Ligand source activities (1 row/activity)
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
102331684 | 122031 | 0 | None | - | 1 | Mouse | 4.1 | pEC50 | = | 4.1 | Functional | ChEMBL | 186 | 4 | 5 | 3 | -1.3 | N=C(N)NCC[C@H]1C[C@@]1(N)C(=O)O | 10.1039/C1MD00186H | ||
CHEMBL3347673 | 122031 | 0 | None | - | 1 | Mouse | 4.1 | pEC50 | = | 4.1 | Functional | ChEMBL | 186 | 4 | 5 | 3 | -1.3 | N=C(N)NCC[C@H]1C[C@@]1(N)C(=O)O | 10.1039/C1MD00186H | ||
8693156 | 130886 | 1 | None | - | 1 | Mouse | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 409 | 6 | 1 | 4 | 2.9 | CN(CC(=O)c1c(-c2ccc(F)cc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
CHEMBL3633655 | 130886 | 1 | None | - | 1 | Mouse | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 409 | 6 | 1 | 4 | 2.9 | CN(CC(=O)c1c(-c2ccc(F)cc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
8693156 | 130886 | 1 | None | - | 1 | Mouse | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 409 | 6 | 1 | 4 | 2.9 | CN(CC(=O)c1c(-c2ccc(F)cc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
CHEMBL3633655 | 130886 | 1 | None | - | 1 | Mouse | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 409 | 6 | 1 | 4 | 2.9 | CN(CC(=O)c1c(-c2ccc(F)cc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
9044803 | 130883 | 11 | None | 1 | 2 | Mouse | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 391 | 6 | 1 | 4 | 2.8 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
CHEMBL3633650 | 130883 | 11 | None | 1 | 2 | Mouse | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 391 | 6 | 1 | 4 | 2.8 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
9044803 | 130883 | 11 | None | 1 | 2 | Mouse | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 391 | 6 | 1 | 4 | 2.8 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
CHEMBL3633650 | 130883 | 11 | None | 1 | 2 | Mouse | 4.7 | pIC50 | = | 4.7 | Functional | ChEMBL | 391 | 6 | 1 | 4 | 2.8 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
122195442 | 130884 | 0 | None | - | 1 | Mouse | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 409 | 6 | 1 | 4 | 2.9 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccc(F)cc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
CHEMBL3633651 | 130884 | 0 | None | - | 1 | Mouse | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 409 | 6 | 1 | 4 | 2.9 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccc(F)cc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
122195442 | 130884 | 0 | None | - | 1 | Mouse | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 409 | 6 | 1 | 4 | 2.9 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccc(F)cc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
CHEMBL3633651 | 130884 | 0 | None | - | 1 | Mouse | 4.4 | pIC50 | = | 4.4 | Functional | ChEMBL | 409 | 6 | 1 | 4 | 2.9 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccc(F)cc12)CC(=O)N1CCOCC1 | 10.1021/acs.jmedchem.5b01254 | ||
122195453 | 130888 | 0 | None | 2 | 2 | Mouse | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 431 | 5 | 1 | 4 | 3.6 | O=C(CN1CCCC(C(=O)N2CCOCC2)C1)c1c(-c2ccccc2)[nH]c2ccccc12 | 10.1021/acs.jmedchem.5b01254 | ||
CHEMBL3633663 | 130888 | 0 | None | 2 | 2 | Mouse | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 431 | 5 | 1 | 4 | 3.6 | O=C(CN1CCCC(C(=O)N2CCOCC2)C1)c1c(-c2ccccc2)[nH]c2ccccc12 | 10.1021/acs.jmedchem.5b01254 | ||
122195453 | 130888 | 0 | None | 2 | 2 | Mouse | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 431 | 5 | 1 | 4 | 3.6 | O=C(CN1CCCC(C(=O)N2CCOCC2)C1)c1c(-c2ccccc2)[nH]c2ccccc12 | 10.1021/acs.jmedchem.5b01254 | ||
CHEMBL3633663 | 130888 | 0 | None | 2 | 2 | Mouse | 5.3 | pIC50 | = | 5.3 | Functional | ChEMBL | 431 | 5 | 1 | 4 | 3.6 | O=C(CN1CCCC(C(=O)N2CCOCC2)C1)c1c(-c2ccccc2)[nH]c2ccccc12 | 10.1021/acs.jmedchem.5b01254 | ||
17521846 | 130889 | 4 | None | - | 1 | Mouse | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 375 | 6 | 1 | 3 | 3.6 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCCC1 | 10.1021/acs.jmedchem.5b01254 | ||
CHEMBL3633664 | 130889 | 4 | None | - | 1 | Mouse | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 375 | 6 | 1 | 3 | 3.6 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCCC1 | 10.1021/acs.jmedchem.5b01254 | ||
17521846 | 130889 | 4 | None | - | 1 | Mouse | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 375 | 6 | 1 | 3 | 3.6 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCCC1 | 10.1021/acs.jmedchem.5b01254 | ||
CHEMBL3633664 | 130889 | 4 | None | - | 1 | Mouse | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 375 | 6 | 1 | 3 | 3.6 | CN(CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12)CC(=O)N1CCCC1 | 10.1021/acs.jmedchem.5b01254 | ||
122195454 | 130890 | 0 | None | 8 | 2 | Mouse | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 377 | 7 | 1 | 4 | 3.3 | CN(CCN1CCOCC1)CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12 | 10.1021/acs.jmedchem.5b01254 | ||
CHEMBL3633665 | 130890 | 0 | None | 8 | 2 | Mouse | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 377 | 7 | 1 | 4 | 3.3 | CN(CCN1CCOCC1)CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12 | 10.1021/acs.jmedchem.5b01254 | ||
122195454 | 130890 | 0 | None | 8 | 2 | Mouse | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 377 | 7 | 1 | 4 | 3.3 | CN(CCN1CCOCC1)CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12 | 10.1021/acs.jmedchem.5b01254 | ||
CHEMBL3633665 | 130890 | 0 | None | 8 | 2 | Mouse | 5.2 | pIC50 | = | 5.2 | Functional | ChEMBL | 377 | 7 | 1 | 4 | 3.3 | CN(CCN1CCOCC1)CC(=O)c1c(-c2ccccc2)[nH]c2ccccc12 | 10.1021/acs.jmedchem.5b01254 | ||
122195445 | 130885 | 0 | None | - | 1 | Mouse | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 421 | 7 | 1 | 5 | 2.8 | COc1ccc2[nH]c(-c3ccccc3)c(C(=O)CN(C)CC(=O)N3CCOCC3)c2c1 | 10.1021/acs.jmedchem.5b01254 | ||
CHEMBL3633654 | 130885 | 0 | None | - | 1 | Mouse | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 421 | 7 | 1 | 5 | 2.8 | COc1ccc2[nH]c(-c3ccccc3)c(C(=O)CN(C)CC(=O)N3CCOCC3)c2c1 | 10.1021/acs.jmedchem.5b01254 | ||
122195445 | 130885 | 0 | None | - | 1 | Mouse | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 421 | 7 | 1 | 5 | 2.8 | COc1ccc2[nH]c(-c3ccccc3)c(C(=O)CN(C)CC(=O)N3CCOCC3)c2c1 | 10.1021/acs.jmedchem.5b01254 | ||
CHEMBL3633654 | 130885 | 0 | None | - | 1 | Mouse | 4.2 | pIC50 | = | 4.2 | Functional | ChEMBL | 421 | 7 | 1 | 5 | 2.8 | COc1ccc2[nH]c(-c3ccccc3)c(C(=O)CN(C)CC(=O)N3CCOCC3)c2c1 | 10.1021/acs.jmedchem.5b01254 | ||
122195446 | 130887 | 0 | None | 1 | 5 | Mouse | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 421 | 7 | 1 | 5 | 2.8 | COc1ccc(-c2[nH]c3ccccc3c2C(=O)CN(C)CC(=O)N2CCOCC2)cc1 | 10.1021/acs.jmedchem.5b01254 | ||
CHEMBL3633656 | 130887 | 0 | None | 1 | 5 | Mouse | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 421 | 7 | 1 | 5 | 2.8 | COc1ccc(-c2[nH]c3ccccc3c2C(=O)CN(C)CC(=O)N2CCOCC2)cc1 | 10.1021/acs.jmedchem.5b01254 | ||
122195446 | 130887 | 0 | None | 1 | 5 | Mouse | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 421 | 7 | 1 | 5 | 2.8 | COc1ccc(-c2[nH]c3ccccc3c2C(=O)CN(C)CC(=O)N2CCOCC2)cc1 | 10.1021/acs.jmedchem.5b01254 | ||
CHEMBL3633656 | 130887 | 0 | None | 1 | 5 | Mouse | 5.0 | pIC50 | = | 5.0 | Functional | ChEMBL | 421 | 7 | 1 | 5 | 2.8 | COc1ccc(-c2[nH]c3ccccc3c2C(=O)CN(C)CC(=O)N2CCOCC2)cc1 | 10.1021/acs.jmedchem.5b01254 | ||
3401 | 9125 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Drug Central | 132 | 4 | 3 | 3 | -0.9 | N[C@H](C(=O)O)CCCN | None | ||
6262 | 9125 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Drug Central | 132 | 4 | 3 | 3 | -0.9 | N[C@H](C(=O)O)CCCN | None | ||
725 | 9125 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Drug Central | 132 | 4 | 3 | 3 | -0.9 | N[C@H](C(=O)O)CCCN | None | ||
88747248 | 9125 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Drug Central | 132 | 4 | 3 | 3 | -0.9 | N[C@H](C(=O)O)CCCN | None | ||
CHEMBL446143 | 9125 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Drug Central | 132 | 4 | 3 | 3 | -0.9 | N[C@H](C(=O)O)CCCN | None | ||
DB00129 | 9125 | 0 | None | - | 1 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Drug Central | 132 | 4 | 3 | 3 | -0.9 | N[C@H](C(=O)O)CCCN | None | ||
1549 | 9059 | 111 | None | -1 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Drug Central | 174 | 5 | 4 | 3 | -1.5 | OC(=O)[C@H](CCCN=C(N)N)N | None | ||
28782 | 9059 | 111 | None | -1 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Drug Central | 174 | 5 | 4 | 3 | -1.5 | OC(=O)[C@H](CCCN=C(N)N)N | None | ||
6322 | 9059 | 111 | None | -1 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Drug Central | 174 | 5 | 4 | 3 | -1.5 | OC(=O)[C@H](CCCN=C(N)N)N | None | ||
721 | 9059 | 111 | None | -1 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Drug Central | 174 | 5 | 4 | 3 | -1.5 | OC(=O)[C@H](CCCN=C(N)N)N | None | ||
CHEMBL1485 | 9059 | 111 | None | -1 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Drug Central | 174 | 5 | 4 | 3 | -1.5 | OC(=O)[C@H](CCCN=C(N)N)N | None | ||
DB00125 | 9059 | 111 | None | -1 | 3 | Human | 8.4 | pEC50 | = | 8.4 | Functional | Drug Central | 174 | 5 | 4 | 3 | -1.5 | OC(=O)[C@H](CCCN=C(N)N)N | None | ||
1311 | 9096 | 0 | None | - | 1 | Human | 3.2 | pEC50 | None | 3.2 | Functional | Guide to Pharmacology | 146 | 4 | 3 | 3 | -1.3 | NC(=O)CC[C@@H](C(=O)O)N | 15576628 | ||
4633 | 9096 | 0 | None | - | 1 | Human | 3.2 | pEC50 | None | 3.2 | Functional | Guide to Pharmacology | 146 | 4 | 3 | 3 | -1.3 | NC(=O)CC[C@@H](C(=O)O)N | 15576628 | ||
4634 | 9096 | 0 | None | - | 1 | Human | 3.2 | pEC50 | None | 3.2 | Functional | Guide to Pharmacology | 146 | 4 | 3 | 3 | -1.3 | NC(=O)CC[C@@H](C(=O)O)N | 15576628 | ||
5961 | 9096 | 0 | None | - | 1 | Human | 3.2 | pEC50 | None | 3.2 | Functional | Guide to Pharmacology | 146 | 4 | 3 | 3 | -1.3 | NC(=O)CC[C@@H](C(=O)O)N | 15576628 | ||
6992086 | 9096 | 0 | None | - | 1 | Human | 3.2 | pEC50 | None | 3.2 | Functional | Guide to Pharmacology | 146 | 4 | 3 | 3 | -1.3 | NC(=O)CC[C@@H](C(=O)O)N | 15576628 | ||
723 | 9096 | 0 | None | - | 1 | Human | 3.2 | pEC50 | None | 3.2 | Functional | Guide to Pharmacology | 146 | 4 | 3 | 3 | -1.3 | NC(=O)CC[C@@H](C(=O)O)N | 15576628 | ||
CHEMBL930 | 9096 | 0 | None | - | 1 | Human | 3.2 | pEC50 | None | 3.2 | Functional | Guide to Pharmacology | 146 | 4 | 3 | 3 | -1.3 | NC(=O)CC[C@@H](C(=O)O)N | 15576628 | ||
DB00130 | 9096 | 0 | None | - | 1 | Human | 3.2 | pEC50 | None | 3.2 | Functional | Guide to Pharmacology | 146 | 4 | 3 | 3 | -1.3 | NC(=O)CC[C@@H](C(=O)O)N | 15576628 | ||
4127 | 9139 | 117 | None | -1348 | 2 | Human | 3.2 | pEC50 | None | 3.2 | Functional | Guide to Pharmacology | 105 | 2 | 3 | 3 | -1.6 | OC[C@@H](C(=O)O)N | 15576628 | ||
5951 | 9139 | 117 | None | -1348 | 2 | Human | 3.2 | pEC50 | None | 3.2 | Functional | Guide to Pharmacology | 105 | 2 | 3 | 3 | -1.6 | OC[C@@H](C(=O)O)N | 15576628 | ||
6857581 | 9139 | 117 | None | -1348 | 2 | Human | 3.2 | pEC50 | None | 3.2 | Functional | Guide to Pharmacology | 105 | 2 | 3 | 3 | -1.6 | OC[C@@H](C(=O)O)N | 15576628 | ||
726 | 9139 | 117 | None | -1348 | 2 | Human | 3.2 | pEC50 | None | 3.2 | Functional | Guide to Pharmacology | 105 | 2 | 3 | 3 | -1.6 | OC[C@@H](C(=O)O)N | 15576628 | ||
CHEMBL11298 | 9139 | 117 | None | -1348 | 2 | Human | 3.2 | pEC50 | None | 3.2 | Functional | Guide to Pharmacology | 105 | 2 | 3 | 3 | -1.6 | OC[C@@H](C(=O)O)N | 15576628 | ||
DB00133 | 9139 | 117 | None | -1348 | 2 | Human | 3.2 | pEC50 | None | 3.2 | Functional | Guide to Pharmacology | 105 | 2 | 3 | 3 | -1.6 | OC[C@@H](C(=O)O)N | 15576628 | ||
1319 | 8607 | 130 | None | -12302 | 2 | Human | 3.6 | pEC50 | None | 3.6 | Functional | Guide to Pharmacology | 75 | 1 | 2 | 2 | -1.0 | NCC(=O)O | 15576628 | ||
4084 | 8607 | 130 | None | -12302 | 2 | Human | 3.6 | pEC50 | None | 3.6 | Functional | Guide to Pharmacology | 75 | 1 | 2 | 2 | -1.0 | NCC(=O)O | 15576628 | ||
4635 | 8607 | 130 | None | -12302 | 2 | Human | 3.6 | pEC50 | None | 3.6 | Functional | Guide to Pharmacology | 75 | 1 | 2 | 2 | -1.0 | NCC(=O)O | 15576628 | ||
5257127 | 8607 | 130 | None | -12302 | 2 | Human | 3.6 | pEC50 | None | 3.6 | Functional | Guide to Pharmacology | 75 | 1 | 2 | 2 | -1.0 | NCC(=O)O | 15576628 | ||
727 | 8607 | 130 | None | -12302 | 2 | Human | 3.6 | pEC50 | None | 3.6 | Functional | Guide to Pharmacology | 75 | 1 | 2 | 2 | -1.0 | NCC(=O)O | 15576628 | ||
750 | 8607 | 130 | None | -12302 | 2 | Human | 3.6 | pEC50 | None | 3.6 | Functional | Guide to Pharmacology | 75 | 1 | 2 | 2 | -1.0 | NCC(=O)O | 15576628 | ||
CHEMBL773 | 8607 | 130 | None | -12302 | 2 | Human | 3.6 | pEC50 | None | 3.6 | Functional | Guide to Pharmacology | 75 | 1 | 2 | 2 | -1.0 | NCC(=O)O | 15576628 | ||
DB00145 | 8607 | 130 | None | -12302 | 2 | Human | 3.6 | pEC50 | None | 3.6 | Functional | Guide to Pharmacology | 75 | 1 | 2 | 2 | -1.0 | NCC(=O)O | 15576628 | ||
3103 | 9071 | 0 | None | - | 1 | Human | 3.6 | pEC50 | None | 3.6 | Functional | Guide to Pharmacology | 175 | 5 | 4 | 3 | -1.2 | NC(=O)NCCC[C@@H](C(=O)O)N | 15576628 | ||
6992098 | 9071 | 0 | None | - | 1 | Human | 3.6 | pEC50 | None | 3.6 | Functional | Guide to Pharmacology | 175 | 5 | 4 | 3 | -1.2 | NC(=O)NCCC[C@@H](C(=O)O)N | 15576628 | ||
722 | 9071 | 0 | None | - | 1 | Human | 3.6 | pEC50 | None | 3.6 | Functional | Guide to Pharmacology | 175 | 5 | 4 | 3 | -1.2 | NC(=O)NCCC[C@@H](C(=O)O)N | 15576628 | ||
9750 | 9071 | 0 | None | - | 1 | Human | 3.6 | pEC50 | None | 3.6 | Functional | Guide to Pharmacology | 175 | 5 | 4 | 3 | -1.2 | NC(=O)NCCC[C@@H](C(=O)O)N | 15576628 | ||
CHEMBL444814 | 9071 | 0 | None | - | 1 | Human | 3.6 | pEC50 | None | 3.6 | Functional | Guide to Pharmacology | 175 | 5 | 4 | 3 | -1.2 | NC(=O)NCCC[C@@H](C(=O)O)N | 15576628 | ||
DB00155 | 9071 | 0 | None | - | 1 | Human | 3.6 | pEC50 | None | 3.6 | Functional | Guide to Pharmacology | 175 | 5 | 4 | 3 | -1.2 | NC(=O)NCCC[C@@H](C(=O)O)N | 15576628 | ||
4255 | 9050 | 0 | None | - | 1 | Human | 3.8 | pEC50 | None | 3.8 | Functional | Guide to Pharmacology | 89 | 1 | 2 | 2 | -0.6 | C[C@@H](C(=O)O)N | 15576628 | ||
4542 | 9050 | 0 | None | - | 1 | Human | 3.8 | pEC50 | None | 3.8 | Functional | Guide to Pharmacology | 89 | 1 | 2 | 2 | -0.6 | C[C@@H](C(=O)O)N | 15576628 | ||
4543 | 9050 | 0 | None | - | 1 | Human | 3.8 | pEC50 | None | 3.8 | Functional | Guide to Pharmacology | 89 | 1 | 2 | 2 | -0.6 | C[C@@H](C(=O)O)N | 15576628 | ||
5950 | 9050 | 0 | None | - | 1 | Human | 3.8 | pEC50 | None | 3.8 | Functional | Guide to Pharmacology | 89 | 1 | 2 | 2 | -0.6 | C[C@@H](C(=O)O)N | 15576628 | ||
720 | 9050 | 0 | None | - | 1 | Human | 3.8 | pEC50 | None | 3.8 | Functional | Guide to Pharmacology | 89 | 1 | 2 | 2 | -0.6 | C[C@@H](C(=O)O)N | 15576628 | ||
7311724 | 9050 | 0 | None | - | 1 | Human | 3.8 | pEC50 | None | 3.8 | Functional | Guide to Pharmacology | 89 | 1 | 2 | 2 | -0.6 | C[C@@H](C(=O)O)N | 15576628 | ||
CHEMBL279597 | 9050 | 0 | None | - | 1 | Human | 3.8 | pEC50 | None | 3.8 | Functional | Guide to Pharmacology | 89 | 1 | 2 | 2 | -0.6 | C[C@@H](C(=O)O)N | 15576628 | ||
DB00160 | 9050 | 0 | None | - | 1 | Human | 3.8 | pEC50 | None | 3.8 | Functional | Guide to Pharmacology | 89 | 1 | 2 | 2 | -0.6 | C[C@@H](C(=O)O)N | 15576628 | ||
122198194 | 9117 | 0 | None | - | 1 | Human | 3.8 | pEC50 | None | 3.8 | Functional | Guide to Pharmacology | 146 | 5 | 3 | 3 | -0.5 | NCCCC[C@@H](C(=O)O)N | 15576628 | ||
1622 | 9117 | 0 | None | - | 1 | Human | 3.8 | pEC50 | None | 3.8 | Functional | Guide to Pharmacology | 146 | 5 | 3 | 3 | -0.5 | NCCCC[C@@H](C(=O)O)N | 15576628 | ||
5962 | 9117 | 0 | None | - | 1 | Human | 3.8 | pEC50 | None | 3.8 | Functional | Guide to Pharmacology | 146 | 5 | 3 | 3 | -0.5 | NCCCC[C@@H](C(=O)O)N | 15576628 | ||
71774817 | 9117 | 0 | None | - | 1 | Human | 3.8 | pEC50 | None | 3.8 | Functional | Guide to Pharmacology | 146 | 5 | 3 | 3 | -0.5 | NCCCC[C@@H](C(=O)O)N | 15576628 | ||
724 | 9117 | 0 | None | - | 1 | Human | 3.8 | pEC50 | None | 3.8 | Functional | Guide to Pharmacology | 146 | 5 | 3 | 3 | -0.5 | NCCCC[C@@H](C(=O)O)N | 15576628 | ||
CHEMBL8085 | 9117 | 0 | None | - | 1 | Human | 3.8 | pEC50 | None | 3.8 | Functional | Guide to Pharmacology | 146 | 5 | 3 | 3 | -0.5 | NCCCC[C@@H](C(=O)O)N | 15576628 | ||
DB00123 | 9117 | 0 | None | - | 1 | Human | 3.8 | pEC50 | None | 3.8 | Functional | Guide to Pharmacology | 146 | 5 | 3 | 3 | -0.5 | NCCCC[C@@H](C(=O)O)N | 15576628 | ||
3401 | 9125 | 0 | None | - | 1 | Human | 4.0 | pEC50 | None | 4 | Functional | Guide to Pharmacology | 132 | 4 | 3 | 3 | -0.9 | N[C@H](C(=O)O)CCCN | 15576628 | ||
6262 | 9125 | 0 | None | - | 1 | Human | 4.0 | pEC50 | None | 4 | Functional | Guide to Pharmacology | 132 | 4 | 3 | 3 | -0.9 | N[C@H](C(=O)O)CCCN | 15576628 | ||
725 | 9125 | 0 | None | - | 1 | Human | 4.0 | pEC50 | None | 4 | Functional | Guide to Pharmacology | 132 | 4 | 3 | 3 | -0.9 | N[C@H](C(=O)O)CCCN | 15576628 | ||
88747248 | 9125 | 0 | None | - | 1 | Human | 4.0 | pEC50 | None | 4 | Functional | Guide to Pharmacology | 132 | 4 | 3 | 3 | -0.9 | N[C@H](C(=O)O)CCCN | 15576628 | ||
CHEMBL446143 | 9125 | 0 | None | - | 1 | Human | 4.0 | pEC50 | None | 4 | Functional | Guide to Pharmacology | 132 | 4 | 3 | 3 | -0.9 | N[C@H](C(=O)O)CCCN | 15576628 | ||
DB00129 | 9125 | 0 | None | - | 1 | Human | 4.0 | pEC50 | None | 4 | Functional | Guide to Pharmacology | 132 | 4 | 3 | 3 | -0.9 | N[C@H](C(=O)O)CCCN | 15576628 | ||
1549 | 9059 | 111 | None | -1 | 3 | Human | 4.4 | pEC50 | None | 4.4 | Functional | Guide to Pharmacology | 174 | 5 | 4 | 3 | -1.5 | OC(=O)[C@H](CCCN=C(N)N)N | 15576628 | ||
28782 | 9059 | 111 | None | -1 | 3 | Human | 4.4 | pEC50 | None | 4.4 | Functional | Guide to Pharmacology | 174 | 5 | 4 | 3 | -1.5 | OC(=O)[C@H](CCCN=C(N)N)N | 15576628 | ||
6322 | 9059 | 111 | None | -1 | 3 | Human | 4.4 | pEC50 | None | 4.4 | Functional | Guide to Pharmacology | 174 | 5 | 4 | 3 | -1.5 | OC(=O)[C@H](CCCN=C(N)N)N | 15576628 | ||
721 | 9059 | 111 | None | -1 | 3 | Human | 4.4 | pEC50 | None | 4.4 | Functional | Guide to Pharmacology | 174 | 5 | 4 | 3 | -1.5 | OC(=O)[C@H](CCCN=C(N)N)N | 15576628 | ||
CHEMBL1485 | 9059 | 111 | None | -1 | 3 | Human | 4.4 | pEC50 | None | 4.4 | Functional | Guide to Pharmacology | 174 | 5 | 4 | 3 | -1.5 | OC(=O)[C@H](CCCN=C(N)N)N | 15576628 | ||
DB00125 | 9059 | 111 | None | -1 | 3 | Human | 4.4 | pEC50 | None | 4.4 | Functional | Guide to Pharmacology | 174 | 5 | 4 | 3 | -1.5 | OC(=O)[C@H](CCCN=C(N)N)N | 15576628 | ||
719 | 7571 | 5 | None | -27 | 3 | Mouse | 5.0 | pIC50 | ~ | 5 | Functional | Guide to Pharmacology | 300 | 4 | 2 | 1 | 5.2 | C[C@H](c1cccc2c1cccc2)NCc1cc2c([nH]1)cccc2 | 19836834 | ||
9882793 | 7571 | 5 | None | -27 | 3 | Mouse | 5.0 | pIC50 | ~ | 5 | Functional | Guide to Pharmacology | 300 | 4 | 2 | 1 | 5.2 | C[C@H](c1cccc2c1cccc2)NCc1cc2c([nH]1)cccc2 | 19836834 | ||
CHEMBL1801356 | 7571 | 5 | None | -27 | 3 | Mouse | 5.0 | pIC50 | ~ | 5 | Functional | Guide to Pharmacology | 300 | 4 | 2 | 1 | 5.2 | C[C@H](c1cccc2c1cccc2)NCc1cc2c([nH]1)cccc2 | 19836834 | ||
6918446 | 9654 | 56 | None | -616 | 6 | Mouse | 5.0 | pIC50 | ~ | 5 | Functional | Guide to Pharmacology | 408 | 8 | 2 | 4 | 4.7 | N#Cc1c(cccc1Cl)OC[C@@H](CNC(Cc1ccc2c(c1)cccc2)(C)C)O | 19836834 | ||
716 | 9654 | 56 | None | -616 | 6 | Mouse | 5.0 | pIC50 | ~ | 5 | Functional | Guide to Pharmacology | 408 | 8 | 2 | 4 | 4.7 | N#Cc1c(cccc1Cl)OC[C@@H](CNC(Cc1ccc2c(c1)cccc2)(C)C)O | 19836834 | ||
CHEMBL180672 | 9654 | 56 | None | -616 | 6 | Mouse | 5.0 | pIC50 | ~ | 5 | Functional | Guide to Pharmacology | 408 | 8 | 2 | 4 | 4.7 | N#Cc1c(cccc1Cl)OC[C@@H](CNC(Cc1ccc2c(c1)cccc2)(C)C)O | 19836834 | ||
DB05695 | 9654 | 56 | None | -616 | 6 | Mouse | 5.0 | pIC50 | ~ | 5 | Functional | Guide to Pharmacology | 408 | 8 | 2 | 4 | 4.7 | N#Cc1c(cccc1Cl)OC[C@@H](CNC(Cc1ccc2c(c1)cccc2)(C)C)O | 19836834 |
Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
102331684 | 122031 | 0 | None | - | 1 | Mouse | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 186 | 4 | 5 | 3 | -1.3 | N=C(N)NCC[C@H]1C[C@@]1(N)C(=O)O | 10.1039/C1MD00186H | |||
CHEMBL3347673 | 122031 | 0 | None | - | 1 | Mouse | 4.1 | pKi | = | 4.1 | Binding | ChEMBL | 186 | 4 | 5 | 3 | -1.3 | N=C(N)NCC[C@H]1C[C@@]1(N)C(=O)O | 10.1039/C1MD00186H |