Ligand source activities (1 row/activity)





Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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DOI

10197 10744 0 None -14 5 Human 8.0 pIC50 ~ 8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 22753465




Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
Sel. page Similar-
ity
Common
name
GPCRdb
ID
#Vendors

Reference
ligand
Fold
selectivity
# Tested
GPCRs
Species

p-value
(-log)
Activity
Type
Activity
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Activity
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weight
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DOI

2554 7583 119 None -81 8 Mouse 4.8 pKd = 4.8 Binding
Binding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assayBinding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assay
ChEMBL 236 0 1 1 3.4 NC(=O)N1c2ccccc2C=Cc2c1cccc2 10.1021/acs.jmedchem.9b02020
489 7583 119 None -81 8 Mouse 4.8 pKd = 4.8 Binding
Binding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assayBinding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assay
ChEMBL 236 0 1 1 3.4 NC(=O)N1c2ccccc2C=Cc2c1cccc2 10.1021/acs.jmedchem.9b02020
5339 7583 119 None -81 8 Mouse 4.8 pKd = 4.8 Binding
Binding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assayBinding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assay
ChEMBL 236 0 1 1 3.4 NC(=O)N1c2ccccc2C=Cc2c1cccc2 10.1021/acs.jmedchem.9b02020
CHEMBL108 7583 119 None -81 8 Mouse 4.8 pKd = 4.8 Binding
Binding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assayBinding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assay
ChEMBL 236 0 1 1 3.4 NC(=O)N1c2ccccc2C=Cc2c1cccc2 10.1021/acs.jmedchem.9b02020
DB00564 7583 119 None -81 8 Mouse 4.8 pKd = 4.8 Binding
Binding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assayBinding affinity to immobilized mouse C-terminal Rhinovirus 3C cleavage site-fused 6xHis-tagged Frizzled-8 CRD (Q33 to G173 resideus) transfected with pDisplay_BirA-ER plasmid in HEK293T cells for biotinylation by surface plasmon resonance assay
ChEMBL 236 0 1 1 3.4 NC(=O)N1c2ccccc2C=Cc2c1cccc2 10.1021/acs.jmedchem.9b02020
2554 7583 119 None -1 8 Human 8.3 pKd = 8.3 Binding
Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.
Drug Central 236 0 1 1 3.4 NC(=O)N1c2ccccc2C=Cc2c1cccc2 None
489 7583 119 None -1 8 Human 8.3 pKd = 8.3 Binding
Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.
Drug Central 236 0 1 1 3.4 NC(=O)N1c2ccccc2C=Cc2c1cccc2 None
5339 7583 119 None -1 8 Human 8.3 pKd = 8.3 Binding
Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.
Drug Central 236 0 1 1 3.4 NC(=O)N1c2ccccc2C=Cc2c1cccc2 None
CHEMBL108 7583 119 None -1 8 Human 8.3 pKd = 8.3 Binding
Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.
Drug Central 236 0 1 1 3.4 NC(=O)N1c2ccccc2C=Cc2c1cccc2 None
DB00564 7583 119 None -1 8 Human 8.3 pKd = 8.3 Binding
Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.
Drug Central 236 0 1 1 3.4 NC(=O)N1c2ccccc2C=Cc2c1cccc2 None
2554 7583 119 None -1 8 Human 4.8 pKd = 4.8 Binding
Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.
Guide to Pharmacology 236 0 1 1 3.4 NC(=O)N1c2ccccc2C=Cc2c1cccc2 32049522
489 7583 119 None -1 8 Human 4.8 pKd = 4.8 Binding
Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.
Guide to Pharmacology 236 0 1 1 3.4 NC(=O)N1c2ccccc2C=Cc2c1cccc2 32049522
5339 7583 119 None -1 8 Human 4.8 pKd = 4.8 Binding
Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.
Guide to Pharmacology 236 0 1 1 3.4 NC(=O)N1c2ccccc2C=Cc2c1cccc2 32049522
CHEMBL108 7583 119 None -1 8 Human 4.8 pKd = 4.8 Binding
Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.
Guide to Pharmacology 236 0 1 1 3.4 NC(=O)N1c2ccccc2C=Cc2c1cccc2 32049522
DB00564 7583 119 None -1 8 Human 4.8 pKd = 4.8 Binding
Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.Binding affinity for FZD8 cysteine-rich domain (CRD) by SPR analysis.
Guide to Pharmacology 236 0 1 1 3.4 NC(=O)N1c2ccccc2C=Cc2c1cccc2 32049522