Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
acthr_human 2.54x54 74 TM2 S => I N/A N/A Weber A et al (1993)
acthr_human 7.28x27 251 TM7 C => F N/A N/A Naville D et al (1996)
acthr_human 3.29x29 107 TM3 D => N N/A N/A Naville D et al (1996)
acthr_human 1.53x53 45 TM1 V => I N/A N/A Naville D et al (1996)
acthr_human 7.28x27 251 TM7 C => F N/A N/A Naville D et al (1996)
acthr_human 3.29x29 107 TM3 D => N N/A N/A Naville D et al (1996)
acthr_human 21 N-term C => R N/A N/A Elias LL et al (1999)
acthr_human 21 N-term C => R N/A N/A Swords FM et al (2004)
acthr_human 1.52x52 44 TM1 I => M N/A N/A Elias LL et al (1999)
acthr_human 2.54x54 74 TM2 S => I N/A N/A Elias LL et al (1999)
acthr_human 2.54x54 74 TM2 S => I N/A N/A Weber A et al (1993)
acthr_human 3.25x25 103 TM3 D => N N/A N/A Elias LL et al (1999)
acthr_human 3.29x29 107 TM3 D => N N/A N/A Naville D et al (1996)
acthr_human 3.50x50 128 TM3 R => C N/A N/A Elias LL et al (1999)
acthr_human 4.41x41 146 TM4 R => H N/A N/A Elias LL et al (1999)
acthr_human 4.54x54 159 TM4 T => K N/A N/A Elias LL et al (1999)
acthr_human 247 ECL3 S => G N/A N/A Elias LL et al (1999)
acthr_human 247 ECL3 S => G N/A N/A Swords FM et al (2004)
acthr_human 7.28x27 251 TM7 C => F N/A N/A Naville D et al (1996)
acthr_human 7.28x27 251 TM7 C => F N/A N/A Naville D et al (1996)
acthr_human 3.38x38 116 TM3 G => V N/A N/A Chung TT et al (2008)
acthr_human 3.51x51 129 TM3 Y => C N/A N/A Chung TT et al (2008)
acthr_human 2.54x54 74 TM2 S => I N/A N/A Chung TT et al (2008)
acthr_human 6.42x42 226 TM6 G => R N/A N/A Chung TT et al (2008)
acthr_human 34.52x52 137 ICL2 R => W N/A N/A Chung TT et al (2008)
acthr_human 4.54x54 159 TM4 T => K N/A N/A Chung TT et al (2008)
acthr_human 1.52x52 44 TM1 I => M N/A N/A Chung TT et al (2008)
acthr_human 7.31x30 254 TM7 Y => C N/A N/A Chung TT et al (2008)
acthr_human 3.25x25 103 TM3 D => N N/A N/A Chung TT et al (2008)
acthr_human 7.28x27 251 TM7 C => F N/A N/A Chung TT et al (2008)
acthr_human 4.41x41 146 TM4 R => H N/A N/A Chung TT et al (2008)
acthr_human 3.52x52 130 TM3 I => N N/A N/A Chung TT et al (2008)
acthr_human 4.47x47 152 TM4 T => K N/A N/A Chung TT et al (2008)
acthr_human 20 N-term D => N N/A N/A Chung TT et al (2008)
acthr_human 170 ECL2 H => L N/A N/A Chung TT et al (2008)
acthr_human 3.50x50 128 TM3 R => C N/A N/A Chung TT et al (2008)
acthr_human 3.29x29 107 TM3 D => N N/A N/A Chung TT et al (2008)
acthr_human 12.50x50 55 ICL1 L => P N/A N/A Chung TT et al (2008)
acthr_human 247 ECL3 S => G N/A N/A Swords FM et al (2004)
acthr_human 2.70x70 90 TM2 G => D N/A N/A Swords FM et al (2004)
acthr_human 21 N-term C => R N/A N/A Swords FM et al (2004)
acthr_human 4.41x41 146 TM4 R => H N/A N/A Lin L et al (2007)
acthr_human 7.30x29 253 TM7 C => S N/A N/A Yang Y et al (2007)
acthr_human 2.54x54 74 TM2 S => I N/A N/A Lin L et al (2007)
acthr_human 6.61x61 245 TM6 C => S N/A N/A Yang Y et al (2007)
acthr_human 7.28x27 251 TM7 C => S N/A N/A Yang Y et al (2007)
acthr_human 5.56x56 191 TM5 C => S N/A N/A Yang Y et al (2007)
acthr_human 21 N-term C => S N/A N/A Yang Y et al (2007)
acthr_human 3.50x50 128 TM3 R => C N/A N/A Chan LF et al (2009)
acthr_human 21 N-term C => R N/A N/A Chan LF et al (2009)
acthr_human 247 ECL3 S => G N/A N/A Chan LF et al (2009)
acthr_human 6.47x47 231 TM6 C => S N/A N/A Yang Y et al (2007)
acthr_human 4.53x53 158 TM4 C => S N/A N/A Yang Y et al (2007)
acthr_human 2.44x44 64 TM2 C => S N/A N/A Yang Y et al (2007)
acthr_human 8.60x60 293 H8 C => S N/A N/A Yang Y et al (2007)
acthr_human 7.44x43 267 TM7 C => S N/A N/A Yang Y et al (2007)
acthr_human 3.19x19 97 TM3 S => I N/A N/A Hughes CR et al (2010)
acthr_human 3.48x48 126 TM3 A => S N/A N/A Artigas RA et al (2008)
acthr_human 7.55x55 278 TM7 F => C N/A N/A Chan LF et al (2009)
acthr_human 3.51x51 129 TM3 Y => C N/A N/A Chan LF et al (2009)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 K N L Q ICL1ECL1 Y L K P R ECL1ICL2 A L R Y H S I V ICL2ECL2 H ECL2ICL3 T L P R A ICL3ECL3 P S ECL3N-term M K H I I N S Y E N I N N T A R N N S D C P R V V L N-termC-term R Y W C-term P E E I F F T I S I V G V L E N L I V L L A V F K N A P M Y F F I C S L A I S D M L G S L Y K I L E N I L I I L R N M G G S F E T T A D D I I D S L F V L S L L G S I F S L S V I A A D R Y I T I F H T M R R T V V V L T V I W T F C T G T G I T M V I F S H V P T V I T F T S L F P L M L V F I L C L Y V H M F L L A R S H T R K I S N M K G A I T L T I L L G V F I F C W A P F V L H V L L M T F C N P Y C A C Y M S L F Q V N G M L I M C N A V I D P F I Y A F R S P E F K K S L R D A M I F C
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
L N E L V G V I S I T F F I E E P 1 C S L A I S D M L G S L Y K I L E N I L 2 V S L S F I S G L L S L V F L S D I I D 3 T V V V L T V I W T F C T G T G I T M V 4 Y L C L I F V L M L P F L S T F T I V T 5 T I L L G V F I F C W A P F V L H V L L 6 F P D I V A N C M I L M G N V Q F L S 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
MC2 receptor
TM1
1x52 1.52x52 I44
1x53 1.53x53 V45
TM2
2x44 2.44x44 C64
2x54 2.54x54 S74
2x70 2.70x70 G90
TM3
3x19 3.19x19 S97
3x25 3.25x25 D103
3x29 3.29x29 D107
3x38 3.38x38 G116
3x48 3.48x48 A126
3x50 3.50x50 R128
3x51 3.51x51 Y129
3x52 3.52x52 I130
TM4
4x41 4.41x41 R146
4x47 4.47x47 T152
4x53 4.53x53 C158
4x54 4.54x54 T159
TM5
5x56 5.56x56 C191
TM6
6x42 6.42x42 G226
6x47 6.47x47 C231
6x61 6.61x61 C245
TM7
7x27 7.28x27 C251
7x29 7.30x29 C253
7x30 7.31x30 Y254
7x43 7.44x43 C267
7x55 7.55x55 F278
H8
8x60 8.60x60 C293