A2A receptor (aa2ar_human)
FAMILY
Class A (Rhodopsin) Nucleotide receptors Adenosine receptors A2A receptor
GENE
ADORA2A
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Adenosine receptor A2a
SOURCE
SWISSPROT
SEQUENCE
| TM1 | |||||||||
|
M
|
P
|
I
|
M
|
G
|
S
|
S
|
V
|
Y
|
I
|
| 10 | |||||||||
|
T
|
V
|
E
|
L
|
A
|
I
|
A
|
V
|
L
|
A
|
| 20 | |||||||||
|
I
|
L
|
G
|
N
|
V
|
L
|
V
|
C
|
W
|
A
|
| 30 | |||||||||
| ICL1 | |||||||||
|
V
|
W
|
L
|
N
|
S
|
N
|
L
|
Q
|
N
|
V
|
| 40 | |||||||||
| TM2 | |||||||||
|
T
|
N
|
Y
|
F
|
V
|
V
|
S
|
L
|
A
|
A
|
| 50 | |||||||||
|
A
|
D
|
I
|
A
|
V
|
G
|
V
|
L
|
A
|
I
|
| 60 | |||||||||
|
P
|
F
|
A
|
I
|
T
|
I
|
S
|
T
|
G
|
F
|
| 70 | |||||||||
| ECL1 | TM3 | ||||||||
|
C
|
A
|
A
|
C
|
H
|
G
|
C
|
L
|
F
|
I
|
| 80 | |||||||||
|
A
|
C
|
F
|
V
|
L
|
V
|
L
|
T
|
Q
|
S
|
| 90 | |||||||||
|
S
|
I
|
F
|
S
|
L
|
L
|
A
|
I
|
A
|
I
|
| 100 | |||||||||
|
D
|
R
|
Y
|
I
|
A
|
I
|
R
|
I
|
P
|
L
|
| 110 | |||||||||
| ICL2 | TM4 | ||||||||
|
R
|
Y
|
N
|
G
|
L
|
V
|
T
|
G
|
T
|
R
|
| 120 | |||||||||
|
A
|
K
|
G
|
I
|
I
|
A
|
I
|
C
|
W
|
V
|
| 130 | |||||||||
|
L
|
S
|
F
|
A
|
I
|
G
|
L
|
T
|
P
|
M
|
| 140 | |||||||||
| ECL2 | |||||||||
|
L
|
G
|
W
|
N
|
N
|
C
|
G
|
Q
|
P
|
K
|
| 150 | |||||||||
|
E
|
G
|
K
|
N
|
H
|
S
|
Q
|
G
|
C
|
G
|
| 160 | |||||||||
|
E
|
G
|
Q
|
V
|
A
|
C
|
L
|
F
|
E
|
D
|
| 170 | |||||||||
| TM5 | |||||||||
|
V
|
V
|
P
|
M
|
N
|
Y
|
M
|
V
|
Y
|
F
|
| 180 | |||||||||
|
N
|
F
|
F
|
A
|
C
|
V
|
L
|
V
|
P
|
L
|
| 190 | |||||||||
|
L
|
L
|
M
|
L
|
G
|
V
|
Y
|
L
|
R
|
I
|
| 200 | |||||||||
|
F
|
L
|
A
|
A
|
R
|
R
|
Q
|
L
|
K
|
Q
|
| 210 | |||||||||
| ICL3 | |||||||||
|
M
|
E
|
S
|
Q
|
P
|
L
|
P
|
G
|
E
|
R
|
| 220 | |||||||||
| TM6 | |||||||||
|
A
|
R
|
S
|
T
|
L
|
Q
|
K
|
E
|
V
|
H
|
| 230 | |||||||||
|
A
|
A
|
K
|
S
|
L
|
A
|
I
|
I
|
V
|
G
|
| 240 | |||||||||
|
L
|
F
|
A
|
L
|
C
|
W
|
L
|
P
|
L
|
H
|
| 250 | |||||||||
|
I
|
I
|
N
|
C
|
F
|
T
|
F
|
F
|
C
|
P
|
| 260 | |||||||||
| ECL3 | TM7 | ||||||||
|
D
|
C
|
S
|
H
|
A
|
P
|
L
|
W
|
L
|
M
|
| 270 | |||||||||
|
Y
|
L
|
A
|
I
|
V
|
L
|
S
|
H
|
T
|
N
|
| 280 | |||||||||
|
S
|
V
|
V
|
N
|
P
|
F
|
I
|
Y
|
A
|
Y
|
| 290 | |||||||||
| H8 | |||||||||
|
R
|
I
|
R
|
E
|
F
|
R
|
Q
|
T
|
F
|
R
|
| 300 | |||||||||
|
K
|
I
|
I
|
R
|
S
|
H
|
V
|
L
|
R
|
Q
|
| 310 | |||||||||
| C-term | |||||||||
|
Q
|
E
|
P
|
F
|
K
|
A
|
A
|
G
|
T
|
S
|
| 320 | |||||||||
|
A
|
R
|
V
|
L
|
A
|
A
|
H
|
G
|
S
|
D
|
| 330 | |||||||||
|
G
|
E
|
Q
|
V
|
S
|
L
|
R
|
L
|
N
|
G
|
| 340 | |||||||||
|
H
|
P
|
P
|
G
|
V
|
W
|
A
|
N
|
G
|
S
|
| 350 | |||||||||
|
A
|
P
|
H
|
P
|
E
|
R
|
R
|
P
|
N
|
G
|
| 360 | |||||||||
|
Y
|
A
|
L
|
G
|
L
|
V
|
S
|
G
|
G
|
S
|
| 370 | |||||||||
|
A
|
Q
|
E
|
S
|
Q
|
G
|
N
|
T
|
G
|
L
|
| 380 | |||||||||
|
P
|
D
|
V
|
E
|
L
|
L
|
S
|
H
|
E
|
L
|
| 390 | |||||||||
|
K
|
G
|
V
|
C
|
P
|
E
|
P
|
P
|
G
|
L
|
| 400 | |||||||||
|
D
|
D
|
P
|
L
|
A
|
Q
|
D
|
G
|
A
|
G
|
| 410 | |||||||||
|
V
|
S
|
DIAGRAMS
7TM
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
, 'snake_aa2ar_human.png',
{scale: 3});){kind=link}
, 'snake_aa2ar_human.jpg',
{scale: 3});){kind=link}
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
, 'helixbox_aa2ar_human.png',
{scale: 3});){kind=link}
, 'helixbox_aa2ar_human.jpg',
{scale: 3});){kind=link}
MUTATIONS
PHYSIOLOGICAL LIGANDS
adenosine
STRUCTURE MODELS
STRUCTURES
Found 188 structure(s) - view all details on the Structures page
PDBs: 9XQB, 9EE9, 9P1S, 6GDG, 9P1T, 9T9P, 7T32, 9EE8, 9EEA, 7RM5, 8FYN, 7PX4, 8CU7, 7INR, 8A2P, 8RW4, 5OLG, 3UZC, 7IP3, 7IPB, 7IO1, 7IN1, 7IOU, 6LPL, 6S0Q, 7IPG, 7IN5, 4EIY, 5K2C, 5NLX, 5IU8, 5K2B, 5MZJ, 5OLV, 5IU4, 5NM2, 5IUA, 5IUB, 4UG2, 3EML, 10KT, 8RWI, 5OLZ, 4UHR, 3RFM, 3QAK, 5K2D, 5JTB, 2YDO, 5OLO, 5G53, 5IU7, 5N2R, 3UZA, 7EZC, 3PWH, 3VGA, 3VG9, 7ION, 7IOF, 7IPF, 7IOR, 7INC, 3REY, 5OM4, 5UVI, 5K2A, 6GT3, 8JWZ, 5WF5, 5WF6, 5VRA, 8WDT, 8RW0, 8RWH, 8RWE, 7IOY, 8RVW, 8UGW, 8RWD, 8RWX, 8RLN, 8RW7, 8RWC, 6LPJ, 6PS7, 6WQA, 6ZDV, 7ARO, 6MH8, 9H2X, 9FUP, 7IN2, 7IP1, 7IP4, 7INB, 7INN, 7INI, 7IO7, 7INT, 7IND, 7INE, 7ING, 7INW, 7IN7, 7IO8, 7INM, 7INV, 7INP, 7INK, 7IN8, 7INQ, 7IO2, 7INX, 7IOA, 7INY, 7IO9, 7IO4, 7IOB, 7IO3, 7IN9, 7INJ, 7INO, 7IN3, 7IP2, 7INL, 7IPA, 7IOS, 7IOL, 7IO5, 7IOE, 7IP8, 7IOQ, 7IOO, 7IOK, 7IOV, 7IPC, 7IOM, 7IOJ, 7IOC, 7IPE, 7IOD, 7IP0, 7IOG, 7IOH, 7IPD, 7IOP, 7IP5, 7IOZ, 7IP9, 7INH, 7IO0, 7INZ, 7IP6, 7IOW, 7IP7, 6ZDR, 7PYR, 8C9W, 8DU3, 8A2O, 8CU6, 8GNE, 8GNG, 7INU, 7INA, 7IOT, 7IOX, 7IOI, 7INF, 7IO6, 6LPK, 6JZH, 5UIG, 8JWY, 8RQQ, 8CIC, 2YDV, 5NM4, 5OM1, 5OLH, 7IN4, 9H37, 8PWN, 7IN6, 6S0L, 5MZP, 6AQF