Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
ccr1_human 7.43x42 291 TM7 Y => A 55.556↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 7.39x38 287 TM7 E => Q 34.483↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 6.56x56 260 TM6 L => A 5.814↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 6.55x55 259 TM6 I => A >1000.0↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 6.51x51 255 TM6 Y => A Abolished IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 5.46x461 207 TM5 G => A Abolished IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 5.42x43 203 TM5 L => A Abolished IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 4.60x61 168 TM4 G => A Abolished IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 3.33x33 114 TM3 Y => A 500.0↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 3.32x32 113 TM3 Y => F 45.455↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 3.32x32 113 TM3 Y => A >1000.0↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 3.29x29 110 TM3 S => A Abolished IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 3.28x28 109 TM3 L => A Abolished IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 2.61x61 91 TM2 I => A 83.333↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 2.57x57 87 TM2 L => A Abolished IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 2.56x56 86 TM2 T => A 38.462↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 1.39x39 41 TM1 Y => A 26.316↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 1.38x38 40 TM1 L => A Abolished IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 7.43x42 291 TM7 Y => Q ~95.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 7.39x38 287 TM7 E => Q ~40.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 6.58x58 262 TM6 S => A ~95.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 6.55x55 259 TM6 I => A ~80.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 6.51x51 255 TM6 Y => A ~60.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 6.48x48 252 TM6 W => A ~80.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 5.47x47 208 TM5 L => A ~100.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 5.46x461 207 TM5 G => A ~100.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 5.42x43 203 TM5 L => A ~100.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 4.60x61 168 TM4 G => A ~100.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 4.57x57 165 TM4 S => A ~98.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 4.52x52 160 TM4 L => A ~100.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 3.39x39 120 TM3 E => Q ~90.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 3.38x38 119 TM3 S => A ~80.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 3.37x37 118 TM3 Y => A Abolished Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 3.34x34 115 TM3 T => A ~100.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 3.33x33 114 TM3 Y => A ~100.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 3.32x32 113 TM3 Y => A ~20.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 3.30x30 111 TM3 G => A ~100.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 3.28x28 109 TM3 L => A ~80.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 3.24x24 105 TM3 M => A ~98.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 2.64x64 94 TM2 K => A ~90.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 2.62x62 92 TM2 D => N ~85.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 2.61x61 91 TM2 I => A ~60.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 2.60x60 90 TM2 W => A ~80.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 2.57x57 87 TM2 L => A Abolished Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 2.56x56 86 TM2 T => A ~50.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 2.50x50 80 TM2 D => N ~100.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 1.42x42 44 TM1 V => A ~100.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 1.39x39 41 TM1 Y => A ~10.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 1.38x38 40 TM1 L => A ~100.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 1.35x35 37 TM1 L => A ~90.0↑ Single-point (Binding - Radioligand competition/displacement) UCB-35625 de Mendonca FL et al (2005) De Keyzer ELR et al (2026)
ccr1_human 3.32x32 113 TM3 Y => A >1000.0↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 6.55x55 259 TM6 I => A >1000.0↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 3.33x33 114 TM3 Y => A 500.0↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 2.61x61 91 TM2 I => A 83.333↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 7.43x42 291 TM7 Y => A 55.556↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 3.32x32 113 TM3 Y => F 45.455↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 2.56x56 86 TM2 T => A 34.483↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 7.39x38 287 TM7 E => Q 34.483↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 1.39x39 41 TM1 Y => A 26.316↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 6.56x56 260 TM6 L => A 5.814↓ IC50 (Binding - Radioligand competition/displacement) BX 471 Vaidehi N et al (2006) De Keyzer ELR et al (2026)
ccr1_human 1.39x39 41 TM1 Y => A N/A N/A de Mendonca FL et al (2005)
ccr1_human 2.50x50 80 TM2 D => N N/A N/A de Mendonca FL et al (2005)
ccr1_human 2.56x56 86 TM2 T => A N/A N/A de Mendonca FL et al (2005)
ccr1_human 2.57x57 87 TM2 L => A N/A N/A de Mendonca FL et al (2005)
ccr1_human 2.62x62 92 TM2 D => N N/A N/A de Mendonca FL et al (2005)
ccr1_human 3.32x32 113 TM3 Y => A N/A N/A de Mendonca FL et al (2005)
ccr1_human 3.37x37 118 TM3 Y => A N/A N/A de Mendonca FL et al (2005)
ccr1_human 3.39x39 120 TM3 E => Q N/A N/A de Mendonca FL et al (2005)
ccr1_human 4.41x41 149 TM4 F => N N/A N/A Zoffmann S et al (2002)
ccr1_human 5.44x45 205 TM5 L => G N/A N/A Zoffmann S et al (2002)
ccr1_human 7.39x38 287 TM7 E => A N/A N/A de Mendonca FL et al (2005)
ccr1_human 7.39x38 287 TM7 E => Q N/A N/A de Mendonca FL et al (2005)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 K R L K ICL1ECL1 D W V F ECL1ICL2 A V F A L R A R ICL2ECL2 K T Q W E F T H H T C S L H F P H E ECL2ICL3 R P ICL3ECL3 T H ECL3N-term M E T P N T T E D Y D T T T E F D Y G D A T P C Q N-termC-term R V A V H L V K W L P F L S V D R L E R V S S T S P S T G E H E L S A G F C-term K V N E R A F G A Q L L P P L Y S L V F V I G L V G N I L V V L V L V Q Y N M T S I Y L L N L A I S D L L F L F T L P F W I D Y K L K D G D A M C K I L S G F Y Y T G L Y S E I F F I I L L T I D R Y L A I V H T V T F G V I T S I I I W A L A I L A S M P G L Y F S S L R E W K L F Q A L K L N L F G L V L P L L V M I I C Y T G I I K I L L R N E K K S K A V R L I F V I M I I F F L F W T P Y N L T I L I S V F Q D F L F E C E Q S R H L D L A V Q V T E V I A Y T H C C V N P V I Y A F V G E R L R Q F R K Y L F H R
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
I N G V L G I V F V L S Y L P P L L Q A 1 L N L A I S D L L F L F T L P F W I D Y 2 L I I F F I E S Y L G T Y Y F G S L I K 3 G V I T S I I I W A L A I L A S M P G 4 Y C I I M V L L P L V L G F L N L K L A Q 5 F V I M I I F F L F W T P Y N L T I L I 6 V P N V C C H T Y A I V E T V Q V A L 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCR1
TM1
1x35 1.35x35 L37
1x38 1.38x38 L40
1x39 1.39x39 Y41
1x42 1.42x42 V44
TM2
2x50 2.50x50 D80
2x56 2.56x56 T86
2x57 2.57x57 L87
2x60 2.60x60 W90
2x61 2.61x61 I91
2x62 2.62x62 D92
2x64 2.64x64 K94
TM3
3x24 3.24x24 M105
3x28 3.28x28 L109
3x29 3.29x29 S110
3x30 3.30x30 G111
3x32 3.32x32 Y113
3x33 3.33x33 Y114
3x34 3.34x34 T115
3x37 3.37x37 Y118
3x38 3.38x38 S119
3x39 3.39x39 E120
TM4
4x41 4.41x41 F149
4x52 4.52x52 L160
4x57 4.57x57 S165
4x61 4.60x61 G168
TM5
5x43 5.42x43 L203
5x45 5.44x45 L205
5x461 5.46x461 G207
5x47 5.47x47 L208
TM6
6x48 6.48x48 W252
6x51 6.51x51 Y255
6x55 6.55x55 I259
6x56 6.56x56 L260
6x58 6.58x58 S262
TM7
7x38 7.39x38 E287
7x42 7.43x42 Y291