Ligand source activities (1 row/activity)





Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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name
GPCRdb
ID
#Vendors

Reference
ligand
Fold
selectivity
# Tested
GPCRs
Species

p-value
(-log)
Activity
Type
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Activity
Value
AssayType

Assay
Description
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Mol
weight
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Bonds
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LogP

Smiles

DOI





Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
Sel. page Similar-
ity
Common
name
GPCRdb
ID
#Vendors

Reference
ligand
Fold
selectivity
# Tested
GPCRs
Species

p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Assay
Type
Assay
Description
Source

Mol
weight
Rot
Bonds
H don

H acc

LogP

Smiles

DOI

10327 10232 65 None - 1 Human 5.6 pKd = 5.6 Binding
Determined in a displacement NanoBRET assay using BODIPY–cyclopamine and nanoluciferase (Nluc)-tagged FZD<sub>6</sub>, in cells with CRISPR/Cas9 disabled SMO expression.Determined in a displacement NanoBRET assay using BODIPY–cyclopamine and nanoluciferase (Nluc)-tagged FZD<sub>6</sub>, in cells with CRISPR/Cas9 disabled SMO expression.
Guide to Pharmacology 489 6 1 4 6.8 CNC1CCC(CC1)N(C(=O)c1sc2c(c1Cl)cccc2)Cc1cccc(c1)c1ccncc1 31964872
5284330 10232 65 None - 1 Human 5.6 pKd = 5.6 Binding
Determined in a displacement NanoBRET assay using BODIPY–cyclopamine and nanoluciferase (Nluc)-tagged FZD<sub>6</sub>, in cells with CRISPR/Cas9 disabled SMO expression.Determined in a displacement NanoBRET assay using BODIPY–cyclopamine and nanoluciferase (Nluc)-tagged FZD<sub>6</sub>, in cells with CRISPR/Cas9 disabled SMO expression.
Guide to Pharmacology 489 6 1 4 6.8 CNC1CCC(CC1)N(C(=O)c1sc2c(c1Cl)cccc2)Cc1cccc(c1)c1ccncc1 31964872
CHEMBL1221983 10232 65 None - 1 Human 5.6 pKd = 5.6 Binding
Determined in a displacement NanoBRET assay using BODIPY–cyclopamine and nanoluciferase (Nluc)-tagged FZD<sub>6</sub>, in cells with CRISPR/Cas9 disabled SMO expression.Determined in a displacement NanoBRET assay using BODIPY–cyclopamine and nanoluciferase (Nluc)-tagged FZD<sub>6</sub>, in cells with CRISPR/Cas9 disabled SMO expression.
Guide to Pharmacology 489 6 1 4 6.8 CNC1CCC(CC1)N(C(=O)c1sc2c(c1Cl)cccc2)Cc1cccc(c1)c1ccncc1 31964872