Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
brs3_human 6.58x58 294 TM6 H => R N/A N/A Sainz E et al (1998)
brs3_human 3.32x32 127 TM3 R => Q N/A N/A Sainz E et al (1998)
brs3_human 13 N-term L => C N/A N/A Ryan RR et al (1998)
brs3_human 3.32x32 127 TM3 R => Q N/A N/A Jian X et al (1999)
brs3_human 3.32x32 127 TM3 R => Q N/A N/A Akeson M et al (1997)
brs3_human 3.32x32 127 TM3 R => Q N/A N/A Sainz E et al (1998)
brs3_human 45.52x52 205 ECL2 S => P N/A N/A Jian X et al (1999)
brs3_human 45.52x52 205 ECL2 S => P N/A N/A Akeson M et al (1997)
brs3_human 45.52x52 205 ECL2 S => P N/A N/A Sainz E et al (1998)
brs3_human 6.58x58 294 TM6 H => R N/A N/A Jian X et al (1999)
brs3_human 6.58x58 294 TM6 H => R N/A N/A Akeson M et al (1997)
brs3_human 6.58x58 294 TM6 H => R N/A N/A Sainz E et al (1998)
brs3_human 7.38x37 315 TM7 S => A N/A N/A Jian X et al (1999)
brs3_human 7.38x37 315 TM7 S => A N/A N/A Akeson M et al (1997)
brs3_human 7.38x37 315 TM7 S => A N/A N/A Sainz E et al (1998)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 K S M Q ICL1ECL1 E G W L F ECL1ICL2 P L E R Q P S N ICL2ECL2 N V Y T F R D P N K N M T F E S C T S Y P V S ECL2ICL3 P T E E Q S ICL3ECL3 Q T Y V D P ECL3N-term M A Q R Q P H S P N Q T L I S I T N D T E S S S S V V S N D N T N K G W S G D N S P G N-termC-term C C K A E R P E P P V A D T S L T T L A V M G T V P G T G S I Q M S E I S V T S F T G C S V K Q A E D R F C-term I E A L C A I Y I T Y A V I I S V G I L G N A I L I K V F F K T T V P N I F I T S L A F G D L L L L L T C V P V D A T H Y L A G R I G C K V L S F I R L T S V G V S V F T L T I L S A D R Y K A V V K A I L K T C V K A G C V W I V S M I F A L P E A I F S K K L L Q E I H S L L C F L V F Y I I P L S I I S V Y Y S L I A R T L Y K S T L N I H A R K Q I E S R K R I A R T V L V L V A L F A L C W L P N H L L Y L Y H S F T S S A M H F I F T I F S R V L A F S N S C V N P F A L Y W L S K S F K A F Q K H Q L F
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
A N G L I G V S I I V A Y T I Y I A C L 1 T S L A F G D L L L L T L C V P V D A T H 2 I T L T F V S V G V S T L R I F S L V K 3 T C V K A G C V W I V S M I F A L P E 4 Y Y V S I I S L P I I Y F V L F C L L S H 5 L V L V A L F A L C W L P N H L L Y L Y 6 F P N V C S N S F A L V R S F I T F I 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
BB3 receptor
TM3
3x32 3.32x32 R127
TM6
6x58 6.58x58 H294
TM7
7x37 7.38x37 S315