Ligand source activities (1 row/activity)





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CHEMBL1893324 215839 24 None 1 3 Human 10.7 pEC50 = 10.7 Functional
Agonist activity at VPAC1 in human SH-SY5Y cells assessed as cAMP accumulation incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at VPAC1 in human SH-SY5Y cells assessed as cAMP accumulation incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O 10.1021/acs.jmedchem.0c01396
168299476 199525 0 None -1 3 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at VPAC1 in human SH-SY5Y cells assessed as cAMP accumulation incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at VPAC1 in human SH-SY5Y cells assessed as cAMP accumulation incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay
ChEMBL 4660 165 74 67 -19.8 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(N)=O)C(C)C)C(C)C)C(C)C)[C@@H](C)O 10.1021/acs.jmedchem.0c01396
CHEMBL5220770 199525 0 None -1 3 Human 10.5 pEC50 = 10.5 Functional
Agonist activity at VPAC1 in human SH-SY5Y cells assessed as cAMP accumulation incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at VPAC1 in human SH-SY5Y cells assessed as cAMP accumulation incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay
ChEMBL 4660 165 74 67 -19.8 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(N)=O)C(C)C)C(C)C)C(C)C)[C@@H](C)O 10.1021/acs.jmedchem.0c01396
CHEMBL4294827 220311 0 None -2 2 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CNC[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)NC(CC(N)=O)CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O nan
CHEMBL4280734 220188 0 None 223 2 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C nan
2263 7045 0 None -4 3 Human 9.2 pEC50 = 9.2 Functional
Activity at human VPAC1 receptor in CHO cells by measuring cAMP accumulationActivity at human VPAC1 receptor in CHO cells by measuring cAMP accumulation
ChEMBL None None None None 10.1021/jm0609059
44566111 7045 0 None -4 3 Human 9.2 pEC50 = 9.2 Functional
Activity at human VPAC1 receptor in CHO cells by measuring cAMP accumulationActivity at human VPAC1 receptor in CHO cells by measuring cAMP accumulation
ChEMBL None None None None 10.1021/jm0609059
CHEMBL219499 7045 0 None -4 3 Human 9.2 pEC50 = 9.2 Functional
Activity at human VPAC1 receptor in CHO cells by measuring cAMP accumulationActivity at human VPAC1 receptor in CHO cells by measuring cAMP accumulation
ChEMBL None None None None 10.1021/jm0609059
CHEMBL4295255 220314 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Induction of VIPR1 receptor internalization in CHOK1 cells expressing human VIPR1 by beta-galactosidase reporter gene assayInduction of VIPR1 receptor internalization in CHOK1 cells expressing human VIPR1 by beta-galactosidase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C nan
CHEMBL4282016 220207 0 None -204 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O nan
CHEMBL4277870 220160 0 None -1659 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C nan
CHEMBL4282364 220210 0 None -1071 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NC(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NC(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)CC(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C nan
CHEMBL4287451 220248 0 None -426 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NC(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(CCC(N)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C nan
CHEMBL4295255 220314 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C nan
CHEMBL4277441 220150 0 None -1202 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C nan
CHEMBL4286419 220242 0 None -234 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NC(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C nan
CHEMBL4281814 220203 0 None 58 2 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C nan
CHEMBL4290756 220280 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]1CCC[C@@H]1C(=O)NC(CC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)Cc1ccc(O)cc1)[C@@H](C)O nan
CHEMBL4277709 220156 0 None 870 2 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C nan
CHEMBL4277799 220159 0 None -977 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)NC(C)(C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C nan
CHEMBL4284839 220227 0 None 11 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)CC(CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C nan
CHEMBL4281905 220205 0 None -1 2 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C nan
CHEMBL4291903 220290 0 None -660 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]1CCC[C@@H]1C(=O)NC(CC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)CC(C)C)[C@@H](C)O)Cc1ccc(O)cc1)[C@@H](C)O nan
CHEMBL4282941 220213 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C nan
CHEMBL4294843 220312 0 None 11 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)NC(CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)CC(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C nan
CHEMBL4291119 220285 0 None -22 2 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(CCCCN)CC(=O)NCC(=O)NCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C nan
CHEMBL4277783 220158 0 None -1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)CC(NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CC(CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)C(C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C nan
CHEMBL4284961 220230 0 None -9 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR1 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H]1CNC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)CC(Cc1ccc(O)cc1)NC(=O)CC(CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O nan
57395756 77988 0 None - 1 Rat 7.0 pIC50 = 7 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 316 3 1 1 5.9 CC(C)c1cc(C(C)(C)C)cc(-c2cccc(Cl)c2)c1CO 10.1016/j.bmcl.2012.01.082
CHEMBL1956426 77988 0 None - 1 Rat 7.0 pIC50 = 7 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 316 3 1 1 5.9 CC(C)c1cc(C(C)(C)C)cc(-c2cccc(Cl)c2)c1CO 10.1016/j.bmcl.2012.01.082
57399212 77996 0 None - 1 Rat 5.0 pIC50 = 5.0 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 324 4 1 3 4.4 Cc1ccccc1CCC(=O)Nc1sc2c(c1C#N)CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL1956434 77996 0 None - 1 Rat 5.0 pIC50 = 5.0 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 324 4 1 3 4.4 Cc1ccccc1CCC(=O)Nc1sc2c(c1C#N)CCCC2 10.1016/j.bmcl.2012.01.082
11570626 9328 46 None -707 9 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at human VPAC1 expressed in HT-29 cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counterAntagonist activity at human VPAC1 expressed in HT-29 cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter
ChEMBL 587 9 2 5 7.5 COc1ccc2c(c1)ccc(c2)c1cc(nn1[C@H](c1ccc(cc1)C(=O)NCCC(=O)O)C)c1cc(Cl)cc(c1)Cl 10.1021/jm300579z
9135 9328 46 None -707 9 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at human VPAC1 expressed in HT-29 cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counterAntagonist activity at human VPAC1 expressed in HT-29 cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter
ChEMBL 587 9 2 5 7.5 COc1ccc2c(c1)ccc(c2)c1cc(nn1[C@H](c1ccc(cc1)C(=O)NCCC(=O)O)C)c1cc(Cl)cc(c1)Cl 10.1021/jm300579z
CHEMBL1933349 9328 46 None -707 9 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at human VPAC1 expressed in HT-29 cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counterAntagonist activity at human VPAC1 expressed in HT-29 cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter
ChEMBL 587 9 2 5 7.5 COc1ccc2c(c1)ccc(c2)c1cc(nn1[C@H](c1ccc(cc1)C(=O)NCCC(=O)O)C)c1cc(Cl)cc(c1)Cl 10.1021/jm300579z
DB12044 9328 46 None -707 9 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at human VPAC1 expressed in HT-29 cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counterAntagonist activity at human VPAC1 expressed in HT-29 cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter
ChEMBL 587 9 2 5 7.5 COc1ccc2c(c1)ccc(c2)c1cc(nn1[C@H](c1ccc(cc1)C(=O)NCCC(=O)O)C)c1cc(Cl)cc(c1)Cl 10.1021/jm300579z
168298339 199488 0 None -33 3 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at VPAC1 in human SH-SY5Y cells assessed as inhibition of PACAP38-induced cAMP accumulation pre-incubated for 30 mins followed by agonist addition and measured after 75 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAntagonist activity at VPAC1 in human SH-SY5Y cells assessed as inhibition of PACAP38-induced cAMP accumulation pre-incubated for 30 mins followed by agonist addition and measured after 75 mins by Eu-cAMP tracer based LANCE ultra cAMP assay
ChEMBL 4137 147 67 59 -16.2 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](CCS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C)C(C)C 10.1021/acs.jmedchem.0c01396
CHEMBL5219662 199488 0 None -33 3 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at VPAC1 in human SH-SY5Y cells assessed as inhibition of PACAP38-induced cAMP accumulation pre-incubated for 30 mins followed by agonist addition and measured after 75 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAntagonist activity at VPAC1 in human SH-SY5Y cells assessed as inhibition of PACAP38-induced cAMP accumulation pre-incubated for 30 mins followed by agonist addition and measured after 75 mins by Eu-cAMP tracer based LANCE ultra cAMP assay
ChEMBL 4137 147 67 59 -16.2 CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](CCS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C)C(C)C 10.1021/acs.jmedchem.0c01396
57395755 77987 0 None - 1 Rat 6.9 pIC50 = 6.9 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 332 3 1 1 6.4 CC(C)c1cc(C(C)(C)C)cc(-c2ccc3ccccc3c2)c1CO 10.1016/j.bmcl.2012.01.082
CHEMBL1956425 77987 0 None - 1 Rat 6.9 pIC50 = 6.9 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 332 3 1 1 6.4 CC(C)c1cc(C(C)(C)C)cc(-c2ccc3ccccc3c2)c1CO 10.1016/j.bmcl.2012.01.082
19220887 78001 2 None - 1 Rat 5.9 pIC50 = 5.9 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 344 4 1 3 4.7 N#Cc1c(NC(=O)CCc2ccc(Cl)cc2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL1956439 78001 2 None - 1 Rat 5.9 pIC50 = 5.9 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 344 4 1 3 4.7 N#Cc1c(NC(=O)CCc2ccc(Cl)cc2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
810647 77990 49 None - 1 Rat 4.9 pIC50 = 4.9 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 234 2 1 3 2.8 CCC(=O)Nc1sc2c(c1C#N)CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL1956428 77990 49 None - 1 Rat 4.9 pIC50 = 4.9 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 234 2 1 3 2.8 CCC(=O)Nc1sc2c(c1C#N)CCCC2 10.1016/j.bmcl.2012.01.082
57402730 78005 0 None - 1 Rat 4.9 pIC50 = 4.9 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 336 2 1 3 4.2 N#Cc1c(NC(=O)C2CCc3ccccc3C2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL1956443 78005 0 None - 1 Rat 4.9 pIC50 = 4.9 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 336 2 1 3 4.2 N#Cc1c(NC(=O)C2CCc3ccccc3C2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
57399163 77976 0 None - 1 Rat 5.9 pIC50 = 5.9 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 312 4 1 2 5.3 COc1ccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)cc1 10.1016/j.bmcl.2012.01.082
CHEMBL1956414 77976 0 None - 1 Rat 5.9 pIC50 = 5.9 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 312 4 1 2 5.3 COc1ccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)cc1 10.1016/j.bmcl.2012.01.082
290230 39384 37 None - 1 Rat 4.9 pIC50 = 4.9 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 220 1 1 3 2.5 CC(=O)Nc1sc2c(c1C#N)CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL1412798 39384 37 None - 1 Rat 4.9 pIC50 = 4.9 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 220 1 1 3 2.5 CC(=O)Nc1sc2c(c1C#N)CCCC2 10.1016/j.bmcl.2012.01.082
290221 94027 33 None - 1 Rat 4.8 pIC50 = 4.8 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 282 2 1 3 3.8 N#Cc1c(NC(=O)c2ccccc2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL233000 94027 33 None - 1 Rat 4.8 pIC50 = 4.8 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 282 2 1 3 3.8 N#Cc1c(NC(=O)c2ccccc2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
684674 159332 24 None - 1 Rat 5.8 pIC50 = 5.8 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 296 3 1 3 3.7 N#Cc1c(NC(=O)Cc2ccccc2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL397167 159332 24 None - 1 Rat 5.8 pIC50 = 5.8 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 296 3 1 3 3.7 N#Cc1c(NC(=O)Cc2ccccc2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
57402678 77975 0 None - 1 Rat 6.8 pIC50 = 6.8 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 328 4 1 2 6.0 CSc1cccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)c1 10.1016/j.bmcl.2012.01.082
CHEMBL1956413 77975 0 None - 1 Rat 6.8 pIC50 = 6.8 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 328 4 1 2 6.0 CSc1cccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)c1 10.1016/j.bmcl.2012.01.082
57399214 78006 0 None - 1 Rat 4.8 pIC50 = 4.8 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 322 2 1 3 3.9 N#Cc1c(NC(=O)C2Cc3ccccc3C2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL1956444 78006 0 None - 1 Rat 4.8 pIC50 = 4.8 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 322 2 1 3 3.9 N#Cc1c(NC(=O)C2Cc3ccccc3C2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
57399211 77986 0 None - 1 Rat 6.8 pIC50 = 6.8 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 332 3 1 1 6.4 CC(C)c1cc(C(C)(C)C)cc(-c2cccc3ccccc23)c1CO 10.1016/j.bmcl.2012.01.082
CHEMBL1956424 77986 0 None - 1 Rat 6.8 pIC50 = 6.8 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 332 3 1 1 6.4 CC(C)c1cc(C(C)(C)C)cc(-c2cccc3ccccc23)c1CO 10.1016/j.bmcl.2012.01.082
57390453 77993 1 None - 1 Rat 5.8 pIC50 = 5.8 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 260 2 1 3 3.2 N#Cc1c(NC(=O)C2CCC2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL1956431 77993 1 None - 1 Rat 5.8 pIC50 = 5.8 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 260 2 1 3 3.2 N#Cc1c(NC(=O)C2CCC2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
800118 77991 6 None - 1 Rat 5.7 pIC50 = 5.7 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 262 3 1 3 3.5 CC(C)CC(=O)Nc1sc2c(c1C#N)CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL1956429 77991 6 None - 1 Rat 5.7 pIC50 = 5.7 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 262 3 1 3 3.5 CC(C)CC(=O)Nc1sc2c(c1C#N)CCCC2 10.1016/j.bmcl.2012.01.082
57395758 78002 0 None - 1 Rat 5.7 pIC50 = 5.7 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 352 3 1 4 4.9 N#Cc1c(NC(=O)Cc2cc3ccccc3s2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL1956440 78002 0 None - 1 Rat 5.7 pIC50 = 5.7 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 352 3 1 4 4.9 N#Cc1c(NC(=O)Cc2cc3ccccc3s2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
57395679 77974 0 None - 1 Rat 6.7 pIC50 = 6.7 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 312 4 1 2 5.3 COc1cccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)c1 10.1016/j.bmcl.2012.01.082
CHEMBL1956412 77974 0 None - 1 Rat 6.7 pIC50 = 6.7 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 312 4 1 2 5.3 COc1cccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)c1 10.1016/j.bmcl.2012.01.082
57393989 77985 0 None - 1 Rat 6.7 pIC50 = 6.7 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 358 4 1 1 6.9 CC(C)c1cc(C(C)(C)C)cc(-c2cccc(-c3ccccc3)c2)c1CO 10.1016/j.bmcl.2012.01.082
CHEMBL1956423 77985 0 None - 1 Rat 6.7 pIC50 = 6.7 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 358 4 1 1 6.9 CC(C)c1cc(C(C)(C)C)cc(-c2cccc(-c3ccccc3)c2)c1CO 10.1016/j.bmcl.2012.01.082
57397531 77984 0 None - 1 Rat 6.6 pIC50 = 6.6 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 296 3 1 1 5.6 Cc1cccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)c1 10.1016/j.bmcl.2012.01.082
CHEMBL1956422 77984 0 None - 1 Rat 6.6 pIC50 = 6.6 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 296 3 1 1 5.6 Cc1cccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)c1 10.1016/j.bmcl.2012.01.082
694422 77992 30 None - 1 Rat 5.6 pIC50 = 5.6 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 246 2 1 3 2.8 N#Cc1c(NC(=O)C2CC2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL1956430 77992 30 None - 1 Rat 5.6 pIC50 = 5.6 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 246 2 1 3 2.8 N#Cc1c(NC(=O)C2CC2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
57399210 77983 0 None - 1 Rat 6.5 pIC50 = 6.5 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 316 3 1 1 5.9 CC(C)c1cc(C(C)(C)C)cc(-c2ccc(Cl)cc2)c1CO 10.1016/j.bmcl.2012.01.082
CHEMBL1956421 77983 0 None - 1 Rat 6.5 pIC50 = 6.5 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 316 3 1 1 5.9 CC(C)c1cc(C(C)(C)C)cc(-c2ccc(Cl)cc2)c1CO 10.1016/j.bmcl.2012.01.082
767327 77995 35 None - 1 Rat 6.5 pIC50 = 6.5 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 310 4 1 3 4.1 N#Cc1c(NC(=O)CCc2ccccc2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL1956433 77995 35 None - 1 Rat 6.5 pIC50 = 6.5 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 310 4 1 3 4.1 N#Cc1c(NC(=O)CCc2ccccc2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
57393988 77982 0 None - 1 Rat 6.5 pIC50 = 6.5 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 296 3 1 1 5.6 Cc1ccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)cc1 10.1016/j.bmcl.2012.01.082
CHEMBL1956420 77982 0 None - 1 Rat 6.5 pIC50 = 6.5 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 296 3 1 1 5.6 Cc1ccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)cc1 10.1016/j.bmcl.2012.01.082
57395754 77981 0 None - 1 Rat 6.5 pIC50 = 6.5 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 325 4 1 2 5.3 CC(C)c1cc(C(C)(C)C)cc(-c2cccc(N(C)C)c2)c1CO 10.1016/j.bmcl.2012.01.082
CHEMBL1956419 77981 0 None - 1 Rat 6.5 pIC50 = 6.5 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 325 4 1 2 5.3 CC(C)c1cc(C(C)(C)C)cc(-c2cccc(N(C)C)c2)c1CO 10.1016/j.bmcl.2012.01.082
57400888 77968 0 None - 1 Rat 5.5 pIC50 = 5.5 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 358 4 1 1 6.9 CC(C)c1cc(C(C)(C)C)cc(-c2ccccc2-c2ccccc2)c1CO 10.1016/j.bmcl.2012.01.082
CHEMBL1956259 77968 0 None - 1 Rat 5.5 pIC50 = 5.5 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 358 4 1 1 6.9 CC(C)c1cc(C(C)(C)C)cc(-c2ccccc2-c2ccccc2)c1CO 10.1016/j.bmcl.2012.01.082
729610 63209 12 None - 1 Rat 5.5 pIC50 = 5.5 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 248 2 1 3 3.1 CC(C)C(=O)Nc1sc2c(c1C#N)CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL1632048 63209 12 None - 1 Rat 5.5 pIC50 = 5.5 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 248 2 1 3 3.1 CC(C)C(=O)Nc1sc2c(c1C#N)CCCC2 10.1016/j.bmcl.2012.01.082
57400972 78003 0 None - 1 Rat 5.4 pIC50 = 5.4 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 338 3 1 4 3.8 N#Cc1c(NC(=O)CC2Cc3ccccc3O2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL1956441 78003 0 None - 1 Rat 5.4 pIC50 = 5.4 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 338 3 1 4 3.8 N#Cc1c(NC(=O)CC2Cc3ccccc3O2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
57397476 77980 0 None - 1 Rat 6.4 pIC50 = 6.4 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 282 3 1 1 5.3 CC(C)c1cc(C(C)(C)C)cc(-c2ccccc2)c1CO 10.1016/j.bmcl.2012.01.082
CHEMBL1956418 77980 0 None - 1 Rat 6.4 pIC50 = 6.4 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 282 3 1 1 5.3 CC(C)c1cc(C(C)(C)C)cc(-c2ccccc2)c1CO 10.1016/j.bmcl.2012.01.082
4625719 78000 12 None - 1 Rat 6.4 pIC50 = 6.4 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 340 5 1 4 4.1 COc1ccc(CCC(=O)Nc2sc3c(c2C#N)CCCC3)cc1 10.1016/j.bmcl.2012.01.082
CHEMBL1956438 78000 12 None - 1 Rat 6.4 pIC50 = 6.4 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 340 5 1 4 4.1 COc1ccc(CCC(=O)Nc2sc3c(c2C#N)CCCC3)cc1 10.1016/j.bmcl.2012.01.082
4578060 77994 10 None - 1 Rat 6.3 pIC50 = 6.3 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 274 2 1 3 3.6 N#Cc1c(NC(=O)C2CCCC2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL1956432 77994 10 None - 1 Rat 6.3 pIC50 = 6.3 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 274 2 1 3 3.6 N#Cc1c(NC(=O)C2CCCC2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
847353 158706 12 None - 1 Rat 6.3 pIC50 = 6.3 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 288 2 1 3 4.0 N#Cc1c(NC(=O)C2CCCCC2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL396627 158706 12 None - 1 Rat 6.3 pIC50 = 6.3 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 288 2 1 3 4.0 N#Cc1c(NC(=O)C2CCCCC2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
16644244 77998 8 None - 1 Rat 6.3 pIC50 = 6.3 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 324 4 1 3 4.4 Cc1ccc(CCC(=O)Nc2sc3c(c2C#N)CCCC3)cc1 10.1016/j.bmcl.2012.01.082
CHEMBL1956436 77998 8 None - 1 Rat 6.3 pIC50 = 6.3 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 324 4 1 3 4.4 Cc1ccc(CCC(=O)Nc2sc3c(c2C#N)CCCC3)cc1 10.1016/j.bmcl.2012.01.082
57393990 78004 0 None - 1 Rat 4.3 pIC50 = 4.3 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 335 3 2 3 4.2 N#Cc1c(NC(=O)Cc2cc3ccccc3[nH]2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL1956442 78004 0 None - 1 Rat 4.3 pIC50 = 4.3 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 335 3 2 3 4.2 N#Cc1c(NC(=O)Cc2cc3ccccc3[nH]2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
57392239 77999 0 None - 1 Rat 6.2 pIC50 = 6.2 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 340 5 1 4 4.1 COc1cccc(CCC(=O)Nc2sc3c(c2C#N)CCCC3)c1 10.1016/j.bmcl.2012.01.082
CHEMBL1956437 77999 0 None - 1 Rat 6.2 pIC50 = 6.2 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 340 5 1 4 4.1 COc1cccc(CCC(=O)Nc2sc3c(c2C#N)CCCC3)c1 10.1016/j.bmcl.2012.01.082
57390395 77979 0 None - 1 Rat 6.2 pIC50 = 6.2 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 358 4 1 1 6.9 CC(C)c1cc(C(C)(C)C)cc(-c2ccc(-c3ccccc3)cc2)c1CO 10.1016/j.bmcl.2012.01.082
CHEMBL1956417 77979 0 None - 1 Rat 6.2 pIC50 = 6.2 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 358 4 1 1 6.9 CC(C)c1cc(C(C)(C)C)cc(-c2ccc(-c3ccccc3)cc2)c1CO 10.1016/j.bmcl.2012.01.082
15015051 77978 0 None - 1 Rat 6.1 pIC50 = 6.1 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 300 3 1 1 5.4 CC(C)c1cc(C(C)(C)C)cc(-c2ccc(F)cc2)c1CO 10.1016/j.bmcl.2012.01.082
CHEMBL1956416 77978 0 None - 1 Rat 6.1 pIC50 = 6.1 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 300 3 1 1 5.4 CC(C)c1cc(C(C)(C)C)cc(-c2ccc(F)cc2)c1CO 10.1016/j.bmcl.2012.01.082
57399213 77997 1 None - 1 Rat 6.1 pIC50 = 6.1 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 324 4 1 3 4.4 Cc1cccc(CCC(=O)Nc2sc3c(c2C#N)CCCC3)c1 10.1016/j.bmcl.2012.01.082
CHEMBL1956435 77997 1 None - 1 Rat 6.1 pIC50 = 6.1 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 324 4 1 3 4.4 Cc1cccc(CCC(=O)Nc2sc3c(c2C#N)CCCC3)c1 10.1016/j.bmcl.2012.01.082
57395757 77989 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 310 3 1 1 5.9 Cc1ccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)cc1C 10.1016/j.bmcl.2012.01.082
CHEMBL1956427 77989 0 None - 1 Rat 7.1 pIC50 = 7.1 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 310 3 1 1 5.9 Cc1ccc(-c2cc(C(C)(C)C)cc(C(C)C)c2CO)cc1C 10.1016/j.bmcl.2012.01.082
57400906 77977 0 None - 1 Rat 6.1 pIC50 = 6.1 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 312 4 1 2 5.3 COc1ccccc1-c1cc(C(C)(C)C)cc(C(C)C)c1CO 10.1016/j.bmcl.2012.01.082
CHEMBL1956415 77977 0 None - 1 Rat 6.1 pIC50 = 6.1 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 312 4 1 2 5.3 COc1ccccc1-c1cc(C(C)(C)C)cc(C(C)C)c1CO 10.1016/j.bmcl.2012.01.082
775619 78007 16 None - 1 Rat 5.0 pIC50 = 5.0 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 312 4 1 4 3.5 N#Cc1c(NC(=O)COc2ccccc2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
CHEMBL1956445 78007 16 None - 1 Rat 5.0 pIC50 = 5.0 Functional
Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assayAntagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay
ChEMBL 312 4 1 4 3.5 N#Cc1c(NC(=O)COc2ccccc2)sc2c1CCCC2 10.1016/j.bmcl.2012.01.082
2258 9765 0 None -15 4 Human 7.4 pEC50 = 7.4 Functional
calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
2278 7116 0 None 4168 3 Human 7.6 pEC50 = 7.6 Functional
calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
16133238 9764 0 None -44 6 Human 7.6 pEC50 = 7.6 Functional
calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
2257 9764 0 None -44 6 Human 7.6 pEC50 = 7.6 Functional
calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
44134520 9764 0 None -44 6 Human 7.6 pEC50 = 7.6 Functional
calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
1152 10767 16 None 1 8 Human 7.9 pEC50 = 7.9 Functional
calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
16129679 10767 16 None 1 8 Human 7.9 pEC50 = 7.9 Functional
calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
53395115 10767 16 None 1 8 Human 7.9 pEC50 = 7.9 Functional
calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
91898389 10767 16 None 1 8 Human 7.9 pEC50 = 7.9 Functional
calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
CHEMBL1981592 10767 16 None 1 8 Human 7.9 pEC50 = 7.9 Functional
calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
1152 10767 16 None 1 8 Human 10.0 pEC50 = 10 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
16129679 10767 16 None 1 8 Human 10.0 pEC50 = 10 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
53395115 10767 16 None 1 8 Human 10.0 pEC50 = 10 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
91898389 10767 16 None 1 8 Human 10.0 pEC50 = 10 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
CHEMBL1981592 10767 16 None 1 8 Human 10.0 pEC50 = 10 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
2278 7116 0 None 4168 3 Human 10.2 pEC50 = 10.2 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
2259 10119 0 None -190 4 Human 6.0 pEC50 = 6 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 10570056
129887154 7370 0 None -177 3 Human 7.0 pEC50 = 7 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 11978642
155817438 7370 0 None -177 3 Human 7.0 pEC50 = 7 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 11978642
16214732 7370 0 None -177 3 Human 7.0 pEC50 = 7 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 11978642
2269 7370 0 None -177 3 Human 7.0 pEC50 = 7 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 11978642
2281 7370 0 None -177 3 Human 7.0 pEC50 = 7 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 11978642
2272 9852 0 None -30 3 Human 8.1 pEC50 = 8.1 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
1152 10767 16 None 1 8 Human 9.3 pEC50 = 9.3 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 10570056
16129679 10767 16 None 1 8 Human 9.3 pEC50 = 9.3 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 10570056
53395115 10767 16 None 1 8 Human 9.3 pEC50 = 9.3 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 10570056
91898389 10767 16 None 1 8 Human 9.3 pEC50 = 9.3 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 10570056
CHEMBL1981592 10767 16 None 1 8 Human 9.3 pEC50 = 9.3 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 10570056
2258 9765 0 None -15 4 Human 9.7 pEC50 = 9.7 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
16133238 9764 0 None -44 6 Human 9.9 pEC50 = 9.9 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
2257 9764 0 None -44 6 Human 9.9 pEC50 = 9.9 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
44134520 9764 0 None -44 6 Human 9.9 pEC50 = 9.9 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
16133238 9764 0 None -44 6 Human 8.2 pEC50 = 8.2 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
2257 9764 0 None -44 6 Human 8.2 pEC50 = 8.2 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
44134520 9764 0 None -44 6 Human 8.2 pEC50 = 8.2 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
3842 9214 0 None -2 5 Human 8.3 pEC50 = 8.3 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
1152 10767 16 None 1 8 Human 8.5 pEC50 = 8.5 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
16129679 10767 16 None 1 8 Human 8.5 pEC50 = 8.5 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
53395115 10767 16 None 1 8 Human 8.5 pEC50 = 8.5 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
91898389 10767 16 None 1 8 Human 8.5 pEC50 = 8.5 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
CHEMBL1981592 10767 16 None 1 8 Human 8.5 pEC50 = 8.5 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
1152 10767 16 None 1 8 Human 8.9 pEC50 = 8.9 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9152366
16129679 10767 16 None 1 8 Human 8.9 pEC50 = 8.9 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9152366
53395115 10767 16 None 1 8 Human 8.9 pEC50 = 8.9 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9152366
91898389 10767 16 None 1 8 Human 8.9 pEC50 = 8.9 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9152366
CHEMBL1981592 10767 16 None 1 8 Human 8.9 pEC50 = 8.9 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9152366
2278 7116 0 None 4168 3 Human 9.4 pEC50 = 9.4 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 10801840
1152 10767 16 None 1 8 Human 9.4 pEC50 = 9.4 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 10801840
16129679 10767 16 None 1 8 Human 9.4 pEC50 = 9.4 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 10801840
53395115 10767 16 None 1 8 Human 9.4 pEC50 = 9.4 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 10801840
91898389 10767 16 None 1 8 Human 9.4 pEC50 = 9.4 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 10801840
CHEMBL1981592 10767 16 None 1 8 Human 9.4 pEC50 = 9.4 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 10801840
2272 9852 0 None -30 3 Human 5.5 pEC50 > 5.5 Functional
calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
2276 10118 0 None -316 2 Human 6.0 pEC50 > 6 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9152366
2259 10119 0 None -190 4 Human 6.0 pEC50 > 6 Functional
stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
43708 224482 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
NoneNone
Drug Central 525 10 3 13 -0.7 CN(C)CCN1N=NN=C1SCC1=C(N2[C@H](SC1)[C@H](NC(=O)CC1=CSC(N)=N1)C2=O)C(O)=O None
131850923 9851 0 None -1 5 Human 8.7 pIC50 = 8.7 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 10570056
155817437 9851 0 None -1 5 Human 8.7 pIC50 = 8.7 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 10570056
16154651 9851 0 None -1 5 Human 8.7 pIC50 = 8.7 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 10570056
2268 9851 0 None -1 5 Human 8.7 pIC50 = 8.7 Functional
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 10570056
131850923 9851 0 None -1 5 Human 8.0 pIC50 = 8 Functional
inhibition of calcium influx stimulated by 30nM VIP in CHO cells stably expressing recombinant receptorinhibition of calcium influx stimulated by 30nM VIP in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
155817437 9851 0 None -1 5 Human 8.0 pIC50 = 8 Functional
inhibition of calcium influx stimulated by 30nM VIP in CHO cells stably expressing recombinant receptorinhibition of calcium influx stimulated by 30nM VIP in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
16154651 9851 0 None -1 5 Human 8.0 pIC50 = 8 Functional
inhibition of calcium influx stimulated by 30nM VIP in CHO cells stably expressing recombinant receptorinhibition of calcium influx stimulated by 30nM VIP in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
2268 9851 0 None -1 5 Human 8.0 pIC50 = 8 Functional
inhibition of calcium influx stimulated by 30nM VIP in CHO cells stably expressing recombinant receptorinhibition of calcium influx stimulated by 30nM VIP in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
131850923 9851 0 None -1 5 Human 7.1 pIC50 = 7.1 Functional
inhibition of cyclic AMP formation stimulated by 0.3nM VIP in CHO cells stably expressing recombinant receptorinhibition of cyclic AMP formation stimulated by 0.3nM VIP in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
155817437 9851 0 None -1 5 Human 7.1 pIC50 = 7.1 Functional
inhibition of cyclic AMP formation stimulated by 0.3nM VIP in CHO cells stably expressing recombinant receptorinhibition of cyclic AMP formation stimulated by 0.3nM VIP in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
16154651 9851 0 None -1 5 Human 7.1 pIC50 = 7.1 Functional
inhibition of cyclic AMP formation stimulated by 0.3nM VIP in CHO cells stably expressing recombinant receptorinhibition of cyclic AMP formation stimulated by 0.3nM VIP in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633
2268 9851 0 None -1 5 Human 7.1 pIC50 = 7.1 Functional
inhibition of cyclic AMP formation stimulated by 0.3nM VIP in CHO cells stably expressing recombinant receptorinhibition of cyclic AMP formation stimulated by 0.3nM VIP in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 16930633




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DOI

CHEMBL524658 222393 0 None - 1 Human 10.4 pIC50 = 10.4 Binding
Displacement of [125I]PACAP1-27 from human recombinant PAC1 receptor expressed in CHO cells measured after 120 mins by scintillation counting methodDisplacement of [125I]PACAP1-27 from human recombinant PAC1 receptor expressed in CHO cells measured after 120 mins by scintillation counting method
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(N)=O)C(C)C)C(C)C)C(C)C)[C@@H](C)O 10.1016/j.bmc.2016.11.014
CHEMBL524658 222393 0 None - 1 Human 10.3 pIC50 = 10.3 Binding
Binding affinity to human VPAC1 receptor by radioligand displacement assayBinding affinity to human VPAC1 receptor by radioligand displacement assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(N)=O)C(C)C)C(C)C)C(C)C)[C@@H](C)O 10.1016/j.bmc.2013.03.016
CHEMBL1893324 215839 24 None - 1 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]VIP from human recombinant VIP1 receptor expressed in CHO cellsDisplacement of [125I]VIP from human recombinant VIP1 receptor expressed in CHO cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O 10.1016/j.bmc.2016.03.006
CHEMBL3884667 219196 0 None - 0 Human 10.0 pIC50 = 10.0 Binding
Displacement of [125I]VIP from human recombinant VPAC1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]VIP from human recombinant VPAC1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O 10.1016/j.bmc.2016.11.014
CHEMBL1893324 215839 24 None - 1 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to human VPAC1 receptor by radioligand displacement assayBinding affinity to human VPAC1 receptor by radioligand displacement assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O 10.1016/j.bmc.2013.03.016
CHEMBL1893324 215839 24 None - 1 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to human VPAC1 receptor by radioligand displacement assayBinding affinity to human VPAC1 receptor by radioligand displacement assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O 10.1016/j.ejmech.2013.01.044
72548703 168346 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]VIP from human recombinant VPAC1 receptor after 60 mins by scintillation counting analysisDisplacement of [125I]VIP from human recombinant VPAC1 receptor after 60 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
CHEMBL4128926 168346 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]VIP from human recombinant VPAC1 receptor after 60 mins by scintillation counting analysisDisplacement of [125I]VIP from human recombinant VPAC1 receptor after 60 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
127034614 143281 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysis
ChEMBL 3246 105 48 45 -10.8 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccccc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O 10.1016/j.ejmech.2015.09.017
CHEMBL3736230 143281 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysis
ChEMBL 3246 105 48 45 -10.8 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccccc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O 10.1016/j.ejmech.2015.09.017
127034614 143281 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysis
ChEMBL 3246 105 48 45 -10.8 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccccc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O 10.1016/j.ejmech.2015.09.017
CHEMBL3736230 143281 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysis
ChEMBL 3246 105 48 45 -10.8 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccccc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O 10.1016/j.ejmech.2015.09.017
2263 7045 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]PACAP27 from human VPAC1 receptor expressed in CHO cellsDisplacement of [125I]PACAP27 from human VPAC1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm0609059
44566111 7045 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]PACAP27 from human VPAC1 receptor expressed in CHO cellsDisplacement of [125I]PACAP27 from human VPAC1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm0609059
CHEMBL219499 7045 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125I]PACAP27 from human VPAC1 receptor expressed in CHO cellsDisplacement of [125I]PACAP27 from human VPAC1 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/jm0609059
CHEMBL507480 221114 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysis
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O 10.1016/j.ejmech.2015.09.017
CHEMBL4296687 220320 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of human VIP1 receptorInhibition of human VIP1 receptor
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)O 10.1021/jm701575k
CHEMBL524852 222400 6 None - 0 Human 8.2 pIC50 = 8.2 Binding
Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysis
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O 10.1016/j.ejmech.2015.09.017
127035881 143263 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysis
ChEMBL 3264 105 48 45 -10.6 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccc(F)cc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O 10.1016/j.ejmech.2015.09.017
CHEMBL3736134 143263 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysis
ChEMBL 3264 105 48 45 -10.6 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccc(F)cc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O 10.1016/j.ejmech.2015.09.017
127035881 143263 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysis
ChEMBL 3264 105 48 45 -10.6 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccc(F)cc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O 10.1016/j.ejmech.2015.09.017
CHEMBL3736134 143263 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC1 expressed in CHO cells after 90 mins by gamma counting analysis
ChEMBL 3264 105 48 45 -10.6 CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccc(F)cc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O 10.1016/j.ejmech.2015.09.017
CHEMBL1893324 215839 24 None - 1 Human 10.2 pKi = 10.2 Binding
Binding affinity to human VPAC1 receptor by radioligand displacement assayBinding affinity to human VPAC1 receptor by radioligand displacement assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O 10.1016/j.ejmech.2013.01.044
1155 10345 0 None - 2 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
16129665 10345 0 None - 2 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
3643 10345 0 None - 2 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
CHEMBL1201488 10345 0 None - 2 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
DB00021 10345 0 None - 2 Rat 6.5 pIC50 = 6.5 Binding
Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
3842 9214 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
1152 10767 16 None - 4 Rat 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
16129679 10767 16 None - 4 Rat 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
53395115 10767 16 None - 4 Rat 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
91898389 10767 16 None - 4 Rat 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
CHEMBL1981592 10767 16 None - 4 Rat 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
3293 7256 0 None - 0 Rat 9.0 pIC50 = 9 Binding
Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
1155 10345 0 None -3162 2 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
16129665 10345 0 None -3162 2 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
3643 10345 0 None -3162 2 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
CHEMBL1201488 10345 0 None -3162 2 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
DB00021 10345 0 None -3162 2 Human 5.8 pIC50 = 5.8 Binding
Inhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
3293 7256 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Inhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
1152 10767 16 None 5 4 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
16129679 10767 16 None 5 4 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
53395115 10767 16 None 5 4 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
91898389 10767 16 None 5 4 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
CHEMBL1981592 10767 16 None 5 4 Human 8.7 pIC50 = 8.7 Binding
Inhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
3842 9214 0 None - 0 Human 9.0 pIC50 = 9 Binding
Inhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from LoVo cells expressing recombinant receptor
Guide to Pharmacology None None None None 9437714
129887154 7370 0 None - 1 Human 5.1 pIC50 = 5.1 Binding
inhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11978642
155817438 7370 0 None - 1 Human 5.1 pIC50 = 5.1 Binding
inhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11978642
16214732 7370 0 None - 1 Human 5.1 pIC50 = 5.1 Binding
inhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11978642
2269 7370 0 None - 1 Human 5.1 pIC50 = 5.1 Binding
inhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11978642
2281 7370 0 None - 1 Human 5.1 pIC50 = 5.1 Binding
inhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11978642
2275 9888 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
1155 10345 0 None -3162 2 Human 5.8 pIC50 = 5.8 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
16129665 10345 0 None -3162 2 Human 5.8 pIC50 = 5.8 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
3643 10345 0 None -3162 2 Human 5.8 pIC50 = 5.8 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
CHEMBL1201488 10345 0 None -3162 2 Human 5.8 pIC50 = 5.8 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
DB00021 10345 0 None -3162 2 Human 5.8 pIC50 = 5.8 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
16132369 8699 0 None - 1 Human 6.0 pIC50 = 6 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
2280 8699 0 None - 1 Human 6.0 pIC50 = 6 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
53230038 8699 0 None - 1 Human 6.0 pIC50 = 6 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
2273 9883 0 None - 0 Human 6.0 pIC50 = 6 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
2259 10119 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 10570056
1155 10345 0 None - 2 Rat 6.5 pIC50 = 6.5 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
16129665 10345 0 None - 2 Rat 6.5 pIC50 = 6.5 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
3643 10345 0 None - 2 Rat 6.5 pIC50 = 6.5 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
CHEMBL1201488 10345 0 None - 2 Rat 6.5 pIC50 = 6.5 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
DB00021 10345 0 None - 2 Rat 6.5 pIC50 = 6.5 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
2272 9852 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11068102
2259 10119 0 None - 0 Human 7.0 pIC50 = 7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9145428
2266 9669 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
3842 9214 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
16133238 9764 0 None 1 3 Human 7.8 pIC50 = 7.8 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
2257 9764 0 None 1 3 Human 7.8 pIC50 = 7.8 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
44134520 9764 0 None 1 3 Human 7.8 pIC50 = 7.8 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
131850923 9851 0 None - 0 Rat 8.0 pIC50 = 8 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9437716
155817437 9851 0 None - 0 Rat 8.0 pIC50 = 8 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9437716
16154651 9851 0 None - 0 Rat 8.0 pIC50 = 8 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9437716
2268 9851 0 None - 0 Rat 8.0 pIC50 = 8 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9437716
1152 10767 16 None 5 4 Human 8.0 pIC50 = 8 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
16129679 10767 16 None 5 4 Human 8.0 pIC50 = 8 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
53395115 10767 16 None 5 4 Human 8.0 pIC50 = 8 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
91898389 10767 16 None 5 4 Human 8.0 pIC50 = 8 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
CHEMBL1981592 10767 16 None 5 4 Human 8.0 pIC50 = 8 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
16132369 8699 0 None - 1 Rat 8.1 pIC50 = 8.1 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
2280 8699 0 None - 1 Rat 8.1 pIC50 = 8.1 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
53230038 8699 0 None - 1 Rat 8.1 pIC50 = 8.1 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
2271 9670 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9726637
16133238 9764 0 None 1 3 Human 8.5 pIC50 = 8.5 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
2257 9764 0 None 1 3 Human 8.5 pIC50 = 8.5 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
44134520 9764 0 None 1 3 Human 8.5 pIC50 = 8.5 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
2273 9883 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
2275 9888 0 None - 0 Rat 8.5 pIC50 = 8.5 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
2271 9670 0 None - 0 Rat 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9726637
1152 10767 16 None 5 4 Human 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9726637
1152 10767 16 None 5 4 Human 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
1152 10767 16 None - 4 Rat 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9726637
16129679 10767 16 None 5 4 Human 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9726637
16129679 10767 16 None 5 4 Human 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
16129679 10767 16 None - 4 Rat 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9726637
53395115 10767 16 None 5 4 Human 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9726637
53395115 10767 16 None 5 4 Human 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
53395115 10767 16 None - 4 Rat 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9726637
91898389 10767 16 None 5 4 Human 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9726637
91898389 10767 16 None 5 4 Human 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
91898389 10767 16 None - 4 Rat 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9726637
CHEMBL1981592 10767 16 None 5 4 Human 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9726637
CHEMBL1981592 10767 16 None 5 4 Human 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
CHEMBL1981592 10767 16 None - 4 Rat 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9726637
16133238 9764 0 None - 3 Rat 9.0 pIC50 = 9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
2257 9764 0 None - 3 Rat 9.0 pIC50 = 9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
44134520 9764 0 None - 3 Rat 9.0 pIC50 = 9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
1152 10767 16 None - 4 Rat 9.0 pIC50 = 9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
16129679 10767 16 None - 4 Rat 9.0 pIC50 = 9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
53395115 10767 16 None - 4 Rat 9.0 pIC50 = 9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
91898389 10767 16 None - 4 Rat 9.0 pIC50 = 9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
CHEMBL1981592 10767 16 None - 4 Rat 9.0 pIC50 = 9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9928018
1152 10767 16 None 5 4 Human 9.3 pIC50 = 9.3 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 10570056
16129679 10767 16 None 5 4 Human 9.3 pIC50 = 9.3 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 10570056
53395115 10767 16 None 5 4 Human 9.3 pIC50 = 9.3 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 10570056
91898389 10767 16 None 5 4 Human 9.3 pIC50 = 9.3 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 10570056
CHEMBL1981592 10767 16 None 5 4 Human 9.3 pIC50 = 9.3 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 10570056
131850923 9851 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor, or from LoVo cells which endogenously express the receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor, or from LoVo cells which endogenously express the receptor
Guide to Pharmacology None None None None 10570056
131850923 9851 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor, or from LoVo cells which endogenously express the receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor, or from LoVo cells which endogenously express the receptor
Guide to Pharmacology None None None None 9437716
155817437 9851 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor, or from LoVo cells which endogenously express the receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor, or from LoVo cells which endogenously express the receptor
Guide to Pharmacology None None None None 10570056
155817437 9851 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor, or from LoVo cells which endogenously express the receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor, or from LoVo cells which endogenously express the receptor
Guide to Pharmacology None None None None 9437716
16154651 9851 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor, or from LoVo cells which endogenously express the receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor, or from LoVo cells which endogenously express the receptor
Guide to Pharmacology None None None None 10570056
16154651 9851 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor, or from LoVo cells which endogenously express the receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor, or from LoVo cells which endogenously express the receptor
Guide to Pharmacology None None None None 9437716
2268 9851 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor, or from LoVo cells which endogenously express the receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor, or from LoVo cells which endogenously express the receptor
Guide to Pharmacology None None None None 10570056
2268 9851 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor, or from LoVo cells which endogenously express the receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor, or from LoVo cells which endogenously express the receptor
Guide to Pharmacology None None None None 9437716
2259 10119 0 None - 0 Human 6.0 pIC50 > 6 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 11931347
53314964 223100 0 125I-VIP 1 3 Human 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 3325 113 51 48 -14.6 CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N None
53314964 223100 0 125I-VIP 1 3 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 3325 113 51 48 -14.6 CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N None
53314964 223100 0 125I-VIP 1 3 Human 8.8 pKi = 8.8 Binding
NoneNone
PDSP KiDatabase 3325 113 51 48 -14.6 CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N None
243 9976 91 125I-VIP -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3052762 9976 91 125I-VIP -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
3502 9976 91 125I-VIP -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
CHEMBL117287 9976 91 125I-VIP -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
DB06480 9976 91 125I-VIP -1096 34 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 367 6 2 5 2.1 COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N None
1152 10767 16 None 5 4 Human 9.7 pKi = 9.7 Binding
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 8074647
16129679 10767 16 None 5 4 Human 9.7 pKi = 9.7 Binding
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 8074647
53395115 10767 16 None 5 4 Human 9.7 pKi = 9.7 Binding
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 8074647
91898389 10767 16 None 5 4 Human 9.7 pKi = 9.7 Binding
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 8074647
CHEMBL1981592 10767 16 None 5 4 Human 9.7 pKi = 9.7 Binding
cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 8074647
1152 10767 16 None 5 4 Human 9.7 pKi = 9.7 Binding
cyclic AMP formation in HEK293 cells stably expressing recombinant receptorcyclic AMP formation in HEK293 cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 8074647
16129679 10767 16 None 5 4 Human 9.7 pKi = 9.7 Binding
cyclic AMP formation in HEK293 cells stably expressing recombinant receptorcyclic AMP formation in HEK293 cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 8074647
53395115 10767 16 None 5 4 Human 9.7 pKi = 9.7 Binding
cyclic AMP formation in HEK293 cells stably expressing recombinant receptorcyclic AMP formation in HEK293 cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 8074647
91898389 10767 16 None 5 4 Human 9.7 pKi = 9.7 Binding
cyclic AMP formation in HEK293 cells stably expressing recombinant receptorcyclic AMP formation in HEK293 cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 8074647
CHEMBL1981592 10767 16 None 5 4 Human 9.7 pKi = 9.7 Binding
cyclic AMP formation in HEK293 cells stably expressing recombinant receptorcyclic AMP formation in HEK293 cells stably expressing recombinant receptor
Guide to Pharmacology None None None None 8074647
1152 10767 16 None 5 4 Human 8.5 pKi = 8.5 Binding
inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9152366
16129679 10767 16 None 5 4 Human 8.5 pKi = 8.5 Binding
inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9152366
53395115 10767 16 None 5 4 Human 8.5 pKi = 8.5 Binding
inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9152366
91898389 10767 16 None 5 4 Human 8.5 pKi = 8.5 Binding
inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9152366
CHEMBL1981592 10767 16 None 5 4 Human 8.5 pKi = 8.5 Binding
inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9152366
2274 9885 0 None - 1 Human 5.7 pKi = 5.7 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
16132353 8570 0 None - 1 Human 6.2 pKi = 6.2 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
2270 8570 0 None - 1 Human 6.2 pKi = 6.2 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
16132369 8699 0 None - 1 Human 7.3 pKi = 7.3 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
2280 8699 0 None - 1 Human 7.3 pKi = 7.3 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
53230038 8699 0 None - 1 Human 7.3 pKi = 7.3 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
2278 7116 0 None 316 2 Human 8.1 pKi = 8.1 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 10801840
2258 9765 0 None -2 3 Human 8.2 pKi = 8.2 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
16133238 9764 0 None 1 3 Human 8.9 pKi = 8.9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
2257 9764 0 None 1 3 Human 8.9 pKi = 8.9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
44134520 9764 0 None 1 3 Human 8.9 pKi = 8.9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
1152 10767 16 None 5 4 Human 9.0 pKi = 9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 10801840
1152 10767 16 None 5 4 Human 9.0 pKi = 9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
16129679 10767 16 None 5 4 Human 9.0 pKi = 9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 10801840
16129679 10767 16 None 5 4 Human 9.0 pKi = 9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
53395115 10767 16 None 5 4 Human 9.0 pKi = 9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 10801840
53395115 10767 16 None 5 4 Human 9.0 pKi = 9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
91898389 10767 16 None 5 4 Human 9.0 pKi = 9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 10801840
91898389 10767 16 None 5 4 Human 9.0 pKi = 9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
CHEMBL1981592 10767 16 None 5 4 Human 9.0 pKi = 9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 10801840
CHEMBL1981592 10767 16 None 5 4 Human 9.0 pKi = 9 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
1152 10767 16 None 5 4 Human 9.1 pKi = 9.1 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8074647
16129679 10767 16 None 5 4 Human 9.1 pKi = 9.1 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8074647
53395115 10767 16 None 5 4 Human 9.1 pKi = 9.1 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8074647
91898389 10767 16 None 5 4 Human 9.1 pKi = 9.1 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8074647
CHEMBL1981592 10767 16 None 5 4 Human 9.1 pKi = 9.1 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8074647
1152 10767 16 None 5 4 Human 8.9 pKi = 8.9 Binding
inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor
Guide to Pharmacology None None None None 9454823
16129679 10767 16 None 5 4 Human 8.9 pKi = 8.9 Binding
inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor
Guide to Pharmacology None None None None 9454823
53395115 10767 16 None 5 4 Human 8.9 pKi = 8.9 Binding
inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor
Guide to Pharmacology None None None None 9454823
91898389 10767 16 None 5 4 Human 8.9 pKi = 8.9 Binding
inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor
Guide to Pharmacology None None None None 9454823
CHEMBL1981592 10767 16 None 5 4 Human 8.9 pKi = 8.9 Binding
inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor
Guide to Pharmacology None None None None 9454823
1152 10767 16 None 5 4 Human 9.1 pKi = 9.1 Binding
inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor
Guide to Pharmacology None None None None 8390245
16129679 10767 16 None 5 4 Human 9.1 pKi = 9.1 Binding
inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor
Guide to Pharmacology None None None None 8390245
53395115 10767 16 None 5 4 Human 9.1 pKi = 9.1 Binding
inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor
Guide to Pharmacology None None None None 8390245
91898389 10767 16 None 5 4 Human 9.1 pKi = 9.1 Binding
inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor
Guide to Pharmacology None None None None 8390245
CHEMBL1981592 10767 16 None 5 4 Human 9.1 pKi = 9.1 Binding
inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor
Guide to Pharmacology None None None None 8390245
1152 10767 16 None 5 4 Human 9.8 pKi = 9.8 Binding
inhibition of [125I]-VIP binding to membranes from HEK293 cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from HEK293 cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8074647
16129679 10767 16 None 5 4 Human 9.8 pKi = 9.8 Binding
inhibition of [125I]-VIP binding to membranes from HEK293 cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from HEK293 cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8074647
53395115 10767 16 None 5 4 Human 9.8 pKi = 9.8 Binding
inhibition of [125I]-VIP binding to membranes from HEK293 cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from HEK293 cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8074647
91898389 10767 16 None 5 4 Human 9.8 pKi = 9.8 Binding
inhibition of [125I]-VIP binding to membranes from HEK293 cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from HEK293 cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8074647
CHEMBL1981592 10767 16 None 5 4 Human 9.8 pKi = 9.8 Binding
inhibition of [125I]-VIP binding to membranes from HEK293 cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from HEK293 cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8074647
2276 10118 0 None -316 2 Human 5.5 pKi > 5.5 Binding
inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 9152366
1155 10345 0 None -3162 2 Human 5.0 pKi > 5 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
16129665 10345 0 None -3162 2 Human 5.0 pKi > 5 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
3643 10345 0 None -3162 2 Human 5.0 pKi > 5 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
CHEMBL1201488 10345 0 None -3162 2 Human 5.0 pKi > 5 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009
DB00021 10345 0 None -3162 2 Human 5.0 pKi > 5 Binding
inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor
Guide to Pharmacology None None None None 8791009