CCR3 (ccr3_human)

FAMILY

Class A (Rhodopsin) Protein receptors Chemokine receptors CCR3

GENE

CCR3

ORGANISM

Human (Homo sapiens)

ALT. NAMES

C-C chemokine receptor type 3, C C CKR3, C-C CKR-3, CC-CKR-3, CCR-3, CCR3, CKR 3, CKR3, Eosinophil eotaxin receptor, CD193

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
T
T
S
L
D
T
V
E
T
10
                   
F
G
T
T
S
Y
Y
D
D
V
20
          TM1    
G
L
L
C
E
K
A
D
T
R
30
                   
A
L
M
A
Q
F
V
P
P
L
40
                   
Y
S
L
V
F
T
V
G
L
L
50
                   
G
N
V
V
V
V
M
I
L
I
60
    ICL1 TM2  
K
Y
R
R
L
R
I
M
T
N
70
                   
I
Y
L
L
N
L
A
I
S
D
80
                   
L
L
F
L
V
T
L
P
F
W
90
                   
I
H
Y
V
R
G
H
N
W
V
100
ECL1 TM3      
F
G
H
G
M
C
K
L
L
S
110
                   
G
F
Y
H
T
G
L
Y
S
E
120
                   
I
F
F
I
I
L
L
T
I
D
130
                   
R
Y
L
A
I
V
H
A
V
F
140
ICL2   TM4    
A
L
R
A
R
T
V
T
F
G
150
                   
V
I
T
S
I
V
T
W
G
L
160
                   
A
V
L
A
A
L
P
E
F
I
170
    ECL2        
F
Y
E
T
E
E
L
F
E
E
180
                   
T
L
C
S
A
L
Y
P
E
D
190
TM5              
T
V
Y
S
W
R
H
F
H
T
200
                   
L
R
M
T
I
F
C
L
V
L
210
                   
P
L
L
V
M
A
I
C
Y
T
220
                   
G
I
I
K
T
L
L
R
C
P
230
ICL3 TM6      
S
K
K
K
Y
K
A
I
R
L
240
                   
I
F
V
I
M
A
V
F
F
I
250
                   
F
W
T
P
Y
N
V
A
I
L
260
                   
L
S
S
Y
Q
S
I
L
F
G
270
ECL3 TM7      
N
D
C
E
R
S
K
H
L
D
280
                   
L
V
M
L
V
T
E
V
I
A
290
                   
Y
S
H
C
C
M
N
P
V
I
300
        H8        
Y
A
F
V
G
E
R
F
R
K
310
                   
Y
L
R
H
F
F
H
R
H
L
320
C-term        
L
M
H
L
G
R
Y
I
P
F
330
                   
L
P
S
E
K
L
E
R
T
S
340
                   
S
V
S
P
S
T
A
E
P
E
350
         
L
S
I
V
F

LINKS

ChEMBL

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 R R L R ICL1ECL1 N W V F ECL1ICL2 A V F A L R A R ICL2ECL2 E T E E L F E E T L C S A L Y P E D ECL2ICL3 P S ICL3ECL3 G N ECL3N-term M T T S L D T V E T F G T T S Y Y D D V G L L C E N-termC-term H L L M H L G R Y I P F L P S E K L E R T S S V S P S T A E P E L S I V F C-term K A D T R A L M A Q F V P P L Y S L V F T V G L L G N V V V V M I L I K Y I M T N I Y L L N L A I S D L L F L V T L P F W I H Y V R G H G H G M C K L L S G F Y H T G L Y S E I F F I I L L T I D R Y L A I V H T V T F G V I T S I V T W G L A V L A A L P E F I F Y T V Y S W R H F H T L R M T I F C L V L P L L V M A I C Y T G I I K T L L R C K K K Y K A I R L I F V I M A V F F I F W T P Y N V A I L L S S Y Q S I L F D C E R S K H L D L V M L V T E V I A Y S H C C M N P V I Y A F V G E R L R H F R K Y F F H R
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

V N G L L G V T F V L S Y L P P V F Q A 1 L N L A I S D L L F L V T L P F W I H Y 2 L I I F F I E S Y L G T H Y F G S L L K 3 G V I T S I V T W G L A V L A A L P E 4 Y C I A M V L L P L V L C F I T M R L T H 5 F V I M A V F F I F W T P Y N V A I L L 6 V P N M C C H S Y A I V E T V L M V L 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

26 mutation data points available.

PHYSIOLOGICAL LIGANDS

CCL24 (Mouse), CXCL10 (Mouse), CCL7 (Human), CXCL10 (Rat), CXCL11 (Mouse), CCL13 (Human), CCL11 (Rat), CCL11 (Mouse), CCL8 (Human), CXCL10 (Human), CCL2 (Rat), CCL5 (Mouse), CCL5 (Human), CCL28 (Mouse), CXCL9 (Human), CCL24 (Human), CXCL9 (Mouse), CCL7 (Rat), CCL11 (Human), CCL28 (Human), CCL2 (Human), CCL26 (Human), CCL8 (Mouse), CCL7 (Mouse), CCL2 (Mouse), CXCL11 (Human), CCL15 (Human)

STRUCTURE MODELS

ccr3_human inactive,

ccr3_human active

STRUCTURES

Found 1 structure(s) - view all details on the Structures page

PDBs: 7X9Y