Biased Signaling Atlas

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	CHEMBL3102930	217817	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@]1(C)CCCC/C=C\CCCC[C@](C)(NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O	10.1021/ml400257h
	168299476	199525	0	None	-1	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at VPAC2 in human SH-SY5Y cells assessed as cAMP accumulation incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at VPAC2 in human SH-SY5Y cells assessed as cAMP accumulation incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	4660	165	74	67	-19.8	CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(N)=O)C(C)C)C(C)C)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.0c01396
	CHEMBL5220770	199525	0	None	-1	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at VPAC2 in human SH-SY5Y cells assessed as cAMP accumulation incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at VPAC2 in human SH-SY5Y cells assessed as cAMP accumulation incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	4660	165	74	67	-19.8	CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(N)=O)C(C)C)C(C)C)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.0c01396
	CHEMBL4294827	220311	0	None	2	2	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CNC[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)NC(CC(N)=O)CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O	nan
	CHEMBL1893324	215839	24	None	-1	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at VPAC2 in human SH-SY5Y cells assessed as cAMP accumulation incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAgonist activity at VPAC2 in human SH-SY5Y cells assessed as cAMP accumulation incubated for 60 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O	10.1021/acs.jmedchem.0c01396
	2263	7045	0	None	-1	3	Human	10.1	pEC50	=	10.1	Functional	Activity at human VPAC2 receptor in CHO cells by measuring cAMP accumulationActivity at human VPAC2 receptor in CHO cells by measuring cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm0609059
	44566111	7045	0	None	-1	3	Human	10.1	pEC50	=	10.1	Functional	Activity at human VPAC2 receptor in CHO cells by measuring cAMP accumulationActivity at human VPAC2 receptor in CHO cells by measuring cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm0609059
	CHEMBL219499	7045	0	None	-1	3	Human	10.1	pEC50	=	10.1	Functional	Activity at human VPAC2 receptor in CHO cells by measuring cAMP accumulationActivity at human VPAC2 receptor in CHO cells by measuring cAMP accumulation	ChEMBL		None	None	None		None	10.1021/jm0609059
	CHEMBL3102924	217811	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O	10.1021/ml400257h
	CHEMBL3102925	217812	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)CC)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(C)C	10.1021/ml400257h
	CHEMBL3102919	217806	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		None	10.1021/ml400257h
	CHEMBL4277441	220150	0	None	1202	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C	nan
	1152	10767	16	None	-3	8	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		None	10.1021/ml400257h
	16129679	10767	16	None	-3	8	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		None	10.1021/ml400257h
	53395115	10767	16	None	-3	8	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		None	10.1021/ml400257h
	91898389	10767	16	None	-3	8	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		None	10.1021/ml400257h
	CHEMBL1981592	10767	16	None	-3	8	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		None	10.1021/ml400257h
	CHEMBL3102922	217809	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		None	10.1021/ml400257h
	CHEMBL3102929	217816	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		C=CCCC[C@](C)(NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@](C)(CCCC=C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)C(C)C)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O	10.1021/ml400257h
	CHEMBL3102931	217818	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@]1(C)CCCC/C=C\CCCC[C@](C)(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O	10.1021/ml400257h
	CHEMBL3102921	217808	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		None	10.1021/ml400257h
	CHEMBL3105020	217850	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@]1(C)CCCC/C=C\CCCC[C@@](C)(C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC1=O)C(C)C	10.1021/ml400257h
	CHEMBL4291119	220285	0	None	22	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(CCCCN)CC(=O)NCC(=O)NCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C	nan
	CHEMBL4277799	220159	0	None	977	2	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)NC(C)(C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C	nan
	CHEMBL4285873	220238	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C	nan
	CHEMBL440082	220639	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Activity at human VPAC2 receptor in CHO cells by measuring cAMP accumulationActivity at human VPAC2 receptor in CHO cells by measuring cAMP accumulation	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)O	10.1021/jm0609059
	CHEMBL4282016	220207	0	None	204	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O	nan
	CHEMBL4281547	220200	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)NC(C)(C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C	nan
	CHEMBL4277870	220160	0	None	1659	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C	nan
	CHEMBL4294951	220313	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C	nan
	CHEMBL4289726	220266	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]1CCC[C@@H]1C(=O)NC(CC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NCCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)Cc1ccc(O)cc1)[C@@H](C)O	nan
	CHEMBL3102923	217810	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCCNC(=O)CC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2cnc[nH]2)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O	10.1021/ml400257h
	CHEMBL4291903	220290	0	None	660	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]1CCC[C@@H]1C(=O)NC(CC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)CC(C)C)[C@@H](C)O)Cc1ccc(O)cc1)[C@@H](C)O	nan
	CHEMBL4276843	220146	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NC(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(CC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)CC(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C	nan
	CHEMBL4286419	220242	0	None	234	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NC(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C	nan
	CHEMBL4282364	220210	0	None	1071	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NC(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NC(CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)CC(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C	nan
	CHEMBL3102926	217813	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		C=CCCC[C@](C)(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@](C)(CCCC=C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)CC)C(C)C	10.1021/ml400257h
	CHEMBL4283432	220219	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NC(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCNC(=N)N)CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C	nan
	CHEMBL3102927	217814	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		C=CCCC[C@](C)(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@](C)(CCCC=C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)CC)C(C)C	10.1021/ml400257h
	CHEMBL3105019	217849	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@]1(C)CCCC/C=C\CCCC[C@@](C)(C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)CC)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(C)C	10.1021/ml400257h
	CHEMBL4294843	220312	0	None	-11	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)NC(CC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)CC(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C	nan
	CHEMBL4281814	220203	0	None	-58	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C	nan
	CHEMBL4284858	220228	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)NC(C)(C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C	nan
	CHEMBL4287451	220248	0	None	426	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)NC(CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)NC(CCC(N)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C	nan
	CHEMBL3102928	217815	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		C=CCCC[C@](C)(NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@](C)(CCCC=C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)CC	10.1021/ml400257h
	CHEMBL4280273	220184	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C	nan
	CHEMBL4277709	220156	0	None	-870	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C	nan
	CHEMBL4278228	220167	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CNC[C@@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O	nan
	CHEMBL4281905	220205	0	None	1	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C	nan
	CHEMBL4285866	220237	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CC(CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)CC(CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C	nan
	CHEMBL3102920	217807	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assayAgonist activity at human VPAC2 expressed in CHO Flp-in cells assessed as accumulation of cAMP after 30 mins by TR-FRET assay	ChEMBL		None	None	None		None	10.1021/ml400257h
	CHEMBL4277783	220158	0	None	1	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)CC(NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CC(CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)C(C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C	nan
	CHEMBL4284839	220227	0	None	-11	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)CC(CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C	nan
	CHEMBL4280734	220188	0	None	-223	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C	nan
	CHEMBL4284961	220230	0	None	9	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H]1CNC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)CC(Cc1ccc(O)cc1)NC(=O)CC(CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(=O)NC(CCCCN)CC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCCC(=O)N[C@H](C(=O)O)[C@@H](C)O	nan
	CHEMBL4278811	220171	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assayAgonist activity at human VIPR2 expressed in CHOK1 cells assessed as intracellular cAMP accumulation after 60 mins by PathHunter assay	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)CC(CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)CC(CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CC(NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CC(CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(C)C)[C@@H](C)O)C(C)O)C(C)C)C(=O)NC(CC(=O)N[C@@H](CC(N)=O)C(=O)O)CC(C)C	nan
	11570626	9328	46	None	-794	9	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counterAntagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter	ChEMBL	587	9	2	5	7.5	COc1ccc2c(c1)ccc(c2)c1cc(nn1[C@H](c1ccc(cc1)C(=O)NCCC(=O)O)C)c1cc(Cl)cc(c1)Cl	10.1021/jm300579z
	9135	9328	46	None	-794	9	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counterAntagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter	ChEMBL	587	9	2	5	7.5	COc1ccc2c(c1)ccc(c2)c1cc(nn1[C@H](c1ccc(cc1)C(=O)NCCC(=O)O)C)c1cc(Cl)cc(c1)Cl	10.1021/jm300579z
	CHEMBL1933349	9328	46	None	-794	9	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counterAntagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter	ChEMBL	587	9	2	5	7.5	COc1ccc2c(c1)ccc(c2)c1cc(nn1[C@H](c1ccc(cc1)C(=O)NCCC(=O)O)C)c1cc(Cl)cc(c1)Cl	10.1021/jm300579z
	DB12044	9328	46	None	-794	9	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counterAntagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter	ChEMBL	587	9	2	5	7.5	COc1ccc2c(c1)ccc(c2)c1cc(nn1[C@H](c1ccc(cc1)C(=O)NCCC(=O)O)C)c1cc(Cl)cc(c1)Cl	10.1021/jm300579z
	60170971	88176	0	None	-186	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counterAntagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter	ChEMBL	587	9	2	5	7.5	COc1ccc2cc(-c3cc(-c4ccc(Cl)c(Cl)c4)nn3[C@@H](C)c3ccc(C(=O)NCCC(=O)O)cc3)ccc2c1	10.1021/jm300579z
	CHEMBL2159348	88176	0	None	-186	3	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counterAntagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter	ChEMBL	587	9	2	5	7.5	COc1ccc2cc(-c3cc(-c4ccc(Cl)c(Cl)c4)nn3[C@@H](C)c3ccc(C(=O)NCCC(=O)O)cc3)ccc2c1	10.1021/jm300579z
	60170970	88175	0	None	-281	4	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counterAntagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter	ChEMBL	587	9	2	5	7.5	COc1ccc2cc(-c3cc(-c4cc(Cl)ccc4Cl)nn3[C@@H](C)c3ccc(C(=O)NCCC(=O)O)cc3)ccc2c1	10.1021/jm300579z
	CHEMBL2159347	88175	0	None	-281	4	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counterAntagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter	ChEMBL	587	9	2	5	7.5	COc1ccc2cc(-c3cc(-c4cc(Cl)ccc4Cl)nn3[C@@H](C)c3ccc(C(=O)NCCC(=O)O)cc3)ccc2c1	10.1021/jm300579z
	60171059	88177	0	None	-794	4	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counterAntagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter	ChEMBL	621	9	2	5	7.9	COc1ccc2cc(-c3cc(-c4cc(Cl)cc(C(F)(F)F)c4)nn3[C@@H](C)c3ccc(C(=O)NCCC(=O)O)cc3)ccc2c1	10.1021/jm300579z
	CHEMBL2159349	88177	0	None	-794	4	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counterAntagonist activity at human VPAC2 expressed in CHO cells assessed as inhibition of glucagon-induced cAMP accumulation preincubated for 30 mins prior to glucagon challenge measured after 30 mins post glucagon challenge by liquid scintillation counter	ChEMBL	621	9	2	5	7.9	COc1ccc2cc(-c3cc(-c4cc(Cl)cc(C(F)(F)F)c4)nn3[C@@H](C)c3ccc(C(=O)NCCC(=O)O)cc3)ccc2c1	10.1021/jm300579z
	90154832	159898	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced cAMP accumulation incubated for 30 mins by HTRF assayAntagonist activity at human VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced cAMP accumulation incubated for 30 mins by HTRF assay	ChEMBL	539	11	4	7	2.3	O=C(N[C@H]1c2ccccc2C[C@H]1O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc([N+](=O)[O-])cc1	nan
	CHEMBL3976408	159898	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced cAMP accumulation incubated for 30 mins by HTRF assayAntagonist activity at human VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced cAMP accumulation incubated for 30 mins by HTRF assay	ChEMBL	539	11	4	7	2.3	O=C(N[C@H]1c2ccccc2C[C@H]1O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc([N+](=O)[O-])cc1	nan
	168298339	199488	0	None	-1	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at VPAC2 in human SH-SY5Y cells assessed as inhibition of PACAP38-induced cAMP accumulation pre-incubated for 30 mins followed by agonist addition and measured after 75 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAntagonist activity at VPAC2 in human SH-SY5Y cells assessed as inhibition of PACAP38-induced cAMP accumulation pre-incubated for 30 mins followed by agonist addition and measured after 75 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	4137	147	67	59	-16.2	CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](CCS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C)C(C)C	10.1021/acs.jmedchem.0c01396
	CHEMBL5219662	199488	0	None	-1	3	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at VPAC2 in human SH-SY5Y cells assessed as inhibition of PACAP38-induced cAMP accumulation pre-incubated for 30 mins followed by agonist addition and measured after 75 mins by Eu-cAMP tracer based LANCE ultra cAMP assayAntagonist activity at VPAC2 in human SH-SY5Y cells assessed as inhibition of PACAP38-induced cAMP accumulation pre-incubated for 30 mins followed by agonist addition and measured after 75 mins by Eu-cAMP tracer based LANCE ultra cAMP assay	ChEMBL	4137	147	67	59	-16.2	CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](CCS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C)C(C)C	10.1021/acs.jmedchem.0c01396
	1152	10767	16	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	16129679	10767	16	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	53395115	10767	16	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	91898389	10767	16	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	CHEMBL1981592	10767	16	None	-3	8	Human	7.3	pEC50	=	7.3	Functional	calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	16133238	9764	0	None	-85	6	Human	7.6	pEC50	=	7.6	Functional	calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	2257	9764	0	None	-85	6	Human	7.6	pEC50	=	7.6	Functional	calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	44134520	9764	0	None	-85	6	Human	7.6	pEC50	=	7.6	Functional	calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	2258	9765	0	None	-17	4	Human	7.7	pEC50	=	7.7	Functional	calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	1152	10767	16	None	-3	8	Human	7.8	pEC50	=	7.8	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	10570056
	16129679	10767	16	None	-3	8	Human	7.8	pEC50	=	7.8	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	10570056
	53395115	10767	16	None	-3	8	Human	7.8	pEC50	=	7.8	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	10570056
	91898389	10767	16	None	-3	8	Human	7.8	pEC50	=	7.8	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	10570056
	CHEMBL1981592	10767	16	None	-3	8	Human	7.8	pEC50	=	7.8	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	10570056
	2272	9852	0	None	14	3	Human	8.3	pEC50	=	8.3	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	2259	10119	0	None	190	4	Human	8.3	pEC50	=	8.3	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	10570056
	1152	10767	16	None	-3	8	Human	9.2	pEC50	=	9.2	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	16129679	10767	16	None	-3	8	Human	9.2	pEC50	=	9.2	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	53395115	10767	16	None	-3	8	Human	9.2	pEC50	=	9.2	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	91898389	10767	16	None	-3	8	Human	9.2	pEC50	=	9.2	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	CHEMBL1981592	10767	16	None	-3	8	Human	9.2	pEC50	=	9.2	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	2258	9765	0	None	-17	4	Human	9.3	pEC50	=	9.3	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	129887154	7370	0	None	177	3	Human	9.4	pEC50	=	9.4	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	11978642
	155817438	7370	0	None	177	3	Human	9.4	pEC50	=	9.4	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	11978642
	16214732	7370	0	None	177	3	Human	9.4	pEC50	=	9.4	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	11978642
	2269	7370	0	None	177	3	Human	9.4	pEC50	=	9.4	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	11978642
	2281	7370	0	None	177	3	Human	9.4	pEC50	=	9.4	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	11978642
	16133238	9764	0	None	-85	6	Human	9.4	pEC50	=	9.4	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	2257	9764	0	None	-85	6	Human	9.4	pEC50	=	9.4	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	44134520	9764	0	None	-85	6	Human	9.4	pEC50	=	9.4	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	2272	9852	0	None	14	3	Human	8.4	pEC50	=	8.4	Functional	inhibition of calcium influx stimulated by 30nM VIP in CHO cells stably expressing recombinant receptorinhibition of calcium influx stimulated by 30nM VIP in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	2278	7116	0	None	-4168	3	Human	5.9	pEC50	=	5.9	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10801840
	1152	10767	16	None	-3	8	Human	7.9	pEC50	=	7.9	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9152366
	16129679	10767	16	None	-3	8	Human	7.9	pEC50	=	7.9	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9152366
	53395115	10767	16	None	-3	8	Human	7.9	pEC50	=	7.9	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9152366
	91898389	10767	16	None	-3	8	Human	7.9	pEC50	=	7.9	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9152366
	CHEMBL1981592	10767	16	None	-3	8	Human	7.9	pEC50	=	7.9	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9152366
	16133238	9764	0	None	-85	6	Human	8.4	pEC50	=	8.4	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
	2257	9764	0	None	-85	6	Human	8.4	pEC50	=	8.4	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
	44134520	9764	0	None	-85	6	Human	8.4	pEC50	=	8.4	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
	2276	10118	0	None	316	2	Human	8.5	pEC50	=	8.5	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9152366
	1152	10767	16	None	-3	8	Human	8.5	pEC50	=	8.5	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
	16129679	10767	16	None	-3	8	Human	8.5	pEC50	=	8.5	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
	53395115	10767	16	None	-3	8	Human	8.5	pEC50	=	8.5	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
	91898389	10767	16	None	-3	8	Human	8.5	pEC50	=	8.5	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
	CHEMBL1981592	10767	16	None	-3	8	Human	8.5	pEC50	=	8.5	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
	2259	10119	0	None	190	4	Human	8.7	pEC50	=	8.7	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
	1152	10767	16	None	-3	8	Human	9.3	pEC50	=	9.3	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10801840
	16129679	10767	16	None	-3	8	Human	9.3	pEC50	=	9.3	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10801840
	53395115	10767	16	None	-3	8	Human	9.3	pEC50	=	9.3	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10801840
	91898389	10767	16	None	-3	8	Human	9.3	pEC50	=	9.3	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10801840
	CHEMBL1981592	10767	16	None	-3	8	Human	9.3	pEC50	=	9.3	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10801840
	2278	7116	0	None	-4168	3	Human	5.0	pEC50	>	5	Functional	calcium influx in CHO cells stably expressing recombinant receptorcalcium influx in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	2278	7116	0	None	-4168	3	Human	5.0	pEC50	>	5	Functional	cyclic AMP formation in CHO cells stably expressing recombinant receptorcyclic AMP formation in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633
	3842	9214	0	None	-1584	5	Human	6.0	pEC50	>	6	Functional	stimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptorstimulation of cyclic AMP formation in CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
	2272	9852	0	None	14	3	Human	7.6	pIC50	=	7.6	Functional	inhibition of cyclic AMP formation stimulated by 0.3nM VIP in CHO cells stably expressing recombinant receptorinhibition of cyclic AMP formation stimulated by 0.3nM VIP in CHO cells stably expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	16930633

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		CHEMBL524852	222400	6	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysis	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O	10.1016/j.ejmech.2015.09.017
		118334911	151094	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	534	10	4	5	2.8	O=C(N[C@H]1c2ccccc2C[C@H]1O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc2c(c1)CCC2	nan
		CHEMBL3905363	151094	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	534	10	4	5	2.8	O=C(N[C@H]1c2ccccc2C[C@H]1O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc2c(c1)CCC2	nan
		73890927	155674	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	524	11	4	6	2.4	COc1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		CHEMBL3941654	155674	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	524	11	4	6	2.4	COc1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		118334840	155309	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	522	11	4	5	2.9	CCc1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		CHEMBL3938565	155309	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	522	11	4	5	2.9	CCc1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		118334843	156031	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	508	10	4	5	2.7	Cc1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		CHEMBL3944350	156031	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	508	10	4	5	2.7	Cc1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		2263	7045	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]PACAP27 from human VPAC2 receptor expressed in CHO cellsDisplacement of [125I]PACAP27 from human VPAC2 receptor expressed in CHO cells	ChEMBL		None	None	None		None	10.1021/jm0609059
		44566111	7045	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]PACAP27 from human VPAC2 receptor expressed in CHO cellsDisplacement of [125I]PACAP27 from human VPAC2 receptor expressed in CHO cells	ChEMBL		None	None	None		None	10.1021/jm0609059
		CHEMBL219499	7045	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]PACAP27 from human VPAC2 receptor expressed in CHO cellsDisplacement of [125I]PACAP27 from human VPAC2 receptor expressed in CHO cells	ChEMBL		None	None	None		None	10.1021/jm0609059
		90154832	159898	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	539	11	4	7	2.3	O=C(N[C@H]1c2ccccc2C[C@H]1O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc([N+](=O)[O-])cc1	nan
		CHEMBL3976408	159898	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	539	11	4	7	2.3	O=C(N[C@H]1c2ccccc2C[C@H]1O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc([N+](=O)[O-])cc1	nan
		118334841	160300	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	519	10	4	6	2.2	N#Cc1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		CHEMBL3979900	160300	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	519	10	4	6	2.2	N#Cc1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		118334918	155631	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	522	10	4	5	3.0	Cc1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1C	nan
		CHEMBL3941270	155631	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	522	10	4	5	3.0	Cc1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1C	nan
		118334912	161101	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	572	11	4	7	1.8	CS(=O)(=O)c1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		CHEMBL3986723	161101	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	572	11	4	7	1.8	CS(=O)(=O)c1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		118334831	153894	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	552	10	4	7	2.1	O=C(N[C@H]1c2ccccc2C[C@H]1O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc2c(c1)OCCO2	nan
		CHEMBL3927475	153894	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	552	10	4	7	2.1	O=C(N[C@H]1c2ccccc2C[C@H]1O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc2c(c1)OCCO2	nan
		CHEMBL507480	221114	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysis	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O	10.1016/j.ejmech.2015.09.017
		90154832	159898	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Antagonist activity at human VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced beta-arrestin 2 binding incubated for 2 hrs by beta-galactosidase assayAntagonist activity at human VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced beta-arrestin 2 binding incubated for 2 hrs by beta-galactosidase assay	ChEMBL	539	11	4	7	2.3	O=C(N[C@H]1c2ccccc2C[C@H]1O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc([N+](=O)[O-])cc1	nan
		CHEMBL3976408	159898	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Antagonist activity at human VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced beta-arrestin 2 binding incubated for 2 hrs by beta-galactosidase assayAntagonist activity at human VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced beta-arrestin 2 binding incubated for 2 hrs by beta-galactosidase assay	ChEMBL	539	11	4	7	2.3	O=C(N[C@H]1c2ccccc2C[C@H]1O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc([N+](=O)[O-])cc1	nan
		118334842	160631	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	562	10	4	5	3.4	O=C(N[C@H]1c2ccccc2C[C@H]1O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc(C(F)(F)F)cc1	nan
		CHEMBL3982797	160631	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	562	10	4	5	3.4	O=C(N[C@H]1c2ccccc2C[C@H]1O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc(C(F)(F)F)cc1	nan
		CHEMBL440082	220639	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]PACAP27 from human VPAC2 receptor expressed in CHO cellsDisplacement of [125I]PACAP27 from human VPAC2 receptor expressed in CHO cells	ChEMBL		None	None	None		CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CS)C(=O)O	10.1021/jm0609059
		118334830	161024	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	528	10	4	5	3.0	O=C(N[C@H]1c2ccccc2C[C@H]1O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc(Cl)cc1	nan
		CHEMBL3986225	161024	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	528	10	4	5	3.0	O=C(N[C@H]1c2ccccc2C[C@H]1O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc(Cl)cc1	nan
		118334834	159090	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	536	11	4	5	3.5	CC(C)c1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		CHEMBL3969613	159090	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	536	11	4	5	3.5	CC(C)c1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		127035881	143263	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysis	ChEMBL	3264	105	48	45	-10.6	CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccc(F)cc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O	10.1016/j.ejmech.2015.09.017
		CHEMBL3736134	143263	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysis	ChEMBL	3264	105	48	45	-10.6	CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccc(F)cc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O	10.1016/j.ejmech.2015.09.017
		127035881	143263	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysis	ChEMBL	3264	105	48	45	-10.6	CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccc(F)cc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O	10.1016/j.ejmech.2015.09.017
		CHEMBL3736134	143263	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysis	ChEMBL	3264	105	48	45	-10.6	CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccc(F)cc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O	10.1016/j.ejmech.2015.09.017
		90154607	160583	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	538	10	4	7	2.1	O=C(N[C@H]1c2ccccc2C[C@H]1O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc2c(c1)OCO2	nan
		CHEMBL3982346	160583	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	538	10	4	7	2.1	O=C(N[C@H]1c2ccccc2C[C@H]1O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc2c(c1)OCO2	nan
		118334924	153915	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	542	11	3	5	3.7	CO[C@@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc(Cl)cc1	nan
		CHEMBL3927669	153915	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	542	11	3	5	3.7	CO[C@@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc(Cl)cc1	nan
		118334910	151426	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	538	11	5	6	2.4	CC(O)c1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		CHEMBL3908152	151426	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	538	11	5	6	2.4	CC(O)c1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		118334914	158138	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	536	12	4	5	3.3	CCCc1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		CHEMBL3961248	158138	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	536	12	4	5	3.3	CCCc1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		118334919	160314	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	552	13	4	6	3.1	CCCOc1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		CHEMBL3980013	160314	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	552	13	4	6	3.1	CCCOc1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		73890939	159610	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	536	11	4	6	2.6	CC(=O)c1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		CHEMBL3973956	159610	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	536	11	4	6	2.6	CC(=O)c1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		118334917	157982	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	566	13	4	6	3.5	CCC(C)Oc1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		CHEMBL3959870	157982	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	566	13	4	6	3.5	CCC(C)Oc1ccc(S(=O)(=O)NC[C@@H](O)C[C@@H](Cc2ccccc2)C(=O)N[C@H]2c3ccccc3C[C@H]2O)cc1	nan
		118334925	149167	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	550	12	3	6	3.2	CO[C@@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc(C(C)=O)cc1	nan
		CHEMBL3889643	149167	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	550	12	3	6	3.2	CO[C@@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc(C(C)=O)cc1	nan
		127034614	143281	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysis	ChEMBL	3246	105	48	45	-10.8	CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccccc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O	10.1016/j.ejmech.2015.09.017
		CHEMBL3736230	143281	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysis	ChEMBL	3246	105	48	45	-10.8	CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccccc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O	10.1016/j.ejmech.2015.09.017
		127034614	143281	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysis	ChEMBL	3246	105	48	45	-10.8	CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccccc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O	10.1016/j.ejmech.2015.09.017
		CHEMBL3736230	143281	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysisDisplacement of Ac-[125I]-PACAP27 from recombinant human VPAC2 expressed in CHO cells after 90 mins by gamma counting analysis	ChEMBL	3246	105	48	45	-10.8	CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(C#Cc2ccccc2)cc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)C(C)C)[C@@H](C)O	10.1016/j.ejmech.2015.09.017
		118334931	149220	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	566	11	3	7	2.8	CO[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc2c(c1)OCCO2	nan
		CHEMBL3890096	149220	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	566	11	3	7	2.8	CO[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc2c(c1)OCCO2	nan
		118334909	156191	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	512	10	4	5	2.5	O=C(N[C@H]1c2ccccc2C[C@H]1O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc(F)cc1	nan
		CHEMBL3945729	156191	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Antagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assayAntagonist activity at recombinant human N-terminal signal peptide/FLAG epitope-tagged Rluc8-fused VIPR2 expressed in HEK293 cells assessed as inhibition of VIP-induced human mVenus-beta-arrestin2 binding preincubated for 5 mins with luciferin, coelenterazine H followed by VIP addition measured after 5 mins by BRET assay	ChEMBL	512	10	4	5	2.5	O=C(N[C@H]1c2ccccc2C[C@H]1O)[C@H](Cc1ccccc1)C[C@H](O)CNS(=O)(=O)c1ccc(F)cc1	nan
		3842	9214	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		1155	10345	0	None	-	2	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		16129665	10345	0	None	-	2	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		3643	10345	0	None	-	2	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		CHEMBL1201488	10345	0	None	-	2	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		DB00021	10345	0	None	-	2	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		3293	7256	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		3293	7256	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		1155	10345	0	None	-	2	Human	5.3	pIC50	=	5.3	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		16129665	10345	0	None	-	2	Human	5.3	pIC50	=	5.3	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		3643	10345	0	None	-	2	Human	5.3	pIC50	=	5.3	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		CHEMBL1201488	10345	0	None	-	2	Human	5.3	pIC50	=	5.3	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		DB00021	10345	0	None	-	2	Human	5.3	pIC50	=	5.3	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		1152	10767	16	None	-5	4	Human	8.3	pIC50	=	8.3	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		16129679	10767	16	None	-5	4	Human	8.3	pIC50	=	8.3	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		53395115	10767	16	None	-5	4	Human	8.3	pIC50	=	8.3	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		91898389	10767	16	None	-5	4	Human	8.3	pIC50	=	8.3	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		CHEMBL1981592	10767	16	None	-5	4	Human	8.3	pIC50	=	8.3	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		1152	10767	16	None	-	4	Rat	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		16129679	10767	16	None	-	4	Rat	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		53395115	10767	16	None	-	4	Rat	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		91898389	10767	16	None	-	4	Rat	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		CHEMBL1981592	10767	16	None	-	4	Rat	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		129887154	7370	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	inhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11978642
		155817438	7370	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	inhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11978642
		16214732	7370	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	inhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11978642
		2269	7370	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	inhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11978642
		2281	7370	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	inhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11978642
		16133238	9764	0	None	-	3	Human	7.7	pIC50	=	7.7	Binding	inhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11978642
		2257	9764	0	None	-	3	Human	7.7	pIC50	=	7.7	Binding	inhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11978642
		44134520	9764	0	None	-	3	Human	7.7	pIC50	=	7.7	Binding	inhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-PACAP-27 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11978642
		131850923	9851	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9437716
		155817437	9851	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9437716
		16154651	9851	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9437716
		2268	9851	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9437716
		131850923	9851	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9437716
		155817437	9851	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9437716
		16154651	9851	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9437716
		2268	9851	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9437716
		2266	9669	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
		16133238	9764	0	None	-	3	Human	7.6	pIC50	=	7.6	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
		2257	9764	0	None	-	3	Human	7.6	pIC50	=	7.6	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
		44134520	9764	0	None	-	3	Human	7.6	pIC50	=	7.6	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
		1152	10767	16	None	-5	4	Human	7.7	pIC50	=	7.7	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
		16129679	10767	16	None	-5	4	Human	7.7	pIC50	=	7.7	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
		53395115	10767	16	None	-5	4	Human	7.7	pIC50	=	7.7	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
		91898389	10767	16	None	-5	4	Human	7.7	pIC50	=	7.7	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
		CHEMBL1981592	10767	16	None	-5	4	Human	7.7	pIC50	=	7.7	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
		2259	10119	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10570056
		2259	10119	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
		2259	10119	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9145428
		1155	10345	0	None	-	2	Rat	4.5	pIC50	=	4.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		16129665	10345	0	None	-	2	Rat	4.5	pIC50	=	4.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		3643	10345	0	None	-	2	Rat	4.5	pIC50	=	4.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		CHEMBL1201488	10345	0	None	-	2	Rat	4.5	pIC50	=	4.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		DB00021	10345	0	None	-	2	Rat	4.5	pIC50	=	4.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		1155	10345	0	None	-	2	Human	5.3	pIC50	=	5.3	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		16129665	10345	0	None	-	2	Human	5.3	pIC50	=	5.3	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		3643	10345	0	None	-	2	Human	5.3	pIC50	=	5.3	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		CHEMBL1201488	10345	0	None	-	2	Human	5.3	pIC50	=	5.3	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		DB00021	10345	0	None	-	2	Human	5.3	pIC50	=	5.3	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		131850923	9851	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10570056
		155817437	9851	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10570056
		16154651	9851	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10570056
		2268	9851	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10570056
		2273	9883	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		2273	9883	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		16133238	9764	0	None	-	3	Human	8.0	pIC50	=	8	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		16133238	9764	0	None	-	3	Rat	8.0	pIC50	=	8	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		2257	9764	0	None	-	3	Human	8.0	pIC50	=	8	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		2257	9764	0	None	-	3	Rat	8.0	pIC50	=	8	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		44134520	9764	0	None	-	3	Human	8.0	pIC50	=	8	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		44134520	9764	0	None	-	3	Rat	8.0	pIC50	=	8	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		2275	9888	0	None	-	0	Human	8.0	pIC50	=	8	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		1152	10767	16	None	-5	4	Human	8.0	pIC50	=	8	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9726637
		1152	10767	16	None	-	4	Rat	8.0	pIC50	=	8	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9726637
		16129679	10767	16	None	-5	4	Human	8.0	pIC50	=	8	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9726637
		16129679	10767	16	None	-	4	Rat	8.0	pIC50	=	8	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9726637
		53395115	10767	16	None	-5	4	Human	8.0	pIC50	=	8	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9726637
		53395115	10767	16	None	-	4	Rat	8.0	pIC50	=	8	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9726637
		91898389	10767	16	None	-5	4	Human	8.0	pIC50	=	8	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9726637
		91898389	10767	16	None	-	4	Rat	8.0	pIC50	=	8	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9726637
		CHEMBL1981592	10767	16	None	-5	4	Human	8.0	pIC50	=	8	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9726637
		CHEMBL1981592	10767	16	None	-	4	Rat	8.0	pIC50	=	8	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9726637
		2275	9888	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		1152	10767	16	None	-	4	Rat	8.4	pIC50	=	8.4	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		16129679	10767	16	None	-	4	Rat	8.4	pIC50	=	8.4	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		53395115	10767	16	None	-	4	Rat	8.4	pIC50	=	8.4	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		91898389	10767	16	None	-	4	Rat	8.4	pIC50	=	8.4	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		CHEMBL1981592	10767	16	None	-	4	Rat	8.4	pIC50	=	8.4	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		16132369	8699	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		16132369	8699	0	None	-	1	Rat	8.5	pIC50	=	8.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		2280	8699	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		2280	8699	0	None	-	1	Rat	8.5	pIC50	=	8.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		53230038	8699	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		53230038	8699	0	None	-	1	Rat	8.5	pIC50	=	8.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		2271	9670	0	None	-	0	Rat	8.5	pIC50	=	8.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9726637
		1152	10767	16	None	-5	4	Human	8.5	pIC50	=	8.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10570056
		1152	10767	16	None	-5	4	Human	8.5	pIC50	=	8.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		16129679	10767	16	None	-5	4	Human	8.5	pIC50	=	8.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10570056
		16129679	10767	16	None	-5	4	Human	8.5	pIC50	=	8.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		53395115	10767	16	None	-5	4	Human	8.5	pIC50	=	8.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10570056
		53395115	10767	16	None	-5	4	Human	8.5	pIC50	=	8.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		91898389	10767	16	None	-5	4	Human	8.5	pIC50	=	8.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10570056
		91898389	10767	16	None	-5	4	Human	8.5	pIC50	=	8.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		CHEMBL1981592	10767	16	None	-5	4	Human	8.5	pIC50	=	8.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10570056
		CHEMBL1981592	10767	16	None	-5	4	Human	8.5	pIC50	=	8.5	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9928018
		2272	9852	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11068102
		2271	9670	0	None	-	0	Human	9.0	pIC50	=	9	Binding	inhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]Ro25 1553 binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9726637
		3842	9214	0	None	-	0	Human	4.5	pIC50	>	4.5	Binding	Inhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptorInhibition of [125I]VIP binding in membranes from CHO cells expressing recombinant receptor	Guide to Pharmacology		None	None	None		None	9437714
		3842	9214	0	None	-	0	Human	6.0	pIC50	>	6	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11931347
		129887154	7370	0	None	-	1	Human	9.2	pKd	=	9.2	Binding	binding to membranes from CHO cells stably expressing the recombinant receptorbinding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11978642
		155817438	7370	0	None	-	1	Human	9.2	pKd	=	9.2	Binding	binding to membranes from CHO cells stably expressing the recombinant receptorbinding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11978642
		16214732	7370	0	None	-	1	Human	9.2	pKd	=	9.2	Binding	binding to membranes from CHO cells stably expressing the recombinant receptorbinding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11978642
		2269	7370	0	None	-	1	Human	9.2	pKd	=	9.2	Binding	binding to membranes from CHO cells stably expressing the recombinant receptorbinding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11978642
		2281	7370	0	None	-	1	Human	9.2	pKd	=	9.2	Binding	binding to membranes from CHO cells stably expressing the recombinant receptorbinding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	11978642
		53314964	223100	0	125I-VIP	-1	3	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	3325	113	51	48	-14.6	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N	None
		53314964	223100	0	125I-VIP	-5	3	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	3325	113	51	48	-14.6	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N	None
		53314964	223100	0	125I-VIP	-1	3	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	3325	113	51	48	-14.6	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N	None
		53314964	223100	0	125I-VIP	-5	3	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	3325	113	51	48	-14.6	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N	None
		53314964	223100	0	125I-VIP	-5	3	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	3325	113	51	48	-14.6	CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(C=C1)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)N	None
		1152	10767	16	None	-5	4	Human	7.8	pKi	=	7.8	Binding	inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9152366
		16129679	10767	16	None	-5	4	Human	7.8	pKi	=	7.8	Binding	inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9152366
		53395115	10767	16	None	-5	4	Human	7.8	pKi	=	7.8	Binding	inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9152366
		91898389	10767	16	None	-5	4	Human	7.8	pKi	=	7.8	Binding	inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9152366
		CHEMBL1981592	10767	16	None	-5	4	Human	7.8	pKi	=	7.8	Binding	inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9152366
		2276	10118	0	None	316	2	Human	8.0	pKi	=	8	Binding	inhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9152366
		2278	7116	0	None	-316	2	Human	5.6	pKi	=	5.6	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10801840
		1152	10767	16	None	-5	4	Human	8.8	pKi	=	8.8	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10801840
		16129679	10767	16	None	-5	4	Human	8.8	pKi	=	8.8	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10801840
		53395115	10767	16	None	-5	4	Human	8.8	pKi	=	8.8	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10801840
		91898389	10767	16	None	-5	4	Human	8.8	pKi	=	8.8	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10801840
		CHEMBL1981592	10767	16	None	-5	4	Human	8.8	pKi	=	8.8	Binding	inhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from CHO cells stably expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	10801840
		1152	10767	16	None	-5	4	Human	8.7	pKi	=	8.7	Binding	inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9454823
		16129679	10767	16	None	-5	4	Human	8.7	pKi	=	8.7	Binding	inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9454823
		53395115	10767	16	None	-5	4	Human	8.7	pKi	=	8.7	Binding	inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9454823
		91898389	10767	16	None	-5	4	Human	8.7	pKi	=	8.7	Binding	inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9454823
		CHEMBL1981592	10767	16	None	-5	4	Human	8.7	pKi	=	8.7	Binding	inhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptorinhibition of [125I]-VIP binding to membranes from COS cells transiently expressing the recombinant receptor	Guide to Pharmacology		None	None	None		None	9454823

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