 | 2 | 7 | 3.3 | COCCn1cc(-c2cccc(F)c2F)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 11848647 | 162142 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 445 | 3 | 2 | 7 | 2.4 | Cn1cc(-c2cccnc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL403373 | 162142 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 445 | 3 | 2 | 7 | 2.4 | Cn1cc(-c2cccnc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 44416912 | 87632 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 620 | 5 | 2 | 6 | 5.5 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccc(F)cc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL215274 | 87632 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 620 | 5 | 2 | 6 | 5.5 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccc(F)cc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 16115156 | 103981 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 1221 | 29 | 12 | 14 | -1.3 | CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)[C@@H](C)O)C(=O)N[C@H]1CC[C@H]2CC[C@@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)N2C1=O | 10.1021/jm061343w | ||
| CHEMBL268420 | 103981 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 1221 | 29 | 12 | 14 | -1.3 | CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)[C@@H](C)O)C(=O)N[C@H]1CC[C@H]2CC[C@@H](C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc3ccccc3)C(N)=O)N2C1=O | 10.1021/jm061343w | ||
| 11495985 | 102445 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 444 | 3 | 2 | 6 | 3.0 | Cn1cc(-c2ccccc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL258070 | 102445 | 0 | None | - | 1 | Human | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 444 | 3 | 2 | 6 | 3.0 | Cn1cc(-c2ccccc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1021/jm500364u | ||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1021/jm500364u | ||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 70689654 | 80574 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 625 | 7 | 2 | 5 | 4.9 | Cc1cc(C[C@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018518 | 80574 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 625 | 7 | 2 | 5 | 4.9 | Cc1cc(C[C@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1021/jm070668p | ||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2009.06.057 | ||
| 11526993 | 204371 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 565 | 3 | 2 | 4 | 4.1 | O=C1CC2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)c2cccnc2N1 | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL570531 | 204371 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 565 | 3 | 2 | 4 | 4.1 | O=C1CC2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)c2cccnc2N1 | 10.1016/j.bmcl.2009.09.066 | ||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2009.09.066 | ||
| 11526993 | 204371 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 565 | 3 | 2 | 4 | 4.1 | O=C1CC2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)c2cccnc2N1 | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL570531 | 204371 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 565 | 3 | 2 | 4 | 4.1 | O=C1CC2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)c2cccnc2N1 | 10.1016/j.bmcl.2009.09.066 | ||
| 11584808 | 204467 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 551 | 3 | 2 | 4 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL571203 | 204467 | 0 | None | - | 1 | Human | 8.0 | pIC50 | = | 8.0 | Functional | ChEMBL | 551 | 3 | 2 | 4 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2009.09.066 | ||
| 44420228 | 91012 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 405 | 3 | 3 | 5 | 1.0 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL221009 | 91012 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 405 | 3 | 3 | 5 | 1.0 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 44420255 | 144663 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 483 | 4 | 2 | 8 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ncccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL376292 | 144663 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 483 | 4 | 2 | 8 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ncccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| 72194610 | 159370 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 503 | 3 | 2 | 6 | 3.6 | O=C(NC1COC(c2ccccc2)Cc2cccnc21)c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| CHEMBL3971889 | 159370 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 503 | 3 | 2 | 6 | 3.6 | O=C(NC1COC(c2ccccc2)Cc2cccnc21)c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| 11432505 | 204412 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 527 | 4 | 2 | 4 | 3.3 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(c2ccn[nH]c2=O)CC1 | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL570793 | 204412 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 527 | 4 | 2 | 4 | 3.3 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(c2ccn[nH]c2=O)CC1 | 10.1016/j.bmcl.2009.09.066 | ||
| 11215322 | 148556 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 577 | 4 | 2 | 7 | 4.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3cccnc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL386113 | 148556 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 577 | 4 | 2 | 7 | 4.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3cccnc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 11848966 | 102177 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 530 | 4 | 2 | 6 | 4.1 | O=C(Nc1cc(-c2cccc(F)c2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL256901 | 102177 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 530 | 4 | 2 | 6 | 4.1 | O=C(Nc1cc(-c2cccc(F)c2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| 11848857 | 101986 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 489 | 6 | 2 | 8 | 2.5 | COCCn1cc(-c2cccnc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL255999 | 101986 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 489 | 6 | 2 | 8 | 2.5 | COCCn1cc(-c2cccnc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 44563200 | 181269 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 502 | 3 | 2 | 7 | 1.2 | CN1C(=O)CCCn2c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c3cccc1c32 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL455458 | 181269 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 502 | 3 | 2 | 7 | 1.2 | CN1C(=O)CCCn2c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c3cccc1c32 | 10.1016/j.bmcl.2008.10.019 | ||
| 44593445 | 198308 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 518 | 5 | 2 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL519421 | 198308 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 518 | 5 | 2 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.019 | ||
| 11678239 | 68261 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 537 | 4 | 3 | 7 | 3.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2cc(CO)nc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770560 | 68261 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 537 | 4 | 3 | 7 | 3.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2cc(CO)nc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 54582784 | 68265 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 564 | 6 | 3 | 7 | 3.6 | CNCCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770564 | 68265 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 564 | 6 | 3 | 7 | 3.6 | CNCCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 54581838 | 68263 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 521 | 3 | 2 | 6 | 4.2 | Cc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770562 | 68263 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 521 | 3 | 2 | 6 | 4.2 | Cc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 54583774 | 68264 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 537 | 4 | 3 | 7 | 3.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CO)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770563 | 68264 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 537 | 4 | 3 | 7 | 3.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CO)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 44593445 | 198308 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 518 | 5 | 2 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL519421 | 198308 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 518 | 5 | 2 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.106 | ||
| 44563125 | 180606 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 504 | 6 | 2 | 7 | 0.9 | CN(C)C(=O)CCn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2ccccc21 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL453865 | 180606 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 504 | 6 | 2 | 7 | 0.9 | CN(C)C(=O)CCn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2ccccc21 | 10.1016/j.bmcl.2008.10.019 | ||
| 58864421 | 80553 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 629 | 7 | 3 | 9 | 2.7 | Cc1nc(N[C@@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)nc2nn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018497 | 80553 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 629 | 7 | 3 | 9 | 2.7 | Cc1nc(N[C@@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)nc2nn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| 11375696 | 99116 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 512 | 5 | 4 | 4 | 4.4 | Cc1c[nH]c(C(Cc2cc(C)c3[nH]ncc3c2)NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)n1 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430175 | 99116 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 512 | 5 | 4 | 4 | 4.4 | Cc1c[nH]c(C(Cc2cc(C)c3[nH]ncc3c2)NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)n1 | 10.1016/j.bmcl.2013.08.031 | ||
| 11351794 | 97755 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NC[C@H](c2ccccc2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL239630 | 97755 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NC[C@H](c2ccccc2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 11599531 | 205225 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 578 | 4 | 2 | 3 | 4.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)CC(c1ccccc1)NC2=O | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL577320 | 205225 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 578 | 4 | 2 | 3 | 4.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)CC(c1ccccc1)NC2=O | 10.1016/j.bmcl.2009.09.066 | ||
| 44420228 | 91012 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 405 | 3 | 3 | 5 | 1.0 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL221009 | 91012 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 405 | 3 | 3 | 5 | 1.0 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| 44420228 | 91012 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 405 | 3 | 3 | 5 | 1.0 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL221009 | 91012 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 405 | 3 | 3 | 5 | 1.0 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 44562936 | 185715 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 423 | 3 | 3 | 5 | 1.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4c(F)cccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL470321 | 185715 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 423 | 3 | 3 | 5 | 1.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4c(F)cccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 44563025 | 199274 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 423 | 3 | 3 | 5 | 1.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccc(F)cc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL520905 | 199274 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 423 | 3 | 3 | 5 | 1.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccc(F)cc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 44563028 | 201345 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 447 | 3 | 2 | 6 | 1.6 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2C | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL530116 | 201345 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 447 | 3 | 2 | 6 | 1.6 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2C | 10.1016/j.bmcl.2008.10.019 | ||
| 46885184 | 15111 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 482 | 2 | 1 | 7 | 1.4 | CN1C(=O)Cn2c(=O)n(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)NC(=O)N3C)c3cccc1c32 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1092883 | 15111 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 482 | 2 | 1 | 7 | 1.4 | CN1C(=O)Cn2c(=O)n(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)NC(=O)N3C)c3cccc1c32 | 10.1016/j.bmcl.2010.02.086 | ||
| 11706251 | 205304 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 517 | 3 | 3 | 4 | 2.0 | O=C1NC(=O)C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)N1 | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL577957 | 205304 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 517 | 3 | 3 | 4 | 2.0 | O=C1NC(=O)C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)N1 | 10.1016/j.bmcl.2009.09.066 | ||
| 59555056 | 111922 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 508 | 7 | 1 | 5 | 3.7 | COCCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114460 | 111922 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 508 | 7 | 1 | 5 | 3.7 | COCCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| 44563052 | 192814 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 490 | 5 | 3 | 7 | 0.6 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(N)=O | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL487068 | 192814 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 490 | 5 | 3 | 7 | 0.6 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(N)=O | 10.1016/j.bmcl.2008.10.019 | ||
| 44563200 | 181269 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 502 | 3 | 2 | 7 | 1.2 | CN1C(=O)CCCn2c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c3cccc1c32 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL455458 | 181269 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 502 | 3 | 2 | 7 | 1.2 | CN1C(=O)CCCn2c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c3cccc1c32 | 10.1016/j.bmcl.2008.10.019 | ||
| 54583844 | 68288 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 648 | 5 | 2 | 7 | 6.3 | CC(C)(OCC(F)(F)F)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770727 | 68288 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 648 | 5 | 2 | 7 | 6.3 | CC(C)(OCC(F)(F)F)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 11191890 | 81075 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 536 | 7 | 2 | 4 | 5.6 | CCc1ccnc(C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)Cc2cc(C)c3[nH]ncc3c2)c1 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024172 | 81075 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 536 | 7 | 2 | 4 | 5.6 | CCc1ccnc(C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)Cc2cc(C)c3[nH]ncc3c2)c1 | 10.1016/j.bmcl.2012.02.065 | ||
| 46905052 | 17190 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 488 | 3 | 2 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2C | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL1162991 | 17190 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 488 | 3 | 2 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2C | 10.1016/j.bmcl.2009.06.057 | ||
| 45487036 | 204405 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 541 | 4 | 2 | 4 | 3.6 | Cc1cc(C2CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)c(=O)[nH]n1 | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL570748 | 204405 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 541 | 4 | 2 | 4 | 3.6 | Cc1cc(C2CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)c(=O)[nH]n1 | 10.1016/j.bmcl.2009.09.066 | ||
| 11692628 | 204404 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 567 | 3 | 2 | 5 | 4.3 | O=C1Nc2ncccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)O1 | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL570746 | 204404 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 567 | 3 | 2 | 5 | 4.3 | O=C1Nc2ncccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)O1 | 10.1016/j.bmcl.2009.09.066 | ||
| 44593545 | 185233 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 474 | 3 | 3 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL466192 | 185233 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 474 | 3 | 3 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2 | 10.1016/j.bmcl.2008.10.106 | ||
| 44562984 | 192821 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 419 | 3 | 3 | 5 | 1.3 | Cc1ccc2[nH]c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c2c1 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL487077 | 192821 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 419 | 3 | 3 | 5 | 1.3 | Cc1ccc2[nH]c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c2c1 | 10.1016/j.bmcl.2008.10.019 | ||
| 44563091 | 199319 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 462 | 5 | 3 | 7 | -0.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(CC(N)=O)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL521076 | 199319 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 462 | 5 | 3 | 7 | -0.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(CC(N)=O)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 59555245 | 111931 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 555 | 7 | 1 | 5 | 4.7 | O=C(CC1SC(c2ccccc2)N(CCc2ccccn2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114469 | 111931 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 555 | 7 | 1 | 5 | 4.7 | O=C(CC1SC(c2ccccc2)N(CCc2ccccn2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 11330650 | 168716 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 577 | 4 | 2 | 7 | 4.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3cnccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL415453 | 168716 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 577 | 4 | 2 | 7 | 4.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3cnccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 59554947 | 111949 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2[C@@H]2S[C@@H](CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114487 | 111949 | 0 | None | - | 1 | Human | 4.9 | pIC50 | = | 4.9 | Functional | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2[C@@H]2S[C@@H](CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 11215502 | 172914 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 594 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ccc(F)cc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL426142 | 172914 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 594 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ccc(F)cc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 11342207 | 148317 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 577 | 4 | 2 | 7 | 4.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ccncc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL384723 | 148317 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 577 | 4 | 2 | 7 | 4.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ccncc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 11707040 | 87853 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 602 | 5 | 2 | 6 | 5.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccccc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL215499 | 87853 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 602 | 5 | 2 | 6 | 5.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccccc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 44563162 | 181356 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 488 | 3 | 3 | 7 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n4c5c(cccc53)NC(=O)CCC4)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL455674 | 181356 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 488 | 3 | 3 | 7 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n4c5c(cccc53)NC(=O)CCC4)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 44593445 | 198308 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 518 | 5 | 2 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL519421 | 198308 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 518 | 5 | 2 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.019 | ||
| 11215412 | 81164 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 585 | 6 | 3 | 4 | 6.4 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cccc(-c3ccccc3)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024600 | 81164 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 585 | 6 | 3 | 4 | 6.4 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cccc(-c3ccccc3)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 11397560 | 96483 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 484 | 3 | 3 | 5 | 2.4 | O=C1NC[C@H](c2cccc(F)c2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL237661 | 96483 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 484 | 3 | 3 | 5 | 2.4 | O=C1NC[C@H](c2cccc(F)c2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 46885135 | 14808 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 468 | 2 | 2 | 7 | 1.4 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(Cn4c(=O)n5c6c(cccc64)NC(=O)C5)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1090848 | 14808 | 0 | None | - | 1 | Human | 7.9 | pIC50 | = | 7.9 | Functional | ChEMBL | 468 | 2 | 2 | 7 | 1.4 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(Cn4c(=O)n5c6c(cccc64)NC(=O)C5)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| 44563052 | 192814 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 490 | 5 | 3 | 7 | 0.6 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(N)=O | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL487068 | 192814 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 490 | 5 | 3 | 7 | 0.6 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(N)=O | 10.1016/j.bmcl.2008.10.019 | ||
| 44420286 | 91030 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 406 | 3 | 2 | 6 | 1.3 | CN1C(=O)NC(=O)C12Cc1ccc(NC(=O)Cn3c(=O)oc4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL221160 | 91030 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 406 | 3 | 2 | 6 | 1.3 | CN1C(=O)NC(=O)C12Cc1ccc(NC(=O)Cn3c(=O)oc4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| 44455153 | 104243 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 460 | 3 | 3 | 7 | 2.7 | Cn1cc(-c2cccc(O)c2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL270175 | 104243 | 0 | None | - | 1 | Human | 6.9 | pIC50 | = | 6.9 | Functional | ChEMBL | 460 | 3 | 3 | 7 | 2.7 | Cn1cc(-c2cccc(O)c2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 11849024 | 162062 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 502 | 4 | 3 | 7 | 2.7 | O=C(Nc1cc(-c2ccn[nH]2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL402887 | 162062 | 0 | None | - | 1 | Human | 5.9 | pIC50 | = | 5.9 | Functional | ChEMBL | 502 | 4 | 3 | 7 | 2.7 | O=C(Nc1cc(-c2ccn[nH]2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| 54582784 | 68265 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 564 | 6 | 3 | 7 | 3.6 | CNCCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770564 | 68265 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 564 | 6 | 3 | 7 | 3.6 | CNCCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 23656920 | 95923 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 528 | 5 | 3 | 6 | 2.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCO)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL236590 | 95923 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 528 | 5 | 3 | 6 | 2.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCO)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 11284233 | 96662 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 548 | 5 | 2 | 5 | 3.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL237849 | 96662 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 548 | 5 | 2 | 5 | 3.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 44562982 | 192820 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 423 | 3 | 3 | 5 | 1.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4cc(F)ccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL487076 | 192820 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 423 | 3 | 3 | 5 | 1.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4cc(F)ccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 44563091 | 199319 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 462 | 5 | 3 | 7 | -0.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(CC(N)=O)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL521076 | 199319 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 462 | 5 | 3 | 7 | -0.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(CC(N)=O)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 44563050 | 193426 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 505 | 5 | 2 | 8 | 1.3 | COC(=O)Cn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2cc(C)cc(C)c21 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL488082 | 193426 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 505 | 5 | 2 | 8 | 1.3 | COC(=O)Cn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2cc(C)cc(C)c21 | 10.1016/j.bmcl.2008.10.019 | ||
| 23656918 | 98569 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NCC(c2ccccc2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL241118 | 98569 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NCC(c2ccccc2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 122238743 | 167538 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 487 | 3 | 2 | 5 | 4.1 | O=C(NC1CC(c2ccccc2)Cc2cccnc21)c1cnc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| CHEMBL4114031 | 167538 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 487 | 3 | 2 | 5 | 4.1 | O=C(NC1CC(c2ccccc2)Cc2cccnc21)c1cnc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| 44563026 | 193422 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 435 | 4 | 3 | 6 | 1.0 | COc1ccc2[nH]c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c2c1 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL488065 | 193422 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 435 | 4 | 3 | 6 | 1.0 | COc1ccc2[nH]c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c2c1 | 10.1016/j.bmcl.2008.10.019 | ||
| 59554867 | 111987 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 492 | 5 | 1 | 4 | 4.5 | CC(C)N1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114681 | 111987 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 492 | 5 | 1 | 4 | 4.5 | CC(C)N1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| 11848755 | 102154 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 474 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2cc(NC(=O)N3CCC(n4c(=O)[nH]c5ncccc54)CC3)c(=O)n(C)c2)cc1 | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL256802 | 102154 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 474 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2cc(NC(=O)N3CCC(n4c(=O)[nH]c5ncccc54)CC3)c(=O)n(C)c2)cc1 | 10.1016/j.bmcl.2007.11.042 | ||
| 11519899 | 148265 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 584 | 5 | 2 | 8 | 3.5 | COC(=O)c1cn(C2CCN(C(=O)N[C@@H]3N=C(c4ccccc4)c4ccccc4N(CC(F)(F)F)C3=O)CC2)c(O)n1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL384408 | 148265 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 584 | 5 | 2 | 8 | 3.5 | COC(=O)c1cn(C2CCN(C(=O)N[C@@H]3N=C(c4ccccc4)c4ccccc4N(CC(F)(F)F)C3=O)CC2)c(O)n1 | 10.1016/j.bmcl.2006.07.044 | ||
| 11365194 | 147513 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 576 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL381798 | 147513 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 576 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 23656922 | 175635 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 555 | 6 | 2 | 6 | 2.7 | CN(C)CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| CHEMBL438120 | 175635 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 555 | 6 | 2 | 6 | 2.7 | CN(C)CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| 59555260 | 111937 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 619 | 7 | 1 | 6 | 5.3 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCOCC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114475 | 111937 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 619 | 7 | 1 | 6 | 5.3 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCOCC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 44570536 | 190652 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 474 | 3 | 2 | 5 | 1.7 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)CN3C(=O)C4(CCOCC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL480999 | 190652 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 474 | 3 | 2 | 5 | 1.7 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)CN3C(=O)C4(CCOCC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| 11848908 | 102220 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 524 | 6 | 2 | 7 | 3.3 | COCCn1cc(-c2cccc(F)c2F)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL257094 | 102220 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 524 | 6 | 2 | 7 | 3.3 | COCCn1cc(-c2cccc(F)c2F)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 59555152 | 111935 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 570 | 6 | 1 | 4 | 5.8 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1c(F)cccc1F | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114473 | 111935 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 570 | 6 | 1 | 4 | 5.8 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1c(F)cccc1F | 10.1016/j.bmcl.2013.12.089 | ||
| 11848855 | 104364 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 504 | 6 | 3 | 8 | 2.8 | COCCn1cc(-c2ccc(O)cc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL270796 | 104364 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 504 | 6 | 3 | 8 | 2.8 | COCCn1cc(-c2ccc(O)cc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 44420240 | 90250 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 475 | 4 | 2 | 7 | 1.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCOC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL220101 | 90250 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 475 | 4 | 2 | 7 | 1.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCOC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| 11785754 | 81151 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 522 | 6 | 2 | 4 | 5.3 | Cc1ccc(C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)Cc2cc(C)c3[nH]ncc3c2)nc1 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024587 | 81151 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 522 | 6 | 2 | 4 | 5.3 | Cc1ccc(C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)Cc2cc(C)c3[nH]ncc3c2)nc1 | 10.1016/j.bmcl.2012.02.065 | ||
| 11849025 | 102260 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 548 | 4 | 2 | 6 | 4.3 | O=C(Nc1cc(-c2cccc(F)c2F)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL257252 | 102260 | 0 | None | - | 1 | Human | 7.8 | pIC50 | = | 7.8 | Functional | ChEMBL | 548 | 4 | 2 | 6 | 4.3 | O=C(Nc1cc(-c2cccc(F)c2F)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| 59554953 | 111932 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 552 | 6 | 1 | 4 | 5.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1F | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114470 | 111932 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 552 | 6 | 1 | 4 | 5.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1F | 10.1016/j.bmcl.2013.12.089 | ||
| 44420231 | 143821 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 517 | 4 | 2 | 6 | 2.7 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4cc(F)cc(F)c4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL374666 | 143821 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 517 | 4 | 2 | 6 | 2.7 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4cc(F)cc(F)c4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| 23656749 | 98355 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 454 | 3 | 3 | 6 | 2.2 | O=C1NCC(c2ccsc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL240686 | 98355 | 0 | None | - | 1 | Human | 5.8 | pIC50 | = | 5.8 | Functional | ChEMBL | 454 | 3 | 3 | 6 | 2.2 | O=C1NCC(c2ccsc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 11261842 | 87838 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 591 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3ncccc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL215424 | 87838 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 591 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3ncccc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 44455080 | 102403 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 434 | 3 | 2 | 8 | 2.3 | Cn1cc(C2C=CN=N2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL257902 | 102403 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 434 | 3 | 2 | 8 | 2.3 | Cn1cc(C2C=CN=N2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 11848965 | 173478 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 530 | 4 | 2 | 6 | 4.1 | O=C(Nc1cc(-c2ccccc2F)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL428247 | 173478 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 530 | 4 | 2 | 6 | 4.1 | O=C(Nc1cc(-c2ccccc2F)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| 11691938 | 68259 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 507 | 3 | 2 | 6 | 3.9 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2ccnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770558 | 68259 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 507 | 3 | 2 | 6 | 3.9 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2ccnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 59555331 | 111950 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 646 | 7 | 1 | 6 | 5.3 | CN1CCN(c2ccccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114488 | 111950 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 646 | 7 | 1 | 6 | 5.3 | CN1CCN(c2ccccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 59555277 | 111934 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 570 | 6 | 1 | 4 | 5.8 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccc(F)cc1F | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114472 | 111934 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 570 | 6 | 1 | 4 | 5.8 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccc(F)cc1F | 10.1016/j.bmcl.2013.12.089 | ||
| 72194610 | 159370 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 503 | 3 | 2 | 6 | 3.6 | O=C(NC1COC(c2ccccc2)Cc2cccnc21)c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| CHEMBL3971889 | 159370 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 503 | 3 | 2 | 6 | 3.6 | O=C(NC1COC(c2ccccc2)Cc2cccnc21)c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| 11650307 | 87293 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 632 | 6 | 2 | 7 | 5.4 | COc1ccc(-c2cn(C3CCN(C(=O)N[C@@H]4N=C(c5ccccc5)c5ccccc5N(CC(F)(F)F)C4=O)CC3)c(O)n2)cc1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL214800 | 87293 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 632 | 6 | 2 | 7 | 5.4 | COc1ccc(-c2cn(C3CCN(C(=O)N[C@@H]4N=C(c5ccccc5)c5ccccc5N(CC(F)(F)F)C4=O)CC3)c(O)n2)cc1 | 10.1016/j.bmcl.2006.07.044 | ||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 11706981 | 68281 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 590 | 3 | 2 | 6 | 5.5 | O=C1Nc2ncccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)Cn4c(CC(F)(F)F)cnc43)CC2)O1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770720 | 68281 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 590 | 3 | 2 | 6 | 5.5 | O=C1Nc2ncccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)Cn4c(CC(F)(F)F)cnc43)CC2)O1 | 10.1016/j.bmcl.2010.12.054 | ||
| 59555031 | 111956 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 678 | 8 | 1 | 6 | 5.8 | CCN1CCN(c2c(F)cccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114494 | 111956 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 678 | 8 | 1 | 6 | 5.8 | CCN1CCN(c2c(F)cccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 21102037 | 80567 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 556 | 6 | 2 | 4 | 4.7 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(C)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018511 | 80567 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 556 | 6 | 2 | 4 | 4.7 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(C)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| 11364735 | 96484 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 542 | 6 | 2 | 6 | 2.8 | COCCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| CHEMBL237662 | 96484 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 542 | 6 | 2 | 6 | 2.8 | COCCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| 11753021 | 96485 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 538 | 5 | 2 | 5 | 3.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC2CC2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL237663 | 96485 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 538 | 5 | 2 | 5 | 3.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC2CC2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 11387595 | 153760 | 1 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 575 | 5 | 2 | 6 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(Cc2ccccn2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL392635 | 153760 | 1 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 575 | 5 | 2 | 6 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(Cc2ccccn2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 11432931 | 168691 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 558 | 6 | 2 | 6 | 3.5 | CSCCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| CHEMBL415263 | 168691 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 558 | 6 | 2 | 6 | 3.5 | CSCCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| 11192602 | 153763 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 590 | 6 | 2 | 7 | 2.2 | CS(=O)(=O)CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| CHEMBL392636 | 153763 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 590 | 6 | 2 | 7 | 2.2 | CS(=O)(=O)CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| 45267476 | 203063 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 463 | 3 | 3 | 5 | 3.2 | O=C(Cn1cc2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL562069 | 203063 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 463 | 3 | 3 | 5 | 3.2 | O=C(Cn1cc2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2009.09.066 | ||
| 11387141 | 81166 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 540 | 6 | 3 | 6 | 4.7 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(CO)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024602 | 81166 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 540 | 6 | 3 | 6 | 4.7 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(CO)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1021/jm500364u | ||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1021/jm500364u | ||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1021/jm070668p | ||
| 46885243 | 15100 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 467 | 2 | 2 | 5 | 2.9 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(CN4CC5(C)CC(=O)Nc6cccc4c65)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1092838 | 15100 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Functional | ChEMBL | 467 | 2 | 2 | 5 | 2.9 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(CN4CC5(C)CC(=O)Nc6cccc4c65)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| 54584803 | 68282 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 575 | 3 | 2 | 6 | 4.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)nnc21)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770721 | 68282 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 575 | 3 | 2 | 6 | 4.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)nnc21)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 25227362 | 180512 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 460 | 3 | 3 | 7 | 0.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n4c5c(cccc53)NC(=O)C4)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL453643 | 180512 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 460 | 3 | 3 | 7 | 0.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n4c5c(cccc53)NC(=O)C4)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 54582783 | 68257 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 548 | 4 | 2 | 7 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(C3CC3)nnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770556 | 68257 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 548 | 4 | 2 | 7 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(C3CC3)nnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2009.06.057 | ||
| 23582940 | 203381 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 465 | 3 | 3 | 5 | 3.0 | O=C(CN1CC2CC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL564088 | 203381 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 465 | 3 | 3 | 5 | 3.0 | O=C(CN1CC2CC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| 25227362 | 180512 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 460 | 3 | 3 | 7 | 0.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n4c5c(cccc53)NC(=O)C4)cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL453643 | 180512 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 460 | 3 | 3 | 7 | 0.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n4c5c(cccc53)NC(=O)C4)cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| 44593545 | 185233 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 474 | 3 | 3 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL466192 | 185233 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 474 | 3 | 3 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2 | 10.1016/j.bmcl.2008.10.106 | ||
| 46885183 | 15110 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 488 | 2 | 2 | 7 | 2.7 | O=C1Cn2c(=O)n(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)Nc4ncccc43)c3cccc(c32)N1 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1092882 | 15110 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 488 | 2 | 2 | 7 | 2.7 | O=C1Cn2c(=O)n(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)Nc4ncccc43)c3cccc(c32)N1 | 10.1016/j.bmcl.2010.02.086 | ||
| 44570614 | 184380 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 525 | 4 | 2 | 7 | 3.9 | O=C(Cn1c(=O)n(C2CCSCC2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL464078 | 184380 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 525 | 4 | 2 | 7 | 3.9 | O=C(Cn1c(=O)n(C2CCSCC2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| 11541560 | 68267 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 583 | 4 | 2 | 6 | 5.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(-c3ccccc3)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770566 | 68267 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 583 | 4 | 2 | 6 | 5.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(-c3ccccc3)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 54580803 | 68258 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 589 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770557 | 68258 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 589 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 54584803 | 68282 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 575 | 3 | 2 | 6 | 4.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)nnc21)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770721 | 68282 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 575 | 3 | 2 | 6 | 4.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)nnc21)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 11692628 | 204404 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 567 | 3 | 2 | 5 | 4.3 | O=C1Nc2ncccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)O1 | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL570746 | 204404 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Functional | ChEMBL | 567 | 3 | 2 | 5 | 4.3 | O=C1Nc2ncccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)O1 | 10.1016/j.bmcl.2009.09.066 | ||
| 54583843 | 68287 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 594 | 5 | 2 | 7 | 5.7 | CCOC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770726 | 68287 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 594 | 5 | 2 | 7 | 5.7 | CCOC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 72191699 | 99104 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 551 | 5 | 3 | 7 | 4.3 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2ncc3n2CCNC3)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430163 | 99104 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 551 | 5 | 3 | 7 | 4.3 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2ncc3n2CCNC3)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 11443894 | 81074 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 526 | 6 | 2 | 4 | 5.2 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024171 | 81074 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 526 | 6 | 2 | 4 | 5.2 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 44562897 | 185845 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4c(Cl)cccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL471530 | 185845 | 0 | None | - | 1 | Human | 5.7 | pIC50 | = | 5.7 | Functional | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4c(Cl)cccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 11848964 | 101979 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 512 | 4 | 2 | 6 | 4.0 | O=C(Nc1cc(-c2ccccc2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL255966 | 101979 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 512 | 4 | 2 | 6 | 4.0 | O=C(Nc1cc(-c2ccccc2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| 44563162 | 181356 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 488 | 3 | 3 | 7 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n4c5c(cccc53)NC(=O)CCC4)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL455674 | 181356 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 488 | 3 | 3 | 7 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n4c5c(cccc53)NC(=O)CCC4)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 11753021 | 96485 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 538 | 5 | 2 | 5 | 3.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC2CC2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL237663 | 96485 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 538 | 5 | 2 | 5 | 3.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC2CC2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 45487036 | 204405 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 541 | 4 | 2 | 4 | 3.6 | Cc1cc(C2CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)c(=O)[nH]n1 | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL570748 | 204405 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 541 | 4 | 2 | 4 | 3.6 | Cc1cc(C2CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)c(=O)[nH]n1 | 10.1016/j.bmcl.2009.09.066 | ||
| 59555008 | 111933 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 570 | 6 | 1 | 4 | 5.8 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1cccc(F)c1F | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114471 | 111933 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 570 | 6 | 1 | 4 | 5.8 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1cccc(F)c1F | 10.1016/j.bmcl.2013.12.089 | ||
| 11397560 | 96483 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 484 | 3 | 3 | 5 | 2.4 | O=C1NC[C@H](c2cccc(F)c2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL237661 | 96483 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 484 | 3 | 3 | 5 | 2.4 | O=C1NC[C@H](c2cccc(F)c2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 11225752 | 96486 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 498 | 3 | 2 | 5 | 2.8 | CN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| CHEMBL237664 | 96486 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 498 | 3 | 2 | 5 | 2.8 | CN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| 72194611 | 155943 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 487 | 3 | 2 | 5 | 4.1 | O=C(NC1CC(c2ccccc2)Cc2cccnc21)c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| CHEMBL3943580 | 155943 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 487 | 3 | 2 | 5 | 4.1 | O=C(NC1CC(c2ccccc2)Cc2cccnc21)c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| 117992045 | 160923 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 555 | 3 | 2 | 5 | 5.2 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)[C@@H](F)c2cccnc21)c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| CHEMBL3985425 | 160923 | 0 | None | - | 1 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 555 | 3 | 2 | 5 | 5.2 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)[C@@H](F)c2cccnc21)c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| 44416514 | 162514 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 654 | 5 | 2 | 8 | 4.3 | CS(=O)(=O)c1ccc2c(c1)nc(O)n2C1CCN(C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(F)(F)F)C2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL405544 | 162514 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 654 | 5 | 2 | 8 | 4.3 | CS(=O)(=O)c1ccc2c(c1)nc(O)n2C1CCN(C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(F)(F)F)C2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 44563161 | 180513 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 474 | 3 | 2 | 7 | 0.4 | CN1C(=O)Cn2c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c3cccc1c32 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL453644 | 180513 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 474 | 3 | 2 | 7 | 0.4 | CN1C(=O)Cn2c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c3cccc1c32 | 10.1016/j.bmcl.2008.10.019 | ||
| 11454113 | 152530 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NC[C@H](c2cccc(F)c2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL391660 | 152530 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NC[C@H](c2cccc(F)c2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 46905052 | 17190 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 488 | 3 | 2 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2C | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL1162991 | 17190 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 488 | 3 | 2 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2C | 10.1016/j.bmcl.2008.10.106 | ||
| 44570499 | 199175 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 505 | 4 | 2 | 7 | 2.5 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCSCC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL520778 | 199175 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 505 | 4 | 2 | 7 | 2.5 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCSCC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| 11157626 | 173215 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 591 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3ccncc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL427743 | 173215 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Functional | ChEMBL | 591 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3ccncc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 44562895 | 185821 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 433 | 3 | 3 | 5 | 1.6 | Cc1cc(C)c2[nH]c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c2c1 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL471358 | 185821 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 433 | 3 | 3 | 5 | 1.6 | Cc1cc(C)c2[nH]c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c2c1 | 10.1016/j.bmcl.2008.10.019 | ||
| 44593445 | 198308 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 518 | 5 | 2 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL519421 | 198308 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 518 | 5 | 2 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.019 | ||
| 23656920 | 95923 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 528 | 5 | 3 | 6 | 2.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCO)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL236590 | 95923 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 528 | 5 | 3 | 6 | 2.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCO)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 45271754 | 201833 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 479 | 3 | 3 | 5 | 3.3 | O=C(CN1CC2CCC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL549503 | 201833 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 479 | 3 | 3 | 5 | 3.3 | O=C(CN1CC2CCC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| 11548734 | 205203 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 577 | 4 | 2 | 4 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)N=C(c1ccccc1)NC2=O | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL577110 | 205203 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 577 | 4 | 2 | 4 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)N=C(c1ccccc1)NC2=O | 10.1016/j.bmcl.2009.09.066 | ||
| 44593445 | 198308 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 518 | 5 | 2 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL519421 | 198308 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 518 | 5 | 2 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.106 | ||
| 58901616 | 80555 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 612 | 7 | 3 | 6 | 4.2 | O=C(C[C@H](Nc1ccc2[nH]ncc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018499 | 80555 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 612 | 7 | 3 | 6 | 4.2 | O=C(C[C@H](Nc1ccc2[nH]ncc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | ||
| 44563160 | 181354 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 518 | 7 | 2 | 7 | 1.3 | CN(C)C(=O)CCCn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2ccccc21 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL455670 | 181354 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 518 | 7 | 2 | 7 | 1.3 | CN(C)C(=O)CCCn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2ccccc21 | 10.1016/j.bmcl.2008.10.019 | ||
| 23582940 | 203381 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 465 | 3 | 3 | 5 | 3.0 | O=C(CN1CC2CC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL564088 | 203381 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 465 | 3 | 3 | 5 | 3.0 | O=C(CN1CC2CC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| 44570614 | 184380 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 525 | 4 | 2 | 7 | 3.9 | O=C(Cn1c(=O)n(C2CCSCC2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL464078 | 184380 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 525 | 4 | 2 | 7 | 3.9 | O=C(Cn1c(=O)n(C2CCSCC2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| 44420236 | 144367 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 488 | 4 | 2 | 8 | 1.9 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4nccs4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL375533 | 144367 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 488 | 4 | 2 | 8 | 1.9 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4nccs4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| 76310534 | 111927 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 520 | 5 | 1 | 4 | 5.1 | CC(C)(C)CN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114465 | 111927 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 520 | 5 | 1 | 4 | 5.1 | CC(C)(C)CN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| 23656918 | 98569 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NCC(c2ccccc2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL241118 | 98569 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NCC(c2ccccc2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 11454113 | 152530 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NC[C@H](c2cccc(F)c2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL391660 | 152530 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NC[C@H](c2cccc(F)c2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 44563090 | 193427 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 510 | 4 | 2 | 7 | 2.5 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2-c1ccccn1 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL488083 | 193427 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 510 | 4 | 2 | 7 | 2.5 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2-c1ccccn1 | 10.1016/j.bmcl.2008.10.019 | ||
| 11678239 | 68261 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 537 | 4 | 3 | 7 | 3.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2cc(CO)nc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770560 | 68261 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 537 | 4 | 3 | 7 | 3.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2cc(CO)nc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 44562937 | 185872 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 435 | 4 | 3 | 6 | 1.0 | COc1cccc2c1[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL471704 | 185872 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 435 | 4 | 3 | 6 | 1.0 | COc1cccc2c1[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | ||
| 44570499 | 199175 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 505 | 4 | 2 | 7 | 2.5 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCSCC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL520778 | 199175 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 505 | 4 | 2 | 7 | 2.5 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCSCC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| 44570580 | 184226 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 495 | 4 | 2 | 7 | 2.8 | O=C(Cn1c(=O)n(C2CCOC2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL463880 | 184226 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 495 | 4 | 2 | 7 | 2.8 | O=C(Cn1c(=O)n(C2CCOC2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| 11692140 | 68262 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 521 | 3 | 2 | 6 | 4.2 | Cc1cn2c(n1)[C@H](NC(=O)N1CCC(n3c(=O)[nH]c4ncccc43)CC1)CC[C@@H](c1cccc(F)c1F)C2 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770561 | 68262 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 521 | 3 | 2 | 6 | 4.2 | Cc1cn2c(n1)[C@H](NC(=O)N1CCC(n3c(=O)[nH]c4ncccc43)CC1)CC[C@@H](c1cccc(F)c1F)C2 | 10.1016/j.bmcl.2010.12.054 | ||
| 11238250 | 80884 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 554 | 6 | 3 | 6 | 4.9 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(C(=O)O)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2022595 | 80884 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 554 | 6 | 3 | 6 | 4.9 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(C(=O)O)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 44563123 | 195665 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 490 | 5 | 2 | 7 | 0.5 | CN(C)C(=O)Cn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2ccccc21 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL507339 | 195665 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 490 | 5 | 2 | 7 | 0.5 | CN(C)C(=O)Cn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2ccccc21 | 10.1016/j.bmcl.2008.10.019 | ||
| 11848855 | 104364 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 504 | 6 | 3 | 8 | 2.8 | COCCn1cc(-c2ccc(O)cc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL270796 | 104364 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 504 | 6 | 3 | 8 | 2.8 | COCCn1cc(-c2ccc(O)cc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 11849020 | 101822 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 528 | 4 | 3 | 7 | 3.7 | O=C(Nc1cc(-c2ccc(O)cc2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL255136 | 101822 | 0 | None | - | 1 | Human | 6.6 | pIC50 | = | 6.6 | Functional | ChEMBL | 528 | 4 | 3 | 7 | 3.7 | O=C(Nc1cc(-c2ccc(O)cc2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| 11444589 | 86564 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 578 | 4 | 2 | 8 | 3.7 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3nccnc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL211931 | 86564 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 578 | 4 | 2 | 8 | 3.7 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3nccnc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 117992192 | 154039 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 552 | 3 | 3 | 6 | 4.2 | N[C@@H]1c2cccnc2[C@@H](NC(=O)c2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)CC[C@H]1c1cccc(F)c1F | nan | ||
| CHEMBL3928622 | 154039 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 552 | 3 | 3 | 6 | 4.2 | N[C@@H]1c2cccnc2[C@@H](NC(=O)c2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)CC[C@H]1c1cccc(F)c1F | nan | ||
| 10340456 | 90284 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 392 | 3 | 3 | 6 | 0.9 | O=C(Cn1c(=O)oc2ccccc21)Nc1ccc2c(c1)CC1(C2)NC(=O)NC1=O | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL220336 | 90284 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 392 | 3 | 3 | 6 | 0.9 | O=C(Cn1c(=O)oc2ccccc21)Nc1ccc2c(c1)CC1(C2)NC(=O)NC1=O | 10.1016/j.bmcl.2006.09.045 | ||
| 59555236 | 111928 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 5.3 | O=C(CC1SC(c2ccccc2)N(c2ccccc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114466 | 111928 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 526 | 5 | 1 | 4 | 5.3 | O=C(CC1SC(c2ccccc2)N(c2ccccc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 59554895 | 111952 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 664 | 7 | 1 | 6 | 5.4 | CN1CCN(c2c(F)cccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114490 | 111952 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 664 | 7 | 1 | 6 | 5.4 | CN1CCN(c2c(F)cccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 11192602 | 153763 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 590 | 6 | 2 | 7 | 2.2 | CS(=O)(=O)CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| CHEMBL392636 | 153763 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 590 | 6 | 2 | 7 | 2.2 | CS(=O)(=O)CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| 11364735 | 96484 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 542 | 6 | 2 | 6 | 2.8 | COCCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| CHEMBL237662 | 96484 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 542 | 6 | 2 | 6 | 2.8 | COCCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| 23657089 | 153758 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 597 | 6 | 2 | 7 | 2.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCN2CCOCC2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL392634 | 153758 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 597 | 6 | 2 | 7 | 2.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCN2CCOCC2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 45271754 | 201833 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 479 | 3 | 3 | 5 | 3.3 | O=C(CN1CC2CCC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL549503 | 201833 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 479 | 3 | 3 | 5 | 3.3 | O=C(CN1CC2CCC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| 11606400 | 68269 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 549 | 4 | 2 | 6 | 5.0 | CC(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770568 | 68269 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 549 | 4 | 2 | 6 | 5.0 | CC(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 11584808 | 204467 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 551 | 3 | 2 | 4 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL571203 | 204467 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 551 | 3 | 2 | 4 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2009.09.066 | ||
| 11341430 | 81165 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 523 | 5 | 3 | 4 | 5.1 | Cc1cccc(C(Cc2cc(C)c3[nH]ncc3c2)NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)n1 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024601 | 81165 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Functional | ChEMBL | 523 | 5 | 3 | 4 | 5.1 | Cc1cccc(C(Cc2cc(C)c3[nH]ncc3c2)NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)n1 | 10.1016/j.bmcl.2012.02.065 | ||
| 11721278 | 68268 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 590 | 4 | 2 | 8 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(-c3nccs3)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770567 | 68268 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 590 | 4 | 2 | 8 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(-c3nccs3)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 44563160 | 181354 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 518 | 7 | 2 | 7 | 1.3 | CN(C)C(=O)CCCn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2ccccc21 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL455670 | 181354 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 518 | 7 | 2 | 7 | 1.3 | CN(C)C(=O)CCCn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2ccccc21 | 10.1016/j.bmcl.2008.10.019 | ||
| 11249157 | 81155 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 505 | 6 | 2 | 4 | 5.2 | Cc1cc(CC(CC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024591 | 81155 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 505 | 6 | 2 | 4 | 5.2 | Cc1cc(CC(CC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 11375693 | 96661 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 512 | 4 | 2 | 5 | 3.1 | CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| CHEMBL237848 | 96661 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 512 | 4 | 2 | 5 | 3.1 | CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| 58864453 | 80470 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 626 | 8 | 3 | 6 | 3.9 | O=C(C[C@H](NCc1ccc2[nH]ncc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018356 | 80470 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 626 | 8 | 3 | 6 | 3.9 | O=C(C[C@H](NCc1ccc2[nH]ncc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | ||
| 11848963 | 162213 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 484 | 5 | 2 | 6 | 3.8 | O=C(Nc1cc(-c2ccccc2)cn(CC2CC2)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL403765 | 162213 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 484 | 5 | 2 | 6 | 3.8 | O=C(Nc1cc(-c2ccccc2)cn(CC2CC2)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| 44455457 | 101985 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 478 | 6 | 3 | 8 | 1.8 | COCCn1cc(-c2ccn[nH]2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL255998 | 101985 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 478 | 6 | 3 | 8 | 1.8 | COCCn1cc(-c2ccn[nH]2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 44563161 | 180513 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 474 | 3 | 2 | 7 | 0.4 | CN1C(=O)Cn2c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c3cccc1c32 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL453644 | 180513 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 474 | 3 | 2 | 7 | 0.4 | CN1C(=O)Cn2c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c3cccc1c32 | 10.1016/j.bmcl.2008.10.019 | ||
| 46905052 | 17190 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 488 | 3 | 2 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2C | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL1162991 | 17190 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 488 | 3 | 2 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2C | 10.1016/j.bmcl.2008.10.106 | ||
| 11497403 | 172855 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 528 | 4 | 2 | 4 | 3.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2CCNC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL425807 | 172855 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 528 | 4 | 2 | 4 | 3.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2CCNC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 70685453 | 80550 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 651 | 8 | 2 | 7 | 4.9 | O=C(C[C@H](Nc1ccc(Cl)cc1[N+](=O)[O-])C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018494 | 80550 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 651 | 8 | 2 | 7 | 4.9 | O=C(C[C@H](Nc1ccc(Cl)cc1[N+](=O)[O-])C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | ||
| 59554855 | 111918 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 506 | 7 | 1 | 4 | 4.9 | CCCCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114456 | 111918 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 506 | 7 | 1 | 4 | 4.9 | CCCCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| 10483468 | 80571 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 586 | 6 | 2 | 6 | 3.5 | O=C(CC(Cc1ccc2[nH]ncc2c1)C(=O)N1CCC2(CC1)OCCO2)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018515 | 80571 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 586 | 6 | 2 | 6 | 3.5 | O=C(CC(Cc1ccc2[nH]ncc2c1)C(=O)N1CCC2(CC1)OCCO2)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | ||
| 11699891 | 68260 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 589 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2cc(CC(F)(F)F)nc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770559 | 68260 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 589 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2cc(CC(F)(F)F)nc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 59554993 | 111951 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 632 | 7 | 2 | 6 | 4.9 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCNCC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114489 | 111951 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 632 | 7 | 2 | 6 | 4.9 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCNCC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 46885184 | 15111 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 482 | 2 | 1 | 7 | 1.4 | CN1C(=O)Cn2c(=O)n(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)NC(=O)N3C)c3cccc1c32 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1092883 | 15111 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 482 | 2 | 1 | 7 | 1.4 | CN1C(=O)Cn2c(=O)n(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)NC(=O)N3C)c3cccc1c32 | 10.1016/j.bmcl.2010.02.086 | ||
| 11848750 | 102362 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 450 | 3 | 2 | 7 | 3.0 | Cn1cc(-c2ccsc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL257731 | 102362 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 450 | 3 | 2 | 7 | 3.0 | Cn1cc(-c2ccsc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 10453991 | 144658 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 406 | 3 | 3 | 6 | 1.3 | O=C(Cn1c(=O)oc2ccccc21)Nc1ccc2c(c1)CCC1(C2)NC(=O)NC1=O | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL376263 | 144658 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | 406 | 3 | 3 | 6 | 1.3 | O=C(Cn1c(=O)oc2ccccc21)Nc1ccc2c(c1)CCC1(C2)NC(=O)NC1=O | 10.1016/j.bmcl.2006.09.045 | ||
| 44455043 | 102501 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 462 | 3 | 2 | 6 | 3.1 | Cn1cc(-c2cccc(F)c2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL258329 | 102501 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 462 | 3 | 2 | 6 | 3.1 | Cn1cc(-c2cccc(F)c2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 11410749 | 172608 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 590 | 4 | 2 | 4 | 5.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL424864 | 172608 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 590 | 4 | 2 | 4 | 5.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 11541560 | 68267 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 583 | 4 | 2 | 6 | 5.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(-c3ccccc3)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770566 | 68267 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 583 | 4 | 2 | 6 | 5.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(-c3ccccc3)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 24756768 | 80568 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 529 | 5 | 2 | 5 | 4.5 | Cc1cc(CC(CC(=O)N2CCC3(CC2)OC(=O)Nc2ccccc23)C(=O)N2CCCCC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018512 | 80568 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 529 | 5 | 2 | 5 | 4.5 | Cc1cc(CC(CC(=O)N2CCC3(CC2)OC(=O)Nc2ccccc23)C(=O)N2CCCCC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| 23656919 | 161524 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NCC(c2cccc(F)c2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL400020 | 161524 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NCC(c2cccc(F)c2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 11168000 | 160962 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 502 | 5 | 2 | 5 | 3.3 | O=C(N[C@@H]1CC[C@@H](c2ccccc2)CN(CC2CC2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL398575 | 160962 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 502 | 5 | 2 | 5 | 3.3 | O=C(N[C@@H]1CC[C@@H](c2ccccc2)CN(CC2CC2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 11848968 | 101980 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 518 | 4 | 2 | 7 | 4.0 | O=C(Nc1cc(-c2ccsc2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL255967 | 101980 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 518 | 4 | 2 | 7 | 4.0 | O=C(Nc1cc(-c2ccsc2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| 44570579 | 197610 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 503 | 4 | 2 | 8 | 2.6 | O=C(Cn1c(=O)n(-c2ccncn2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL518422 | 197610 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 503 | 4 | 2 | 8 | 2.6 | O=C(Cn1c(=O)n(-c2ccncn2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| 44420287 | 90214 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 406 | 3 | 2 | 6 | 1.3 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)oc4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL219782 | 90214 | 0 | None | - | 1 | Human | 6.5 | pIC50 | = | 6.5 | Functional | ChEMBL | 406 | 3 | 2 | 6 | 1.3 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)oc4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL2371945 | 216936 | 0 | None | - | 1 | Human | 5.5 | pIC50 | = | 5.5 | Functional | ChEMBL | None | None | None | CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](N)Cc1ccccc1)C(C)C)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)NN(C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm061343w | ||||
| 59554975 | 111945 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 662 | 9 | 2 | 7 | 4.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCN(CCO)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114483 | 111945 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 662 | 9 | 2 | 7 | 4.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCN(CCO)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 11849147 | 102028 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 509 | 6 | 2 | 5 | 5.0 | O=C(Nc1cc(-c2ccccc2)cn(CC2CC2)c1=O)N1CCC(n2cc(-c3ccccc3)[nH]c2=O)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL256203 | 102028 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 509 | 6 | 2 | 5 | 5.0 | O=C(Nc1cc(-c2ccccc2)cn(CC2CC2)c1=O)N1CCC(n2cc(-c3ccccc3)[nH]c2=O)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| 44417050 | 148287 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 626 | 4 | 2 | 6 | 6.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3c4ccccc4ccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL384539 | 148287 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 626 | 4 | 2 | 6 | 6.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3c4ccccc4ccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 11541725 | 148164 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 603 | 5 | 2 | 7 | 4.8 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccccn3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL383872 | 148164 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 603 | 5 | 2 | 7 | 4.8 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccccn3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 45273525 | 202465 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 479 | 3 | 2 | 5 | 3.0 | CN1C(=O)C[C@@H]2CN(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)Nc4ncccc43)c3cccc1c32 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL556703 | 202465 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 479 | 3 | 2 | 5 | 3.0 | CN1C(=O)C[C@@H]2CN(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)Nc4ncccc43)c3cccc1c32 | 10.1016/j.bmcl.2009.06.057 | ||
| 45269221 | 203436 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 493 | 3 | 3 | 5 | 3.7 | O=C(CN1CC2CCCC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL564466 | 203436 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 493 | 3 | 3 | 5 | 3.7 | O=C(CN1CC2CCCC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| 44563028 | 201345 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 447 | 3 | 2 | 6 | 1.6 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2C | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL530116 | 201345 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 447 | 3 | 2 | 6 | 1.6 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2C | 10.1016/j.bmcl.2008.10.019 | ||
| 59554982 | 111919 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 506 | 6 | 1 | 4 | 4.7 | CC(C)CN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114457 | 111919 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 506 | 6 | 1 | 4 | 4.7 | CC(C)CN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| 24853374 | 111985 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 520 | 7 | 1 | 4 | 5.1 | CC(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114679 | 111985 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 520 | 7 | 1 | 4 | 5.1 | CC(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| 44416436 | 87330 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 594 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3c(F)cccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL214873 | 87330 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 594 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3c(F)cccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 11168000 | 160962 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 502 | 5 | 2 | 5 | 3.3 | O=C(N[C@@H]1CC[C@@H](c2ccccc2)CN(CC2CC2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL398575 | 160962 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 502 | 5 | 2 | 5 | 3.3 | O=C(N[C@@H]1CC[C@@H](c2ccccc2)CN(CC2CC2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 23656752 | 98520 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 414 | 3 | 3 | 5 | 1.6 | CC(C)C1CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C(=O)NC1 | 10.1021/jm070668p | ||
| CHEMBL240904 | 98520 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 414 | 3 | 3 | 5 | 1.6 | CC(C)C1CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C(=O)NC1 | 10.1021/jm070668p | ||
| 72194744 | 159691 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 537 | 3 | 2 | 5 | 4.7 | O=C(N[C@H]1CC[C@H](c2cccc(F)c2F)Cc2cccnc21)c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| CHEMBL3974762 | 159691 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 537 | 3 | 2 | 5 | 4.7 | O=C(N[C@H]1CC[C@H](c2cccc(F)c2F)Cc2cccnc21)c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| 44420691 | 168682 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 1196 | 28 | 12 | 14 | -1.7 | CC(C)[C@H](NC(=O)N(CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm061343w | ||
| CHEMBL415186 | 168682 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 1196 | 28 | 12 | 14 | -1.7 | CC(C)[C@H](NC(=O)N(CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm061343w | ||
| 44570615 | 184381 | 9 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 494 | 3 | 2 | 5 | 3.1 | O=C(CN1C(=O)C2(CCOCC2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL464079 | 184381 | 9 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 494 | 3 | 2 | 5 | 3.1 | O=C(CN1C(=O)C2(CCOCC2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| 44420241 | 143490 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 488 | 4 | 2 | 8 | 1.9 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4cnsc4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL374064 | 143490 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 488 | 4 | 2 | 8 | 1.9 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4cnsc4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| 44455457 | 101985 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 478 | 6 | 3 | 8 | 1.8 | COCCn1cc(-c2ccn[nH]2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL255998 | 101985 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 478 | 6 | 3 | 8 | 1.8 | COCCn1cc(-c2ccn[nH]2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 54587752 | 68277 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 574 | 3 | 2 | 5 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)cnc21)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770716 | 68277 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 574 | 3 | 2 | 5 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)cnc21)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 6918509 | 83817 | 41 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL207197 | 83817 | 41 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 59555074 | 111946 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2[C@H]2S[C@@H](CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114484 | 111946 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2[C@H]2S[C@@H](CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 23657089 | 153758 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 597 | 6 | 2 | 7 | 2.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCN2CCOCC2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL392634 | 153758 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 597 | 6 | 2 | 7 | 2.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCN2CCOCC2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 54581838 | 68263 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 521 | 3 | 2 | 6 | 4.2 | Cc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770562 | 68263 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 521 | 3 | 2 | 6 | 4.2 | Cc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 54583775 | 68266 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 578 | 4 | 2 | 7 | 3.6 | CN(C)C(=O)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770565 | 68266 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 578 | 4 | 2 | 7 | 3.6 | CN(C)C(=O)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 11295168 | 81156 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 509 | 5 | 3 | 4 | 4.8 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024592 | 81156 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 509 | 5 | 3 | 4 | 4.8 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 45271740 | 203325 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 477 | 3 | 2 | 5 | 3.2 | CN1C(=O)Cc2cn(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)Nc4ncccc43)c3cccc1c23 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL563727 | 203325 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 477 | 3 | 2 | 5 | 3.2 | CN1C(=O)Cc2cn(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)Nc4ncccc43)c3cccc1c23 | 10.1016/j.bmcl.2009.06.057 | ||
| 46885242 | 15099 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 473 | 2 | 2 | 5 | 4.1 | O=C1CC2CN(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)Nc4ncccc43)c3cccc(c32)N1 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1092837 | 15099 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 473 | 2 | 2 | 5 | 4.1 | O=C1CC2CN(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)Nc4ncccc43)c3cccc(c32)N1 | 10.1016/j.bmcl.2010.02.086 | ||
| 44570616 | 196993 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 538 | 5 | 2 | 7 | 2.5 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)Nc3ncccc31)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL517467 | 196993 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 538 | 5 | 2 | 7 | 2.5 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)Nc3ncccc31)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.106 | ||
| 54581897 | 68279 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 536 | 4 | 2 | 6 | 4.0 | COCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770718 | 68279 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 536 | 4 | 2 | 6 | 4.0 | COCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 72194609 | 167441 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 537 | 3 | 2 | 5 | 4.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cc2cccnc21)c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| CHEMBL4113356 | 167441 | 0 | None | - | 1 | Human | 8.4 | pIC50 | = | 8.4 | Functional | ChEMBL | 537 | 3 | 2 | 5 | 4.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cc2cccnc21)c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| 70695974 | 80576 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 643 | 7 | 2 | 5 | 5.1 | Cc1cc(C[C@H](CC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018520 | 80576 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 643 | 7 | 2 | 5 | 5.1 | Cc1cc(C[C@H](CC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| 46885134 | 14807 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 446 | 2 | 1 | 4 | 4.1 | O=C1CCc2ccccc2N1Cc1ccc2cc3c(cc2n1)C[C@@]1(C3)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1090847 | 14807 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 446 | 2 | 1 | 4 | 4.1 | O=C1CCc2ccccc2N1Cc1ccc2cc3c(cc2n1)C[C@@]1(C3)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2010.02.086 | ||
| 11398863 | 81161 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 560 | 5 | 2 | 5 | 6.4 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc3ccccc3n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024597 | 81161 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 560 | 5 | 2 | 5 | 6.4 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc3ccccc3n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 11273798 | 99113 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 654 | 5 | 4 | 4 | 5.6 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nc(Br)c(Br)[nH]2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430172 | 99113 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 654 | 5 | 4 | 4 | 5.6 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nc(Br)c(Br)[nH]2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 11785573 | 99125 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 512 | 5 | 3 | 5 | 4.1 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2C)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430184 | 99125 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 512 | 5 | 3 | 5 | 4.1 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2nccn2C)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 24853164 | 111938 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2C2SC(CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114476 | 111938 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2C2SC(CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 44563089 | 192939 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 491 | 5 | 3 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)O | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL487240 | 192939 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 491 | 5 | 3 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)O | 10.1016/j.bmcl.2008.10.019 | ||
| 44562897 | 185845 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4c(Cl)cccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL471530 | 185845 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4c(Cl)cccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 44570578 | 185189 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 502 | 4 | 2 | 7 | 3.2 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL465934 | 185189 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 502 | 4 | 2 | 7 | 3.2 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| 44563090 | 193427 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 510 | 4 | 2 | 7 | 2.5 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2-c1ccccn1 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL488083 | 193427 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 510 | 4 | 2 | 7 | 2.5 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2-c1ccccn1 | 10.1016/j.bmcl.2008.10.019 | ||
| 44563126 | 195712 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 490 | 7 | 3 | 7 | 0.7 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(CCCC(N)=O)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL508016 | 195712 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 490 | 7 | 3 | 7 | 0.7 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(CCCC(N)=O)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 46885186 | 14805 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 453 | 2 | 2 | 5 | 2.7 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(CN4CC5CC(=O)Nc6cccc4c65)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1090841 | 14805 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 453 | 2 | 2 | 5 | 2.7 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(CN4CC5CC(=O)Nc6cccc4c65)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| 11786529 | 146309 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 578 | 4 | 2 | 8 | 3.7 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncncc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL379548 | 146309 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 578 | 4 | 2 | 8 | 3.7 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncncc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 44420227 | 90207 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 467 | 4 | 3 | 6 | 2.1 | O=C(Cn1c(=O)n(-c2ccccc2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)NC(=O)NC1=O | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL219721 | 90207 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 467 | 4 | 3 | 6 | 2.1 | O=C(Cn1c(=O)n(-c2ccccc2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)NC(=O)NC1=O | 10.1016/j.bmcl.2006.09.045 | ||
| 44417049 | 175598 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 686 | 6 | 2 | 7 | 6.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccc(OC(F)(F)F)cc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL437718 | 175598 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 686 | 6 | 2 | 7 | 6.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccc(OC(F)(F)F)cc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 44563089 | 192939 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 491 | 5 | 3 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)O | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL487240 | 192939 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 491 | 5 | 3 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)O | 10.1016/j.bmcl.2008.10.019 | ||
| 59554936 | 111939 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 633 | 7 | 2 | 6 | 5.5 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCC(O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114477 | 111939 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 633 | 7 | 2 | 6 | 5.5 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCC(O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 59555036 | 111944 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 674 | 10 | 1 | 6 | 6.4 | CCCCN1CCN(c2ccccc2C2SC(CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114482 | 111944 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 674 | 10 | 1 | 6 | 6.4 | CCCCN1CCN(c2ccccc2C2SC(CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 11432505 | 204412 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 527 | 4 | 2 | 4 | 3.3 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(c2ccn[nH]c2=O)CC1 | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL570793 | 204412 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 527 | 4 | 2 | 4 | 3.3 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(c2ccn[nH]c2=O)CC1 | 10.1016/j.bmcl.2009.09.066 | ||
| 46885245 | 14619 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 481 | 3 | 2 | 5 | 3.3 | CCC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@@]1(C4)C(=O)NC(=O)N1C)C2 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1089772 | 14619 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Functional | ChEMBL | 481 | 3 | 2 | 5 | 3.3 | CCC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@@]1(C4)C(=O)NC(=O)N1C)C2 | 10.1016/j.bmcl.2010.02.086 | ||
| 44562937 | 185872 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 435 | 4 | 3 | 6 | 1.0 | COc1cccc2c1[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL471704 | 185872 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 435 | 4 | 3 | 6 | 1.0 | COc1cccc2c1[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | ||
| 44416437 | 148572 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 610 | 4 | 2 | 6 | 5.5 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3c(Cl)cccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL386204 | 148572 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 610 | 4 | 2 | 6 | 5.5 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3c(Cl)cccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 11423175 | 143756 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 949 | 23 | 11 | 12 | -2.7 | CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1)[C@@H](C)O)C(=O)NCC(=O)N1CCCN1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm061343w | ||
| CHEMBL374579 | 143756 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 949 | 23 | 11 | 12 | -2.7 | CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1)[C@@H](C)O)C(=O)NCC(=O)N1CCCN1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm061343w | ||
| 59555102 | 111986 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 464 | 4 | 1 | 4 | 3.7 | CN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114680 | 111986 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 464 | 4 | 1 | 4 | 3.7 | CN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| 11549001 | 148657 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 616 | 6 | 2 | 6 | 5.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(Cc3ccccc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL386701 | 148657 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 616 | 6 | 2 | 6 | 5.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(Cc3ccccc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 44563027 | 193423 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4cccc(Cl)c43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL488066 | 193423 | 0 | None | - | 1 | Human | 6.4 | pIC50 | = | 6.4 | Functional | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4cccc(Cl)c43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 44562983 | 198166 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 435 | 4 | 3 | 6 | 1.0 | COc1ccc2c(c1)[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL519242 | 198166 | 0 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Functional | ChEMBL | 435 | 4 | 3 | 6 | 1.0 | COc1ccc2c(c1)[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | ||
| 59555274 | 111921 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 532 | 5 | 1 | 4 | 4.6 | O=C(CC1SC(c2ccccc2)N(CC(F)(F)F)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114459 | 111921 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 532 | 5 | 1 | 4 | 4.6 | O=C(CC1SC(c2ccccc2)N(CC(F)(F)F)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 11628731 | 87168 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 620 | 5 | 2 | 6 | 5.5 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3cccc(F)c3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL214507 | 87168 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 620 | 5 | 2 | 6 | 5.5 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3cccc(F)c3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 76332330 | 111983 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 706 | 7 | 1 | 6 | 6.6 | CC(C)(C)CCN1C(=O)[C@H](CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)S[C@H]1c1cccc(F)c1N1CCN(C(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114677 | 111983 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 706 | 7 | 1 | 6 | 6.6 | CC(C)(C)CCN1C(=O)[C@H](CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)S[C@H]1c1cccc(F)c1N1CCN(C(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 58864250 | 80548 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 608 | 7 | 2 | 7 | 3.8 | O=C(C[C@H](Nc1cc(Cl)ncn1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018492 | 80548 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 608 | 7 | 2 | 7 | 3.8 | O=C(C[C@H](Nc1cc(Cl)ncn1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | ||
| 122238743 | 167538 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 487 | 3 | 2 | 5 | 4.1 | O=C(NC1CC(c2ccccc2)Cc2cccnc21)c1cnc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| CHEMBL4114031 | 167538 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 487 | 3 | 2 | 5 | 4.1 | O=C(NC1CC(c2ccccc2)Cc2cccnc21)c1cnc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| 44455078 | 102363 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 462 | 3 | 2 | 6 | 3.1 | Cn1cc(-c2ccccc2F)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL257732 | 102363 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 462 | 3 | 2 | 6 | 3.1 | Cn1cc(-c2ccccc2F)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 72194610 | 159370 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 503 | 3 | 2 | 6 | 3.6 | O=C(NC1COC(c2ccccc2)Cc2cccnc21)c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| CHEMBL3971889 | 159370 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 503 | 3 | 2 | 6 | 3.6 | O=C(NC1COC(c2ccccc2)Cc2cccnc21)c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| 59554876 | 111923 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 549 | 9 | 1 | 5 | 4.4 | CCN(CC)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114461 | 111923 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 549 | 9 | 1 | 5 | 4.4 | CCN(CC)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| 11421827 | 164383 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 577 | 4 | 2 | 6 | 3.8 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL408093 | 164383 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 577 | 4 | 2 | 6 | 3.8 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 11421827 | 164383 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 577 | 4 | 2 | 6 | 3.8 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL408093 | 164383 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 577 | 4 | 2 | 6 | 3.8 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2008.10.106 | ||
| 44562939 | 185874 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4cc(Cl)ccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL471706 | 185874 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4cc(Cl)ccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 11495985 | 102445 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 444 | 3 | 2 | 6 | 3.0 | Cn1cc(-c2ccccc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL258070 | 102445 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 444 | 3 | 2 | 6 | 3.0 | Cn1cc(-c2ccccc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 11284233 | 96662 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 548 | 5 | 2 | 5 | 3.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL237849 | 96662 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 548 | 5 | 2 | 5 | 3.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 11752904 | 154129 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 530 | 5 | 2 | 5 | 3.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCF)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL392937 | 154129 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 530 | 5 | 2 | 5 | 3.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCF)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 11180666 | 153872 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 574 | 6 | 2 | 6 | 2.5 | C[S+]([O-])CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| CHEMBL392730 | 153872 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 574 | 6 | 2 | 6 | 2.5 | C[S+]([O-])CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| 11512928 | 148449 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 632 | 6 | 2 | 7 | 5.4 | COc1cccc(-c2cn(C3CCN(C(=O)N[C@@H]4N=C(c5ccccc5)c5ccccc5N(CC(F)(F)F)C4=O)CC3)c(O)n2)c1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL385454 | 148449 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 632 | 6 | 2 | 7 | 5.4 | COc1cccc(-c2cn(C3CCN(C(=O)N[C@@H]4N=C(c5ccccc5)c5ccccc5N(CC(F)(F)F)C4=O)CC3)c(O)n2)c1 | 10.1016/j.bmcl.2006.07.044 | ||
| 44570580 | 184226 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 495 | 4 | 2 | 7 | 2.8 | O=C(Cn1c(=O)n(C2CCOC2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL463880 | 184226 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 495 | 4 | 2 | 7 | 2.8 | O=C(Cn1c(=O)n(C2CCOC2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| 23582940 | 203381 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 465 | 3 | 3 | 5 | 3.0 | O=C(CN1CC2CC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL564088 | 203381 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 465 | 3 | 3 | 5 | 3.0 | O=C(CN1CC2CC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| 25227362 | 180512 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 460 | 3 | 3 | 7 | 0.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n4c5c(cccc53)NC(=O)C4)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL453643 | 180512 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 460 | 3 | 3 | 7 | 0.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n4c5c(cccc53)NC(=O)C4)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 25227362 | 180512 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 460 | 3 | 3 | 7 | 0.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n4c5c(cccc53)NC(=O)C4)cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL453643 | 180512 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 460 | 3 | 3 | 7 | 0.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n4c5c(cccc53)NC(=O)C4)cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| 44593545 | 185233 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 474 | 3 | 3 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL466192 | 185233 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 474 | 3 | 3 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2 | 10.1016/j.bmcl.2008.10.106 | ||
| 44563050 | 193426 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 505 | 5 | 2 | 8 | 1.3 | COC(=O)Cn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2cc(C)cc(C)c21 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL488082 | 193426 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 505 | 5 | 2 | 8 | 1.3 | COC(=O)Cn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2cc(C)cc(C)c21 | 10.1016/j.bmcl.2008.10.019 | ||
| 44570615 | 184381 | 9 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 494 | 3 | 2 | 5 | 3.1 | O=C(CN1C(=O)C2(CCOCC2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL464079 | 184381 | 9 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 494 | 3 | 2 | 5 | 3.1 | O=C(CN1C(=O)C2(CCOCC2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| 10438558 | 80565 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 600 | 6 | 2 | 6 | 3.8 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC3(CC2)OCCO3)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018509 | 80565 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 600 | 6 | 2 | 6 | 3.8 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC3(CC2)OCCO3)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| 46885133 | 14806 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 426 | 2 | 1 | 4 | 2.7 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(CN4C(=O)CCc5ccccc54)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1090846 | 14806 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 426 | 2 | 1 | 4 | 2.7 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(CN4C(=O)CCc5ccccc54)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| 44420260 | 90255 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 483 | 4 | 2 | 8 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4cncnc4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL220146 | 90255 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 483 | 4 | 2 | 8 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4cncnc4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| 44420250 | 143706 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 551 | 4 | 2 | 8 | 2.3 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4nccc(C(F)(F)F)n4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL374251 | 143706 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 551 | 4 | 2 | 8 | 2.3 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4nccc(C(F)(F)F)n4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| 59555111 | 111916 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 490 | 5 | 1 | 4 | 4.2 | O=C(CC1SC(c2ccccc2)N(C2CC2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114454 | 111916 | 0 | None | - | 1 | Human | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 490 | 5 | 1 | 4 | 4.2 | O=C(CC1SC(c2ccccc2)N(C2CC2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 59555024 | 111926 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 534 | 6 | 1 | 5 | 4.2 | O=C(CC1SC(c2ccccc2)N(CC2CCCO2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114464 | 111926 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 534 | 6 | 1 | 5 | 4.2 | O=C(CC1SC(c2ccccc2)N(CC2CCCO2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 11453687 | 174233 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 448 | 3 | 3 | 5 | 2.1 | O=C1NC[C@H](c2ccccc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL429803 | 174233 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 448 | 3 | 3 | 5 | 2.1 | O=C1NC[C@H](c2ccccc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 24756769 | 80570 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 598 | 6 | 2 | 6 | 4.7 | O=C1Nc2ccccc2C2(CCN(C(=O)CC(Cc3ccc4[nH]ncc4c3)C(=O)N3CCC(N4CCCCC4)CC3)CC2)O1 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018514 | 80570 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 598 | 6 | 2 | 6 | 4.7 | O=C1Nc2ccccc2C2(CCN(C(=O)CC(Cc3ccc4[nH]ncc4c3)C(=O)N3CCC(N4CCCCC4)CC3)CC2)O1 | 10.1016/j.bmcl.2012.02.066 | ||
| 44420235 | 91549 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL223156 | 91549 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 45273525 | 202465 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 479 | 3 | 2 | 5 | 3.0 | CN1C(=O)C[C@@H]2CN(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)Nc4ncccc43)c3cccc1c32 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL556703 | 202465 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 479 | 3 | 2 | 5 | 3.0 | CN1C(=O)C[C@@H]2CN(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)Nc4ncccc43)c3cccc1c32 | 10.1016/j.bmcl.2009.06.057 | ||
| 44420235 | 91549 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL223156 | 91549 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| 44420235 | 91549 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL223156 | 91549 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| 9978597 | 148420 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 405 | 3 | 3 | 6 | 0.7 | Cn1c(=O)n(CC(=O)Nc2ccc3c(c2)CC2(C3)NC(=O)NC2=O)c2ccccc21 | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL385322 | 148420 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 405 | 3 | 3 | 6 | 0.7 | Cn1c(=O)n(CC(=O)Nc2ccc3c(c2)CC2(C3)NC(=O)NC2=O)c2ccccc21 | 10.1016/j.bmcl.2006.09.045 | ||
| 44420245 | 90779 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 512 | 5 | 2 | 8 | 1.9 | COc1cccc(-n2c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c3ccccc32)n1 | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL220715 | 90779 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 512 | 5 | 2 | 8 | 1.9 | COc1cccc(-n2c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c3ccccc32)n1 | 10.1016/j.bmcl.2006.09.045 | ||
| 44454954 | 102160 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 494 | 6 | 2 | 8 | 3.1 | COCCn1cc(-c2ccsc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL256813 | 102160 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 494 | 6 | 2 | 8 | 3.1 | COCCn1cc(-c2ccsc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 45487057 | 204587 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 516 | 3 | 2 | 4 | 2.4 | O=C1CC2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)C(=O)N1 | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL572114 | 204587 | 0 | None | - | 1 | Human | 7.3 | pIC50 | = | 7.3 | Functional | ChEMBL | 516 | 3 | 2 | 4 | 2.4 | O=C1CC2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)C(=O)N1 | 10.1016/j.bmcl.2009.09.066 | ||
| 11849024 | 162062 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 502 | 4 | 3 | 7 | 2.7 | O=C(Nc1cc(-c2ccn[nH]2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL402887 | 162062 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 502 | 4 | 3 | 7 | 2.7 | O=C(Nc1cc(-c2ccn[nH]2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| 44455041 | 177376 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 480 | 3 | 2 | 6 | 3.2 | Cn1cc(-c2cccc(F)c2F)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL445069 | 177376 | 0 | None | - | 1 | Human | 6.3 | pIC50 | = | 6.3 | Functional | ChEMBL | 480 | 3 | 2 | 6 | 3.2 | Cn1cc(-c2cccc(F)c2F)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 44570536 | 190652 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 474 | 3 | 2 | 5 | 1.7 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)CN3C(=O)C4(CCOCC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL480999 | 190652 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 474 | 3 | 2 | 5 | 1.7 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)CN3C(=O)C4(CCOCC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| 72194743 | 166842 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 555 | 3 | 2 | 5 | 5.2 | O=C(N[C@H]1CC[C@H](c2cccc(F)c2F)[C@H](F)c2cccnc21)c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| CHEMBL4108361 | 166842 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 555 | 3 | 2 | 5 | 5.2 | O=C(N[C@H]1CC[C@H](c2cccc(F)c2F)[C@H](F)c2cccnc21)c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| 44420693 | 175256 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 1196 | 28 | 12 | 14 | -1.4 | CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](N)Cc1ccccc1)C(C)C)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NN(Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm061343w | ||
| CHEMBL435149 | 175256 | 0 | None | - | 1 | Human | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 1196 | 28 | 12 | 14 | -1.4 | CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](N)Cc1ccccc1)C(C)C)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)NN(Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm061343w | ||
| CHEMBL438426 | 220550 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | None | None | None | CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)N(N)Cc1ccccc1)C(C)C)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm061343w | ||||
| 44562896 | 185822 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 419 | 3 | 3 | 5 | 1.3 | Cc1cccc2c1[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL471359 | 185822 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 419 | 3 | 3 | 5 | 1.3 | Cc1cccc2c1[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | ||
| 58864479 | 80554 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 611 | 7 | 3 | 5 | 4.9 | O=C(C[C@H](Nc1ccc2[nH]ccc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018498 | 80554 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 611 | 7 | 3 | 5 | 4.9 | O=C(C[C@H](Nc1ccc2[nH]ccc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | ||
| 44562938 | 185873 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 419 | 3 | 3 | 5 | 1.3 | Cc1ccc2c(c1)[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL471705 | 185873 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 419 | 3 | 3 | 5 | 1.3 | Cc1ccc2c(c1)[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | ||
| 11753024 | 81152 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 538 | 7 | 3 | 5 | 4.5 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc(CO)cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024588 | 81152 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 538 | 7 | 3 | 5 | 4.5 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc(CO)cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 11375693 | 96661 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 512 | 4 | 2 | 5 | 3.1 | CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| CHEMBL237848 | 96661 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 512 | 4 | 2 | 5 | 3.1 | CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| 23656921 | 96997 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 596 | 6 | 2 | 6 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCOC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL238276 | 96997 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 596 | 6 | 2 | 6 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCOC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 72194608 | 150957 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 552 | 3 | 3 | 6 | 4.2 | N[C@H]1c2cccnc2[C@H](NC(=O)c2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)CC[C@H]1c1cccc(F)c1F | nan | ||
| CHEMBL3904139 | 150957 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 552 | 3 | 3 | 6 | 4.2 | N[C@H]1c2cccnc2[C@H](NC(=O)c2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)CC[C@H]1c1cccc(F)c1F | nan | ||
| 45267481 | 203441 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 479 | 3 | 3 | 5 | 3.1 | CC12CC(=O)Nc3cccc(c31)N(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)Nc3ncccc31)C2 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL564487 | 203441 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 479 | 3 | 3 | 5 | 3.1 | CC12CC(=O)Nc3cccc(c31)N(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)Nc3ncccc31)C2 | 10.1016/j.bmcl.2009.06.057 | ||
| 46885243 | 15100 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 467 | 2 | 2 | 5 | 2.9 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(CN4CC5(C)CC(=O)Nc6cccc4c65)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1092838 | 15100 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 467 | 2 | 2 | 5 | 2.9 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(CN4CC5(C)CC(=O)Nc6cccc4c65)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| 11691938 | 68259 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 507 | 3 | 2 | 6 | 3.9 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2ccnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770558 | 68259 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 507 | 3 | 2 | 6 | 3.9 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2ccnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 21102038 | 80569 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 542 | 6 | 2 | 4 | 4.5 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCCCC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018513 | 80569 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 542 | 6 | 2 | 4 | 4.5 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCCCC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| 44562939 | 185874 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4cc(Cl)ccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL471706 | 185874 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4cc(Cl)ccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 59555157 | 111936 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 618 | 7 | 2 | 6 | 4.9 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCNCC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114474 | 111936 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 618 | 7 | 2 | 6 | 4.9 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCNCC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 11555955 | 204504 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 566 | 3 | 2 | 4 | 4.9 | O=C1Nc2ccccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)O1 | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL571459 | 204504 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 566 | 3 | 2 | 4 | 4.9 | O=C1Nc2ccccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)O1 | 10.1016/j.bmcl.2009.09.066 | ||
| 44420240 | 90250 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 475 | 4 | 2 | 7 | 1.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCOC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL220101 | 90250 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 475 | 4 | 2 | 7 | 1.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCOC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| 44420240 | 90250 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 475 | 4 | 2 | 7 | 1.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCOC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL220101 | 90250 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 475 | 4 | 2 | 7 | 1.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCOC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| 11456102 | 86820 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 591 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3cccnc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL212942 | 86820 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 591 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3cccnc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 59554885 | 111941 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 600 | 7 | 1 | 6 | 5.7 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1-n1cccn1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114479 | 111941 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 600 | 7 | 1 | 6 | 5.7 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1-n1cccn1 | 10.1016/j.bmcl.2013.12.089 | ||
| 23656752 | 98520 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 414 | 3 | 3 | 5 | 1.6 | CC(C)C1CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C(=O)NC1 | 10.1021/jm070668p | ||
| CHEMBL240904 | 98520 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 414 | 3 | 3 | 5 | 1.6 | CC(C)C1CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C(=O)NC1 | 10.1021/jm070668p | ||
| 11330786 | 145166 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 591 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3cnccc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL377252 | 145166 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 591 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3cnccc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 44562985 | 192941 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccc(Cl)cc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL487244 | 192941 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccc(Cl)cc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 11721278 | 68268 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 590 | 4 | 2 | 8 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(-c3nccs3)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770567 | 68268 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 590 | 4 | 2 | 8 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(-c3nccs3)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 44420256 | 91722 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 483 | 4 | 2 | 8 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4cnccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL223756 | 91722 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 483 | 4 | 2 | 8 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4cnccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| 44420261 | 144061 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 523 | 4 | 2 | 8 | 0.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCS(=O)(=O)C4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL375224 | 144061 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 523 | 4 | 2 | 8 | 0.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCS(=O)(=O)C4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| 59555066 | 111955 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 664 | 7 | 1 | 6 | 5.4 | CN1CCN(c2cccc(F)c2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114493 | 111955 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 664 | 7 | 1 | 6 | 5.4 | CN1CCN(c2cccc(F)c2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 11351794 | 97755 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NC[C@H](c2ccccc2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL239630 | 97755 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NC[C@H](c2ccccc2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 117992083 | 151673 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 552 | 3 | 3 | 6 | 4.2 | N[C@H]1c2cccnc2[C@@H](NC(=O)c2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)CC[C@H]1c1cccc(F)c1F | nan | ||
| CHEMBL3910081 | 151673 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 552 | 3 | 3 | 6 | 4.2 | N[C@H]1c2cccnc2[C@@H](NC(=O)c2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)CC[C@H]1c1cccc(F)c1F | nan | ||
| 11849023 | 101933 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 513 | 4 | 2 | 7 | 3.4 | O=C(Nc1cc(-c2cccnc2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL255755 | 101933 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 513 | 4 | 2 | 7 | 3.4 | O=C(Nc1cc(-c2cccnc2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| 11848800 | 162051 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 488 | 6 | 2 | 7 | 3.1 | COCCn1cc(-c2ccccc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL402844 | 162051 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 488 | 6 | 2 | 7 | 3.1 | COCCn1cc(-c2ccccc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 45271740 | 203325 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 477 | 3 | 2 | 5 | 3.2 | CN1C(=O)Cc2cn(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)Nc4ncccc43)c3cccc1c23 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL563727 | 203325 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 477 | 3 | 2 | 5 | 3.2 | CN1C(=O)Cc2cn(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)Nc4ncccc43)c3cccc1c23 | 10.1016/j.bmcl.2009.06.057 | ||
| 44420692 | 168531 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 1196 | 28 | 13 | 14 | -1.7 | CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](N)Cc1ccccc1)C(C)C)[C@@H](C)O)C(=O)NNC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm061343w | ||
| CHEMBL413872 | 168531 | 0 | None | - | 1 | Human | 7.2 | pIC50 | = | 7.2 | Functional | ChEMBL | 1196 | 28 | 13 | 14 | -1.7 | CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](N)Cc1ccccc1)C(C)C)[C@@H](C)O)C(=O)NNC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm061343w | ||
| 11692206 | 86984 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 526 | 4 | 2 | 6 | 3.7 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2ccnc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL213670 | 86984 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 526 | 4 | 2 | 6 | 3.7 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2ccnc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 10340395 | 91770 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 391 | 3 | 4 | 5 | 0.6 | O=C(Cn1c(=O)[nH]c2ccccc21)Nc1ccc2c(c1)CC1(C2)NC(=O)NC1=O | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL223805 | 91770 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 391 | 3 | 4 | 5 | 0.6 | O=C(Cn1c(=O)[nH]c2ccccc21)Nc1ccc2c(c1)CC1(C2)NC(=O)NC1=O | 10.1016/j.bmcl.2006.09.045 | ||
| 11599531 | 205225 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 578 | 4 | 2 | 3 | 4.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)CC(c1ccccc1)NC2=O | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL577320 | 205225 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 578 | 4 | 2 | 3 | 4.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)CC(c1ccccc1)NC2=O | 10.1016/j.bmcl.2009.09.066 | ||
| 11699891 | 68260 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 589 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2cc(CC(F)(F)F)nc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770559 | 68260 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 589 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2cc(CC(F)(F)F)nc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 45269221 | 203436 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 493 | 3 | 3 | 5 | 3.7 | O=C(CN1CC2CCCC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL564466 | 203436 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 493 | 3 | 3 | 5 | 3.7 | O=C(CN1CC2CCCC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| 46885245 | 14619 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 481 | 3 | 2 | 5 | 3.3 | CCC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@@]1(C4)C(=O)NC(=O)N1C)C2 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1089772 | 14619 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 481 | 3 | 2 | 5 | 3.3 | CCC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@@]1(C4)C(=O)NC(=O)N1C)C2 | 10.1016/j.bmcl.2010.02.086 | ||
| 46885186 | 14805 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 453 | 2 | 2 | 5 | 2.7 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(CN4CC5CC(=O)Nc6cccc4c65)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1090841 | 14805 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 453 | 2 | 2 | 5 | 2.7 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(CN4CC5CC(=O)Nc6cccc4c65)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| 54583775 | 68266 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 578 | 4 | 2 | 7 | 3.6 | CN(C)C(=O)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770565 | 68266 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 578 | 4 | 2 | 7 | 3.6 | CN(C)C(=O)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 11444574 | 99114 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 576 | 5 | 4 | 4 | 4.9 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ncc(Br)[nH]2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430173 | 99114 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 576 | 5 | 4 | 4 | 4.9 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ncc(Br)[nH]2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 54583774 | 68264 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 537 | 4 | 3 | 7 | 3.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CO)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770563 | 68264 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 537 | 4 | 3 | 7 | 3.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CO)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | ||
| 11453687 | 174233 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 448 | 3 | 3 | 5 | 2.1 | O=C1NC[C@H](c2ccccc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL429803 | 174233 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 448 | 3 | 3 | 5 | 2.1 | O=C1NC[C@H](c2ccccc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL376719 | 219034 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | None | None | None | CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm061343w | ||||
| 24853163 | 111925 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 532 | 5 | 1 | 4 | 5.4 | O=C(CC1SC(c2ccccc2)N(C2CCCCC2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114463 | 111925 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 532 | 5 | 1 | 4 | 5.4 | O=C(CC1SC(c2ccccc2)N(C2CCCCC2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 44416512 | 162513 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 620 | 5 | 3 | 7 | 4.6 | O=C(O)c1ccc2c(c1)nc(O)n2C1CCN(C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(F)(F)F)C2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL405543 | 162513 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 620 | 5 | 3 | 7 | 4.6 | O=C(O)c1ccc2c(c1)nc(O)n2C1CCN(C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(F)(F)F)C2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 44455153 | 104243 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 460 | 3 | 3 | 7 | 2.7 | Cn1cc(-c2cccc(O)c2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL270175 | 104243 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 460 | 3 | 3 | 7 | 2.7 | Cn1cc(-c2cccc(O)c2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 44563051 | 193454 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 519 | 5 | 2 | 8 | 1.8 | COC(=O)[C@H](C)n1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2cc(C)cc(C)c21 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL488255 | 193454 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 519 | 5 | 2 | 8 | 1.8 | COC(=O)[C@H](C)n1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2cc(C)cc(C)c21 | 10.1016/j.bmcl.2008.10.019 | ||
| 59554934 | 111954 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 664 | 7 | 1 | 6 | 5.4 | CN1CCN(c2ccc(F)cc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114492 | 111954 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 664 | 7 | 1 | 6 | 5.4 | CN1CCN(c2ccc(F)cc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 11421827 | 164383 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 577 | 4 | 2 | 6 | 3.8 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL408093 | 164383 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 577 | 4 | 2 | 6 | 3.8 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2008.10.106 | ||
| 11571094 | 148668 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 668 | 7 | 2 | 7 | 6.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccc(OC(F)F)cc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL386757 | 148668 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 668 | 7 | 2 | 7 | 6.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccc(OC(F)F)cc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 44570498 | 190819 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 483 | 4 | 2 | 8 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccncn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL482178 | 190819 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 483 | 4 | 2 | 8 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccncn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| 76310551 | 111984 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 662 | 9 | 2 | 4 | 6.1 | CC(C)CCN(Cc1cc(Br)c(O)c(Br)c1)C(=O)CCC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114678 | 111984 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 662 | 9 | 2 | 4 | 6.1 | CC(C)CCN(Cc1cc(Br)c(O)c(Br)c1)C(=O)CCC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 59554924 | 111929 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 558 | 6 | 1 | 4 | 5.4 | O=C(CC1SC(c2ccccc2)N(Cc2ccc(F)cc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114467 | 111929 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 558 | 6 | 1 | 4 | 5.4 | O=C(CC1SC(c2ccccc2)N(Cc2ccc(F)cc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 23656749 | 98355 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 454 | 3 | 3 | 6 | 2.2 | O=C1NCC(c2ccsc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL240686 | 98355 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 454 | 3 | 3 | 6 | 2.2 | O=C1NCC(c2ccsc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 44562936 | 185715 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 423 | 3 | 3 | 5 | 1.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4c(F)cccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL470321 | 185715 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 423 | 3 | 3 | 5 | 1.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4c(F)cccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 44563126 | 195712 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 490 | 7 | 3 | 7 | 0.7 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(CCCC(N)=O)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL508016 | 195712 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 490 | 7 | 3 | 7 | 0.7 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(CCCC(N)=O)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 59554857 | 111920 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 506 | 4 | 1 | 4 | 4.9 | CC(C)(C)N1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114458 | 111920 | 0 | None | - | 1 | Human | 5.1 | pIC50 | = | 5.1 | Functional | ChEMBL | 506 | 4 | 1 | 4 | 4.9 | CC(C)(C)N1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL223642 | 216224 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | None | None | None | CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1)[C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O | 10.1021/jm061343w | ||||
| 44420235 | 91549 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL223156 | 91549 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 44420235 | 91549 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL223156 | 91549 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| 44420235 | 91549 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL223156 | 91549 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | ||
| 44420235 | 91549 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| CHEMBL223156 | 91549 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | ||
| 72194611 | 155943 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 487 | 3 | 2 | 5 | 4.1 | O=C(NC1CC(c2ccccc2)Cc2cccnc21)c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| CHEMBL3943580 | 155943 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 487 | 3 | 2 | 5 | 4.1 | O=C(NC1CC(c2ccccc2)Cc2cccnc21)c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | nan | ||
| 44563025 | 199274 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 423 | 3 | 3 | 5 | 1.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccc(F)cc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL520905 | 199274 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 423 | 3 | 3 | 5 | 1.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccc(F)cc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | ||
| 11520022 | 87339 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 604 | 5 | 2 | 4 | 4.7 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2CC(c3ccccc3)NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL214904 | 87339 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 604 | 5 | 2 | 4 | 4.7 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2CC(c3ccccc3)NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 11555955 | 204504 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 566 | 3 | 2 | 4 | 4.9 | O=C1Nc2ccccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)O1 | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL571459 | 204504 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 566 | 3 | 2 | 4 | 4.9 | O=C1Nc2ccccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)O1 | 10.1016/j.bmcl.2009.09.066 | ||
| 11225752 | 96486 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 498 | 3 | 2 | 5 | 2.8 | CN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| CHEMBL237664 | 96486 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 498 | 3 | 2 | 5 | 2.8 | CN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| 11180666 | 153872 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 574 | 6 | 2 | 6 | 2.5 | C[S+]([O-])CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| CHEMBL392730 | 153872 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 574 | 6 | 2 | 6 | 2.5 | C[S+]([O-])CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| 11432931 | 168691 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 558 | 6 | 2 | 6 | 3.5 | CSCCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| CHEMBL415263 | 168691 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 558 | 6 | 2 | 6 | 3.5 | CSCCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| 23656922 | 175635 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 555 | 6 | 2 | 6 | 2.7 | CN(C)CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| CHEMBL438120 | 175635 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 555 | 6 | 2 | 6 | 2.7 | CN(C)CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | ||
| 23582940 | 203381 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 465 | 3 | 3 | 5 | 3.0 | O=C(CN1CC2CC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| CHEMBL564088 | 203381 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 465 | 3 | 3 | 5 | 3.0 | O=C(CN1CC2CC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | ||
| 11156698 | 81076 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 522 | 6 | 2 | 4 | 5.3 | Cc1cccnc1C(CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)Cc1cc(C)c2[nH]ncc2c1 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024173 | 81076 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 522 | 6 | 2 | 4 | 5.3 | Cc1cccnc1C(CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)Cc1cc(C)c2[nH]ncc2c1 | 10.1016/j.bmcl.2012.02.065 | ||
| 11520007 | 68278 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 600 | 3 | 2 | 5 | 5.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(C3(C(F)(F)F)CC3)cnc21)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770717 | 68278 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 600 | 3 | 2 | 5 | 5.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(C3(C(F)(F)F)CC3)cnc21)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | ||
| 44570578 | 185189 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 502 | 4 | 2 | 7 | 3.2 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| CHEMBL465934 | 185189 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 502 | 4 | 2 | 7 | 3.2 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | ||
| 11692140 | 68262 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 521 | 3 | 2 | 6 | 4.2 | Cc1cn2c(n1)[C@H](NC(=O)N1CCC(n3c(=O)[nH]c4ncccc43)CC1)CC[C@@H](c1cccc(F)c1F)C2 | 10.1016/j.bmcl.2010.12.054 | ||
| CHEMBL1770561 | 68262 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 521 | 3 | 2 | 6 | 4.2 | Cc1cn2c(n1)[C@H](NC(=O)N1CCC(n3c(=O)[nH]c4ncccc43)CC1)CC[C@@H](c1cccc(F)c1F)C2 | 10.1016/j.bmcl.2010.12.054 | ||
| 11432183 | 81073 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 508 | 6 | 2 | 4 | 5.0 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2024170 | 81073 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 508 | 6 | 2 | 4 | 5.0 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 24756767 | 80566 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 587 | 5 | 2 | 7 | 3.9 | Cc1cc(CC(CC(=O)N2CCC3(CC2)OC(=O)Nc2ccccc23)C(=O)N2CCC3(CC2)OCCO3)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018510 | 80566 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Functional | ChEMBL | 587 | 5 | 2 | 7 | 3.9 | Cc1cc(CC(CC(=O)N2CCC3(CC2)OC(=O)Nc2ccccc23)C(=O)N2CCC3(CC2)OCCO3)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | ||
| 59554942 | 111930 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 541 | 6 | 1 | 5 | 4.7 | O=C(CC1SC(c2ccccc2)N(Cc2cccnc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114468 | 111930 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 541 | 6 | 1 | 5 | 4.7 | O=C(CC1SC(c2ccccc2)N(Cc2cccnc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 11527287 | 87322 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 605 | 5 | 2 | 5 | 4.1 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2CC(c3ccncc3)NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL214829 | 87322 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 605 | 5 | 2 | 5 | 4.1 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2CC(c3ccncc3)NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | ||
| 46885134 | 14807 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 446 | 2 | 1 | 4 | 4.1 | O=C1CCc2ccccc2N1Cc1ccc2cc3c(cc2n1)C[C@@]1(C3)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1090847 | 14807 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 446 | 2 | 1 | 4 | 4.1 | O=C1CCc2ccccc2N1Cc1ccc2cc3c(cc2n1)C[C@@]1(C3)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2010.02.086 | ||
| 11849025 | 102260 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 548 | 4 | 2 | 6 | 4.3 | O=C(Nc1cc(-c2cccc(F)c2F)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL257252 | 102260 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 548 | 4 | 2 | 6 | 4.3 | O=C(Nc1cc(-c2cccc(F)c2F)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| 11848645 | 104286 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 460 | 3 | 3 | 7 | 2.7 | Cn1cc(-c2ccccc2O)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL270392 | 104286 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 460 | 3 | 3 | 7 | 2.7 | Cn1cc(-c2ccccc2O)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 59555055 | 111953 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 664 | 7 | 1 | 6 | 5.4 | CN1CCN(c2cc(F)ccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114491 | 111953 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 664 | 7 | 1 | 6 | 5.4 | CN1CCN(c2cc(F)ccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 59555326 | 111917 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 504 | 6 | 1 | 4 | 4.5 | O=C(CC1SC(c2ccccc2)N(CC2CC2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114455 | 111917 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 504 | 6 | 1 | 4 | 4.5 | O=C(CC1SC(c2ccccc2)N(CC2CC2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 11585317 | 87693 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 616 | 5 | 2 | 6 | 5.7 | Cc1ccc(-c2cn(C3CCN(C(=O)N[C@@H]4N=C(c5ccccc5)c5ccccc5N(CC(F)(F)F)C4=O)CC3)c(O)n2)cc1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL215325 | 87693 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 616 | 5 | 2 | 6 | 5.7 | Cc1ccc(-c2cn(C3CCN(C(=O)N[C@@H]4N=C(c5ccccc5)c5ccccc5N(CC(F)(F)F)C4=O)CC3)c(O)n2)cc1 | 10.1016/j.bmcl.2006.07.044 | ||
| 46885133 | 14806 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 426 | 2 | 1 | 4 | 2.7 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(CN4C(=O)CCc5ccccc54)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1090846 | 14806 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 426 | 2 | 1 | 4 | 2.7 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(CN4C(=O)CCc5ccccc54)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | ||
| 59555012 | 111940 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 600 | 7 | 1 | 6 | 5.7 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1-n1ccnc1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114478 | 111940 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 600 | 7 | 1 | 6 | 5.7 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1-n1ccnc1 | 10.1016/j.bmcl.2013.12.089 | ||
| 11548734 | 205203 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 577 | 4 | 2 | 4 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)N=C(c1ccccc1)NC2=O | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL577110 | 205203 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 577 | 4 | 2 | 4 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)N=C(c1ccccc1)NC2=O | 10.1016/j.bmcl.2009.09.066 | ||
| 44455080 | 102403 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 434 | 3 | 2 | 8 | 2.3 | Cn1cc(C2C=CN=N2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL257902 | 102403 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 434 | 3 | 2 | 8 | 2.3 | Cn1cc(C2C=CN=N2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 59555230 | 111942 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 611 | 7 | 1 | 5 | 6.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1-c1cccnc1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114480 | 111942 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 611 | 7 | 1 | 5 | 6.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1-c1cccnc1 | 10.1016/j.bmcl.2013.12.089 | ||
| 11848646 | 104285 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 460 | 3 | 3 | 7 | 2.7 | Cn1cc(-c2ccc(O)cc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL270390 | 104285 | 0 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 460 | 3 | 3 | 7 | 2.7 | Cn1cc(-c2ccc(O)cc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | ||
| 23656753 | 98568 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 462 | 4 | 3 | 5 | 2.2 | O=C1NCC(Cc2ccccc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| CHEMBL241117 | 98568 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 462 | 4 | 3 | 5 | 2.2 | O=C1NCC(Cc2ccccc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | ||
| 11706251 | 205304 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 517 | 3 | 3 | 4 | 2.0 | O=C1NC(=O)C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)N1 | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL577957 | 205304 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 517 | 3 | 3 | 4 | 2.0 | O=C1NC(=O)C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)N1 | 10.1016/j.bmcl.2009.09.066 | ||
| 76325057 | 111924 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 554 | 6 | 1 | 4 | 5.8 | CC(c1ccccc1)N1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114462 | 111924 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 554 | 6 | 1 | 4 | 5.8 | CC(c1ccccc1)N1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | ||
| 45487057 | 204587 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 516 | 3 | 2 | 4 | 2.4 | O=C1CC2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)C(=O)N1 | 10.1016/j.bmcl.2009.09.066 | ||
| CHEMBL572114 | 204587 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 516 | 3 | 2 | 4 | 2.4 | O=C1CC2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)C(=O)N1 | 10.1016/j.bmcl.2009.09.066 | ||
| 46885185 | 14741 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 502 | 2 | 1 | 7 | 2.8 | CN1C(=O)Cn2c(=O)n(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)Nc4ncccc43)c3cccc1c32 | 10.1016/j.bmcl.2010.02.086 | ||
| CHEMBL1090515 | 14741 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 502 | 2 | 1 | 7 | 2.8 | CN1C(=O)Cn2c(=O)n(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)Nc4ncccc43)c3cccc1c32 | 10.1016/j.bmcl.2010.02.086 | ||
| 11409395 | 99124 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 498 | 5 | 4 | 4 | 4.1 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ncc[nH]2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| CHEMBL2430183 | 99124 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 498 | 5 | 4 | 4 | 4.1 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ncc[nH]2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.08.031 | ||
| 11849020 | 101822 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 528 | 4 | 3 | 7 | 3.7 | O=C(Nc1cc(-c2ccc(O)cc2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| CHEMBL255136 | 101822 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6.0 | Functional | ChEMBL | 528 | 4 | 3 | 7 | 3.7 | O=C(Nc1cc(-c2ccc(O)cc2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | ||
| 44562983 | 198166 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 435 | 4 | 3 | 6 | 1.0 | COc1ccc2c(c1)[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | ||
| CHEMBL519242 | 198166 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 435 | 4 | 3 | 6 | 1.0 | COc1ccc2c(c1)[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | ||
| 59555258 | 111947 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2[C@H]2S[C@H](CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114485 | 111947 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7.0 | Functional | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2[C@H]2S[C@H](CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | ||
| 59555100 | 111943 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 611 | 7 | 1 | 5 | 6.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1-c1ccncc1 | 10.1016/j.bmcl.2013.12.089 | ||
| CHEMBL3114481 | 111943 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 611 | 7 | 1 | 5 | 6.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1-c1ccncc1 | 10.1016/j.bmcl.2013.12.089 | ||
| 70693851 | 80551 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 648 | 7 | 3 | 8 | 3.7 | O=C(C[C@H](Nc1nc(Cl)nc2[nH]ncc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | ||
| CHEMBL2018495 | 80551 | 0 | None | - | 1 | Human | 7.0 | pIC50 | = | 7 | Functional | ChEMBL | 648 | 7 | 3 | 8 | 3.7 | O=C(C[C@H](Nc1nc(Cl)nc2[nH]ncc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | ||
| 11713729 | 87325 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 551 | 4 | 2 | 7 | 3.6 | N#Cc1cn(C2CCN(C(=O)N[C@@H]3N=C(c4ccccc4)c4ccccc4N(CC(F)(F)F)C3=O)CC2)c(O)n1 | 10.1016/j.bmcl.2006.07.044 | ||
| CHEMBL214845 | 87325 | 0 | None | - | 1 | Human | 6.0 | pIC50 | = | 6 | Functional | ChEMBL | 551 | 4 | 2 | 7 | 3.6 | N#Cc1cn(C2CCN(C(=O)N[C@@H]3N=C(c4ccccc4)c4ccccc4N(CC(F)(F)F)C3=O)CC2)c(O)n1 | 10.1016/j.bmcl.2006.07.044 | ||
| 44403860 | 147841 | 0 | None | 75 | 2 | Human | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 853 | 12 | 5 | 10 | 4.3 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2c(O)nc3ccccc32)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | ||
| CHEMBL382469 | 147841 | 0 | None | 75 | 2 | Human | 10.1 | pKd | = | 10.1 | Functional | ChEMBL | 853 | 12 | 5 | 10 | 4.3 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2c(O)nc3ccccc32)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | ||
| 56944164 | 81863 | 3 | None | - | 1 | Human | 9.8 | pKd | = | 9.8 | Functional | ChEMBL | 572 | 4 | 3 | 6 | 3.3 | C[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | ||
| CHEMBL2035983 | 81863 | 3 | None | - | 1 | Human | 9.8 | pKd | = | 9.8 | Functional | ChEMBL | 572 | 4 | 3 | 6 | 3.3 | C[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | ||
| 44403859 | 140897 | 0 | None | - | 1 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 855 | 13 | 5 | 8 | 3.9 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N(C(N)=O)c2ccccc2)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | ||
| CHEMBL371646 | 140897 | 0 | None | - | 1 | Human | 9.1 | pKd | = | 9.1 | Functional | ChEMBL | 855 | 13 | 5 | 8 | 3.9 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N(C(N)=O)c2ccccc2)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | ||
| 44403858 | 79129 | 0 | None | - | 1 | Human | 8.0 | pKd | = | 8 | Functional | ChEMBL | 854 | 12 | 4 | 10 | 4.1 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2c(=O)oc3ccccc32)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | ||
| CHEMBL198502 | 79129 | 0 | None | - | 1 | Human | 8.0 | pKd | = | 8 | Functional | ChEMBL | 854 | 12 | 4 | 10 | 4.1 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2c(=O)oc3ccccc32)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | ||
| 44403855 | 79249 | 0 | None | 354 | 2 | Human | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 787 | 15 | 5 | 8 | 3.7 | COc1cccc(CCNC(=O)N[C@@H](Cc2cc(Br)c(O)c(Br)c2)C(=O)N[C@H](CCCCN)C(=O)N2CCN(c3ccncc3)CC2)c1 | 10.1021/jm0490641 | ||
| CHEMBL198925 | 79249 | 0 | None | 354 | 2 | Human | 6.9 | pKd | = | 6.9 | Functional | ChEMBL | 787 | 15 | 5 | 8 | 3.7 | COc1cccc(CCNC(=O)N[C@@H](Cc2cc(Br)c(O)c(Br)c2)C(=O)N[C@H](CCCCN)C(=O)N2CCN(c3ccncc3)CC2)c1 | 10.1021/jm0490641 | ||
| 57404496 | 80976 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 602 | 6 | 2 | 8 | 4.4 | Cc1cc(CC(OC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c2cc(C(=O)N(C)C)cc(Cl)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2023191 | 80976 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Functional | ChEMBL | 602 | 6 | 2 | 8 | 4.4 | Cc1cc(CC(OC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c2cc(C(=O)N(C)C)cc(Cl)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 25153832 | 207732 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 532 | 5 | 1 | 9 | 3.5 | Cc1ncc(-c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)n1C | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL601857 | 207732 | 0 | None | - | 0 | Human | 8.8 | pKi | = | 8.8 | Functional | ChEMBL | 532 | 5 | 1 | 9 | 3.5 | Cc1ncc(-c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)n1C | 10.1016/j.bmcl.2010.01.012 | ||
| 25153832 | 207732 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 532 | 5 | 1 | 9 | 3.5 | Cc1ncc(-c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)n1C | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL601857 | 207732 | 0 | None | - | 0 | Human | 7.0 | pKi | = | 7 | Functional | ChEMBL | 532 | 5 | 1 | 9 | 3.5 | Cc1ncc(-c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)n1C | 10.1016/j.bmcl.2010.01.012 | ||
| 46232565 | 207590 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 438 | 4 | 1 | 7 | 2.8 | O=C(Cc1nnc(-c2ccc(Cl)cc2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL600820 | 207590 | 0 | None | - | 0 | Human | 6.0 | pKi | = | 6 | Functional | ChEMBL | 438 | 4 | 1 | 7 | 2.8 | O=C(Cc1nnc(-c2ccc(Cl)cc2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25152370 | 207633 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 516 | 4 | 1 | 7 | 3.6 | O=C(Cc1nnc(-c2cc(Cl)cc(Br)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL601246 | 207633 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 516 | 4 | 1 | 7 | 3.6 | O=C(Cc1nnc(-c2cc(Cl)cc(Br)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 46232822 | 207817 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 552 | 8 | 1 | 7 | 4.0 | CN(C)CCOc1cc(Cl)cc(-c2nnc(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)o2)c1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL602475 | 207817 | 0 | None | - | 0 | Human | 7.9 | pKi | = | 7.9 | Functional | ChEMBL | 552 | 8 | 1 | 7 | 4.0 | CN(C)CCOc1cc(Cl)cc(-c2nnc(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)o2)c1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25152564 | 207494 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 472 | 4 | 1 | 7 | 3.5 | O=C(Cc1nnc(-c2cc(Cl)ccc2Cl)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL600010 | 207494 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 472 | 4 | 1 | 7 | 3.5 | O=C(Cc1nnc(-c2cc(Cl)ccc2Cl)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25152563 | 208236 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 440 | 4 | 1 | 7 | 2.5 | O=C(Cc1nnc(-c2cc(F)cc(F)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL604955 | 208236 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 440 | 4 | 1 | 7 | 2.5 | O=C(Cc1nnc(-c2cc(F)cc(F)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25110584 | 207600 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 523 | 5 | 1 | 9 | 2.7 | O=C(Cc1nnc(-c2cc(Cl)cc(N3CCOCC3)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL600837 | 207600 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 523 | 5 | 1 | 9 | 2.7 | O=C(Cc1nnc(-c2cc(Cl)cc(N3CCOCC3)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25154034 | 208997 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 529 | 5 | 1 | 8 | 4.2 | Cc1ccc(-c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)cn1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL609757 | 208997 | 0 | None | - | 0 | Human | 6.9 | pKi | = | 6.9 | Functional | ChEMBL | 529 | 5 | 1 | 8 | 4.2 | Cc1ccc(-c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)cn1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25152560 | 207767 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 472 | 4 | 1 | 7 | 3.5 | O=C(Cc1nnc(-c2cc(Cl)cc(Cl)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL602085 | 207767 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 472 | 4 | 1 | 7 | 3.5 | O=C(Cc1nnc(-c2cc(Cl)cc(Cl)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 46232822 | 207817 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 552 | 8 | 1 | 7 | 4.0 | CN(C)CCOc1cc(Cl)cc(-c2nnc(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)o2)c1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL602475 | 207817 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 552 | 8 | 1 | 7 | 4.0 | CN(C)CCOc1cc(Cl)cc(-c2nnc(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)o2)c1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25151968 | 209055 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 549 | 6 | 1 | 8 | 4.0 | CCN1CCC(c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL610062 | 209055 | 0 | None | - | 0 | Human | 7.8 | pKi | = | 7.8 | Functional | ChEMBL | 549 | 6 | 1 | 8 | 4.0 | CCN1CCC(c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 46232591 | 207902 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 472 | 4 | 1 | 7 | 3.5 | O=C(Cc1nnc(-c2cccc(Cl)c2Cl)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL603098 | 207902 | 0 | None | - | 0 | Human | 6.8 | pKi | = | 6.8 | Functional | ChEMBL | 472 | 4 | 1 | 7 | 3.5 | O=C(Cc1nnc(-c2cccc(Cl)c2Cl)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25151777 | 207729 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 535 | 5 | 1 | 8 | 3.6 | CN1CCC(c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL601854 | 207729 | 0 | None | - | 0 | Human | 7.7 | pKi | = | 7.7 | Functional | ChEMBL | 535 | 5 | 1 | 8 | 3.6 | CN1CCC(c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 46232693 | 206337 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 565 | 6 | 1 | 9 | 3.7 | O=C(Cc1nnc(-c2cc(-c3ccccc3)cc(N3CCOCC3)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL592406 | 206337 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 565 | 6 | 1 | 9 | 3.7 | O=C(Cc1nnc(-c2cc(-c3ccccc3)cc(N3CCOCC3)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 46232562 | 208161 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 404 | 4 | 1 | 7 | 2.2 | O=C(Cc1nnc(-c2ccccc2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL604539 | 208161 | 0 | None | - | 0 | Human | 6.7 | pKi | = | 6.7 | Functional | ChEMBL | 404 | 4 | 1 | 7 | 2.2 | O=C(Cc1nnc(-c2ccccc2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25152169 | 207599 | 0 | None | - | 0 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 514 | 5 | 1 | 7 | 4.5 | O=C(Cc1nnc(-c2cc(Cl)cc(-c3ccccc3)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL600836 | 207599 | 0 | None | - | 0 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 514 | 5 | 1 | 7 | 4.5 | O=C(Cc1nnc(-c2cc(Cl)cc(-c3ccccc3)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25154034 | 208997 | 0 | None | - | 0 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 529 | 5 | 1 | 8 | 4.2 | Cc1ccc(-c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)cn1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL609757 | 208997 | 0 | None | - | 0 | Human | 8.6 | pKi | = | 8.6 | Functional | ChEMBL | 529 | 5 | 1 | 8 | 4.2 | Cc1ccc(-c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)cn1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25152561 | 207618 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 456 | 4 | 1 | 7 | 3.0 | O=C(Cc1nnc(-c2cc(F)cc(Cl)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL601034 | 207618 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 456 | 4 | 1 | 7 | 3.0 | O=C(Cc1nnc(-c2cc(F)cc(Cl)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25152984 | 207669 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 540 | 4 | 1 | 7 | 4.2 | O=C(Cc1nnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL601455 | 207669 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 540 | 4 | 1 | 7 | 4.2 | O=C(Cc1nnc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25152985 | 207768 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 432 | 4 | 1 | 7 | 2.8 | Cc1cc(C)cc(-c2nnc(CC(=O)N3CCC(n4c(=O)[nH]c5ncccc54)CC3)o2)c1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL602086 | 207768 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 432 | 4 | 1 | 7 | 2.8 | Cc1cc(C)cc(-c2nnc(CC(=O)N3CCC(n4c(=O)[nH]c5ncccc54)CC3)o2)c1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25152167 | 207694 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 536 | 5 | 1 | 9 | 2.6 | CN1CCN(c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL601639 | 207694 | 0 | None | - | 0 | Human | 7.6 | pKi | = | 7.6 | Functional | ChEMBL | 536 | 5 | 1 | 9 | 2.6 | CN1CCN(c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 46232593 | 207819 | 0 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 472 | 4 | 1 | 7 | 3.5 | O=C(Cc1nnc(-c2ccc(Cl)c(Cl)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL602492 | 207819 | 0 | None | - | 0 | Human | 6.6 | pKi | = | 6.6 | Functional | ChEMBL | 472 | 4 | 1 | 7 | 3.5 | O=C(Cc1nnc(-c2ccc(Cl)c(Cl)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 46232527 | 207765 | 0 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 442 | 5 | 1 | 5 | 3.8 | COc1ccc(-c2ccccc2)cc1CC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL602075 | 207765 | 0 | None | - | 0 | Human | 5.6 | pKi | = | 5.6 | Functional | ChEMBL | 442 | 5 | 1 | 5 | 3.8 | COc1ccc(-c2ccccc2)cc1CC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25151968 | 209055 | 0 | None | - | 0 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 549 | 6 | 1 | 8 | 4.0 | CCN1CCC(c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL610062 | 209055 | 0 | None | - | 0 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 549 | 6 | 1 | 8 | 4.0 | CCN1CCC(c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 70685595 | 80973 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 612 | 6 | 2 | 6 | 5.8 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(C(=O)N(C)C)cc(Cl)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| CHEMBL2023188 | 80973 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Functional | ChEMBL | 612 | 6 | 2 | 6 | 5.8 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(C(=O)N(C)C)cc(Cl)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | ||
| 25154032 | 206375 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 585 | 7 | 1 | 8 | 4.3 | O=C(Cc1nnc(-c2cc(Cl)cc(C3CCN(CC(F)F)CC3)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL592649 | 206375 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 585 | 7 | 1 | 8 | 4.3 | O=C(Cc1nnc(-c2cc(Cl)cc(C3CCN(CC(F)F)CC3)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25152766 | 207571 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 506 | 4 | 1 | 7 | 3.9 | O=C(Cc1nnc(-c2cc(Cl)cc(C(F)(F)F)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL600636 | 207571 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 506 | 4 | 1 | 7 | 3.9 | O=C(Cc1nnc(-c2cc(Cl)cc(C(F)(F)F)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25151777 | 207729 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 535 | 5 | 1 | 8 | 3.6 | CN1CCC(c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL601854 | 207729 | 0 | None | - | 0 | Human | 8.4 | pKi | = | 8.4 | Functional | ChEMBL | 535 | 5 | 1 | 8 | 3.6 | CN1CCC(c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 46232564 | 207568 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 438 | 4 | 1 | 7 | 2.8 | O=C(Cc1nnc(-c2cccc(Cl)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL600620 | 207568 | 0 | None | - | 0 | Human | 6.5 | pKi | = | 6.5 | Functional | ChEMBL | 438 | 4 | 1 | 7 | 2.8 | O=C(Cc1nnc(-c2cccc(Cl)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25152167 | 207694 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 536 | 5 | 1 | 9 | 2.6 | CN1CCN(c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL601639 | 207694 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 536 | 5 | 1 | 9 | 2.6 | CN1CCN(c2cc(Cl)cc(-c3nnc(CC(=O)N4CCC(n5c(=O)[nH]c6ncccc65)CC4)o3)c2)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 46232777 | 208361 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 525 | 8 | 1 | 9 | 2.8 | CN(C)CCOc1cc(Cl)cc(-c2nnc(CC(=O)N3CCC(n4c(=O)[nH]c5ncccc54)CC3)o2)c1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL605579 | 208361 | 0 | None | - | 0 | Human | 8.3 | pKi | = | 8.3 | Functional | ChEMBL | 525 | 8 | 1 | 9 | 2.8 | CN(C)CCOc1cc(Cl)cc(-c2nnc(CC(=O)N3CCC(n4c(=O)[nH]c5ncccc54)CC3)o2)c1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25152981 | 207617 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 464 | 6 | 1 | 9 | 2.2 | COc1cc(OC)cc(-c2nnc(CC(=O)N3CCC(n4c(=O)[nH]c5ncccc54)CC3)o2)c1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL601033 | 207617 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 464 | 6 | 1 | 9 | 2.2 | COc1cc(OC)cc(-c2nnc(CC(=O)N3CCC(n4c(=O)[nH]c5ncccc54)CC3)o2)c1 | 10.1016/j.bmcl.2010.01.012 | ||
| 46232777 | 208361 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 525 | 8 | 1 | 9 | 2.8 | CN(C)CCOc1cc(Cl)cc(-c2nnc(CC(=O)N3CCC(n4c(=O)[nH]c5ncccc54)CC3)o2)c1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL605579 | 208361 | 0 | None | - | 0 | Human | 7.3 | pKi | = | 7.3 | Functional | ChEMBL | 525 | 8 | 1 | 9 | 2.8 | CN(C)CCOc1cc(Cl)cc(-c2nnc(CC(=O)N3CCC(n4c(=O)[nH]c5ncccc54)CC3)o2)c1 | 10.1016/j.bmcl.2010.01.012 | ||
| 46232563 | 207700 | 0 | None | - | 0 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 438 | 4 | 1 | 7 | 2.8 | O=C(Cc1nnc(-c2ccccc2Cl)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL601657 | 207700 | 0 | None | - | 0 | Human | 6.3 | pKi | = | 6.3 | Functional | ChEMBL | 438 | 4 | 1 | 7 | 2.8 | O=C(Cc1nnc(-c2ccccc2Cl)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25110584 | 207600 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 523 | 5 | 1 | 9 | 2.7 | O=C(Cc1nnc(-c2cc(Cl)cc(N3CCOCC3)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL600837 | 207600 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 523 | 5 | 1 | 9 | 2.7 | O=C(Cc1nnc(-c2cc(Cl)cc(N3CCOCC3)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25152765 | 208952 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 503 | 5 | 1 | 9 | 2.3 | Cc1cc(-c2nnc(CC(=O)N3CCC(n4c(=O)[nH]c5ncccc54)CC3)o2)cc(N2CCOCC2)c1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL609472 | 208952 | 0 | None | - | 0 | Human | 8.2 | pKi | = | 8.2 | Functional | ChEMBL | 503 | 5 | 1 | 9 | 2.3 | Cc1cc(-c2nnc(CC(=O)N3CCC(n4c(=O)[nH]c5ncccc54)CC3)o2)cc(N2CCOCC2)c1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25152367 | 208234 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 468 | 5 | 1 | 8 | 2.8 | COc1cc(Cl)cc(-c2nnc(CC(=O)N3CCC(n4c(=O)[nH]c5ncccc54)CC3)o2)c1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL604949 | 208234 | 0 | None | - | 0 | Human | 8.1 | pKi | = | 8.1 | Functional | ChEMBL | 468 | 5 | 1 | 8 | 2.8 | COc1cc(Cl)cc(-c2nnc(CC(=O)N3CCC(n4c(=O)[nH]c5ncccc54)CC3)o2)c1 | 10.1016/j.bmcl.2010.01.012 | ||
| 25154032 | 206375 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 585 | 7 | 1 | 8 | 4.3 | O=C(Cc1nnc(-c2cc(Cl)cc(C3CCN(CC(F)F)CC3)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL592649 | 206375 | 0 | None | - | 0 | Human | 7.1 | pKi | = | 7.1 | Functional | ChEMBL | 585 | 7 | 1 | 8 | 4.3 | O=C(Cc1nnc(-c2cc(Cl)cc(C3CCN(CC(F)F)CC3)c2)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| 46232592 | 207495 | 0 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 472 | 4 | 1 | 7 | 3.5 | O=C(Cc1nnc(-c2c(Cl)cccc2Cl)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| CHEMBL600011 | 207495 | 0 | None | - | 0 | Human | 6.1 | pKi | = | 6.1 | Functional | ChEMBL | 472 | 4 | 1 | 7 | 3.5 | O=C(Cc1nnc(-c2c(Cl)cccc2Cl)o1)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.01.012 | ||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 6918509 | 83817 | 41 | None | 131 | 2 | Human | 10.6 | pEC50 | = | 10.6 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2014.04.033 | |||
| CHEMBL207197 | 83817 | 41 | None | 131 | 2 | Human | 10.6 | pEC50 | = | 10.6 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2014.04.033 | |||
| 68857312 | 118725 | 0 | None | - | 0 | Human | 9.8 | pEC50 | = | 9.8 | Binding | ChEMBL | 881 | 12 | 5 | 10 | 3.2 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2c(=O)[nH]c3ccccc3c2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2014.04.033 | |||
| CHEMBL3288288 | 118725 | 0 | None | - | 0 | Human | 9.8 | pEC50 | = | 9.8 | Binding | ChEMBL | 881 | 12 | 5 | 10 | 3.2 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2c(=O)[nH]c3ccccc3c2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2014.04.033 | |||
| 86298538 | 118727 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 765 | 12 | 4 | 10 | 3.2 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2s1)NC(=O)N1CCC(n2c(=O)[nH]c3ccccc3c2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2014.04.033 | |||
| CHEMBL3288290 | 118727 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7 | Binding | ChEMBL | 765 | 12 | 4 | 10 | 3.2 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2s1)NC(=O)N1CCC(n2c(=O)[nH]c3ccccc3c2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2014.04.033 | |||
| 86298539 | 118726 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 751 | 12 | 4 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2s1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2014.04.033 | |||
| CHEMBL3288289 | 118726 | 0 | None | - | 0 | Human | 7.0 | pEC50 | = | 7.0 | Binding | ChEMBL | 751 | 12 | 4 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2s1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2014.04.033 | |||
| 6918509 | 83817 | 41 | None | 131 | 2 | Human | 10.7 | pIC50 | = | 10.7 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL207197 | 83817 | 41 | None | 131 | 2 | Human | 10.7 | pIC50 | = | 10.7 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2012.05.118 | |||
| 44403861 | 78798 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| CHEMBL197529 | 78798 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| 6918509 | 83817 | 41 | None | 131 | 2 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm500364u | |||
| CHEMBL207197 | 83817 | 41 | None | 131 | 2 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm500364u | |||
| CHEMBL3883526 | 219195 | 0 | None | - | 0 | Human | 10.5 | pIC50 | = | 10.5 | Binding | ChEMBL | None | None | None | CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)[C@@H](C)O)[C@@H](C)O)[C@H](C)O)[C@@H](C)O)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O)C(C)C | 10.1016/j.bmc.2016.11.014 | |||||
| CHEMBL2369459 | 216396 | 0 | None | - | 1 | Human | 10.4 | pIC50 | = | 10.4 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](C)N)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm8007618 | |||||
| 44403862 | 164674 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 879 | 13 | 5 | 10 | 4.8 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2cc(-c3ccccc3)nc2O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| CHEMBL408415 | 164674 | 0 | None | - | 0 | Human | 10.3 | pIC50 | = | 10.3 | Binding | ChEMBL | 879 | 13 | 5 | 10 | 4.8 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2cc(-c3ccccc3)nc2O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| 44403861 | 78798 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| CHEMBL197529 | 78798 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| 57404535 | 80573 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 625 | 7 | 2 | 5 | 4.9 | Cc1cc(C[C@@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018517 | 80573 | 0 | None | - | 0 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 625 | 7 | 2 | 5 | 4.9 | Cc1cc(C[C@@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| 57404496 | 80976 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 602 | 6 | 2 | 8 | 4.4 | Cc1cc(CC(OC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c2cc(C(=O)N(C)C)cc(Cl)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2023191 | 80976 | 0 | None | - | 1 | Human | 10.2 | pIC50 | = | 10.2 | Binding | ChEMBL | 602 | 6 | 2 | 8 | 4.4 | Cc1cc(CC(OC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c2cc(C(=O)N(C)C)cc(Cl)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 10416497 | 80560 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 625 | 7 | 2 | 5 | 4.9 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018504 | 80560 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 625 | 7 | 2 | 5 | 4.9 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| 57404529 | 80974 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 612 | 6 | 2 | 6 | 5.8 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(C(=O)N(C)C)cc(Cl)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2023189 | 80974 | 0 | None | - | 0 | Human | 10.1 | pIC50 | = | 10.1 | Binding | ChEMBL | 612 | 6 | 2 | 6 | 5.8 | Cc1cc(C[C@@H](OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(C(=O)N(C)C)cc(Cl)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 70683493 | 80975 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 629 | 6 | 2 | 6 | 5.6 | Cc1cc(CC(OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)c2cc(C(=O)N(C)C)cc(Cl)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2023190 | 80975 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 629 | 6 | 2 | 6 | 5.6 | Cc1cc(CC(OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)c2cc(C(=O)N(C)C)cc(Cl)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 70696079 | 80895 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 618 | 7 | 2 | 6 | 6.8 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(CN3CCCCCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2022606 | 80895 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10.0 | Binding | ChEMBL | 618 | 7 | 2 | 6 | 6.8 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(CN3CCCCCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 70696075 | 80890 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 607 | 7 | 2 | 6 | 6.2 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(CN3CCCCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2022601 | 80890 | 0 | None | - | 0 | Human | 10.0 | pIC50 | = | 10 | Binding | ChEMBL | 607 | 7 | 2 | 6 | 6.2 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(CN3CCCCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 70687597 | 80563 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 637 | 8 | 2 | 6 | 4.9 | Cc1cc(CC(CC(=O)N2CCC(n3cc(-c4ccccc4)[nH]c3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018507 | 80563 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 637 | 8 | 2 | 6 | 4.9 | Cc1cc(CC(CC(=O)N2CCC(n3cc(-c4ccccc4)[nH]c3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| 70681361 | 80892 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 604 | 7 | 2 | 6 | 6.4 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(CN3CCCCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2022603 | 80892 | 0 | None | - | 0 | Human | 9.8 | pIC50 | = | 9.8 | Binding | ChEMBL | 604 | 7 | 2 | 6 | 6.4 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(CN3CCCCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 11308219 | 80561 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 643 | 7 | 2 | 5 | 5.1 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018505 | 80561 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 643 | 7 | 2 | 5 | 5.1 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| 44403860 | 147841 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 853 | 12 | 5 | 10 | 4.3 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2c(O)nc3ccccc32)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| CHEMBL382469 | 147841 | 0 | None | - | 1 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 853 | 12 | 5 | 10 | 4.3 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2c(O)nc3ccccc32)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| 57404534 | 80575 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 643 | 7 | 2 | 5 | 5.1 | Cc1cc(C[C@@H](CC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018519 | 80575 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 643 | 7 | 2 | 5 | 5.1 | Cc1cc(C[C@@H](CC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| 11364682 | 81167 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 538 | 6 | 2 | 6 | 5.0 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(C=O)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024603 | 81167 | 0 | None | - | 0 | Human | 9.7 | pIC50 | = | 9.7 | Binding | ChEMBL | 538 | 6 | 2 | 6 | 5.0 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(C=O)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 70696077 | 80893 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 590 | 7 | 2 | 6 | 6.0 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(CN3CCCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2022604 | 80893 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 590 | 7 | 2 | 6 | 6.0 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(CN3CCCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 70681362 | 80898 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 586 | 6 | 2 | 5 | 6.9 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2c(-c3ccccc3)n[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2022609 | 80898 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 586 | 6 | 2 | 5 | 6.9 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2c(-c3ccccc3)n[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 70689756 | 80888 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 587 | 6 | 2 | 6 | 6.3 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(-c3ccncc3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2022599 | 80888 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 587 | 6 | 2 | 6 | 6.3 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(-c3ccncc3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 11308069 | 80889 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 621 | 6 | 2 | 6 | 5.8 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(C(=O)N3CCCCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2022600 | 80889 | 0 | None | - | 0 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 621 | 6 | 2 | 6 | 5.8 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(C(=O)N3CCCCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 70685595 | 80973 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 612 | 6 | 2 | 6 | 5.8 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(C(=O)N(C)C)cc(Cl)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2023188 | 80973 | 0 | None | - | 1 | Human | 9.6 | pIC50 | = | 9.6 | Binding | ChEMBL | 612 | 6 | 2 | 6 | 5.8 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(C(=O)N(C)C)cc(Cl)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 70681270 | 80564 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 622 | 7 | 2 | 5 | 5.1 | Cc1cc(CC(CC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018508 | 80564 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 622 | 7 | 2 | 5 | 5.1 | Cc1cc(CC(CC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| 24756690 | 80559 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 612 | 6 | 2 | 6 | 5.0 | Cc1cc(CC(CC(=O)N2CCC3(CC2)OC(=O)Nc2ccccc23)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018503 | 80559 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 612 | 6 | 2 | 6 | 5.0 | Cc1cc(CC(CC(=O)N2CCC3(CC2)OC(=O)Nc2ccccc23)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| 70691910 | 80887 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 581 | 6 | 2 | 6 | 4.9 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(C(=O)N(C)C)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2022598 | 80887 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 581 | 6 | 2 | 6 | 4.9 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(C(=O)N(C)C)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 70685565 | 80896 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 588 | 5 | 2 | 5 | 6.0 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2c(Br)n[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2022607 | 80896 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 588 | 5 | 2 | 5 | 6.0 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2c(Br)n[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 11169454 | 80562 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 611 | 6 | 3 | 5 | 4.6 | Cc1cc(CC(CC(=O)N2CCC3(CC2)NC(=O)Nc2ccccc23)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018506 | 80562 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 611 | 6 | 3 | 5 | 4.6 | Cc1cc(CC(CC(=O)N2CCC3(CC2)NC(=O)Nc2ccccc23)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| 11786642 | 81159 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 588 | 5 | 2 | 5 | 6.0 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cccc(Br)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024595 | 81159 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 588 | 5 | 2 | 5 | 6.0 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cccc(Br)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 70685566 | 80897 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 544 | 5 | 2 | 5 | 5.9 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2c(Cl)n[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2022608 | 80897 | 0 | None | - | 0 | Human | 9.4 | pIC50 | = | 9.4 | Binding | ChEMBL | 544 | 5 | 2 | 5 | 5.9 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2c(Cl)n[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 11295951 | 81163 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 560 | 5 | 2 | 5 | 6.4 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc3ccccc3cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024599 | 81163 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 560 | 5 | 2 | 5 | 6.4 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc3ccccc3cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 11215446 | 81158 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 587 | 5 | 3 | 4 | 5.5 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cccc(Br)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024594 | 81158 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | 587 | 5 | 3 | 4 | 5.5 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cccc(Br)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2369463 | 216398 | 0 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| CHEMBL525571 | 222431 | 25 | None | - | 0 | Human | 9.3 | pIC50 | = | 9.3 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| CHEMBL525571 | 222431 | 25 | None | - | 0 | Rat | 9.2 | pIC50 | = | 9.2 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| 11467108 | 81162 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 559 | 5 | 3 | 4 | 5.9 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc3ccccc3cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024598 | 81162 | 0 | None | - | 0 | Human | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | 559 | 5 | 3 | 4 | 5.9 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc3ccccc3cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2369463 | 216398 | 0 | None | - | 0 | Rat | 9.1 | pIC50 | = | 9.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| 11341642 | 81153 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 536 | 7 | 2 | 5 | 4.8 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc(C=O)cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024589 | 81153 | 0 | None | - | 0 | Human | 9.0 | pIC50 | = | 9.0 | Binding | ChEMBL | 536 | 7 | 2 | 5 | 4.8 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc(C=O)cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 70696078 | 80894 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 606 | 7 | 2 | 7 | 5.2 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(CN3CCOCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2022605 | 80894 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 606 | 7 | 2 | 7 | 5.2 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2cc(CN3CCOCC3)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 70696080 | 80899 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 538 | 6 | 2 | 6 | 5.0 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2c(C=O)n[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2022610 | 80899 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 538 | 6 | 2 | 6 | 5.0 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2c(C=O)n[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 11398863 | 81161 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 560 | 5 | 2 | 5 | 6.4 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc3ccccc3n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024597 | 81161 | 0 | None | - | 0 | Human | 8.9 | pIC50 | = | 8.9 | Binding | ChEMBL | 560 | 5 | 2 | 5 | 6.4 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc3ccccc3n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 11466363 | 81157 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 510 | 5 | 2 | 5 | 5.2 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024593 | 81157 | 0 | None | - | 0 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | 510 | 5 | 2 | 5 | 5.2 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2369459 | 216396 | 0 | None | - | 1 | Human | 8.8 | pIC50 | = | 8.8 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](C)N)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| 11192748 | 81154 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 605 | 8 | 2 | 5 | 6.0 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc(CN3CCCCC3)cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024590 | 81154 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 605 | 8 | 2 | 5 | 6.0 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc(CN3CCCCC3)cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 70693987 | 80971 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 609 | 7 | 2 | 7 | 5.0 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2c(CN3CCOCC3)n[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2023186 | 80971 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 609 | 7 | 2 | 7 | 5.0 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2c(CN3CCOCC3)n[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2369452 | 216392 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| 11191890 | 81075 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 536 | 7 | 2 | 4 | 5.6 | CCc1ccnc(C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)Cc2cc(C)c3[nH]ncc3c2)c1 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024172 | 81075 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8 | Binding | ChEMBL | 536 | 7 | 2 | 4 | 5.6 | CCc1ccnc(C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)Cc2cc(C)c3[nH]ncc3c2)c1 | 10.1016/j.bmcl.2012.02.065 | |||
| 44403854 | 78992 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 787 | 15 | 5 | 8 | 3.7 | COc1ccccc1CCNC(=O)N[C@@H](Cc1cc(Br)c(O)c(Br)c1)C(=O)N[C@H](CCCCN)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| CHEMBL198105 | 78992 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 787 | 15 | 5 | 8 | 3.7 | COc1ccccc1CCNC(=O)N[C@@H](Cc1cc(Br)c(O)c(Br)c1)C(=O)N[C@H](CCCCN)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| CHEMBL216229 | 216100 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL267137 | 217490 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL267182 | 217491 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL269027 | 217553 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL405694 | 219354 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL409205 | 219531 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL438008 | 220521 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL438224 | 220536 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 44403917 | 79069 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 755 | 15 | 4 | 7 | 4.2 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(N)c(Br)c1)NC(=O)CCCc1ccccc1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| CHEMBL198311 | 79069 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5.0 | Binding | ChEMBL | 755 | 15 | 4 | 7 | 4.2 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(N)c(Br)c1)NC(=O)CCCc1ccccc1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| CHEMBL2369454 | 216393 | 0 | None | - | 0 | Rat | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| 70689654 | 80574 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 625 | 7 | 2 | 5 | 4.9 | Cc1cc(C[C@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018518 | 80574 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | 625 | 7 | 2 | 5 | 4.9 | Cc1cc(C[C@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2369457 | 216394 | 0 | None | - | 0 | Human | 8.0 | pIC50 | = | 8.0 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| CHEMBL2369454 | 216393 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| 70696076 | 80891 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 507 | 5 | 2 | 5 | 5.4 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2022602 | 80891 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 507 | 5 | 2 | 5 | 5.4 | Cc1cc(CC(OC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 11785754 | 81151 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 522 | 6 | 2 | 4 | 5.3 | Cc1ccc(C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)Cc2cc(C)c3[nH]ncc3c2)nc1 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024587 | 81151 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 522 | 6 | 2 | 4 | 5.3 | Cc1ccc(C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)Cc2cc(C)c3[nH]ncc3c2)nc1 | 10.1016/j.bmcl.2012.02.065 | |||
| 11215412 | 81164 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 585 | 6 | 3 | 4 | 6.4 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cccc(-c3ccccc3)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024600 | 81164 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | 585 | 6 | 3 | 4 | 6.4 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cccc(-c3ccccc3)n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 70685454 | 80557 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 700 | 7 | 2 | 5 | 6.3 | O=C(C[C@H](Nc1ccc(Br)c2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018501 | 80557 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 700 | 7 | 2 | 5 | 6.3 | O=C(C[C@H](Nc1ccc(Br)c2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL216710 | 216118 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 44323097 | 213292 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 494 | 7 | 1 | 5 | 6.9 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2ccc(Oc3ccccc3)cc2)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| CHEMBL88441 | 213292 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 494 | 7 | 1 | 5 | 6.9 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2ccc(Oc3ccccc3)cc2)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| 58864453 | 80470 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 626 | 8 | 3 | 6 | 3.9 | O=C(C[C@H](NCc1ccc2[nH]ncc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018356 | 80470 | 0 | None | - | 0 | Human | 6.9 | pIC50 | = | 6.9 | Binding | ChEMBL | 626 | 8 | 3 | 6 | 3.9 | O=C(C[C@H](NCc1ccc2[nH]ncc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| 44403853 | 79195 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 745 | 17 | 6 | 6 | 4.4 | COc1ccccc1CCNC(=O)N[C@@H](Cc1cc(Br)c(O)c(Br)c1)C(=O)N[C@H](CCCCN)C(=O)NCCc1ccccc1 | 10.1021/jm0490641 | |||
| CHEMBL198762 | 79195 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | 745 | 17 | 6 | 6 | 4.4 | COc1ccccc1CCNC(=O)N[C@@H](Cc1cc(Br)c(O)c(Br)c1)C(=O)N[C@H](CCCCN)C(=O)NCCc1ccccc1 | 10.1021/jm0490641 | |||
| CHEMBL2369742 | 216445 | 0 | None | - | 0 | Human | 7.9 | pIC50 | = | 7.9 | Binding | ChEMBL | None | None | None | CC(C)[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C | 10.1016/0960-894X(95)00078-8 | |||||
| CHEMBL2369457 | 216394 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| 70696851 | 83285 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 627 | 6 | 2 | 7 | 3.8 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC2(CC1)N=C(c1ccncc1)NC2=O | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL2059903 | 83285 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 627 | 6 | 2 | 7 | 3.8 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC2(CC1)N=C(c1ccncc1)NC2=O | 10.1016/j.bmcl.2012.05.118 | |||
| 58864279 | 80549 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 574 | 7 | 2 | 7 | 3.2 | O=C(C[C@H](Nc1ccncn1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018493 | 80549 | 0 | None | - | 0 | Human | 5.9 | pIC50 | = | 5.9 | Binding | ChEMBL | 574 | 7 | 2 | 7 | 3.2 | O=C(C[C@H](Nc1ccncn1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL376040 | 219020 | 0 | None | - | 0 | Human | 4.9 | pIC50 | = | 4.9 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL2371143 | 216794 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1)C(N)=O | 10.1021/jm970533r | |||||
| 24756769 | 80570 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 598 | 6 | 2 | 6 | 4.7 | O=C1Nc2ccccc2C2(CCN(C(=O)CC(Cc3ccc4[nH]ncc4c3)C(=O)N3CCC(N4CCCCC4)CC3)CC2)O1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018514 | 80570 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | 598 | 6 | 2 | 6 | 4.7 | O=C1Nc2ccccc2C2(CCN(C(=O)CC(Cc3ccc4[nH]ncc4c3)C(=O)N3CCC(N4CCCCC4)CC3)CC2)O1 | 10.1016/j.bmcl.2012.02.066 | |||
| 24756612 | 83280 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 613 | 5 | 2 | 5 | 4.8 | O=C1NCC2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL2059898 | 83280 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 613 | 5 | 2 | 5 | 4.8 | O=C1NCC2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL406459 | 219388 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL2369464 | 216399 | 0 | None | - | 0 | Human | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| CHEMBL2369464 | 216399 | 0 | None | - | 0 | Rat | 7.8 | pIC50 | = | 7.8 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| CHEMBL411804 | 219737 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | None | None | None | CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)[C@@H](C)O)C(=O)NCC(=O)NC(C)(C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm970533r | |||||
| 70690619 | 83277 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 599 | 5 | 2 | 5 | 5.0 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC2(CC1)C(=O)Nc1ccccc12 | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL2059895 | 83277 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 599 | 5 | 2 | 5 | 5.0 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC2(CC1)C(=O)Nc1ccccc12 | 10.1016/j.bmcl.2012.05.118 | |||
| 58901616 | 80555 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 612 | 7 | 3 | 6 | 4.2 | O=C(C[C@H](Nc1ccc2[nH]ncc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018499 | 80555 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 612 | 7 | 3 | 6 | 4.2 | O=C(C[C@H](Nc1ccc2[nH]ncc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| 11534977 | 79038 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 714 | 17 | 5 | 5 | 4.9 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)CCCc1ccccc1)C(=O)NCCc1ccccc1 | 10.1021/jm0490641 | |||
| CHEMBL198232 | 79038 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 714 | 17 | 5 | 5 | 4.9 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)CCCc1ccccc1)C(=O)NCCc1ccccc1 | 10.1021/jm0490641 | |||
| 11578671 | 78500 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 714 | 17 | 5 | 5 | 4.9 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)CCCc1ccccc1)C(=O)NCCc1ccccc1 | 10.1021/jm500364u | |||
| CHEMBL196582 | 78500 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 714 | 17 | 5 | 5 | 4.9 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)CCCc1ccccc1)C(=O)NCCc1ccccc1 | 10.1021/jm500364u | |||
| 44323001 | 112958 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 454 | 5 | 1 | 4 | 5.9 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2ccc(F)c(Cl)c2)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| CHEMBL313797 | 112958 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | 454 | 5 | 1 | 4 | 5.9 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2ccc(F)c(Cl)c2)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| 58864479 | 80554 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 611 | 7 | 3 | 5 | 4.9 | O=C(C[C@H](Nc1ccc2[nH]ccc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018498 | 80554 | 0 | None | - | 0 | Human | 6.8 | pIC50 | = | 6.8 | Binding | ChEMBL | 611 | 7 | 3 | 5 | 4.9 | O=C(C[C@H](Nc1ccc2[nH]ccc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL267406 | 217498 | 0 | None | - | 0 | Human | 4.8 | pIC50 | = | 4.8 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 56675112 | 70111 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 3187 | 105 | 47 | 49 | -19.7 | CC(C)C[C@H](NC(=O)COCCOCCNC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1016/0960-894X(95)00078-8 | |||
| 91930235 | 70111 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 3187 | 105 | 47 | 49 | -19.7 | CC(C)C[C@H](NC(=O)COCCOCCNC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1016/0960-894X(95)00078-8 | |||
| CHEMBL1794015 | 70111 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 3187 | 105 | 47 | 49 | -19.7 | CC(C)C[C@H](NC(=O)COCCOCCNC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1016/0960-894X(95)00078-8 | |||
| 24756768 | 80568 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 529 | 5 | 2 | 5 | 4.5 | Cc1cc(CC(CC(=O)N2CCC3(CC2)OC(=O)Nc2ccccc23)C(=O)N2CCCCC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018512 | 80568 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 529 | 5 | 2 | 5 | 4.5 | Cc1cc(CC(CC(=O)N2CCC3(CC2)OC(=O)Nc2ccccc23)C(=O)N2CCCCC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL3350392 | 218257 | 0 | None | - | 0 | Human | 4.7 | pIC50 | = | 4.7 | Binding | ChEMBL | None | None | None | CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm970533r | |||||
| CHEMBL2369459 | 216396 | 0 | None | - | 1 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](C)N)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| 11226747 | 81160 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 559 | 5 | 3 | 4 | 5.9 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc3ccccc3n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024596 | 81160 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 559 | 5 | 3 | 4 | 5.9 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc3ccccc3n2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 11387141 | 81166 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 540 | 6 | 3 | 6 | 4.7 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(CO)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024602 | 81166 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | 540 | 6 | 3 | 6 | 4.7 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(CO)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL3037882 | 217704 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1016/0960-894X(95)00078-8 | |||||
| CHEMBL3037882 | 217704 | 0 | None | - | 0 | Human | 8.7 | pIC50 | = | 8.7 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1016/0960-894X(95)00078-8 | |||||
| CHEMBL2369463 | 216398 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| CHEMBL525571 | 222431 | 25 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| CHEMBL2369459 | 216396 | 0 | None | - | 1 | Rat | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](C)N)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| 44403860 | 147841 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 853 | 12 | 5 | 10 | 4.3 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2c(O)nc3ccccc32)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| CHEMBL382469 | 147841 | 0 | None | - | 1 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 853 | 12 | 5 | 10 | 4.3 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2c(O)nc3ccccc32)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| 86298538 | 118727 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 765 | 12 | 4 | 10 | 3.2 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2s1)NC(=O)N1CCC(n2c(=O)[nH]c3ccccc3c2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2014.04.033 | |||
| CHEMBL3288290 | 118727 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 765 | 12 | 4 | 10 | 3.2 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2s1)NC(=O)N1CCC(n2c(=O)[nH]c3ccccc3c2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2014.04.033 | |||
| 21102037 | 80567 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 556 | 6 | 2 | 4 | 4.7 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(C)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018511 | 80567 | 0 | None | - | 0 | Human | 8.6 | pIC50 | = | 8.6 | Binding | ChEMBL | 556 | 6 | 2 | 4 | 4.7 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(C)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| 70694804 | 83282 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 626 | 6 | 2 | 6 | 4.4 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC2(CC1)N=C(c1ccccc1)NC2=O | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL2059900 | 83282 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 626 | 6 | 2 | 6 | 4.4 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC2(CC1)N=C(c1ccccc1)NC2=O | 10.1016/j.bmcl.2012.05.118 | |||
| 21102224 | 83287 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 615 | 5 | 2 | 6 | 5.6 | O=C1Nc2ccccc2C2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)O1 | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL2059905 | 83287 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | 615 | 5 | 2 | 6 | 5.6 | O=C1Nc2ccccc2C2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)O1 | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL2369464 | 216399 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| 44403855 | 79249 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 787 | 15 | 5 | 8 | 3.7 | COc1cccc(CCNC(=O)N[C@@H](Cc2cc(Br)c(O)c(Br)c2)C(=O)N[C@H](CCCCN)C(=O)N2CCN(c3ccncc3)CC2)c1 | 10.1021/jm0490641 | |||
| CHEMBL198925 | 79249 | 0 | None | - | 1 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 787 | 15 | 5 | 8 | 3.7 | COc1cccc(CCNC(=O)N[C@@H](Cc2cc(Br)c(O)c(Br)c2)C(=O)N[C@H](CCCCN)C(=O)N2CCN(c3ccncc3)CC2)c1 | 10.1021/jm0490641 | |||
| CHEMBL429765 | 220325 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL268539 | 217536 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)[C@@H](C)O)C(C)C | 10.1021/jm970533r | |||||
| CHEMBL2369465 | 216400 | 0 | None | - | 0 | Human | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| 70684299 | 83286 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 627 | 6 | 2 | 7 | 3.8 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC2(CC1)N=C(c1cccnc1)NC2=O | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL2059904 | 83286 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 627 | 6 | 2 | 7 | 3.8 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC2(CC1)N=C(c1cccnc1)NC2=O | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL2369457 | 216394 | 0 | None | - | 0 | Rat | 7.7 | pIC50 | = | 7.7 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| CHEMBL20034 | 215886 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 70681269 | 80558 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 622 | 7 | 2 | 5 | 5.5 | O=C(C[C@H](Nc1cccc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018502 | 80558 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 622 | 7 | 2 | 5 | 5.5 | O=C(C[C@H](Nc1cccc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| 44403856 | 77257 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 828 | 13 | 4 | 9 | 3.7 | COc1ccccc1N1CCN(C(=O)N[C@@H](Cc2cc(Br)c(O)c(Br)c2)C(=O)N[C@H](CCCCN)C(=O)N2CCN(c3ccncc3)CC2)CC1 | 10.1021/jm0490641 | |||
| CHEMBL194631 | 77257 | 0 | None | - | 0 | Human | 6.7 | pIC50 | = | 6.7 | Binding | ChEMBL | 828 | 13 | 4 | 9 | 3.7 | COc1ccccc1N1CCN(C(=O)N[C@@H](Cc2cc(Br)c(O)c(Br)c2)C(=O)N[C@H](CCCCN)C(=O)N2CCN(c3ccncc3)CC2)CC1 | 10.1021/jm0490641 | |||
| 24756611 | 83278 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 613 | 5 | 2 | 5 | 5.4 | O=C1CC2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)c2ccccc2N1 | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL2059896 | 83278 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 613 | 5 | 2 | 5 | 5.4 | O=C1CC2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)c2ccccc2N1 | 10.1016/j.bmcl.2012.05.118 | |||
| 11249157 | 81155 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 505 | 6 | 2 | 4 | 5.2 | Cc1cc(CC(CC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024591 | 81155 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 505 | 6 | 2 | 4 | 5.2 | Cc1cc(CC(CC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL404977 | 219316 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL439085 | 220599 | 0 | None | - | 0 | Human | 4.6 | pIC50 | = | 4.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL2369465 | 216400 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| 86298539 | 118726 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 751 | 12 | 4 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2s1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2014.04.033 | |||
| CHEMBL3288289 | 118726 | 0 | None | - | 0 | Human | 7.6 | pIC50 | = | 7.6 | Binding | ChEMBL | 751 | 12 | 4 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc2ccccc2s1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2014.04.033 | |||
| 44403857 | 77258 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 827 | 13 | 4 | 8 | 4.8 | COc1ccccc1C1CCN(C(=O)N[C@@H](Cc2cc(Br)c(O)c(Br)c2)C(=O)N[C@H](CCCCN)C(=O)N2CCN(c3ccncc3)CC2)CC1 | 10.1021/jm0490641 | |||
| CHEMBL194632 | 77258 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 827 | 13 | 4 | 8 | 4.8 | COc1ccccc1C1CCN(C(=O)N[C@@H](Cc2cc(Br)c(O)c(Br)c2)C(=O)N[C@H](CCCCN)C(=O)N2CCN(c3ccncc3)CC2)CC1 | 10.1021/jm0490641 | |||
| 70693851 | 80551 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 648 | 7 | 3 | 8 | 3.7 | O=C(C[C@H](Nc1nc(Cl)nc2[nH]ncc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018495 | 80551 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 648 | 7 | 3 | 8 | 3.7 | O=C(C[C@H](Nc1nc(Cl)nc2[nH]ncc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL407774 | 219462 | 0 | None | - | 0 | Human | 5.6 | pIC50 | = | 5.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL407854 | 219467 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 58864407 | 80543 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 616 | 7 | 2 | 6 | 4.0 | O=C(N[C@@H](CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCC(N2CCCCC2)CC1)Oc1ccccc1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018487 | 80543 | 0 | None | - | 0 | Human | 6.6 | pIC50 | = | 6.6 | Binding | ChEMBL | 616 | 7 | 2 | 6 | 4.0 | O=C(N[C@@H](CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCC(N2CCCCC2)CC1)Oc1ccccc1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL264010 | 217381 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 70694803 | 83279 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 613 | 5 | 2 | 5 | 4.7 | O=C1Cc2ccccc2C2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)N1 | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL2059897 | 83279 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 613 | 5 | 2 | 5 | 4.7 | O=C1Cc2ccccc2C2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)N1 | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL2369454 | 216393 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| 25034109 | 185273 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 628 | 6 | 2 | 5 | 5.5 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL466555 | 185273 | 0 | None | - | 1 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 628 | 6 | 2 | 5 | 5.5 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.05.118 | |||
| 70683458 | 80886 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 535 | 5 | 2 | 6 | 5.1 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(C#N)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2022597 | 80886 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 535 | 5 | 2 | 6 | 5.1 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(C#N)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 11295168 | 81156 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 509 | 5 | 3 | 4 | 4.8 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024592 | 81156 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 509 | 5 | 3 | 4 | 4.8 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 10438558 | 80565 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 600 | 6 | 2 | 6 | 3.8 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC3(CC2)OCCO3)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018509 | 80565 | 0 | None | - | 0 | Human | 8.5 | pIC50 | = | 8.5 | Binding | ChEMBL | 600 | 6 | 2 | 6 | 3.8 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC3(CC2)OCCO3)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| 21102038 | 80569 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 542 | 6 | 2 | 4 | 4.5 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCCCC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018513 | 80569 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 542 | 6 | 2 | 4 | 4.5 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCCCC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| 11341430 | 81165 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 523 | 5 | 3 | 4 | 5.1 | Cc1cccc(C(Cc2cc(C)c3[nH]ncc3c2)NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)n1 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024601 | 81165 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 523 | 5 | 3 | 4 | 5.1 | Cc1cccc(C(Cc2cc(C)c3[nH]ncc3c2)NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)n1 | 10.1016/j.bmcl.2012.02.065 | |||
| 11238250 | 80884 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 554 | 6 | 3 | 6 | 4.9 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(C(=O)O)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2022595 | 80884 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 554 | 6 | 3 | 6 | 4.9 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2cc(C(=O)O)ccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL384581 | 219110 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | None | None | None | CC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)[C@@H](C)O)C(C)C | 10.1021/jm970533r | |||||
| CHEMBL407740 | 219460 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL440990 | 220653 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 70685453 | 80550 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 651 | 8 | 2 | 7 | 4.9 | O=C(C[C@H](Nc1ccc(Cl)cc1[N+](=O)[O-])C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018494 | 80550 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 651 | 8 | 2 | 7 | 4.9 | O=C(C[C@H](Nc1ccc(Cl)cc1[N+](=O)[O-])C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL405767 | 219357 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL2369465 | 216400 | 0 | None | - | 0 | Rat | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| 70686453 | 83283 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 628 | 6 | 2 | 6 | 4.4 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL2059901 | 83283 | 0 | None | - | 0 | Human | 6.5 | pIC50 | = | 6.5 | Binding | ChEMBL | 628 | 6 | 2 | 6 | 4.4 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC2(CC1)C(=O)NCN2c1ccccc1 | 10.1016/j.bmcl.2012.05.118 | |||
| 44323139 | 213093 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 452 | 5 | 1 | 4 | 6.2 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2cccc3ccccc23)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| CHEMBL87174 | 213093 | 0 | None | - | 0 | Human | 4.5 | pIC50 | = | 4.5 | Binding | ChEMBL | 452 | 5 | 1 | 4 | 6.2 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2cccc3ccccc23)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| CHEMBL407401 | 219439 | 0 | None | - | 0 | Human | 5.5 | pIC50 | = | 5.5 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 11443894 | 81074 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 526 | 6 | 2 | 4 | 5.2 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024171 | 81074 | 0 | None | - | 0 | Human | 7.5 | pIC50 | = | 7.5 | Binding | ChEMBL | 526 | 6 | 2 | 4 | 5.2 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 58864296 | 80545 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 683 | 7 | 3 | 5 | 5.4 | O=C(Nc1ccc(Cl)cc1Cl)N[C@@H](CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCC(N2CCCCC2)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018489 | 80545 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 683 | 7 | 3 | 5 | 5.4 | O=C(Nc1ccc(Cl)cc1Cl)N[C@@H](CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCC(N2CCCCC2)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL405511 | 219342 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 44323338 | 213316 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 470 | 5 | 1 | 4 | 6.4 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2ccc(Cl)cc2Cl)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| CHEMBL88582 | 213316 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 470 | 5 | 1 | 4 | 6.4 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2ccc(Cl)cc2Cl)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| 70681261 | 80469 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 625 | 8 | 3 | 5 | 4.5 | O=C(C[C@H](NCc1ccc2[nH]ccc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018355 | 80469 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 625 | 8 | 3 | 5 | 4.5 | O=C(C[C@H](NCc1ccc2[nH]ccc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| 70688557 | 83276 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 614 | 6 | 3 | 6 | 4.7 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(C2CCNCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL2059881 | 83276 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 614 | 6 | 3 | 6 | 4.7 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(C2CCNCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL2369742 | 216445 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | None | None | None | CC(C)[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(C)C)C(C)C)C(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C | 10.1016/0960-894X(95)00078-8 | |||||
| 70687709 | 80885 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 568 | 6 | 2 | 7 | 5.0 | COC(=O)c1ccnc(C(Cc2cc(C)c3[nH]ncc3c2)OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c1 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2022596 | 80885 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 568 | 6 | 2 | 7 | 5.0 | COC(=O)c1ccnc(C(Cc2cc(C)c3[nH]ncc3c2)OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c1 | 10.1016/j.bmcl.2012.02.065 | |||
| 11156698 | 81076 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 522 | 6 | 2 | 4 | 5.3 | Cc1cccnc1C(CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)Cc1cc(C)c2[nH]ncc2c1 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024173 | 81076 | 0 | None | - | 0 | Human | 8.4 | pIC50 | = | 8.4 | Binding | ChEMBL | 522 | 6 | 2 | 4 | 5.3 | Cc1cccnc1C(CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)Cc1cc(C)c2[nH]ncc2c1 | 10.1016/j.bmcl.2012.02.065 | |||
| 44403859 | 140897 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 855 | 13 | 5 | 8 | 3.9 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N(C(N)=O)c2ccccc2)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| CHEMBL371646 | 140897 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 855 | 13 | 5 | 8 | 3.9 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N(C(N)=O)c2ccccc2)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| CHEMBL404978 | 219317 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 44404069 | 179553 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 713 | 17 | 5 | 5 | 4.8 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(N)c(Br)c1)NC(=O)CCCc1ccccc1)C(=O)NCCc1ccccc1 | 10.1021/jm0490641 | |||
| CHEMBL451246 | 179553 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 713 | 17 | 5 | 5 | 4.8 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(N)c(Br)c1)NC(=O)CCCc1ccccc1)C(=O)NCCc1ccccc1 | 10.1021/jm0490641 | |||
| 44323332 | 119167 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 447 | 6 | 1 | 6 | 5.0 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2cccc([N+](=O)[O-])c2)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| CHEMBL329678 | 119167 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | 447 | 6 | 1 | 6 | 5.0 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2cccc([N+](=O)[O-])c2)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| CHEMBL269328 | 217564 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 58864477 | 80472 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 636 | 7 | 2 | 5 | 4.0 | O=C(N[C@@H](CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCC(N2CCCCC2)CC1)c1ccc(F)c(F)c1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018358 | 80472 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 636 | 7 | 2 | 5 | 4.0 | O=C(N[C@@H](CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCC(N2CCCCC2)CC1)c1ccc(F)c(F)c1 | 10.1016/j.bmcl.2012.02.066 | |||
| 44403858 | 79129 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 854 | 12 | 4 | 10 | 4.1 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2c(=O)oc3ccccc32)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| CHEMBL198502 | 79129 | 0 | None | - | 1 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 854 | 12 | 4 | 10 | 4.1 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2c(=O)oc3ccccc32)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| 11693761 | 121243 | 1 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 854 | 12 | 4 | 10 | 4.1 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2c(=O)oc3ccccc32)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm500364u | |||
| CHEMBL3334623 | 121243 | 1 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 854 | 12 | 4 | 10 | 4.1 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2c(=O)oc3ccccc32)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm500364u | |||
| 58864506 | 80546 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 633 | 7 | 3 | 5 | 4.2 | O=C(Nc1ccccc1F)N[C@@H](CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCC(N2CCCCC2)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018490 | 80546 | 0 | None | - | 0 | Human | 7.4 | pIC50 | = | 7.4 | Binding | ChEMBL | 633 | 7 | 3 | 5 | 4.2 | O=C(Nc1ccccc1F)N[C@@H](CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCC(N2CCCCC2)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL262749 | 217326 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | None | None | None | CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)[C@@H](C)O)C(C)C | 10.1021/jm970533r | |||||
| CHEMBL406587 | 219393 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 58864520 | 80471 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 594 | 7 | 3 | 6 | 3.2 | O=C(C[C@H](NC1CCC(O)CC1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018357 | 80471 | 0 | None | - | 0 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 594 | 7 | 3 | 6 | 3.2 | O=C(C[C@H](NC1CCC(O)CC1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL262961 | 217333 | 0 | None | - | 0 | Human | 4.4 | pIC50 | = | 4.4 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 24756770 | 80572 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 573 | 5 | 2 | 7 | 3.6 | O=C1Nc2ccccc2C2(CCN(C(=O)CC(Cc3ccc4[nH]ncc4c3)C(=O)N3CCC4(CC3)OCCO4)CC2)O1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018516 | 80572 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | 573 | 5 | 2 | 7 | 3.6 | O=C1Nc2ccccc2C2(CCN(C(=O)CC(Cc3ccc4[nH]ncc4c3)C(=O)N3CCC4(CC3)OCCO4)CC2)O1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL274851 | 217596 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL411078 | 219640 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL217867 | 216162 | 0 | None | - | 0 | Human | 6.3 | pIC50 | = | 6.3 | Binding | ChEMBL | None | None | None | CC(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)[C@@H](C)O | 10.1021/jm970533r | |||||
| 62705051 | 83288 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 614 | 5 | 3 | 5 | 5.1 | O=C1Nc2ccccc2C2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)N1 | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL2059906 | 83288 | 0 | None | - | 0 | Human | 8.3 | pIC50 | = | 8.3 | Binding | ChEMBL | 614 | 5 | 3 | 5 | 5.1 | O=C1Nc2ccccc2C2(CCN(C(=O)N[C@H](Cc3csc4ccccc34)C(=O)N3CCC(N4CCCCC4)CC3)CC2)N1 | 10.1016/j.bmcl.2012.05.118 | |||
| 24756767 | 80566 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 587 | 5 | 2 | 7 | 3.9 | Cc1cc(CC(CC(=O)N2CCC3(CC2)OC(=O)Nc2ccccc23)C(=O)N2CCC3(CC2)OCCO3)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018510 | 80566 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 587 | 5 | 2 | 7 | 3.9 | Cc1cc(CC(CC(=O)N2CCC3(CC2)OC(=O)Nc2ccccc23)C(=O)N2CCC3(CC2)OCCO3)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL216101 | 216097 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 44403914 | 172999 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 685 | 15 | 5 | 5 | 5.1 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(N)c(Br)c1)NC(=O)CCCc1ccccc1)C(=O)Nc1ccccc1 | 10.1021/jm0490641 | |||
| CHEMBL426646 | 172999 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | 685 | 15 | 5 | 5 | 5.1 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(N)c(Br)c1)NC(=O)CCCc1ccccc1)C(=O)Nc1ccccc1 | 10.1021/jm0490641 | |||
| CHEMBL410450 | 219600 | 0 | None | - | 0 | Human | 4.3 | pIC50 | = | 4.3 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 44323095 | 113738 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 470 | 5 | 1 | 4 | 6.1 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2ccc(C(F)(F)F)cc2)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| CHEMBL314992 | 113738 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 470 | 5 | 1 | 4 | 6.1 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2ccc(C(F)(F)F)cc2)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| 10433192 | 170204 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 436 | 5 | 1 | 4 | 5.7 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2ccc(Cl)cc2)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| CHEMBL419684 | 170204 | 0 | None | - | 0 | Human | 5.3 | pIC50 | = | 5.3 | Binding | ChEMBL | 436 | 5 | 1 | 4 | 5.7 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2ccc(Cl)cc2)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| 44403860 | 147841 | 0 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 853 | 12 | 5 | 10 | 4.3 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2c(O)nc3ccccc32)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| CHEMBL382469 | 147841 | 0 | None | - | 1 | Rat | 7.3 | pIC50 | = | 7.3 | Binding | ChEMBL | 853 | 12 | 5 | 10 | 4.3 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(n2c(O)nc3ccccc32)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| 58864463 | 80473 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 596 | 6 | 2 | 6 | 3.8 | CC(C)(C)OC(=O)N[C@@H](CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCC(N2CCCCC2)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018359 | 80473 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 596 | 6 | 2 | 6 | 3.8 | CC(C)(C)OC(=O)N[C@@H](CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCC(N2CCCCC2)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| 10433192 | 170204 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 436 | 5 | 1 | 4 | 5.7 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2ccc(Cl)cc2)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| CHEMBL419684 | 170204 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | 436 | 5 | 1 | 4 | 5.7 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2ccc(Cl)cc2)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| 44403861 | 78798 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| CHEMBL197529 | 78798 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@@H](NC(=O)[C@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm0490641 | |||
| 70687746 | 80970 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 607 | 7 | 2 | 6 | 6.2 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2c(CN3CCCCC3)n[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2023185 | 80970 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 607 | 7 | 2 | 6 | 6.2 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2c(CN3CCCCC3)n[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 70695974 | 80576 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 643 | 7 | 2 | 5 | 5.1 | Cc1cc(C[C@H](CC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018520 | 80576 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 643 | 7 | 2 | 5 | 5.1 | Cc1cc(C[C@H](CC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2369458 | 216395 | 0 | None | - | 0 | Rat | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| 70685594 | 80972 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 593 | 7 | 2 | 6 | 5.8 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2c(CN3CCCC3)n[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2023187 | 80972 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | 593 | 7 | 2 | 6 | 5.8 | Cc1cc(CC(OC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2c(CN3CCCC3)n[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2369458 | 216395 | 0 | None | - | 0 | Human | 8.2 | pIC50 | = | 8.2 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| CHEMBL265906 | 217448 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | None | None | None | CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)[C@@H](C)O)C(=O)NCC(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm970533r | |||||
| CHEMBL386824 | 219175 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL415812 | 219981 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 11753024 | 81152 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 538 | 7 | 3 | 5 | 4.5 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc(CO)cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024588 | 81152 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 538 | 7 | 3 | 5 | 4.5 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccc(CO)cn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 58864272 | 80468 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 587 | 8 | 2 | 6 | 3.4 | O=C(C[C@H](NCc1ccccn1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018354 | 80468 | 0 | None | - | 0 | Human | 6.2 | pIC50 | = | 6.2 | Binding | ChEMBL | 587 | 8 | 2 | 6 | 3.4 | O=C(C[C@H](NCc1ccccn1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL428096 | 220190 | 0 | None | - | 0 | Human | 5.2 | pIC50 | = | 5.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL266666 | 217471 | 0 | None | - | 0 | Human | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 44403855 | 79249 | 0 | None | - | 1 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 787 | 15 | 5 | 8 | 3.7 | COc1cccc(CCNC(=O)N[C@@H](Cc2cc(Br)c(O)c(Br)c2)C(=O)N[C@H](CCCCN)C(=O)N2CCN(c3ccncc3)CC2)c1 | 10.1021/jm0490641 | |||
| CHEMBL198925 | 79249 | 0 | None | - | 1 | Rat | 4.2 | pIC50 | = | 4.2 | Binding | ChEMBL | 787 | 15 | 5 | 8 | 3.7 | COc1cccc(CCNC(=O)N[C@@H](Cc2cc(Br)c(O)c(Br)c2)C(=O)N[C@H](CCCCN)C(=O)N2CCN(c3ccncc3)CC2)c1 | 10.1021/jm0490641 | |||
| 58864421 | 80553 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 629 | 7 | 3 | 9 | 2.7 | Cc1nc(N[C@@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)nc2nn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018497 | 80553 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 629 | 7 | 3 | 9 | 2.7 | Cc1nc(N[C@@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)nc2nn[nH]c12 | 10.1016/j.bmcl.2012.02.066 | |||
| 44323341 | 213239 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 446 | 5 | 1 | 6 | 4.8 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2ccc3c(c2)OCO3)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| CHEMBL88111 | 213239 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | 446 | 5 | 1 | 6 | 4.8 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2ccc3c(c2)OCO3)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| CHEMBL2369458 | 216395 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| 11432183 | 81073 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 508 | 6 | 2 | 4 | 5.0 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL2024170 | 81073 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 508 | 6 | 2 | 4 | 5.0 | Cc1cc(CC(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)c2ccccn2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 58864325 | 80552 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 648 | 8 | 3 | 10 | 3.0 | Cc1nc(N[C@@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)nc(N)c1[N+](=O)[O-] | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018496 | 80552 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 648 | 8 | 3 | 10 | 3.0 | Cc1nc(N[C@@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)nc(N)c1[N+](=O)[O-] | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL265399 | 217424 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| CHEMBL410354 | 219593 | 0 | None | - | 0 | Human | 4.1 | pIC50 | = | 4.1 | Binding | ChEMBL | None | None | None | CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](N)Cc1ccc(O)cc1)C(C)C)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm970533r | |||||
| 70686454 | 83284 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 632 | 6 | 2 | 6 | 4.9 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC2(CC1)N=C(C1CCCCC1)NC2=O | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL2059902 | 83284 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | 632 | 6 | 2 | 6 | 4.9 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC2(CC1)N=C(C1CCCCC1)NC2=O | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL275984 | 217603 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 70692761 | 83281 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 628 | 5 | 2 | 6 | 4.7 | CN1c2ccccc2C(=O)NC12CCN(C(=O)N[C@H](Cc1csc3ccccc13)C(=O)N1CCC(N3CCCCC3)CC1)CC2 | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL2059899 | 83281 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 628 | 5 | 2 | 6 | 4.7 | CN1c2ccccc2C(=O)NC12CCN(C(=O)N[C@H](Cc1csc3ccccc13)C(=O)N1CCC(N3CCCCC3)CC1)CC2 | 10.1016/j.bmcl.2012.05.118 | |||
| 10483468 | 80571 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 586 | 6 | 2 | 6 | 3.5 | O=C(CC(Cc1ccc2[nH]ncc2c1)C(=O)N1CCC2(CC1)OCCO2)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018515 | 80571 | 0 | None | - | 0 | Human | 7.1 | pIC50 | = | 7.1 | Binding | ChEMBL | 586 | 6 | 2 | 6 | 3.5 | O=C(CC(Cc1ccc2[nH]ncc2c1)C(=O)N1CCC2(CC1)OCCO2)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| 70695973 | 80556 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 623 | 7 | 2 | 6 | 4.9 | O=C(C[C@H](Nc1cccc2ncccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018500 | 80556 | 0 | None | - | 0 | Human | 6.1 | pIC50 | = | 6.1 | Binding | ChEMBL | 623 | 7 | 2 | 6 | 4.9 | O=C(C[C@H](Nc1cccc2ncccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2369452 | 216392 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| CHEMBL2369452 | 216392 | 0 | None | - | 0 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm00090a003 | |||||
| 70694802 | 83275 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 614 | 6 | 2 | 6 | 5.0 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL2059880 | 83275 | 0 | None | - | 1 | Human | 8.1 | pIC50 | = | 8.1 | Binding | ChEMBL | 614 | 6 | 2 | 6 | 5.0 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.118 | |||
| CHEMBL407697 | 219458 | 0 | None | - | 0 | Human | 5.1 | pIC50 | = | 5.1 | Binding | ChEMBL | None | None | None | CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm970533r | |||||
| CHEMBL2371144 | 216795 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6.0 | Binding | ChEMBL | None | None | None | CC(C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)[C@@H](C)O)C(=O)NCC(=O)N1CCCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O | 10.1021/jm970533r | |||||
| CHEMBL269517 | 217573 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | None | None | None | None | 10.1021/jm970533r | |||||
| 44323110 | 113926 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 402 | 5 | 1 | 4 | 5.1 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2ccccc2)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| CHEMBL316211 | 113926 | 0 | None | - | 0 | Human | 4.0 | pIC50 | = | 4.0 | Binding | ChEMBL | 402 | 5 | 1 | 4 | 5.1 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2ccccc2)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| 58864368 | 80544 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 683 | 7 | 3 | 5 | 5.4 | O=C(Nc1cccc(Cl)c1Cl)N[C@@H](CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCC(N2CCCCC2)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018488 | 80544 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 683 | 7 | 3 | 5 | 5.4 | O=C(Nc1cccc(Cl)c1Cl)N[C@@H](CC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCC(N2CCCCC2)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| 58864250 | 80548 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 608 | 7 | 2 | 7 | 3.8 | O=C(C[C@H](Nc1cc(Cl)ncn1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| CHEMBL2018492 | 80548 | 0 | None | - | 0 | Human | 7.0 | pIC50 | = | 7.0 | Binding | ChEMBL | 608 | 7 | 2 | 7 | 3.8 | O=C(C[C@H](Nc1cc(Cl)ncn1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.02.066 | |||
| 44323180 | 213405 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 470 | 5 | 1 | 4 | 6.1 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2cccc(C(F)(F)F)c2)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| CHEMBL89148 | 213405 | 0 | None | - | 0 | Human | 5.0 | pIC50 | = | 5 | Binding | ChEMBL | 470 | 5 | 1 | 4 | 6.1 | CCC1CN2CCC1CC2[C@H](O)c1cc(-c2cccc(C(F)(F)F)c2)nc2ccc(OC)cc12 | 10.1016/S0960-894X(97)10046-4 | |||
| 56675112 | 70111 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 3187 | 105 | 47 | 49 | -19.7 | CC(C)C[C@H](NC(=O)COCCOCCNC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1016/0960-894X(95)00078-8 | |||
| 91930235 | 70111 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 3187 | 105 | 47 | 49 | -19.7 | CC(C)C[C@H](NC(=O)COCCOCCNC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1016/0960-894X(95)00078-8 | |||
| CHEMBL1794015 | 70111 | 0 | None | - | 0 | Human | 6.0 | pIC50 | = | 6 | Binding | ChEMBL | 3187 | 105 | 47 | 49 | -19.7 | CC(C)C[C@H](NC(=O)COCCOCCNC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)[C@H](C)O)[C@H](C)O)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1016/0960-894X(95)00078-8 | |||
| 6918509 | 83817 | 41 | None | 131 | 2 | Human | 10.4 | pKd | = | 10.4 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm500364u | |||
| CHEMBL207197 | 83817 | 41 | None | 131 | 2 | Human | 10.4 | pKd | = | 10.4 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm500364u | |||
| 6918509 | 83817 | 41 | None | 131 | 2 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm500364u | |||
| CHEMBL207197 | 83817 | 41 | None | 131 | 2 | Human | 10.1 | pKd | = | 10.1 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm500364u | |||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1021/jm500364u | |||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 8.7 | pKd | = | 8.7 | Binding | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1021/jm500364u | |||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1021/jm500364u | |||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 8.4 | pKd | = | 8.4 | Binding | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1021/jm500364u | |||
| 6918509 | 83817 | 41 | None | 131 | 2 | Human | 11.0 | pKi | = | 11 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2013.04.012 | |||
| CHEMBL207197 | 83817 | 41 | None | 131 | 2 | Human | 11.0 | pKi | = | 11 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2013.04.012 | |||
| 6918509 | 83817 | 41 | None | 131 | 2 | Human | 11.0 | pKi | = | 11 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/ml300021s | |||
| CHEMBL207197 | 83817 | 41 | None | 131 | 2 | Human | 11.0 | pKi | = | 11 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/ml300021s | |||
| 6918509 | 83817 | 41 | None | 131 | 2 | Human | 11.0 | pKi | = | 11 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL207197 | 83817 | 41 | None | 131 | 2 | Human | 11.0 | pKi | = | 11 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 11467753 | 180975 | 0 | None | - | 1 | Human | 11.0 | pKi | = | 11 | Binding | ChEMBL | 626 | 6 | 3 | 5 | 4.5 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1021/jm800546t | |||
| CHEMBL454791 | 180975 | 0 | None | - | 1 | Human | 11.0 | pKi | = | 11 | Binding | ChEMBL | 626 | 6 | 3 | 5 | 4.5 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1021/jm800546t | |||
| 10394458 | 94448 | 0 | None | - | 1 | Human | 11.0 | pKi | = | 11.0 | Binding | ChEMBL | 646 | 6 | 3 | 5 | 4.8 | O=C(NC(Cc1cc(Cl)c2[nH]ncc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.01.011 | |||
| CHEMBL2336422 | 94448 | 0 | None | - | 1 | Human | 11.0 | pKi | = | 11.0 | Binding | ChEMBL | 646 | 6 | 3 | 5 | 4.8 | O=C(NC(Cc1cc(Cl)c2[nH]ncc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.01.011 | |||
| 10077700 | 94450 | 0 | None | - | 1 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 626 | 6 | 3 | 5 | 4.5 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.01.011 | |||
| CHEMBL2336424 | 94450 | 0 | None | - | 1 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 626 | 6 | 3 | 5 | 4.5 | Cc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.01.011 | |||
| 44593666 | 179509 | 7 | None | - | 1 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 644 | 6 | 3 | 5 | 4.6 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1021/jm800546t | |||
| CHEMBL450668 | 179509 | 7 | None | - | 1 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 644 | 6 | 3 | 5 | 4.6 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1021/jm800546t | |||
| 44593666 | 179509 | 7 | None | - | 1 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 644 | 6 | 3 | 5 | 4.6 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.04.012 | |||
| CHEMBL450668 | 179509 | 7 | None | - | 1 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 644 | 6 | 3 | 5 | 4.6 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.04.012 | |||
| 44593666 | 179509 | 7 | None | - | 1 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 644 | 6 | 3 | 5 | 4.6 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.01.011 | |||
| CHEMBL450668 | 179509 | 7 | None | - | 1 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 644 | 6 | 3 | 5 | 4.6 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.01.011 | |||
| 44593666 | 179509 | 7 | None | - | 1 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 644 | 6 | 3 | 5 | 4.6 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| CHEMBL450668 | 179509 | 7 | None | - | 1 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 644 | 6 | 3 | 5 | 4.6 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2012.02.065 | |||
| 6918509 | 83817 | 41 | None | 131 | 2 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm500364u | |||
| CHEMBL207197 | 83817 | 41 | None | 131 | 2 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm500364u | |||
| 6918509 | 83817 | 41 | None | 131 | 2 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2012.04.105 | |||
| CHEMBL207197 | 83817 | 41 | None | 131 | 2 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2012.04.105 | |||
| 164614302 | 192121 | 0 | None | - | 1 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 646 | 5 | 2 | 5 | 4.5 | CCn1c(=O)[nH]c2c(Cl)cc3c(c21)CN(CC(F)(F)F)C(=O)[C@H](CC(=O)N1CCC(N2CCc4ccccc4NC2=O)CC1)C3 | 10.1016/j.bmcl.2021.128077 | |||
| CHEMBL4859941 | 192121 | 0 | None | - | 1 | Human | 10.9 | pKi | = | 10.9 | Binding | ChEMBL | 646 | 5 | 2 | 5 | 4.5 | CCn1c(=O)[nH]c2c(Cl)cc3c(c21)CN(CC(F)(F)F)C(=O)[C@H](CC(=O)N1CCC(N2CCc4ccccc4NC2=O)CC1)C3 | 10.1016/j.bmcl.2021.128077 | |||
| 71569533 | 94438 | 0 | None | - | 1 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 627 | 6 | 3 | 6 | 3.9 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2nn[nH]c12 | 10.1016/j.bmcl.2013.01.011 | |||
| CHEMBL2336411 | 94438 | 0 | None | - | 1 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 627 | 6 | 3 | 6 | 3.9 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2nn[nH]c12 | 10.1016/j.bmcl.2013.01.011 | |||
| 164618286 | 191324 | 0 | None | - | 1 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 632 | 4 | 2 | 5 | 4.1 | Cn1c(=O)[nH]c2c(Cl)cc3c(c21)CN(CC(F)(F)F)C(=O)[C@H](CC(=O)N1CCC(N2CCc4ccccc4NC2=O)CC1)C3 | 10.1016/j.bmcl.2021.128077 | |||
| CHEMBL4848032 | 191324 | 0 | None | - | 1 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 632 | 4 | 2 | 5 | 4.1 | Cn1c(=O)[nH]c2c(Cl)cc3c(c21)CN(CC(F)(F)F)C(=O)[C@H](CC(=O)N1CCC(N2CCc4ccccc4NC2=O)CC1)C3 | 10.1016/j.bmcl.2021.128077 | |||
| 73356952 | 99254 | 0 | None | - | 1 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 586 | 4 | 2 | 6 | 3.7 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(CC(=O)Nc2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | |||
| CHEMBL2431249 | 99254 | 0 | None | - | 1 | Human | 10.8 | pKi | = | 10.8 | Binding | ChEMBL | 586 | 4 | 2 | 6 | 3.7 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(CC(=O)Nc2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | |||
| 44469664 | 99251 | 0 | None | - | 1 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 567 | 2 | 1 | 5 | 4.1 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(CC#Cc2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | |||
| CHEMBL2431246 | 99251 | 0 | None | - | 1 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 567 | 2 | 1 | 5 | 4.1 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(CC#Cc2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | |||
| 164617750 | 191349 | 0 | None | - | 1 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 618 | 4 | 3 | 4 | 4.0 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]c(=O)[nH]c3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| CHEMBL4848486 | 191349 | 0 | None | - | 1 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 618 | 4 | 3 | 4 | 4.0 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]c(=O)[nH]c3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| 59555187 | 111957 | 0 | None | - | 1 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 692 | 8 | 1 | 6 | 6.2 | CC(C)N1CCN(c2c(F)cccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114495 | 111957 | 0 | None | - | 1 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 692 | 8 | 1 | 6 | 6.2 | CC(C)N1CCN(c2c(F)cccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 164614208 | 191983 | 0 | None | - | 1 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 700 | 5 | 2 | 5 | 5.1 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]c(=O)n(CC(F)(F)F)c3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| CHEMBL4857649 | 191983 | 0 | None | - | 1 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 700 | 5 | 2 | 5 | 5.1 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]c(=O)n(CC(F)(F)F)c3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| 25019940 | 74724 | 33 | None | 478 | 2 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 557 | 4 | 3 | 5 | 3.8 | O=C(CN1C(=O)C2(CCCC2)NC[C@H]1c1cc(F)cc(F)c1)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2013.04.012 | |||
| CHEMBL1910936 | 74724 | 33 | None | 478 | 2 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 557 | 4 | 3 | 5 | 3.8 | O=C(CN1C(=O)C2(CCCC2)NC[C@H]1c1cc(F)cc(F)c1)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2013.04.012 | |||
| 25019940 | 74724 | 33 | None | 478 | 2 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 557 | 4 | 3 | 5 | 3.8 | O=C(CN1C(=O)C2(CCCC2)NC[C@H]1c1cc(F)cc(F)c1)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1021/ml400199p | |||
| CHEMBL1910936 | 74724 | 33 | None | 478 | 2 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 557 | 4 | 3 | 5 | 3.8 | O=C(CN1C(=O)C2(CCCC2)NC[C@H]1c1cc(F)cc(F)c1)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1021/ml400199p | |||
| 44469946 | 99258 | 0 | None | - | 1 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 569 | 4 | 1 | 5 | 4.8 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(C/C=C/c2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | |||
| CHEMBL2431253 | 99258 | 0 | None | - | 1 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 569 | 4 | 1 | 5 | 4.8 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(C/C=C/c2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | |||
| 57977594 | 99261 | 0 | None | - | 1 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 545 | 4 | 2 | 5 | 3.6 | CN1C[C@@H](c2cc(F)cc(F)c2)N(CC(=O)Nc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C1(C)C | 10.1021/ml400199p | |||
| CHEMBL2431256 | 99261 | 0 | None | - | 1 | Human | 10.7 | pKi | = | 10.7 | Binding | ChEMBL | 545 | 4 | 2 | 5 | 3.6 | CN1C[C@@H](c2cc(F)cc(F)c2)N(CC(=O)Nc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C1(C)C | 10.1021/ml400199p | |||
| 11377534 | 94443 | 0 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 707 | 6 | 3 | 6 | 4.5 | O=C(N[C@H](Cc1cc(Br)c2[nH]c(=O)oc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.01.011 | |||
| CHEMBL2336416 | 94443 | 0 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 707 | 6 | 3 | 6 | 4.5 | O=C(N[C@H](Cc1cc(Br)c2[nH]c(=O)oc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.01.011 | |||
| 53472683 | 97831 | 11 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 638 | 6 | 3 | 6 | 3.5 | Cc1cc(C[C@@H](NC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCN(C3CCN(C)CC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.04.012 | |||
| CHEMBL2397415 | 97831 | 11 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 638 | 6 | 3 | 6 | 3.5 | Cc1cc(C[C@@H](NC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C(=O)N2CCN(C3CCN(C)CC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.04.012 | |||
| 46885183 | 15110 | 0 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 488 | 2 | 2 | 7 | 2.7 | O=C1Cn2c(=O)n(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)Nc4ncccc43)c3cccc(c32)N1 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1092882 | 15110 | 0 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 488 | 2 | 2 | 7 | 2.7 | O=C1Cn2c(=O)n(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)Nc4ncccc43)c3cccc(c32)N1 | 10.1016/j.bmcl.2010.02.086 | |||
| 164628650 | 193138 | 0 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 673 | 5 | 2 | 7 | 3.9 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]c(=O)n(CC(F)(F)F)c3c2CN(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| CHEMBL4875327 | 193138 | 0 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 673 | 5 | 2 | 7 | 3.9 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]c(=O)n(CC(F)(F)F)c3c2CN(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| 51049968 | 89335 | 47 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 534 | 3 | 2 | 7 | 4.5 | N[C@@H]1c2cccnc2[C@H](OC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)CC[C@H]1c1cccc(F)c1F | 10.1021/jm3013147 | |||
| CHEMBL2178422 | 89335 | 47 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | 534 | 3 | 2 | 7 | 4.5 | N[C@@H]1c2cccnc2[C@H](OC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)CC[C@H]1c1cccc(F)c1F | 10.1021/jm3013147 | |||
| CHEMBL2369459 | 216396 | 0 | None | - | 1 | Human | 10.6 | pKi | = | 10.6 | Binding | ChEMBL | None | None | None | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](C)N)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C | 10.1021/jm8007618 | |||||
| 76321477 | 111982 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 706 | 7 | 1 | 6 | 6.6 | CC(C)(C)CCN1C(=O)[C@H](CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)S[C@@H]1c1cccc(F)c1N1CCN(C(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114676 | 111982 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 706 | 7 | 1 | 6 | 6.6 | CC(C)(C)CCN1C(=O)[C@H](CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)S[C@@H]1c1cccc(F)c1N1CCN(C(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 71569375 | 94445 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 660 | 6 | 3 | 5 | 5.1 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)c(Cl)c2cn[nH]c12 | 10.1016/j.bmcl.2013.01.011 | |||
| CHEMBL2336418 | 94445 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 660 | 6 | 3 | 5 | 5.1 | Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)c(Cl)c2cn[nH]c12 | 10.1016/j.bmcl.2013.01.011 | |||
| 25019993 | 99259 | 1 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 531 | 4 | 3 | 5 | 3.2 | CC1(C)NC[C@@H](c2cc(F)cc(F)c2)N(CC(=O)Nc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C1=O | 10.1021/ml400199p | |||
| CHEMBL2431254 | 99259 | 1 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 531 | 4 | 3 | 5 | 3.2 | CC1(C)NC[C@@H](c2cc(F)cc(F)c2)N(CC(=O)Nc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C1=O | 10.1021/ml400199p | |||
| 45485692 | 205779 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 530 | 4 | 2 | 4 | 4.7 | CC1(C)CC[C@@H](c2c(F)cccc2F)N(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)Nc3ncccc32)C1=O | 10.1016/j.bmcl.2009.07.134 | |||
| CHEMBL585568 | 205779 | 0 | None | - | 1 | Human | 10.5 | pKi | = | 10.5 | Binding | ChEMBL | 530 | 4 | 2 | 4 | 4.7 | CC1(C)CC[C@@H](c2c(F)cccc2F)N(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)Nc3ncccc32)C1=O | 10.1016/j.bmcl.2009.07.134 | |||
| 54581910 | 68290 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 592 | 3 | 2 | 7 | 5.5 | CC1(c2cnc3n2C[C@H](c2cccc(F)c2F)CC[C@H]3NC(=O)N2CCC3(CC2)OC(=O)Nc2ncccc23)CCCO1 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770729 | 68290 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 592 | 3 | 2 | 7 | 5.5 | CC1(c2cnc3n2C[C@H](c2cccc(F)c2F)CC[C@H]3NC(=O)N2CCC3(CC2)OC(=O)Nc2ncccc23)CCCO1 | 10.1016/j.bmcl.2010.12.054 | |||
| 52940673 | 24935 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 530 | 4 | 1 | 4 | 5.7 | CC(C)(C)C(=O)N(Cc1cnc2cc3c(cc2c1)C[C@@]1(C3)C(=O)Nc2ncccc21)C[C@@H]1CCc2ccccc21 | 10.1016/j.bmcl.2010.08.105 | |||
| CHEMBL1269644 | 24935 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 530 | 4 | 1 | 4 | 5.7 | CC(C)(C)C(=O)N(Cc1cnc2cc3c(cc2c1)C[C@@]1(C3)C(=O)Nc2ncccc21)C[C@@H]1CCc2ccccc21 | 10.1016/j.bmcl.2010.08.105 | |||
| 11204595 | 94444 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 663 | 6 | 3 | 6 | 4.4 | O=C(N[C@H](Cc1cc(Cl)c2[nH]c(=O)oc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.01.011 | |||
| CHEMBL2336417 | 94444 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 663 | 6 | 3 | 6 | 4.4 | O=C(N[C@H](Cc1cc(Cl)c2[nH]c(=O)oc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.01.011 | |||
| 54586725 | 68289 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 608 | 6 | 2 | 7 | 6.1 | CCC(CC)(OC)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770728 | 68289 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 608 | 6 | 2 | 7 | 6.1 | CCC(CC)(OC)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| 25181509 | 196144 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 480 | 3 | 3 | 7 | 1.8 | O=C(Cn1c(=O)n2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | |||
| CHEMBL512773 | 196144 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 480 | 3 | 3 | 7 | 1.8 | O=C(Cn1c(=O)n2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | |||
| 54585731 | 68276 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 579 | 5 | 2 | 7 | 4.7 | COC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770715 | 68276 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 579 | 5 | 2 | 7 | 4.7 | COC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| 57977652 | 81861 | 0 | None | 85 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 571 | 4 | 3 | 5 | 3.9 | C[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1021/ml400199p | |||
| CHEMBL2035981 | 81861 | 0 | None | 85 | 2 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 571 | 4 | 3 | 5 | 3.9 | C[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1021/ml400199p | |||
| 25181509 | 196144 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 480 | 3 | 3 | 7 | 1.8 | O=C(Cn1c(=O)n2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL512773 | 196144 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 480 | 3 | 3 | 7 | 1.8 | O=C(Cn1c(=O)n2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | |||
| 25181509 | 196144 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 480 | 3 | 3 | 7 | 1.8 | O=C(Cn1c(=O)n2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL512773 | 196144 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 480 | 3 | 3 | 7 | 1.8 | O=C(Cn1c(=O)n2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2010.02.086 | |||
| 44631920 | 132617 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 534 | 7 | 1 | 4 | 5.3 | C[C@H](c1cc(F)cc(F)c1)N(C/C=C/c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21)C(=O)C(C)(C)CF | nan | |||
| CHEMBL3648345 | 132617 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 534 | 7 | 1 | 4 | 5.3 | C[C@H](c1cc(F)cc(F)c1)N(C/C=C/c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21)C(=O)C(C)(C)CF | nan | |||
| 164627356 | 193064 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 633 | 4 | 2 | 6 | 3.5 | Cn1c(=O)[nH]c2c(Cl)cc3c(c21)CN(CC(F)(F)F)C(=O)[C@H](CC(=O)N1CCC(N2CCc4ncccc4NC2=O)CC1)C3 | 10.1016/j.bmcl.2021.128077 | |||
| CHEMBL4874157 | 193064 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 633 | 4 | 2 | 6 | 3.5 | Cn1c(=O)[nH]c2c(Cl)cc3c(c21)CN(CC(F)(F)F)C(=O)[C@H](CC(=O)N1CCC(N2CCc4ncccc4NC2=O)CC1)C3 | 10.1016/j.bmcl.2021.128077 | |||
| 44470090 | 99256 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 571 | 5 | 1 | 5 | 4.7 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(CCCc2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | |||
| CHEMBL2431251 | 99256 | 0 | None | - | 1 | Human | 10.4 | pKi | = | 10.4 | Binding | ChEMBL | 571 | 5 | 1 | 5 | 4.7 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(CCCc2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | |||
| 50939479 | 99253 | 1 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 585 | 4 | 2 | 5 | 4.3 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(CC(=O)Nc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | |||
| CHEMBL2431248 | 99253 | 1 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 585 | 4 | 2 | 5 | 4.3 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(CC(=O)Nc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | |||
| 17751102 | 186718 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 602 | 4 | 2 | 4 | 4.8 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| CHEMBL4746351 | 186718 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 602 | 4 | 2 | 4 | 4.8 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| 58864297 | 94446 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 654 | 7 | 3 | 5 | 5.0 | CCc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2c(C)n[nH]c12 | 10.1016/j.bmcl.2013.01.011 | |||
| CHEMBL2336419 | 94446 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 654 | 7 | 3 | 5 | 5.0 | CCc1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2c(C)n[nH]c12 | 10.1016/j.bmcl.2013.01.011 | |||
| 54580850 | 68285 | 1 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 580 | 4 | 2 | 7 | 5.3 | COC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770724 | 68285 | 1 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 580 | 4 | 2 | 7 | 5.3 | COC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| 54583843 | 68287 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 594 | 5 | 2 | 7 | 5.7 | CCOC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770726 | 68287 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 594 | 5 | 2 | 7 | 5.7 | CCOC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| 58379673 | 111095 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 568 | 6 | 1 | 4 | 5.7 | C[C@H](c1cc(F)cc(F)c1)N(C/C=C/c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21)C(=O)C1(C(F)(F)F)CC1 | nan | |||
| CHEMBL3099925 | 111095 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 568 | 6 | 1 | 4 | 5.7 | C[C@H](c1cc(F)cc(F)c1)N(C/C=C/c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21)C(=O)C1(C(F)(F)F)CC1 | nan | |||
| 56944164 | 81863 | 3 | None | 194 | 4 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 572 | 4 | 3 | 6 | 3.3 | C[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | |||
| CHEMBL2035983 | 81863 | 3 | None | 194 | 4 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 572 | 4 | 3 | 6 | 3.3 | C[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | |||
| 11388586 | 94442 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 755 | 6 | 3 | 6 | 4.3 | O=C(N[C@H](Cc1cc(I)c2[nH]c(=O)oc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.01.011 | |||
| CHEMBL2336415 | 94442 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 755 | 6 | 3 | 6 | 4.3 | O=C(N[C@H](Cc1cc(I)c2[nH]c(=O)oc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.01.011 | |||
| 50939608 | 99252 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 559 | 4 | 2 | 5 | 3.8 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(CC(=O)Nc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C1(C)C | 10.1021/ml400199p | |||
| CHEMBL2431247 | 99252 | 0 | None | - | 1 | Human | 10.3 | pKi | = | 10.3 | Binding | ChEMBL | 559 | 4 | 2 | 5 | 3.8 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(CC(=O)Nc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C1(C)C | 10.1021/ml400199p | |||
| 44631936 | 131957 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 557 | 3 | 1 | 5 | 5.0 | CC(C)N1C(=O)N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)C2(CCCc3ccccc32)C1=O | nan | |||
| CHEMBL3645137 | 131957 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 557 | 3 | 1 | 5 | 5.0 | CC(C)N1C(=O)N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)C2(CCCc3ccccc32)C1=O | nan | |||
| 164619429 | 192849 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 599 | 4 | 2 | 6 | 4.0 | N#Cc1c[nH]c2c(Cl)cc3c(c12)CN(CC(F)(F)F)C(=O)[C@H](CC(=O)N1CCC(n2c(=O)[nH]c4ncccc42)CC1)C3 | 10.1016/j.bmcl.2021.128077 | |||
| CHEMBL4871223 | 192849 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 599 | 4 | 2 | 6 | 4.0 | N#Cc1c[nH]c2c(Cl)cc3c(c12)CN(CC(F)(F)F)C(=O)[C@H](CC(=O)N1CCC(n2c(=O)[nH]c4ncccc42)CC1)C3 | 10.1016/j.bmcl.2021.128077 | |||
| 164627588 | 193079 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 626 | 4 | 2 | 4 | 5.2 | N#Cc1c[nH]c2c(Cl)cc3c(c12)CN(CC(F)(F)F)C(=O)[C@H](CC(=O)N1CCC(N2CCc4ccccc4NC2=O)CC1)C3 | 10.1016/j.bmcl.2021.128077 | |||
| CHEMBL4874451 | 193079 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 626 | 4 | 2 | 4 | 5.2 | N#Cc1c[nH]c2c(Cl)cc3c(c12)CN(CC(F)(F)F)C(=O)[C@H](CC(=O)N1CCC(N2CCc4ccccc4NC2=O)CC1)C3 | 10.1016/j.bmcl.2021.128077 | |||
| 46179077 | 131963 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 593 | 3 | 1 | 5 | 5.4 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | nan | |||
| CHEMBL3645143 | 131963 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 593 | 3 | 1 | 5 | 5.4 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | nan | |||
| 58379669 | 132616 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 550 | 7 | 1 | 4 | 5.6 | C[C@H](c1cc(F)cc(F)c1)N(C/C=C/c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21)C(=O)C(C)(C)CCl | nan | |||
| CHEMBL3648344 | 132616 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 550 | 7 | 1 | 4 | 5.6 | C[C@H](c1cc(F)cc(F)c1)N(C/C=C/c1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21)C(=O)C(C)(C)CCl | nan | |||
| 51357856 | 89333 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 560 | 4 | 1 | 7 | 5.8 | [N-]=[N+]=N[C@@H]1c2cccnc2[C@H](OC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)CC[C@H]1c1cccc(F)c1F | 10.1021/jm3013147 | |||
| CHEMBL2178420 | 89333 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 560 | 4 | 1 | 7 | 5.8 | [N-]=[N+]=N[C@@H]1c2cccnc2[C@H](OC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)CC[C@H]1c1cccc(F)c1F | 10.1021/jm3013147 | |||
| 164620407 | 193006 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 653 | 4 | 2 | 4 | 4.9 | O=C(C[C@@H]1Cc2cc(Cl)c3c(c2CN(CC(F)(F)F)C1=O)C(F)(F)C(=O)N3)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| CHEMBL4873378 | 193006 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 653 | 4 | 2 | 4 | 4.9 | O=C(C[C@@H]1Cc2cc(Cl)c3c(c2CN(CC(F)(F)F)C1=O)C(F)(F)C(=O)N3)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| 46174937 | 83356 | 7 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 519 | 3 | 1 | 6 | 5.0 | O=C(O[C@@H]1CC[C@@H](c2cccc(F)c2F)Cc2cccnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/ml300021s | |||
| CHEMBL2063115 | 83356 | 7 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 519 | 3 | 1 | 6 | 5.0 | O=C(O[C@@H]1CC[C@@H](c2cccc(F)c2F)Cc2cccnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/ml300021s | |||
| 11706981 | 68281 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 590 | 3 | 2 | 6 | 5.5 | O=C1Nc2ncccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)Cn4c(CC(F)(F)F)cnc43)CC2)O1 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770720 | 68281 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 590 | 3 | 2 | 6 | 5.5 | O=C1Nc2ncccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)Cn4c(CC(F)(F)F)cnc43)CC2)O1 | 10.1016/j.bmcl.2010.12.054 | |||
| 59555031 | 111956 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 678 | 8 | 1 | 6 | 5.8 | CCN1CCN(c2c(F)cccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114494 | 111956 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 678 | 8 | 1 | 6 | 5.8 | CCN1CCN(c2c(F)cccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 57404496 | 80976 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 602 | 6 | 2 | 8 | 4.4 | Cc1cc(CC(OC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c2cc(C(=O)N(C)C)cc(Cl)n2)cc2cn[nH]c12 | 10.1021/ml300021s | |||
| CHEMBL2023191 | 80976 | 0 | None | - | 1 | Human | 10.2 | pKi | = | 10.2 | Binding | ChEMBL | 602 | 6 | 2 | 8 | 4.4 | Cc1cc(CC(OC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c2cc(C(=O)N(C)C)cc(Cl)n2)cc2cn[nH]c12 | 10.1021/ml300021s | |||
| 46885299 | 14980 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 501 | 3 | 2 | 5 | 4.6 | CCC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@@]1(C4)C(=O)Nc3ncccc31)C2 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1092208 | 14980 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 501 | 3 | 2 | 5 | 4.6 | CCC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@@]1(C4)C(=O)Nc3ncccc31)C2 | 10.1016/j.bmcl.2010.02.086 | |||
| 51357585 | 89337 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 535 | 3 | 2 | 7 | 4.5 | O=C(O[C@@H]1CC[C@@H](c2cccc(F)c2F)[C@H](O)c2cccnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm3013147 | |||
| CHEMBL2178424 | 89337 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 535 | 3 | 2 | 7 | 4.5 | O=C(O[C@@H]1CC[C@@H](c2cccc(F)c2F)[C@H](O)c2cccnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm3013147 | |||
| 23658217 | 186716 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 575 | 4 | 2 | 6 | 3.6 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4746329 | 186716 | 0 | None | - | 1 | Human | 10.1 | pKi | = | 10.1 | Binding | ChEMBL | 575 | 4 | 2 | 6 | 3.6 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| 44468576 | 99257 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 568 | 4 | 1 | 4 | 5.4 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(C/C=C/c2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | |||
| CHEMBL2431252 | 99257 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 568 | 4 | 1 | 4 | 5.4 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(C/C=C/c2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | |||
| 17751102 | 186718 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 602 | 4 | 2 | 4 | 4.8 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4746351 | 186718 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 602 | 4 | 2 | 4 | 4.8 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| 59554856 | 111958 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 706 | 7 | 1 | 6 | 6.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)SC1c1cccc(F)c1N1CCN(C(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114496 | 111958 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 706 | 7 | 1 | 6 | 6.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)SC1c1cccc(F)c1N1CCN(C(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 52940932 | 25025 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 504 | 4 | 1 | 4 | 5.8 | C[C@H](c1ccccc1)N(Cc1cnc2cc3c(cc2c1)C[C@@]1(C3)C(=O)Nc2ncccc21)C(=O)C(C)(C)C | 10.1016/j.bmcl.2010.08.105 | |||
| CHEMBL1270291 | 25025 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10 | Binding | ChEMBL | 504 | 4 | 1 | 4 | 5.8 | C[C@H](c1ccccc1)N(Cc1cnc2cc3c(cc2c1)C[C@@]1(C3)C(=O)Nc2ncccc21)C(=O)C(C)(C)C | 10.1016/j.bmcl.2010.08.105 | |||
| 44469523 | 99096 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 566 | 2 | 1 | 4 | 4.7 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(CC#Cc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | |||
| CHEMBL2429882 | 99096 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 566 | 2 | 1 | 4 | 4.7 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(CC#Cc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | |||
| 69747490 | 99260 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 545 | 4 | 3 | 5 | 3.4 | CC1(C)NC[C@@](C)(c2cc(F)cc(F)c2)N(CC(=O)Nc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C1=O | 10.1021/ml400199p | |||
| CHEMBL2431255 | 99260 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 545 | 4 | 3 | 5 | 3.4 | CC1(C)NC[C@@](C)(c2cc(F)cc(F)c2)N(CC(=O)Nc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C1=O | 10.1021/ml400199p | |||
| 52941862 | 24936 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 530 | 4 | 1 | 4 | 5.7 | CC(C)(C)C(=O)N(Cc1ccc2nc3c(cc2c1)C[C@@]1(C3)C(=O)Nc2ncccc21)C[C@@H]1CCc2ccccc21 | 10.1016/j.bmcl.2010.08.105 | |||
| CHEMBL1269645 | 24936 | 0 | None | - | 1 | Human | 10.0 | pKi | = | 10.0 | Binding | ChEMBL | 530 | 4 | 1 | 4 | 5.7 | CC(C)(C)C(=O)N(Cc1ccc2nc3c(cc2c1)C[C@@]1(C3)C(=O)Nc2ncccc21)C[C@@H]1CCc2ccccc21 | 10.1016/j.bmcl.2010.08.105 | |||
| 164625304 | 192984 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 619 | 4 | 2 | 5 | 4.3 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]c(=O)oc3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| CHEMBL4873084 | 192984 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 619 | 4 | 2 | 5 | 4.3 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]c(=O)oc3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| 52942173 | 25041 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 540 | 4 | 1 | 4 | 6.0 | C[C@H](c1cc(F)cc(F)c1)N(Cc1cnc2cc3c(cc2c1)C[C@@]1(C3)C(=O)Nc2ncccc21)C(=O)C(C)(C)C | 10.1016/j.bmcl.2010.08.105 | |||
| CHEMBL1270391 | 25041 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 540 | 4 | 1 | 4 | 6.0 | C[C@H](c1cc(F)cc(F)c1)N(Cc1cnc2cc3c(cc2c1)C[C@@]1(C3)C(=O)Nc2ncccc21)C(=O)C(C)(C)C | 10.1016/j.bmcl.2010.08.105 | |||
| 45267476 | 203063 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 463 | 3 | 3 | 5 | 3.2 | O=C(Cn1cc2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | |||
| CHEMBL562069 | 203063 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 463 | 3 | 3 | 5 | 3.2 | O=C(Cn1cc2c3c(cccc31)NC(=O)C2)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | |||
| 46885244 | 14565 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 487 | 2 | 2 | 5 | 4.2 | CC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@@]1(C4)C(=O)Nc3ncccc31)C2 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1089433 | 14565 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 487 | 2 | 2 | 5 | 4.2 | CC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@@]1(C4)C(=O)Nc3ncccc31)C2 | 10.1016/j.bmcl.2010.02.086 | |||
| 164612132 | 191437 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 626 | 4 | 2 | 6 | 3.7 | O=C(C[C@@H]1Cc2cc(Cl)c3c(c2CN(CC(F)(F)F)C1=O)C(F)(F)C(=O)N3)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| CHEMBL4849710 | 191437 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 626 | 4 | 2 | 6 | 3.7 | O=C(C[C@@H]1Cc2cc(Cl)c3c(c2CN(CC(F)(F)F)C1=O)C(F)(F)C(=O)N3)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| 45485605 | 204433 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 516 | 3 | 3 | 6 | 2.7 | NCC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@]1(C4)C(=O)Nc3ncccc31)C2=O | 10.1016/j.bmcl.2009.07.134 | |||
| CHEMBL570933 | 204433 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 516 | 3 | 3 | 6 | 2.7 | NCC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@]1(C4)C(=O)Nc3ncccc31)C2=O | 10.1016/j.bmcl.2009.07.134 | |||
| 58379682 | 111094 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 512 | 5 | 1 | 4 | 5.6 | Cc1ccc([C@@H](C)N(C/C=C/c2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C(C)(C)C)cc1F | nan | |||
| CHEMBL3099923 | 111094 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 512 | 5 | 1 | 4 | 5.6 | Cc1ccc([C@@H](C)N(C/C=C/c2cnc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C(C)(C)C)cc1F | nan | |||
| 46178994 | 131959 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 565 | 3 | 2 | 5 | 4.9 | O=C1N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)[C@H](c2cc(F)cc(F)c2)CNC12CCCC2 | nan | |||
| CHEMBL3645139 | 131959 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 565 | 3 | 2 | 5 | 4.9 | O=C1N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)[C@H](c2cc(F)cc(F)c2)CNC12CCCC2 | nan | |||
| 11354531 | 94439 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 707 | 6 | 3 | 6 | 4.5 | O=C(N[C@H](Cc1cc2oc(=O)[nH]c2cc1Br)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.01.011 | |||
| CHEMBL2336412 | 94439 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 707 | 6 | 3 | 6 | 4.5 | O=C(N[C@H](Cc1cc2oc(=O)[nH]c2cc1Br)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.01.011 | |||
| 54580803 | 68258 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 589 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770557 | 68258 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 589 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| 54581909 | 68284 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 552 | 4 | 2 | 7 | 4.6 | COCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770723 | 68284 | 0 | None | - | 1 | Human | 9.9 | pKi | = | 9.9 | Binding | ChEMBL | 552 | 4 | 2 | 7 | 4.6 | COCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| 52944286 | 24937 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 531 | 4 | 1 | 5 | 5.1 | CC(C)(C)C(=O)N(Cc1cnc2nc3c(cc2c1)C[C@@]1(C3)C(=O)Nc2ncccc21)C[C@@H]1CCc2ccccc21 | 10.1016/j.bmcl.2010.08.105 | |||
| CHEMBL1269646 | 24937 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 531 | 4 | 1 | 5 | 5.1 | CC(C)(C)C(=O)N(Cc1cnc2nc3c(cc2c1)C[C@@]1(C3)C(=O)Nc2ncccc21)C[C@@H]1CCc2ccccc21 | 10.1016/j.bmcl.2010.08.105 | |||
| 54583844 | 68288 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 648 | 5 | 2 | 7 | 6.3 | CC(C)(OCC(F)(F)F)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770727 | 68288 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 648 | 5 | 2 | 7 | 6.3 | CC(C)(OCC(F)(F)F)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| 164609291 | 191239 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 602 | 4 | 2 | 4 | 4.8 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]cnc3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| CHEMBL4846749 | 191239 | 0 | None | - | 1 | Human | 9.8 | pKi | = | 9.8 | Binding | ChEMBL | 602 | 4 | 2 | 4 | 4.8 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]cnc3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| 54583842 | 68283 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 591 | 3 | 2 | 7 | 4.9 | O=C1Nc2ncccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)Cn4c(CC(F)(F)F)nnc43)CC2)O1 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770722 | 68283 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 591 | 3 | 2 | 7 | 4.9 | O=C1Nc2ncccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)Cn4c(CC(F)(F)F)nnc43)CC2)O1 | 10.1016/j.bmcl.2010.12.054 | |||
| 23656921 | 96997 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 596 | 6 | 2 | 6 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCOC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL238276 | 96997 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 596 | 6 | 2 | 6 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCOC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 44570616 | 196993 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 538 | 5 | 2 | 7 | 2.5 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)Nc3ncccc31)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL517467 | 196993 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 538 | 5 | 2 | 7 | 2.5 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)Nc3ncccc31)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.106 | |||
| 46182711 | 133760 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 583 | 5 | 3 | 5 | 3.8 | O=C(CN1C(=O)C2(CCCC2)NC[C@H]1c1cc(F)cc(F)c1)Nc1ccc2c(c1)CC1(C2)N=C(c2ccccc2)NC1=O | nan | |||
| CHEMBL3655571 | 133760 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 583 | 5 | 3 | 5 | 3.8 | O=C(CN1C(=O)C2(CCCC2)NC[C@H]1c1cc(F)cc(F)c1)Nc1ccc2c(c1)CC1(C2)N=C(c2ccccc2)NC1=O | nan | |||
| 11158071 | 94447 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 654 | 7 | 3 | 5 | 5.3 | CC(C)c1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.01.011 | |||
| CHEMBL2336420 | 94447 | 0 | None | - | 1 | Human | 9.7 | pKi | = | 9.7 | Binding | ChEMBL | 654 | 7 | 3 | 5 | 5.3 | CC(C)c1cc(CC(NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.01.011 | |||
| 11977527 | 186349 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 588 | 4 | 2 | 4 | 4.7 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4741882 | 186349 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 588 | 4 | 2 | 4 | 4.7 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| 24863333 | 180959 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 612 | 6 | 3 | 5 | 4.2 | O=C(N[C@H](Cc1ccc2[nH]ncc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.01.011 | |||
| CHEMBL454751 | 180959 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 612 | 6 | 3 | 5 | 4.2 | O=C(N[C@H](Cc1ccc2[nH]ncc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.01.011 | |||
| 44593545 | 185233 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 474 | 3 | 3 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL466192 | 185233 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 474 | 3 | 3 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2 | 10.1016/j.bmcl.2008.10.106 | |||
| 46905052 | 17190 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 488 | 3 | 2 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2C | 10.1016/j.bmcl.2009.06.057 | |||
| CHEMBL1162991 | 17190 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 488 | 3 | 2 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2C | 10.1016/j.bmcl.2009.06.057 | |||
| 45485687 | 204362 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 512 | 5 | 2 | 4 | 3.6 | C[C@H](c1cc(F)cc(F)c1)N(CC(=O)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)NC(=O)N1C)C(=O)C(C)(C)C | 10.1016/j.bmcl.2009.07.134 | |||
| CHEMBL570474 | 204362 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 512 | 5 | 2 | 4 | 3.6 | C[C@H](c1cc(F)cc(F)c1)N(CC(=O)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)NC(=O)N1C)C(=O)C(C)(C)C | 10.1016/j.bmcl.2009.07.134 | |||
| 24863333 | 180959 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 612 | 6 | 3 | 5 | 4.2 | O=C(N[C@H](Cc1ccc2[nH]ncc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1021/jm800546t | |||
| CHEMBL454751 | 180959 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 612 | 6 | 3 | 5 | 4.2 | O=C(N[C@H](Cc1ccc2[nH]ncc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1021/jm800546t | |||
| 24863332 | 83253 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 629 | 6 | 3 | 6 | 3.7 | O=C(N[C@H](Cc1ccc2[nH]c(=O)oc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059853 | 83253 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 629 | 6 | 3 | 6 | 3.7 | O=C(N[C@H](Cc1ccc2[nH]c(=O)oc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| 46179076 | 131962 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 531 | 4 | 1 | 5 | 4.7 | CC(C)N1C(=O)N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)C(C)(c2ccccc2)C1=O | nan | |||
| CHEMBL3645142 | 131962 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 531 | 4 | 1 | 5 | 4.7 | CC(C)N1C(=O)N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)C(C)(c2ccccc2)C1=O | nan | |||
| 11445240 | 94440 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 663 | 6 | 3 | 6 | 4.4 | O=C(N[C@H](Cc1cc2oc(=O)[nH]c2cc1Cl)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.01.011 | |||
| CHEMBL2336413 | 94440 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 663 | 6 | 3 | 6 | 4.4 | O=C(N[C@H](Cc1cc2oc(=O)[nH]c2cc1Cl)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.01.011 | |||
| 45267481 | 203441 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 479 | 3 | 3 | 5 | 3.1 | CC12CC(=O)Nc3cccc(c31)N(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)Nc3ncccc31)C2 | 10.1016/j.bmcl.2009.06.057 | |||
| CHEMBL564487 | 203441 | 0 | None | - | 1 | Human | 9.6 | pKi | = | 9.6 | Binding | ChEMBL | 479 | 3 | 3 | 5 | 3.1 | CC12CC(=O)Nc3cccc(c31)N(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)Nc3ncccc31)C2 | 10.1016/j.bmcl.2009.06.057 | |||
| 54587762 | 68286 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 566 | 3 | 3 | 7 | 4.7 | CC(C)(O)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770725 | 68286 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 566 | 3 | 3 | 7 | 4.7 | CC(C)(O)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)OC(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| 23654987 | 121244 | 8 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 633 | 6 | 2 | 7 | 3.9 | Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCOCC3)CC2)cc(C)c1O | 10.1021/jm500364u | |||
| CHEMBL3334624 | 121244 | 8 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 633 | 6 | 2 | 7 | 3.9 | Cc1cc(C[C@@H](OC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCOCC3)CC2)cc(C)c1O | 10.1021/jm500364u | |||
| 11364735 | 96484 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 542 | 6 | 2 | 6 | 2.8 | COCCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | |||
| CHEMBL237662 | 96484 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 542 | 6 | 2 | 6 | 2.8 | COCCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | |||
| 46178835 | 25055 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 538 | 3 | 1 | 4 | 5.8 | CC1(C)CC[C@@H](c2cc(F)cc(F)c2)N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)C1=O | 10.1016/j.bmcl.2010.08.105 | |||
| CHEMBL1270484 | 25055 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 538 | 3 | 1 | 4 | 5.8 | CC1(C)CC[C@@H](c2cc(F)cc(F)c2)N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)C1=O | 10.1016/j.bmcl.2010.08.105 | |||
| 46885135 | 14808 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 468 | 2 | 2 | 7 | 1.4 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(Cn4c(=O)n5c6c(cccc64)NC(=O)C5)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1090848 | 14808 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 468 | 2 | 2 | 7 | 1.4 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(Cn4c(=O)n5c6c(cccc64)NC(=O)C5)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| 11979131 | 187439 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 594 | 4 | 2 | 4 | 5.3 | CC(C)(C)CN1Cc2c(cc(Cl)c3[nH]ncc23)C[C@@H](CC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4755081 | 187439 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 594 | 4 | 2 | 4 | 5.3 | CC(C)(C)CN1Cc2c(cc(Cl)c3[nH]ncc23)C[C@@H](CC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| 46178992 | 131958 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 523 | 3 | 1 | 5 | 4.9 | CC(C)N1C(=O)N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)C2(CCCCCC2)C1=O | nan | |||
| CHEMBL3645138 | 131958 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 523 | 3 | 1 | 5 | 4.9 | CC(C)N1C(=O)N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)C2(CCCCCC2)C1=O | nan | |||
| 23582940 | 203381 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 465 | 3 | 3 | 5 | 3.0 | O=C(CN1CC2CC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | |||
| CHEMBL564088 | 203381 | 0 | None | - | 1 | Human | 9.5 | pKi | = | 9.5 | Binding | ChEMBL | 465 | 3 | 3 | 5 | 3.0 | O=C(CN1CC2CC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | |||
| 54580838 | 68275 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 551 | 5 | 2 | 7 | 4.0 | COCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770714 | 68275 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 551 | 5 | 2 | 7 | 4.0 | COCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| 54586710 | 68280 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 564 | 4 | 2 | 6 | 4.8 | COC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770719 | 68280 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 564 | 4 | 2 | 6 | 4.8 | COC(C)(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| 164626848 | 193279 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 617 | 5 | 3 | 6 | 3.3 | NC(=O)c1c[nH]c2c(Cl)cc3c(c12)CN(CC(F)(F)F)C(=O)[C@H](CC(=O)N1CCC(n2c(=O)[nH]c4ncccc42)CC1)C3 | 10.1016/j.bmcl.2021.128077 | |||
| CHEMBL4877386 | 193279 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 617 | 5 | 3 | 6 | 3.3 | NC(=O)c1c[nH]c2c(Cl)cc3c(c12)CN(CC(F)(F)F)C(=O)[C@H](CC(=O)N1CCC(n2c(=O)[nH]c4ncccc42)CC1)C3 | 10.1016/j.bmcl.2021.128077 | |||
| 11979011 | 187484 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 576 | 4 | 2 | 4 | 5.2 | CC(C)(C)CN1Cc2c(cc(Cl)c3[nH]ncc23)C[C@@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4755588 | 187484 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 576 | 4 | 2 | 4 | 5.2 | CC(C)(C)CN1Cc2c(cc(Cl)c3[nH]ncc23)C[C@@H](CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| 46885185 | 14741 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 502 | 2 | 1 | 7 | 2.8 | CN1C(=O)Cn2c(=O)n(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)Nc4ncccc43)c3cccc1c32 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1090515 | 14741 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 502 | 2 | 1 | 7 | 2.8 | CN1C(=O)Cn2c(=O)n(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)Nc4ncccc43)c3cccc1c32 | 10.1016/j.bmcl.2010.02.086 | |||
| 58379670 | 132618 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 495 | 5 | 1 | 3 | 4.6 | C[C@H](c1cc(F)cc(F)c1)N(C/C=C/c1ccc2c(c1)C[C@@]1(C2)C(=O)NC(=O)N1C)C(=O)C(C)(C)C | nan | |||
| CHEMBL3648346 | 132618 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 495 | 5 | 1 | 3 | 4.6 | C[C@H](c1cc(F)cc(F)c1)N(C/C=C/c1ccc2c(c1)C[C@@]1(C2)C(=O)NC(=O)N1C)C(=O)C(C)(C)C | nan | |||
| 164612882 | 191683 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 603 | 4 | 2 | 5 | 4.1 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]nnc3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| CHEMBL4853137 | 191683 | 0 | None | - | 1 | Human | 9.4 | pKi | = | 9.4 | Binding | ChEMBL | 603 | 4 | 2 | 5 | 4.1 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]nnc3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| 54584803 | 68282 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 575 | 3 | 2 | 6 | 4.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)nnc21)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770721 | 68282 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 575 | 3 | 2 | 6 | 4.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)nnc21)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| 46179163 | 131964 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 579 | 3 | 2 | 5 | 5.3 | O=C1N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)[C@H](c2cc(F)cc(F)c2)CCNC12CCCC2 | nan | |||
| CHEMBL3645144 | 131964 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 579 | 3 | 2 | 5 | 5.3 | O=C1N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)[C@H](c2cc(F)cc(F)c2)CCNC12CCCC2 | nan | |||
| 44468711 | 99255 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 570 | 5 | 1 | 4 | 5.3 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(CCCc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | |||
| CHEMBL2431250 | 99255 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 570 | 5 | 1 | 4 | 5.3 | CN1C[C@@](C)(c2cc(F)cc(F)c2)N(CCCc2ccc3c(c2)C[C@@]2(C3)C(=O)Nc3ncccc32)C(=O)C12CCCC2 | 10.1021/ml400199p | |||
| 23657089 | 153758 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 597 | 6 | 2 | 7 | 2.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCN2CCOCC2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL392634 | 153758 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 597 | 6 | 2 | 7 | 2.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCN2CCOCC2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 11192602 | 153763 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 590 | 6 | 2 | 7 | 2.2 | CS(=O)(=O)CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | |||
| CHEMBL392636 | 153763 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 590 | 6 | 2 | 7 | 2.2 | CS(=O)(=O)CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | |||
| 59554895 | 111952 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 664 | 7 | 1 | 6 | 5.4 | CN1CCN(c2c(F)cccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114490 | 111952 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 664 | 7 | 1 | 6 | 5.4 | CN1CCN(c2c(F)cccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 44593545 | 185233 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 474 | 3 | 3 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL466192 | 185233 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 474 | 3 | 3 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2 | 10.1016/j.bmcl.2008.10.106 | |||
| 25227362 | 180512 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 460 | 3 | 3 | 7 | 0.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n4c5c(cccc53)NC(=O)C4)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL453643 | 180512 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 460 | 3 | 3 | 7 | 0.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n4c5c(cccc53)NC(=O)C4)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| 25227362 | 180512 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 460 | 3 | 3 | 7 | 0.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n4c5c(cccc53)NC(=O)C4)cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL453643 | 180512 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 460 | 3 | 3 | 7 | 0.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n4c5c(cccc53)NC(=O)C4)cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| 46885243 | 15100 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 467 | 2 | 2 | 5 | 2.9 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(CN4CC5(C)CC(=O)Nc6cccc4c65)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1092838 | 15100 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 467 | 2 | 2 | 5 | 2.9 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(CN4CC5(C)CC(=O)Nc6cccc4c65)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| 11977643 | 187425 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 585 | 4 | 2 | 4 | 4.9 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(c2cc3ccccc3[nH]c2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4754995 | 187425 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 585 | 4 | 2 | 4 | 4.9 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(c2cc3ccccc3[nH]c2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| 24863323 | 83273 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 613 | 6 | 3 | 6 | 3.6 | O=C(N[C@H](Cc1ccc2[nH]nnc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059878 | 83273 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 613 | 6 | 3 | 6 | 3.6 | O=C(N[C@H](Cc1ccc2[nH]nnc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| 70694802 | 83275 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 614 | 6 | 2 | 6 | 5.0 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059880 | 83275 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 614 | 6 | 2 | 6 | 5.0 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| 45485640 | 204169 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 498 | 5 | 2 | 4 | 3.0 | CN1C(=O)NC(=O)[C@@]12Cc1ccc(NC(=O)CN(Cc3cc(F)cc(F)c3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| CHEMBL569340 | 204169 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 498 | 5 | 2 | 4 | 3.0 | CN1C(=O)NC(=O)[C@@]12Cc1ccc(NC(=O)CN(Cc3cc(F)cc(F)c3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| 46885242 | 15099 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 473 | 2 | 2 | 5 | 4.1 | O=C1CC2CN(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)Nc4ncccc43)c3cccc(c32)N1 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1092837 | 15099 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 473 | 2 | 2 | 5 | 4.1 | O=C1CC2CN(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)Nc4ncccc43)c3cccc(c32)N1 | 10.1016/j.bmcl.2010.02.086 | |||
| 25034109 | 185273 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 628 | 6 | 2 | 5 | 5.5 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1021/jm800546t | |||
| CHEMBL466555 | 185273 | 0 | None | - | 1 | Human | 9.3 | pKi | = | 9.3 | Binding | ChEMBL | 628 | 6 | 2 | 5 | 5.5 | O=C(N[C@H](Cc1csc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1021/jm800546t | |||
| 54587752 | 68277 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 574 | 3 | 2 | 5 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)cnc21)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770716 | 68277 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 574 | 3 | 2 | 5 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CC(F)(F)F)cnc21)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| 44570579 | 197610 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 503 | 4 | 2 | 8 | 2.6 | O=C(Cn1c(=O)n(-c2ccncn2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL518422 | 197610 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 503 | 4 | 2 | 8 | 2.6 | O=C(Cn1c(=O)n(-c2ccncn2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | |||
| 54581897 | 68279 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 536 | 4 | 2 | 6 | 4.0 | COCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770718 | 68279 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 536 | 4 | 2 | 6 | 4.0 | COCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| 11520007 | 68278 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 600 | 3 | 2 | 5 | 5.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(C3(C(F)(F)F)CC3)cnc21)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770717 | 68278 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 600 | 3 | 2 | 5 | 5.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(C3(C(F)(F)F)CC3)cnc21)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2010.12.054 | |||
| 70690615 | 83234 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 730 | 6 | 3 | 6 | 5.0 | O=C(N[C@H](Cc1cc(Br)c(O)c(Br)c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059794 | 83234 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 730 | 6 | 3 | 6 | 5.0 | O=C(N[C@H](Cc1cc(Br)c(O)c(Br)c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| 24863334 | 83272 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 627 | 6 | 3 | 5 | 3.8 | O=C1Cc2cc(C[C@@H](NC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N3CCC(N4CCCCC4)CC3)ccc2N1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059877 | 83272 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 627 | 6 | 3 | 5 | 3.8 | O=C1Cc2cc(C[C@@H](NC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N3CCC(N4CCCCC4)CC3)ccc2N1 | 10.1016/j.bmcl.2012.05.074 | |||
| 51357855 | 89334 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 535 | 3 | 2 | 7 | 4.5 | O=C(O[C@@H]1CC[C@H](c2cccc(F)c2F)[C@H](O)c2cccnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm3013147 | |||
| CHEMBL2178421 | 89334 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 535 | 3 | 2 | 7 | 4.5 | O=C(O[C@@H]1CC[C@H](c2cccc(F)c2F)[C@H](O)c2cccnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm3013147 | |||
| 11606400 | 68269 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 549 | 4 | 2 | 6 | 5.0 | CC(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770568 | 68269 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 549 | 4 | 2 | 6 | 5.0 | CC(C)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| 52943413 | 25010 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 526 | 4 | 1 | 4 | 5.5 | CC(C)(C)C(=O)N(Cc1cc(F)cc(F)c1)Cc1cnc2cc3c(cc2c1)C[C@@]1(C3)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2010.08.105 | |||
| CHEMBL1270197 | 25010 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 526 | 4 | 1 | 4 | 5.5 | CC(C)(C)C(=O)N(Cc1cc(F)cc(F)c1)Cc1cnc2cc3c(cc2c1)C[C@@]1(C3)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2010.08.105 | |||
| 11432931 | 168691 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 558 | 6 | 2 | 6 | 3.5 | CSCCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | |||
| CHEMBL415263 | 168691 | 0 | None | - | 1 | Human | 9.2 | pKi | = | 9.2 | Binding | ChEMBL | 558 | 6 | 2 | 6 | 3.5 | CSCCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | |||
| 11979133 | 186233 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 573 | 4 | 2 | 4 | 5.4 | CC(C)(C)CN1Cc2c(cc(Cl)c3[nH]ncc23)C[C@@H](CC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4740622 | 186233 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 573 | 4 | 2 | 4 | 5.4 | CC(C)(C)CN1Cc2c(cc(Cl)c3[nH]ncc23)C[C@@H](CC(=O)N2CCC(c3cc4ccccc4[nH]c3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2013.04.012 | |||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2013.04.012 | |||
| 46178995 | 131960 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 564 | 3 | 1 | 4 | 6.3 | O=C1N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)[C@H](c2cc(F)cc(F)c2)CCC12CCCC2 | nan | |||
| CHEMBL3645140 | 131960 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 564 | 3 | 1 | 4 | 6.3 | O=C1N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)[C@H](c2cc(F)cc(F)c2)CCC12CCCC2 | nan | |||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1021/jm500364u | |||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1021/jm500364u | |||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1021/ml400199p | |||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1021/ml400199p | |||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1021/jm070668p | |||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2009.09.066 | |||
| 11319053 | 95928 | 51 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2009.06.057 | |||
| CHEMBL236593 | 95928 | 51 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 566 | 4 | 2 | 6 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncccc32)CC1 | 10.1016/j.bmcl.2009.06.057 | |||
| 45485677 | 205613 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 476 | 5 | 2 | 4 | 3.3 | C[C@H](c1ccccc1)N(CC(=O)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)NC(=O)N1C)C(=O)C(C)(C)C | 10.1016/j.bmcl.2009.07.134 | |||
| CHEMBL583679 | 205613 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 476 | 5 | 2 | 4 | 3.3 | C[C@H](c1ccccc1)N(CC(=O)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)NC(=O)N1C)C(=O)C(C)(C)C | 10.1016/j.bmcl.2009.07.134 | |||
| 164626466 | 193072 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 601 | 4 | 2 | 3 | 5.4 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ccc3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| CHEMBL4874351 | 193072 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 601 | 4 | 2 | 3 | 5.4 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ccc3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2021.128077 | |||
| 44570614 | 184380 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 525 | 4 | 2 | 7 | 3.9 | O=C(Cn1c(=O)n(C2CCSCC2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL464078 | 184380 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 525 | 4 | 2 | 7 | 3.9 | O=C(Cn1c(=O)n(C2CCSCC2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | |||
| 46179164 | 131965 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 579 | 3 | 2 | 5 | 5.3 | O=C1N(Cc2ccc3nc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)[C@H](c2cc(F)cc(F)c2)CCNC12CCCC2 | nan | |||
| CHEMBL3645145 | 131965 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 579 | 3 | 2 | 5 | 5.3 | O=C1N(Cc2ccc3nc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)[C@H](c2cc(F)cc(F)c2)CCNC12CCCC2 | nan | |||
| 11284233 | 96662 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 548 | 5 | 2 | 5 | 3.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL237849 | 96662 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 548 | 5 | 2 | 5 | 3.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 11387595 | 153760 | 1 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 575 | 5 | 2 | 6 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(Cc2ccccn2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL392635 | 153760 | 1 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 575 | 5 | 2 | 6 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(Cc2ccccn2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 59555048 | 111948 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2[C@@H]2S[C@H](CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114486 | 111948 | 0 | None | - | 1 | Human | 9.1 | pKi | = | 9.1 | Binding | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2[C@@H]2S[C@H](CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 11628603 | 188499 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 597 | 4 | 3 | 4 | 4.9 | O=C(N[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(Cc2ccccc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4777037 | 188499 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 597 | 4 | 3 | 4 | 4.9 | O=C(N[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(Cc2ccccc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| 54582783 | 68257 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 548 | 4 | 2 | 7 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(C3CC3)nnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770556 | 68257 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 548 | 4 | 2 | 7 | 4.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(C3CC3)nnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| 59554993 | 111951 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 632 | 7 | 2 | 6 | 4.9 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCNCC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114489 | 111951 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 632 | 7 | 2 | 6 | 4.9 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCNCC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 59555066 | 111955 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 664 | 7 | 1 | 6 | 5.4 | CN1CCN(c2cccc(F)c2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114493 | 111955 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 664 | 7 | 1 | 6 | 5.4 | CN1CCN(c2cccc(F)c2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 76332330 | 111983 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 706 | 7 | 1 | 6 | 6.6 | CC(C)(C)CCN1C(=O)[C@H](CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)S[C@H]1c1cccc(F)c1N1CCN(C(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114677 | 111983 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9 | Binding | ChEMBL | 706 | 7 | 1 | 6 | 6.6 | CC(C)(C)CCN1C(=O)[C@H](CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)S[C@H]1c1cccc(F)c1N1CCN(C(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 11541560 | 68267 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 583 | 4 | 2 | 6 | 5.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(-c3ccccc3)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770566 | 68267 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 583 | 4 | 2 | 6 | 5.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(-c3ccccc3)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| 11721278 | 68268 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 590 | 4 | 2 | 8 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(-c3nccs3)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770567 | 68268 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 590 | 4 | 2 | 8 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(-c3nccs3)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| 11512928 | 148449 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 632 | 6 | 2 | 7 | 5.4 | COc1cccc(-c2cn(C3CCN(C(=O)N[C@@H]4N=C(c5ccccc5)c5ccccc5N(CC(F)(F)F)C4=O)CC3)c(O)n2)c1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL385454 | 148449 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 632 | 6 | 2 | 7 | 5.4 | COc1cccc(-c2cn(C3CCN(C(=O)N[C@@H]4N=C(c5ccccc5)c5ccccc5N(CC(F)(F)F)C4=O)CC3)c(O)n2)c1 | 10.1016/j.bmcl.2006.07.044 | |||
| 11692628 | 204404 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 567 | 3 | 2 | 5 | 4.3 | O=C1Nc2ncccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)O1 | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL570746 | 204404 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 567 | 3 | 2 | 5 | 4.3 | O=C1Nc2ncccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)O1 | 10.1016/j.bmcl.2009.09.066 | |||
| 45271754 | 201833 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 479 | 3 | 3 | 5 | 3.3 | O=C(CN1CC2CCC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | |||
| CHEMBL549503 | 201833 | 0 | None | - | 1 | Human | 9.0 | pKi | = | 9.0 | Binding | ChEMBL | 479 | 3 | 3 | 5 | 3.3 | O=C(CN1CC2CCC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | |||
| 44570580 | 184226 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 495 | 4 | 2 | 7 | 2.8 | O=C(Cn1c(=O)n(C2CCOC2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL463880 | 184226 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 495 | 4 | 2 | 7 | 2.8 | O=C(Cn1c(=O)n(C2CCOC2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | |||
| 45485646 | 204552 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 514 | 5 | 2 | 4 | 3.5 | CN1C(=O)NC(=O)[C@@]12Cc1ccc(NC(=O)CN(Cc3cc(F)cc(Cl)c3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| CHEMBL571797 | 204552 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 514 | 5 | 2 | 4 | 3.5 | CN1C(=O)NC(=O)[C@@]12Cc1ccc(NC(=O)CN(Cc3cc(F)cc(Cl)c3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| 23582940 | 203381 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 465 | 3 | 3 | 5 | 3.0 | O=C(CN1CC2CC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | |||
| CHEMBL564088 | 203381 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 465 | 3 | 3 | 5 | 3.0 | O=C(CN1CC2CC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | |||
| 46179074 | 131961 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 547 | 3 | 1 | 5 | 5.4 | O=C1N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)C(c2ccccc2Cl)=NC12CCCC2 | nan | |||
| CHEMBL3645141 | 131961 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 547 | 3 | 1 | 5 | 5.4 | O=C1N(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)C(c2ccccc2Cl)=NC12CCCC2 | nan | |||
| 52947106 | 24992 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 490 | 4 | 1 | 4 | 5.2 | CC(C)(C)C(=O)N(Cc1ccccc1)Cc1cnc2cc3c(cc2c1)C[C@@]1(C3)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2010.08.105 | |||
| CHEMBL1270088 | 24992 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 490 | 4 | 1 | 4 | 5.2 | CC(C)(C)C(=O)N(Cc1ccccc1)Cc1cnc2cc3c(cc2c1)C[C@@]1(C3)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2010.08.105 | |||
| 46885245 | 14619 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 481 | 3 | 2 | 5 | 3.3 | CCC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@@]1(C4)C(=O)NC(=O)N1C)C2 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1089772 | 14619 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 481 | 3 | 2 | 5 | 3.3 | CCC12CC(=O)Nc3cccc(c31)N(Cc1ccc3cc4c(cc3n1)C[C@@]1(C4)C(=O)NC(=O)N1C)C2 | 10.1016/j.bmcl.2010.02.086 | |||
| 11753021 | 96485 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 538 | 5 | 2 | 5 | 3.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC2CC2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL237663 | 96485 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 538 | 5 | 2 | 5 | 3.5 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC2CC2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 11752904 | 154129 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 530 | 5 | 2 | 5 | 3.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCF)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL392937 | 154129 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 530 | 5 | 2 | 5 | 3.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCF)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 45271740 | 203325 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 477 | 3 | 2 | 5 | 3.2 | CN1C(=O)Cc2cn(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)Nc4ncccc43)c3cccc1c23 | 10.1016/j.bmcl.2009.06.057 | |||
| CHEMBL563727 | 203325 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 477 | 3 | 2 | 5 | 3.2 | CN1C(=O)Cc2cn(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)Nc4ncccc43)c3cccc1c23 | 10.1016/j.bmcl.2009.06.057 | |||
| 46885134 | 14807 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 446 | 2 | 1 | 4 | 4.1 | O=C1CCc2ccccc2N1Cc1ccc2cc3c(cc2n1)C[C@@]1(C3)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1090847 | 14807 | 0 | None | - | 1 | Human | 8.9 | pKi | = | 8.9 | Binding | ChEMBL | 446 | 2 | 1 | 4 | 4.1 | O=C1CCc2ccccc2N1Cc1ccc2cc3c(cc2n1)C[C@@]1(C3)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2010.02.086 | |||
| 11979010 | 190229 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 577 | 3 | 3 | 4 | 4.7 | CC(C)(C)CN1Cc2c(cc(Cl)c3[nH]ncc23)C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4798946 | 190229 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 577 | 3 | 3 | 4 | 4.7 | CC(C)(C)CN1Cc2c(cc(Cl)c3[nH]ncc23)C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| 46885186 | 14805 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 453 | 2 | 2 | 5 | 2.7 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(CN4CC5CC(=O)Nc6cccc4c65)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1090841 | 14805 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 453 | 2 | 2 | 5 | 2.7 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(CN4CC5CC(=O)Nc6cccc4c65)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| 45485645 | 204522 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 480 | 5 | 2 | 4 | 2.9 | CN1C(=O)NC(=O)C12Cc1ccc(NC(=O)CN(Cc3cccc(F)c3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| CHEMBL571580 | 204522 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 480 | 5 | 2 | 4 | 2.9 | CN1C(=O)NC(=O)C12Cc1ccc(NC(=O)CN(Cc3cccc(F)c3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| 45254467 | 133761 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 597 | 5 | 3 | 5 | 4.0 | C[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1ccc2c(c1)CC1(C2)N=C(c2ccccc2)NC1=O | nan | |||
| CHEMBL3655572 | 133761 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 597 | 5 | 3 | 5 | 4.0 | C[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1ccc2c(c1)CC1(C2)N=C(c2ccccc2)NC1=O | nan | |||
| 11180666 | 153872 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 574 | 6 | 2 | 6 | 2.5 | C[S+]([O-])CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | |||
| CHEMBL392730 | 153872 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 574 | 6 | 2 | 6 | 2.5 | C[S+]([O-])CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | |||
| 44570615 | 184381 | 9 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 494 | 3 | 2 | 5 | 3.1 | O=C(CN1C(=O)C2(CCOCC2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL464079 | 184381 | 9 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 494 | 3 | 2 | 5 | 3.1 | O=C(CN1C(=O)C2(CCOCC2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | |||
| 44593445 | 198308 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 518 | 5 | 2 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL519421 | 198308 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 518 | 5 | 2 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.106 | |||
| 44593445 | 198308 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 518 | 5 | 2 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL519421 | 198308 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 518 | 5 | 2 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)N(C)C | 10.1016/j.bmcl.2008.10.019 | |||
| 11584808 | 204467 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 551 | 3 | 2 | 4 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL571203 | 204467 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 551 | 3 | 2 | 4 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)C(=O)Nc1ncccc12 | 10.1016/j.bmcl.2009.09.066 | |||
| 45485664 | 204117 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 496 | 5 | 2 | 4 | 3.4 | CN1C(=O)NC(=O)C12Cc1ccc(NC(=O)CN(Cc3cccc(Cl)c3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| CHEMBL568920 | 204117 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 496 | 5 | 2 | 4 | 3.4 | CN1C(=O)NC(=O)C12Cc1ccc(NC(=O)CN(Cc3cccc(Cl)c3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| 45485625 | 204558 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 462 | 5 | 2 | 4 | 2.7 | CN1C(=O)NC(=O)[C@@]12Cc1ccc(NC(=O)CN(Cc3ccccc3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2010.08.105 | |||
| CHEMBL571823 | 204558 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 462 | 5 | 2 | 4 | 2.7 | CN1C(=O)NC(=O)[C@@]12Cc1ccc(NC(=O)CN(Cc3ccccc3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2010.08.105 | |||
| 45485625 | 204558 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 462 | 5 | 2 | 4 | 2.7 | CN1C(=O)NC(=O)[C@@]12Cc1ccc(NC(=O)CN(Cc3ccccc3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| CHEMBL571823 | 204558 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 462 | 5 | 2 | 4 | 2.7 | CN1C(=O)NC(=O)[C@@]12Cc1ccc(NC(=O)CN(Cc3ccccc3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| 44563052 | 192814 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 490 | 5 | 3 | 7 | 0.6 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(N)=O | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL487068 | 192814 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 490 | 5 | 3 | 7 | 0.6 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(N)=O | 10.1016/j.bmcl.2008.10.019 | |||
| 25019940 | 74724 | 33 | None | -478 | 2 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 557 | 4 | 3 | 5 | 3.8 | O=C(CN1C(=O)C2(CCCC2)NC[C@H]1c1cc(F)cc(F)c1)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1021/jm500364u | |||
| CHEMBL1910936 | 74724 | 33 | None | -478 | 2 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 557 | 4 | 3 | 5 | 3.8 | O=C(CN1C(=O)C2(CCCC2)NC[C@H]1c1cc(F)cc(F)c1)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1021/jm500364u | |||
| 59555258 | 111947 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2[C@H]2S[C@H](CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114485 | 111947 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2[C@H]2S[C@H](CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 25019940 | 74724 | 33 | None | -478 | 2 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 557 | 4 | 3 | 5 | 3.8 | O=C(CN1C(=O)C2(CCCC2)NC[C@H]1c1cc(F)cc(F)c1)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | |||
| CHEMBL1910936 | 74724 | 33 | None | -478 | 2 | Rat | 8.0 | pKi | = | 8 | Binding | ChEMBL | 557 | 4 | 3 | 5 | 3.8 | O=C(CN1C(=O)C2(CCCC2)NC[C@H]1c1cc(F)cc(F)c1)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | |||
| 44420250 | 143706 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 551 | 4 | 2 | 8 | 2.3 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4nccc(C(F)(F)F)n4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL374251 | 143706 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 551 | 4 | 2 | 8 | 2.3 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4nccc(C(F)(F)F)n4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| 11432505 | 204412 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 527 | 4 | 2 | 4 | 3.3 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(c2ccn[nH]c2=O)CC1 | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL570793 | 204412 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8 | Binding | ChEMBL | 527 | 4 | 2 | 4 | 3.3 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(c2ccn[nH]c2=O)CC1 | 10.1016/j.bmcl.2009.09.066 | |||
| 44562938 | 185873 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 419 | 3 | 3 | 5 | 1.3 | Cc1ccc2c(c1)[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL471705 | 185873 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 419 | 3 | 3 | 5 | 1.3 | Cc1ccc2c(c1)[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | |||
| 45487023 | 205598 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 526 | 4 | 2 | 3 | 3.9 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(c2ccc[nH]c2=O)CC1 | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL583547 | 205598 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 526 | 4 | 2 | 3 | 3.9 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(c2ccc[nH]c2=O)CC1 | 10.1016/j.bmcl.2009.09.066 | |||
| 44416442 | 87352 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 593 | 4 | 2 | 7 | 3.5 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3c2ccc[n+]3[O-])CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL214950 | 87352 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 593 | 4 | 2 | 7 | 3.5 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3c2ccc[n+]3[O-])CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 44420286 | 91030 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 406 | 3 | 2 | 6 | 1.3 | CN1C(=O)NC(=O)C12Cc1ccc(NC(=O)Cn3c(=O)oc4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL221160 | 91030 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 406 | 3 | 2 | 6 | 1.3 | CN1C(=O)NC(=O)C12Cc1ccc(NC(=O)Cn3c(=O)oc4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| 44417049 | 175598 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 686 | 6 | 2 | 7 | 6.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccc(OC(F)(F)F)cc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL437718 | 175598 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 686 | 6 | 2 | 7 | 6.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccc(OC(F)(F)F)cc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 11848968 | 101980 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 518 | 4 | 2 | 7 | 4.0 | O=C(Nc1cc(-c2ccsc2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL255967 | 101980 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 518 | 4 | 2 | 7 | 4.0 | O=C(Nc1cc(-c2ccsc2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| 11570753 | 176346 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 605 | 5 | 2 | 5 | 4.1 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2CC(c3cccnc3)NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL443577 | 176346 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 605 | 5 | 2 | 5 | 4.1 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2CC(c3cccnc3)NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 44420290 | 91402 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 406 | 3 | 2 | 6 | 1.3 | CN1C(=O)NC(=O)[C@@]12Cc1ccc(NC(=O)Cn3c(=O)oc4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL222198 | 91402 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 406 | 3 | 2 | 6 | 1.3 | CN1C(=O)NC(=O)[C@@]12Cc1ccc(NC(=O)Cn3c(=O)oc4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| 44416513 | 148660 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 619 | 5 | 3 | 7 | 4.0 | NC(=O)c1ccc2c(c1)nc(O)n2C1CCN(C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(F)(F)F)C2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL386714 | 148660 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 619 | 5 | 3 | 7 | 4.0 | NC(=O)c1ccc2c(c1)nc(O)n2C1CCN(C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(F)(F)F)C2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 71569532 | 94441 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 654 | 6 | 3 | 7 | 3.6 | N#Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2oc(=O)[nH]c12 | 10.1016/j.bmcl.2013.01.011 | |||
| CHEMBL2336414 | 94441 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 654 | 6 | 3 | 7 | 3.6 | N#Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2oc(=O)[nH]c12 | 10.1016/j.bmcl.2013.01.011 | |||
| 11168000 | 160962 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 502 | 5 | 2 | 5 | 3.3 | O=C(N[C@@H]1CC[C@@H](c2ccccc2)CN(CC2CC2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL398575 | 160962 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 502 | 5 | 2 | 5 | 3.3 | O=C(N[C@@H]1CC[C@@H](c2ccccc2)CN(CC2CC2)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 11628731 | 87168 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 620 | 5 | 2 | 6 | 5.5 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3cccc(F)c3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL214507 | 87168 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 620 | 5 | 2 | 6 | 5.5 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3cccc(F)c3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 44416912 | 87632 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 620 | 5 | 2 | 6 | 5.5 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccc(F)cc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL215274 | 87632 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 620 | 5 | 2 | 6 | 5.5 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccc(F)cc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 11707040 | 87853 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 602 | 5 | 2 | 6 | 5.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccccc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL215499 | 87853 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 602 | 5 | 2 | 6 | 5.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccccc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 11519899 | 148265 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 584 | 5 | 2 | 8 | 3.5 | COC(=O)c1cn(C2CCN(C(=O)N[C@@H]3N=C(c4ccccc4)c4ccccc4N(CC(F)(F)F)C3=O)CC2)c(O)n1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL384408 | 148265 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 584 | 5 | 2 | 8 | 3.5 | COC(=O)c1cn(C2CCN(C(=O)N[C@@H]3N=C(c4ccccc4)c4ccccc4N(CC(F)(F)F)C3=O)CC2)c(O)n1 | 10.1016/j.bmcl.2006.07.044 | |||
| 23656751 | 98516 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 462 | 3 | 3 | 5 | 2.4 | Cc1ccc(C2CC[C@@H](NC(=O)N3CCC(n4c(=O)[nH]c5ncccc54)CC3)C(=O)NC2)cc1 | 10.1021/jm070668p | |||
| CHEMBL240903 | 98516 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 462 | 3 | 3 | 5 | 2.4 | Cc1ccc(C2CC[C@@H](NC(=O)N3CCC(n4c(=O)[nH]c5ncccc54)CC3)C(=O)NC2)cc1 | 10.1021/jm070668p | |||
| 11549001 | 148657 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 616 | 6 | 2 | 6 | 5.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(Cc3ccccc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL386701 | 148657 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 616 | 6 | 2 | 6 | 5.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(Cc3ccccc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 59554867 | 111987 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 492 | 5 | 1 | 4 | 4.5 | CC(C)N1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114681 | 111987 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 492 | 5 | 1 | 4 | 4.5 | CC(C)N1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| 59555008 | 111933 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 570 | 6 | 1 | 4 | 5.8 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1cccc(F)c1F | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114471 | 111933 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 570 | 6 | 1 | 4 | 5.8 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1cccc(F)c1F | 10.1016/j.bmcl.2013.12.089 | |||
| 11978769 | 189153 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 563 | 4 | 3 | 4 | 4.2 | O=C(N[C@@H]1Cc2ccc3[nH]ncc3c2CN(Cc2ccccc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4785088 | 189153 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 563 | 4 | 3 | 4 | 4.2 | O=C(N[C@@H]1Cc2ccc3[nH]ncc3c2CN(Cc2ccccc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| 52945887 | 24991 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 470 | 4 | 1 | 4 | 3.8 | CN1C(=O)NC(=O)[C@]12Cc1cc3cc(CN(Cc4ccccc4)C(=O)C(C)(C)C)cnc3cc1C2 | 10.1016/j.bmcl.2010.08.105 | |||
| CHEMBL1270087 | 24991 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 470 | 4 | 1 | 4 | 3.8 | CN1C(=O)NC(=O)[C@]12Cc1cc3cc(CN(Cc4ccccc4)C(=O)C(C)(C)C)cnc3cc1C2 | 10.1016/j.bmcl.2010.08.105 | |||
| 44420256 | 91722 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 483 | 4 | 2 | 8 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4cnccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL223756 | 91722 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 483 | 4 | 2 | 8 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4cnccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| 44563026 | 193422 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 435 | 4 | 3 | 6 | 1.0 | COc1ccc2[nH]c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c2c1 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL488065 | 193422 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 435 | 4 | 3 | 6 | 1.0 | COc1ccc2[nH]c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c2c1 | 10.1016/j.bmcl.2008.10.019 | |||
| 59555056 | 111922 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 3.7 | COCCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114460 | 111922 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 508 | 7 | 1 | 5 | 3.7 | COCCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| 11713849 | 205668 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 564 | 3 | 2 | 3 | 4.6 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)Cc1ccccc1NC2=O | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL584311 | 205668 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 564 | 3 | 2 | 3 | 4.6 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)Cc1ccccc1NC2=O | 10.1016/j.bmcl.2009.09.066 | |||
| 70685988 | 81865 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 606 | 4 | 3 | 6 | 4.0 | C[C@@]1(c2cc(F)c(Cl)c(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | |||
| CHEMBL2035985 | 81865 | 0 | None | - | 1 | Rat | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 606 | 4 | 3 | 6 | 4.0 | C[C@@]1(c2cc(F)c(Cl)c(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | |||
| 44570499 | 199175 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 505 | 4 | 2 | 7 | 2.5 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCSCC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL520778 | 199175 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 505 | 4 | 2 | 7 | 2.5 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCSCC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | |||
| 44562897 | 185845 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4c(Cl)cccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL471530 | 185845 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4c(Cl)cccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| 44563126 | 195712 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 490 | 7 | 3 | 7 | 0.7 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(CCCC(N)=O)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL508016 | 195712 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 490 | 7 | 3 | 7 | 0.7 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(CCCC(N)=O)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| 44570461 | 186025 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 529 | 5 | 2 | 8 | 2.6 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)C[C@@]1(C2)N=C(c2cccnc2)NC1=O | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL472829 | 186025 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 529 | 5 | 2 | 8 | 2.6 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)C[C@@]1(C2)N=C(c2cccnc2)NC1=O | 10.1016/j.bmcl.2008.10.106 | |||
| 45254662 | 133758 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 529 | 5 | 2 | 8 | 2.6 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)N=C(c2cccnc2)NC1=O | nan | |||
| CHEMBL3655569 | 133758 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 529 | 5 | 2 | 8 | 2.6 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)N=C(c2cccnc2)NC1=O | nan | |||
| 25119464 | 189323 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 529 | 4 | 3 | 4 | 3.7 | CC(C)CN1Cc2c(ccc3[nH]ncc23)C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4787479 | 189323 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 529 | 4 | 3 | 4 | 3.7 | CC(C)CN1Cc2c(ccc3[nH]ncc23)C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| 59555055 | 111953 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 664 | 7 | 1 | 6 | 5.4 | CN1CCN(c2cc(F)ccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114491 | 111953 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 664 | 7 | 1 | 6 | 5.4 | CN1CCN(c2cc(F)ccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 59554934 | 111954 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 664 | 7 | 1 | 6 | 5.4 | CN1CCN(c2ccc(F)cc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114492 | 111954 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 664 | 7 | 1 | 6 | 5.4 | CN1CCN(c2ccc(F)cc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 45485631 | 204492 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 480 | 5 | 2 | 4 | 2.9 | CN1C(=O)NC(=O)C12Cc1ccc(NC(=O)CN(Cc3ccccc3F)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| CHEMBL571350 | 204492 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 480 | 5 | 2 | 4 | 2.9 | CN1C(=O)NC(=O)C12Cc1ccc(NC(=O)CN(Cc3ccccc3F)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| 44455457 | 101985 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 478 | 6 | 3 | 8 | 1.8 | COCCn1cc(-c2ccn[nH]2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL255998 | 101985 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 478 | 6 | 3 | 8 | 1.8 | COCCn1cc(-c2ccn[nH]2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 45487059 | 204466 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 502 | 3 | 2 | 3 | 2.9 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CCNC2=O)CC1 | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL571185 | 204466 | 0 | None | - | 1 | Human | 6.9 | pKi | = | 6.9 | Binding | ChEMBL | 502 | 3 | 2 | 3 | 2.9 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CCNC2=O)CC1 | 10.1016/j.bmcl.2009.09.066 | |||
| 70690614 | 83233 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 588 | 7 | 2 | 6 | 3.8 | COc1ccc(C[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059793 | 83233 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 588 | 7 | 2 | 6 | 3.8 | COc1ccc(C[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc1 | 10.1016/j.bmcl.2012.05.074 | |||
| 44416437 | 148572 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 610 | 4 | 2 | 6 | 5.5 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3c(Cl)cccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL386204 | 148572 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 610 | 4 | 2 | 6 | 5.5 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3c(Cl)cccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 44420245 | 90779 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 512 | 5 | 2 | 8 | 1.9 | COc1cccc(-n2c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c3ccccc32)n1 | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL220715 | 90779 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 512 | 5 | 2 | 8 | 1.9 | COc1cccc(-n2c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c3ccccc32)n1 | 10.1016/j.bmcl.2006.09.045 | |||
| 44562939 | 185874 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4cc(Cl)ccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL471706 | 185874 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4cc(Cl)ccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| 44563025 | 199274 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 423 | 3 | 3 | 5 | 1.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccc(F)cc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL520905 | 199274 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 423 | 3 | 3 | 5 | 1.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccc(F)cc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| 44455043 | 102501 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 462 | 3 | 2 | 6 | 3.1 | Cn1cc(-c2cccc(F)c2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL258329 | 102501 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 462 | 3 | 2 | 6 | 3.1 | Cn1cc(-c2cccc(F)c2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 11444589 | 86564 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 578 | 4 | 2 | 8 | 3.7 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3nccnc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL211931 | 86564 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 578 | 4 | 2 | 8 | 3.7 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3nccnc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 70690616 | 83242 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 611 | 6 | 2 | 6 | 4.3 | Cn1cc(C[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)C(=O)N2CCC(N3CCCCC3)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059802 | 83242 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 611 | 6 | 2 | 6 | 4.3 | Cn1cc(C[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)C(=O)N2CCC(N3CCCCC3)CC2)c2ccccc21 | 10.1016/j.bmcl.2012.05.074 | |||
| 44570498 | 190819 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 483 | 4 | 2 | 8 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccncn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL482178 | 190819 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 483 | 4 | 2 | 8 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccncn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | |||
| 45254661 | 133759 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 529 | 5 | 2 | 8 | 2.6 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)N=C(c2ccncc2)NC1=O | nan | |||
| CHEMBL3655570 | 133759 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 529 | 5 | 2 | 8 | 2.6 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)N=C(c2ccncc2)NC1=O | nan | |||
| 44455041 | 177376 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 480 | 3 | 2 | 6 | 3.2 | Cn1cc(-c2cccc(F)c2F)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL445069 | 177376 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 480 | 3 | 2 | 6 | 3.2 | Cn1cc(-c2cccc(F)c2F)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 56944164 | 81863 | 3 | None | -194 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 572 | 4 | 3 | 6 | 3.3 | C[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | |||
| CHEMBL2035983 | 81863 | 3 | None | -194 | 4 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 572 | 4 | 3 | 6 | 3.3 | C[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | |||
| 11849025 | 102260 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 548 | 4 | 2 | 6 | 4.3 | O=C(Nc1cc(-c2cccc(F)c2F)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL257252 | 102260 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 548 | 4 | 2 | 6 | 4.3 | O=C(Nc1cc(-c2cccc(F)c2F)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| 44420261 | 144061 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 523 | 4 | 2 | 8 | 0.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCS(=O)(=O)C4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL375224 | 144061 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 523 | 4 | 2 | 8 | 0.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCS(=O)(=O)C4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| 46885132 | 14943 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 490 | 3 | 1 | 7 | 2.8 | CN1C(=O)NC(=O)[C@]12Cc1cc3ccc(Cn4c(=O)n(-c5ccccn5)c5ccccc54)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1091903 | 14943 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 490 | 3 | 1 | 7 | 2.8 | CN1C(=O)NC(=O)[C@]12Cc1cc3ccc(Cn4c(=O)n(-c5ccccn5)c5ccccc54)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| 11977970 | 187811 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 544 | 5 | 3 | 5 | 2.6 | CN(C)CCN1Cc2c(ccc3[nH]ncc23)C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4759318 | 187811 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 544 | 5 | 3 | 5 | 2.6 | CN(C)CCN1Cc2c(ccc3[nH]ncc23)C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| 11848963 | 162213 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 484 | 5 | 2 | 6 | 3.8 | O=C(Nc1cc(-c2ccccc2)cn(CC2CC2)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL403765 | 162213 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 484 | 5 | 2 | 6 | 3.8 | O=C(Nc1cc(-c2ccccc2)cn(CC2CC2)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| 23656750 | 98505 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 478 | 4 | 3 | 6 | 2.1 | COc1ccccc1C1CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C(=O)NC1 | 10.1021/jm070668p | |||
| CHEMBL240902 | 98505 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 478 | 4 | 3 | 6 | 2.1 | COc1ccccc1C1CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C(=O)NC1 | 10.1021/jm070668p | |||
| 11848753 | 165677 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 522 | 4 | 2 | 8 | 2.4 | Cn1cc(-c2ccc(S(C)(=O)=O)cc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL409535 | 165677 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 522 | 4 | 2 | 8 | 2.4 | Cn1cc(-c2ccc(S(C)(=O)=O)cc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 59554936 | 111939 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 633 | 7 | 2 | 6 | 5.5 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCC(O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114477 | 111939 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 633 | 7 | 2 | 6 | 5.5 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCC(O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 70685987 | 81864 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 592 | 4 | 3 | 6 | 3.8 | O=C(CN1C(=O)C2(CCCC2)NC[C@H]1c1cc(F)c(Cl)c(F)c1)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | |||
| CHEMBL2035984 | 81864 | 0 | None | - | 1 | Rat | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 592 | 4 | 3 | 6 | 3.8 | O=C(CN1C(=O)C2(CCCC2)NC[C@H]1c1cc(F)c(Cl)c(F)c1)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | |||
| 44562982 | 192820 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 423 | 3 | 3 | 5 | 1.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4cc(F)ccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL487076 | 192820 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 423 | 3 | 3 | 5 | 1.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4cc(F)ccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| 59554947 | 111949 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2[C@@H]2S[C@@H](CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114487 | 111949 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2[C@@H]2S[C@@H](CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 16745090 | 14539 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 491 | 3 | 1 | 8 | 2.2 | CN1C(=O)NC(=O)C12Cc1cc3ncc(Cn4c(=O)n(-c5ccccn5)c5ccccc54)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1089207 | 14539 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 491 | 3 | 1 | 8 | 2.2 | CN1C(=O)NC(=O)C12Cc1cc3ncc(Cn4c(=O)n(-c5ccccn5)c5ccccc54)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| 59554857 | 111920 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 506 | 4 | 1 | 4 | 4.9 | CC(C)(C)N1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114458 | 111920 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 506 | 4 | 1 | 4 | 4.9 | CC(C)(C)N1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| 11571094 | 148668 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 668 | 7 | 2 | 7 | 6.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccc(OC(F)F)cc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL386757 | 148668 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 668 | 7 | 2 | 7 | 6.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccc(OC(F)F)cc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 56944164 | 81863 | 3 | None | -218 | 4 | Mouse | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 572 | 4 | 3 | 6 | 3.3 | C[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | |||
| CHEMBL2035983 | 81863 | 3 | None | -218 | 4 | Mouse | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 572 | 4 | 3 | 6 | 3.3 | C[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | |||
| 70686451 | 83236 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 615 | 7 | 3 | 6 | 3.7 | CC(=O)Nc1ccc(C[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059797 | 83236 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 615 | 7 | 3 | 6 | 3.7 | CC(=O)Nc1ccc(C[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc1 | 10.1016/j.bmcl.2012.05.074 | |||
| 11848798 | 102444 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 446 | 3 | 2 | 8 | 1.7 | Cn1cc(-c2ncccn2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL258069 | 102444 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 446 | 3 | 2 | 8 | 1.7 | Cn1cc(-c2ncccn2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 59555157 | 111936 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 618 | 7 | 2 | 6 | 4.9 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCNCC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114474 | 111936 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 618 | 7 | 2 | 6 | 4.9 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCNCC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 24853164 | 111938 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2C2SC(CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114476 | 111938 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2C2SC(CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 59555074 | 111946 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2[C@H]2S[C@@H](CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114484 | 111946 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 632 | 7 | 1 | 6 | 5.2 | CN1CCN(c2ccccc2[C@H]2S[C@@H](CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 59555331 | 111950 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 646 | 7 | 1 | 6 | 5.3 | CN1CCN(c2ccccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114488 | 111950 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 646 | 7 | 1 | 6 | 5.3 | CN1CCN(c2ccccc2C2SC(CC(=O)N3CCC(N4CCc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 44563050 | 193426 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 505 | 5 | 2 | 8 | 1.3 | COC(=O)Cn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2cc(C)cc(C)c21 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL488082 | 193426 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 505 | 5 | 2 | 8 | 1.3 | COC(=O)Cn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2cc(C)cc(C)c21 | 10.1016/j.bmcl.2008.10.019 | |||
| 52949562 | 24971 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 470 | 4 | 1 | 4 | 3.8 | CN1C(=O)NC(=O)C12Cc1cc3ccc(CN(Cc4ccccc4)C(=O)C(C)(C)C)nc3cc1C2 | 10.1016/j.bmcl.2010.08.105 | |||
| CHEMBL1269977 | 24971 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 470 | 4 | 1 | 4 | 3.8 | CN1C(=O)NC(=O)C12Cc1cc3ccc(CN(Cc4ccccc4)C(=O)C(C)(C)C)nc3cc1C2 | 10.1016/j.bmcl.2010.08.105 | |||
| 54581838 | 68263 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 521 | 3 | 2 | 6 | 4.2 | Cc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770562 | 68263 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 521 | 3 | 2 | 6 | 4.2 | Cc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| 44563200 | 181269 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 502 | 3 | 2 | 7 | 1.2 | CN1C(=O)CCCn2c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c3cccc1c32 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL455458 | 181269 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 502 | 3 | 2 | 7 | 1.2 | CN1C(=O)CCCn2c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c3cccc1c32 | 10.1016/j.bmcl.2008.10.019 | |||
| 45269221 | 203436 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 493 | 3 | 3 | 5 | 3.7 | O=C(CN1CC2CCCC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | |||
| CHEMBL564466 | 203436 | 0 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 493 | 3 | 3 | 5 | 3.7 | O=C(CN1CC2CCCC(=O)Nc3cccc1c32)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2009.06.057 | |||
| 44570578 | 185189 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 502 | 4 | 2 | 7 | 3.2 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL465934 | 185189 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 502 | 4 | 2 | 7 | 3.2 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)C[C@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | |||
| 11375693 | 96661 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 512 | 4 | 2 | 5 | 3.1 | CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | |||
| CHEMBL237848 | 96661 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 512 | 4 | 2 | 5 | 3.1 | CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | |||
| 54583774 | 68264 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 537 | 4 | 3 | 7 | 3.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CO)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770563 | 68264 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 537 | 4 | 3 | 7 | 3.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2c(CO)cnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| 70688552 | 83231 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 574 | 6 | 3 | 6 | 3.5 | O=C(N[C@H](Cc1ccc(O)cc1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059790 | 83231 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 574 | 6 | 3 | 6 | 3.5 | O=C(N[C@H](Cc1ccc(O)cc1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| 11225752 | 96486 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 498 | 3 | 2 | 5 | 2.8 | CN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | |||
| CHEMBL237664 | 96486 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 498 | 3 | 2 | 5 | 2.8 | CN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | |||
| 44563028 | 201345 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 447 | 3 | 2 | 6 | 1.6 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2C | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL530116 | 201345 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 447 | 3 | 2 | 6 | 1.6 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2C | 10.1016/j.bmcl.2008.10.019 | |||
| 54583775 | 68266 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 578 | 4 | 2 | 7 | 3.6 | CN(C)C(=O)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770565 | 68266 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 578 | 4 | 2 | 7 | 3.6 | CN(C)C(=O)c1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| 59555100 | 111943 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 611 | 7 | 1 | 5 | 6.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1-c1ccncc1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114481 | 111943 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 611 | 7 | 1 | 5 | 6.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1-c1ccncc1 | 10.1016/j.bmcl.2013.12.089 | |||
| 44420240 | 90250 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 475 | 4 | 2 | 7 | 1.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCOC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL220101 | 90250 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 475 | 4 | 2 | 7 | 1.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCOC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | |||
| 44420235 | 91549 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL223156 | 91549 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | |||
| 44420240 | 90250 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 475 | 4 | 2 | 7 | 1.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCOC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL220101 | 90250 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 475 | 4 | 2 | 7 | 1.4 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(C4CCOC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| 44420235 | 91549 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL223156 | 91549 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| 11505361 | 148266 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 605 | 5 | 2 | 5 | 4.1 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2CC(c3ccccn3)NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL384409 | 148266 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 605 | 5 | 2 | 5 | 4.1 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2CC(c3ccccn3)NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 11678456 | 86995 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 556 | 5 | 3 | 7 | 3.2 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(CO)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL213717 | 86995 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 556 | 5 | 3 | 7 | 3.2 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(CO)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 44416516 | 87865 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 590 | 4 | 2 | 6 | 5.2 | Cc1cccc2nc(O)n(C3CCN(C(=O)N[C@@H]4N=C(c5ccccc5)c5ccccc5N(CC(F)(F)F)C4=O)CC3)c12 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL215549 | 87865 | 0 | None | - | 1 | Human | 4.7 | pKi | = | 4.7 | Binding | ChEMBL | 590 | 4 | 2 | 6 | 5.2 | Cc1cccc2nc(O)n(C3CCN(C(=O)N[C@@H]4N=C(c5ccccc5)c5ccccc5N(CC(F)(F)F)C4=O)CC3)c12 | 10.1016/j.bmcl.2006.07.044 | |||
| 59555245 | 111931 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 555 | 7 | 1 | 5 | 4.7 | O=C(CC1SC(c2ccccc2)N(CCc2ccccn2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114469 | 111931 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 555 | 7 | 1 | 5 | 4.7 | O=C(CC1SC(c2ccccc2)N(CCc2ccccn2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 59555102 | 111986 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 464 | 4 | 1 | 4 | 3.7 | CN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114680 | 111986 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 464 | 4 | 1 | 4 | 3.7 | CN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| 11650307 | 87293 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 632 | 6 | 2 | 7 | 5.4 | COc1ccc(-c2cn(C3CCN(C(=O)N[C@@H]4N=C(c5ccccc5)c5ccccc5N(CC(F)(F)F)C4=O)CC3)c(O)n2)cc1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL214800 | 87293 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 632 | 6 | 2 | 7 | 5.4 | COc1ccc(-c2cn(C3CCN(C(=O)N[C@@H]4N=C(c5ccccc5)c5ccccc5N(CC(F)(F)F)C4=O)CC3)c(O)n2)cc1 | 10.1016/j.bmcl.2006.07.044 | |||
| 11849024 | 162062 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 502 | 4 | 3 | 7 | 2.7 | O=C(Nc1cc(-c2ccn[nH]2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL402887 | 162062 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 502 | 4 | 3 | 7 | 2.7 | O=C(Nc1cc(-c2ccn[nH]2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| 44455188 | 168021 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 434 | 3 | 2 | 8 | 1.4 | Cn1cc(C2C=NC=N2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL411896 | 168021 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 434 | 3 | 2 | 8 | 1.4 | Cn1cc(C2C=NC=N2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 44420235 | 91549 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL223156 | 91549 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| 44420235 | 91549 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL223156 | 91549 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 482 | 4 | 2 | 7 | 1.8 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| 44563051 | 193454 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 519 | 5 | 2 | 8 | 1.8 | COC(=O)[C@H](C)n1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2cc(C)cc(C)c21 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL488255 | 193454 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 519 | 5 | 2 | 8 | 1.8 | COC(=O)[C@H](C)n1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2cc(C)cc(C)c21 | 10.1016/j.bmcl.2008.10.019 | |||
| 70692757 | 83232 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 588 | 7 | 3 | 6 | 3.9 | O=C(N[C@H](CCc1ccc(O)cc1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059792 | 83232 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 588 | 7 | 3 | 6 | 3.9 | O=C(N[C@H](CCc1ccc(O)cc1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| 44455078 | 102363 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 462 | 3 | 2 | 6 | 3.1 | Cn1cc(-c2ccccc2F)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL257732 | 102363 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 462 | 3 | 2 | 6 | 3.1 | Cn1cc(-c2ccccc2F)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 162666990 | 189187 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 564 | 4 | 3 | 5 | 3.6 | O=C(N[C@@H]1Cc2ccc3[nH]ncc3c2CN(Cc2ccncc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4785645 | 189187 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 564 | 4 | 3 | 5 | 3.6 | O=C(N[C@@H]1Cc2ccc3[nH]ncc3c2CN(Cc2ccncc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| 11351794 | 97755 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NC[C@H](c2ccccc2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL239630 | 97755 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NC[C@H](c2ccccc2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 59555230 | 111942 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 611 | 7 | 1 | 5 | 6.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1-c1cccnc1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114480 | 111942 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 611 | 7 | 1 | 5 | 6.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1-c1cccnc1 | 10.1016/j.bmcl.2013.12.089 | |||
| 11421827 | 164383 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 577 | 4 | 2 | 6 | 3.8 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL408093 | 164383 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 577 | 4 | 2 | 6 | 3.8 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2008.10.106 | |||
| 44563123 | 195665 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 490 | 5 | 2 | 7 | 0.5 | CN(C)C(=O)Cn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2ccccc21 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL507339 | 195665 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 490 | 5 | 2 | 7 | 0.5 | CN(C)C(=O)Cn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2ccccc21 | 10.1016/j.bmcl.2008.10.019 | |||
| 11848645 | 104286 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 460 | 3 | 3 | 7 | 2.7 | Cn1cc(-c2ccccc2O)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL270392 | 104286 | 0 | None | - | 1 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 460 | 3 | 3 | 7 | 2.7 | Cn1cc(-c2ccccc2O)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 11365194 | 147513 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 576 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL381798 | 147513 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 576 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2008.10.106 | |||
| 11365194 | 147513 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 576 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL381798 | 147513 | 0 | None | - | 1 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 576 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 11848800 | 162051 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 488 | 6 | 2 | 7 | 3.1 | COCCn1cc(-c2ccccc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL402844 | 162051 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 488 | 6 | 2 | 7 | 3.1 | COCCn1cc(-c2ccccc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 11421827 | 164383 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 577 | 4 | 2 | 6 | 3.8 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL408093 | 164383 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 577 | 4 | 2 | 6 | 3.8 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 45485600 | 204601 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 487 | 5 | 2 | 5 | 2.6 | CN1C(=O)NC(=O)C12Cc1ccc(NC(=O)CN(Cc3cccc(C#N)c3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| CHEMBL572225 | 204601 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 487 | 5 | 2 | 5 | 2.6 | CN1C(=O)NC(=O)C12Cc1ccc(NC(=O)CN(Cc3cccc(C#N)c3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| 44562984 | 192821 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 419 | 3 | 3 | 5 | 1.3 | Cc1ccc2[nH]c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c2c1 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL487077 | 192821 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 419 | 3 | 3 | 5 | 1.3 | Cc1ccc2[nH]c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c2c1 | 10.1016/j.bmcl.2008.10.019 | |||
| 70692759 | 83238 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 608 | 6 | 2 | 5 | 4.9 | O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059799 | 83238 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 608 | 6 | 2 | 5 | 4.9 | O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| 44570375 | 185148 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 468 | 4 | 3 | 7 | 1.5 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)C[C@@]1(C2)NC(=O)NC1=O | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL465279 | 185148 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 468 | 4 | 3 | 7 | 1.5 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)C[C@@]1(C2)NC(=O)NC1=O | 10.1016/j.bmcl.2008.10.106 | |||
| 45487037 | 204378 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 603 | 5 | 2 | 4 | 4.9 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(c2cc(-c3ccccc3)n[nH]c2=O)CC1 | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL570626 | 204378 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 603 | 5 | 2 | 4 | 4.9 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(c2cc(-c3ccccc3)n[nH]c2=O)CC1 | 10.1016/j.bmcl.2009.09.066 | |||
| 70696845 | 83228 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 524 | 6 | 2 | 5 | 3.6 | CC(C)C[C@@H](NC(=O)N1CCC(n2c(=O)[nH]c3ccccc32)CC1)C(=O)N1CCC(N2CCCCC2)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059786 | 83228 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 524 | 6 | 2 | 5 | 3.6 | CC(C)C[C@@H](NC(=O)N1CCC(n2c(=O)[nH]c3ccccc32)CC1)C(=O)N1CCC(N2CCCCC2)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| 44420255 | 144663 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 483 | 4 | 2 | 8 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ncccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL376292 | 144663 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 483 | 4 | 2 | 8 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ncccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| 45485609 | 205223 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 530 | 5 | 2 | 4 | 3.7 | CN1C(=O)NC(=O)C12Cc1ccc(NC(=O)CN(Cc3ccc(C(F)(F)F)cc3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| CHEMBL577304 | 205223 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 530 | 5 | 2 | 4 | 3.7 | CN1C(=O)NC(=O)C12Cc1ccc(NC(=O)CN(Cc3ccc(C(F)(F)F)cc3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| 45254862 | 133752 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 534 | 5 | 2 | 8 | 3.3 | O=C(Cn1c(=O)n(-c2nccs2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)N=C(c2ccccc2)NC1=O | nan | |||
| CHEMBL3655563 | 133752 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 534 | 5 | 2 | 8 | 3.3 | O=C(Cn1c(=O)n(-c2nccs2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)N=C(c2ccccc2)NC1=O | nan | |||
| 70682194 | 83240 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 634 | 7 | 2 | 5 | 5.4 | O=C(N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059800 | 83240 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 634 | 7 | 2 | 5 | 5.4 | O=C(N[C@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| 70690617 | 83252 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 612 | 6 | 3 | 5 | 4.2 | O=C(N[C@@H](Cc1ccc2[nH]ncc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059852 | 83252 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 612 | 6 | 3 | 5 | 4.2 | O=C(N[C@@H](Cc1ccc2[nH]ncc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| 44563027 | 193423 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4cccc(Cl)c43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL488066 | 193423 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4cccc(Cl)c43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| 135461116 | 148331 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 603 | 5 | 2 | 7 | 4.8 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2nc(-c3ccccc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL384799 | 148331 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 603 | 5 | 2 | 7 | 4.8 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2nc(-c3ccccc3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 44562937 | 185872 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 435 | 4 | 3 | 6 | 1.0 | COc1cccc2c1[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL471704 | 185872 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 435 | 4 | 3 | 6 | 1.0 | COc1cccc2c1[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | |||
| 44563089 | 192939 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 491 | 5 | 3 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)O | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL487240 | 192939 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 491 | 5 | 3 | 7 | 1.2 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2CC(=O)O | 10.1016/j.bmcl.2008.10.019 | |||
| 59554942 | 111930 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 541 | 6 | 1 | 5 | 4.7 | O=C(CC1SC(c2ccccc2)N(Cc2cccnc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114468 | 111930 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 541 | 6 | 1 | 5 | 4.7 | O=C(CC1SC(c2ccccc2)N(Cc2cccnc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 44416514 | 162514 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 654 | 5 | 2 | 8 | 4.3 | CS(=O)(=O)c1ccc2c(c1)nc(O)n2C1CCN(C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(F)(F)F)C2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL405544 | 162514 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 654 | 5 | 2 | 8 | 4.3 | CS(=O)(=O)c1ccc2c(c1)nc(O)n2C1CCN(C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(F)(F)F)C2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 44570462 | 190704 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 492 | 5 | 2 | 7 | 2.6 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)C[C@@]1(C2)N=C(C2CC2)NC1=O | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL481382 | 190704 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 492 | 5 | 2 | 7 | 2.6 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)C[C@@]1(C2)N=C(C2CC2)NC1=O | 10.1016/j.bmcl.2008.10.106 | |||
| 45254859 | 133754 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 492 | 5 | 2 | 7 | 2.6 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)N=C(C2CC2)NC1=O | nan | |||
| CHEMBL3655565 | 133754 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 492 | 5 | 2 | 7 | 2.6 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)N=C(C2CC2)NC1=O | nan | |||
| 71569374 | 94449 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 626 | 6 | 3 | 5 | 4.5 | Cc1cc(C[C@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.01.011 | |||
| CHEMBL2336423 | 94449 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 626 | 6 | 3 | 5 | 4.5 | Cc1cc(C[C@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12 | 10.1016/j.bmcl.2013.01.011 | |||
| 11541725 | 148164 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 603 | 5 | 2 | 7 | 4.8 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccccn3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL383872 | 148164 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 603 | 5 | 2 | 7 | 4.8 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2cc(-c3ccccn3)nc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 44417050 | 148287 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 626 | 4 | 2 | 6 | 6.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3c4ccccc4ccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL384539 | 148287 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 626 | 4 | 2 | 6 | 6.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3c4ccccc4ccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 11848647 | 162142 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 445 | 3 | 2 | 7 | 2.4 | Cn1cc(-c2cccnc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL403373 | 162142 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 445 | 3 | 2 | 7 | 2.4 | Cn1cc(-c2cccnc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 11576078 | 185149 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 453 | 4 | 2 | 6 | 2.4 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(CCNC1=O)C2 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL465280 | 185149 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 453 | 4 | 2 | 6 | 2.4 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(CCNC1=O)C2 | 10.1016/j.bmcl.2008.10.106 | |||
| 44570421 | 184529 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 467 | 4 | 2 | 6 | 2.8 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(CCCNC1=O)C2 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL464264 | 184529 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 467 | 4 | 2 | 6 | 2.8 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(CCCNC1=O)C2 | 10.1016/j.bmcl.2008.10.106 | |||
| 24863246 | 83274 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 626 | 6 | 3 | 5 | 4.5 | Cc1nc2cc(C[C@@H](NC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N3CCC(N4CCCCC4)CC3)ccc2[nH]1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059879 | 83274 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 626 | 6 | 3 | 5 | 4.5 | Cc1nc2cc(C[C@@H](NC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N3CCC(N4CCCCC4)CC3)ccc2[nH]1 | 10.1016/j.bmcl.2012.05.074 | |||
| 10340395 | 91770 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 391 | 3 | 4 | 5 | 0.6 | O=C(Cn1c(=O)[nH]c2ccccc21)Nc1ccc2c(c1)CC1(C2)NC(=O)NC1=O | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL223805 | 91770 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 391 | 3 | 4 | 5 | 0.6 | O=C(Cn1c(=O)[nH]c2ccccc21)Nc1ccc2c(c1)CC1(C2)NC(=O)NC1=O | 10.1016/j.bmcl.2006.09.045 | |||
| 11238717 | 148658 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 594 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3cc(F)ccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL386706 | 148658 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 594 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3cc(F)ccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 76310551 | 111984 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 662 | 9 | 2 | 4 | 6.1 | CC(C)CCN(Cc1cc(Br)c(O)c(Br)c1)C(=O)CCC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114678 | 111984 | 0 | None | - | 1 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 662 | 9 | 2 | 4 | 6.1 | CC(C)CCN(Cc1cc(Br)c(O)c(Br)c1)C(=O)CCC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 44416824 | 87058 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 542 | 4 | 2 | 5 | 2.5 | O=C1CN(C2CCN(C(=O)N[C@@H]3N=C(c4ccccc4)c4ccccc4N(CC(F)(F)F)C3=O)CC2)C(=O)N1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL213976 | 87058 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 542 | 4 | 2 | 5 | 2.5 | O=C1CN(C2CCN(C(=O)N[C@@H]3N=C(c4ccccc4)c4ccccc4N(CC(F)(F)F)C3=O)CC2)C(=O)N1 | 10.1016/j.bmcl.2006.07.044 | |||
| 44420231 | 143821 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 517 | 4 | 2 | 6 | 2.7 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4cc(F)cc(F)c4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL374666 | 143821 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 517 | 4 | 2 | 6 | 2.7 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4cc(F)cc(F)c4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| 46182711 | 133760 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 583 | 5 | 3 | 5 | 3.8 | O=C(CN1C(=O)C2(CCCC2)NC[C@H]1c1cc(F)cc(F)c1)Nc1ccc2c(c1)CC1(C2)N=C(c2ccccc2)NC1=O | nan | |||
| CHEMBL3655571 | 133760 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 583 | 5 | 3 | 5 | 3.8 | O=C(CN1C(=O)C2(CCCC2)NC[C@H]1c1cc(F)cc(F)c1)Nc1ccc2c(c1)CC1(C2)N=C(c2ccccc2)NC1=O | nan | |||
| 11978083 | 189671 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 556 | 3 | 4 | 5 | 2.8 | O=C(N[C@@H]1Cc2ccc3[nH]ncc3c2CN(C2CCNCC2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4792127 | 189671 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 556 | 3 | 4 | 5 | 2.8 | O=C(N[C@@H]1Cc2ccc3[nH]ncc3c2CN(C2CCNCC2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| 11671386 | 148197 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 570 | 5 | 3 | 7 | 3.4 | O=C(O)c1cn(C2CCN(C(=O)N[C@@H]3N=C(c4ccccc4)c4ccccc4N(CC(F)(F)F)C3=O)CC2)c(O)n1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL384091 | 148197 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 570 | 5 | 3 | 7 | 3.4 | O=C(O)c1cn(C2CCN(C(=O)N[C@@H]3N=C(c4ccccc4)c4ccccc4N(CC(F)(F)F)C3=O)CC2)c(O)n1 | 10.1016/j.bmcl.2006.07.044 | |||
| 11456102 | 86820 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 591 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3cccnc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL212942 | 86820 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 591 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3cccnc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 76325057 | 111924 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 554 | 6 | 1 | 4 | 5.8 | CC(c1ccccc1)N1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114462 | 111924 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 554 | 6 | 1 | 4 | 5.8 | CC(c1ccccc1)N1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| 59555036 | 111944 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 674 | 10 | 1 | 6 | 6.4 | CCCCN1CCN(c2ccccc2C2SC(CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114482 | 111944 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 674 | 10 | 1 | 6 | 6.4 | CCCCN1CCN(c2ccccc2C2SC(CC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)N2CCC(C)(C)C)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 46885184 | 15111 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 482 | 2 | 1 | 7 | 1.4 | CN1C(=O)Cn2c(=O)n(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)NC(=O)N3C)c3cccc1c32 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1092883 | 15111 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 482 | 2 | 1 | 7 | 1.4 | CN1C(=O)Cn2c(=O)n(Cc3ccc4cc5c(cc4n3)C[C@@]3(C5)C(=O)NC(=O)N3C)c3cccc1c32 | 10.1016/j.bmcl.2010.02.086 | |||
| 11691938 | 68259 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 507 | 3 | 2 | 6 | 3.9 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2ccnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770558 | 68259 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 507 | 3 | 2 | 6 | 3.9 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2ccnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| 11678239 | 68261 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 537 | 4 | 3 | 7 | 3.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2cc(CO)nc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770560 | 68261 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 537 | 4 | 3 | 7 | 3.4 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2cc(CO)nc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| 23658195 | 188153 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 574 | 4 | 2 | 5 | 4.2 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4763305 | 188153 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 574 | 4 | 2 | 5 | 4.2 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| 6918509 | 83817 | 41 | None | -131 | 2 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm500364u | |||
| CHEMBL207197 | 83817 | 41 | None | -131 | 2 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1021/jm500364u | |||
| 57977652 | 81861 | 0 | None | -85 | 2 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 571 | 4 | 3 | 5 | 3.9 | C[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | |||
| CHEMBL2035981 | 81861 | 0 | None | -85 | 2 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 571 | 4 | 3 | 5 | 3.9 | C[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | |||
| 6918509 | 83817 | 41 | None | -131 | 2 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2012.04.105 | |||
| CHEMBL207197 | 83817 | 41 | None | -131 | 2 | Rat | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 867 | 12 | 5 | 8 | 4.4 | NCCCC[C@H](NC(=O)[C@@H](Cc1cc(Br)c(O)c(Br)c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1)C(=O)N1CCN(c2ccncc2)CC1 | 10.1016/j.bmcl.2012.04.105 | |||
| 11526993 | 204371 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 565 | 3 | 2 | 4 | 4.1 | O=C1CC2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)c2cccnc2N1 | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL570531 | 204371 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 565 | 3 | 2 | 4 | 4.1 | O=C1CC2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)c2cccnc2N1 | 10.1016/j.bmcl.2009.09.066 | |||
| 11397560 | 96483 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 484 | 3 | 3 | 5 | 2.4 | O=C1NC[C@H](c2cccc(F)c2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL237661 | 96483 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 484 | 3 | 3 | 5 | 2.4 | O=C1NC[C@H](c2cccc(F)c2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 11562434 | 186106 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 502 | 4 | 2 | 7 | 3.2 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL473445 | 186106 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 502 | 4 | 2 | 7 | 3.2 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2008.10.106 | |||
| 45485654 | 204364 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 5 | 2 | 4 | 2.9 | CN1C(=O)NC(=O)C12Cc1ccc(NC(=O)CN(Cc3ccc(F)cc3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| CHEMBL570488 | 204364 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 480 | 5 | 2 | 4 | 2.9 | CN1C(=O)NC(=O)C12Cc1ccc(NC(=O)CN(Cc3ccc(F)cc3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| 11699891 | 68260 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 589 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2cc(CC(F)(F)F)nc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770559 | 68260 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 589 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)Cn2cc(CC(F)(F)F)nc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| 59555277 | 111934 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 570 | 6 | 1 | 4 | 5.8 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccc(F)cc1F | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114472 | 111934 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 570 | 6 | 1 | 4 | 5.8 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccc(F)cc1F | 10.1016/j.bmcl.2013.12.089 | |||
| 11548734 | 205203 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 577 | 4 | 2 | 4 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)N=C(c1ccccc1)NC2=O | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL577110 | 205203 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 577 | 4 | 2 | 4 | 3.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)N=C(c1ccccc1)NC2=O | 10.1016/j.bmcl.2009.09.066 | |||
| 70690613 | 83229 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 558 | 6 | 2 | 5 | 3.8 | O=C(N[C@H](Cc1ccccc1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059787 | 83229 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 558 | 6 | 2 | 5 | 3.8 | O=C(N[C@H](Cc1ccccc1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| 59554876 | 111923 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 549 | 9 | 1 | 5 | 4.4 | CCN(CC)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114461 | 111923 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 549 | 9 | 1 | 5 | 4.4 | CCN(CC)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| 10340456 | 90284 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 392 | 3 | 3 | 6 | 0.9 | O=C(Cn1c(=O)oc2ccccc21)Nc1ccc2c(c1)CC1(C2)NC(=O)NC1=O | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL220336 | 90284 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 392 | 3 | 3 | 6 | 0.9 | O=C(Cn1c(=O)oc2ccccc21)Nc1ccc2c(c1)CC1(C2)NC(=O)NC1=O | 10.1016/j.bmcl.2006.09.045 | |||
| 44563124 | 195850 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 476 | 6 | 3 | 7 | 0.3 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(CCC(N)=O)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL509718 | 195850 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 476 | 6 | 3 | 7 | 0.3 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(CCC(N)=O)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| 10483685 | 83243 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 597 | 6 | 3 | 5 | 4.2 | O=C(NC(Cc1ccc2[nH]ccc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059803 | 83243 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 597 | 6 | 3 | 5 | 4.2 | O=C(NC(Cc1ccc2[nH]ccc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| 59554982 | 111919 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 506 | 6 | 1 | 4 | 4.7 | CC(C)CN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114457 | 111919 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 506 | 6 | 1 | 4 | 4.7 | CC(C)CN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| 24853374 | 111985 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 520 | 7 | 1 | 4 | 5.1 | CC(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114679 | 111985 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 520 | 7 | 1 | 4 | 5.1 | CC(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| 44562936 | 185715 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 423 | 3 | 3 | 5 | 1.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4c(F)cccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL470321 | 185715 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 423 | 3 | 3 | 5 | 1.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4c(F)cccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| 11330786 | 145166 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 591 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3cnccc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL377252 | 145166 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 591 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3cnccc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 46884948 | 14587 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 479 | 3 | 2 | 7 | 2.1 | CN1C(=O)NC(=O)[C@@]12Cc1cc3nc(Cn4c(=O)n(-c5ccccn5)c5ccccc54)[nH]c3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| 57774187 | 14587 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 479 | 3 | 2 | 7 | 2.1 | CN1C(=O)NC(=O)[C@@]12Cc1cc3nc(Cn4c(=O)n(-c5ccccn5)c5ccccc54)[nH]c3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1089497 | 14587 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 479 | 3 | 2 | 7 | 2.1 | CN1C(=O)NC(=O)[C@@]12Cc1cc3nc(Cn4c(=O)n(-c5ccccn5)c5ccccc54)[nH]c3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| 11520022 | 87339 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 604 | 5 | 2 | 4 | 4.7 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2CC(c3ccccc3)NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL214904 | 87339 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 604 | 5 | 2 | 4 | 4.7 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2CC(c3ccccc3)NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 44570422 | 197490 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 528 | 5 | 2 | 7 | 3.2 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)C[C@@]1(C2)N=C(c2ccccc2)NC1=O | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL518236 | 197490 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 528 | 5 | 2 | 7 | 3.2 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)C[C@@]1(C2)N=C(c2ccccc2)NC1=O | 10.1016/j.bmcl.2008.10.106 | |||
| 45487016 | 204564 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 530 | 3 | 2 | 4 | 2.8 | O=C1CCC2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)C(=O)N1 | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL571861 | 204564 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 530 | 3 | 2 | 4 | 2.8 | O=C1CCC2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)C(=O)N1 | 10.1016/j.bmcl.2009.09.066 | |||
| 44455348 | 162063 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 509 | 6 | 2 | 5 | 5.0 | O=C(Nc1ccc(-c2ccccc2)n(CC2CC2)c1=O)N1CCC(n2cc(-c3ccccc3)[nH]c2=O)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL402888 | 162063 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 509 | 6 | 2 | 5 | 5.0 | O=C(Nc1ccc(-c2ccccc2)n(CC2CC2)c1=O)N1CCC(n2cc(-c3ccccc3)[nH]c2=O)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| 23627980 | 24972 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 470 | 4 | 1 | 4 | 3.8 | CN1C(=O)NC(=O)C12Cc1cc3cc(CN(Cc4ccccc4)C(=O)C(C)(C)C)cnc3cc1C2 | 10.1016/j.bmcl.2010.08.105 | |||
| CHEMBL1269978 | 24972 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 470 | 4 | 1 | 4 | 3.8 | CN1C(=O)NC(=O)C12Cc1cc3cc(CN(Cc4ccccc4)C(=O)C(C)(C)C)cnc3cc1C2 | 10.1016/j.bmcl.2010.08.105 | |||
| 44570536 | 190652 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 474 | 3 | 2 | 5 | 1.7 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)CN3C(=O)C4(CCOCC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL480999 | 190652 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 474 | 3 | 2 | 5 | 1.7 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)CN3C(=O)C4(CCOCC4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.106 | |||
| 45254663 | 133757 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 528 | 5 | 2 | 7 | 3.2 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)N=C(c2ccccc2)NC1=O | nan | |||
| CHEMBL3655568 | 133757 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 528 | 5 | 2 | 7 | 3.2 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)N=C(c2ccccc2)NC1=O | nan | |||
| 11157626 | 173215 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 591 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3ccncc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL427743 | 173215 | 0 | None | - | 1 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 591 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3ccncc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 44563125 | 180606 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 504 | 6 | 2 | 7 | 0.9 | CN(C)C(=O)CCn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2ccccc21 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL453865 | 180606 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 504 | 6 | 2 | 7 | 0.9 | CN(C)C(=O)CCn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2ccccc21 | 10.1016/j.bmcl.2008.10.019 | |||
| 23656918 | 98569 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NCC(c2ccccc2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL241118 | 98569 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NCC(c2ccccc2F)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 44563091 | 199319 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 462 | 5 | 3 | 7 | -0.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(CC(N)=O)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL521076 | 199319 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 462 | 5 | 3 | 7 | -0.1 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(CC(N)=O)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| 11977861 | 189986 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 487 | 2 | 3 | 4 | 2.7 | CN1Cc2c(ccc3[nH]ncc23)C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4795912 | 189986 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 487 | 2 | 3 | 4 | 2.7 | CN1Cc2c(ccc3[nH]ncc23)C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| 44416436 | 87330 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 594 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3c(F)cccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL214873 | 87330 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 594 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3c(F)cccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 70692303 | 81862 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 558 | 4 | 3 | 6 | 3.2 | O=C(CN1C(=O)C2(CCCC2)NC[C@H]1c1cc(F)cc(F)c1)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | |||
| CHEMBL2035982 | 81862 | 0 | None | - | 1 | Rat | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 558 | 4 | 3 | 6 | 3.2 | O=C(CN1C(=O)C2(CCCC2)NC[C@H]1c1cc(F)cc(F)c1)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | |||
| 44420228 | 91012 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 405 | 3 | 3 | 5 | 1.0 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL221009 | 91012 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 405 | 3 | 3 | 5 | 1.0 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccccc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| 11599531 | 205225 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 578 | 4 | 2 | 3 | 4.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)CC(c1ccccc1)NC2=O | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL577320 | 205225 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 578 | 4 | 2 | 3 | 4.7 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC2(CC1)CC(c1ccccc1)NC2=O | 10.1016/j.bmcl.2009.09.066 | |||
| 44416488 | 144469 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 644 | 4 | 2 | 6 | 5.9 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3cc(C(F)(F)F)ccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL375872 | 144469 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 644 | 4 | 2 | 6 | 5.9 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3cc(C(F)(F)F)ccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 44454954 | 102160 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 494 | 6 | 2 | 8 | 3.1 | COCCn1cc(-c2ccsc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL256813 | 102160 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 494 | 6 | 2 | 8 | 3.1 | COCCn1cc(-c2ccsc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 45487042 | 204370 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 530 | 3 | 2 | 4 | 2.8 | O=C1CC2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)CC(=O)N1 | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL570527 | 204370 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 530 | 3 | 2 | 4 | 2.8 | O=C1CC2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)CC(=O)N1 | 10.1016/j.bmcl.2009.09.066 | |||
| 11692140 | 68262 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 521 | 3 | 2 | 6 | 4.2 | Cc1cn2c(n1)[C@H](NC(=O)N1CCC(n3c(=O)[nH]c4ncccc43)CC1)CC[C@@H](c1cccc(F)c1F)C2 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770561 | 68262 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 521 | 3 | 2 | 6 | 4.2 | Cc1cn2c(n1)[C@H](NC(=O)N1CCC(n3c(=O)[nH]c4ncccc43)CC1)CC[C@@H](c1cccc(F)c1F)C2 | 10.1016/j.bmcl.2010.12.054 | |||
| 23656920 | 95923 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 528 | 5 | 3 | 6 | 2.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCO)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL236590 | 95923 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 528 | 5 | 3 | 6 | 2.1 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CCO)C1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 51357854 | 89336 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 535 | 3 | 2 | 7 | 4.5 | O=C(O[C@@H]1CC[C@@H](c2cccc(F)c2F)[C@@H](O)c2cccnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm3013147 | |||
| CHEMBL2178423 | 89336 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 535 | 3 | 2 | 7 | 4.5 | O=C(O[C@@H]1CC[C@@H](c2cccc(F)c2F)[C@@H](O)c2cccnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm3013147 | |||
| 44563090 | 193427 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 510 | 4 | 2 | 7 | 2.5 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2-c1ccccn1 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL488083 | 193427 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 510 | 4 | 2 | 7 | 2.5 | Cc1cc(C)c2c(c1)n(CC(=O)Nc1ccc3c(c1)C[C@]1(C3)C(=O)NC(=O)N1C)c(=O)n2-c1ccccn1 | 10.1016/j.bmcl.2008.10.019 | |||
| 45485666 | 204200 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 530 | 5 | 2 | 4 | 4.0 | CN1C(=O)NC(=O)[C@@]12Cc1ccc(NC(=O)CN(Cc3cc(Cl)cc(Cl)c3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| CHEMBL569588 | 204200 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 530 | 5 | 2 | 4 | 4.0 | CN1C(=O)NC(=O)[C@@]12Cc1ccc(NC(=O)CN(Cc3cc(Cl)cc(Cl)c3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| 44563162 | 181356 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 488 | 3 | 3 | 7 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n4c5c(cccc53)NC(=O)CCC4)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL455674 | 181356 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 488 | 3 | 3 | 7 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n4c5c(cccc53)NC(=O)CCC4)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| 25119463 | 187833 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 543 | 3 | 3 | 4 | 4.1 | CC(C)(C)CN1Cc2c(ccc3[nH]ncc23)C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4759604 | 187833 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 543 | 3 | 3 | 4 | 4.1 | CC(C)(C)CN1Cc2c(ccc3[nH]ncc23)C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| 23656922 | 175635 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 555 | 6 | 2 | 6 | 2.7 | CN(C)CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | |||
| CHEMBL438120 | 175635 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 555 | 6 | 2 | 6 | 2.7 | CN(C)CCN1C[C@H](c2cccc(F)c2F)CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C1=O | 10.1021/jm070668p | |||
| 59554885 | 111941 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 600 | 7 | 1 | 6 | 5.7 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1-n1cccn1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114479 | 111941 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 600 | 7 | 1 | 6 | 5.7 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1-n1cccn1 | 10.1016/j.bmcl.2013.12.089 | |||
| 11848908 | 102220 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 524 | 6 | 2 | 7 | 3.3 | COCCn1cc(-c2cccc(F)c2F)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL257094 | 102220 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 524 | 6 | 2 | 7 | 3.3 | COCCn1cc(-c2cccc(F)c2F)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 44562896 | 185822 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 419 | 3 | 3 | 5 | 1.3 | Cc1cccc2c1[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL471359 | 185822 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 419 | 3 | 3 | 5 | 1.3 | Cc1cccc2c1[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | |||
| 45487057 | 204587 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 516 | 3 | 2 | 4 | 2.4 | O=C1CC2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)C(=O)N1 | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL572114 | 204587 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 516 | 3 | 2 | 4 | 2.4 | O=C1CC2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)C(=O)N1 | 10.1016/j.bmcl.2009.09.066 | |||
| 11848966 | 102177 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 530 | 4 | 2 | 6 | 4.1 | O=C(Nc1cc(-c2cccc(F)c2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL256901 | 102177 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 530 | 4 | 2 | 6 | 4.1 | O=C(Nc1cc(-c2cccc(F)c2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| 44455153 | 104243 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 460 | 3 | 3 | 7 | 2.7 | Cn1cc(-c2cccc(O)c2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL270175 | 104243 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 460 | 3 | 3 | 7 | 2.7 | Cn1cc(-c2cccc(O)c2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 11215322 | 148556 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 577 | 4 | 2 | 7 | 4.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3cccnc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL386113 | 148556 | 0 | None | - | 1 | Human | 6.4 | pKi | = | 6.4 | Binding | ChEMBL | 577 | 4 | 2 | 7 | 4.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3cccnc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 11848646 | 104285 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 460 | 3 | 3 | 7 | 2.7 | Cn1cc(-c2ccc(O)cc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL270390 | 104285 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 460 | 3 | 3 | 7 | 2.7 | Cn1cc(-c2ccc(O)cc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 44420228 | 91012 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 405 | 3 | 3 | 5 | 1.0 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL221009 | 91012 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 405 | 3 | 3 | 5 | 1.0 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| 23656586 | 161173 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 449 | 3 | 3 | 6 | 1.5 | O=C1NCC(c2ccccn2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL398779 | 161173 | 0 | None | - | 1 | Human | 5.4 | pKi | = | 5.4 | Binding | ChEMBL | 449 | 3 | 3 | 6 | 1.5 | O=C1NCC(c2ccccn2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 59555326 | 111917 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 504 | 6 | 1 | 4 | 4.5 | O=C(CC1SC(c2ccccc2)N(CC2CC2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114455 | 111917 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 504 | 6 | 1 | 4 | 4.5 | O=C(CC1SC(c2ccccc2)N(CC2CC2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 45485590 | 204463 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 492 | 6 | 2 | 5 | 2.7 | COc1cccc(CN(CC(=O)Nc2ccc3c(c2)CC2(C3)C(=O)NC(=O)N2C)C(=O)C(C)(C)C)c1 | 10.1016/j.bmcl.2009.07.134 | |||
| CHEMBL571137 | 204463 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 492 | 6 | 2 | 5 | 2.7 | COc1cccc(CN(CC(=O)Nc2ccc3c(c2)CC2(C3)C(=O)NC(=O)N2C)C(=O)C(C)(C)C)c1 | 10.1016/j.bmcl.2009.07.134 | |||
| 11555955 | 204504 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 566 | 3 | 2 | 4 | 4.9 | O=C1Nc2ccccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)O1 | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL571459 | 204504 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 566 | 3 | 2 | 4 | 4.9 | O=C1Nc2ccccc2C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)O1 | 10.1016/j.bmcl.2009.09.066 | |||
| 11706251 | 205304 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 517 | 3 | 3 | 4 | 2.0 | O=C1NC(=O)C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)N1 | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL577957 | 205304 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 517 | 3 | 3 | 4 | 2.0 | O=C1NC(=O)C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)N1 | 10.1016/j.bmcl.2009.09.066 | |||
| 23656749 | 98355 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 454 | 3 | 3 | 6 | 2.2 | O=C1NCC(c2ccsc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL240686 | 98355 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 454 | 3 | 3 | 6 | 2.2 | O=C1NCC(c2ccsc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 23656752 | 98520 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 414 | 3 | 3 | 5 | 1.6 | CC(C)C1CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C(=O)NC1 | 10.1021/jm070668p | |||
| CHEMBL240904 | 98520 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 414 | 3 | 3 | 5 | 1.6 | CC(C)C1CC[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)C(=O)NC1 | 10.1021/jm070668p | |||
| 11410749 | 172608 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 590 | 4 | 2 | 4 | 5.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL424864 | 172608 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 590 | 4 | 2 | 4 | 5.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 44420287 | 90214 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 406 | 3 | 2 | 6 | 1.3 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)oc4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL219782 | 90214 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 406 | 3 | 2 | 6 | 1.3 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)oc4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| 11848755 | 102154 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 474 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2cc(NC(=O)N3CCC(n4c(=O)[nH]c5ncccc54)CC3)c(=O)n(C)c2)cc1 | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL256802 | 102154 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 474 | 4 | 2 | 7 | 3.0 | COc1ccc(-c2cc(NC(=O)N3CCC(n4c(=O)[nH]c5ncccc54)CC3)c(=O)n(C)c2)cc1 | 10.1016/j.bmcl.2007.11.042 | |||
| 11495985 | 102445 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 444 | 3 | 2 | 6 | 3.0 | Cn1cc(-c2ccccc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL258070 | 102445 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 444 | 3 | 2 | 6 | 3.0 | Cn1cc(-c2ccccc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 44562895 | 185821 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 433 | 3 | 3 | 5 | 1.6 | Cc1cc(C)c2[nH]c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c2c1 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL471358 | 185821 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 433 | 3 | 3 | 5 | 1.6 | Cc1cc(C)c2[nH]c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c2c1 | 10.1016/j.bmcl.2008.10.019 | |||
| 54582784 | 68265 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 564 | 6 | 3 | 7 | 3.6 | CNCCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| CHEMBL1770564 | 68265 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 564 | 6 | 3 | 7 | 3.6 | CNCCc1cnc2n1C[C@H](c1cccc(F)c1F)CC[C@H]2NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2010.12.054 | |||
| 11977972 | 188670 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 586 | 5 | 3 | 6 | 2.4 | O=C(N[C@@H]1Cc2ccc3[nH]ncc3c2CN(CCN2CCOCC2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4779094 | 188670 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 586 | 5 | 3 | 6 | 2.4 | O=C(N[C@@H]1Cc2ccc3[nH]ncc3c2CN(CCN2CCOCC2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| 45487060 | 204406 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 449 | 3 | 2 | 3 | 2.8 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(O)CC1 | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL570750 | 204406 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 449 | 3 | 2 | 3 | 2.8 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(O)CC1 | 10.1016/j.bmcl.2009.09.066 | |||
| 11454113 | 152530 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NC[C@H](c2cccc(F)c2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL391660 | 152530 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NC[C@H](c2cccc(F)c2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 11786529 | 146309 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 578 | 4 | 2 | 8 | 3.7 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncncc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL379548 | 146309 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 578 | 4 | 2 | 8 | 3.7 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ncncc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 45487055 | 205738 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 531 | 3 | 2 | 4 | 2.3 | CN1C(=O)NC(=O)C12CCN(C(=O)N[C@@H]1CC[C@@H](c3cccc(F)c3F)CN(CC(F)(F)F)C1=O)CC2 | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL585017 | 205738 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 531 | 3 | 2 | 4 | 2.3 | CN1C(=O)NC(=O)C12CCN(C(=O)N[C@@H]1CC[C@@H](c3cccc(F)c3F)CN(CC(F)(F)F)C1=O)CC2 | 10.1016/j.bmcl.2009.09.066 | |||
| 59555260 | 111937 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 619 | 7 | 1 | 6 | 5.3 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCOCC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114475 | 111937 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 619 | 7 | 1 | 6 | 5.3 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCOCC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 44416824 | 87058 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 542 | 4 | 2 | 5 | 2.5 | O=C1CN(C2CCN(C(=O)N[C@@H]3N=C(c4ccccc4)c4ccccc4N(CC(F)(F)F)C3=O)CC2)C(=O)N1 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL213976 | 87058 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 542 | 4 | 2 | 5 | 2.5 | O=C1CN(C2CCN(C(=O)N[C@@H]3N=C(c4ccccc4)c4ccccc4N(CC(F)(F)F)C3=O)CC2)C(=O)N1 | 10.1016/j.bmcl.2008.10.106 | |||
| 44570463 | 196423 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 501 | 4 | 2 | 6 | 3.8 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)C(=O)Nc2ccccc21 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL515087 | 196423 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 501 | 4 | 2 | 6 | 3.8 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)C(=O)Nc2ccccc21 | 10.1016/j.bmcl.2008.10.106 | |||
| 11570464 | 148440 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 568 | 5 | 2 | 6 | 4.8 | CC(C)c1cn(C2CCN(C(=O)N[C@@H]3N=C(c4ccccc4)c4ccccc4N(CC(F)(F)F)C3=O)CC2)c(O)n1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL385399 | 148440 | 0 | None | - | 1 | Human | 5.3 | pKi | = | 5.3 | Binding | ChEMBL | 568 | 5 | 2 | 6 | 4.8 | CC(C)c1cn(C2CCN(C(=O)N[C@@H]3N=C(c4ccccc4)c4ccccc4N(CC(F)(F)F)C3=O)CC2)c(O)n1 | 10.1016/j.bmcl.2006.07.044 | |||
| 59554953 | 111932 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 552 | 6 | 1 | 4 | 5.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1F | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114470 | 111932 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 552 | 6 | 1 | 4 | 5.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1F | 10.1016/j.bmcl.2013.12.089 | |||
| 11848965 | 173478 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 530 | 4 | 2 | 6 | 4.1 | O=C(Nc1cc(-c2ccccc2F)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL428247 | 173478 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 530 | 4 | 2 | 6 | 4.1 | O=C(Nc1cc(-c2ccccc2F)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| 46884946 | 15153 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 500 | 4 | 2 | 7 | 2.0 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)c(F)c1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1093189 | 15153 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 500 | 4 | 2 | 7 | 2.0 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)c(F)c1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| 59554924 | 111929 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 558 | 6 | 1 | 4 | 5.4 | O=C(CC1SC(c2ccccc2)N(Cc2ccc(F)cc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114467 | 111929 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 558 | 6 | 1 | 4 | 5.4 | O=C(CC1SC(c2ccccc2)N(Cc2ccc(F)cc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 45485676 | 204113 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 476 | 5 | 2 | 4 | 3.3 | C[C@@H](c1ccccc1)N(CC(=O)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)NC(=O)N1C)C(=O)C(C)(C)C | 10.1016/j.bmcl.2009.07.134 | |||
| CHEMBL568880 | 204113 | 0 | None | - | 1 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 476 | 5 | 2 | 4 | 3.3 | C[C@@H](c1ccccc1)N(CC(=O)Nc1ccc2c(c1)C[C@@]1(C2)C(=O)NC(=O)N1C)C(=O)C(C)(C)C | 10.1016/j.bmcl.2009.07.134 | |||
| 46179165 | 131966 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 493 | 3 | 2 | 5 | 3.4 | O=C1NCCN(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)C1c1ccc(F)cc1 | nan | |||
| CHEMBL3645146 | 131966 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 493 | 3 | 2 | 5 | 3.4 | O=C1NCCN(Cc2cnc3cc4c(cc3c2)C[C@@]2(C4)C(=O)Nc3ncccc32)C1c1ccc(F)cc1 | nan | |||
| 58432803 | 133753 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 529 | 5 | 2 | 8 | 2.6 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)N=C(c2ccccn2)NC1=O | nan | |||
| CHEMBL3655564 | 133753 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 529 | 5 | 2 | 8 | 2.6 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)N=C(c2ccccn2)NC1=O | nan | |||
| 11713729 | 87325 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 551 | 4 | 2 | 7 | 3.6 | N#Cc1cn(C2CCN(C(=O)N[C@@H]3N=C(c4ccccc4)c4ccccc4N(CC(F)(F)F)C3=O)CC2)c(O)n1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL214845 | 87325 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 551 | 4 | 2 | 7 | 3.6 | N#Cc1cn(C2CCN(C(=O)N[C@@H]3N=C(c4ccccc4)c4ccccc4N(CC(F)(F)F)C3=O)CC2)c(O)n1 | 10.1016/j.bmcl.2006.07.044 | |||
| 11692206 | 86984 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 526 | 4 | 2 | 6 | 3.7 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2ccnc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL213670 | 86984 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 526 | 4 | 2 | 6 | 3.7 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2ccnc2O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 24782724 | 188174 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 515 | 3 | 3 | 4 | 3.4 | CC(C)N1Cc2c(ccc3[nH]ncc23)C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4763543 | 188174 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 515 | 3 | 3 | 4 | 3.4 | CC(C)N1Cc2c(ccc3[nH]ncc23)C[C@@H](NC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| 59555152 | 111935 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 570 | 6 | 1 | 4 | 5.8 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1c(F)cccc1F | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114473 | 111935 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 570 | 6 | 1 | 4 | 5.8 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1c(F)cccc1F | 10.1016/j.bmcl.2013.12.089 | |||
| 59731892 | 187470 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 591 | 4 | 2 | 4 | 5.5 | CC(C)(C)CN1Cc2c(cc(Cl)c3[nH]ncc23)C[C@@H](CC(=O)N2CCC(c3cc4cccc(F)c4[nH]c3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4755474 | 187470 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 591 | 4 | 2 | 4 | 5.5 | CC(C)(C)CN1Cc2c(cc(Cl)c3[nH]ncc23)C[C@@H](CC(=O)N2CCC(c3cc4cccc(F)c4[nH]c3=O)CC2)C1=O | 10.1016/j.bmcl.2020.127624 | |||
| 11977740 | 189199 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 603 | 4 | 2 | 4 | 5.1 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(c2cc3cccc(F)c3[nH]c2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4785845 | 189199 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 603 | 4 | 2 | 4 | 5.1 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(c2cc3cccc(F)c3[nH]c2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| 11585317 | 87693 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 616 | 5 | 2 | 6 | 5.7 | Cc1ccc(-c2cn(C3CCN(C(=O)N[C@@H]4N=C(c5ccccc5)c5ccccc5N(CC(F)(F)F)C4=O)CC3)c(O)n2)cc1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL215325 | 87693 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 616 | 5 | 2 | 6 | 5.7 | Cc1ccc(-c2cn(C3CCN(C(=O)N[C@@H]4N=C(c5ccccc5)c5ccccc5N(CC(F)(F)F)C4=O)CC3)c(O)n2)cc1 | 10.1016/j.bmcl.2006.07.044 | |||
| 45487036 | 204405 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 541 | 4 | 2 | 4 | 3.6 | Cc1cc(C2CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)c(=O)[nH]n1 | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL570748 | 204405 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 541 | 4 | 2 | 4 | 3.6 | Cc1cc(C2CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)c(=O)[nH]n1 | 10.1016/j.bmcl.2009.09.066 | |||
| 44420241 | 143490 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 488 | 4 | 2 | 8 | 1.9 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4cnsc4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL374064 | 143490 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 488 | 4 | 2 | 8 | 1.9 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4cnsc4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| 70683851 | 81866 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 586 | 5 | 3 | 6 | 3.7 | CC[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | |||
| CHEMBL2035986 | 81866 | 0 | None | - | 1 | Rat | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 586 | 5 | 3 | 6 | 3.7 | CC[C@@]1(c2cc(F)cc(F)c2)CNC2(CCCC2)C(=O)N1CC(=O)Nc1cnc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21 | 10.1016/j.bmcl.2012.04.105 | |||
| 46884999 | 14498 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 480 | 3 | 1 | 8 | 2.4 | CN1C(=O)NC(=O)[C@@]12Cc1cc3nc(Cn4c(=O)n(-c5ccccn5)c5ccccc54)oc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1088906 | 14498 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 480 | 3 | 1 | 8 | 2.4 | CN1C(=O)NC(=O)[C@@]12Cc1cc3nc(Cn4c(=O)n(-c5ccccn5)c5ccccc54)oc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| 10453991 | 144658 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 406 | 3 | 3 | 6 | 1.3 | O=C(Cn1c(=O)oc2ccccc21)Nc1ccc2c(c1)CCC1(C2)NC(=O)NC1=O | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL376263 | 144658 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 406 | 3 | 3 | 6 | 1.3 | O=C(Cn1c(=O)oc2ccccc21)Nc1ccc2c(c1)CCC1(C2)NC(=O)NC1=O | 10.1016/j.bmcl.2006.09.045 | |||
| 23656753 | 98568 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 462 | 4 | 3 | 5 | 2.2 | O=C1NCC(Cc2ccccc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL241117 | 98568 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 462 | 4 | 3 | 5 | 2.2 | O=C1NCC(Cc2ccccc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 11444699 | 87280 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 590 | 4 | 2 | 6 | 5.2 | Cc1ccc2c(c1)nc(O)n2C1CCN(C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(F)(F)F)C2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL214751 | 87280 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 590 | 4 | 2 | 6 | 5.2 | Cc1ccc2c(c1)nc(O)n2C1CCN(C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(F)(F)F)C2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 44562983 | 198166 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 435 | 4 | 3 | 6 | 1.0 | COc1ccc2c(c1)[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL519242 | 198166 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 435 | 4 | 3 | 6 | 1.0 | COc1ccc2c(c1)[nH]c(=O)n2CC(=O)Nc1ccc2c(c1)C[C@]1(C2)C(=O)NC(=O)N1C | 10.1016/j.bmcl.2008.10.019 | |||
| 45254858 | 133756 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 530 | 5 | 2 | 9 | 2.0 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)N=C(c2cnccn2)NC1=O | nan | |||
| CHEMBL3655567 | 133756 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 530 | 5 | 2 | 9 | 2.0 | O=C(Cn1c(=O)n(-c2ccccn2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)N=C(c2cnccn2)NC1=O | nan | |||
| 11849023 | 101933 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 513 | 4 | 2 | 7 | 3.4 | O=C(Nc1cc(-c2cccnc2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL255755 | 101933 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 513 | 4 | 2 | 7 | 3.4 | O=C(Nc1cc(-c2cccnc2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| 59554855 | 111918 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 506 | 7 | 1 | 4 | 4.9 | CCCCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114456 | 111918 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 506 | 7 | 1 | 4 | 4.9 | CCCCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| 11215639 | 148295 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 610 | 4 | 2 | 6 | 5.5 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3cccc(Cl)c32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL384565 | 148295 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 610 | 4 | 2 | 6 | 5.5 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3cccc(Cl)c32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 45254860 | 133755 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 494 | 6 | 2 | 7 | 3.0 | CCCC1=NC2(Cc3ccc(NC(=O)Cn4c(=O)n(-c5ccccn5)c5ccccc54)cc3C2)C(=O)N1 | nan | |||
| CHEMBL3655566 | 133755 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 494 | 6 | 2 | 7 | 3.0 | CCCC1=NC2(Cc3ccc(NC(=O)Cn4c(=O)n(-c5ccccn5)c5ccccc54)cc3C2)C(=O)N1 | nan | |||
| 45487061 | 204418 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 582 | 4 | 2 | 5 | 2.9 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3c2ccc[n+]3[O-])CC1 | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL570860 | 204418 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 582 | 4 | 2 | 5 | 2.9 | O=C(N[C@@H]1CC[C@@H](c2cccc(F)c2F)CN(CC(F)(F)F)C1=O)N1CCC(n2c(=O)[nH]c3c2ccc[n+]3[O-])CC1 | 10.1016/j.bmcl.2009.09.066 | |||
| 46884948 | 14587 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 479 | 3 | 2 | 7 | 2.1 | CN1C(=O)NC(=O)[C@@]12Cc1cc3nc(Cn4c(=O)n(-c5ccccn5)c5ccccc54)[nH]c3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| 57774187 | 14587 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 479 | 3 | 2 | 7 | 2.1 | CN1C(=O)NC(=O)[C@@]12Cc1cc3nc(Cn4c(=O)n(-c5ccccn5)c5ccccc54)[nH]c3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1089497 | 14587 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 479 | 3 | 2 | 7 | 2.1 | CN1C(=O)NC(=O)[C@@]12Cc1cc3nc(Cn4c(=O)n(-c5ccccn5)c5ccccc54)[nH]c3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| 24862842 | 83244 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 598 | 6 | 3 | 6 | 3.6 | O=C(NC(Cc1ccc2[nH]ncc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059804 | 83244 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 598 | 6 | 3 | 6 | 3.6 | O=C(NC(Cc1ccc2[nH]ncc2c1)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| 59555024 | 111926 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 534 | 6 | 1 | 5 | 4.2 | O=C(CC1SC(c2ccccc2)N(CC2CCCO2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114464 | 111926 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 534 | 6 | 1 | 5 | 4.2 | O=C(CC1SC(c2ccccc2)N(CC2CCCO2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 11330650 | 168716 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 577 | 4 | 2 | 7 | 4.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3cnccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL415453 | 168716 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 577 | 4 | 2 | 7 | 4.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3cnccc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 11157609 | 148195 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 590 | 4 | 2 | 6 | 5.2 | Cc1cccc2c1nc(O)n2C1CCN(C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(F)(F)F)C2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL384080 | 148195 | 0 | None | - | 1 | Human | 5.2 | pKi | = | 5.2 | Binding | ChEMBL | 590 | 4 | 2 | 6 | 5.2 | Cc1cccc2c1nc(O)n2C1CCN(C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(F)(F)F)C2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 11848857 | 101986 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 489 | 6 | 2 | 8 | 2.5 | COCCn1cc(-c2cccnc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL255999 | 101986 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 489 | 6 | 2 | 8 | 2.5 | COCCn1cc(-c2cccnc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 59555012 | 111940 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 600 | 7 | 1 | 6 | 5.7 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1-n1ccnc1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114478 | 111940 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 600 | 7 | 1 | 6 | 5.7 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1-n1ccnc1 | 10.1016/j.bmcl.2013.12.089 | |||
| 162649395 | 186951 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 578 | 5 | 3 | 5 | 3.7 | O=C(N[C@@H]1Cc2ccc3[nH]ncc3c2CN(CCc2ccncc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4749085 | 186951 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 578 | 5 | 3 | 5 | 3.7 | O=C(N[C@@H]1Cc2ccc3[nH]ncc3c2CN(CCc2ccncc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| 46905052 | 17190 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 488 | 3 | 2 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2C | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL1162991 | 17190 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 488 | 3 | 2 | 7 | 0.7 | Cc1cc2c3c(c1)n(CC(=O)Nc1ccc4c(c1)C[C@]1(C4)C(=O)NC(=O)N1C)c(=O)n3CC(=O)N2C | 10.1016/j.bmcl.2008.10.106 | |||
| 44563161 | 180513 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 474 | 3 | 2 | 7 | 0.4 | CN1C(=O)Cn2c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c3cccc1c32 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL453644 | 180513 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 474 | 3 | 2 | 7 | 0.4 | CN1C(=O)Cn2c(=O)n(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)NC(=O)N3C)c3cccc1c32 | 10.1016/j.bmcl.2008.10.019 | |||
| 70682193 | 83237 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 608 | 6 | 2 | 5 | 4.9 | O=C(N[C@H](Cc1cccc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059798 | 83237 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 608 | 6 | 2 | 5 | 4.9 | O=C(N[C@H](Cc1cccc2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| 45485665 | 204118 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 476 | 5 | 2 | 4 | 3.0 | Cc1cccc(CN(CC(=O)Nc2ccc3c(c2)CC2(C3)C(=O)NC(=O)N2C)C(=O)C(C)(C)C)c1 | 10.1016/j.bmcl.2009.07.134 | |||
| CHEMBL568921 | 204118 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 476 | 5 | 2 | 4 | 3.0 | Cc1cccc(CN(CC(=O)Nc2ccc3c(c2)CC2(C3)C(=O)NC(=O)N2C)C(=O)C(C)(C)C)c1 | 10.1016/j.bmcl.2009.07.134 | |||
| 44455080 | 102403 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 434 | 3 | 2 | 8 | 2.3 | Cn1cc(C2C=CN=N2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL257902 | 102403 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 434 | 3 | 2 | 8 | 2.3 | Cn1cc(C2C=CN=N2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 11527287 | 87322 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 605 | 5 | 2 | 5 | 4.1 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2CC(c3ccncc3)NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL214829 | 87322 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 605 | 5 | 2 | 5 | 4.1 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2CC(c3ccncc3)NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 46884947 | 14586 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 500 | 4 | 2 | 7 | 2.0 | CN1C(=O)NC(=O)[C@]12Cc1cc(F)c(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1089496 | 14586 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 500 | 4 | 2 | 7 | 2.0 | CN1C(=O)NC(=O)[C@]12Cc1cc(F)c(NC(=O)Cn3c(=O)n(-c4ccccn4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| 11848855 | 104364 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 504 | 6 | 3 | 8 | 2.8 | COCCn1cc(-c2ccc(O)cc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL270796 | 104364 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 504 | 6 | 3 | 8 | 2.8 | COCCn1cc(-c2ccc(O)cc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 11848750 | 102362 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 450 | 3 | 2 | 7 | 3.0 | Cn1cc(-c2ccsc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL257731 | 102362 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 450 | 3 | 2 | 7 | 3.0 | Cn1cc(-c2ccsc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 70684297 | 83235 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 573 | 6 | 3 | 6 | 3.3 | Nc1ccc(C[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059796 | 83235 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 573 | 6 | 3 | 6 | 3.3 | Nc1ccc(C[C@@H](NC(=O)N2CCC(n3c(=O)[nH]c4ccccc43)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc1 | 10.1016/j.bmcl.2012.05.074 | |||
| 59555274 | 111921 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 532 | 5 | 1 | 4 | 4.6 | O=C(CC1SC(c2ccccc2)N(CC(F)(F)F)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114459 | 111921 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 532 | 5 | 1 | 4 | 4.6 | O=C(CC1SC(c2ccccc2)N(CC(F)(F)F)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 23656587 | 96996 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 464 | 3 | 4 | 6 | 1.8 | O=C1NCC(c2ccc(O)cc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL238275 | 96996 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 464 | 3 | 4 | 6 | 1.8 | O=C1NCC(c2ccc(O)cc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 9978597 | 148420 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 405 | 3 | 3 | 6 | 0.7 | Cn1c(=O)n(CC(=O)Nc2ccc3c(c2)CC2(C3)NC(=O)NC2=O)c2ccccc21 | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL385322 | 148420 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 405 | 3 | 3 | 6 | 0.7 | Cn1c(=O)n(CC(=O)Nc2ccc3c(c2)CC2(C3)NC(=O)NC2=O)c2ccccc21 | 10.1016/j.bmcl.2006.09.045 | |||
| 59554975 | 111945 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 662 | 9 | 2 | 7 | 4.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCN(CCO)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114483 | 111945 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 662 | 9 | 2 | 7 | 4.6 | CC(C)(C)CCN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1N1CCN(CCO)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 44420236 | 144367 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 488 | 4 | 2 | 8 | 1.9 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4nccs4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL375533 | 144367 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 488 | 4 | 2 | 8 | 1.9 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4nccs4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| 46885133 | 14806 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 426 | 2 | 1 | 4 | 2.7 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(CN4C(=O)CCc5ccccc54)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| CHEMBL1090846 | 14806 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 426 | 2 | 1 | 4 | 2.7 | CN1C(=O)NC(=O)[C@@]12Cc1cc3ccc(CN4C(=O)CCc5ccccc54)nc3cc1C2 | 10.1016/j.bmcl.2010.02.086 | |||
| 11849147 | 102028 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 509 | 6 | 2 | 5 | 5.0 | O=C(Nc1cc(-c2ccccc2)cn(CC2CC2)c1=O)N1CCC(n2cc(-c3ccccc3)[nH]c2=O)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL256203 | 102028 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 509 | 6 | 2 | 5 | 5.0 | O=C(Nc1cc(-c2ccccc2)cn(CC2CC2)c1=O)N1CCC(n2cc(-c3ccccc3)[nH]c2=O)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| 45485621 | 205275 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 462 | 5 | 2 | 4 | 2.7 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)CN(Cc3ccccc3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| CHEMBL577737 | 205275 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 462 | 5 | 2 | 4 | 2.7 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)CN(Cc3ccccc3)C(=O)C(C)(C)C)cc1C2 | 10.1016/j.bmcl.2009.07.134 | |||
| 59555236 | 111928 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 526 | 5 | 1 | 4 | 5.3 | O=C(CC1SC(c2ccccc2)N(c2ccccc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114466 | 111928 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 526 | 5 | 1 | 4 | 5.3 | O=C(CC1SC(c2ccccc2)N(c2ccccc2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 44416512 | 162513 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 620 | 5 | 3 | 7 | 4.6 | O=C(O)c1ccc2c(c1)nc(O)n2C1CCN(C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(F)(F)F)C2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL405543 | 162513 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 620 | 5 | 3 | 7 | 4.6 | O=C(O)c1ccc2c(c1)nc(O)n2C1CCN(C(=O)N[C@@H]2N=C(c3ccccc3)c3ccccc3N(CC(F)(F)F)C2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 11453687 | 174233 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 448 | 3 | 3 | 5 | 2.1 | O=C1NC[C@H](c2ccccc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL429803 | 174233 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 448 | 3 | 3 | 5 | 2.1 | O=C1NC[C@H](c2ccccc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 70696847 | 83241 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 597 | 6 | 3 | 5 | 4.2 | O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| CHEMBL2059801 | 83241 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 597 | 6 | 3 | 5 | 4.2 | O=C(N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC(N2CCCCC2)CC1)N1CCC(n2c(=O)[nH]c3ccccc32)CC1 | 10.1016/j.bmcl.2012.05.074 | |||
| 11342207 | 148317 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 577 | 4 | 2 | 7 | 4.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ccncc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL384723 | 148317 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 577 | 4 | 2 | 7 | 4.3 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ccncc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 11497403 | 172855 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 528 | 4 | 2 | 4 | 3.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2CCNC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL425807 | 172855 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 528 | 4 | 2 | 4 | 3.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2CCNC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 59555111 | 111916 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 490 | 5 | 1 | 4 | 4.2 | O=C(CC1SC(c2ccccc2)N(C2CC2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114454 | 111916 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 490 | 5 | 1 | 4 | 4.2 | O=C(CC1SC(c2ccccc2)N(C2CC2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 44420227 | 90207 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 467 | 4 | 3 | 6 | 2.1 | O=C(Cn1c(=O)n(-c2ccccc2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)NC(=O)NC1=O | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL219721 | 90207 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 467 | 4 | 3 | 6 | 2.1 | O=C(Cn1c(=O)n(-c2ccccc2)c2ccccc21)Nc1ccc2c(c1)CC1(C2)NC(=O)NC1=O | 10.1016/j.bmcl.2006.09.045 | |||
| 24853163 | 111925 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 532 | 5 | 1 | 4 | 5.4 | O=C(CC1SC(c2ccccc2)N(C2CCCCC2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114463 | 111925 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 532 | 5 | 1 | 4 | 5.4 | O=C(CC1SC(c2ccccc2)N(C2CCCCC2)C1=O)N1CCC(N2Cc3ccccc3NC2=O)CC1 | 10.1016/j.bmcl.2013.12.089 | |||
| 45487056 | 204474 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 518 | 3 | 2 | 5 | 2.4 | O=C1NC(=O)C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)O1 | 10.1016/j.bmcl.2009.09.066 | |||
| CHEMBL571236 | 204474 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 518 | 3 | 2 | 5 | 2.4 | O=C1NC(=O)C2(CCN(C(=O)N[C@@H]3CC[C@@H](c4cccc(F)c4F)CN(CC(F)(F)F)C3=O)CC2)O1 | 10.1016/j.bmcl.2009.09.066 | |||
| 76310534 | 111927 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 520 | 5 | 1 | 4 | 5.1 | CC(C)(C)CN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| CHEMBL3114465 | 111927 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 520 | 5 | 1 | 4 | 5.1 | CC(C)(C)CN1C(=O)C(CC(=O)N2CCC(N3Cc4ccccc4NC3=O)CC2)SC1c1ccccc1 | 10.1016/j.bmcl.2013.12.089 | |||
| 23658240 | 188031 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 620 | 4 | 2 | 4 | 4.9 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3cccc(F)c3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| CHEMBL4761776 | 188031 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 620 | 4 | 2 | 4 | 4.9 | O=C(C[C@@H]1Cc2cc(Cl)c3[nH]ncc3c2CN(CC(F)(F)F)C1=O)N1CCC(N2CCc3cccc(F)c3NC2=O)CC1 | 10.1016/j.bmcl.2020.127624 | |||
| 44420260 | 90255 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 483 | 4 | 2 | 8 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4cncnc4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| CHEMBL220146 | 90255 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 483 | 4 | 2 | 8 | 1.2 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)n(-c4cncnc4)c4ccccc43)cc1C2 | 10.1016/j.bmcl.2006.09.045 | |||
| 44562985 | 192941 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccc(Cl)cc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL487244 | 192941 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 439 | 3 | 3 | 5 | 1.6 | CN1C(=O)NC(=O)[C@]12Cc1ccc(NC(=O)Cn3c(=O)[nH]c4ccc(Cl)cc43)cc1C2 | 10.1016/j.bmcl.2008.10.019 | |||
| 44563160 | 181354 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 518 | 7 | 2 | 7 | 1.3 | CN(C)C(=O)CCCn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2ccccc21 | 10.1016/j.bmcl.2008.10.019 | |||
| CHEMBL455670 | 181354 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 518 | 7 | 2 | 7 | 1.3 | CN(C)C(=O)CCCn1c(=O)n(CC(=O)Nc2ccc3c(c2)C[C@]2(C3)C(=O)NC(=O)N2C)c2ccccc21 | 10.1016/j.bmcl.2008.10.019 | |||
| 45273525 | 202465 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 479 | 3 | 2 | 5 | 3.0 | CN1C(=O)C[C@@H]2CN(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)Nc4ncccc43)c3cccc1c32 | 10.1016/j.bmcl.2009.06.057 | |||
| CHEMBL556703 | 202465 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 479 | 3 | 2 | 5 | 3.0 | CN1C(=O)C[C@@H]2CN(CC(=O)Nc3ccc4c(c3)C[C@]3(C4)C(=O)Nc4ncccc43)c3cccc1c32 | 10.1016/j.bmcl.2009.06.057 | |||
| 11848698 | 102195 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 488 | 4 | 3 | 7 | 2.7 | Cn1cc(-c2ccc(C(=O)O)cc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL257004 | 102195 | 0 | None | - | 1 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 488 | 4 | 3 | 7 | 2.7 | Cn1cc(-c2ccc(C(=O)O)cc2)cc(NC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)c1=O | 10.1016/j.bmcl.2007.11.042 | |||
| 23656919 | 161524 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NCC(c2cccc(F)c2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL400020 | 161524 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 466 | 3 | 3 | 5 | 2.3 | O=C1NCC(c2cccc(F)c2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 70694861 | 83357 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 519 | 3 | 1 | 6 | 5.0 | O=C(O[C@H]1CC[C@H](c2cccc(F)c2F)Cc2cccnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/ml300021s | |||
| CHEMBL2063116 | 83357 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 519 | 3 | 1 | 6 | 5.0 | O=C(O[C@H]1CC[C@H](c2cccc(F)c2F)Cc2cccnc21)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/ml300021s | |||
| 11848964 | 101979 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 512 | 4 | 2 | 6 | 4.0 | O=C(Nc1cc(-c2ccccc2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL255966 | 101979 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 512 | 4 | 2 | 6 | 4.0 | O=C(Nc1cc(-c2ccccc2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| 11849020 | 101822 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 528 | 4 | 3 | 7 | 3.7 | O=C(Nc1cc(-c2ccc(O)cc2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| CHEMBL255136 | 101822 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 528 | 4 | 3 | 7 | 3.7 | O=C(Nc1cc(-c2ccc(O)cc2)cn(CC(F)(F)F)c1=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1016/j.bmcl.2007.11.042 | |||
| 11532845 | 184528 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 467 | 4 | 2 | 7 | 2.0 | O=C1CC2(Cc3ccc(NC(=O)Cn4c(=O)n(-c5ccccn5)c5ccccc54)cc3C2)C(=O)N1 | 10.1016/j.bmcl.2008.10.106 | |||
| CHEMBL464263 | 184528 | 0 | None | - | 1 | Human | 7.0 | pKi | = | 7.0 | Binding | ChEMBL | 467 | 4 | 2 | 7 | 2.0 | O=C1CC2(Cc3ccc(NC(=O)Cn4c(=O)n(-c5ccccn5)c5ccccc54)cc3C2)C(=O)N1 | 10.1016/j.bmcl.2008.10.106 | |||
| 11261842 | 87838 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 591 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3ncccc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL215424 | 87838 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 591 | 4 | 2 | 5 | 4.4 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(N2Cc3ncccc3NC2=O)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 11215502 | 172914 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 594 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ccc(F)cc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| CHEMBL426142 | 172914 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 594 | 4 | 2 | 6 | 5.0 | O=C(N[C@@H]1N=C(c2ccccc2)c2ccccc2N(CC(F)(F)F)C1=O)N1CCC(n2c(O)nc3ccc(F)cc32)CC1 | 10.1016/j.bmcl.2006.07.044 | |||
| 23656588 | 98354 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 449 | 3 | 3 | 6 | 1.5 | O=C1NCC(c2cccnc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| CHEMBL240685 | 98354 | 0 | None | - | 1 | Human | 5.0 | pKi | = | 5 | Binding | ChEMBL | 449 | 3 | 3 | 6 | 1.5 | O=C1NCC(c2cccnc2)CC[C@H]1NC(=O)N1CCC(n2c(=O)[nH]c3ncccc32)CC1 | 10.1021/jm070668p | |||
| 68748835 | 224529 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 549 | 4 | 2 | 5 | 3.5 | C[C@@H]1[C@@H](C[C@H](NC(=O)C2=CN=C3C[C@]4(CC3=C2)C(=O)NC2=NC=CC=C42)C(=O)N1CC(F)(F)F)C1=CC=CC=C1 | None | |||
| 51049968 | 89335 | 47 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 534 | 3 | 2 | 7 | 4.5 | N[C@@H]1c2cccnc2[C@H](OC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)CC[C@H]1c1cccc(F)c1F | None | |||
| CHEMBL2178422 | 89335 | 47 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | Drug Central | 534 | 3 | 2 | 7 | 4.5 | N[C@@H]1c2cccnc2[C@H](OC(=O)N2CCC(n3c(=O)[nH]c4ncccc43)CC2)CC[C@H]1c1cccc(F)c1F | None | |||