Biased Signaling Atlas

Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1067	8490	128	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	119	8490	128	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	1262	8490	128	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	5410	8490	128	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	6992099	8490	128	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	CHEMBL96	8490	128	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	DB02530	8490	128	None	-4	4	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	103	3	2	2	-0.2	NCCCC(=O)O	10.1021/jm7015842
	11701095	195486	2	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	161	1	2	2	0.9	CP(=O)(O)C1=CCC(N)C1	10.1021/jm7015842
	CHEMBL504482	195486	2	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	161	1	2	2	0.9	CP(=O)(O)C1=CCC(N)C1	10.1021/jm7015842
	24895101	178818	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	161	1	2	2	0.9	CP(=O)(O)C1=CC[C@H](N)C1	10.1021/jm7015842
	CHEMBL447171	178818	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	161	1	2	2	0.9	CP(=O)(O)C1=CC[C@H](N)C1	10.1021/jm7015842
	24895106	177671	1	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	161	1	2	2	0.9	CP(=O)(O)C1=CC[C@@H](N)C1	10.1021/jm7015842
	CHEMBL445449	177671	1	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp methodAgonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method	ChEMBL	161	1	2	2	0.9	CP(=O)(O)C1=CC[C@@H](N)C1	10.1021/jm7015842
	16686147	9076	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	141	3	2	2	-0.3	NC[C@H](CP(=O)O)F	None
	7705	9076	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	141	3	2	2	-0.3	NC[C@H](CP(=O)O)F	None
	CHEMBL448343	9076	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	141	3	2	2	-0.3	NC[C@H](CP(=O)O)F	None
	DB11920	9076	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	141	3	2	2	-0.3	NC[C@H](CP(=O)O)F	None
	1067	8490	128	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	119	8490	128	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	1262	8490	128	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	5410	8490	128	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	6992099	8490	128	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	CHEMBL96	8490	128	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	DB02530	8490	128	None	4	4	Rat	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	103	3	2	2	-0.2	NCCCC(=O)O	None
	1064	7356	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	3428	7356	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	44602	7356	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	6918881	7356	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	CHEMBL301742	7356	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	DB00181	7356	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	DB08891	7356	0	None	-	1	Rat	4.5	pIC50	=	4.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	213	4	2	2	1.9	NC[C@@H](c1ccc(cc1)Cl)CC(=O)O	9069281
	1069	7679	49	None	-	1	Rat	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	7650685
	1069	7679	49	None	-	1	Rat	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	9069281
	107699	7679	49	None	-	1	Rat	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	7650685
	107699	7679	49	None	-	1	Rat	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	9069281
	CHEMBL40157	7679	49	None	-	1	Rat	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	7650685
	CHEMBL40157	7679	49	None	-	1	Rat	4.7	pIC50	=	4.7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	9069281
	1081	6884	0	None	-	1	Rat	5.6	pIC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	122	3	2	2	0.1	NCCC[P+](=O)O	9069281
	5381	6884	0	None	-	1	Rat	5.6	pIC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	122	3	2	2	0.1	NCCC[P+](=O)O	9069281
	6335948	6884	0	None	-	1	Rat	5.6	pIC50	=	5.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	122	3	2	2	0.1	NCCC[P+](=O)O	9069281
	1075	10328	0	None	-	1	Rat	6.4	pIC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	2	2	3	0.2	OC(=O)C[C@@H]1OCC(NC1)(C)C	7562513
	5311429	10328	0	None	-	1	Rat	6.4	pIC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	2	2	3	0.2	OC(=O)C[C@@H]1OCC(NC1)(C)C	7562513
	86294992	10328	0	None	-	1	Rat	6.4	pIC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	2	2	3	0.2	OC(=O)C[C@@H]1OCC(NC1)(C)C	7562513
	CHEMBL1895916	10328	0	None	-	1	Rat	6.4	pIC50	=	6.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	2	2	3	0.2	OC(=O)C[C@@H]1OCC(NC1)(C)C	7562513
	1072	7684	0	None	-	1	Rat	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	421	10	3	5	3.2	COc1ccc(cc1)CP(=O)(C[C@H](CN([C@@H](c1cccc(c1)C(=O)O)C)C)O)O	9069281
	3429	7684	0	None	-	1	Rat	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	421	10	3	5	3.2	COc1ccc(cc1)CP(=O)(C[C@H](CN([C@@H](c1cccc(c1)C(=O)O)C)C)O)O	9069281
	5310936	7684	0	None	-	1	Rat	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	421	10	3	5	3.2	COc1ccc(cc1)CP(=O)(C[C@H](CN([C@@H](c1cccc(c1)C(=O)O)C)C)O)O	9069281
	1078	10231	0	None	-	1	Rat	3.5	pIC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	249	4	2	3	1.3	NCC(c1ccc(cc1)Cl)CS(=O)(=O)O	9069281
	122150	10231	0	None	-	1	Rat	3.5	pIC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	249	4	2	3	1.3	NCC(c1ccc(cc1)Cl)CS(=O)(=O)O	9069281
	CHEMBL312403	10231	0	None	-	1	Rat	3.5	pIC50	None	3.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	249	4	2	3	1.3	NCC(c1ccc(cc1)Cl)CS(=O)(=O)O	9069281
	1068	6856	0	None	-	1	Rat	4.1	pIC50	None	4.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	4	3	4	0.4	NCC(c1ccc(cc1)Cl)(CS(=O)(=O)O)O	9069281
	1564	6856	0	None	-	1	Rat	4.1	pIC50	None	4.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	4	3	4	0.4	NCC(c1ccc(cc1)Cl)(CS(=O)(=O)O)O	9069281
	CHEMBL1256573	6856	0	None	-	1	Rat	4.1	pIC50	None	4.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	265	4	3	4	0.4	NCC(c1ccc(cc1)Cl)(CS(=O)(=O)O)O	9069281
	1067	8490	128	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	119	8490	128	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	1262	8490	128	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	5410	8490	128	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	6992099	8490	128	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	CHEMBL96	8490	128	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	DB02530	8490	128	None	4	4	Rat	4.6	pIC50	None	4.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	103	3	2	2	-0.2	NCCCC(=O)O	9069281
	10154248	7681	0	None	-	1	Human	4.9	pIC50	None	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	4	2	2	0.8	NCCCP(=O)(C(F)F)O	9069281
	1066	7681	0	None	-	1	Human	4.9	pIC50	None	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	4	2	2	0.8	NCCCP(=O)(C(F)F)O	9069281
	CHEMBL113553	7681	0	None	-	1	Human	4.9	pIC50	None	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	173	4	2	2	0.8	NCCCP(=O)(C(F)F)O	9069281
	1074	7687	0	None	-	1	Rat	8.4	pIC50	None	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	659	15	6	7	4.5	[N-]=[N+]=Nc1cc(O)c(cc1I)C(=O)NCCCCCP(=O)(C[C@H](CN[C@@H](c1cccc(c1)C(=O)O)C)O)O	9069281
	6324595	7687	0	None	-	1	Rat	8.4	pIC50	None	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	659	15	6	7	4.5	[N-]=[N+]=Nc1cc(O)c(cc1I)C(=O)NCCCCCP(=O)(C[C@H](CN[C@@H](c1cccc(c1)C(=O)O)C)O)O	9069281
	CHEMBL1909011	7687	0	None	-	1	Rat	8.4	pIC50	None	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	659	15	6	7	4.5	[N-]=[N+]=Nc1cc(O)c(cc1I)C(=O)NCCCCCP(=O)(C[C@H](CN[C@@H](c1cccc(c1)C(=O)O)C)O)O	9069281
	1073	7685	0	None	-	1	Rat	8.6	pIC50	None	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	646	16	6	6	3.9	O=C(CCc1ccc(c(c1)I)O)NCCCCCP(=O)(C[C@H](CN[C@@H](c1cccc(c1)C(=O)O)C)O)O	9069281
	5311043	7685	0	None	-	1	Rat	8.6	pIC50	None	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	646	16	6	6	3.9	O=C(CCc1ccc(c(c1)I)O)NCCCCCP(=O)(C[C@H](CN[C@@H](c1cccc(c1)C(=O)O)C)O)O	9069281
	CHEMBL1909010	7685	0	None	-	1	Rat	8.6	pIC50	None	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	646	16	6	6	3.9	O=C(CCc1ccc(c(c1)I)O)NCCCCCP(=O)(C[C@H](CN[C@@H](c1cccc(c1)C(=O)O)C)O)O	9069281
	1070	7682	12	None	3	2	Rat	8.8	pIC50	None	8.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	9069281
	1090	7682	12	None	3	2	Rat	8.8	pIC50	None	8.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	9069281
	197584	7682	12	None	3	2	Rat	8.8	pIC50	None	8.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	9069281
	CHEMBL1213187	7682	12	None	3	2	Rat	8.8	pIC50	None	8.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	9069281
	1071	7683	0	None	-	1	Rat	9.2	pIC50	None	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	383	9	4	4	3.2	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@@H](c1cccc(c1)C(=O)O)C	9069281
	9800175	7683	0	None	-	1	Rat	9.2	pIC50	None	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	383	9	4	4	3.2	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@@H](c1cccc(c1)C(=O)O)C	9069281

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		2284	210852	114	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human GABBR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GABBR1 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	213	4	2	2	1.9	NCC(CC(=O)O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL701	210852	114	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human GABBR1 in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human GABBR1 in an in vitro assay with cellular components measured by scintillation proximity assay	ChEMBL	213	4	2	2	1.9	NCC(CC(=O)O)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		5446	8649	57	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Positive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibition of 7beta forskolin-stimulated cyclic AMP formation after 2 hrs in presence of 0.3 uM GABA relative to 100 uM GABA alonePositive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibition of 7beta forskolin-stimulated cyclic AMP formation after 2 hrs in presence of 0.3 uM GABA relative to 100 uM GABA alone	ChEMBL	337	6	2	7	3.8	CSc1nc(NC2CCCC2)c(c(n1)NC1CCCC1)[N+](=O)[O-]	10.1016/j.bmcl.2017.03.084
		6604928	8649	57	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Positive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibition of 7beta forskolin-stimulated cyclic AMP formation after 2 hrs in presence of 0.3 uM GABA relative to 100 uM GABA alonePositive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibition of 7beta forskolin-stimulated cyclic AMP formation after 2 hrs in presence of 0.3 uM GABA relative to 100 uM GABA alone	ChEMBL	337	6	2	7	3.8	CSc1nc(NC2CCCC2)c(c(n1)NC1CCCC1)[N+](=O)[O-]	10.1016/j.bmcl.2017.03.084
		CHEMBL392394	8649	57	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Positive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibition of 7beta forskolin-stimulated cyclic AMP formation after 2 hrs in presence of 0.3 uM GABA relative to 100 uM GABA alonePositive allosteric modulation at human GABA-B 1b expressed in CHO cells co-expressing rat GABA-B2 assessed as potentiation of GABA-induced inhibition of 7beta forskolin-stimulated cyclic AMP formation after 2 hrs in presence of 0.3 uM GABA relative to 100 uM GABA alone	ChEMBL	337	6	2	7	3.8	CSc1nc(NC2CCCC2)c(c(n1)NC1CCCC1)[N+](=O)[O-]	10.1016/j.bmcl.2017.03.084
		9964332	16814	0	None	-	0	Rat	6.0	pIC50	=	6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	193	6	2	3	0.6	CC(=O)CCP(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL115162	16814	0	None	-	0	Rat	6.0	pIC50	=	6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	193	6	2	3	0.6	CC(=O)CCP(=O)(O)CCCN	10.1021/jm00017a016
		9813169	16555	2	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	213	5	2	2	1.8	NCCCP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
		CHEMBL113613	16555	2	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	213	5	2	2	1.8	NCCCP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
		28560001	117182	8	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	227	6	2	2	1.8	NCCCP(=O)(O)CCc1ccccc1	10.1021/jm00017a016
		659968	117182	8	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	227	6	2	2	1.8	NCCCP(=O)(O)CCc1ccccc1	10.1021/jm00017a016
		CHEMBL324407	117182	8	None	-	0	Rat	5.0	pIC50	=	5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	227	6	2	2	1.8	NCCCP(=O)(O)CCc1ccccc1	10.1021/jm00017a016
		9883500	149107	1	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	318	1	1	2	4.6	CC(=O)[C@H]1CCC2C3CC[C@H]4C[C@H](O)CC[C@]4(C)C3CC[C@@]21C	nan
		CHEMBL38856	149107	1	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	318	1	1	2	4.6	CC(=O)[C@H]1CCC2C3CC[C@H]4C[C@H](O)CC[C@]4(C)C3CC[C@@]21C	nan
		10377028	115384	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	241	8	3	5	-0.1	CCOC(OCC)P(=O)(O)C[C@@H](O)CN	10.1021/jm00017a016
		CHEMBL320533	115384	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	241	8	3	5	-0.1	CCOC(OCC)P(=O)(O)C[C@@H](O)CN	10.1021/jm00017a016
		58227083	131388	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	321	1	1	3	4.0	C[C@]12CC[C@@H](O)C[C@@H]1CCC1C2CC[C@@]2(C)C1CC[C@@H]2[N+](=O)[O-]	nan
		CHEMBL3640615	131388	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	321	1	1	3	4.0	C[C@]12CC[C@@H](O)C[C@@H]1CCC1C2CC[C@@]2(C)C1CC[C@@H]2[N+](=O)[O-]	nan
		9920531	117098	2	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	179	5	2	2	1.3	CC(C)CP(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL323887	117098	2	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	179	5	2	2	1.3	CC(C)CP(=O)(O)CCCN	10.1021/jm00017a016
		10352529	117444	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	191	5	2	3	0.2	NCC(=O)CP(=O)(O)CC1CC1	10.1021/jm00017a016
		CHEMBL325932	117444	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	191	5	2	3	0.2	NCC(=O)CP(=O)(O)CC1CC1	10.1021/jm00017a016
		28559746	16411	55	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	137	3	2	2	0.2	CP(=O)(O)CCCN	10.1021/jm00017a016
		5230	16411	55	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	137	3	2	2	0.2	CP(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL112710	16411	55	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	137	3	2	2	0.2	CP(=O)(O)CCCN	10.1021/jm00017a016
		9920471	16235	3	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	165	5	2	2	1.0	CCCP(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL111890	16235	3	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	165	5	2	2	1.0	CCCP(=O)(O)CCCN	10.1021/jm00017a016
		9964768	117152	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	241	8	3	5	-0.1	CCOC(OCC)P(=O)(O)CC(O)CN	10.1021/jm00017a016
		CHEMBL324244	117152	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	241	8	3	5	-0.1	CCOC(OCC)P(=O)(O)CC(O)CN	10.1021/jm00017a016
		58227084	131389	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	335	1	1	3	4.4	C[C@]12CC[C@@](C)(O)C[C@@H]1CCC1C2CC[C@@]2(C)C1CC[C@@H]2[N+](=O)[O-]	nan
		CHEMBL3640616	131389	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	335	1	1	3	4.4	C[C@]12CC[C@@](C)(O)C[C@@H]1CCC1C2CC[C@@]2(C)C1CC[C@@H]2[N+](=O)[O-]	nan
		9815542	16344	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	195	6	3	3	0.7	CCCC(O)P(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL112408	16344	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	195	6	3	3	0.7	CCCC(O)P(=O)(O)CCCN	10.1021/jm00017a016
		9878233	118077	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	253	8	2	4	1.7	CC(C)OC(OC(C)C)P(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL326622	118077	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	253	8	2	4	1.7	CC(C)OC(OC(C)C)P(=O)(O)CCCN	10.1021/jm00017a016
		10105390	16349	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	233	6	2	2	2.6	NCCCP(=O)(O)CCC1CCCCC1	10.1021/jm00017a016
		CHEMBL112460	16349	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	233	6	2	2	2.6	NCCCP(=O)(O)CCC1CCCCC1	10.1021/jm00017a016
		10466591	16393	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	6	2	3	1.6	NCCCP(=O)(O)CCC1CCCCO1	10.1021/jm00017a016
		CHEMBL112639	16393	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	6	2	3	1.6	NCCCP(=O)(O)CCC1CCCCO1	10.1021/jm00017a016
		44341174	16542	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	343	9	5	5	-0.5	NCCCP(=O)(O)CC(O)CNC(=O)c1ccccc1C(N)=O	10.1021/jm00017a016
		CHEMBL113540	16542	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	343	9	5	5	-0.5	NCCCP(=O)(O)CC(O)CNC(=O)c1ccccc1C(N)=O	10.1021/jm00017a016
		9898878	117442	21	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	151	4	2	2	0.6	CCP(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL325921	117442	21	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	151	4	2	2	0.6	CCP(=O)(O)CCCN	10.1021/jm00017a016
		130023	16548	9	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	207	8	2	2	2.2	CCCCCCP(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL113571	16548	9	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	207	8	2	2	2.2	CCCCCCP(=O)(O)CCCN	10.1021/jm00017a016
		9878836	16898	2	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	281	12	2	4	2.5	CCCCOC(OCCCC)P(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL115664	16898	2	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	281	12	2	4	2.5	CCCCOC(OCCCC)P(=O)(O)CCCN	10.1021/jm00017a016
		9923821	16754	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	335	9	2	4	3.0	CCOC(OCC)P(=O)(O)CC(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
		CHEMBL114812	16754	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	335	9	2	4	3.0	CCOC(OCC)P(=O)(O)CC(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
		9877786	16417	1	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	215	6	2	2	2.0	CCCC(F)(F)P(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL112741	16417	1	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	215	6	2	2	2.0	CCCC(F)(F)P(=O)(O)CCCN	10.1021/jm00017a016
		1069	7679	49	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	10.1021/jm00017a016
		107699	7679	49	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	10.1021/jm00017a016
		CHEMBL40157	7679	49	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	225	8	2	4	1.0	NCCCP(=O)(C(OCC)OCC)O	10.1021/jm00017a016
		9856380	16611	2	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	253	10	2	4	1.7	CCCOC(OCCC)P(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL114027	16611	2	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	253	10	2	4	1.7	CCCOC(OCCC)P(=O)(O)CCCN	10.1021/jm00017a016
		10219796	16226	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	195	6	3	3	0.4	CCCCP(=O)(O)CC(O)CN	10.1021/jm00017a016
		CHEMBL111817	16226	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	195	6	3	3	0.4	CCCCP(=O)(O)CC(O)CN	10.1021/jm00017a016
		15134818	16316	2	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	180	6	3	3	-0.0	NCCCP(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL112291	16316	2	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	180	6	3	3	-0.0	NCCCP(=O)(O)CCCN	10.1021/jm00017a016
		58227082	131390	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	322	1	1	2	5.1	CS[C@H]1CCC2C3CC[C@H]4C[C@H](O)CC[C@]4(C)C3CC[C@@]21C	nan
		CHEMBL3640617	131390	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	322	1	1	2	5.1	CS[C@H]1CCC2C3CC[C@H]4C[C@H](O)CC[C@]4(C)C3CC[C@@]21C	nan
		10466077	16347	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	221	5	2	3	1.2	NCCCP(=O)(O)CC1CCCCO1	10.1021/jm00017a016
		CHEMBL112451	16347	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	221	5	2	3	1.2	NCCCP(=O)(O)CC1CCCCO1	10.1021/jm00017a016
		10082524	16661	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	0.8	NC[C@@H](O)CP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
		CHEMBL114288	16661	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	0.8	NC[C@@H](O)CP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
		9877609	117238	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	193	4	2	3	0.7	NCCCP(=O)(O)C1CCCO1	10.1021/jm00017a016
		CHEMBL324694	117238	0	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	193	4	2	3	0.7	NCCCP(=O)(O)C1CCCO1	10.1021/jm00017a016
		10219657	16399	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	177	5	2	2	1.0	NCCCP(=O)(O)CC1CC1	10.1021/jm00017a016
		CHEMBL112658	16399	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	177	5	2	2	1.0	NCCCP(=O)(O)CC1CC1	10.1021/jm00017a016
		9834206	103514	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	195	6	3	3	0.7	CCCCP(=O)(O)C(O)CCN	10.1021/jm00017a016
		CHEMBL264396	103514	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	195	6	3	3	0.7	CCCCP(=O)(O)C(O)CCN	10.1021/jm00017a016
		130021	16426	37	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	179	6	2	2	1.4	CCCCP(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL112797	16426	37	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	179	6	2	2	1.4	CCCCP(=O)(O)CCCN	10.1021/jm00017a016
		10058852	16301	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	207	4	2	3	1.1	NCCCP(=O)(O)C1CCCCO1	10.1021/jm00017a016
		CHEMBL112213	16301	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	207	4	2	3	1.1	NCCCP(=O)(O)C1CCCCO1	10.1021/jm00017a016
		130022	16333	38	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	219	5	2	2	2.2	NCCCP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		CHEMBL112362	16333	38	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	219	5	2	2	2.2	NCCCP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		10465678	176111	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	209	6	3	3	0.8	CCCCP(=O)(O)CC(C)(O)CN	10.1021/jm00017a016
		CHEMBL441821	176111	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	209	6	3	3	0.8	CCCCP(=O)(O)CC(C)(O)CN	10.1021/jm00017a016
		121956	16299	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	123	3	2	2	-0.2	NCCC[PH](=O)O	10.1021/jm00017a016
		CHEMBL112203	16299	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	123	3	2	2	-0.2	NCCC[PH](=O)O	10.1021/jm00017a016
		10354046	16260	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	5	3	3	1.2	NCC(O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		CHEMBL112019	16260	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	5	3	3	1.2	NCC(O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		10376775	16517	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	5	3	3	1.2	NC[C@H](O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		CHEMBL113435	16517	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	5	3	3	1.2	NC[C@H](O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		10398919	16776	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	0.8	NC[C@H](O)CP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
		CHEMBL114918	16776	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	0.8	NC[C@H](O)CP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
		15134810	16307	1	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	152	4	3	3	-0.5	NCCCP(=O)(O)CN	10.1021/jm00017a016
		CHEMBL112248	16307	1	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	152	4	3	3	-0.5	NCCCP(=O)(O)CN	10.1021/jm00017a016
		10243064	16335	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	233	5	2	3	1.4	NCC(=O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		CHEMBL112376	16335	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	233	5	2	3	1.4	NCC(=O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		10331452	116968	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	231	5	2	2	1.9	NCCCP(=O)(O)Cc1ccc(F)cc1	10.1021/jm00017a016
		CHEMBL323713	116968	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	231	5	2	2	1.9	NCCCP(=O)(O)Cc1ccc(F)cc1	10.1021/jm00017a016
		1070	7682	12	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
		1090	7682	12	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
		197584	7682	12	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
		CHEMBL1213187	7682	12	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
		10059083	16392	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	214	5	2	3	1.2	NCCCP(=O)(O)Cc1ccccn1	10.1021/jm00017a016
		CHEMBL112638	16392	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	214	5	2	3	1.2	NCCCP(=O)(O)Cc1ccccn1	10.1021/jm00017a016
		10084142	16497	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	263	4	3	3	1.4	CP(=O)(O)CC(O)(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
		CHEMBL113305	16497	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	263	4	3	3	1.4	CP(=O)(O)CC(O)(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
		5310935	16498	4	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	5	3	3	1.2	NC[C@@H](O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		CHEMBL113308	16498	4	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	235	5	3	3	1.2	NC[C@@H](O)CP(=O)(O)CC1CCCCC1	10.1021/jm00017a016
		9882973	115989	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	305	7	3	3	2.6	CCCCP(=O)(O)CC(O)(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
		CHEMBL321688	115989	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	305	7	3	3	2.6	CCCCP(=O)(O)CC(O)(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
		9942295	116510	0	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	179	3	2	2	1.4	CC(C)(C)P(=O)(O)CCCN	10.1021/jm00017a016
		CHEMBL322965	116510	0	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	179	3	2	2	1.4	CC(C)(C)P(=O)(O)CCCN	10.1021/jm00017a016
		10105202	16845	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	0.8	NCC(O)CP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
		CHEMBL115354	16845	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	0.8	NCC(O)CP(=O)(O)Cc1ccccc1	10.1021/jm00017a016
		10059688	170190	1	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	1.3	NCCCP(=O)(O)C(O)c1ccccc1	10.1021/jm00017a016
		CHEMBL419582	170190	1	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	229	5	3	3	1.3	NCCCP(=O)(O)C(O)c1ccccc1	10.1021/jm00017a016
		58227081	131391	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	440	3	1	4	5.5	CN(C)c1ccc([C@H]2C[C@@]3(C)C(CC[C@@H]3[N+](=O)[O-])C3CC[C@H]4C[C@](C)(O)CCC4C32)cc1	nan
		CHEMBL3640618	131391	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding Assay: [35S]TBPS binding assay.Binding Assay: [35S]TBPS binding assay.	ChEMBL	440	3	1	4	5.5	CN(C)c1ccc([C@H]2C[C@@]3(C)C(CC[C@@H]3[N+](=O)[O-])C3CC[C@H]4C[C@](C)(O)CCC4C32)cc1	nan
		9813635	16633	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	247	4	2	2	2.3	CP(=O)(O)CC(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
		CHEMBL114128	16633	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex.	ChEMBL	247	4	2	2	2.3	CP(=O)(O)CC(CN)c1ccc(Cl)cc1	10.1021/jm00017a016
		1070	7682	12	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
		1090	7682	12	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
		197584	7682	12	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025
		CHEMBL1213187	7682	12	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrsDisplacement of [3H]CGP54626 from human recombinant GABAB1A receptor expressed in CHO cells after 3 hrs	ChEMBL	407	8	3	3	4.9	O[C@H](CP(=O)(CC1CCCCC1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C	10.1016/j.bmcl.2013.01.025

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Main reference

Ligand source activities (1 row/activity)