Biased Signaling Atlas

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1067	1709	128	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	119	1709	128	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	1262	1709	128	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	5410	1709	128	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	6992099	1709	128	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	CHEMBL96	1709	128	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	DB02530	1709	128	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	11701095	188707	2	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	161	1	2	2	0.9	CP(=O)(O)C1=CCC(N)C1	10.1021/jm7015842
	CHEMBL504482	188707	2	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	161	1	2	2	0.9	CP(=O)(O)C1=CCC(N)C1	10.1021/jm7015842
	24895101	172039	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	161	1	2	2	0.9	CP(=O)(O)C1=CC[C@H](N)C1	10.1021/jm7015842
	CHEMBL447171	172039	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	161	1	2	2	0.9	CP(=O)(O)C1=CC[C@H](N)C1	10.1021/jm7015842
	24895106	170892	1	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	161	1	2	2	0.9	CP(=O)(O)C1=CC[C@@H](N)C1	10.1021/jm7015842
	CHEMBL445449	170892	1	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	161	1	2	2	0.9	CP(=O)(O)C1=CC[C@@H](N)C1	10.1021/jm7015842
	16686147	2296	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	141	3	2	2	-0.3	NC[C@H](CP(=O)O)F	None
	7705	2296	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	141	3	2	2	-0.3	NC[C@H](CP(=O)O)F	None
	CHEMBL448343	2296	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	141	3	2	2	-0.3	NC[C@H](CP(=O)O)F	None
	DB11920	2296	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	141	3	2	2	-0.3	NC[C@H](CP(=O)O)F	None
	1067	1709	128	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	119	1709	128	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	1262	1709	128	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	5410	1709	128	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	6992099	1709	128	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	CHEMBL96	1709	128	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	DB02530	1709	128	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	1064	568	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	3428	568	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	44602	568	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	6918881	568	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	CHEMBL301742	568	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	DB00181	568	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	DB08891	568	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	1069	892	49	None	-	1	Rat	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	7650685
	1069	892	49	None	-	1	Rat	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	9069281
	107699	892	49	None	-	1	Rat	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	7650685
	107699	892	49	None	-	1	Rat	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	9069281
	CHEMBL40157	892	49	None	-	1	Rat	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	7650685
	CHEMBL40157	892	49	None	-	1	Rat	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	9069281
	1081	96	0	None	-	1	Rat	5.6	pIC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	122	3	2	2	0.1	NCCC[P+](=O)O	9069281
	5381	96	0	None	-	1	Rat	5.6	pIC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	122	3	2	2	0.1	NCCC[P+](=O)O	9069281
	6335948	96	0	None	-	1	Rat	5.6	pIC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	122	3	2	2	0.1	NCCC[P+](=O)O	9069281
	1075	3555	0	None	-	1	Rat	6.4	pIC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	2	2	3	0.2	OC(=O)C[C@@H]1OCC(NC1)(C)C	7562513
	5311429	3555	0	None	-	1	Rat	6.4	pIC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	2	2	3	0.2	OC(=O)C[C@@H]1OCC(NC1)(C)C	7562513
	86294992	3555	0	None	-	1	Rat	6.4	pIC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	2	2	3	0.2	OC(=O)C[C@@H]1OCC(NC1)(C)C	7562513
	CHEMBL1895916	3555	0	None	-	1	Rat	6.4	pIC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	2	2	3	0.2	OC(=O)C[C@@H]1OCC(NC1)(C)C	7562513
	1072	897	0	None	-	1	Rat	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	421	10	3	5	3.2	COc1ccc(cc1)CP(=O)(C[C@H](CN([C@@H](c1cccc(c1)C(=O)O)C)C)O)O	9069281
	3429	897	0	None	-	1	Rat	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	421	10	3	5	3.2	COc1ccc(cc1)CP(=O)(C[C@H](CN([C@@H](c1cccc(c1)C(=O)O)C)C)O)O	9069281
	5310936	897	0	None	-	1	Rat	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	421	10	3	5	3.2	COc1ccc(cc1)CP(=O)(C[C@H](CN([C@@H](c1cccc(c1)C(=O)O)C)C)O)O	9069281
	1078	3458	0	None	-	1	Rat	3.5	pIC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	249	4	2	3	1.3	NCC(c1ccc(cc1)Cl)CS(=O)(=O)O	9069281
	122150	3458	0	None	-	1	Rat	3.5	pIC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	249	4	2	3	1.3	NCC(c1ccc(cc1)Cl)CS(=O)(=O)O	9069281
	CHEMBL312403	3458	0	None	-	1	Rat	3.5	pIC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	249	4	2	3	1.3	NCC(c1ccc(cc1)Cl)CS(=O)(=O)O	9069281
	1068	68	0	None	-	1	Rat	4.1	pIC50	None	4.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	4	3	4	0.4	NCC(c1ccc(cc1)Cl)(CS(=O)(=O)O)O	9069281
	1564	68	0	None	-	1	Rat	4.1	pIC50	None	4.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	4	3	4	0.4	NCC(c1ccc(cc1)Cl)(CS(=O)(=O)O)O	9069281
	CHEMBL1256573	68	0	None	-	1	Rat	4.1	pIC50	None	4.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	4	3	4	0.4	NCC(c1ccc(cc1)Cl)(CS(=O)(=O)O)O	9069281
	1067	1709	128	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	119	1709	128	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	1262	1709	128	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	5410	1709	128	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	6992099	1709	128	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	CHEMBL96	1709	128	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	DB02530	1709	128	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	10154248	894	0	None	-	1	Human	4.9	pIC50	None	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	4	2	2	0.8	NCCCP(=O)(C(F)F)O	9069281
	1066	894	0	None	-	1	Human	4.9	pIC50	None	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	4	2	2	0.8	NCCCP(=O)(C(F)F)O	9069281
	CHEMBL113553	894	0	None	-	1	Human	4.9	pIC50	None	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	4	2	2	0.8	NCCCP(=O)(C(F)F)O	9069281
	1074	900	0	None	-	1	Rat	8.4	pIC50	None	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	659	15	6	7	4.5	[N-]=[N+]=Nc1cc(O)c(cc1I)C(=O)NCCCCCP(=O)(C[C@H](CN[C@@H](c1cccc(c1)C(=O)O)C)O)O	9069281
	6324595	900	0	None	-	1	Rat	8.4	pIC50	None	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	659	15	6	7	4.5	[N-]=[N+]=Nc1cc(O)c(cc1I)C(=O)NCCCCCP(=O)(C[C@H](CN[C@@H](c1cccc(c1)C(=O)O)C)O)O	9069281
	CHEMBL1909011	900	0	None	-	1	Rat	8.4	pIC50	None	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	659	15	6	7	4.5	[N-]=[N+]=Nc1cc(O)c(cc1I)C(=O)NCCCCCP(=O)(C[C@H](CN[C@@H](c1cccc(c1)C(=O)O)C)O)O	9069281
	1073	898	0	None	-	1	Rat	8.6	pIC50	None	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	646	16	6	6	3.9	O=C(CCc1ccc(c(c1)I)O)NCCCCCP(=O)(C[C@H](CN[C@@H](c1cccc(c1)C(=O)O)C)O)O	9069281
	5311043	898	0	None	-	1	Rat	8.6	pIC50	None	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	646	16	6	6	3.9	O=C(CCc1ccc(c(c1)I)O)NCCCCCP(=O)(C[C@H](CN[C@@H](c1cccc(c1)C(=O)O)C)O)O	9069281
	CHEMBL1909010	898	0	None	-	1	Rat	8.6	pIC50	None	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	646	16	6	6	3.9	O=C(CCc1ccc(c(c1)I)O)NCCCCCP(=O)(C[C@H](CN[C@@H](c1cccc(c1)C(=O)O)C)O)O	9069281
	1070	895	12	None	3	2	Rat	8.8	pIC50	None	8.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	9069281
	1090	895	12	None	3	2	Rat	8.8	pIC50	None	8.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	9069281
	197584	895	12	None	3	2	Rat	8.8	pIC50	None	8.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	9069281
	CHEMBL1213187	895	12	None	3	2	Rat	8.8	pIC50	None	8.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	9069281
	1071	896	0	None	-	1	Rat	9.2	pIC50	None	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	383	9	4	4	3.2	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@@H](c1cccc(c1)C(=O)O)C	9069281
	9800175	896	0	None	-	1	Rat	9.2	pIC50	None	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	383	9	4	4	3.2	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@@H](c1cccc(c1)C(=O)O)C	9069281

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		2284	204073	114	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human GABBR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GABBR1 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	213	4	2	2	1.9	NCC(CC(=O)O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL701	204073	114	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human GABBR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GABBR1 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	213	4	2	2	1.9	NCC(CC(=O)O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		5446	1868	57	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Positive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibition of 7beta forskolin-stimulated cyclic AMP formation after 2 hrs in presence of 0.3 uM GABA relative to 100 uM GABA alonePositive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibition of 7beta forskolin-stimulated cyclic AMP formation after 2 hrs in presence of 0.3 uM GABA relative to 100 uM GABA alone	ChEMBL	337	6	2	7	3.8	CSc1nc(NC2CCCC2)c(c(n1)NC1CCCC1)[N+](=O)[O-]	10.1016/j.bmcl.2017.03.084
		6604928	1868	57	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Positive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibition of 7beta forskolin-stimulated cyclic AMP formation after 2 hrs in presence of 0.3 uM GABA relative to 100 uM GABA alonePositive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibition of 7beta forskolin-stimulated cyclic AMP formation after 2 hrs in presence of 0.3 uM GABA relative to 100 uM GABA alone	ChEMBL	337	6	2	7	3.8	CSc1nc(NC2CCCC2)c(c(n1)NC1CCCC1)[N+](=O)[O-]	10.1016/j.bmcl.2017.03.084
		CHEMBL392394	1868	57	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Positive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibition of 7beta forskolin-stimulated cyclic AMP formation after 2 hrs in presence of 0.3 uM GABA relative to 100 uM GABA alonePositive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibition of 7beta forskolin-stimulated cyclic AMP formation after 2 hrs in presence of 0.3 uM GABA relative to 100 uM GABA alone	ChEMBL	337	6	2	7	3.8	CSc1nc(NC2CCCC2)c(c(n1)NC1CCCC1)[N+](=O)[O-]	10.1016/j.bmcl.2017.03.084
		9964332	10042	0	None	-	0	Rat	6.0	pIC50	=	6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	193	6	2	3	0.6	CC(=O)CCP(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL115162	10042	0	None	-	0	Rat	6.0	pIC50	=	6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	193	6	2	3	0.6	CC(=O)CCP(=O)(O)CCCN	10.1021/jm00017a016
		9813169	9783	2	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	213	5	2	2	1.8	NCCCP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
		CHEMBL113613	9783	2	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	213	5	2	2	1.8	NCCCP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
		28560001	110405	8	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	227	6	2	2	1.8	NCCCP(=O)(O)CCc1ccccc1	10.1021/jm00017a016
		659968	110405	8	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	227	6	2	2	1.8	NCCCP(=O)(O)CCc1ccccc1	10.1021/jm00017a016
		CHEMBL324407	110405	8	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	227	6	2	2	1.8	NCCCP(=O)(O)CCc1ccccc1	10.1021/jm00017a016
		9883500	142329	1	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	318	1	1	2	4.6	CC(=O)[C@H]1CCC2C3CC[C@H]4C[C@H](O)CC[C@]4(C)C3CC[C@@]21C	nan
		CHEMBL38856	142329	1	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	318	1	1	2	4.6	CC(=O)[C@H]1CCC2C3CC[C@H]4C[C@H](O)CC[C@]4(C)C3CC[C@@]21C	nan
		10377028	108607	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	241	8	3	5	-0.1	CCOC(OCC)P(=O)(O)C[C@@H](O)CN	10.1021/jm00017a016
		CHEMBL320533	108607	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	241	8	3	5	-0.1	CCOC(OCC)P(=O)(O)C[C@@H](O)CN	10.1021/jm00017a016
		58227083	124610	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	321	1	1	3	4.0	C[C@]12CC[C@@H](O)C[C@@H]1CCC1C2CC[C@@]2(C)C1CC[C@@H]2[N+](=O)[O-]	nan
		CHEMBL3640615	124610	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	321	1	1	3	4.0	C[C@]12CC[C@@H](O)C[C@@H]1CCC1C2CC[C@@]2(C)C1CC[C@@H]2[N+](=O)[O-]	nan
		9920531	110321	2	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	179	5	2	2	1.3	CC(C)CP(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL323887	110321	2	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	179	5	2	2	1.3	CC(C)CP(=O)(O)CCCN	10.1021/jm00017a016
		10352529	110667	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	191	5	2	3	0.2	NCC(=O)CP(=O)(O)CC1CC1	10.1021/jm00017a016
		CHEMBL325932	110667	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	191	5	2	3	0.2	NCC(=O)CP(=O)(O)CC1CC1	10.1021/jm00017a016
		28559746	9639	55	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	137	3	2	2	0.2	CP(=O)(O)CCCN	10.1021/jm00017a016
		5230	9639	55	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	137	3	2	2	0.2	CP(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL112710	9639	55	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	137	3	2	2	0.2	CP(=O)(O)CCCN	10.1021/jm00017a016
		9920471	9463	3	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	165	5	2	2	1.0	CCCP(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL111890	9463	3	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	165	5	2	2	1.0	CCCP(=O)(O)CCCN	10.1021/jm00017a016
		9964768	110375	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	241	8	3	5	-0.1	CCOC(OCC)P(=O)(O)CC(O)CN	10.1021/jm00017a016
		CHEMBL324244	110375	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	241	8	3	5	-0.1	CCOC(OCC)P(=O)(O)CC(O)CN	10.1021/jm00017a016
		58227084	124611	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	335	1	1	3	4.4	C[C@]12CC[C@@](C)(O)C[C@@H]1CCC1C2CC[C@@]2(C)C1CC[C@@H]2[N+](=O)[O-]	nan
		CHEMBL3640616	124611	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	335	1	1	3	4.4	C[C@]12CC[C@@](C)(O)C[C@@H]1CCC1C2CC[C@@]2(C)C1CC[C@@H]2[N+](=O)[O-]	nan
		9815542	9572	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	195	6	3	3	0.7	CCCC(O)P(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL112408	9572	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	195	6	3	3	0.7	CCCC(O)P(=O)(O)CCCN	10.1021/jm00017a016
		9878233	111300	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	253	8	2	4	1.7	CC(C)OC(OC(C)C)P(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL326622	111300	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	253	8	2	4	1.7	CC(C)OC(OC(C)C)P(=O)(O)CCCN	10.1021/jm00017a016
		10105390	9577	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	233	6	2	2	2.6	NCCCP(=O)(O)CCC1CCCCC1	10.1021/jm00017a016
		CHEMBL112460	9577	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	233	6	2	2	2.6	NCCCP(=O)(O)CCC1CCCCC1	10.1021/jm00017a016
		10466591	9621	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	6	2	3	1.6	NCCCP(=O)(O)CCC1CCCCO1	10.1021/jm00017a016
		CHEMBL112639	9621	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	6	2	3	1.6	NCCCP(=O)(O)CCC1CCCCO1	10.1021/jm00017a016
		44341174	9770	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	343	9	5	5	-0.5	NCCCP(=O)(O)CC(O)CNC(=O)c1ccccc1C(N)=O	10.1021/jm00017a016
		CHEMBL113540	9770	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	343	9	5	5	-0.5	NCCCP(=O)(O)CC(O)CNC(=O)c1ccccc1C(N)=O	10.1021/jm00017a016
		9898878	110665	21	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	151	4	2	2	0.6	CCP(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL325921	110665	21	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	151	4	2	2	0.6	CCP(=O)(O)CCCN	10.1021/jm00017a016
		130023	9776	9	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	207	8	2	2	2.2	CCCCCCP(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL113571	9776	9	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	207	8	2	2	2.2	CCCCCCP(=O)(O)CCCN	10.1021/jm00017a016
		9878836	10126	2	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	281	12	2	4	2.5	CCCCOC(OCCCC)P(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL115664	10126	2	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	281	12	2	4	2.5	CCCCOC(OCCCC)P(=O)(O)CCCN	10.1021/jm00017a016
		9923821	9982	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	335	9	2	4	3.0	CCOC(OCC)P(=O)(O)CC(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
		CHEMBL114812	9982	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	335	9	2	4	3.0	CCOC(OCC)P(=O)(O)CC(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
		9877786	9645	1	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	215	6	2	2	2.0	CCCC(F)(F)P(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL112741	9645	1	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	215	6	2	2	2.0	CCCC(F)(F)P(=O)(O)CCCN	10.1021/jm00017a016
		1069	892	49	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	10.1021/jm00017a016
		107699	892	49	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	10.1021/jm00017a016
		CHEMBL40157	892	49	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	10.1021/jm00017a016
		9856380	9839	2	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	253	10	2	4	1.7	CCCOC(OCCC)P(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL114027	9839	2	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	253	10	2	4	1.7	CCCOC(OCCC)P(=O)(O)CCCN	10.1021/jm00017a016
		10219796	9454	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	195	6	3	3	0.4	CCCCP(=O)(O)CC(O)CN	10.1021/jm00017a016
		CHEMBL111817	9454	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	195	6	3	3	0.4	CCCCP(=O)(O)CC(O)CN	10.1021/jm00017a016
		15134818	9544	2	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	180	6	3	3	-0.0	NCCCP(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL112291	9544	2	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	180	6	3	3	-0.0	NCCCP(=O)(O)CCCN	10.1021/jm00017a016
		58227082	124612	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	322	1	1	2	5.1	CS[C@H]1CCC2C3CC[C@H]4C[C@H](O)CC[C@]4(C)C3CC[C@@]21C	nan
		CHEMBL3640617	124612	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	322	1	1	2	5.1	CS[C@H]1CCC2C3CC[C@H]4C[C@H](O)CC[C@]4(C)C3CC[C@@]21C	nan
		10466077	9575	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	221	5	2	3	1.2	NCCCP(=O)(O)CC1CCCCO1	10.1021/jm00017a016
		CHEMBL112451	9575	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	221	5	2	3	1.2	NCCCP(=O)(O)CC1CCCCO1	10.1021/jm00017a016
		10082524	9889	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	0.8	NC[C@@H](O)CP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
		CHEMBL114288	9889	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	0.8	NC[C@@H](O)CP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
		9877609	110461	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	193	4	2	3	0.7	NCCCP(=O)(O)C1CCCO1	10.1021/jm00017a016
		CHEMBL324694	110461	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	193	4	2	3	0.7	NCCCP(=O)(O)C1CCCO1	10.1021/jm00017a016
		10219657	9627	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	177	5	2	2	1.0	NCCCP(=O)(O)CC1CC1	10.1021/jm00017a016
		CHEMBL112658	9627	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	177	5	2	2	1.0	NCCCP(=O)(O)CC1CC1	10.1021/jm00017a016
		9834206	96739	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	195	6	3	3	0.7	CCCCP(=O)(O)C(O)CCN	10.1021/jm00017a016
		CHEMBL264396	96739	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	195	6	3	3	0.7	CCCCP(=O)(O)C(O)CCN	10.1021/jm00017a016
		130021	9654	37	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	179	6	2	2	1.4	CCCCP(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL112797	9654	37	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	179	6	2	2	1.4	CCCCP(=O)(O)CCCN	10.1021/jm00017a016
		10058852	9529	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	207	4	2	3	1.1	NCCCP(=O)(O)C1CCCCO1	10.1021/jm00017a016
		CHEMBL112213	9529	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	207	4	2	3	1.1	NCCCP(=O)(O)C1CCCCO1	10.1021/jm00017a016
		130022	9561	38	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	219	5	2	2	2.2	NCCCP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		CHEMBL112362	9561	38	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	219	5	2	2	2.2	NCCCP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		10465678	169332	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	209	6	3	3	0.8	CCCCP(=O)(O)CC(C)(O)CN	10.1021/jm00017a016
		CHEMBL441821	169332	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	209	6	3	3	0.8	CCCCP(=O)(O)CC(C)(O)CN	10.1021/jm00017a016
		121956	9527	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	123	3	2	2	-0.2	NCCC[PH](=O)O	10.1021/jm00017a016
		CHEMBL112203	9527	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	123	3	2	2	-0.2	NCCC[PH](=O)O	10.1021/jm00017a016
		10354046	9488	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	5	3	3	1.2	NCC(O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		CHEMBL112019	9488	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	5	3	3	1.2	NCC(O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		10376775	9745	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	5	3	3	1.2	NC[C@H](O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		CHEMBL113435	9745	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	5	3	3	1.2	NC[C@H](O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		10398919	10004	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	0.8	NC[C@H](O)CP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
		CHEMBL114918	10004	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	0.8	NC[C@H](O)CP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
		15134810	9535	1	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	152	4	3	3	-0.5	NCCCP(=O)(O)CN	10.1021/jm00017a016
		CHEMBL112248	9535	1	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	152	4	3	3	-0.5	NCCCP(=O)(O)CN	10.1021/jm00017a016
		10243064	9563	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	233	5	2	3	1.4	NCC(=O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		CHEMBL112376	9563	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	233	5	2	3	1.4	NCC(=O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		10331452	110191	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	231	5	2	2	1.9	NCCCP(=O)(O)Cc1ccc(F)cc1	10.1021/jm00017a016
		CHEMBL323713	110191	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	231	5	2	2	1.9	NCCCP(=O)(O)Cc1ccc(F)cc1	10.1021/jm00017a016
		1070	895	12	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
		1090	895	12	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
		197584	895	12	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
		CHEMBL1213187	895	12	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
		10059083	9620	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	214	5	2	3	1.2	NCCCP(=O)(O)Cc1ccccn1	10.1021/jm00017a016
		CHEMBL112638	9620	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	214	5	2	3	1.2	NCCCP(=O)(O)Cc1ccccn1	10.1021/jm00017a016
		10084142	9725	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	263	4	3	3	1.4	CP(=O)(O)CC(O)(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
		CHEMBL113305	9725	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	263	4	3	3	1.4	CP(=O)(O)CC(O)(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
		5310935	9726	4	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	5	3	3	1.2	NC[C@@H](O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		CHEMBL113308	9726	4	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	5	3	3	1.2	NC[C@@H](O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		9882973	109212	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	305	7	3	3	2.6	CCCCP(=O)(O)CC(O)(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
		CHEMBL321688	109212	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	305	7	3	3	2.6	CCCCP(=O)(O)CC(O)(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
		9942295	109733	0	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	179	3	2	2	1.4	CC(C)(C)P(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL322965	109733	0	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	179	3	2	2	1.4	CC(C)(C)P(=O)(O)CCCN	10.1021/jm00017a016
		10105202	10073	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	0.8	NCC(O)CP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
		CHEMBL115354	10073	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	0.8	NCC(O)CP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
		10059688	163411	1	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	1.3	NCCCP(=O)(O)C(O)c1ccccc1	10.1021/jm00017a016
		CHEMBL419582	163411	1	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	1.3	NCCCP(=O)(O)C(O)c1ccccc1	10.1021/jm00017a016
		58227081	124613	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	440	3	1	4	5.5	CN(C)c1ccc([C@H]2C[C@@]3(C)C(CC[C@@H]3[N+](=O)[O-])C3CC[C@H]4C[C@](C)(O)CCC4C32)cc1	nan
		CHEMBL3640618	124613	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	440	3	1	4	5.5	CN(C)c1ccc([C@H]2C[C@@]3(C)C(CC[C@@H]3[N+](=O)[O-])C3CC[C@H]4C[C@](C)(O)CCC4C32)cc1	nan
		9813635	9861	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	247	4	2	2	2.3	CP(=O)(O)CC(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
		CHEMBL114128	9861	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	247	4	2	2	2.3	CP(=O)(O)CC(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
		1070	895	12	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
		1090	895	12	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
		197584	895	12	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
		CHEMBL1213187	895	12	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025

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Main reference

Ligand source activities (1 row/activity)